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Cyclosporine-A dog

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https://www.readbyqxmd.com/read/29105868/successful-treatment-of-disseminated-nocardiosis-caused-by-nocardia-veterana-in-a-dog
#1
S Yaemsiri, J E Sykes
A 5-year-old male castrated Lhasa Apso cross was evaluated for a 1-month history of inappetence, lethargy, gagging, and progressive right thoracic limb lameness. Synovial fluid analysis revealed nonseptic suppurative inflammation, and a diagnosis of immune-mediated polyarthritis (IMPA) was made. After 3 months of treatment with prednisone and later cyclosporine, the dog developed multiple firm cutaneous and subcutaneous masses and a focal mass within the jejunum. Cultures of blood, urine, skin lesions, and the jejunal mass identified Nocardia veterana by matrix-absorption laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and allowed for earlier identification of the organism compared to more traditional secA1 gene sequencing...
November 4, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29018532/real-world-data-of-a-veterinary-teaching-hospital-in-japan-a-pilot-survey-of-prescribed-medicines
#2
Noriko Tanaka, Tsuyoshi Takizawa, Nao Miyamoto, Shinji Funayama, Ryo Tanaka, Syozo Okano, Toshio Iwasaki
The prescription data from a digital accounting system of a veterinary teaching hospital collected between 2008 and 2011 in Japan were downloaded, stored in a database and analysed using a statistical analysis software, SAS. Seventy-six per cent of all prescriptions were drugs approved for human beings. The most frequently prescribed category was 'Agents against pathogenic organisms', such as antibiotics and chemotherapeutic agents, followed by 'Cardiovascular agents'. Seventy-five per cent of prescribed oral formulations in the category 'Agents against pathogenic organisms' were drugs approved for human beings, while 78 per cent of the injectable prescriptions were those for veterinary...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/28958896/anti-inducible-costimulator-monoclonal-antibody-treatment-of-canine-chronic-graft-versus-host-disease
#3
Scott S Graves, Maura H Parker, Diane Stone, George E Sale, Smitha P S Pillai, Melissa M Johnson, Rainer Storb
In murine model systems inducible costimulator (ICOS) signaling has been implicated in the formation of chronic graft-versus-host disease (GVHD). Previously, we showed that chronic GVHD can be reproducibly produced in the dog hematopoietic cell transplantation (HCT) model and that ICOS expression is upregulated on T cells in dogs with chronic GVHD. The goal of the present study was to determine whether administration of a short course of anti-canine ICOS mAb could alter the rapid and progressive course of chronic GVHD...
September 25, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28905976/cutaneous-alternariosis-in-an-immunocompromised-dog-successfully-treated-with-cold-plasma-and-cessation-of-immunosuppressive-medication
#4
Janine Classen, Berrett Dengler, Christoph J Klinger, Sonya V Bettenay, Volker Rickerts, Ralf S Mueller
A cutaneous infection with Alternaria spp. was diagnosed in a 2-year-old male intact Irish setter dog, presenting with multifocal papules, plaques and ulcerations involving all four distal limbs, shoulder blades, scrotum, pinnae and nasal mucous membranes. The dog had been treated for inflammatory bowel disease and lymphangiectasia with immunosuppressive doses of cyclosporine and prednisolone for approximately 3 months. The diagnosis was based on clinical signs, the demonstration of fungal elements within skin biopsies, deep fungal culture and fungal PCR from a formalin-fixed tissue specimen...
September 13, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28887897/opportunistic-invasive-cutaneous-fungal-infections-associated-with-administration-of-cyclosporine-to-dogs-with-immune-mediated-disease
#5
B B McAtee, K J Cummings, A K Cook, J A Lidbury, J C Heseltine, M D Willard
BACKGROUND: Opportunistic invasive fungal infections (OIFIs) occur in dogs administered immunosuppressive medications. However, the epidemiology of OIFIs among dogs undergoing immunosuppressive treatment is poorly understood. The aims of this study were to (1) estimate the incidence of OIFIs among dogs diagnosed with certain immune-mediated diseases and treated with immunosuppressive drugs, and (2) determine if administration of particular drug(s) was a risk factor for OIFIs. HYPOTHESIS: Dogs receiving cyclosporine treatment (alone or as part of a multidrug protocol) are at higher risk of developing OIFIs...
