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https://www.readbyqxmd.com/read/28642201/combination-of-coenzyme-q10-loaded-liposomes-with-ultrasound-targeted-microbubbles-destruction-utmd-for-early-theranostics-of-diabetic-nephropathy
#1
Ting Yue, He-Lin Xu, Pian-Pian Chen, Lei Zheng, Qun Huang, Wen-Shuang Sheng, Yuan-Di Zhuang, Li-Zhuo Jiao, Ting-Ting Chi, De-Li ZhuGe, Jin-Jin Liu, Ying-Zheng Zhao, Li Lan
Diabetic nephropathy (DN) is one of the most common and lethal microvascular complications of diabetes. This study aimed to explore whether coenzymeQ10 (CoQ10) as an antioxidant combined with ultrasound-targeted microbubble destruction (UTMD) could reverse the progress of early diabetic nephropathy (DN). CoQ10 has great potential to treat early DN. However, the clinical application of CoQ10 has been limited because of its low aqueous solubility and non-specific distribution. Therefore, CoQ10-loaded liposomes (CoQ10-lip) were prepared and combined with ultrasound microbubbles for the early theranostics of DN...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28642036/transcription-factor-decoy-technology-a-therapeutic-update
#2
REVIEW
Markus Hecker, Andreas H Wagner
Targeting transcription factors represents one possibility to interfere with a known activated regulatory pathway that promotes disease. Double-stranded transcription factor decoy (TFD) oligodeoxynucleotides (ODN) are therapeutic drug candidates, which are able to specifically target and neutralize key transcription factors involved in the pathogenesis of a given disease. These short double-stranded TFD molecules mimic the consensus DNA binding site of a specific transcription factor in the promoter region of its target genes...
June 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28634555/a-rare-case-of-pneumopericardium-in-the-setting-of-tuberculous-constrictive-pericarditis
#3
Lauro L Abrahan Iv, Stephanie Martha O Obillos, Jaime Alfonso M Aherrera, Jose Donato A Magno, Celia Catherine C Uy-Agbayani, Ulysses King G Gopez, Jobelle Joyce Anne R Baldonado
A 28-year-old Filipino male was admitted due to high-grade fevers and dyspnea on a background of chronic cough and weight loss. Due to clinical and echocardiographic signs of cardiac tamponade, emergency pericardiocentesis was performed on his first hospital day. Five days after, chest radiographs showed new pockets of radiolucency within the cardiac shadow, indicative of pneumopericardium. On repeat echo, air microbubbles admixed with loculated effusion were visualized in the anterior pericardial space. Constrictive physiology was also supported by a thickened pericardium, septal bounce, exaggerated respiratory variation in AV valve inflow, and IVC plethora...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28631766/-postural-effect-in-patients-with-patent-foramen-ovale-evaluation-of-right-to-left-shunt-with-transcranial-doppler-and-transthoracic-echocardiography-and-correlation-with-arterial-oxygen-saturation
#4
Stefano Lucreziotti, Chiara Debenedetti, Laura Massironi, Antonio Mantero, Fabiano Di Marco, Massimo Chessa, Stefano Carugo
BACKGROUND: Transcranial Doppler echocardiography and transthoracic echocardiography may detect with high accuracy right-to-left shunt (RLS) due to patent foramen ovale (PFO). However, a standardized diagnostic protocol has never been established. It has been suggested that standing or sitting positions may improve sensitivity of transcranial Doppler due to increased LRS in such positions. We aimed to test efficacy of the sitting position in addition to the supine position in the grading of RLS in patients with PFO...
June 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28625610/current-progress-in-antivascular-tumor-therapy
#5
REVIEW
Yi-Ju Ho, Tzu-Chia Wang, Ching-Hsiang Fan, Chih-Kuang Yeh
The tumor vasculature transports oxygen, nutrients and drugs for crucial roles in tumor therapy. Antivascular therapy directly targets existing tumor vessels to reduce blood perfusion and then inhibit tumor growth. Vascular disrupting agents and ultrasound-stimulated microbubble destruction use chemical toxicity and physical effect, respectively, to damage vascular endothelial cells for antivascular therapy. Moreover, antivascular therapy can break vessel wall barriers and change the tumor microenvironment to compensate for the limitations of conventional chemotherapy or radiotherapy...
