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https://www.readbyqxmd.com/read/28644887/sarcopenia-is-a-predictive-factor-for-intestinal-resection-in-admitted-patients-with-crohn-s-disease
#1
Shigeki Bamba, Masaya Sasaki, Azusa Takaoka, Kenichiro Takahashi, Hirotsugu Imaeda, Atsushi Nishida, Osamu Inatomi, Mitsushige Sugimoto, Akira Andoh
The relationship between skeletal muscle volume and the prognosis of patients with inflammatory bowel disease (IBD) remains undetermined. We conducted a retrospective study of 72 IBD patients who were admitted to the hospital due to disease exacerbation. We enrolled IBD patients who had undergone abdominal computed tomography and assessed the nutritional indices, such as the Onodera's prognostic nutritional index (O-PNI) and the controlling nutritional status (CONUT) index. The L3 skeletal muscle index (SMI), which is the ratio of the cross-sectional area of skeletal muscles at the level of the third lumbar (L3) vertebra to the height squared, was used to identify sarcopenia...
2017: PloS One
https://www.readbyqxmd.com/read/28638231/pleiotrophin-and-n-syndecan-promote-perineural-invasion-and-tumor-progression-in-an-orthotopic-mouse-model-of-pancreatic-cancer
#2
Jun Yao, Lu-Lin Zhang, Xu-Mei Huang, Wen-Yao Li, She-Gan Gao
AIM: To detect the expression of pleiotrophin (PTN) and N-syndecan in pancreatic cancer and analyze their association with tumor progression and perineural invasion (PNI). METHODS: An orthotopic mouse model of pancreatic cancer was created by injecting tumor cells subcapsularly in a root region of the pancreas beneath the spleen. Pancreatic cancer tissues were taken from 36 mice that survived for more than 90 d. PTN and N-syndecan proteins were detected by immunohistochemistry and analyzed for their correlation with pathological features, PNI, and prognosis...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28615804/the-neurochemistry-of-peripheral-nerve-regeneration
#3
Andreea Benga, Fatih Zor, Ahmet Korkmaz, Bogdan Marinescu, Vijay Gorantla
Peripheral nerve injuries (PNIs) can be most disabling, resulting in the loss of sensitivity, motor function and autonomic control in the involved anatomical segment. Although injured peripheral nerves are capable of regeneration, sub-optimal recovery of function is seen even with the best reconstruction. Distal axonal degeneration is an unavoidable consequence of PNI. There are currently few strategies aimed to maintain the distal pathway and/or target fidelity during regeneration across the zone of injury...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28615532/extranodal-extension-status-is-a-powerful-prognostic-factor-in-stage-iii-colorectal-cancer
#4
Chan Wook Kim, Jihun Kim, Seung-Seop Yeom, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Seunghee Baek, Chang Sik Yu, Jin Cheon Kim
PURPOSE: The present study aimed to evaluate the clinicopathologic characteristics of patients with extranodal extension (ENE) and the prognostic implications of ENE in stage III colorectal cancer (CRC). RESULTS: ENE was more frequent in younger patients and those with rectal cancer, higher T stage, higher N stage, lymphovascular invasion (LVI), and perineural invasion (PNI). Five-year disease-free survival (DFS) and overall survival (OS) were lower in patients with ENE-positive than in those with ENE-negative tumors (DFS, 66...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615514/prognostic-value-of-the-c-reactive-protein-prognostic-nutritional-index-ratio-after-hip-fracture-surgery-in-the-elderly-population
#5
Hanru Ren, Lianghao Wu, Wankun Hu, Xiuzhang Ye, Baoqing Yu
BACKGROUND: More and more older patients receive the surgery after hip fracture. However, the mortality rate is high. Prognostic nutritional index (PNI) is associated with prognosis in hip fracture patients. In the current study, we proposed a novel prognostic score, named c-reactive protein/PNI ratio (CRP/PNI ratio), for predicting the prognosis for geriatric orthopedic population. METHODS: This is a prospective study. Eighty cases of hip fracture surgery in the elderly population were studied to reveal the relationship between the CRP/PNI ratio and the clinicopathological characteristics of the elderly patients...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28607442/prognostic-nutritional-index-predicts-clinical-outcome-in-patients-with-acute-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#6
