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https://www.readbyqxmd.com/read/28917802/on-chip-microfluidic-generation-of-monodisperse-bubbles-for-liquid-interfacial-tension-measurement
#1
Chen Wang, Jing Cao, Yue Zhou, Xing-Hua Xia
A novel microfluidic method for measuring liquid interfacial tension using monodisperse microbubbles generated in situ has been proposed. Instead of bulky gas supply used in traditional microfluidic devices, microbubbles are efficiently generated via water electrolysis in the devices. Since the bubble formation frequency is related to the interfacial tension of liquids used, thus, precisely measuring the interfacial tension of liquids in microfluidics can be achieved. In addition, it is found that during the microbubble formation, the electrochemical potential fluctuates regularly at controlled electrolysis current, and the fluctuating period depends on the microbubble generation rate...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28912893/the-role-of-nitric-oxide-during-sonoreperfusion-of-microvascular-obstruction
#2
Francois T H Yu, Xucai Chen, Adam C Straub, John J Pacella
Rationale: Microembolization during PCI for acute myocardial infarction can cause microvascular obstruction (MVO). MVO severely limits the success of reperfusion therapies, is associated with additional myonecrosis, and is linked to worse prognosis, including death. We have shown, both in in vitro and in vivo models, that ultrasound (US) and microbubble (MB) therapy (termed "sonoreperfusion" or "SRP") is a theranostic approach that relieves MVO and restores perfusion, but the underlying mechanisms remain to be established...
2017: Theranostics
https://www.readbyqxmd.com/read/28900624/ultrasound-mediated-microbubbles-destruction-augmented-sonolysis-an-in-vitro-and-in-vivo-study
#3
Hai Cui, Qiong Zhu, Yunhua Gao, Hongmei Xia, Kaibin Tan, Ying He, Zheng Liu, Yali Xu
OBJECTIVE: This study was aimed at exploring ultrasound mediated microbubbles destruction (UMMD) assisted sonolysis in both the in vitro and in vivo clots. METHODS: Therapeutic ultrasound (TUS) and lipid microbubbles (MBs) were used in whole blood clots and divided into the control, TUS group, and TUS + MB group. Thrombolytic rates and microscopy were performed. Color Doppler flow imaging (CDFI) and angiography were performed to evaluate the recanalization rates and flow scores in femoral arterial thrombus (FAT) in rabbits...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28894889/influence-of-contrast-enhanced-ultrasound-administration-setups-on-microbubble-enhancement-a-focus-on-pediatric-applications
#4
Michael R Kramer, Nishi Bhagat, Susan J Back, Laura Poznick, Flemming Forsberg, Kassa Darge, John R Eisenbrey
BACKGROUND: In pediatrics, contrast-enhanced ultrasound offers high-quality imaging with an excellent safety profile. OBJECTIVE: To investigate the effects of varying intravenous administration setups on in vitro enhancement and concentration of two commercially available ultrasound contrast agents, taking into consideration potential pediatric applications. MATERIALS AND METHODS: We quantified in vitro enhancement using a flow phantom (ATS Laboratories, Bridgeport, CT) and Acuson S3000 ultrasound system (Siemens Healthineers, Mountain View, CA) with a 9L4 probe in Cadence pulse sequencing mode...
