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https://www.readbyqxmd.com/read/28940496/left-phrenic-nerve-injury-during-electrical-isolation-of-left-sided-pulmonary-veins-with-the-second-generation-cryoballoon
#1
Kaoru Okishige, Hideshi Aoyagi, Takurou Nishimura, Takatoshi Shigeta, Takehiko Keida, Yasuteru Yamauchi, Tetsuo Sasano, Kenzo Hirao
BACKGROUND: Phrenic nerve (PN) palsy (PNP) is the most frequent complication of cryoballoon ablation (CBA) of atrial fibrillation (AF). The major complication of this technique seems to be right-sided PN injury (PNI) following ablation of the right pulmonary veins (PVs). We sought to assess the incidence and prognosis of left-sided PNI during CBA. METHODS: CBA was performed in 448 patients with AF. During the ablation of the left-sided PVs, the PN was paced from the left subclavian vein with a pacing output just exceeding the threshold by 10∼20%...
September 21, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28902234/monitoring-of-post-vaccination-anti-hbs-titles-vaccine-in-children-and-adolescents-in-the-pre-dialysis-of-chronic-kidney-disease
#2
Nathália Cristina Pereira da Costa, Mônica Ribeiro Canhestro, Cristina Maria Bouissou Morais Soares, Juliana Scudilio Rodrigues
Introduction: Bacterial or viral diseases are one of the major causes of death in patients with chronic kidney disease (CKD). These patients show a quantitative reduction of levels of antibodies over time. Among the infectious diseases that affect CKD patients, stands out hepatitis B (HB). Immunization and control of antibodies levels against the hepatitis B surface antigen (anti-HBs) are ways to prevent the HB infection in this population. Patients with anti-HBs levels ≥10 IU/ml are considered adequate responders, whereas those with anti-HBs levels ≥ 100 IU/ml are considered excellent responders...
August 28, 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28889323/significance-of-preoperative-prognostic-nutrition-index-as-prognostic-predictors-in-patients-with-metastatic-renal-cell-carcinoma-with-tyrosine-kinase-inhibitors-as-first-line-target-therapy
#3
Wen Cai, Hai Zhong, Wen Kong, Baijun Dong, Yonghui Chen, Lixin Zhou, Wei Xue, Yiran Huang, Jin Zhang, Jiwei Huang
OBJECTIVE: Prognostic nutritional index (PNI) is a recognized indicator of both immune and nutritional status. It was firstly used as a preoperative prognostic indicator, and its role in the prognosis of patients with metastatic renal cell carcinoma (mRCC) has not yet been investigated in large-scale study. The purpose of this work was to investigate the prognostic role of pretreatment PNI in patients with mRCC with sorafenib or sunitinib as first-line targeted therapy. METHOD: In this retrospective single-center research, the Kaplan-Meier method was used to estimate the progression-free survival (PFS) and overall survival (OS) of 178 mRCC patients who received first-line therapy of sorafenib or sunitinib...
September 9, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28886432/traumatic-lower-extremity-and-lumbosacral-peripheral-nerve-injuries-in-adults-electrodiagnostic-studies-and-patients-symptoms
#4
Arash Babaei-Ghazani, Bina Eftekharsadat, Bahram Samadirad, Vida Mamaghany, Saeed Abdollahian
BACKGROUND: Peripheral nerve injuries (PNI) are relatively common pathologies in clinical practice. PNIs are rare in the lower extremity but have worse prognosis than those in the upper extremity. Electrodiagnostic studies could help better understanding PNIs. In this study, we aimed to evaluate the distribution of lower extremity PNI in traumatic patients in northwest of Iran. METHODS: In this prospective study, 74 patients (62 male and 12 female with mean age of 38...
