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Cyclosporine-A dog

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https://www.readbyqxmd.com/read/27861292/long-term-tolerance-toward-haploidentical-vascularized-composite-allograft-transplantation-in-a-canine-model-using-bone-marrow-or-mobilized-stem-cells
#1
Jeff Chang, Scott S Graves, Tiffany Butts-Miwongtum, George E Sale, Rainer Storb, David Woodbridge Mathes
BACKGROUND: The development of safe and reliable protocols for the transplantation of the face and hands may be accomplished with animal modeling of transplantation of vascularized composite allografts (VCA). Previously, we demonstrated that tolerance to a VCA could be achieved after canine recipients were simultaneously given marrow from a dog leukocyte antigen-identical donor. In the present study, we extend those findings across a dog leukocyte antigen mismatched barrier. METHODS: Eight recipient dogs received total body irradiation (4...
December 2016: Transplantation
https://www.readbyqxmd.com/read/27774659/the-role-of-drug-efflux-pumps-in-malassezia-pachydermatis-and-malassezia-furfur-defence-against-azoles
#2
Roberta Iatta, Maria Rita Puttilli, Davide Immediato, Domenico Otranto, Claudia Cafarchia
This study aims to evaluate the effect of efflux pump modulators (EPMs) on the minimal inhibitory concentration (MIC) of fluconazole (FLZ) and voriconazole (VOR) in Malassezia furfur and Malassezia pachydermatis. The in vitro efficacy of azoles, in combination with EPMs (ie haloperidol-HAL, promethazine-PTZ and cyclosporine A-CYS), against 21 M. furfur from bloodstream infection patients and 14 M. pachydermatis from the skin of dogs with dermatitis, was assessed using a broth microdilution chequerboard analysis...
October 24, 2016: Mycoses
https://www.readbyqxmd.com/read/27761982/assessment-of-tear-film-osmolarity-using-the-tearlab-%C3%A2-osmometer-in-normal-dogs-and-dogs-with-keratoconjunctivitis-sicca
#3
Lionel Sebbag, Shin Ae Park, Philip H Kass, David J Maggs, Mayssa Attar, Christopher J Murphy
OBJECTIVE: To evaluate repeatability and reproducibility of tear osmolarity measured using the TearLab(™) osmometer in normal dogs and to assess its diagnostic potential in dogs with keratoconjunctivitis sicca (KCS). ANIMALS STUDIED: Beagle dogs; six normal and five with KCS. PROCEDURES: Tear osmolarity and Schirmer tear test-1 (STT-1) values were obtained at various times. Normal dogs were assessed for diurnal variation and repeatability and reproducibility of measurements...
October 20, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27760033/cyclosporin-a-treatment-in-intrinsic-canine-atopic-dermatitis-atopic-like-dermatitis-open-trial-study
#4
M Fujimura, Y Nakatsuji, H Ishimaru
In this study, dogs were separated into two groups and treated with immunosuppressant (Cyclosporin A: CsA). The first group was the canine atopic dermatitis (CAD) group, which is similar to extrinsic atopic dermatitis (AD) in humans (treated with a CsA dose of 2.5-5.5 mg/kg, n=8), and the second group was the canine atopic-like dermatitis (ALD) group, which is similar to intrinsic AD in humans (treated with a CsA dose of 2.5-6.5 mg/kg, n=14). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (PRE) and after treatment (POST) to assess the effectiveness of CsA for the two groups...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27681267/long-term-tolerance-towards-haploidentical-vascularized-composite-allograft-transplantation-in-a-canine-model-using-bone-marrow-or-mobilized-stem-cells
#5
Jeff Chang, Scott S Graves, Tiffany Butts-Miwongtum, George E Sale, Rainer Storb, David W Mathes
BACKGROUND: The development of safe and reliable protocols for the transplantation of the face and hands may be accomplished with animal modeling of transplantation of vascularized composite allografts (VCA). Previously, we demonstrated that tolerance to a VCA could be achieved after canine recipients were simultaneously given marrow from a dog leukocyte antigen (DLA) identical donor. In the present study, we extend those findings across a DLA mismatched barrier. METHODS: Eight Recipient dogs received total body irradiation (4...
