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MRI focal cortical dysplasia

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https://www.readbyqxmd.com/read/29679388/somatic-slc35a2-variants-in-the-brain-are-associated-with-intractable-neocortical-epilepsy
#1
Melodie R Winawer, Nicole G Griffin, Jorge Samanamud, Evan H Baugh, Dinesh Rathakrishnan, Senthilmurugan Ramalingam, David Zagzag, Catherine A Schevon, Patricia Dugan, Manu Hegde, Sameer A Sheth, Guy M McKhann, Werner K Doyle, Gerald A Grant, Brenda E Porter, Mohamad A Mikati, Carrie R Muh, Colin D Malone, Ann Marie R Bergin, Jurriaan M Peters, Danielle K McBrian, Alison M Pack, Cigdem I Akman, Christopher M LaCoursiere, Katherine M Keever, Joseph R Madsen, Edward Yang, Hart G W Lidov, Catherine Shain, Andrew S Allen, Peter Canoll, Peter B Crino, Annapurna H Poduri, Erin L Heinzen
OBJECTIVE Somatic variants are a recognized cause of epilepsy-associated focal malformations of cortical development (MCD). We hypothesized that somatic variants may underlie a wider range of focal epilepsy, including non-lesional focal epilepsy (NLFE). Through genetic analysis of brain tissue, we evaluated the role of somatic variation in focal epilepsy with and without MCD. METHODS We identified somatic variants through high-depth exome and ultra-high-depth candidate gene sequencing of DNA from epilepsy surgery specimens and leukocytes from 18 individuals with NLFE and 38 with focal MCD...
April 20, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29649770/advanced-dynamic-statistical-parametric-mapping-with-meg-in-localizing-epileptogenicity-of-the-bottom-of-sulcus-dysplasia
#2
Midori Nakajima, Simeon Wong, Elysa Widjaja, Shiro Baba, Tohru Okanishi, Lynne Takada, Yosuke Sato, Hiroki Iwata, Maya Sogabe, Hikaru Morooka, Robyn Whitney, Yuki Ueda, Tomoshiro Ito, Kazuyori Yagyu, Ayako Ochi, O Carter Snead, James T Rutka, James M Drake, Sam Doesburg, Fumiya Takeuchi, Hideaki Shiraishi, Hiroshi Otsubo
OBJECTIVE: To investigate whether advanced dynamic statistical parametric mapping (AdSPM) using magnetoencephalography (MEG) can better localize focal cortical dysplasia at bottom of sulcus (FCDB). METHODS: We analyzed 15 children with diagnosis of FCDB in surgical specimen and 3 T MRI by using MEG. Using AdSPM, we analyzed a ±50 ms epoch relative to each single moving dipole (SMD) and applied summation technique to estimate the source activity. The most active area in AdSPM was defined as the location of AdSPM spike source...
March 30, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29618099/surgical-treatment-of-extratemporal-epilepsy-results-and-prognostic-factors
#3
Daniel Delev, Bernhard Oehl, Bernhard J Steinhoff, Julia Nakagawa, Christian Scheiwe, Andreas Schulze-Bonhage, Josef Zentner
BACKGROUND: Surgery is a widely accepted option for the treatment of pharmacoresistant epilepsies of extratemporal origin. OBJECTIVE: To analyze clinical and epileptological results and to provide prognostic factors influencing seizure outcome. METHODS: This retrospective single-center study comprises a consecutive series of 383 patients, most of whom had an identifiable lesion on MRI, who underwent resective surgery for extratemporal epilepsy...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29594410/-18-f-fdg-pet-in-drug-resistant-epilepsy-due-to-focal-cortical-dysplasia-type-2-additional-value-of-electroclinical-data-and-coregistration-with-mri
#4
Serge Desarnaud, Charles Mellerio, Franck Semah, Agathe Laurent, Elisabeth Landre, Bertrand Devaux, Catherine Chiron, Vincent Lebon, Francine Chassoux
PURPOSE: To assess the localizing value of18 F-FDG PET in patients operated on for drug-resistant epilepsy due to focal cortical dysplasia type 2 (FCD2 ). METHODS: We analysed18 F-FDG PET scans from 103 consecutive patients (52 males, 7-65 years old) with histologically proven FCD2 . PET and MRI data were first reviewed by visual analysis blinded to clinical information and FCD2 location. The additional value of electroclinical data and PET/MRI coregistration was assessed by comparison with pathological results and surgical outcomes...
