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https://www.readbyqxmd.com/read/28223828/preoperative-albumin-to-globulin-ratio-and-prognostic-nutrition-index-predict-prognosis-for-glioblastoma
#1
Wen-Zhe Xu, Feng Li, Zhen-Kuan Xu, Xuan Chen, Bin Sun, Jing-Wei Cao, Yu-Guang Liu
OBJECTIVE: Impaired immunonutritional status has disadvantageous effects on outcomes for cancer patients. Preoperative albumin-to-globulin ratio (AGR) and the prognostic nutrition index (PNI) have been used as prognostic factors in various cancers. We aimed to evaluate the clinical significance of the AGR and PNI in glioblastoma. MATERIALS AND METHODS: This retrospective analysis involved 166 patients. Demographic, clinical, and laboratory data were collected. AGR and the PNI were calculated as AGR = albumin/(total serum protein - albumin) and PNI = albumin (g/L) + 5 × total lymphocyte count (10(9)/L)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28223016/lymph-node-involvement-predicts-poor-prognosis-in-primary-tongue-adenoid-cystic-carcinoma-a-preliminary-study-of-54-cases
#2
Nannan Han, Huishan Ong, Zhihui Liu, Min Ruan, Wenjun Yang, Chenping Zhang
PURPOSE: Primary tongue adenoid cystic carcinoma (ACC) is extremely rare. The relationship between the patient's prognosis and the tumor's clinicopathological characteristics is uncertain. The aim of this study was to identify the prognostic factors and analyze the overall outcomes for patients with tongue ACC. PATIENTS AND METHODS: A retrospective analysis of the medical records of patients diagnosed with primary tongue ACC between 1998 and 2008 was conducted. The study comprised 54 patients, with a median age of 53...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28219213/-clinical-application-value-of-prognostic-nutritional-index-for-predicting-survival-in-patients-with-advanced-non-small-cell-lung-cancer
#3
W J Xu, Y M Kang, L Zhou, F F Chen, Y H Song, C Q Zhang
Objective: To explore the clinical application value of prognostic nutritional index(PNI) for predicting overall survival(OS) in patients with advanced non-small cell lung cancer (NSCLC). Methods: 123 patients with histologically confirmed non-small cell lung cancer were enrolled in this study, and their clinical and laboratory data were reviewed. The PNI was calculated as 10×serum albumin value+ 5×total lymphocyte countin peripheral blood.Univariate and multivariate analyses were used to identify the potential prognostic factors for advanced NSCLC...
February 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28215306/neurotrophin-receptors-and-perineural-invasion-analyses-in-select-lineage-unrelated-cutaneous-malignancies-with-a-propensity-for-perineural-invasion
#4
N F Frydenlund, M Mahalingam
In this chapter, we parse the literature on neurotrophins that have been implicated in the pathogenesis of perineural invasion (PNI) in select lineage-unrelated malignancies. We also detail evidence linking neurotrophins and their receptors (TrkA, RET, p75NGFR, and NCAM) to the pathogenesis of PNI in desmoplastic melanoma and cutaneous squamous cell carcinoma-both malignancies with an established propensity for PNI. Lastly, the clinical potential of neurotrophins as receptors for targeted therapies is explored...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28213742/comparison-of-systemic-inflammatory-and-nutritional-scores-in-colorectal-cancer-patients-who-underwent-potentially-curative-resection
#5
Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Daisuke Izumi, Keisuke Kosumi, Katsunobu Taki, Takaaki Higashi, Tatsunori Miyata, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
BACKGROUND: Various systemic inflammatory and nutritional scores have been reported to predict postoperative outcomes. This study aimed to investigate the best systemic inflammatory and nutritional scores in colorectal cancer (CRC) patients who underwent potentially curative resection. METHOD: We evaluated 468 consecutive CRC patients in this study. Comparisons of systemic inflammatory and nutritional scores, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS), were performed using univariate/multivariate analyses for patient survival...
