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management cirrosis

Su Jeong Lee, Hanvit Cha, Hyunjin Kim, Jin Hyup Lee, Jeen-Woo Park
Nonalcoholic fatty liver disease (NAFLD) has a high prevalence in the general population and can evolve into nonalcoholic steatohepatosis (NASH), cirrhosis, and complications such as liver failure and hepatocellular carcinoma. Recently, we reported that mitochondrial NADP+ -dependent isocitrate dehydrogenase, encoded by the IDH2, plays an important role in the regulation of redox balance and oxidative stress levels, which are tightly associated with intermediary metabolism and energy production. In the present study, we showed that in mice targeted disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38/cJun NH2-terminal kinase (JNK) and p53, presumably induced by the elevation of mitochondrial reactive oxygen species (ROS), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21) and the inhibition of NFκB signaling pathways...
April 2017: Free Radical Research
Vicens Diaz-Brito, Helder Cardoso, António Sarmento
Cirrhosis is the terminal phase of hepatic fibrosis, that leads to impaired hepatic function and blood flow. Liver cirrhosis is the final stage of many hepatic diseases characterized by chronic cellular destruction. The complications of liver cirrosis are the result of the hepatocellular lesion and portal hypertension. The most frequent complications are ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, gastroesophageal varices, portal hypertensive gastropathy, hypersplenism, hepatocellular carcinoma, methabolic disorders, hepatorenal syndrome and hepatopulmonary syndrome...
March 2008: Acta Médica Portuguesa
V A Osina, T N Kuz'mina
The present article gives evidence-based recommendations for the indication, application and type of formula of enteral nutrition (EN) (oral nutrition supplements (ONS) or tube feeding (TF)) in patients with Crohn's disease (CD), ulcerative colitis (UC), short bowel syndrome (SBS), acute and chronic pancreatitis, alcoholic steatogepatitis and cirrosis. ONS and/or TF in addition to normal food is indicates in undernourished patients with CD or UC to improve nutritional status. In active CD EN is the first line therapy in children and should be used as sole therapy in adults mainly when treatment with corticosteroids is not feasible...
2007: Experimental & Clinical Gastroenterology
M Coltorti, C Del Vecchio-Blanco, N Caporaso, C Gallo, L Castellano
A cross-sectional multicentric study was carried out over a six-month period as part of the "Progetto Nazionale Cirrosi Epatica", in order to update information about: a) the prevalence of different aetiologic factors and various nosological varieties of cirrhosis in Italy, as well as its presenting modalities; b) the currently used approach either to the diagnosis or the treatment of complications of cirrhosis; c) the impact of liver cirrhosis on medical care in terms of number of hospitalizations and length of hospital stay, instrumental procedures and management, and d) the size of patient's population referred to the participating centers, in order to help design further studies...
January 1991: Italian Journal of Gastroenterology
R Passariello, P Rossi, G Simonetti, A Ciolina, M Crecco
The hemorrage following gastro-esophageal varices cause a high degree of mortality. Personal experience is presented consisting in 15 patients suffering from cirrosis with inoperable hemorrages. These patients underwent transhepatic emergency obliteration of the varices. The hemorrage stopped in 10 patients, 6 of whom later on underwent surgical treatment with porto-systemical anastomosis. In 5 patients the hemorrage reappeared at various intervals from the procedure. Owing to the possible recanalization of the obliterated varices the procedure should be considered essentially as a preoperative management...
January 1979: La Radiologia Medica
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