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https://www.readbyqxmd.com/read/28329246/lymphovascular-invasion-and-extracapsular-invasion-are-risk-factors-for-distant-recurrence-after-preoperative-chemoradiotherapy-and-oesophagectomy-in-patients-with-oesophageal-squamous-cell-carcinoma
#1
Po-Kuei Hsu, Ling-I Chien, Lei-Chi Wang, Teh-Ying Chou
OBJECTIVES: Patients with oesophageal squamous cell carcinoma have a high risk of disease recurrence even after trimodality treatments, which include preoperative chemoradiotherapy and oesophagectomy. We aimed to identify the histological factors that are associated with loco-regional and distant recurrence. METHODS: A retrospective review of a prospectively established database identified patients who received preoperative chemoradiotherapy and oesophagectomy for squamous cell carcinoma...
February 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28322123/factors-associated-with-recurrence-and-regional-adenopathy-for-head-and-neck-cutaneous-squamous-cell-carcinoma
#2
Brianna N Harris, Ahmed Bayoumi, Shyam Rao, Michael G Moore, D Gregory Farwell, Arnaud F Bewley
Objective Cutaneous squamous cell carcinoma (CSCC) is one of the most common malignancies worldwide. With advanced CSCC of the head and neck, there is conflicting evidence on what constitutes high-risk disease. Our objective is to evaluate which factors are predictive of recurrence and nodal spread and survival. Study Design Case series with chart review. Setting Tertiary academic institution. Subjects and Methods Patients with advanced head and neck CSCC treated with primary resection identified by chart review...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28321381/skull-base-invasion-patterns-and-survival-outcomes-of-nonmelanoma-skin-cancers
#3
Yusuf Dundar, Richard B Cannon, Marcus M Monroe, Luke Oliver Buchmann, Jason Patrick Hunt
Objective Report routes of skull base invasion for head and neck nonmelanoma skin cancers (NMSCs) and their survival outcomes. Design Retrospective. Participants Ninety patients with NMSC with skull base invasion between 2004 and 2014. Major Outcome Measures Demographic, tumor characteristics, and treatments associated with different types of skull base invasion and disease-specific survival (DSS) and overall survival (OS). Results Perineural invasion (PNI) to the skull base occurred in 69% of patients, whereas 38% had direct skull base invasion...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28315180/inflammation-based-indexes-and-clinicopathologic-features-are-strong-predictive-values-of-preoperative-circulating-tumor-cell-detection-in-gastric-cancer-patients
#4
L Zheng, K Zou, C Yang, F Chen, T Guo, B Xiong
PURPOSE: Circulating tumor cell (CTC) count and the host inflammatory response are two independent predictors for patients with various malignant disease. Several inflammation-based indicators have been demonstrated to have prognostic value in many malignant solid tumors, including systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and prognostic nutrition index (PNI). The aim of this study was to evaluate the predictive value of the inflammation-based indexes including SII, NLR PLR, and PNI for CTC detection of gastric cancer patients before surgery...
March 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28315008/the-optimal-cut-off-value-of-the-preoperative-prognostic-nutritional-index-for-the-survival-differs-according-to-the-tnm-stage-in-hepatocellular-carcinoma
#5
Yukiyasu Okamura, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhiko Uesaka
PURPOSE: To establish the optimal cut-off value of the preoperative prognostic nutritional index (PNI) for prognosis according to the Tumor Node Metastasis (TNM) stage of hepatocellular carcinoma (HCC) after curative resection. METHODS: This retrospective study reviewed the records of 375 patients. The optimal cut-off value of the PNI was established according to the TNM stage, and overall survival was compared between the low and high PNI groups. RESULTS: The optimal cut-off value of the PNI decreased with increasing TNM stage, with 52, 47, and 43 patients having stage I, II, and III HCC, respectively...
