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https://www.readbyqxmd.com/read/28726497/prognosis-prediction-for-postoperative-esophageal-cancer-patients-using-onodera-s-prognostic-nutritional-index
#1
Hideo Matsumoto, Yuko Okamoto, Akimasa Kawai, Daisuke Ueno, Hisako Kubota, Haruaki Murakami, Masaharu Higashida, Toshihiro Hirai
PURPOSE: Preoperative nutritional status may impact surgical outcome and prognosis. We evaluated the predictive value of Onodera's prognostic nutritional index (O's-PNI) of surgical outcome following esophagectomy in esophageal cancer patients. PATIENTS AND METHODS: In total, 144 patients undergoing esophagectomy for esophageal cancer from April 2010 to May 2015 were evaluated, retrospectively. Eighty-four patients were enrolled in this study. O's-PNIs were calculated before surgery, discharge, and 1, 2, and 6 mo after discharge...
July 20, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28707326/perineural-invasion-present-exclusively-in-central-tissue-blocks-of-mohs-surgical-excisions-of-basal-cell-carcinoma
#2
Lauren Young, Dougal Coates, John Pagliaro, David Francis, Richard Williamson, Zoran Gaspar
Perineural invasion (PNI) may be present in basal cell carcinomas (BCC) treated with Mohs micrographic surgery. This single-centre, non-randomised, prospective study demonstrates the potential for PNI to exist exclusively within the central tissue blocks of Mohs specimens.
July 14, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28706446/derived-neutrophil-to-lymphocyte-ratio-and-monocyte-to-lymphocyte-ratio-may-be-better-biomarkers-for-predicting-overall-survival-of-patients-with-advanced-gastric-cancer
#3
Shubin Song, Chunfeng Li, Sen Li, Hongyu Gao, Xiuwen Lan, Yingwei Xue
BACKGROUND AND OBJECTIVES: Preoperative systemic inflammatory response and nutritional status play important roles in the tumorigenesis, progression, and prognosis of gastric cancer (GC). This research is designed to investigate the prognostic value of the biomarkers including the neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI) in predicting overall survival in patients with GC...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28705708/perineural-invasion-by-prostate-cancer-on-mr-us-fusion-targeted-biopsy-is-associated-with-extraprostatic-extension-and-early-biochemical-recurrence-after-radical-prostatectomy
#4
Matthew Truong, Soroush Rais-Bahrami, Jeffrey W Nix, Edward M Messing, Hiroshi Miyamoto, Jennifer B Gordetsky
In recent years, multiparametric magnetic resonance imaging (MRI) and MR/ultrasound (US) fusion targeted biopsy (TB) have become more widely adopted to aid in prostate cancer (PCa) detection. Previously, TB has been found to increase the yield of clinically significant PCa and is more likely to sample the index tumor compared to traditional 12-core extended sextant biopsies. Currently the prognostic significance of perineural invasion (PNI) when identified on TB (PNI-TB) is unknown. We identified 95 men at two tertiary referral centers who underwent TB followed by radical prostatectomy between January 2014 and January 2017...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28698895/using-anatomical-landmark-to-avoid-phrenic-nerve-injury-during-balloon-based-procedures-in-atrial-fibrillation-patients
#5
Nicolina M Smith, Larry Segars, Travis Kauffman, Anthony B Olinger
PURPOSE: Atrial fibrillation (AF) is an arrhythmia which affects as many as 2.7 million Americans. AF should be treated, because it can lead to a four-to-fivefold increased risk of experiencing a stroke. The American College of Cardiology/American Heart Association guidelines for the treatment of drug refractory and symptomatic paroxysmal AF denote catheter ablation as the standard of care. The newest ablation treatment, cryoballoon, uses a cold balloon tip. The biggest risk factor associated with the cryoballoon ablation is phrenic nerve injury (PNI)...
