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https://www.readbyqxmd.com/read/28344444/distribution-of-platelet-rich-plasma-after-ultrasound-guided-injection-for-chronic-elbow-tendinopathies
#1
Gi-Young Park, Dong Rak Kwon, Hee Kyung Cho, Jinyoung Park, Jung Hyun Park
Characteristics of the spreads of platelet-rich plasma (PRP) are not widely known despite commonly use. This study aims to evaluate whether PRP stays within the injected area by using ultrasonography, to improve understanding of the spreads of intratendinous injected PRP. Thirty-nine patients (15 males, 24 females; mean age, 49.3 years), who had symptoms on their elbows (> 6 months) and diagnosed as lateral (25 elbows) or medial (14 elbows) tendinopathies of elbow, were included. The severity of tendon pathology was assessed by ultrasonography as tear or no tear...
March 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28338698/thermally-driven-bubble-evolution-at-a-heater-wire-in-water-characterized-by-high-speed-transmission-electron-microscopy
#2
J R Vance, S J Dillon
This work investigates the early stage evolution of thermally nucleated microbubbles in water using in situ high-speed, 400 fps, transmission electron microscopy. A Pt wire Joule heater induced bubble nucleation and growth from air-saturated water at different levels of power. For all powers below Pt breakdown, the dissolved gas initiates bubble nucleation at the concave surface defects adjacent to the area of highest temperature. A combination of interfacial forces and stress relaxation drive rapid migration of the bubbles away from the nucleation site...
March 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28334688/preparation-of-poly-n-isopropylacrylamide-block-acrylic-acid-encapsulated-proteinaceous-microbubbles-for-delivery-of-doxorubicin
#3
Xiaochen Ma, Qingxia Liu
Inspired by theranostic technologies, we electrostatically loaded proteinaceous microbubbles (MBs) with a model drug, doxorubicin (Dox) to couple their utilizations in diagnostic imaging with drug loading. A temperature-sensitive polymer, poly(N-isopropylacrylamide-block-acrylic acid) (poly(NIPAM-b-AAc)) was used to encapsulate the Dox-loaded MBs to prevent premature release and to control the Dox release thermally. An LCST of 39°C, slightly higher than normal body temperatures, enables the release of Dox through a conformational change of the polymer shell upon moderate heating...
March 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28333964/optimizing-ultrasound-molecular-imaging-of-secreted-frizzled-related-protein-2-expression-in-angiosarcoma
#4
James K Tsuruta, Nicholas P Schaub, Juan D Rojas, Jason Streeter, Nancy Klauber-DeMore, Paul Dayton
Secreted frizzled related protein 2 (SFRP2) is a tumor endothelial marker expressed in angiosarcoma. Previously, we showed ultrasound molecular imaging with SFRP2-targeted contrast increased average video pixel intensity (VI) of angiosarcoma vessels by 2.2 ± 0.6 VI versus streptavidin contrast. We hypothesized that redesigning our contrast agents would increase imaging performance. Improved molecular imaging reagents were created by combining NeutrAvidin™-functionalized microbubbles with biotinylated SFRP2 or IgY control antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/28320656/targeting-effects-on-the-volume-of-the-focused-ultrasound-induced-blood-brain-barrier-opening-in-non-human-primates-in-vivo
#5
Maria Eleni Karakatsani, Gesthimani Samiotaki, Matthew Downs, Vincent Ferrera, Elisa Konofagou
Drug delivery to subcortical regions is susceptible to the blood-brain barrier (BBB) impeding the molecular exchange between the blood stream and the brain parenchyma. Focused ultrasound coupled with the administration of microbubbles has been proven to open the BBB locally, transiently and non-invasively both in rodents and in Non-Human-Primates (NHPs). The development of this disruption technique independent of MRI monitoring is of primordial importance yet restrained to the targeting optimization. The current paper establishes the linear relationship of the incidence angle with the volume of BBB opening (VBBB) and the Peak Negative Pressure (PNP) when sonicating the Caudate Nucleus and the Putamen region of five non-human-primates...
