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Cyclosporin "immune mediated"

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https://www.readbyqxmd.com/read/27681743/the-clinical-diagnosis-and-management-of-kawasaki-disease-a-review-and-update
#1
REVIEW
Frank H Zhu, Jocelyn Y Ang
Kawasaki disease is an acute, self-limited vasculitis of childhood and has become the leading cause of acquired pediatric heart disease in the USA. Prompt treatment is essential in reducing cardiac-related morbidity and mortality. The underlying etiology remains unknown. The disease itself may be the characteristic manifestation of a common pathway of immune-mediated vascular inflammation in susceptible hosts. The characteristic clinical features of fever for at least 5 days with bilateral nonpurulent conjunctivitis, rash, changes in lips and oral cavity, changes in peripheral extremities, and cervical lymphadenopathy remain the mainstay of diagnosis...
September 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27551545/the-pro-oxidative-drug-wf-10-inhibits-serial-killing-by-primary-human-cytotoxic-t-cells
#2
G H Wabnitz, E Balta, S Schindler, H Kirchgessner, B Jahraus, S Meuer, Y Samstag
Cytotoxic T-cells (CTLs) play an important role in many immune-mediated inflammatory diseases. Targeting cytotoxicity of CTLs would allow to interfere with immune-mediated tissue destruction. Here we demonstrate that WF-10, a pro-oxidative compound, inhibits CTL-mediated cytotoxicity. WF-10 did not influence early steps of target-cell killing, but impaired the ability of CTLs to detach from the initial target cell and to move to a second target cell. This reduced serial killing was accompanied by stronger enrichment of the adhesion molecule LFA-1 in the cytolytic immune synapse...
2016: Cell Death Discovery
https://www.readbyqxmd.com/read/27416278/exploring-an-animal-model-of-amodiaquine-induced-liver-injury-in-rats-and-mice
#3
Feng Liu, Ping Cai, Imir Metushi, Jinze Li, Tetsuya Nakayawa, Libia Vega, Jack Uetrecht
Amodiaquine (AQ) is associated with a relatively high incidence of idiosyncratic drug-induced liver injury (IDILI) and agranulocytosis. A previous study reported that a combination of high dose AQ and glutathione (GSH) depletion led to liver injury. However, the characteristics of this toxicity were very different from AQ-induced liver injury in humans. We developed a model of AQ-induced liver injury with characteristics similar to the injury in humans by treating mice with lower doses of AQ for several weeks...
September 2016: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/27411805/considerations-for-systemic-treatment-of-psoriasis-in-obese-patients
#4
REVIEW
Paolo Gisondi, Micol Del Giglio, Giampiero Girolomoni
Psoriasis is an immune-mediated inflammatory skin disease frequently associated with metabolic disorders, including diabetes, dyslipidaemia and metabolic syndrome. Moreover, a growing number of studies confirm the association between psoriasis and obesity. It has been found that obesity, as measured by body mass index >30 kg/m(2), can double the risk of incident psoriasis. A positive correlation between different measures of adiposity and the severity of psoriasis has also been reported. Epidemiologic studies have also provided robust evidence confirming the association between obesity and psoriatic arthritis...
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27404498/treatment-of-aplastic-anaemia-with-lower-dose-anti-thymocyte-globulin-atgam-produces-similar-response-rates-and-survival-as-per-standard-dose-atgam-schedules
#5
Ashleigh Scott, Kirk Morris, Jason Butler, Anthony K Mills, Glen A Kennedy
BACKGROUND: plastic anaemia (AA) is a rare acquired bone marrow failure syndrome resulting from immune mediated destruction of haematopoietic stem cells (HSC). For adults in whom first-line haematopoietic progenitor cell transplantation (HPCT) is not feasible, combination anti-thymocyte globulin (ATGAM) plus cyclosporine A (CsA) is standard therapy; however, there is minimal data available regarding the optimal ATGAM dosage in terms of efficacy and survival. AIMS: Our institutions have historically used different dosing protocols of ATGAM in the treatment of AA...