Qing-Jie Chen, Hui-Juan Qu, Dong-Ze Li, Xiao-Mei Li, Jia-Jun Zhu, Yang Xiang, Lei Li, Yi-Tong Ma, Yi-Ning Yang
We aimed to investigate whether the prognostic nutritional index (PNI), a combined nutritional-inflammatory score based on serum albumin levels and lymphocyte count, was associated with mortality in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). From September 2011 to November 2014, 309 consecutive patients with STEMI undergoing pPCI were prospectively enrolled. Patients with a combined score of albumin (g/L) + 5 × total lymphocyte count × 10(9)/L ≥ 45 or <45 were assigned a PNI score of 0 or 1, respectively...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28588447/the-effects-of-epidermal-neural-crest-stem-cells-on-local-inflammation-microenvironment-in-the-defected-sciatic-nerve-of-rats
#7
Yue Li, Dongdong Yao, Jieyuan Zhang, Bin Liu, Lu Zhang, Hua Feng, Bingcang Li
Cell-based therapy is a promising strategy for the repair of peripheral nerve injuries (PNIs). epidermal neural crest stems cells (EPI-NCSCs) are thought to be important donor cells for repairing PNI in different animal models. Following PNI, inflammatory response is important to regulate the repair process. However, the effects of EPI-NCSCs on regulation of local inflammation microenviroment have not been investigated extensively. In the present study, these effects were studied by using 10 mm defected sciatic nerve, which was bridged with 15 mm artificial nerve composed of EPI-NCSCs, extracellular matrix (ECM) and poly (lactide-co-glycolide) (PLGA)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28578683/preoperative-prognostic-nutritional-index-is-a-significant-predictor-of-survival-with-bladder-cancer-after-radical-cystectomy-a-retrospective-study
#8
Ding Peng, Yan-Qing Gong, Han Hao, Zhi-Song He, Xue-Song Li, Cui-Jian Zhang, Li-Qun Zhou
BACKGROUND: To explore the prognostic significance of preoperative prognostic nutritional index (PNI) in bladder cancer after radical cystectomy and compare the prognostic ability of inflammation-based indices. METHODS: We retrospectively analyzed data for 516 patients with bladder cancer who underwent radical cystectomy in our institution between 2006 to 2012. Clinicopathologic characteristics and inflammation-based indices (PNI, neutrophil/lymphocyte ratio [NLR], platelet/lymphocyte ratio [PLR], lymphocyte/monocyte ratio [LMR]) were evaluated by pre-treatment measurements...
June 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28576028/synthesis-and-characterization-of-eu-iii-complexes-of-modified-d-glucosamine-and-poly-n-isopropylacrylamide
#9
Guihua Cui, Yu Bai, Wenliang Li, Zhengguo Gao, Shuiying Chen, Nannan Qiu, Toshifumi Satoh, Toyoji Kakuchi, Qian Duan
A series of chain-end functional polymers composed of poly(N-isopropylacrylamide) (PNIPAM) and 2-amino-2-deoxy-d-glucopyranose(d-glucosamine, GA) was synthesized via atom transfer radical polymerization (ATRP). Novel fluorescent complexes of glucosamine-PNI- PAM/Eu(III) were then formed by chelation of the polymers and europium(III) ions. The aqueous solutions of the polymers and its Eu(III) complexes exhibited a lower critical solution temperatures (LCSTs), and which were approximately equal to body temperature...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28575242/prognostic-significance-of-the-prognostic-nutritional-index-in-esophageal-cancer-patients-undergoing-neoadjuvant-chemotherapy
#10
M Nakatani, K Migita, S Matsumoto, K Wakatsuki, M Ito, H Nakade, T Kunishige, M Kitano, H Kanehiro
Nutritional status is one of the most important issues faced by cancer patients. Several studies have shown that a low preoperative nutritional status is associated with a worse prognosis in patients with various types of cancer, including esophageal cancer (EC). Recently, neoadjuvant chemotherapy (NAC) and/or radiotherapy have been accepted as the standard treatment for resectable advanced EC. However, NAC has the potential to deteriorate the nutritional status of a patient. This study aimed to evaluate the prognostic significance of the nutritional status for EC patients who underwent NAC...