June 15, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28625558/irregular-defects-in-hepatocellular-carcinomas-during-the-kupffer-phase-of-contrast-enhanced-ultrasonography-with-perfluorobutane-microbubbles-pathological-features-and-metastatic-recurrence-after-surgical-resection
#6
Junya Nuta, Naoki Shingaki, Yoshiyuki Ida, Ryo Shimizu, Shinya Hayami, Masaki Ueno, Kazuhiro Fukatsu, Masahiro Itonaga, Takeichi Yoshida, Yoshimasa Maeda, Kosaku Moribata, Hisanobu Deguchi, Takao Maekita, Mikitaka Iguchi, Jun Kato, Hiroki Yamaue, Hideyuki Tamai
The present study aimed to elucidate the association between post-vascular-phase (Kupffer-phase) images from contrast-enhanced ultrasonography (CEUS) with perfluorobutane microbubbles and metastatic recurrences after the resection of hepatocellular carcinoma (HCC). The study examined 73 patients with solitary HCC ≤5 cm in diameter who underwent CEUS before resection. HCC was defined as irregular type (including an irregular defect on Kupffer-phase images) or non-irregular type. Intrahepatic metastatic recurrence was defined as >3 intrahepatic recurrences...
June 15, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28621156/pilot-study-use-of-contrast-enhanced-ultrasonography-in-feline-renal-transplant-recipients
#7
Esther H Greenbarg, David A Jiménez, Lucas A Nell, Chad W Schmiedt
Objectives The study aims were to evaluate the feasibility of contrast-enhanced ultrasonography in feline renal transplant recipients in the post-transplantation period and to report findings in a case with presumptive delayed allograft ischemia. Methods Cats were imaged postoperatively using contrast harmonic ultrasonography after a bolus injection of a microbubble contrast medium. Time/mean pixel intensity curves were generated for cortical and medullary regions of interest in the renal allograft in each cat...
June 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28618348/ultrasound-sensitive-nanoparticle-aggregates-for-targeted-drug-delivery
#8
Anne-Laure Papa, Netanel Korin, Mathumai Kanapathipillai, Akiko Mammoto, Tadanori Mammoto, Amanda Jiang, Robert Mannix, Oktay Uzun, Christopher Johnson, Deen Bhatta, Garry Cuneo, Donald E Ingber
Here we describe injectable, ultrasound (US)-responsive, nanoparticle aggregates (NPAs) that disintegrate into slow-release, nanoscale, drug delivery systems, which can be targeted to selective sites by applying low-energy US locally. We show that, unlike microbubble based drug carriers which may suffer from stability problems, the properties of mechanical activated NPAs, composed of polymer nanoparticles, can be tuned by properly adjusting the polymer molecular weight, the size of the nanoparticle precursors as well as the percentage of excipient utilized to hold the NPA together...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28615645/intravascular-forward-looking-ultrasound-transducers-for-microbubble-mediated-sonothrombolysis
#9
Jinwook Kim, Brooks D Lindsey, Wei-Yi Chang, Xuming Dai, Joseph M Stavas, Paul A Dayton, Xiaoning Jiang
Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611257/isolated-intrapulmonary-vascular-dilatations-and-the-risk-of-developing-hepatopulmonary-syndrome-in-liver-transplant-candidates
#10
Manuel Mendizabal, David Goldberg, Federico Piñero, Diego Arufe, María José de la Fuente, Pablo Testa, Matías Coronel, Sergio Baratta, Luis Podestá, Michael Fallon, Marcelo Silva
BACKGROUND: The natural history of intrapulmonary vascular dilations (IPVD) and their impact on patient outcomes in the setting of portal hypertension has only been described in small series. AIMS: To assess the development of hepatopulmonary síndrome (HPS) in patients with isolated IPVD and to evaluate outcomes of IPVD and HPS among patients evaluated for liver transplantation (LT). MATERIAL AND METHODS: Data from a prospective cohort of patients evaluated for LT with standardized screening for HPS were analyzed...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611128/decreased-kcne2-expression-participates-in-the-development-of-cardiac-hypertrophy-by-regulation-of-calcineurin-nfat-nuclear-factor-of-activated-t-cells-and-mitogen-activated-protein-kinase-pathways
#11
Wenjuan Liu, Jianxin Deng, Wenwen Ding, Gang Wang, Yuanyuan Shen, Junmeng Zheng, Xiaoming Zhang, Yizhi Luo, Chifei Lv, Yonghui Wang, Liqing Chen, Dewen Yan, Ryan L Boudreau, Long-Sheng Song, Jie Liu
BACKGROUND: KCNE2 is a promiscuous auxiliary subunit of voltage-gated cation channels. A recent work demonstrated that KCNE2 regulates L-type Ca(2+) channels. Given the important roles of altered Ca(2+) signaling in structural and functional remodeling in diseased hearts, this study investigated whether KCNE2 participates in the development of pathological hypertrophy. METHODS AND RESULTS: We found that cardiac KCNE2 expression was significantly decreased in phenylephrine-induced cardiomyocyte hypertrophy in neonatal rat ventricular myocytes and in transverse aortic constriction-induced cardiac hypertrophy in mice, as well as in dilated cardiomyopathy in human...