July 12, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27306529/calcineurin-inhibitor-nephrotoxicity-through-the-lens-of-longitudinal-histology-comparison-of-cyclosporine-and-tacrolimus-eras
#6
Brian J Nankivell, Chow H PʼNg, Philip J OʼConnell, Jeremy R Chapman
BACKGROUND: The contribution of calcineurin inhibitors (CNI) nephrotoxicity to progressive kidney transplant injury remains debated, with little long-term data from the modern tacrolimus (TAC) era using lower doses. METHODS: This longitudinal cohort study evaluated histological evidence of CNI nephrotoxicity from normal donor kidneys of successful kidney-pancreas transplant recipients during cyclosporine (CSA) and TAC eras, analyzed by intention-to-treat. RESULTS: From 200 patients, 1622 adequate prospective protocol (84...
August 2016: Transplantation
https://www.readbyqxmd.com/read/27263622/an-autoimmune-lymphoproliferative-syndrome-initially-diagnosed-as-evans-syndrome
#7
Zümrüt Uysal, Mehmet Ertem, Dilber Talia İleri, Figen Doğu, Fatih Mehmet Azık, Aydan İkincioğulları, Sevgi Gözdaşoğlu
Autoimmune lymphoproliferative syndrome (ALPS) is a rare childhood disorder characterized by chronic non-malignant lymphoproliferation and autoimmunity. Patients with ALPS frequently exhibit episodic and intermittent, severe autoimmune- induced hemolytic anemia, thrombocytopenia or combined cytopenias. The co-occurrence of immune-mediated cytopenias, autoimmune thrombocytopenia and autoimmune hemolytic anemia is also known as Evans syndrome. This report describes a child who presented with Evans syndrome symptoms and who, after the detection of increased percentage of double negative T cell population in the peripheral blood, was diagnosed as ALPS...
June 5, 2007: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27246353/mycophenolate-mofetil-as-an-alternative-treatment-for-autoimmune-hepatitis
#8
Seung Woon Park, Soon Ho Um, Han Ah Lee, Sang Hyun Kim, Yura Sim, Sun Young Yim, Yeon Seok Seo, Ho Sang Ryu
Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease characterized by hepatocellular inflammation, necrosis, and fibrosis, which can progress to cirrhosis and fulminant hepatic failure. The standard treatment for AIH includes corticosteroids alone or in combination with azathioprine. Although most patients achieve remission using the standard regimen, some patients do not respond due to either drug intolerance or refractory disease; in such cases alternative immunosuppressive agents should be explored...
June 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/27213490/calcineurin-inhibitor-sparing-strategies-in-renal-transplantation-where-are-we-a-comprehensive-review-of-the-current-evidence
#9
Brian Camilleri, Julie M Bridson, Ahmed Halawa
The introduction of the calcineurin inhibitors cyclosporine and tacrolimus in the immunosuppressive regimens for kidney transplant has been associated with substantial reductions in the incidence of acute rejection, with a subsequent improvement in 1-year graft survival. However, this has not directly correlated with improvements in long-term allograft survival. Immunosuppressive medications are associated with toxicities related directly to immunosuppressive effects, and these are similar among different agents...
May 17, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27210268/progress-and-challenges-for-treating-type-1-diabetes
#10
REVIEW
Justin W Garyu, Eric Meffre, Chris Cotsapas, Kevan C Herold
It has been more than 30 years since the initial trials of Cyclosporin A to treat patients with new onset Type 1 diabetes (T1D). Since that time, there have been insights into genetic predisposition to the disease, the failures of immune tolerance, and mechanisms that cause the immune mediated β cell destruction. The genetic loci associated affect lymphocyte development and tolerance mechanisms. Discoveries related to the roles of specific immune responses gene such as the major histocompatibility complex, PTPN22, CTLA-4, IL-2RA, as well as the mechanisms of antigen presentation in the thymus have suggested ways in which autoreactivity may follow changes in the functions of these genes that are associated with risk...
