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https://www.readbyqxmd.com/read/27910051/ultrasound-targeted-microbubble-destruction-for-cardiac-gene-delivery
#1
Shuyuan Chen, Paul A Grayburn
Ultrasound targeted microbubble destruction (UTMD) is a novel technique that is used to deliver a gene or other bioactive substance to organs of living animals in a noninvasive manner. Plasmid DNA binding with cationic liposome into nanoparticles are assembled into the shell of microbubbles, which are circulated by intravenous injection. Intermittent bursts of ultrasound with low frequency and high mechanical index destroys the microbubbles and releases the nanoparticles into targeted organ to transfect local organ cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27908167/computer-aided-prognosis-for-cell-death-categorization-and-prediction-in-vivo-using-quantitative-ultrasound-and-machine-learning-techniques
#2
M J Gangeh, A Hashim, A Giles, L Sannachi, G J Czarnota
PURPOSE: At present, a one-size-fits-all approach is typically used for cancer therapy in patients. This is mainly because there is no current imaging-based clinical standard for the early assessment and monitoring of cancer treatment response. Here, the authors have developed, for the first time, a complete computer-aided-prognosis (CAP) system based on multiparametric quantitative ultrasound (QUS) spectroscopy methods in association with texture descriptors and advanced machine learning techniques...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908050/modeling-and-parametric-investigation-of-thick-encapsulated-microbubble-s-nonspherical-oscillations
#3
Ganesh Tamadapu, Dmitry Grishenkov, Anders Eriksson
Numerous studies have been carried out in the past few decades to investigate the radial oscillations of encapsulated microbubbles (MBs). Nonspherical oscillations also have gained attention, being unavoidable in actual applications of these bubbles. The present paper is intended to describe the nature of resonance trends of such spherical and nonspherical modes of a thick encapsulated MB filled with air and suspended in water. The shell material is assumed to be linear viscoelastic and quasi-incompressible...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27902473/rituximab-conjugated-doxorubicin-loaded-microbubbles-as-a-theranostic-modality-in-b-cell-lymphoma
#4
Shoubing Zhou, Xiu Zhang, Cailian Wang
This study evaluated rituximab-conjugated, doxorubicin-loaded microbubbles (RDMs) in combination with ultrasound as molecular imaging agents for early diagnosis of B cell lymphomas, and as a targeted drug delivery system. Rituximab, a monoclonal CD20 antibody, was attached to the surfaces of doxorubicin-loaded microbubbles. RDM binding to B cell lymphoma cells was assessed using immunofluorescence. The cytotoxic effects of RDMs in combination with ultrasound (RDMs+US) were evaluated in vitro in CD20+ and CD20- cell lines, and its antitumor activities were assessed in Raji (CD20+) and Jurkat (CD20-) lymphoma cell-grafted mice...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898015/optical-microbubble-resonators-with-high-refractive-index-inner-coating-for-bio-sensing-applications-an-analytical-approach
#5
Andrea Barucci, Simone Berneschi, Ambra Giannetti, Francesco Baldini, Alessandro Cosci, Stefano Pelli, Daniele Farnesi, Giancarlo C Righini, Silvia Soria, Gualtiero Nunzi Conti
The design of Whispering Gallery Mode Resonators (WGMRs) used as an optical transducer for biosensing represents the first and crucial step towards the optimization of the final device performance in terms of sensitivity and Limit of Detection (LoD). Here, we propose an analytical method for the design of an optical microbubble resonator (OMBR)-based biosensor. In order to enhance the OMBR sensing performance, we consider a polymeric layer of high refractive index as an inner coating for the OMBR. The effect of this layer and other optical/geometrical parameters on the mode field distribution, sensitivity and LoD of the OMBR is assessed and discussed, both for transverse electric (TE) and transverse magnetic (TM) polarization...
