Yu Chen, Yu Guo, Han Wu, Yi-Jie Tang, Suren Rao Sooranna, Li Zhang, Ting Chen, Xi-Yuan Xie, Liang-Cheng Qiu, Xiao-Dan Wu
IMPORTANCE: Postpartum depression (PPD) is one of the most common mental health conditions during the perinatal and postpartum periods, which can have adverse effects on both mother and infant. OBJECTIVE: To investigate the efficacy of perioperative adjunctive esketamine administration after cesarean deliveries in the prevention of PPD. DESIGN, SETTING, AND PARTICIPANTS: A single-center, double-blind, placebo-controlled, randomized clinical trial was conducted from January 1, 2022, to January 1, 2023, at Fujian Provincial Hospital among 298 women aged 18 to 40 years, with an American Society of Anesthesiologists grade I to III classification and singleton full-term pregnancies who were scheduled for elective cesarean deliveries...
March 4, 2024: JAMA Network Open