March 29, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29588945/seven-tesla-mri-improves-detection-of-focal-cortical-dysplasia-in-patients-with-refractory-focal-epilepsy
#5
Tim J Veersema, Cyrille H Ferrier, Pieter van Eijsden, Peter H Gosselaar, Eleonora Aronica, Fredy Visser, Jaco M Zwanenburg, Gerard A P de Kort, Jeroen Hendrikse, Peter R Luijten, Kees P J Braun
Objective: The aim of this study is to determine whether the use of 7 tesla (T) MRI in clinical practice leads to higher detection rates of focal cortical dysplasias in possible candidates for epilepsy surgery. Methods: In our center patients are referred for 7 T MRI if lesional focal epilepsy is suspected, but no abnormalities are detected at one or more previous, sufficient-quality lower-field MRI scans, acquired with a dedicated epilepsy protocol, or when concealed pathology is suspected in combination with MR-visible mesiotemporal sclerosis-dual pathology...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29554575/interictal-regional-paroxysmal-fast-activity-on-scalp-eeg-is-common-in-patients-with-underlying-gliosis
#6
Gopal Krishna Dash, Chaturbhuj Rathore, Malcolm K Jeyaraj, Pandurang Wattamwar, Sankara P Sarma, Kurupath Radhakrishnan
OBJECTIVE: Interictal regional paroxysmal fast activity (RPFA) on scalp EEG is common in patients with focal cortical dysplasia (FCD). Little data exists regarding the presence of RPFA in other etiologies. METHODS: We studied the association between RPFA and etiology on MRI in patients with drug resistant focal epilepsy undergoing presurgical evaluation in 2011. RPFA was defined as ≥3 consecutive spikes with a frequency of ≥10 Hz lasting ≥300 ms but <4 s...
February 27, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29550061/lesion-focused-radiofrequency-thermocoagulation-of-bottom-of-sulcus-focal-cortical-dysplasia-type-iib-conceptional-considerations-with-regard-to-the-epileptogenic-zone
#7
Jörg Wellmer
Small bottom-of-sulcus focal cortical dysplasias (BOS-FCD) type IIb are intrinsically epileptogenic lesions often responsible for pharmacoresistant epilepsy. They are increasingly well demarcated in vivo from surrounding cortex and white matter by 3 T magnetic resonance imaging (MRI). These facts and frequent seizure freedom after just narrow resections allow questioning the classical concept of epilepsy surgery in which the epileptogenic lesion is generally considered only one part of the epileptogenic zone and the resection volume categorically has to exceed lesion limits...
February 19, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29541057/small-lesion-size-is-associated-with-sleep-related-epilepsy-in-focal-cortical-dysplasia-type-ii
#8
Bo Jin, Wenhan Hu, Linmei Ye, Balu Krishnan, Thandar Aung, Stephen E Jones, Imad M Najm, Andreas V Alexopoulos, Kai Zhang, Junming Zhu, Jianguo Zhang, Meiping Ding, Zhong Chen, Shuang Wang, Zhong Irene Wang
Objective: To investigate the neuroimaging and clinical features associated with sleep-related epilepsy (SRE) in patients with focal cortical dysplasia (FCD) type II. Methods: Patients with histopathologically proven FCD type II were included from three epilepsy centers. SRE was defined according to the video EEG findings and seizure history. Cortical surface reconstruction and volume calculation were performed using FreeSurfer. The lesions were manually delineated on T1 volumetric MRI using the ITK-SNAP software...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29510282/a-multimodal-approach-for-radical-excision-of-focal-cortical-dysplasia-by-combining-advanced-mri-data-to-intraoperative-ultrasound-electrocorticography-and-cortical-stimulation-a-preliminary-experience
#9
Giovanni Tringali, Beatrice Bono, Ivano Dones, Roberto Cordella, Giuseppe Didato, Flavio Villani, Francesco Prada
BACKGROUND: Type II focal cortical dysplasia is the most common malformation of cortical development associated with drug resistant epilepsy and susceptible to surgical resection. Although advanced imaging modalities are nowadays capable to detect the majority of such cortical disorders, it is still a challenge for the surgeon to visualize them intraoperatively. The lack of direct boundaries' identification between normal brain and subtle dysplastic tissue may explain poor results in terms of seizure-free patients compared to other forms of epilepsy...