November 25, 2016: Sensors
https://www.readbyqxmd.com/read/27894841/in%C3%A2-vitro-investigation-of-ultrasound-induced-oxidative-stress-on-human-lens-epithelial-cells
#6
Patrick Rwei, Cihun-Siyong Alex Gong, Li-Jyuan Luo, Meng-Bo Lin, Jui-Yang Lai, Hao-Li Liu
The effect of ultrasound exposure on human lens epithelial cells (HLE-B3) was investigated in vitro, specifically on the generation of oxidative stress upon ultrasound application using various clinically-relevant settings. In addition to ultrasound-induced heat effects, oxidative stress has been recently proposed as one of the main mechanisms for ultrasound-induced effects on human cells. In this work, the levels of biocompatibility and generation of oxidative stress by exposure of ultrasound to HLE-B3 were evaluated quantitatively and qualitatively by the MTT assay, Live/Dead assay, reactive oxygen species (ROS) and intracellular calcium level...
November 26, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27892760/microbubble-mediated-ultrasound-drug-delivery-and-therapeutic-monitoring
#7
Charles A Sennoga, Emma Kanbar, Laurent Auboire, Paul-Armand Dujardin, Damien Fouan, Jean-Michel Escoffre, Ayache Bouakaz
Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues by employing different mechanisms of drug release is becoming feasible. Areas covered: We sought to describe: the nature and features of UCAs; outline current contrast-specific imaging modes; before describing a variety of strategies for using ultrasound and microbubbles as a drug delivery system...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27887768/evaluation-of-acute-kidney-injury-using-contrast-ultrasonography-in-a-rabbit-model-of-crush-syndrome
#8
Chundong Zhang, Xin Wang, Jie Tang
This study aimed to investigate the feasibility of evaluating acute kidney injury (AKI) using contrast ultrasonography in a rabbit model of crush syndrome. Sixty-four New Zealand white rabbits were anesthetized and the left hind limb was wrapped and compressed for 4 h with a sphygmomanometer. Contrast ultrasonography of the left kidney using microbubbles as the contrast medium was performed. The serum levels of blood urea nitrogen (BUN), creatine (Cr), creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in comparison to before the compression...
November 22, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27883051/lipid-coated-microbubbles-and-low-intensity-pulsed-ultrasound-enhance-chondrogenesis-of-human-mesenchymal-stem-cells-in-3d-printed-scaffolds
#9
Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar
Lipid-coated microbubbles are used to enhance ultrasound imaging and drug delivery. Here we apply these microbubbles along with low intensity pulsed ultrasound (LIPUS) for the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in a 3D printed poly-(ethylene glycol)-diacrylate (PEG-DA) hydrogel scaffold. The hMSC proliferation increased up to 40% after 5 days of culture in the presence of 0.5% (v/v) microbubbles and LIPUS in contrast to 18% with LIPUS alone...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876447/coating-microbubbles-with-nanoparticles-for-medical-imaging-and-drug-delivery
#10
Li Min Tay, Chenjie Xu
No abstract text is available yet for this article.
November 23, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27875218/entropy-of-ultrasound-contrast-agent-velocity-fields-for-angiogenesis-imaging-in-prostate-cancer
#11
Ruud van Sloun, Libertario Demi, Arnoud Postema, Jean de la Rosette, Hessel Wijkstra, Massimo Mischi
Prostate cancer care can benefit from accurate and cost-efficient imaging modalities that are able to reveal prognostic indicators for cancer. Angiogenesis is known to play a central role in the growth of tumors towards a metastatic or a lethal phenotype.With the aim of localizing angiogenic activity in a noninvasive manner, Dynamic Contrast Enhanced Ultrasound (DCEUS) has been widely used. Usually, the passage of ultrasound contrast agents thought the organ of interest is analyzed for the assessment of tissue perfusion...