March 17, 2017: Surgery Today
https://www.readbyqxmd.com/read/28301959/utility-of-clinico-biological-data-for-long-term-prognosis-of-head-and-neck-terminal-cancer
#6
Taiji Kawasaki, Koichiro Wasano, Sayuri Yamamoto, Shuta Tomisato, Kaoru Ogawa
OBJECTIVE: The prognosis of terminal head and neck cancer is traditionally determined using indices such as the palliative prognosis index. We aimed to develop an alternative prognosis index using clinico-biological data. METHODS: This retrospective case-series study included 33 head and neck cancer patients whose cancer recurred despite receiving radiation therapy between April 2010 and April 2014. Clinico-biological data were collected the day patients were diagnosed as terminal...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28293741/influence-of-prognostic-nutritional-index-and-tumor-markers-on-survival-in-gastric-cancer-surgery-patients
#7
Hiroaki Saito, Yusuke Kono, Yuki Murakami, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki
PURPOSE: Blood analytes are easily used in routine clinical practice. Tumor markers (TMs) are useful in diagnosing, treating, and predicting prognosis of gastric cancer (GC). The prognostic nutritional index (PNI) was also recently found to be useful in predicting GC prognosis. METHODS: The PNI and serum levels of CEA and CA19-9 of 453 patients with GC were measured to examine correlations between those levels and patients' prognoses. RESULTS: Of the 453 patients, 84 (18...
March 15, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28287320/preoperative-prognostic-nutritional-index-correlates-with-severe-complications-and-poor-survival-in-patients-with-colorectal-cancer-undergoing-curative-laparoscopic-surgery-a-retrospective-study-in-a-single-chinese-institution
#8
Xianglong Cao, Gang Zhao, Tao Yu, Qi An, Hua Yang, Gang Xiao
The prognostic nutritional index (PNI) has been correlated with long-term outcomes in cancer patients. However, the relationship between PNI, the postoperative complications, and long-term outcomes in patients with colorectal cancer (CRC) undergoing curative laparoscopic surgery has not been fully investigated. This retrospective study was conducted in the Beijing Hospital between January 2009 and January 2012. A total of 228 patients diagnosed with primary CRC undergoing curative laparoscopic surgery in the center were analyzed...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28271999/postoperative-radiotherapy-in-salivary-gland-carcinoma-a-single-institution-experience
#9
Öztun Temelli, Ersoy Kekilli, Ahmet Kizilay
BACKGROUND: Salivary gland carcinoma are rare tumors and the main treatment is surgical. The addition of radiotherapy to surgery decreases locoregional relapses in high risk patients. Aim of our study is to retrospectively evaluate local control and survival and the factors affecting them in patients who received postoperative radiotherapy. MATERIALS AND METHODS: The medical records of 30 patients with salivary gland tumors operated on and referred to our clinic for adjuvant RT between January 2004 and June 2015 were retrospectively evaluated...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28256609/prognosis-and-progression-of-escc-patients-with-perineural-invasion
#10
Guanghui Xu, Fan Feng, Zhen Liu, Shushang Liu, Gaozan Zheng, Shuao Xiao, Lei Cai, Xuewen Yang, Guocai Li, Xiao Lian, Man Guo, Li Sun, Jianjun Yang, Daiming Fan, Qun Lu, Hongwei Zhang
Perineural invasion (PNI) has been recognized as a poor prognostic factor in several malignancies, but the definition and pathogenesis of PNI in esophageal squamous cell carcinoma (ESCC) remains to be defined. PNI was evaluated by H&E staining and S100 immunohistochemistry. The predictive value of PNI in the prognosis of ESCC patients was analyzed. PNI was evaluated in vitro and in vivo. A total of 54 specimens (17.88%) were defined as PNI-a and 99 specimens (32.78%) as PNI-b. S100 staining was superior to H&E staining for PNI detection (50...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251372/a-decrease-in-the-prognostic-nutritional-index-is-associated-with-a-worse-long-term-outcome-in-gastric-cancer-patients-undergoing-neoadjuvant-chemotherapy
#11
Kazuhiro Migita, Sohei Matsumoto, Kohei Wakatsuki, Masahiro Ito, Tomohiro Kunishige, Hiroshi Nakade, Mutsuko Kitano, Mitsuhiro Nakatani, Hiromichi Kanehiro
PURPOSE: The aim of this study was to evaluate the prognostic impact of the prognostic nutritional index (PNI) in gastric cancer patients undergoing neoadjuvant chemotherapy (NAC). METHODS: This study reviewed 54 patients with gastric cancer who underwent NAC and a subsequent R0 gastrectomy. The PNI before starting NAC and before gastrectomy were calculated using the following formula: 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (per mm(3))...