June 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28610835/antibiofilm-effect-of-ultrasound-combined-with-microbubbles-against-staphylococcus-epidermidis-biofilm
#12
Ying Dong, Yaling Xu, Pan Li, Chuanqing Wang, Yun Cao, Jialin Yu
Biofilms are difficult to eradicate due to their resistance to antibiotics and host immune cells. Ultrasound microbubbles have emerged as a new treatment modality with the underlying mechanisms largely unknown. In this study, we exposed 24-h-old Staphylococcus epidermidis biofilms established in OptiCell™ chambers to ultrasound in combination with microbubbles, and investigated the activities of vancomycin and neutrophils against S. epidermidis biofilms after treatment. The antibiofilm mechanims of ultrasound microbubbles were explored in terms of bacterial permeability and biofilm-associated gene expression...
June 11, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28607323/ultrasound-guided-drug-delivery-in-cancer
#13
Sayan Mullick Chowdhury, Taehwa Lee, Jürgen K Willmann
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy...
May 1, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28603605/phase-behavior-of-mixed-lipid-monolayers-on-perfluorocarbon-nanoemulsions-and-its-effect-on-acoustic-contrast
#14
Rajarshi Chattaraj, Galen M Goldscheitter, Adem Yildirim, Andrew P Goodwin
Lipid-stabilized nanoemulsions containing a volatile liquid perfluorocarbon core have been studied as ultrasound contrast agents owing to their ability to transform into high-contrast microbubbles when subjected to high intensity focused ultrasound (HIFU). However, while there have been several studies on the effect of acoustic parameters on contrast, the effect of the droplet's stabilizing shell has not been studied as extensively. Inspired by previous studies showing lateral phase separation in microbubbles and vesicles, nanodroplets were formulated with a perfluorohexane core and a shell composed of varying amounts of saturated (DPPC) phospholipids, unsaturated (DOPC) phospholipids, and cholesterol, which were fractionated to obtain nanodroplets of mean diameter 300-400 nm and were stable over one week...
December 4, 2016: RSC Advances
https://www.readbyqxmd.com/read/28599556/acoustic-force-measurements-on-polymer-coated-microbubbles-in-a-microfluidic-device
#15
Gianluca Memoli, Christopher R Fury, Kate O Baxter, Pierre N Gélat, Philip H Jones
This work presents an acoustofluidic device for manipulating coated microbubbles, designed for the simultaneous use of optical and acoustical tweezers. A comprehensive characterization of the acoustic pressure in the device is presented, obtained by the synergic use of different techniques in the range of acoustic frequencies where visual observations showed aggregation of polymer-coated microbubbles. In absence of bubbles, the combined use of laser vibrometry and finite element modelling supported a non-invasive measurement of the acoustic pressure and an enhanced understanding of the system resonances...
