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https://www.readbyqxmd.com/read/28527200/contrast-enhanced-ultrasound-ceus-in-renal-imaging-at-an-interdisciplinary-ultrasound-centre-possibilities-of-dynamic-microvascularisation-and-perfusion
#1
Franz Josef Putz, Anna Erlmeier, Isabel Wiesinger, Niklas Verloh, Christian Stroszczynski, Bernhard Banas, Ernst Michael Jung
OBJECTIVE: To identify the indications for CEUS in renal imaging in an interdisciplinary ultrasound department. METHODS: 102 CEUS examinations of the kidney in 82 patients between September 2014 and July 2016 were analysed regarding the indication for ultrasound. CEUS was performed by one experienced sonographer agent after bolus injection of 1.0 up to 2.4 ml sulphur hexafluoride microbubbles using multifrequency probes with Contrast Harmonic imaging. RESULTS: CEUS of the kidney was performed in patients from 20 to 87 years...
May 19, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28522149/measuring-absolute-blood-perfusion-in-mice-using-dynamic-contrast-enhanced-ultrasound
#2
Abbas Shirinifard, Suresh Thiagarajan, Melissa D Johnson, Christopher Calabrese, András Sablauer
We investigated the feasibility of estimating absolute tissue blood perfusion using dynamic contrast-enhanced ultrasound (CEUS) imaging in mice. We developed a novel method of microbubble administration and a model-free approach to estimate absolute kidney perfusion, and explored the kidney as a reference organ to estimate absolute perfusion of a neuroblastoma tumor. We performed CEUS on the kidneys of CD1 nude mice using the VisualSonics VEVO 2100 imaging system. We estimated individual kidney blood perfusion using the burst-replenishment (BR) technique...
May 15, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28521780/ultrasound-and-microbubble-induced-release-from-intracellular-compartments
#3
Farah Hussein, Costin Antonescu, Raffi Karshafian
BACKGROUND: Ultrasound and microbubbles (USMB) have been shown to enhance the intracellular uptake of molecules, generally thought to occur as a result of sonoporation. The underlying mechanism associated with USMB-enhanced intracellular uptake such as membrane disruption and endocytosis may also be associated with USMB-induced release of cellular materials to the extracellular milieu. This study investigates USMB effects on the molecular release from cells through membrane-disruption and exocytosis...
May 18, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28515335/in-situ-bone-tissue-engineering-via-ultrasound-mediated-gene-delivery-to-endogenous-progenitor-cells-in-mini-pigs
#4
Maxim Bez, Dmitriy Sheyn, Wafa Tawackoli, Pablo Avalos, Galina Shapiro, Joseph C Giaconi, Xiaoyu Da, Shiran Ben David, Jayne Gavrity, Hani A Awad, Hyun W Bae, Eric J Ley, Thomas J Kremen, Zulma Gazit, Katherine W Ferrara, Gadi Pelled, Dan Gazit
More than 2 million bone-grafting procedures are performed each year using autografts or allografts. However, both options carry disadvantages, and there remains a clear medical need for the development of new therapies for massive bone loss and fracture nonunions. We hypothesized that localized ultrasound-mediated, microbubble-enhanced therapeutic gene delivery to endogenous stem cells would induce efficient bone regeneration and fracture repair. To test this hypothesis, we surgically created a critical-sized bone fracture in the tibiae of Yucatán mini-pigs, a clinically relevant large animal model...
May 17, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28511329/-therapeutic-effect-of-combined-use-of-fgf1-loaded-nano-liposomes-and-ultrasound-targeted-microbubble-destruction-technique-on-treating-rats-with-experimental-diabetic-cardiomyopathy
#5
M Zhang, Y Z Zhao, W C Ma, J L Xu, J L Wang, M J Chen, L Yu, Y N Chen
Objective: The therapeutic effect of acid fibroblast growth factor 1(FGF1) on rats with diabetic cardiomyopathy (DCM) was evaluated by using nano-liposomes combined with ultrasound-targeted microbubble destruction technique (UTMD). Methods: The FGF1-loaded nano-liposomes were prepared by water-in-water emulsion method combined with lyophilization technique.TypeⅠdiabetes model was induced by intraperitoneal injection of streptozotocin (STZ, 70 mg/kg) in 60 male SD rats.Sixteen weeks later, diabetic rats were randomly divided into: placebo group (saline treatment), FGF1 group, FGF1-loaded nano-liposomes group, and FGF1-loaded nano-liposomes plus UTMD group (n=15 each)...