February 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28204965/prognostic-value-of-simple-frailty-and-malnutrition-screening-tools-in-patients-with-acute-heart-failure-due-to-left-ventricular-systolic-dysfunction
#6
S Sze, J Zhang, P Pellicori, D Morgan, A Hoye, A L Clark
BACKGROUND: Frailty and malnutrition are common in patients with heart failure (HF), and are associated with adverse outcomes. We studied the prognostic value of three malnutrition and three frailty indices in patients admitted acutely to hospital with HF. METHODS: 265 consecutive patients [62% males, median age 80 (interquartile range (IQR): 72-86) years, median NTproBNP 3633 (IQR: 2025-6407) ng/l] admitted with HF between 2013 and 2014 were enrolled. Patients were screened for frailty using the Derby frailty index (DFI), acute frailty network (AFN) frailty criteria, and clinical frailty scale (CFS) and for malnutrition using the geriatric nutritional risk index (GNRI), controlling nutritional status (CONUT) score and prognostic nutritional index (PNI)...
February 15, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28195087/perineural-invasion-is-a-valuable-prognostic-factor-in-advanced-stage-and-or-node-cervical-cancer
#7
Cigdem Vural, Busra Yaprak Bayrak, Bahar Muezzınoglu, Izzet Yucesoy
BACKGROUND: Perineural invasion (PNI) is correlated with adverse survival in several malignancies, but its significance cervical cancer remains to be clearly defined. The objective of this study was to determine the association between PNI status and clinical outcomes in clinically localized surgically treated cervical cancers. MATERIALS AND METHODS: We reviewed clinical records and pathology slides of 111 patients with cervical cancer treated with surgery at a single academic center...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28188750/kras-and-pik3ca-mutations-in-colorectal-adenocarcinomas-correlate-with-aggressive-histological-features-and-behavior
#8
Sejin Jang, Mineui Hong, Mi Kyung Shin, Byung Chun Kim, Hyung-Sik Shin, Eunsil Yu, Seung-Mo Hong, Jihun Kim, Sung Min Chun, Tae-Im Kim, Kyung-Chan Choi, Young Woong Ko, Jeong Won Kim
Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition (EMT) and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli (LVE), perineural invasion (PNI), and an infiltrative growth pattern. Mutations in the genes of the Ras-MAPK and PI3K pathways are associated with EMT and an aggressive CRC phenotype and have been used in patient stratification for anti-EGF receptor therapies; however, the impact of these mutations on CRC morphology and behavior remains unclear...
February 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28185108/low-prognostic-nutritional-index-associated-with-cardiovascular-disease-mortality-in-incident-peritoneal-dialysis-patients
#9
Fenfen Peng, Wenjing Chen, Weidong Zhou, Peilin Li, Hongxin Niu, Yihua Chen, Yan Zhu, Haibo Long
PURPOSE: The prognostic nutritional index (PNI), a variable based on serum albumin concentration and total lymphocyte count in peripheral blood, is reported as a predictor of mortality in a variety of malignant tumor population. This study is aimed to evaluate whether PNI has prognostic value in patients on peritoneal dialysis (PD). METHODS: This was a single-center, retrospective observational cohort study conducted in incident PD patients from January 1, 2006 to June 30, 2014, and followed until June 30, 2015...
February 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28181952/perineural-pseudoinvasion-an-unusual-phenomenon-in-nonmalignancies
#10
Mansour Moghimi, Fatemeh Joukar, Amin Salehi-Abargouei, Mohammad-Reza Mozayan, Amir Aryanfar
Perineural invasion (PNI) is characterized as tumoral or nontumoral cells invading in or around the nerves. The neural invasion is considered as a histopathologic characteristic for malignancy and is considered a mechanism for its spread. Both of these patterns usually portend a poor prognosis and very often are markers to prompt additional treatment. There are also some nonmalignancies representing PNI, including benign neoplasms, mimicking lesions, and disorders, such as chronic pancreatitis and endometriosis...