August 24, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28876670/foley-catheter-balloon-tamponade-fcbt-for-penetrating-neck-injuries-pni-at-groote-schuur-hospital-an-update
#5
M F Scriba, P H Navsaria, A J Nicol, S Edu, A Al-Sayari
BACKGROUND: A previous study from Groote Schuur Hospital (GSH) highlighted the success of FCBT (PNI). METHOD: The records of all patients with PNI requiring FCBT for a neck injury presenting to GSH within an 11-month study period were reviewed. Prospectively captured data on the Electronic Trauma Health Record Application (eTHRApp), was retrospectively analysed. Analysed data included demographics, clinical signs on admission, imaging, management and major outcomes...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28871777/developing-an-inositol-phosphate-actuated-nanochannel-system-by-mimicking-biological-calcium-ion-channels
#6
Qi Lu, Qiuhan Tang, Zhonghui Chen, Shilong Zhao, Guangyan Qing, Taolei Sun
In eukaryotic cells, ion channels, which ubiquitously present as polypeptides or proteins, usually regulate the ion transport across biological membranes by conformational switching of the channel proteins in response to the binding of diverse signaling molecules (e.g., inositol phosphate, abbreviated to InsP). To mimic the gating behaviors of natural Ca(2+) channels manipulated by InsPs, a smart poly[(N-isopropylacrylamide-co-4-(3-acryloylthioureido) benzoic acid)0.2] (denoted as PNI-co-ATBA0.2) was integrated onto a porous anodic alumina (PAA) membrane, building an InsP-actuated nanochannel system...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28852045/analysis-of-temporal-expression-profiles-after-sciatic-nerve-injury-by-bioinformatic-method
#7
Yichong Zhang, Yuanbo Zhan, Na Han, Yuhui Kou, Xiaofeng Yin, Peixun Zhang
After Peripheral nerve injuries (PNI), many complicated pathophysiologic processes will happen. A global view of functional changes following PNI is essential for the looking for the adequate therapeutic approaches. In this study, we performed an in-depth analysis on the temporal expression profiles after sciatic nerve injury by bioinformatic methods, including (1) cluster analysis of the samples; (2) identification of gene co-expression modules(CEMs) correlated with the time points; (3) analysis of differentially expressed genes at each time point (DEGs-ET); (4) analysis of differentially expressed genes varying over time (DEGs-OT); (5) creating Pairwise Correlation Plot for the samples; (6) Time Series Regression Analysis; (7) Determining the pathway, GO (gene ontology) and drug by enrichment analysis...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842710/preoperative-prognostic-nutritional-index-is-a-powerful-predictor-of-prognosis-in-patients-with-stage-iii-ovarian-cancer
#8
Weiwei Zhang, Bin Ye, Weijiang Liang, Yazhou Ren
Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutritional index (PNI). This study was performed to estimate the prognostic value of these factors in predicting survival and platinum resistance in ovarian cancer (OC), especially according to stage...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840521/utility-of-serum-inflammatory-markers-for-predicting-microvascular-invasion-and-survival-for-patients-with-hepatocellular-carcinoma
#9
Jian Zheng, Ken Seier, Mithat Gonen, Vinod P Balachandran, T Peter Kingham, Michael I D'Angelica, Peter J Allen, William R Jarnagin, Ronald P DeMatteo
BACKGROUND: Preoperative serum inflammatory markers have been correlated with outcome after resection of hepatocellular carcinoma (HCC), but studies have had conflicting results. This study aimed to evaluate the association of six inflammatory markers with recurrence-free survival (RFS), overall survival (OS), and microvascular invasion (MVI), a well-known prognostic factor. METHODS: This study investigated 370 patients who underwent resection of HCC from 1992 to 2016, retrospectively evaluating their inflammatory indices and individual components including their neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), aspartate aminotransferase-to-platelet ratio index (APRI), and aspartate aminotransferase-to-neutrophil ratio index (ANRI)...
August 24, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28836056/the-prognostic-significance-of-inflammation-based-markers-in-patients-with-recurrent-gastric-cancer
#10
Kazuhiro Migita, Sohei Matsumoto, Kohei Wakatsuki, Masahiro Ito, Tomohiro Kunishige, Hiroshi Nakade, Mutsuko Kitano, Mitsuhiro Nakatani, Masayuki Sho
PURPOSE: The aim of this study was to evaluate the prognostic impact of inflammation-based markers, including the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI), in patients with recurrent gastric cancer (RGC). METHODS: This study reviewed 167 patients with RGC. A receiver operating characteristics (ROC) curve analysis was performed to determine the NLR and PNI cutoff values. The prognostic significance of the NLR and PNI was evaluated by a multivariate analysis...