May 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28598835/efficacy-of-contrast-enhanced-ultrasound-for-immediate-assessment-of-ablation-status-after-intraoperative-radiofrequency-ablation-of-hepatic-malignancies
#16
N Platz Batista da Silva, L P Beyer, M C Hottenrott, C Hackl, H J Schlitt, C Stroszczynski, P Wiggermann, E M Jung
AIM: To evaluate the Efficacy of intraoperative contrast enhanced ultrasound (Io-CEUS) for assessment of radiofrequency ablation (RFA) during liver tumor surgery. MATERIAL AND METHODS: Retrospective analyis was performed on 18 patients who underwent combined liver tumor surgery and RFA of 27 hepatic tumors between 02/2011 and 12/2016. Io-CEUS was performed by bolus injections of up to 10 ml sulphur hexaflourid microbubbles for diagnostic purposes. To guide the RFA up to 20 ml microbubbles were applied to monitor the procedure and assess the ablation status finally...
June 3, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28598141/evaluation-of-cerebral-perfusion-by-contrast-enhanced-ultrasound-at-low-mechanical-index-in-cerebral-ischemia-rat-model
#17
Xiaolei Wang, Bo Liu, Jiongou Liu, Aitong Sun, Yan Cui, Rui Xiao, Chunyang Li
BACKGROUND: No data is available for brain low mechanical index (low-MI) contrast-enhanced ultrasound (CEUS). This study aimed to assess low-MI CEUS for cerebral ischemia in rats. METHODS: Twenty adult Wistar rats were divided to the brain ischemia (n=12) and sham (n=8) groups. A Logiq E9 (GE; ML6-15 probe) was used. Bolus injection of SonoVue (Bracco) at 3.6 ml/kg was performed. Cerebral perfusion was evaluated using time to peak (TTP) and area under the curve (AUC) of time-intensity curves (TIC)...
June 9, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28595620/transcranial-pulsed-ultrasound-facilitates-brain-uptake-of-laronidase-in-enzyme-replacement-therapy-for-mucopolysaccharidosis-type-i-disease
#18
Yu-Hone Hsu, Ren-Shyan Liu, Win-Li Lin, Yeong-Seng Yuh, Shuan-Pei Lin, Tai-Tong Wong
BACKGROUND: Mucopolysaccharidosis type I (MPS I) is a debilitating hereditary disease characterized by alpha-L-iduronidase (IDUA) deficiency and consequent inability to degrade glycosaminoglycans. The pathological accumulation of glycosaminoglycans systemically results in severe mental retardation and multiple organ dysfunction. Enzyme replacement therapy with recombinant human alpha-L-iduronidase (rhIDU) improves the function of some organs but not neurological deficits owing to its exclusion from the brain by the blood-brain barrier (BBB)...
June 8, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28595164/imaging-and-analysis-of-individual-cavitation-microbubbles-around-dental-ultrasonic-scalers
#19
N Vyas, H Dehghani, R L Sammons, Q X Wang, D M Leppinen, A D Walmsley
Cavitation is a potentially effective and less damaging method of removing biofilm from biomaterial surfaces. The aim of this study is to characterise individual microbubbles around ultrasonic scaler tips using high speed imaging and image processing. This information will provide improved understanding on the disruption of dental biofilm and give insights into how the instruments can be optimised for ultrasonic cleaning. Individual cavitation microbubbles around ultrasonic scalers were analysed using high speed recordings up to a million frames per second with image processing of the bubble movement...
May 24, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28592999/contrast-enhanced-ultrasound-of-the-carotid-system-a-review-of-the-current-literature
#20
REVIEW
Vasileios Rafailidis, Afroditi Charitanti, Thomas Tegos, Evangelos Destanis, Ioannis Chryssogonidis
Carotid disease is a major current health problem accounting for a significant part of stroke patients. Ultrasound with colour Doppler and spectral analysis is the primary imaging technique used for screening and diagnostic evaluation of the extracranial part of carotid arteries offering identification and grading of carotid disease. However, inherent limitations of this technique include flow-related artefacts like Doppler angle dependence and aliasing artefact which may sometimes hinder complete assessment of a stenotic part of the vessel, potentially failing to address clinically significant differential diagnosis issues...
June 2017: Journal of Ultrasound
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