September 27, 2016: Transplantation
https://www.readbyqxmd.com/read/27586063/evaluation-of-the-effect-of-fluconazole-on-the-pharmacokinetics-of-cyclosporin-a-in-healthy-dogs-after-a-single-dose-and-at-steady-state
#6
J B Pieper, L Dirikolu, K L Campbell, Z Li, M A Mitchell
The aim of the study was to describe the effect of fluconazole on the pharmacokinetics of cyclosporin A in healthy dogs when investigated as a single dose and at steady-state. Five healthy adult dogs were used in the study in a crossover design receiving either 5 mg/kg of cyclosporin A (CsA) alone or 5 mg/kg of fluconazole with 2.5 mg/kg of cyclosporin A (CsA/Flu) for 35 days. Pharmacokinetic curves were performed on day 1 and day 35 in addition to sampling trough and suspected peak concentrations (C2) twice weekly with LC/MS/MS...
September 1, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27381604/graft-versus-host-disease-in-a-dog-after-reduced-intensity-hematopoietic-stem-cell-transplantation-from-a-dla-identical-littermate
#7
Stephanie Schaefer, Juliane Werner, Sandra Lange, Christoph Machka, Gudrun Knuebel, Anett Sekora, Catrin Roolf, Tido Winkler, Hugo Murua Escobar, Ingo Nolte, Christian Junghanss
BACKGROUND: Graft-versus-host disease (GvHD) is an adverse effect following hematopoietic stem cell transplantation (HSCT) in humans. Dogs represent a key model organism for the development of treatment protocols for HSCT. However, detailed descriptions of canine GvHD and its treatment are rare. Herein we describe the development of canine GvHD and therapeutic intervention. MATERIALS AND METHODS: A female Beagle received an allogeneic HSCT from a dog leukocyte antigen-identical littermate (conditioning with 4...
July 2016: In Vivo
https://www.readbyqxmd.com/read/27259309/evaluation-of-immunosuppressive-activity-of-demethylzeylasteral-in-a-beagle-dog-kidney-transplantation-model
#8
Huimin An, Yu Zhu, Wenping Xu, Yujun Liu, Jianping Zhang, Zongming Lin
Several monomers isolated from Tripterygium wilfordii Hook f. (Celastraceae) have attracted worldwide interest. In this study, we established a simple and reliable kidney transplantation model in beagle dog to evaluate the immunosuppressive activity of demethylzeylasteral (T-96), an immunosuppressive monomer isolated from the root xylem of T. wilfordii. Recipient and donor male beagle dogs were obtained from two different breeders to ensure MHC mismatching. All dogs were randomly divided into six groups following kidney transplantation, and different doses of T-96 or cyclosporine A (CsA) were administered to each group during 14 days of observation...
December 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27241238/corneal-grafting-for-the-treatment-of-full-thickness-corneal-defects-in-dogs-a-review-of-50-cases
#9
Rodrigo P Lacerda, Maria T Peña Gimenez, Fernando Laguna, Daniel Costa, Jose Ríos, Marta Leiva
OBJECTIVE: To describe corneal grafting for the treatment of full-thickness corneal defects in dogs and to determine its effectiveness in preserving vision. METHODS: A review of the medical records of dogs that underwent corneal grafting following corneal perforations (≥3 mm) at the VTH-UAB from 2002 to 2012 was carried out. RESULTS: Fifty dogs of different breed, age and gender were included. Brachycephalic breeds were overrepresented (37/50;74%)...