September 9, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28804552/in-vivo-opening-of-the-mitochondrial-permeability-transition-pore-in-a-rat-model-of-ventricular-fibrillation-and-closed-chest-resuscitation
#6
Iyad M Ayoub, Jeejabai Radhakrishnan, Raúl J Gazmuri
Opening of the mitochondrial permeability transition pore (mPTP) is considered central to reperfusion injury. Yet, most of our knowledge comes from observations in isolated mitochondria, cells, and organs. We used a rat model of ventricular fibrillation (VF) and closed-chest resuscitation to examine whether the mPTP opens in vivo and whether cyclosporine A (CsA) attenuates the associated myocardial injury. Two series of 26 and 18 rats each underwent 10 minutes of untreated VF before attempting resuscitation...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28750792/heat-shock-proteins-70kda-eosinophil-cationic-protein-and-nitric-oxide-during-chronic-superficial-keratitis-in-dogs
#7
Renata Urban-Chmiel, Ireneusz Balicki, Andrzej Wernicki
The objective of the study is to determine the levels of eosinophil cationic protein (ECP), heat shock proteins 70, and nitric oxide ions measured as nitrite ions (Griess reaction) in dogs with chronic superficial keratitis (CSK). The study was conducted on 24 dogs with CSK. Blood sera from the animals were tested for concentrations of heat shock proteins 70, ECP, and nitrite ions before treatment and again 5 weeks and 6 months after treatment. Dogs with CSK were treated for 6 months with various regimes involving the use of ophthalmic drops containing dexamethasone, dimethyl sulfoxide, and cyclosporine...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28294507/exophthalmos-due-to-sterile-neutrophilic-dermatosis-in-a-dog
#8
Emily K Sharpe, Jessica M Meekins, Mary Bagladi-Swanson, Amy J Rankin
An 8-year-old castrated male Bichon Frise was presented to the Kansas State University Veterinary Health Center for evaluation of unilateral right-sided exophthalmos, suspected secondary to a retrobulbar abscess. The dog had acutely developed right-sided periorbital swelling, exophthalmos with pain on retropulsion, as well as multiple cutaneous exudative plaques on the feet and tail base. On ophthalmic examination, the dog also exhibited mild left-sided exophthalmos with decreased, nonpainful retropulsion. Orbital ultrasound and CT were performed to evaluate the extent of bilateral orbital disease...
March 14, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28190562/a-combined-approach-to-early-detect-in-vitro-drug-induced-hemostatic-changes-in-preclinical-safety
#9
Myriam Defontis, Serge Côté, David Ledieu
Early detection of drug-induced alterations of hemostasis is challenging. Drugs can affect different components of the Virchow's triad and measurement of plasmatic coagulation times lacks sensitivity. New techniques for a more global assessment of the hemostasis are now available: the impedance platelet aggregometry, the thromboelastography and the thrombin generation measurement. The aim of this study was to evaluate three techniques (i.e.: Multiplate(®), TEG(®) and CAT) for the in vitro detection of the effect of a drug known to induce hemostatic alterations in a preclinical safety environment...
February 9, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28160307/treatment-of-presumptive-primary-immune-mediated-thrombocytopenia-with-mycophenolate-mofetil-versus-cyclosporine-in-dogs
#10
F O Cummings, S A Rizzo
OBJECTIVES: The objective of this study was to compare hospitalisation duration, survival times, adverse events and cost of therapy in dogs with presumptive primary immune-mediated thrombocytopenia undergoing therapy with mycophenolate mofetil and corticosteroids versus cyclosporine and corticosteroids. METHODS: A retrospective study of medical case records of dogs with presumed primary immune-mediated thrombocytopenia was conducted. Data collected included signalment, presenting complaints, haematologic and biochemical profiles, vector-borne disease testing, thoracic and abdominal radiographs, abdominal ultrasound, medications administered, duration of hospitalisation, 30- and 60-day survival, adverse events and cost of therapy...