March 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29445916/bottom-of-sulcus-focal-cortical-dysplasia-presenting-as-epilepsia-partialis-continua-multimodality-characterization-including-7t-mri
#10
Sarah A Kelley, Shenandoah Robinson, Nathan E Crone, Bruno P Soares
INTRODUCTION: Bottom-of-sulcus focal cortical dysplasias are an under recognized, surgically treatable cause of focal epilepsy. Resection can dramatically reduce the seizure burden for children with refractory epilepsy, or eliminate seizures altogether. MATERIAL AND METHODS: We report the case and present the results of multimodality evaluation of a 15-year-old young man who presented with long-standing partial epilepsy affecting his right leg, which over the years became refractory to therapy...
February 14, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29422363/histopathology-of-3-tesla-mri-negative-extratemporal-focal-epilepsies
#11
Evangelos Kogias, Dirk-Matthias Altenmüller, Jan-Helge Klingler, Barbara Schmeiser, Horst Urbach, Soroush Doostkam
BACKGROUND: Information about the histopathology in 3 Tesla MRI negative extratemporal epilepsies is relatively limited. Most common histopathological findings in earlier (mixed 1.5 or 3 Tesla) MRI-negative series are focal cortical dysplasia (FCD), gliosis or normal findings. These series mostly use the older Palmini criteria for classification and grading. We focus on histopathology of only 3 Tesla MRI-negative extratemporal epilepsies according to the current ILAE criteria and investigate potential correlation to seizure outcome 1 year postoperatively...
February 5, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29414526/morphometric-analysis-on-t1-weighted-mri-complements-visual-mri-review-in-focal-cortical-dysplasia
#12
Lily C Wong-Kisiel, Diego F Tovar Quiroga, Daniel L Kenney-Jung, Robert J Witte, Alexandra Santana-Almansa, Gregory A Worrell, Jeffrey Britton, Benjamin H Brinkmann
OBJECTIVE: Focal cortical dysplasia (FCD) is a common pathology in focal drug resistant epilepsy (DRE). Voxel based morphometric MRI analysis has been proposed as an adjunct to visual detection of FCD, which remains challenging given the subtle radiographic appearance of FCD. This study evaluates the diagnostic value of morphometric analysis program (MAP) in focal DRE with pathology-confirmed FCD. METHODS: Automated morphometric analysis program analysis generated z-score maps derived from T1 images, referenced to healthy adult or pediatric controls for each of 39 cases with pathology-confirmed FCD...
January 26, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29398181/utility-of-additional-dedicated-high-resolution-3t-mri-in-children-with-medically-refractory-focal-epilepsy
#13
Raheel Ahmed, Luc Rubinger, Cristina Go, James M Drake, James T Rutka, O Carter Snead, Elysa Widjaja
PURPOSE: In patients with medically refractory epilepsy and normal magnetic resonance imaging (MRI), high-resolution dedicated MRI may identify cryptic lesions. The aim of this study was to assess improvement in lesion detection and its impact on clinical management, using additional high-resolution dedicated 3T MRI in children with medically refractory epilepsy who had normal 3T epilepsy protocol MRI. MATERIALS AND METHODS: Children who had resective epilepsy surgery and suspected focal cortical dysplasia (FCD) or normal 3T epilepsy protocol MRI were included...
February 2, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29334038/robotic-assisted-and-image-guided-mri-compatible-stereoelectroencephalography
#14
Jeffery A Hall, Hui Ming Khoo
BACKGROUND: Stereoelectroencephalography has been in regular use at the Montreal Neurological Institute since 1972. The technique has been in constant evolution to incorporate advances in materials, imaging, and robotics technology. MRI-compatible electrodes were introduced in 2007 and robotics in 2011. Here we report on the technique, safety, and advantages of our current method of stereoelectroencephalography implantation. METHODS: We retrospectively reviewed all patients who underwent stereoelectroencephalography by the senior author...
January 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29331846/functional-neuroimaging-in-rasmussen-syndrome
#15
Ichiro Kuki, Kazumi Matsuda, Yuko Kubota, Tetsuhiro Fukuyama, Yukitoshi Takahashi, Yushi Inoue, Haruo Shintaku
PURPOSE: For a diagnosis of Rasmussen syndrome (RS), clinical course together with electroencephalography (EEG) and magnetic resonance imaging (MRI) findings are considered important, but there are few reports on functional neuroimaging. This study investigated cerebral blood flow (CBF)-single photon emission computed tomography (SPECT), central benzodiazepine receptor (BZR)-SPECT, and fluorine-18 fluorodeoxy glucose-positron emission tomography (FDG-PET) in RS patients, and correlated neuroimaging results with MRI and pathological findings...