March 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28174485/prognostic-nutritional-index-is-an-independent-prognostic-factor-for-gastric-cancer-patients-with-peritoneal-dissemination
#11
Runcong Nie, Shuqiang Yuan, Shi Chen, Xiaojiang Chen, Yongming Chen, Baoyan Zhu, Haibo Qiu, Zhiwei Zhou, Junsheng Peng, Yingbo Chen
OBJECTIVE: The predictive and prognostic role of prognostic nutritional index (PNI) in gastric cancer patients with peritoneal dissemination remains unclear. This study aims to explore the role of the PNI in predicting outcomes of gastric cancer patients with peritoneal dissemination. METHODS: A total of 660 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis between January 2000 and April 2014 at Sun Yat-sen University Cancer Center and the Sixth Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28159523/a-novel-automated-somatosensory-evoked-potential-ssep-monitoring-device-for-detection-of-intraoperative-peripheral-nerve-injury-in-cardiac-surgery-a-clinical-feasibility-study
#12
Jason Chui, John M Murkin, Timothy Turkstra, Neil McKenzie, Linrui Guo, Mackenzie Quantz
OBJECTIVE: Peripheral nerve injury (PNI) is a common and potentially devastating complication in cardiac surgery. Somatosensory evoked potential (SSEP) monitoring is one of the modalities for PNI; however, its application is limited by complicated logistics. This study aimed to assess the feasibility of using a novel, automated SSEP device (EPAD; SafeOp Surgical, Hunt Valley, MD) for detection of intraoperative PNI during cardiac surgery. DESIGN: Prospective, observational study...
November 17, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28133046/-preoperative-prognostic-nutritional-index-in-elderly-patients-over-80-years-old-who-underwent-curative-resection-for-colorectal-cancer
#13
Kazuhiko Yoshimatsu, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Akiko Sakuma, Masaya Satake, Masano Sagawa, Atsuo Matsumoto, Takashi Fjimoto, Shinichi Asaka, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
PATIENTS AND METHODS: From 2001, cases of 76 patients who underwent Cur A resection for colorectal cancer and preoperative prognostic nutritional index (PNI) assessment were analyzed in terms of clinicopathological factors, surgical outcomes, and prognosis. RESULTS: Median age of the 36 men and 40 women included in the study was 83 years. Median PNI was 42.1. Twenty-four patients had a PNI below 40. There were 36 patients with pulmonary dysfunction, and 60 patients with D2 or wider LN dissection...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28120500/median-and-ulnar-nerve-injuries-reduce-volitional-forelimb-strength-in-rats
#14
Eric C Meyers, Rafael Granja, Bleyda R Solorzano, Mario Romero-Ortega, Michael P Kilgard, Robert L Rennaker, Seth Hays
Introduction Peripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited. Robust animal models are critical first steps for developing effective therapies to restore function after PNI. Methods We developed an automated behavioral assay that provides quantitative measurements of volitional forelimb strength in rats. Multiple forelimb PNI models involving the median and ulnar nerves were used to assess forelimb function for up to 13 weeks post-injury...
January 24, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28119863/prognostic-impact-of-immunonutritional-status-changes-during-preoperative-chemoradiation-in-patients-with-rectal-cancer
#15
Yong Joon Lee, Woo Ram Kim, Jeonghee Han, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Nam Kyu Kim, Byung Soh Min
PURPOSE: Previous studies have demonstrated the prognostic impact of the prognostic nutritional index (PNI), a proposed indicator of immunonutritional statuses of surgical patients, on patients with various gastrointestinal cancers. Although the prognostic impact of the PNI on patients with colorectal cancer has been well established, its value has not been studied in patients treated with preoperative chemoradiation (pCRT). This study aimed to evaluate the prognostic impact of PNI on patients receiving pCRT for locally advanced rectal cancer (LARC)...