July 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27071733/keratoconjunctivitis-sicca-exacerbation-in-a-dog-treated-with-systemic-atenolol
#11
G Barsotti, T Vezzosi
A 6-year-old, intact, male English cocker spaniel was referred for treatment of chronic conjunctivitis and unilateral keratitis. The dog was diagnosed with bilateral immune-mediated keratoconjunctivitis sicca, treated with topical cyclosporine 0·2% ointment and sodium hyaluronate eye drops and improved considerably. After 2 months, pulmonic stenosis was diagnosed, and the dog commenced treatment with oral atenolol; the ophthalmological disease worsened dramatically within a few days. The ophthalmic signs rapidly improved after discontinuation of atenolol, and there was bilateral complete remission after 3 weeks...
July 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27033197/paroxysmal-nocturnal-haemoglobinuria-from-the-prespective-of-paediatric-haematologists
#12
Fabio Timeus, Nicoletta Crescenzio, Luiselda Foglia, Alessandra Doria, Paola Saracco
Paroxysmal nocturnal haemoglobinuria (PNH) is very rare in children. The review of the literature shows some peculiarities of paediatric age: high incidence of bone marrow failure at diagnosis, dark urines uncommon, diagnosis often delayed. The thrombosis incidence is variable in the different reports, but in general lower than in adults. The presence of glycosil phosphatidyl-inositol (GPI)-negative populations in acquired aplastic anaemia (AA) at diagnosis has been correlated with a favourable response to immune-suppressive therapy (IST) in adults, whereas the literature data in children are discordant...
April 1, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27023693/patient-characteristics-health-care-resource-utilization-and-costs-associated-with-treatment-regimen-failure-with-biologics-in-the-treatment-of-psoriasis
#13
Shonda A Foster, Baojin Zhu, Jiaying Guo, Enkeleida Nikai, Clement Ojeh, William Malatestinic, Orin Goldblum, Lori J Kornberg, Jashin J Wu
BACKGROUND: Psoriasis is a chronic, incurable, and immune-mediated skin disorder that is characterized by erythematous scaly papules and plaques. Understanding of psoriasis at the molecular level has led to the development of biologic agents that target disease-specific inflammatory mediators in psoriatic lesions. Biologic agents have become important components of the psoriasis armamentarium, but some patients become refractory to these agents over time or fail to respond to subsequent biologics...
April 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27000539/inhibition-of-bile-salt-transport-by-drugs-associated-with-liver-injury-in-primary-hepatocytes-from-human-monkey-dog-rat-and-mouse
#14
Jie Zhang, Kan He, Lining Cai, Yu-Chuan Chen, Yifan Yang, Qin Shi, Thomas F Woolf, Weigong Ge, Lei Guo, Jürgen Borlak, Weida Tong
Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of bile salts from their precursors in primary human, monkey, dog, rat, and mouse hepatocytes in suspension as well as LC-MS/MS determination of extracellular bile salts transported out of hepatocytes. Glycine- and taurine-conjugated bile acids were rapidly formed in hepatocytes and effectively transported into the extracellular medium...
August 5, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26975192/cyclosporine-a-induced-histological-changes-of-cathepsin-l-and-cd2ap-expression-in-renal-glomeruli-and-tubules
#15
Keisuke Sugimoto, Tomoki Miyazawa, Takuji Enya, Kouhei Miyazaki, Mitsuru Okada, Tsukasa Takemura
BACKGROUND: Cyclosporine A (CsA) is used globally as an immunosuppressant for the treatment of immune-mediated nephrotic syndrome (NS). However, its long-term use causes nephrotoxicity characterized by tubulointerstitial injury and glomerulosclerosis. The present study aimed to investigate the associations between histomorphological findings and immunohistological expression of Cathepsin L (CatL) and CD2-associated protein (CD2AP) in patients with NS mediated with CsA. METHODS: A total of 18 patients with child-onset NS were divided into two groups after treatment with CsA for 2 years (group A; n = 10) and more than 4 years (group B; n = 8), respectively...