July 11, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28692526/preoperative-nutritional-assessment-with-the-prognostic-nutrition-index-in-patients-undergoing-left-ventricular-assist-device-implantation
#6
Gardner Yost, Antone Tatooles, Geetha Bhat
The prognostic nutritional index (PNI) is a simple metric that uses serum albumin and total lymphocyte count to provide a basic indicator for nutritional status. It has recently garnered attention as a prognosticator of outcomes in many types of cancer. We investigated the utility of the PNI as a marker for poor outcomes following left ventricular assist device (LVAD) implantation. Two hundred eighty-eight consecutive patients implanted with continuous-flow LVADs were included. Prognostic nutritional index was calculated for all patients (PNI = [10 × serum albumin {g/dl}] + [0...
July 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28688913/neuroprotective-effect-of-lovastatin-on-motor-deficit-induced-by-sciatic-nerve-crush-in-the-rat
#7
Mohammad B Ghayour, Arash Abdolmaleki, Morteza B Rassouli
Following severe peripheral nerve injury (PNI), regeneration is often insufficient and functional recovery is incomplete. Any agents that limit the spread of neural tissue damage may enhance the nerve regeneration. In this regard, statins have been shown to have neuroprotective properties. We investigated the effects of Lovastatin against sciatic nerve crush injury in male Wistar Rats. Lovastatin or vehicle was given parenteraly to rats for 7 days postoperative. In Lovastatin treatment groups, a single dose of agent (2 and 5mg/kg) was administered daily...
July 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28681422/prognostic-indicators-and-survival-in-salvage-surgery-for-laryngeal-cancer
#8
Kyle T Fletcher, Thomas J Gal, Andrew J Ebelhar, Joseph Valentino, Yolanda M Brill, Emily V Dressler, Rony K Aouad
BACKGROUND: Perineural invasion (PNI) and lymphovascular invasion (LVI) are known to be poor prognostic indicators in primary surgery. The purpose of this study was to determine their impact on survival in the setting of salvage laryngectomy. METHODS: We conducted a retrospective review of patients who underwent salvage laryngectomy between 2006 and 2014. RESULTS: Seventy-eight patients were included in this study; PNI was diagnosed in 48 patients (61...
July 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28678985/clinical-and-incidental-perineural-invasion-of-cutaneous-squamous-cell-carcinoma-a-systematic-review-and-pooled-analysis-of-outcomes-data
#9
Pritesh S Karia, Frederick C Morgan, Emily Stamell Ruiz, Chrysalyne D Schmults
Importance: Perineural invasion (PNI) in cutaneous squamous cell carcinoma (CSCC) has been associated with an increased risk of poor outcomes. Patients with PNI may present with clinical symptoms and/or radiologic evidence of PNI (clinical PNI [CPNI]), yet most patients are asymptomatic and PNI is often found on histologic examination (incidental PNI [IPNI]). Evidence-based estimates of the risks of disease-related outcomes comparing IPNI and CPNI are limited in the dermatology literature...
July 5, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28668901/perineural-invasion-is-a-prognostic-factor-and-treatment-indicator-in-patients-with-rectal-cancer-undergoing-curative-surgery-2000-2011-data-from-a-single-center-study
#10
Tetsushi Kinugasa, Tomoaki Mizobe, Sachiko Shiraiwa, Yoshito Akagi, Kazuo Shirouzu
BACKGROUND/AIM: The aim of the present study was to investigate whether perineural invasion (PNI) was a prognostic index for patients who underwent curative surgery for Dukes' grade B and C rectal cancer. PATIENTS AND METHODS: A total of 645 patients with rectal cancer between January 2000 and December 2011; 363 with Dukes' B or C stages who did not undergo chemoradiotherapy were reviewed. RESULTS: Of 363 patients, 83 (22.9%) were PNI-positive...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28668874/immunological-status-may-predict-response-to-nivolumab-in-non-small-cell-lung-cancer-without-driver-mutations
#11
Makoto Nakao, Hideki Muramatsu, Yusuke Kagawa, Yuto Suzuki, Yusuke Sakai, Ryota Kurokawa, Kohei Fujita, Hidefumi Sato
BACKGROUND/AIM: It remains challenging to select patients with non-small cell carcinoma (NSCLC) for nivolumab monotherapy. We evaluated whether early termination of nivolumab monotherapy correlated with pretreatment neutrophil/lymphocyte ratio (NLR) and prognostic nutritional index (PNI). PATIENTS AND METHODS: Twenty patients received nivolumab monotherapy for NSCLC with wild-type epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) during 2016...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28667930/transected-sciatic-nerve-repair-by-diode-laser-protein-soldering
#12
Reza Fekrazad, Omid Mortezai, MirSepehr Pedram, Katayoun Am Kalhori, Khojasteh Joharchi, Korosh Mansoori, Roja Ebrahimi, Fatemeh Mashhadiabbas
BACKGROUND AND OBJECTIVE: Despite advances in microsurgical techniques, repair of peripheral nerve injuries (PNI) is still a major challenge in regenerative medicine. The standard treatment for PNI includes suturing and anasthomosis of the transected nerve. The objective of this study was to compare neurorraphy (nerve repair) using standard suturingto diode laser protein soldering on the functional recovery of transected sciatic nerves. STUDY DESIGN/MATERIALS AND METHODS: Thirty adult male Fischer-344 Wistar rats were randomly assigned to 3 groups: 1...