May 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28511219/-innovative-ultrasound-contrast-enhanced-ultrasound-of-the-kidneys
#6
Konrad Stock, Herbert Kübler, Tobias Maurer, Daniel Weiss, Hans-Peter Weskott, Uwe Heemann
Ultrasound examination of the kidneys with grey-scale imaging and colour Doppler ultrasound is the most common renal imaging modality. A few years ago, contrast-enhanced ultrasound (CEUS) emerged as a non-invasive perfusion imaging modality to evaluate the renal vessels and microvascularisation. These contrast media contain intravenous microbubbles (sulfur hexafluoride), which have no deleterious effect on renal function. Being free of iodine, they also pose no risk for the thyroid gland. CEUS of the kidneys is mainly used for the evaluation of renal cysts and the analysis of renal lesions suspicious for malignancy...
April 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28507898/optically-and-acoustically-triggerable-sub-micron-phase-change-contrast-agents-for-enhanced-photoacoustic-and-ultrasound-imaging
#7
Shengtao Lin, Anant Shah, Javier Hernández-Gil, Antonio Stanziola, Bethany I Harriss, Terry O Matsunaga, Nicholas Long, Jeffrey Bamber, Meng-Xing Tang
We demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration...
June 2017: Photoacoustics
https://www.readbyqxmd.com/read/28504278/high-frequency-linear-rheology-of-hydrogels-probed-by-ultrasound-driven-microbubble-dynamics
#8
Akaki Jamburidze, Marco De Corato, Axel Huerre, Angelo Pommella, Valeria Garbin
Ultrasound-driven microbubble dynamics are central to biomedical applications, from diagnostic imaging to drug delivery and therapy. In therapeutic applications, the bubbles are typically embedded in tissue, and their dynamics are strongly affected by the viscoelastic properties of the soft solid medium. While the behaviour of bubbles in Newtonian fluids is well characterised, a fundamental understanding of the effect on ultrasound-driven bubble dynamics of a soft viscoelastic medium is still being developed...
May 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/28494960/laser-activated-polymeric-microcapsules-for-ultrasound-imaging-and-therapy-in%C3%A2-vitro-feasibility
#9
Guillaume Lajoinie, Tom van Rooij, Ilya Skachkov, Emilie Blazejewski, Gert Veldhuis, Nico de Jong, Klazina Kooiman, Michel Versluis
Polymeric microcapsules with a light-absorbing dye incorporated in their shell can generate vapor microbubbles that can be spatiotemporally controlled by pulsed laser irradiation. These contrast agents of 6-8 μm in diameter can circulate through the vasculature, offering possibilities for ultrasound (molecular) imaging and targeted therapies. Here, we study the impact of such vapor bubbles on human endothelial cells in terms of cell poration and cell viability to establish the imaging and therapeutic windows...
May 9, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28494801/spectral-imaging-toolbox-segmentation-hyperstack-reconstruction-and-batch-processing-of-spectral-images-for-the-determination-of-cell-and-model-membrane-lipid-order
#10
Miles Aron, Richard Browning, Dario Carugo, Erdinc Sezgin, Jorge Bernardino de la Serna, Christian Eggeling, Eleanor Stride
BACKGROUND: Spectral imaging with polarity-sensitive fluorescent probes enables the quantification of cell and model membrane physical properties, including local hydration, fluidity, and lateral lipid packing, usually characterized by the generalized polarization (GP) parameter. With the development of commercial microscopes equipped with spectral detectors, spectral imaging has become a convenient and powerful technique for measuring GP and other membrane properties. The existing tools for spectral image processing, however, are insufficient for processing the large data sets afforded by this technological advancement, and are unsuitable for processing images acquired with rapidly internalized fluorescent probes...