March 13, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28300033/-current-status-of-extracorporeal-shock-wave-lithotripsy-in-urinary-lithiasis
#6
Jose Gregorio Pereira-Arias, Mikel Gamarra-Quintanilla, Luis Felipe Urdaneta-Salegui, Jorge Alberto Mora-Christian, Andrea Sánchez-Vazquez, Ander Astobieta-Odriozola, Gaspar Ibarluzea-González
Over the last decade, urinary lithiasis' prevalence has dramatically increased due to diet and lifestyle changes, growing 10.6% and 7.1% in men and women respectively. Extracorporeal shock wave lithotripsy has lost relevance in current practice due to endoscopic device development and unpredictability of results. Instrument miniaturization is leading to an increase of the percutaneous approach of increasingly smaller stones, while most flexible ureteroscopes durability and digitalization has allowed urologists to address larger stones...
March 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28299722/a-versatile-method-for-the-preparation-of-particle-loaded-microbubbles-for-multimodality-imaging-and-targeted-drug-delivery
#7
Joshua Owen, Calum Crake, Jeong Yu Lee, Dario Carugo, Estelle Beguin, Alexandre A Khrapitchev, Richard J Browning, Nicola Sibson, Eleanor Stride
Microbubbles are currently in clinical use as ultrasound contrast agents and under active investigation as mediators of ultrasound therapy. To improve the theranostic potential of microbubbles, nanoparticles can be attached to the bubble shell for imaging, targeting and/or enhancement of acoustic response. Existing methods for fabricating particle-loaded bubbles, however, require the use of polymers, oil layers or chemical reactions for particle incorporation; embed/attach the particles that can reduce echogenicity; impair biocompatibility; and/or involve multiple processing steps...
March 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28291391/ultrasound-molecular-imaging-with-br55-in-patients-with-breast-and-ovarian-lesions-first-in-human-results
#8
Jürgen K Willmann, Lorenzo Bonomo, Antonia Carla Testa, Pierluigi Rinaldi, Guido Rindi, Keerthi S Valluru, Gianluigi Petrone, Maurizio Martini, Amelie M Lutz, Sanjiv S Gambhir
Purpose We performed a first-in-human clinical trial on ultrasound molecular imaging (USMI) in patients with breast and ovarian lesions using a clinical-grade contrast agent (kinase insert domain receptor [KDR] -targeted contrast microbubble [MBKDR]) that is targeted at the KDR, one of the key regulators of neoangiogenesis in cancer. The aim of this study was to assess whether USMI using MBKDR is safe and allows assessment of KDR expression using immunohistochemistry (IHC) as the gold standard. Methods Twenty-four women (age 48 to 79 years) with focal ovarian lesions and 21 women (age 34 to 66 years) with focal breast lesions were injected intravenously with MBKDR (0...
March 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28290184/ultrasound-contrast-enhanced-study-as-an-imaging-biomarker-for-anti-cancer-drug-treatment-preliminary-study-with-paclitaxel-in-a-xenograft-mouse-tumor-model-secondary-publication
#9
Hak Jong Lee, Sung Il Hwang, Jonghoe Byun, Hoon Young Kong, Hyun Sook Jung, Mira Kang
Purpose: The purpose of this study was to assess tumor angiogenesis using contrast-enhanced ultrasonography (CEUS) of human prostate cancer cells (PC3) that were implanted in mice before and after paclitaxel injection. Methods: Twelve mice were injected with human prostate cancer cells (PC3). The mice were grouped into two groups; one was the paclitaxel-treated group (n=6) and the other was the control group (n=6). Before administering paclitaxel into the peritoneal cavity, baseline CEUS was performed after the administration of 500 μL (1×108 microbubbles) of contrast agent...
February 14, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28290183/synthesis-of-ultrasound-contrast-agents-characteristics-and-size-distribution-analysis-secondary-publication
#10
Hak Jong Lee, Tae-Jong Yoon, Young Il Yoon
Purpose: The purpose of this study was to establish a method for ultrasound (US) contrast agent synthesis and to evaluate the characteristics of the synthesized US contrast agent. Methods: A US contrast agent, composed of liposome and sulfur hexafluoride (SF6), was synthesized by dissolving 21 μmol 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC, C40H80NO8P), 9 μmol cholesterol, and 1.9 μmol of dihexadecylphosphate (DCP, [CH3(CH2)15O]2P(O)OH) in chloroform...