August 23, 2017: Surgery Today
https://www.readbyqxmd.com/read/28826702/preoperative-prognostic-nutritional-index-is-a-significant-predictor-of-survival-in-patients-with-localized-upper-tract-urothelial-carcinoma-after-radical-nephroureterectomy
#11
Jiwei Huang, Yichu Yuan, Yanqing Wang, YongHui Chen, Wen Kong, Wei Xue, Haige Chen, Jin Zhang, Yiran Huang
BACKGROUND: Patient's nutritional and immunological status have a potentially significant role in survival outcome in patients with malignant tumors. We investigated the prognostic value of preoperative prognostic nutritional index (PNI) in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephrouretectomy (RNU). PATIENTS AND METHODS: A total of 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent RNU were evaluated. PNI was calculated as 10 × serum albumin concentration (g/dl) + 0...
August 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28822786/leptin-is-essential-for-microglial-activation-and-neuropathic-pain-after-preganglionic-cervical-root-avulsion
#12
Kai-Ting Chang, Yi-Lo Lin, Chi-Te Lin, Chen-Jei Hong, May-Jywan Tsai, Wen-Cheng Huang, Yang-Hsin Shih, Yi-Yen Lee, Henrich Cheng, Ming-Chao Huang
AIMS: Preganglionic cervical root avulsion (PCRA) affects both the peripheral and central nervous systems and is often associated with neuropathic pain. Unlike peripheral nerve injuries (PNI), central lesions caused by disruption of cervical roots from the spinal cord following PCRA contribute to the generation of neuropathic pain. Leptin is involved in the development of neuropathic pain after PNI by affecting neurons. However, whether leptin is involved in microglial activation leading to neuropathic pain after PCRA is unknown...
October 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28813963/novel-neural-interface-electrode-array-for-the-peripheral-nerve
#13
Ockchul Kim, Wonsuk Choi, Woohyun Jung, Sunyoung Jung, HyungDal Park, Jong Woong Park, Jinseok Kim
Peripheral neural interface (PNI) is becoming an essential technology in the field of robotic prosthesis due to its potential for providing bidirectional neural signal communication between the prosthetic arm and the brain. However, current PNIs inefficiently trade off neural signal selectivity and the invasiveness of the device. We designed and fabricated a new PNI electrode array that has high signal selectivity yet maintains low invasiveness by incorporating a design that allows for three-dimensional spiral insertion around the peripheral nerve...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28808503/prognostic-efficacy-of-inflammation-based-markers-in-patients-with-curative-colorectal-cancer-resection
#14
Özgür Akgül, Erdinç Çetinkaya, Metin Yalaza, Sabri Özden, Mesut Tez
AIM: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and prognostic nutritional index (PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer. METHODS: 183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels (CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival (months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database...
July 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28803356/the-prognostic-impact-of-malnutrition-in-patients-with-severely-decompensated-acute-heart-failure-as-assessed-using-the-prognostic-nutritional-index-pni-and-controlling-nutritional-status-conut-score
#15
Akihiro Shirakabe, Noritake Hata, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Suguru Nishigoori, Saori Uchiyama, Kuniya Asai, Wataru Shimizu
Patients with heart failure (HF) are sometimes classified as malnourished, but the prognostic value of nutritional status in acute HF (AHF) remains largely unstudied. 1214 patients who were admitted to the intensive care unit between January 2000 and June 2016 were screened based on their serum albumin, lymphocyte count, and total cholesterol measures. A total of 458 HF patients were enrolled in this study. The Prognostic Nutritional Index (PNI) is calculated as 10 × serum albumin (g/dL) + 0.005 × lymphocyte count (per mm(3)) (lower = worse)...