March 1, 2017: Surgery Today
https://www.readbyqxmd.com/read/28251222/high-preoperative-serum-ferritin-predicted-poor-prognosis-in-non-metastatic-colorectal-cancer
#12
Hong Tingting, Shen Di, Chen Xiaoping, Wu Xiaohong, Hua Dong
To validate the prognostic significance of preoperative serum iron metabolism parameters in non-metastatic colorectal cancer patients treated with curative resection.   Methods: We conducted a prospective cohort study in the Department of Surgical Oncology, WuXi 4th People's Hospital, WuxiChina, between  March 2010 and September 2013.  The relationships of serum iron metabolism parameters with other variables were examined. The prognostic significance was evaluated using the Kaplan Meier curve and Cox proportional hazards regression model...
March 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28250739/platelet-rich-plasma-an-adjuvant-biological-therapy-to-assist-peripheral-nerve-repair
#13
REVIEW
Mikel Sánchez, Ane Garate, Diego Delgado, Sabino Padilla
Therapies such as direct tension-free microsurgical repair or transplantation of a nerve autograft, are nowadays used to treat traumatic peripheral nerve injuries (PNI), focused on the enhancement of the intrinsic regenerative potential of injured axons. However, these therapies fail to recreate the suitable cellular and molecular microenvironment of peripheral nerve repair and in some cases, the functional recovery of nerve injuries is incomplete. Thus, new biomedical engineering strategies based on tissue engineering approaches through molecular intervention and scaffolding offer promising outcomes on the field...
January 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28247035/the-value-of-the-prognostic-nutritional-index-pni-in-predicting-outcomes-and-guiding-the-treatment-strategy-of-nasopharyngeal-carcinoma-npc-patients-receiving-intensity-modulated-radiotherapy-imrt-with-or-without-chemotherapy
#14
Jingjing Miao, Weiwei Xiao, Lin Wang, Fei Han, Haijun Wu, Xiaowu Deng, Xiang Guo, Chong Zhao
PURPOSE: The purpose of this study was to investigate the significance of the Prognostic Nutritional Index (PNI) in predicting prognoses and guiding treatment choices of nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy (IMRT). METHODS: The 539 patients with newly diagnosed non-metastatic NPC were retrospectively analysed. The PNI was calculated as 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm(3))...
February 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28243747/impact-of-the-prognostic-nutritional-index-on-the-recovery-and-long-term-oncologic-outcome-of-patients-with-colorectal-cancer
#15
Gyoung Tae Noh, Jeonghee Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
PURPOSE: The prognostic nutritional index (PNI) has been reported to be a predictive marker for surgical outcomes and prognosis in gastrointestinal malignancies. In this study, we aimed to identify the impact of preoperative PNI on the recovery and long-term oncologic outcome of patients with colorectal cancer (CRC). METHODS: A total of 3569 patients who underwent curative resection for CRC were enrolled, and their medical records were analyzed retrospectively. Preoperative PNI was calculated as 10× serum albumin concentration (g/dL) + 0...