February 14, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28288279/robust-whispering-gallery-mode-microbubble-lasers-from-colloidal-quantum-dots
#11
Yue Wang, Van Duong Ta, Kheng Swee Leck, Beng Hau Tan, Zeng Wang, Tingchao He, Claus-Dieter Ohl, Hilmi Volkan Demir, Handong Sun
Microlasers hold great promise for the development of photonics and optoelectronics. Among the discovered optical gain materials, colloidal quantum dots (CQDs) have been recognized as the most appealing candidate due to the facile emission tunability and solution processibility. However, to date, it is still challenging to develop CQD-based microlasers with low cost yet high performance. Moreover, the poor long-term stability of CQDs remains to be the most critical issue, which may block their laser aspirations...
March 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28287967/vibrational-responses-of-bound-and-non-bound-targeted-lipid-coated-single-microbubbles
#12
Tom van Rooij, Ines Beekers, Kirby R Lattwein, Ton van der Steen, Nico de Jong, Klazina Kooiman
One of the main challenges for ultrasound molecular imaging is acoustically distinguishing non-bound microbubbles from those bound to their molecular target. In this in vitro study, we compared two types of in-house produced targeted lipidcoated microbubbles, either consisting of DPPC or DSPC lipid as the main lipid, using the Brandaris 128 ultra-high-speed camera to determine vibrational response differences between bound and non-bound biotinylated microbubbles. In contrast to previous studies that studied vibrational differences upon binding, we used a covalently bound model biomarker (i...
March 7, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28283327/pharmacokinetics-of-perfluorobutane-after-intra-venous-bolus-injection-of-sonazoid-in-healthy-chinese-volunteers
#13
Pengfei Li, Susan Hoppmann, Ping Du, Huiling Li, Paul M Evans, Siver A Moestue, Weiyue Yu, Fang Dong, Hongchuan Liu, Lihong Liu
Sonazoid is an ultrasound contrast agent based on microbubbles (MB) containing perfluorobutane (PFB) gas. Sonazoid is approved in Japan, Korea and Norway for contrast-enhanced ultrasonography of focal liver lesions and focal breast lesions (Japan only). The objective of this study was to determine the pharmacokinetics (PKs) and safety of Sonazoid in Chinese healthy volunteers (HVs) and to evaluate the potential for ethnic differences in PKs between Chinese and Caucasian HVs. Sonazoid was administered as an intra-venous bolus injection at the clinical dose of 0...
March 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28280455/increasing-of-blood-brain-tumor-barrier-permeability-through-transcellular-and-paracellular-pathways-by-microbubble-enhanced-diagnostic-ultrasound-in-a-c6-glioma-model
#14
Jinlong Zhang, Heng Liu, Xuesong Du, Yu Guo, Xiao Chen, Shunan Wang, Jingqin Fang, Peng Cao, Bo Zhang, Zheng Liu, Weiguo Zhang
Most of the anticancer agents cannot be efficiently delivered into the brain tumor because of the existence of blood-brain tumor barrier (BTB). The objective of this study was to explore the effect of microbubble-enhanced diagnostic ultrasound (MEUS) on the BTB permeability and the possible mechanism. Glioma-bearing rats were randomized into three groups as follows: the microbubble-enhanced continued diagnostic ultrasound (MECUS) group; the microbubble-enhanced intermittent diagnostic ultrasound (MEIUS) group and the control group...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28279799/pbca-based-polymeric-microbubbles-for-molecular-imaging-and-drug-delivery
#15
Patrick Koczera, Lia Appold, Yang Shi, Mengjiao Liu, Anshuman Dasgupta, Vertika Pathak, Tarun Ojha, Stanley Fokong, Zhuojun Wu, Marc van Zandvoort, Olga Iranzo, Alexander Kuehne, Andrij Pich, Fabian Kiessling, Twan Lammers
Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. We describe different types of targeted and drug-loaded poly(n-butyl cyanoacrylate) (PBCA) MB, and demonstrate their suitability for multiple biomedical applications, including molecular US imaging and US-mediated drug delivery. Molecular imaging of angiogenic tumor blood vessels and inflamed atherosclerotic endothelium is performed by modifying the surface of PBCA MB with peptides and antibodies recognizing E-selectin and VCAM-1...