September 11, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28885211/postoperative-control-of-functional-muscle-flaps-for-facial-palsy-reconstruction-ultrasound-guided-tissue-monitoring-using-contrast-enhanced-ultrasound-ceus-and-ultrasound-elastography
#5
A Kehrer, V Mandlik, C Taeger, S Geis, L Prantl, E M Jung
BACKGROUND AND OBJECTIVES: Facial paralysis causes excruciating impairments including facial asymmetry, limited eye closure, oral incontinence and social dysfunction. Modern plastic surgical reconstructions render favorable results with well-perfused dynamic muscle flaps. Post-operative tissue monitoring is a critical determinant for success. Contrast-enhanced Ultrasound (CEUS) and elastography have proven superior properties to evaluate tissue perfusion in various organs. We evaluated their role for functional muscle flaps positioned at the sub-skin level in facial palsy patients...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28885204/quantitative-evaluation-of-real-time-maximum-liver-capacity-limax-and-time-intensity-curve-tic-analysis-in-ceus-based-microperfusion
#6
M Haimerl, K Brünn, S Poelsterl, L P Beyer, I Wiesinger, C Stroszczynski, E-M Jung, P Wiggermann
PURPOSE: To compare the diagnostic performance of real-time maximum liver capacity (LiMAx) with dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation. MATERIALS AND METHODS: 23 patients underwent liver function capacity (LiMAx) test and consecutive or previous CEUS examinations. A bolus injection of 1.4 ml sulfur hexafluoride microbubbles was administered for CEUS measurements (1-6 MHz) and quantitative perfusion analysis (TIC) was performed with an integrated perfusion software using stored cine-loops...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28873696/enhanced-antimicrobial-effect-of-ultrasound-by-the-food-colorant-erythrosin-b
#7
Luis J Bastarrachea, Martin Walsh, Steven P Wrenn, Rohan V Tikekar
The synergistic combination of the food colorant Erythrosin B (E-B, FD&C 3) (0, 25, and 50μM) and low-frequency ultrasound (20kHz, 0.86-0.90WmL(-1)) was evaluated against Listeria innocua. Although E-B was antibacterial by itself, the inactivation rate significantly increased in a concentration-dependent manner upon exposure to ultrasound and followed a sigmoidal behavior. The enhanced antimicrobial effect of E-B in the presence of ultrasound can be explained in part from a microbubble disappearance study in which it was confirmed that the presence of E-B enhances inertial cavitation, thereby enhancing the antimicrobial effect of ultrasound...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28872315/universal-equations-for-the-coalescence-probability-and-long-term-size-stability-of-phospholipid-coated-monodisperse-microbubbles-formed-by-flow-focusing
#8
Tim Segers, Detlef Lohse, Michel Versluis, Peter Frinking
Resonantly driven monodisperse phospholipid-coated microbubbles are expected to substantially increase the sensitivity and efficiency in contrast-enhanced ultrasound imaging and therapy. They can be produced in a microfluidic flow-focusing device but questions remain as to the role of the device geometry, the liquid and gas flow, and the phospholipid formulation on bubble stability. Here, we develop a model based on simple continuum mechanics equations that reveals the scaling of the coalescence probability with the key physical parameters...
September 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28869455/influence-of-ultrasound-microbubbles-on-kidney-oxygen-tension
#9
P Lamby, L Prantl, A Krüger-Genge, R P Franke, E M Jung, F Jung
Ultrasound contrast agents (USCA) allows the dynamic detection of blood flow of both the macro and microvasculature. An obvious prerequisite for USCAs is the unhindered passage of clinically relevant dose levels through the microcirculation especially of the lungue, where they have to pass capillaries with diameters of around 4 μm. While smaller microbubbles rapidly passed through the microcirculation along with the red blood cells, larger microbubbles, however, were observed to coalesce and interrupt the blood flow...
August 28, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28868906/therapeutic-application-of-contrast-ultrasound-in-st-elevation-myocardial-infarction-role-in-coronary-thrombosis-and-microvascular-obstruction
#10
Jeroen Slikkerveer, Lynda Jm Juffermans, Niels van Royen, Yolande Appelman, Thomas R Porter, Otto Kamp
In the past few decades, cardiac ultrasound has become a widely available, easy-to-use diagnostic tool in many scenarios in acute cardiac care. The introduction of microbubbles extended its diagnostic value. Not long thereafter, several investigators explored the therapeutic potential of contrast ultrasound on thrombus dissolution. Despite large improvements in therapeutic options, acute ST elevation myocardial infarction remains one of the main causes of mortality and morbidity in the western world. The therapeutic effect of contrast ultrasound on thrombus dissolution might prove to be a new, effective treatment strategy in this group of patients...