June 13, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28656348/pap-reg3a-favors-perineural-invasion-in-pancreatic-adenocarcinoma-and-serves-as-a-prognostic-marker
#13
Jérémy Nigri, Meritxell Gironella, Christian Bressy, Elena Vila-Navarro, Julie Roques, Sophie Lac, Caroline Bontemps, Coraline Kozaczyk, Jérôme Cros, Daniel Pietrasz, Raphaël Maréchal, Jean-Luc Van Laethem, Juan Iovanna, Jean-Baptiste Bachet, Emma Folch-Puy, Richard Tomasini
Pancreatic ductal adenocarcinoma (PDA) is a fatal and insidious malignant disease for which clinicians' tools are restricted by the current limits in knowledge of how tumor and stromal cells act during the disease. Among PDA hallmarks, neural remodeling (NR) and perineural invasion (PNI) drastically influence quality of life and patient survival. Indeed, NR and PNI are associated with neuropathic pain and metastasis, respectively, both of which impact clinicians' decisions and therapeutic options. The aim of this study was to determine the impact and clinical relevance of the peritumoral microenvironment, through pancreatitis-associated protein (PAP/REG3A) expression, on PNI in pancreatic cancer...
June 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28649089/prognostic-nutritional-index-and-the-risk-of-mortality-in-patients-with-acute-heart-failure
#14
Yu-Lun Cheng, Shih-Hsien Sung, Hao-Min Cheng, Pai-Feng Hsu, Chao-Yu Guo, Wen-Chung Yu, Chen-Huan Chen
BACKGROUND: Nutritional status has been related to clinical outcomes in patients with heart failure. We assessed the association between nutritional status, indexed by prognostic nutritional index (PNI), and survival in patients hospitalized for acute heart failure. METHODS AND RESULTS: A total of 1673 patients (age 76±13 years, 68% men) hospitalized for acute heart failure in a tertiary medical center were analyzed. PNI was calculated as 10×serum albumin (g/dL)+0...
June 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28647740/integrative-assessment-of-pretreatment-inflammation-nutrition-and-muscle-based-prognostic-markers-in-patients-with-muscle-invasive-bladder-cancer-undergoing-radical-cystectomy
#15
Makito Miyake, Yosuke Morizawa, Shunta Hori, Nagaaki Marugami, Kota Iida, Kenta Ohnishi, Daisuke Gotoh, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Keiji Shimada, Noboru Konishi, Kiyohide Fujimoto
OBJECTIVE: The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS: The analysis enrolled 117 patients and the variables included age, body mass index (BMI), neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, modified Glasgow Prognostic Score (mGPS), prognostic nutritional index (PNI), Controlling Nutritional Status score, psoas muscle index (PMI), and peak expiratory flow (PEF)...