December 2016: Annals of Coloproctology
https://www.readbyqxmd.com/read/28117782/a-model-for-perineural-invasion-in-head-and-neck-squamous-cell-carcinoma
#16
Phillip Huyett, Mark Gilbert, Lijun Liu, Robert L Ferris, Seungwon Kim
Perineural invasion (PNI) is found in approximately 40% of head and neck squamous cell carcinomas (HNSCC). Despite multimodal treatment with surgery, radiation, and chemotherapy, locoregional recurrences and distant metastases occur at higher rates, and overall survival is decreased by 40% compared to HNSCC without PNI. In vitro studies of the pathways involved in HNSCC PNI have historically been challenging given the lack of a consistent, reproducible assay. Described here is the adaptation of the dorsal root ganglion (DRG) assay for the examination of PNI in HNSCC...
January 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28109322/adar1-overexpression-is-associated-with-cervical-cancer-progression-and-angiogenesis
#17
Ying Chen, He Wang, Wenyi Lin, Ping Shuai
BACKGROUND: This study aimed to assess the role of RNA-dependent adenosine deaminase (ADAR1) in cervical squamous cell carcinoma occurrence and progression. METHODS: ADAR1 expression levels in stage IA and stage IIA cervical squamous cell carcinoma (group A), cervical intraepithelial neoplasia (CIN) specimens (group B), as well as normal and inflamed cervical tissue samples (group C) were assessed by immunohistochemistry. Clinical and pathological data of cervical squamous cell carcinoma patients undergoing surgery were retrospectively evaluated...
January 21, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28105622/-association-of-peripheral-nerve-invasion-with-clinicopathological-factors-and-prognosis-of-colorectal-cancer
#18
Dong Han, Ying Wei, Xidi Wang, Geng Wang, Yinggang Chen
OBJECTIVE: To investigate the association of peripheral nerve invasion (PNI) with clinicopathological factors and prognosis of colorectal cancer. METHODS: Clinicopathological data and Surgical specimens of 372 colorectal cancer patients who underwent radical resection from January 2011 to June 2012 in The Second Affiliated Hospital of Harbin Medical University were collected. Histopathological evaluation of tissue samples was conducted with hematoxylin and eosin-stained sections...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28105355/evaluation-of-prognostic-markers-for-patients-with-curatively-resected-thoracic-esophageal-squamous-cell-carcinomas
#19
Masahide Ikeguchi, Yusuke Kouno, Kyoichi Kihara, Kazunori Suzuki, Kanenori Endo, Seiichi Nakamura, Takashi Sawada, Tetsu Shimizu, Tomoyuki Matsunaga, Yoji Fukumoto, Hiroaki Saito
The Glasgow Prognostic Score (GPS), neutrophil/lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are prognostic parameters for malignancies. Additionally, serum squamous cell carcinoma antigen (SCC-Ag) and cytokeratin 19 fragments (CYFRA 21-1) are tumor markers for squamous cell carcinoma. In the present study, the prognostic importance of these markers in patients with resectable thoracic esophageal cancer was investigated. In this retrospective study, 84 enrolled patients diagnosed with resectable clinical stage I-III thoracic esophageal squamous cell carcinomas (ESCCs) underwent thoracic esophageal resection and three-field lymph node dissection at Tottori University Hospital between January 2007 and December 2013...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28103913/prognostic-histological-factors-in-patients-with-esophageal-squamous-cell-carcinoma-after-preoperative-chemoradiation-followed-by-surgery
#20
Cheng-Che Tu, Po-Kuei Hsu, Ling-I Chien, Wan-Chen Liu, Chien-Sheng Huang, Chih-Cheng Hsieh, Han-Shui Hsu, Yu-Chung Wu
BACKGROUND: Pathological response is an important marker for tumor aggressiveness in patients with esophageal squamous cell carcinoma (ESCC) who receive preoperative chemoradiation followed by esophagectomy. We aim to evaluate the prognostic value of histological factors after trimodality treatments. METHODS: 91 patients who received preoperative chemoradiation followed by transthoracic esophagectomy between 2009 and 2014 were included. The pathological examination was reviewed...
January 19, 2017: BMC Cancer
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