March 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28273102/age-related-differences-in-skeletal-muscle-microvascular-response-to-exercise-as-detected-by-contrast-enhanced-ultrasound-ceus
#16
Wulf Hildebrandt, Hans Schwarzbach, Anita Pardun, Lena Hannemann, Björn Bogs, Alexander M König, Andreas H Mahnken, Olaf Hildebrandt, Ulrich Koehler, Ralf Kinscherf
BACKGROUND: Aging involves reductions in exercise total limb blood flow and exercise capacity. We hypothesized that this may involve early age-related impairments of skeletal muscle microvascular responsiveness as previously reported for insulin but not for exercise stimuli in humans. METHODS: Using an isometric exercise model, we studied the effect of age on contrast-enhanced ultrasound (CEUS) parameters, i.e. microvascular blood volume (MBV), flow velocity (MFV) and blood flow (MBF) calculated from replenishment of Sonovue contrast-agent microbubbles after their destruction...
2017: PloS One
https://www.readbyqxmd.com/read/28268995/low-frequency-ultrasound-radiosensitization-and-therapy-response-monitoring-of-tumors-an-in-vivo-study
#17
Ali Sadeghi-Naini, Martin Stanisz, Hadi Tadayyon, Jaswinder Taank, Gregory J Czarnota
A new framework has been introduced in this paper for tumor radiosensitization and therapy response monitoring using low-frequency ultrasound. Human fibrosarcoma xenografts grown in severe combined immunodeficiency (SCID) mice (n = 108) were treated using ultrasound-stimulated microbubbles at various concentration and exposed to different doses of radiation. Low-frequency ultrasound radiofrequency (RF) data were acquired from tumors prior to and at different times after treatment. Quantitative ultrasound (QUS) techniques were applied to generate spectral parametric maps of tumors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267700/ultrasonography-for-noninvasive-assessment-of-portal-hypertension
#18
REVIEW
Hitoshi Maruyama, Osamu Yokosuka
Portal hypertension is a major pathophysiology in patients with cirrhosis. Portal pressure is the gold standard to evaluate the severity of portal hypertension, and radiological intervention is the only procedure for pressure measurement. Ultrasound (US) is a simple and noninvasive imaging modality available worldwide. B-mode imaging allows broad applications for patients to detect and characterize chronic liver diseases and focal hepatic lesions. The Doppler technique offers real-time observation of blood flow with qualitative and quantitative assessments, and the application of microbubble-based contrast agents has improved the detectability of peripheral blood flow...
March 9, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28266925/an-iterative-fullwave-simulation-approach-to-multiple-scattering-in-media-with-randomly-distributed-microbubbles
#19
Aditya Joshi, Brooks Lindsey, Paul Dayton, Gianmarco Pinton, Marie Muller
- Ultrasound contrast agents (UCA), such as microbubbles, enhance the scattering properties of blood, which is otherwise hypoechoic. The multiple scattering interactions of the acoustic field with UCA's are poorly understood due to the complexity of the multiple scattering theories and the nonlinear microbubble response. The majority of bubble models describe the behavior of UCA's as single, isolated microbubbles suspended in infinite medium. Multiple scattering models such as the Independent Scattering Approximation can approximate phase velocity and attenuation for low scatterer volume fraction...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28263564/theranostic-multilayer-capsules-for-ultrasound-imaging-and-guided-drug-delivery
#20
Jun Chen, Sithira Ratnayaka, Aaron Alford, Veronika Kozlovskaya, Fei Liu, Bing Xue, Kenneth Hoyt, Eugenia Kharlampieva
Despite the accessibility of ultrasound, the clinical potential of ultrasound-active theranostic agents has not been fully realized because it requires combining sufficient imaging contrast, high encapsulation efficiency, and ultrasound-triggered release in one entity. We report on theranostic polymer microcapsules composed of hydrogen-bonded multilayers of tannic acid and poly(N-vinylpyrrolidone) that produce high imaging contrast and deliver the anticancer drug doxorubicin upon low-power diagnostic or high-power therapeutic ultrasound irradiation...
March 28, 2017: ACS Nano
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