May 12, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28489536/dual-frequency-piezoelectric-endoscopic-transducer-for-imaging-vascular-invasion-in-pancreatic-cancer
#11
Brooks D Lindsey, Jinwook Kim, Paul A Dayton, Xiaoning Jiang
Cancers of the pancreas have the poorest prognosis among all cancers, as many tumors are not detected until surgery is no longer a viable option. Surgical viability is typically determined via endoscopic ultrasound imaging. However, many patients who may be eligible for resection are not offered surgery due to diagnostic challenges in determining vascular or lymphatic invasion. In this article, we describe the development of a dual-frequency piezoelectric transducer for rotational endoscopic imaging designed to transmit at 4 MHz and receive at 20 MHz in order to image microbubble-specific superharmonic signals...
May 8, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28489274/ultrasound-imaging-based-on-molecular-targeting-for-quantitative-evaluation-of-hepatic-ischemia-reperfusion-injury
#12
Chen Qiu, Tinghui Yin, Yingcai Zhang, Yufan Lian, Yujia You, Kun Wang, Rongqin Zheng, Xintao Shuai
The present study aimed to quantitatively diagnose and monitor the therapy response of hepatic ischemia reperfusion injury (IRI) with targeted ultrasound (US) imaging. Targeted microbubbles (MBs ) were fabricated, and the binding of ICAM-1 antibodies to MBs was observed. To establish a quantitative method based on targeted US imaging, contrast-enhanced ultrasound (CEUS) was applied on IRI rats. After andrographolide treatment, the IRI rats were subjected to the quantitative targeted US imaging for a therapeutic effect...
May 10, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28484729/erratum-breast-tumor-response-to-ultrasound-mediated-excitation-of-microbubbles-and-radiation-therapy-in-vivo
#13
Priscilla Lai, Christine Tarapacki, William T Tran, Ahmed El Kaffas, Justin Lee, Clinton Hupple, Sarah Iradji, Anoja Giles, Azza Al-Mahrouki, Gregory J Czarnota
[This corrects the article DOI: 10.18632/oncoscience.299.].
January 2017: Oncoscience
https://www.readbyqxmd.com/read/28484307/understanding-acoustic-cavitation-initiation-by-porous-nanoparticles-toward-nanoscale-agents-for-ultrasound-imaging-and-therapy
#14
Adem Yildirim, Rajarshi Chattaraj, Nicholas T Blum, Andrew P Goodwin
Ultrasound is widely applied in medical diagnosis and therapy due to its safety, high penetration depth, and low cost. In order to improve the contrast of sonographs and efficiency of the ultrasound therapy, echogenic gas bodies or droplets (with diameters from 200 nm to 10 µm) are often used, which are not very stable in the bloodstream and unable to penetrate into target tissues. Recently, it was demonstrated that nanobubbles stabilized by nanoparticles can nucleate ultrasound responsive microbubbles under reduced acoustic pressures, which is very promising for the development of nanoscale (<100 nm) ultrasound agents...
August 23, 2016: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/28479088/ultrasound-and-intra-clot-microbubbles-enhanced-catheter-directed-thrombolysis-in%C3%A2-vitro-and-in%C3%A2-vivo
#15
Shunji Gao, Qiong Zhu, MengJiao Guo, Yuan Gao, Xiaoxiao Dong, Zhong Chen, Zheng Liu, Feng Xie
Insufficient penetration of microbubbles (MBs) into the vessel-obstructing thrombi significantly reduces the effectiveness of ultrasound thrombolysis (UT). The widely performed catheter-directed therapy (CDT) makes it possible to increase the local concentration of MBs in the clot. In an occluded vessel with a bypass, treatment of fresh human whole blood clots with CDT-based UT (intra-clot injection of MBs and urokinase, with ultrasound exposure) resulted in a significantly higher percentage of weight loss (35...