February 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29227798/histological-and-mri-markers-of-white-matter-damage-in-focal-epilepsy
#16
REVIEW
Francesco Deleo, Maria Thom, Luis Concha, Andrea Bernasconi, Boris C Bernhardt, Neda Bernasconi
Growing evidence highlights the importance of white matter in the pathogenesis of focal epilepsy. Ex vivo and post-mortem studies show pathological changes in epileptic patients in white matter myelination, axonal integrity, and cellular composition. Diffusion-weighted MRI and its analytical extensions, particularly diffusion tensor imaging (DTI), have been the most widely used technique to image the white matter in vivo for the last two decades, and have shown microstructural alterations in multiple tracts both in the vicinity and at distance from the epileptogenic focus...
February 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29219786/periinsular-anterior-quadrantotomy-technical-note
#17
Giulia Cossu, Sebastien Lebon, Margitta Seeck, Etienne Pralong, Mahmoud Messerer, Eliane Roulet-Perez, Roy Thomas Daniel
Refractory frontal lobe epilepsy has been traditionally treated through a frontal lobectomy. A disconnective technique may allow similar seizure outcomes while avoiding the complications associated with large brain resections. The aim of this study was to describe a new technique of selective disconnection of the frontal lobe that can be performed in cases of refractory epilepsy due to epileptogenic foci involving 1 frontal lobe (anterior to the motor cortex), with preservation of motor function. In addition to the description of the technique, an illustrative case is also presented...
February 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29197666/surgical-outcome-and-predictive-factors-of-epilepsy-surgery-in-pediatric-isolated-focal-cortical-dysplasia
#18
Sun Ah Choi, Soo Yeon Kim, Hyuna Kim, Woo Joong Kim, Hunmin Kim, Hee Hwang, Ji Eun Choi, Byung Chan Lim, Jong-Hee Chae, Sangjoon Chong, Ji Yeoun Lee, Ji Hoon Phi, Seung-Ki Kim, Kyu-Chang Wang, Ki Joong Kim
OBJECTIVE: Focal cortical dysplasia (FCD) is a common cause of medically intractable epilepsy in children. Epilepsy surgery has been a valuable treatment option to achieve seizure freedom in these intractable epilepsy patients. We aimed to present long-term surgical outcome, in relation to pathological severity, and to assess predictive factors of epilepsy surgery in pediatric isolated FCD. METHODS: We retrospectively analyzed the data of 58 children and adolescents, with FCD International League Against Epilepsy (ILAE) task force classification types I and II, who underwent resective epilepsy surgery and were followed for at least 2 years after surgery...
January 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29137921/intraoperative-definition-of-bottom-of-sulcus-dysplasia-using-intraoperative-ultrasound-and-single-depth-electrode-recording-a-technical-note
#19
Dorothea Miller, Patrick Carney, John S Archer, Gregory J Fitt, Graeme D Jackson, Kristian J Bulluss
Bottom of sulcus dysplasias (BOSDs) are localized focal cortical dysplasias (FCDs) centred on the bottom of a sulcus that can be highly epileptogenic, but difficult to delineate intraoperatively. We report on a patient with refractory epilepsy due to a BOSD, successfully resected with the aid of a multimodal surgical approach using neuronavigation based on MRI and PET, intraoperative ultrasound (iUS) and electrocorticography (ECoG) using depth electrodes. The lesion could be visualized on iUS showing an increase in echogenicity at the grey-white matter junction...
February 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29125946/a-stereo-eeg-study-in-a-patient-with-sleep-related-hypermotor-epilepsy-due-to-depdc5-mutation
#20
Lorenzo Ferri, Francesca Bisulli, Roberto Mai, Laura Licchetta, Chiara Leta, Lino Nobili, Barbara Mostacci, Tommaso Pippucci, Paolo Tinuper
PURPOSE: Dishevelled EGL-10 and pleckstrin domain-containing protein 5 (DEPDC5) mutations are found in a wide spectrum of focal epilepsies ranging from epilepsy caused by malformation of cortical development to non-lesional epilepsy, including sleep-related hypermotor epilepsy (SHE). A surgical approach has been anecdotally reported in patients with DEPDC5 mutations, but most of these cases had a lesional etiology. METHODS: We describe a stereo-EEG (SEEG) study in a patient with drug-resistant/non-lesional SHE...
December 2017: Seizure: the Journal of the British Epilepsy Association
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