February 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28013013/a-canine-model-of-chronic-graft-versus-host-disease
#11
Scott S Graves, Andrew Rezvani, George Sale, Diane Stone, Maura Parker, Steven Rosinski, Michele Spector, Bruce Swearingen, Leslie Kean, Rainer Storb
In long-term survivors of allogeneic hematopoietic cell transplantation (HCT), chronic graft-versus-host disease (GVHD) is the major cause of morbidity and mortality and a major determinant of quality of life. Chronic GVHD responds poorly to current immunosuppressive drugs, and while T cell depletion may be preventive, this gain is offset by increased relapse rates. A significant impediment to progress in treating chronic GVHD has been the limitations of existing animal models. The goal of this study was to develop a reproducible comprehensive model of chronic GVHD in the dog...
March 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27861292/long-term-tolerance-toward-haploidentical-vascularized-composite-allograft-transplantation-in-a-canine-model-using-bone-marrow-or-mobilized-stem-cells
#12
Jeff Chang, Scott S Graves, Tiffany Butts-Miwongtum, George E Sale, Rainer Storb, David Woodbridge Mathes
BACKGROUND: The development of safe and reliable protocols for the transplantation of the face and hands may be accomplished with animal modeling of transplantation of vascularized composite allografts (VCA). Previously, we demonstrated that tolerance to a VCA could be achieved after canine recipients were simultaneously given marrow from a dog leukocyte antigen-identical donor. In the present study, we extend those findings across a dog leukocyte antigen mismatched barrier. METHODS: Eight recipient dogs received total body irradiation (4...
December 2016: Transplantation
https://www.readbyqxmd.com/read/27774659/the-role-of-drug-efflux-pumps-in-malassezia-pachydermatis-and-malassezia-furfur-defence-against-azoles
#13
Roberta Iatta, Maria Rita Puttilli, Davide Immediato, Domenico Otranto, Claudia Cafarchia
This study aims to evaluate the effect of efflux pump modulators (EPMs) on the minimal inhibitory concentration (MIC) of fluconazole (FLZ) and voriconazole (VOR) in Malassezia furfur and Malassezia pachydermatis. The in vitro efficacy of azoles, in combination with EPMs (ie haloperidol-HAL, promethazine-PTZ and cyclosporine A-CYS), against 21 M. furfur from bloodstream infection patients and 14 M. pachydermatis from the skin of dogs with dermatitis, was assessed using a broth microdilution chequerboard analysis...
March 2017: Mycoses
https://www.readbyqxmd.com/read/27761982/assessment-of-tear-film-osmolarity-using-the-tearlab-%C3%A2-osmometer-in-normal-dogs-and-dogs-with-keratoconjunctivitis-sicca
#14
Lionel Sebbag, Shin Ae Park, Philip H Kass, David J Maggs, Mayssa Attar, Christopher J Murphy
OBJECTIVE: To evaluate repeatability and reproducibility of tear osmolarity measured using the TearLab(™) osmometer in normal dogs and to assess its diagnostic potential in dogs with keratoconjunctivitis sicca (KCS). ANIMALS STUDIED: Beagle dogs; six normal and five with KCS. PROCEDURES: Tear osmolarity and Schirmer tear test-1 (STT-1) values were obtained at various times. Normal dogs were assessed for diurnal variation and repeatability and reproducibility of measurements...
October 20, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27760033/cyclosporin-a-treatment-in-intrinsic-canine-atopic-dermatitis-atopic-like-dermatitis-open-trial-study
#15
M Fujimura, Y Nakatsuji, H Ishimaru
In this study, dogs were separated into two groups and treated with immunosuppressant (Cyclosporin A: CsA). The first group was the canine atopic dermatitis (CAD) group, which is similar to extrinsic atopic dermatitis (AD) in humans (treated with a CsA dose of 2.5-5.5 mg/kg, n=8), and the second group was the canine atopic-like dermatitis (ALD) group, which is similar to intrinsic AD in humans (treated with a CsA dose of 2.5-6.5 mg/kg, n=14). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (PRE) and after treatment (POST) to assess the effectiveness of CsA for the two groups...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27681267/long-term-tolerance-towards-haploidentical-vascularized-composite-allograft-transplantation-in-a-canine-model-using-bone-marrow-or-mobilized-stem-cells
#16
Jeff Chang, Scott S Graves, Tiffany Butts-Miwongtum, George E Sale, Rainer Storb, David W Mathes
BACKGROUND: The development of safe and reliable protocols for the transplantation of the face and hands may be accomplished with animal modeling of transplantation of vascularized composite allografts (VCA). Previously, we demonstrated that tolerance to a VCA could be achieved after canine recipients were simultaneously given marrow from a dog leukocyte antigen (DLA) identical donor. In the present study, we extend those findings across a DLA mismatched barrier. METHODS: Eight Recipient dogs received total body irradiation (4...