June 24, 2017: Oncology
https://www.readbyqxmd.com/read/28644887/sarcopenia-is-a-predictive-factor-for-intestinal-resection-in-admitted-patients-with-crohn-s-disease
#16
Shigeki Bamba, Masaya Sasaki, Azusa Takaoka, Kenichiro Takahashi, Hirotsugu Imaeda, Atsushi Nishida, Osamu Inatomi, Mitsushige Sugimoto, Akira Andoh
The relationship between skeletal muscle volume and the prognosis of patients with inflammatory bowel disease (IBD) remains undetermined. We conducted a retrospective study of 72 IBD patients who were admitted to the hospital due to disease exacerbation. We enrolled IBD patients who had undergone abdominal computed tomography and assessed the nutritional indices, such as the Onodera's prognostic nutritional index (O-PNI) and the controlling nutritional status (CONUT) index. The L3 skeletal muscle index (SMI), which is the ratio of the cross-sectional area of skeletal muscles at the level of the third lumbar (L3) vertebra to the height squared, was used to identify sarcopenia...
2017: PloS One
https://www.readbyqxmd.com/read/28638231/pleiotrophin-and-n-syndecan-promote-perineural-invasion-and-tumor-progression-in-an-orthotopic-mouse-model-of-pancreatic-cancer
#17
Jun Yao, Lu-Lin Zhang, Xu-Mei Huang, Wen-Yao Li, She-Gan Gao
AIM: To detect the expression of pleiotrophin (PTN) and N-syndecan in pancreatic cancer and analyze their association with tumor progression and perineural invasion (PNI). METHODS: An orthotopic mouse model of pancreatic cancer was created by injecting tumor cells subcapsularly in a root region of the pancreas beneath the spleen. Pancreatic cancer tissues were taken from 36 mice that survived for more than 90 d. PTN and N-syndecan proteins were detected by immunohistochemistry and analyzed for their correlation with pathological features, PNI, and prognosis...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28615804/the-neurochemistry-of-peripheral-nerve-regeneration
#18
Andreea Benga, Fatih Zor, Ahmet Korkmaz, Bogdan Marinescu, Vijay Gorantla
Peripheral nerve injuries (PNIs) can be most disabling, resulting in the loss of sensitivity, motor function and autonomic control in the involved anatomical segment. Although injured peripheral nerves are capable of regeneration, sub-optimal recovery of function is seen even with the best reconstruction. Distal axonal degeneration is an unavoidable consequence of PNI. There are currently few strategies aimed to maintain the distal pathway and/or target fidelity during regeneration across the zone of injury...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28615532/extranodal-extension-status-is-a-powerful-prognostic-factor-in-stage-iii-colorectal-cancer
#19
Chan Wook Kim, Jihun Kim, Seung-Seop Yeom, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Seunghee Baek, Chang Sik Yu, Jin Cheon Kim
PURPOSE: The present study aimed to evaluate the clinicopathologic characteristics of patients with extranodal extension (ENE) and the prognostic implications of ENE in stage III colorectal cancer (CRC). RESULTS: ENE was more frequent in younger patients and those with rectal cancer, higher T stage, higher N stage, lymphovascular invasion (LVI), and perineural invasion (PNI). Five-year disease-free survival (DFS) and overall survival (OS) were lower in patients with ENE-positive than in those with ENE-negative tumors (DFS, 66...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615514/prognostic-value-of-the-c-reactive-protein-prognostic-nutritional-index-ratio-after-hip-fracture-surgery-in-the-elderly-population
#20
Hanru Ren, Lianghao Wu, Wankun Hu, Xiuzhang Ye, Baoqing Yu
BACKGROUND: More and more older patients receive the surgery after hip fracture. However, the mortality rate is high. Prognostic nutritional index (PNI) is associated with prognosis in hip fracture patients. In the current study, we proposed a novel prognostic score, named c-reactive protein/PNI ratio (CRP/PNI ratio), for predicting the prognosis for geriatric orthopedic population. METHODS: This is a prospective study. Eighty cases of hip fracture surgery in the elderly population were studied to reveal the relationship between the CRP/PNI ratio and the clinicopathological characteristics of the elderly patients...
May 24, 2017: Oncotarget
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