August 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28569598/associations-between-nutritional-parameters-and-clinicopathologic-factors-in-patients-with-gastric-cancer-a-comprehensive-study
#11
Adam Brewczyński, Beata Jabłońska, Krzysztof Pawlicki
The aim of this study was to assess and analyze the nutritional status of gastric cancer (GC) patients. The analysis included 207 patients with GC treated in a large center of oncology. Patients were divided into two groups according to the cutoff value of the mean prognostic nutritional index (PNI): those with a PNI < 52.78 and those with a PNI ≥ 52.78. The higher PNI was associated with lower age and higher total protein and hemoglobin levels (P < 0.01). The total lymphocyte count (P = 0.02), albumin, total protein and PNI (P < 0...
June 1, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28562824/insect-galls-of-the-parque-nacional-do-itatiaia-southeast-region-brazil
#12
Valéria C Maia, Bernardo Mascarenhas
The Parque Nacional do Itatiaia (PNI) (Brazilian Southeast Region) was surveyed monthly for insect galls from February/2014 to December/ 2015. A total of 432 gall morphotypes were found. This number places the PNI as the richest Atlantic forest area in number of gall morphotypes. The galls were found on 47 plant families. Among them, Asteraceae were pointed out as the superhost. The gall richness in the lower part of the PNI is higher than that of the plateau. The insect galls were found in 154 native, 56 endemic and only one exotic plant species...
May 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28561270/barriers-to-generating-pdx-models-of-hpv-related-head-and-neck-cancer
#13
Nicole D Facompre, Varun Sahu, Kathleen T Montone, Kayla M Harmeyer, Hiroshi Nakagawa, Anil K Rustgi, Gregory S Weinstein, Phyllis A Gimotty, Devraj Basu
OBJECTIVES/HYPOTHESIS: Delineate factors impacting the creation and use of patient-derived xenografts (PDXs) of human papilloma virus-related (HPV+) head and neck squamous cell carcinomas (HNSCCs). STUDY DESIGN: Laboratory-based translational study. METHODS: Fifty-one surgically resected HNSCCs, including 31 HPV + cancers, were implanted into NOD/SCID/IL-2Rγ(-/-) (NSG) mice using standardized methodology. Clinical and pathologic factors were tested for association with engraftment...
May 31, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28559119/clinicopathologic-features-and-prognostic-implications-of-mybl2-protein-expression-in-pancreatic-ductal-adenocarcinoma
#14
Ranjie Yu, Chengyi Li, Xiaomei Lin, Qun Chen, Jie Li, Li Song, Lin Lin, Jingnan Liu, Yan Zhang, Wencui Kong, Xuenong Ouyang, Xiong Chen
MYBL2 (B-MYB), a member of the MYB family of transcription factor genes, regulates the expression of genes in the process of tumorigenesis. Many studies have shown that MYBL2 is high expresssion in several human malignancies including pancreatic ductal adenocarcinoma (PDAC). However, its role in PDAC is still unclear. The present study is designed to investigate MYBL2 expression levels and prognostic significance in PDAC patients. We assessed MYBL2 expression level by immunohistochemistry in tumor tissues from 93 PDAC patients undergoing curative resection...
May 4, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28556902/comparison-of-the-prognostic-values-of-selected-inflammation-based-scores-in-patients-with-medullary-thyroid-carcinoma-a-pilot-study
#15
Ke Jiang, Jianyong Lei, Canjun Li, Kunpeng Shu, Wenbin Li, Yuwei Zhang, Zhihui Li, Rixiang Gong, Jingqiang Zhu
BACKGROUND: The significance of inflammation based scores including the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), and plasma fibrinogen remains unclear in medullary thyroid carcinoma (MTC). We aimed to compare the prognostic value of these scores. METHODS: Seventy-eight patients newly diagnosed as MTC with operation in our institution from May 2009 to September 2016 were retrospectively evaluated...