August 12, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28801062/perineural-invasion-through-the-sheath-in-posttherapy-esophagectomy-specimens-predicts-poor-survival-in-patients-with-esophageal-squamous-cell-carcinoma
#16
C-Y Tsai, C-J Yeh, Y-K Chao, H-K Chang, C-K Tseng, Y-H Liu
BACKGROUND: The prognostic impact of perineural invasion (PNI) in patients with esophageal cancer who receive neoadjuvant chemoradiotherapy (nCRT) remains unclear. METHODS: A thorough pathological review of PNI was performed on post-nCRT esophagectomy specimens obtained from non-ypT0 patients with esophageal squamous cell carcinoma (ESCC). When PNI was identified, it was classified according to the presence or absence of penetration through the nerve sheath (i.e...
August 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28790844/plasma-fibrinogen-and-serum-albumin-levels-fa-score-act-as-a-promising-prognostic-indicator-in-non-small-cell-lung-cancer
#17
Pengxiang Chen, Cong Wang, Bo Cheng, Effat Un Nesa, Yuan Liu, Yibin Jia, Yan Qu, Ziying Jiang, Jie Han, Yufeng Cheng
BACKGROUND: Evidence implies that preoperative plasma fibrinogen and serum albumin are associated with cancer prognosis. We aimed to explore the prognostic values of the score based on plasma fibrinogen and serum albumin levels (FA score) in non-small cell lung cancer (NSCLC), and to compare that with prognostic nutritional index (PNI). PATIENTS AND METHODS: In all, 182 patients pathologically diagnosed with NSCLC were included in this study. Kaplan-Meier survival analysis and multivariate analysis were used in the prognostic analyses...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28781800/clinicopathological-and-prognostic-characteristics-in-patients-with-afp-secreting-gastric-carcinoma
#18
Yakup Bozkaya, Nebi Serkan Demirci, Alican Kurtipek, Gökmen Umut Erdem, Nuriye Yildirim Ozdemir, Nurullah Zengin
The aim of the present study was to determine whether there are any clinicopathological or prognostic differences between patients with α-fetoprotein-secreting gastric carcinoma (AFP-SGC) and non-AFP-SGC. Pathological parameters, clinical parameters, and treatment efficacy were compared in patients with AFP-SGC and non-AFP-SGC. In total, 362 patients (53 with AFP-SGC and 309 with non-AFP-SGC) were included in the present study. Patients with AFP-SGC had significantly higher levels of lymphovascular invasion, perineural invasion (PNI), rate of liver metastasis, and stage IV cancer compared with patients with non-AFP-SGC (P<0...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28753570/an-evaluation-of-nutrition-intervention-during-radiation-therapy-in-patients-with-locoregionally-advanced-nasopharyngeal-carcinoma
#19
Ting Jin, Kai-Xin Li, Pei-Jing Li, Shuang Huang, Xiao-Zhong Chen, Ming Chen, Qiao-Ying Hu, Lei Shi, Yuan-Yuan Chen
PURPOSE: To evaluate the effectiveness of nutrition intervention during radiation for patients with locoregionally advanced (III-IVa) nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: We retrospectively reviewed 117 patients with locoregionally advanced (III-IVa) NPC treated between December 2015 and March 2016 in Zhejiang Cancer Hospital. All the patients underwent radical chemo-radiotherapy. First, all the patients were divided into the nutrition intervention group and the control group, depending on whether they accepted nutrition intervention...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28752926/prognostic-nutritional-index-predicts-initial-response-to-treatment-and-prognosis-in-metastatic-castration-resistant-prostate-cancer-patients-treated-with-abiraterone
#20
Liancheng Fan, Xiao Wang, Chenfei Chi, Yanqing Wang, Wen Cai, Xiaoguang Shao, Fan Xu, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Shaowei Xie, Rui Wang, Lixin Zhou, Baijun Dong, Wei Xue
OBJECTIVE: To determine if prognostic nutritional index (PNI) and its variation could predict initial response to treatment and prognosis in metastatic castration-resistant prostate cancer (mCRPC) patients treated with Abiraterone (AA). PATIENTS AND METHODS: One-hundred-twelve chemotherapy pretreated or chemotherapy-naive patients were scheduled for systemic treatment with AA. PNI levels were measured before and after one month of AA treatment. Univariate and multivariate logistic regression analyses were used to identify predictive factors of initial response to AA treatment...
September 2017: Prostate
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