November 16, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27872412/estimation-of-viscoelastic-properties-of-cells-using-acoustic-tweezing-cytometry
#12
Chunmei Yang, Di Chen, Xiaowei Hong
OBJECTIVES: Recently developed acoustic tweezing cytometry uses ultrasound-responsive targeted microbubbles for biomechanical stimulation of live cells at the subcellular level. The purpose of this research was to estimate the viscoelastic characteristics of cells from the displacements of cell-bound microbubbles in response to ultrasound pulses on acoustic tweezing cytometry. METHODS: Microbubbles were bound to NIH/3T3 fibroblasts and ATDC5 cells through an integrin-cytoskeleton linkage...
December 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27871988/sonoporation-with-acoustic-cluster-therapy-act%C3%A2-induces-transient-tumour-volume-reduction-in-a-subcutaneous-xenograft-model-of-pancreatic-ductal-adenocarcinoma
#13
Spiros Kotopoulis, Endre Stigen, Mihaela Popa, Mireia Mayoral Safont, Andrew Healey, Svein Kvåle, Per Sontum, Bjørn Tore Gjertsen, Odd Helge Gilja, Emmet McCormack
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with survival averaging only 3months if untreated following diagnosis. A major limitation in effectively treating PDAC using conventional and targeted chemotherapeutic agents, is inadequate drug delivery to the target location, predominantly due to a poorly vascularised, desmoplastic tumour microenvironment. Ultrasound in combination with ultrasound contrast agents, i.e., microbubbles, that flow through the vasculature and capillaries can be used to disrupt such mechanical barriers, potentially allowing for a greater therapeutic efficacy...
November 18, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27860550/contrast-enhanced-us-guided-interventions-improving-success-rate-and-avoiding-complications-using-us-contrast-agents
#14
Dean Y Huang, Gibran T Yusuf, Mohammad Daneshi, Mohammad Ali Husainy, Raymond Ramnarine, Maria E K Sellars, Paul S Sidhu
Ultrasonography (US) is an established modality for intervention. The introduction of microbubble US contrast agents (UCAs) has the potential to further improve US imaging for intervention. According to licensing, UCAs are currently approved for clinical use in restricted situations, but many additional indications have become accepted as having clinical value. The use of UCAs has been shown to be safe, and there is no risk of renal toxic effects, unlike with iodinated or gadolinium contrast medium. Broadly speaking, UCAs can be injected into the bloodstream (intravascular use) or instilled into almost any accessible body cavity (endocavitary use), either in isolation or synchronously...
November 18, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27858703/chronic-liver-disease-quantitative-mri-vs%C3%A2-ceus-based-microperfusion
#15
M Haimerl, S Poelsterl, L P Beyer, I Wiesinger, C Nießen, C Stroszczynski, P Wiggermann, E-M Jung
PURPOSE: To compare the diagnostic performance of MRI-based T1 relaxometry with dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation for evaluation of liver function. MATERIALS AND METHODS: 22 patients underwent Gd-EOB-DTPA-enhanced MRI with T1 relaxometry and previous or consecutive CEUS examinations. A transverse 3D VIBE sequence with an inline T1 calculation was acquired and the reduction rate of T1 relaxation time (rrT1) was evaluated. For CEUS measurements (1-6 MHz), a bolus injection of 1...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27857423/novel-double-step-approach-for-optical-sensing-via-microsphere-wgm-resonance
#16
G Palma, M C Falconi, F Starecki, V Nazabal, T Yano, T Kishi, T Kumagai, F Prudenzano
The use of resonant whispering gallery modes (WGMs) for sensing exhibits various drawbacks and critical points related to the microsphere and tapered optical fiber fabrication tolerance. The uncertainty on the fiber taper and microsphere geometry or the gap between the microsphere and the fiber taper can complicate or limit the actual use of these devices for sensing, requiring peculiar calibration of the WGM based sensing set-up. An alternative double-step approach is proposed in this paper. In particular, the geometrical parameters of the set-up are recovered preliminarily and then the rare earth parameters are recovered via simple transmittance/gain measurements...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27856230/a-comparison-in-therapeutic-efficacy-of-several-time-points-of-intravenous-stembell-administration-in-a-rat-model-of-acute-myocardial-infarction