May 4, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28473660/pegylated-plga-based-phase-shift-nanodroplets-combined-with-focused-ultrasound-for-blood-brain-barrier-opening-in-rats
#16
Xiang Zhang, Jiangang Hu, Guanjian Zhao, Ning Huang, Ying Tan, Li Pi, Qing Huang, Feng Wang, Zhigang Wang, Zhibiao Wang, Yuan Cheng
Previous studies have shown that focused ultrasound (FUS) combined with systematic administration of microbubbles (MBs) can open the blood brain barrier (BBB) locally, transiently and reversibly. However, because of the micro size diameters, MBs are restricted in the intravascular space and cannot extravasate into diseased sites through the opened BBB. In this study, we fabricated one kind of nanoscale droplets which consisted of encapsulated liquid perfluoropentane cores and poly (ethyleneglycol) - poly (lactide-co-glycolic acid) shells...
April 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472168/development-of-prostate-specific-membrane-antigen-targeted-ultrasound-microbubbles-using-bioorthogonal-chemistry
#17
Aimen Zlitni, Melissa Yin, Nancy Janzen, Samit Chatterjee, Ala Lisok, Kathleen L Gabrielson, Sridhar Nimmagadda, Martin G Pomper, F Stuart Foster, John F Valliant
Prostate specific membrane antigen (PSMA) targeted microbubbles (MBs) were developed using bioorthogonal chemistry. Streptavidin-labeled MBs were treated with a biotinylated tetrazine (MBTz) and targeted to PSMA expressing cells using trans-cyclooctene (TCO)-functionalized anti-PSMA antibodies (TCO-anti-PSMA). The extent of MB binding to PSMA positive cells for two different targeting strategies was determined using an in vitro flow chamber. The initial approach involved pretargeting, where TCO-anti-PSMA was first incubated with PSMA expressing cells and followed by MBTz, which subsequently showed a 2...
2017: PloS One
https://www.readbyqxmd.com/read/28464648/laser-driven-resonance-of-dye-doped-oil-coated-microbubbles-a-theoretical-and-numerical-study
#18
Guillaume Lajoinie, Erik Linnartz, Pieter Kruizinga, Nico de Jong, Eleanor Stride, Gijs van Soest, Michel Versluis
Microbubbles are used to enhance the contrast in ultrasound imaging. When coated with an optically absorbing material, these bubbles can also provide contrast in photoacoustic imaging. This multimodal aspect is of pronounced interest to the field of medical imaging. The aim of this paper is to provide a theoretical framework to describe the physical phenomena underlying the photoacoustic response. This article presents a model for a spherical gas microbubble suspended in an aqueous environment and coated with an oil layer containing an optically absorbing dye...
April 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28463190/improved-contrast-enhanced-power-doppler-using-a-coherence-based-estimator
#19
Charles Tremblay-Darveau, Avinoam Bar-Zion, R Williams, Paul Sheeran, Laurent Milot, Thanasis Loupas, Dan Adam, Matthew Bruce, Peter Burns
While plane-wave imaging can improve the performance of power Doppler by enabling much longer ensembles than systems using focused beams, the long-ensemble averaging of the zero-lag autocorrelation R(0) estimates does not directly decrease the mean noise level, but only decreases its variance. Spatial variation of the noise due to the time-gain compensation and the received beamforming aperture ultimately limits sensitivity. In this paper, we demonstrate that the performance of power Doppler imaging can be improved by leveraging the higher lags of the autocorrelation (e...
April 28, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28460221/fabrication-of-ultrasound-responsive-microbubbles-via-coaxial-electrohydrodynamic-atomization-for-triggered-release-of-tpa
#20
Wei-Cheng Yan, Qing Wei Chua, Xiu Jing Ong, Vijay Kumar Sharma, Yen Wah Tong, Chi-Hwa Wang
A single-step fabrication method, coaxial electrohydrodynamic atomization (CEHDA), was developed to synthesize drug-loaded microbubbles (MBs) for combination treatment of ischemic stroke. The bioactivity of therapeutic agent (tPA, tissue plasminogen activator) after preparation was evaluated, showing that CEHDA could be very promising method for producing MBs with therapeutic functions. The bubble performance and tPA release profiles were also examined by exposing the bubbles to 2MHz ultrasound of various intensities...
April 24, 2017: Journal of Colloid and Interface Science
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