September 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28866490/hadamard-encoded-multi-pulses-for-contrast-enhanced-ultrasound-imaging
#11
Ping Gong, Pengfei Song, Shigao Chen
The development of contrast-enhanced ultrasound (CEUS) imaging offers great opportunities for new ultrasound clinical applications such as myocardial perfusion imaging and abdominal lesion characterization. In CEUS imaging, the contrast agents (i.e., microbubbles) are utilized to improve the contrast between blood and tissue based on their high nonlinearity under low ultrasound pressure. In this paper, we propose a new CEUS pulse sequence by combining Hadamard-encoded multi-pulses (HEM) with fundamental frequency bandpass filter (i...
August 30, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28858788/development-of-a-fluid-dynamic-model-for-quantitative-contrast-enhanced-ultrasound-imaging
#12
Baudouin Denis de Senneville, Anthony Novell, Chloe Arthuis, Vanda Mendes, Paul-Armand Dujardin, Frederic Patat, Ayache Bouakaz, Jean-Michel Escoffre, Franck Perrotin
Contrast-enhanced ultrasound (CEUS) is a noninvasive imaging technique extensively used for blood perfusion imaging of various organs. This modality is based on the acoustic detection of gas-filled microbubble contrast agents used as intravascular flow tracers. Recent efforts aim at quantifying parameters related to the enhancement in the vascular compartment using time-intensity curve (TIC), and at using these latter as indicators for several pathological conditions. However, this quantification is mainly hampered by two reasons: first, the quantification intrinsically solely relies on temporal intensity variation, the explicit spatial transport of the contrast agent being left out...
August 29, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28856858/enhancing-ablation-effects-of-a-microbubble-contrast-agent-on-high-intensity-focused-ultrasound-an-experimental-and-clinical-study
#13
C Cheng, Z Xiao, G Huang, L Zhang, J Bai
OBJECTIVE: To investigate the relationship between SonoVue ablation enhancement effects on high-intensity focused ultrasound (HIFU) and the concentration of SonoVue and timing of HIFU. DESIGN: Two randomised controlled trials. SETTING: An animal centre in a university and a gynaecological department in a university hospital in China. POPULATION OR SAMPLE: 63 rabbits and 143 patients with a solitary uterine fibroid...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28843620/the-combination-of-glycolytic-inhibitor-2-deoxyglucose-and-microbubbles-increases-the-effect-of-5-aminolevulinic-acid-sonodynamic-therapy-in-liver-cancer-cells
#14
Rui Xie, Tongying Xu, Jiuxin Zhu, Xiaoli Wei, Wenting Zhu, Longmin Li, Yufeng Wang, Yu Han, Jianhua Zhou, Yuxian Bai
Sonodynamic therapy (SDT) overcomes the shortcoming of photodynamic therapy in the treatment of cancer. Previous studies indicated that the glycolysis inhibitor 2-deoxyglucose (2-DG) potentiated photodynamic therapy induced tumor cell death and microbubbles (MBs) improved the SDT performance. We hypothesized that the combination of 2-DG and MBs will increase the effect of 5-aminolevulinic acid (ALA)-SDT in HepG2 liver cancer cells. When cells were treated with 5-min ALA-SDT and 2-mmol/L 2-DG, the cell survival rate decreased to 73...
August 23, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28840954/assessing-the-kinetics-of-microbubble-appearance-in-cirrhotic-patients-using-transthoracic-saline-contrast-enhanced-echocardiography
#15
Adriano R Tonelli, Tawfeq Naal, Wael Dakkak, Margaret M Park, Raed A Dweik, James K Stoller
BACKGROUND: The number of cardiac cycles that need to be reviewed by echocardiography before a significant intrapulmonary shunt can be excluded remains unclear. METHODS: We retrospectively identified patients with cirrhosis who underwent technetium-99 m-labeled macroaggregated albumin scanning. The kinetics of bubble appearance after the injection of agitated saline during transthoracic echocardiograms were assessed in these patients. RESULTS: For the 64 eligible patients, the mean ± SD age was 56 ± 9 years...