#17
Reindert W Emmens, Maikel Oedayrajsingh-Varma, Linde Woudstra, Otto Kamp, Elisa Meinster, Annemieke van Dijk, Marco N Helder, Diana Wouters, Sacha Zeerleder, S Marieke van Ham, Nico de Jong, Hans W M Niessen, Lynda J M Juffermans, Paul A J Krijnen
BACKGROUND: Adipose-derived stromal cells (ASCs) are a promising new therapeutic option for patients with acute myocardial infarction (AMI). Previously, we found that ASCs coupled to antibody-targeted microbubbles (StemBells [StBs]) improved cardiac function when administered intravenously 7 days post-AMI in rats. In this study, we compared the efficacy of intravenous StB administration at different administration time points following AMI in rats. METHODS: AMI, followed by reperfusion, was induced in four groups of male Wistar rats, which subsequently received an intravenous 1 × 10(6) StB bolus 1 day post-AMI (StB1; n = 8), 7 days post-AMI (StB7; n = 9), at both time points (StB1+7; n = 7) or neither (Control; n = 7)...
November 14, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27855336/targeting-distinct-myeloid-cell-populations-in%C3%A2-vivo-using-polymers-liposomes-and-microbubbles
#18
Can Ergen, Felix Heymann, Wa'el Al Rawashdeh, Felix Gremse, Matthias Bartneck, Ulf Panzer, Robert Pola, Michal Pechar, Gert Storm, Nicole Mohr, Matthias Barz, Rudolf Zentel, Fabian Kiessling, Christian Trautwein, Twan Lammers, Frank Tacke
Identifying intended or accidental cellular targets for drug delivery systems is highly relevant for evaluating therapeutic and toxic effects. However, limited knowledge exists on the distribution of nano- and micrometer-sized carrier systems at the cellular level in different organs. We hypothesized that clinically relevant carrier materials, differing in composition and size, are able to target distinct myeloid cell subsets that control inflammatory processes, such as macrophages, neutrophils, monocytes and dendritic cells...
November 9, 2016: Biomaterials
https://www.readbyqxmd.com/read/27853587/magnetic-resonance-and-ultrasound-contrast-imaging-of-polymer-shelled-microbubbles-loaded-with-iron-oxide-nanoparticles
#19
Claudia Sciallero, Luca Balbi, Gaio Paradossi, Andrea Trucco
Dual-mode contrast agents (CAs) have great potential for improving diagnostics. However, the effectiveness of CAs is strictly related to both the solution adopted to merge the two agents into a single probe unit, and the ratio between the two agents. In this study, two dual-mode CAs for simultaneous magnetic resonance imaging (MRI) and ultrasound imaging (UI) were assessed. For this purpose, different densities of superparamagnetic iron oxide nanoparticles (SPIONs) were anchored to the external surface of polymer-shelled microbubbles (MBs) or were physically entrapped into the shell...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27853267/characterizing-focused-ultrasound-mediated-drug-delivery-to-the-heterogeneous-primate-brain-in-vivo-with-acoustic-monitoring
#20
Shih-Ying Wu, Carlos Sierra Sanchez, Gesthimani Samiotaki, Amanda Buch, Vincent P Ferrera, Elisa E Konofagou
Focused ultrasound with microbubbles has been used to noninvasively and selectively deliver pharmacological agents across the blood-brain barrier (BBB) for treating brain diseases. Acoustic cavitation monitoring could serve as an on-line tool to assess and control the treatment. While it demonstrated a strong correlation in small animals, its translation to primates remains in question due to the anatomically different and highly heterogeneous brain structures with gray and white matteras well as dense vasculature...
November 17, 2016: Scientific Reports
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