May 31, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27170302/identification-in-grmd-dog-muscle-of-critical-mirnas-involved-in-pathophysiology-and-effects-associated-with-mustem-cell-transplantation
#10
Florence Robriquet, Candice Babarit, Thibaut Larcher, Laurence Dubreil, Mireille Ledevin, Hélicia Goubin, Karl Rouger, Laëtitia Guével
BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked muscle disease that leads to fibre necrosis and progressive paralysis. At present, DMD remains a lethal disease without any effective treatment, requiring a better understanding of the pathophysiological processes and comprehensive assessment of the newly identified therapeutic strategies. MicroRNAs including members of the muscle-specific myomiR family have been identified as being deregulated in muscle of DMD patients and in mdx mice used as a model for DMD...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27156005/the-effects-of-cyclosporine-and-aspirin-on-platelet-function-in-normal-dogs
#11
J Thomason, T Archer, R Wills, S Press, A Mackin
BACKGROUND: Cyclosporine increases thromboxane synthesis in dogs, potentially increasing the thrombogenic properties of platelets. HYPOTHESIS/OBJECTIVES: Our hypothesis was that the concurrent administration of low-dose aspirin and cyclosporine would inhibit cyclosporine-associated thromboxane synthesis without altering the antiplatelet effects of aspirin. The objective was to determine the effects of cyclosporine and aspirin on primary hemostasis. ANIMALS: Seven healthy dogs...
July 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27085046/readily-restoring-freeze-dried-probilosomes-as-potential-nanocarriers-for-enhancing-oral-delivery-of-cyclosporine-a
#12
Peipei Guan, Yi Lu, Jianping Qi, Wei Wu
Formulating vesicular nanocarriers into dried precursors so as to overcome the drawbacks associated with liquid formulations is challengeable due to low efficiency of restoration. In this study, bilosomes interiorly thickened with gelatin (G-BLs) was evaluated for the ability to withstand freeze-drying stress and enhanced oral bioavailability of a model drug, cyclosporine A (CyA). The restoration efficiency of freeze-dried pro-G-BLs is investigated by comparing the particle size distribution, entrapment efficiency and morphology of the bilosomes before and after freeze-drying...
August 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27071733/keratoconjunctivitis-sicca-exacerbation-in-a-dog-treated-with-systemic-atenolol
#13
G Barsotti, T Vezzosi
A 6-year-old, intact, male English cocker spaniel was referred for treatment of chronic conjunctivitis and unilateral keratitis. The dog was diagnosed with bilateral immune-mediated keratoconjunctivitis sicca, treated with topical cyclosporine 0·2% ointment and sodium hyaluronate eye drops and improved considerably. After 2 months, pulmonic stenosis was diagnosed, and the dog commenced treatment with oral atenolol; the ophthalmological disease worsened dramatically within a few days. The ophthalmic signs rapidly improved after discontinuation of atenolol, and there was bilateral complete remission after 3 weeks...
July 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27000539/inhibition-of-bile-salt-transport-by-drugs-associated-with-liver-injury-in-primary-hepatocytes-from-human-monkey-dog-rat-and-mouse
#14
Jie Zhang, Kan He, Lining Cai, Yu-Chuan Chen, Yifan Yang, Qin Shi, Thomas F Woolf, Weigong Ge, Lei Guo, Jürgen Borlak, Weida Tong
Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of bile salts from their precursors in primary human, monkey, dog, rat, and mouse hepatocytes in suspension as well as LC-MS/MS determination of extracellular bile salts transported out of hepatocytes. Glycine- and taurine-conjugated bile acids were rapidly formed in hepatocytes and effectively transported into the extracellular medium...
August 5, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26975448/evaluation-of-cyclosporine-sparing-effects-of-polyunsaturated-fatty-acids-in-the-treatment-of-canine-atopic-dermatitis
#15
M R Müller, M Linek, C Löwenstein, A Röthig, K Doucette, K Thorstensen, R S Mueller
A randomised, double-blinded, placebo-controlled multicentre trial was conducted in 36 dogs with atopic dermatitis to evaluate the cyclosporine-sparing effect of polyunsaturated fatty acids. Dogs were stable on their individual cyclosporine dosage and received either a mainly omega-3 fatty acid product with a minor omega-6 fatty acid fraction or placebo, orally for 12 weeks. Dogs were examined every 4 weeks and the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) was determined by a clinician...