March 14, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26845209/-use-of-rituximab-in-primary-and-secondary-glomerulonephritis
#16
Monica Insalaco, Luca Zanoli, Pasquale Fatuzzo, Fulvio Fiorini, Antonio Granata
Primary and secondary glomerulonephritis are a heterogeneous group of disorders characterized by "glomerular inflammation" with an immune-mediated pathogenesis. Considering the severe side effects of the immunosuppressive drugs, the therapeutic approach remains a challenge for the nephrologists. Corticosteroids, cytotoxic agents such as cyclophosphamide, or calcineurin inhibitors such as cyclosporine and tacrolimus, azathioprine and mycophenolate mofetil can all be used for the treatment of glomerulonephritis...
November 2015: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26845207/-management-of-antirheumatic-drugs-in-kidney-failure
#17
Rocco Manganelli, Serena Manganelli, Salvatore Iannaccone, Walter De Simone
The nephrologist deals with the management of patients with rheumatic disease, both diagnostically and therapeutically. He must determine whether the renal pathology is related to the rheumatologic disease, mostly through the use of the renal biopsy. In the second case, he must know the nephrotoxic potential of the drugs prescribed and adjust their use to the degree of renal impairment. This task is made difficult by the absence of controlled clinical trials regarding their use on patients with renal insufficiency or on chronic dialysis...
November 2015: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26829271/comparison-of-the-efficacy-of-prednisone-and-cyclosporine-for-treatment-of-dogs-with-primary-immune-mediated-polyarthritis
#18
Amy C Rhoades, William Vernau, Philip H Kass, Melissa A Herrera, Jane E Sykes
OBJECTIVE: To compare efficacy between cyclosporine and prednisone for treatment of primary immune-mediated polyarthritis (IMPA) in dogs. DESIGN: Randomized controlled clinical trial. ANIMALS: 20 client-owned dogs with primary IMPA. PROCEDURES: Dogs were randomly assigned to receive prednisone (starting at 1 mg/kg [0.45 mg/lb], PO, q 12 h; n = 10) or cyclosporine (5 mg/kg [2.3 mg/lb], PO, q 12 h; 10) for 90 days. Cyclosporine-treated dogs also received carprofen, tramadol, or both for the first 7 days for analgesia...
February 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/26771550/cyclosporine-for-dry-eye-associated-with-nivolumab-a-case-progressing-to-corneal-perforation
#19
Alexander T Nguyen, Maxwell Elia, Miguel A Materin, Mario Sznol, Jessica Chow
PURPOSE: To present the clinical outcome of 2 cases of severe dry eye associated with Nivolumab, with 1 case progressing to corneal perforation. DESIGN: Case report. CASE 1: : A 58-year-old man with metastatic melanoma was referred for the management of severe bilateral dry eyes after undergoing his sixth cycle of Nivolumab. The right eye progressed to corneal perforation 4 weeks after referral, after which Nivolumab was discontinued. When metastatic disease recurred, Nivolumab was continued with an ocular surface stabilized with an intensive regimen that included topical cyclosporine...
March 2016: Cornea
https://www.readbyqxmd.com/read/26730206/prevalence-of-acute-and-chronic-viral-seropositivity-and-characteristics-of-disease-in-patients-with-psoriatic-arthritis-treated-with-cyclosporine-a-post-hoc-analysis-from-a-sex-point-of-view-on-the-observational-study-of-infectious-events-in-psoriasis-complicated
#20
Delia Colombo, Sergio Chimenti, Paolo Antonio Grossi, Antonio Marchesoni, Federico Bardazzi, Fabio Ayala, Lucia Simoni, Donatella Vassellatti, Gilberto Bellia
BACKGROUND: Sex medicine studies have shown that there are sex differences with regard to disease characteristics in immune-mediated inflammatory diseases, including psoriasis, in immune response and susceptibility to viral infections. We performed a post hoc analysis of the Observational Study of infectious events in psoriasis complicated by active psoriatic arthritis (SYNERGY) study in patients with psoriatic arthritis (PsA) treated with immunosuppressive regimens including cyclosporine, in order to evaluate potential between-sex differences in severity of disease and prevalence of viral infections...
2016: Clinical, Cosmetic and Investigational Dermatology
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