February 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28242042/eukaryotic-translation-initiation-factor-4e-eif-4e-expressions-are-associated-with-poor-prognosis-in-colorectal-adenocarcinoma
#16
Yi-Ting Chen, Hung-Pei Tsai, Chun-Chieh Wu, Jaw-Yuan Wang, Chee-Yin Chai
Both phosphorylated 4E binding protein 1 (p-4E-BP1) and eukaryotic translation initiation factor 4E (eIF-4E) play an important role in cancer progression. The aim of this study is to evaluate the expression of p-4E-BP1 and eIF-4E in human colorectal cancer (CRC) and to assess their clinical significance. Expression levels of two markers were analyzed in surgical specimens from 116 CRC cases by immunohistochemical staining. Their clinical significance as well as the two proteins' correlation was also investigated...
February 14, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28239339/microarray-and-qpcr-analyses-of-wallerian-degeneration-in-rat-sciatic-nerves
#17
Sheng Yi, Xin Tang, Jun Yu, Jie Liu, Fei Ding, Xiaosong Gu
Wallerian degeneration occurs immediately following injury to mammal peripheral nerves. To better understand the molecular events occurring during Wallerian degeneration, a rat model of sciatic nerve transection was used to assess differentially expressed genes at 0.5, 1, 6, 12, 24 h, 4 days, 1, 2, 3, and 4 weeks post nerve injury (PNI). Hierarchical clustering, Euclidean distance matrix, and principal component analysis (PCA) collectively suggested three distinct phases within the post-injury period of 4 weeks...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28223828/preoperative-albumin-to-globulin-ratio-and-prognostic-nutrition-index-predict-prognosis-for-glioblastoma
#18
Wen-Zhe Xu, Feng Li, Zhen-Kuan Xu, Xuan Chen, Bin Sun, Jing-Wei Cao, Yu-Guang Liu
OBJECTIVE: Impaired immunonutritional status has disadvantageous effects on outcomes for cancer patients. Preoperative albumin-to-globulin ratio (AGR) and the prognostic nutrition index (PNI) have been used as prognostic factors in various cancers. We aimed to evaluate the clinical significance of the AGR and PNI in glioblastoma. MATERIALS AND METHODS: This retrospective analysis involved 166 patients. Demographic, clinical, and laboratory data were collected. AGR and the PNI were calculated as AGR = albumin/(total serum protein - albumin) and PNI = albumin (g/L) + 5 × total lymphocyte count (10(9)/L)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28223016/lymph-node-involvement-predicts-poor-prognosis-in-primary-tongue-adenoid-cystic-carcinoma-a-preliminary-study-of-54-cases
#19
Nannan Han, Huishan Ong, Zhihui Liu, Min Ruan, Wenjun Yang, Chenping Zhang
PURPOSE: Primary tongue adenoid cystic carcinoma (ACC) is extremely rare. The relationship between the patient's prognosis and the tumor's clinicopathological characteristics is uncertain. The aim of this study was to identify the prognostic factors and analyze the overall outcomes for patients with tongue ACC. PATIENTS AND METHODS: A retrospective analysis of the medical records of patients diagnosed with primary tongue ACC between 1998 and 2008 was conducted. The study comprised 54 patients, with a median age of 53...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28219213/-clinical-application-value-of-prognostic-nutritional-index-for-predicting-survival-in-patients-with-advanced-non-small-cell-lung-cancer
#20
W J Xu, Y M Kang, L Zhou, F F Chen, Y H Song, C Q Zhang
Objective: To explore the clinical application value of prognostic nutritional index(PNI) for predicting overall survival(OS) in patients with advanced non-small cell lung cancer (NSCLC). Methods: 123 patients with histologically confirmed non-small cell lung cancer were enrolled in this study, and their clinical and laboratory data were reviewed. The PNI was calculated as 10×serum albumin value+ 5×total lymphocyte countin peripheral blood.Univariate and multivariate analyses were used to identify the potential prognostic factors for advanced NSCLC...
February 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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