May 29, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28555306/prognostic-value-of-perineural-invasion-in-resected-gastric-cancer-patients-according-to-lauren-histotype
#16
Lorenzo De Franco, Daniele Marrelli, Costantino Voglino, Carla Vindigni, Francesco Ferrara, Giulio Di Mare, Livio Iudici, Mario Marini, Franco Roviello
The purpose of this study is to investigate perineural invasion (PNI) as a prognostic factor in gastric cancer patients. 455 patients submitted to extended (D2 or more) lymphadenectomy (median number of 39 retrieved lymph nodes, range: 15-140) between 1995 and 2012 were retrospectively studied. Patients were categorized in two groups according to the PNI status, and PNI positivity was assessed in presence of cancer cells in the perinerium or the neural fascicles using hematoxylin and eosin staining. Median follow-up for surviving patients was 80...
May 30, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28549896/concordance-among-methods-of-nutritional-assessment-in-patients-included-on-the-waiting-list-for-liver-transplantation
#17
María Teresa García-Rodríguez, Beatriz López-Calviño, María Del Carmen Piñón-Villar, Alejandra Otero-Ferreiro, Francisco Suárez-López, Manuel Gómez-Gutiérrez, Sonia Pértega-Díaz, María Teresa Seoane-Pillado, Salvador Pita-Fernández
BACKGROUND: The aim of the present study was to determine the extent of malnutrition in patients waiting for a liver transplant. The agreement among the methods of nutritional assessment and their diagnostic validity were evaluated. METHODS: Patients on the waiting list for liver transplantation (n = 110) were studied. The variables were: body mass index, analytical parameters, liver disease etiology, and complications. Liver dysfunction was evaluated using the Child-Pugh Scale...
May 23, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28537767/assessing-dimensions-of-pathological-narcissism-psychometric-properties-of-the-short-form-of-the-five-factor-narcissism-inventory-in-a-sample-of-italian-university-students
#18
Andrea Fossati, Antonella Somma, Serena Borroni, Joshua D Miller
To evaluate the psychometric properties of the Italian translation of the Five-Factor Narcissism Inventory-Short Form (FFNI-SF), 1,063 Italian university students were administered the scale, along with the Pathological Narcissism Inventory (PNI) and the Measure of Disordered Personality Functioning (MDPF). In general, the FFNI-SF scales showed good internal consistency (median α = .76; median interitem r = .44) and structural analyses suggested a 3-component model of FFNI-SF scales that was similar to that reported by Sherman et al...
May 24, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28534554/-relation-between-preoperative-prognostic-onodera-s-index-and-postsurgery-complications-in-the-r0-gastric-carcinoma-resection
#19
F Borda, C Miranda, A Borda, E Echeverría, A Guerra, J J Iñigo, J M Zozaya
BACKGROUND: It has been postulated in the Asian literature that a low prognostic nutritional index (OI) could be associated with a higher rate of complications following radical gastric cancer surgery, but there is a lack of data concerning western countries. The aim is to analyze the relationship between a low preoperative OI and the frequency and severity of surgical complications in R0 gastric cancer resection. PATIENTS AND METHODS: In the present article, 124 cases of gastric cancer with R0 resection were reviewed...
April 30, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28528911/role-of-microscopic-spread-beyond-gross-disease-as-an-adverse-prognostic-factor-in-oral-squamous-cell-carcinoma
#20
A Mishra, S Datta, A Malik, A Garg, D Nair, S Nair, M Mair, M Bal, J Agarwal, P Chaturvedi
INTRODUCTION: Despite meticulous surgery and proper adjuvant treatment, outcome of oral squamous cell carcinoma remains unpredictable. This shows that there may be other factors which should be considered while prognosticating these patients. Many a times there is spread of disease beyond the gross margin which can alter the margin status. We hypothesized that microscopic spread beyond gross disease may portend a poor prognosis. METHOD: This is a retrospective study of prospectively collected data of 1025 treatment naïve oral squamous cell carcinoma patients...
May 6, 2017: European Journal of Surgical Oncology
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