April 2016: Veterinary Journal
https://www.readbyqxmd.com/read/26829271/comparison-of-the-efficacy-of-prednisone-and-cyclosporine-for-treatment-of-dogs-with-primary-immune-mediated-polyarthritis
#16
Amy C Rhoades, William Vernau, Philip H Kass, Melissa A Herrera, Jane E Sykes
OBJECTIVE: To compare efficacy between cyclosporine and prednisone for treatment of primary immune-mediated polyarthritis (IMPA) in dogs. DESIGN: Randomized controlled clinical trial. ANIMALS: 20 client-owned dogs with primary IMPA. PROCEDURES: Dogs were randomly assigned to receive prednisone (starting at 1 mg/kg [0.45 mg/lb], PO, q 12 h; n = 10) or cyclosporine (5 mg/kg [2.3 mg/lb], PO, q 12 h; 10) for 90 days. Cyclosporine-treated dogs also received carprofen, tramadol, or both for the first 7 days for analgesia...
February 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/26802322/low-radiation-dose-and-low-cell-dose-increase-the-risk-of%C3%A2-graft-rejection-in-a-canine-hematopoietic-stem-cell-transplantation-model
#17
Sandra Lange, Anne Steder, Änne Glass, Doreen Killian, Susanne Wittmann, Christoph Machka, Juliane Werner, Stephanie Schäfer, Catrin Roolf, Christian Junghanss
The canine hematopoietic stem cell transplantation (HSCT) model has become accepted in recent decades as a good preclinical model for the development of new transplantation strategies. Information on factors associated with outcome after allogeneic HSCT are a prerequisite for designing new risk-adapted transplantation protocols. Here we report a retrospective analysis aimed at identifying risk factors for allograft rejection in the canine HSCT model. A total of 75 dog leukocyte antigen-identical sibling HSCTs were performed since 2003 on 10 different protocols...
April 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26676223/effects-of-oral-cyclosporine-on-canine-t-cell-expression-of-il-2-and-ifn-gamma-across-a-12-h-dosing-interval
#18
C L Fellman, T M Archer, J V Stokes, R W Wills, K V Lunsford, A J Mackin
The duration of immunosuppressive effects following oral cyclosporine in dogs is unknown. This study used flow cytometry and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) to evaluate the effects of high-dose oral cyclosporine across a 12-h dosing interval. Expression of interleukin-2 (IL-2) and interferon-gamma (IFN-γ) was compared before and after 8 days of cyclosporine at 10 mg/kg every 12 h in six healthy dogs. Samples were collected at 0, 2, 4, and 8 h postdosing for analysis of unactivated and activated T-cell and whole blood cytokine expression using flow cytometry and qRT-PCR, respectively, and at 0, 2, 4, 6, 8, and 10 h postdosing for measurement of cyclosporine concentrations...
June 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26645335/deep-anterior-lamellar-keratoplasty-of-dog-eyes-using-the-big-bubble-technique
#19
Soohyun Kim, Ji Yoon Kwak, Manbok Jeong, Kangmoon Seo
This study was conducted to establish the feasibility of corneal transplantation using the big-bubble technique (BBT) to perform deep anterior lamellar keratoplasty (DALK) in three dogs. After the cornea was trephined 750 µm, 4 mL of air was injected, and the blanched stroma was removed to expose Descemet's membrane (DM). The donor corneal button, which was gently stripped off the DM, was sutured onto the bare DM of the recipient cornea. The dogs received topical antibiotics every 6 h for 7 days and 2% cyclosporine ointment every 12 h for 1 month...
September 30, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/26623280/a-case-of-non-regenerative-immune-mediated-anemia-treated-by-combination-therapy-of-human-immune-globulin-and-mycophenolate-mofetil-in-a-dog
#20
M Yuki
A 12-year-old female Shih Tzu dog was referred with diarrhea. Hematological examination indicated severe non-regenerative anemia. Bone marrow aspiration smears and core biopsy specimens revealed normal bone marrow. Based on those results, non-regenerative immune-mediated anemia was diagnosed. The dog was initially treated using prednisolone and cyclosporine. However, this treatment regimen did not prove effective. Nevertheless, the patient achieved a good hematological response after the administration of a combination therapy of human immune globulin and mycophenolate mofetil...
2011: Open veterinary journal
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