August 25, 2017: Echocardiography
https://www.readbyqxmd.com/read/28829309/microbubble-axial-localization-errors-in-ultrasound-super-resolution-imaging
#16
Kirsten Christensen-Jeffries, Sevan Harput, Jemma Brown, Peter N T Wells, Paul Aljabar, Chris Dunsby, Meng-Xing Tang, Robert J Eckersley
Acoustic super-resolution imaging has allowed visualization of microvascular structure and flow beyond the diffraction limit using standard clinical ultrasound systems through the localization of many spatially isolated microbubble signals. The determination of each microbubble position is typically performed by calculating the centroid, finding a local maximum, or finding the peak of a 2-D Gaussian function fit to the signal. However, the backscattered signal from a microbubble depends not only on diffraction characteristics of the waveform, but also on the microbubble behavior in the acoustic field...
August 17, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28829305/extended-lifetime-in-vivo-pulse-stimulated-ultrasound-imaging
#17
James Wang, Christopher V Barback, Casey N Ta, Joi Weeks, Natalie Gude, Robert F Mattrey, Sarah L Blair, William C Trogler, Hotaik Lee, Andrew C Kummel
An on-demand long-lived ultrasound contrast agent that can be activated with single pulse stimulated imaging (SPSI) has been developed using hard shell liquid perfluoropentane filled silica 500 nm nanoparticles for tumor ultrasound imaging. SPSI was tested on LnCAP prostate tumor models in mice; tumor localization was observed after intravenous (IV) injection of the contrast agent. Consistent with enhanced permeability and retention, the silica nanoparticles displayed an extended imaging lifetime of 3.3 ± 1 days (mean ± standard deviation)...
August 17, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28829304/using-microbubble-as-contrast-agent-for-high-energy-x-ray-in-line-phase-contrast-imaging-demonstration-and-comparison-study
#18
Di Wu, Molly Donovan Wong, Kai Yang, Aimin Yan, Yuhua Li, Laurie Fajardo, Bin Zheng, Xizeng Wu, Hong Liu
The ability of microbubbles to benefit the imaging quality of high-energy in-line phase contrast as compared with conventional low-energy contact mode radiography was investigated. The study was conducted by comparing in-line phase contrast imaging with conventional contact-mode projection imaging under the same dose delivered to a phantom. A custom designed phantom was employed to simulate a segment of human blood vessel injected with microbubble suspensions. The microbubbles were suspended in deionized water to obtain different volume concentrations...
August 21, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28819825/ceus-li-rads-algorithm-implementation-and-key-differences-from-ct-mri
#19
Stephanie R Wilson, Andrej Lyshchik, Fabio Piscaglia, David Cosgrove, Hyun-Jung Jang, Claude Sirlin, Christoph F Dietrich, Tae Kyoung Kim, Juergen K Willmann, Yuko Kono
Contrast-enhanced ultrasound (CEUS) is a specialized form of ultrasound (US) performed with an intravenous injection of microbubble contrast agents. It has been successfully used for a variety of applications including characterization of liver tumors. In April 2014, the American College of Radiology (ACR) convened a working group of international experts to develop ACR CEUS Liver Imaging Reporting and Data System (CEUS LI-RADS). An initial version of CEUS LI-RADS was published in August 2016. Although the CEUS LI-RADS concept and principles for liver lesion characterization, using dynamic contrast enhancement features, are similar to those for CT or MRI, there are significant differences between CT/MRI and CEUS LI-RADS...
August 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28819447/targeting-activated-platelets-a-unique-and-potentially-universal-approach-for-cancer-imaging
#20
May Lin Yap, James D McFadyen, Xiaowei Wang, Nicholas A Zia, Jan David Hohmann, Melanie Ziegler, Yu Yao, Alan Pham, Matthew Harris, Paul S Donnelly, P Mark Hogarth, Geoffrey A Pietersz, Bock Lim, Karlheinz Peter
Rationale The early detection of primary tumours and metastatic disease is vital for successful therapy and is contingent upon highly specific molecular markers and sensitive, non-invasive imaging techniques. We hypothesized that the accumulation of activated platelets within tumours is a general phenomenon and thus represents a novel means for the molecular imaging of cancer. Here we investigate a unique single chain antibody (scFv), which specifically targets activated platelets, as a novel biotechnological tool for molecular imaging of cancer...
2017: Theranostics
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