Dong Luo, Xinning Wang, Gopalakrishnan Ramamurthy, Ethan Walker, Lifang Zhang, Aditi Shirke, Naraen G Naidu, Clemens Burda, Reena Shakya, Eric T Hostnik, Mathew Joseph, Lee Ponsky, Vladimir Ponomarev, Thomas J Rosol, Michael F Tweedle, James P Basilion
BACKGROUND: Male dogs can develop spontaneous prostate cancer, which is similar physiologically to human disease. Recently, Tweedle and coworkers have developed an orthotopic canine prostate model allowing implanted tumors and therapeutic agents to be tested in a more translational large animal model. We used the canine model to evaluate prostate-specific membrane antigen (PSMA)-targeted gold nanoparticles as a theranostic approach for fluorescence (FL) imaging and photodynamic therapy (PDT) of early stage prostate cancer...
May 21, 2023: Prostate