September 27, 2016: Transplantation
https://www.readbyqxmd.com/read/27586063/evaluation-of-the-effect-of-fluconazole-on-the-pharmacokinetics-of-cyclosporin-a-in-healthy-dogs-after-a-single-dose-and-at-steady-state
#17
J B Pieper, L Dirikolu, K L Campbell, Z Li, M A Mitchell
The aim of the study was to describe the effect of fluconazole on the pharmacokinetics of cyclosporin A in healthy dogs when investigated as a single dose and at steady-state. Five healthy adult dogs were used in the study in a crossover design receiving either 5 mg/kg of cyclosporin A (CsA) alone or 5 mg/kg of fluconazole with 2.5 mg/kg of cyclosporin A (CsA/Flu) for 35 days. Pharmacokinetic curves were performed on day 1 and day 35 in addition to sampling trough and suspected peak concentrations (C2) twice weekly with LC/MS/MS...
September 1, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27381604/graft-versus-host-disease-in-a-dog-after-reduced-intensity-hematopoietic-stem-cell-transplantation-from-a-dla-identical-littermate
#18
Stephanie Schaefer, Juliane Werner, Sandra Lange, Christoph Machka, Gudrun Knuebel, Anett Sekora, Catrin Roolf, Tido Winkler, Hugo Murua Escobar, Ingo Nolte, Christian Junghanss
BACKGROUND: Graft-versus-host disease (GvHD) is an adverse effect following hematopoietic stem cell transplantation (HSCT) in humans. Dogs represent a key model organism for the development of treatment protocols for HSCT. However, detailed descriptions of canine GvHD and its treatment are rare. Herein we describe the development of canine GvHD and therapeutic intervention. MATERIALS AND METHODS: A female Beagle received an allogeneic HSCT from a dog leukocyte antigen-identical littermate (conditioning with 4...
July 2016: In Vivo
https://www.readbyqxmd.com/read/27259309/evaluation-of-immunosuppressive-activity-of-demethylzeylasteral-in-a-beagle-dog-kidney-transplantation-model
#19
Huimin An, Yu Zhu, Wenping Xu, Yujun Liu, Jianping Zhang, Zongming Lin
Several monomers isolated from Tripterygium wilfordii Hook f. (Celastraceae) have attracted worldwide interest. In this study, we established a simple and reliable kidney transplantation model in beagle dog to evaluate the immunosuppressive activity of demethylzeylasteral (T-96), an immunosuppressive monomer isolated from the root xylem of T. wilfordii. Recipient and donor male beagle dogs were obtained from two different breeders to ensure MHC mismatching. All dogs were randomly divided into six groups following kidney transplantation, and different doses of T-96 or cyclosporine A (CsA) were administered to each group during 14 days of observation...
December 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27241238/corneal-grafting-for-the-treatment-of-full-thickness-corneal-defects-in-dogs-a-review-of-50-cases
#20
Rodrigo P Lacerda, Maria T Peña Gimenez, Fernando Laguna, Daniel Costa, Jose Ríos, Marta Leiva
OBJECTIVE: To describe corneal grafting for the treatment of full-thickness corneal defects in dogs and to determine its effectiveness in preserving vision. METHODS: A review of the medical records of dogs that underwent corneal grafting following corneal perforations (≥3 mm) at the VTH-UAB from 2002 to 2012 was carried out. RESULTS: Fifty dogs of different breed, age and gender were included. Brachycephalic breeds were overrepresented (37/50;74%)...
May 2017: Veterinary Ophthalmology
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