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ssri bipolar

Andreas J Forstner, Stefanie Rambau, Nina Friedrich, Kerstin U Ludwig, Anne C Böhmer, Elisabeth Mangold, Anna Maaser, Timo Hess, Alexandra Kleiman, Antje Bittner, Markus M Nöthen, Jessica Becker, Franziska Geiser, Johannes Schumacher, Rupert Conrad
OBJECTIVES: Social anxiety disorder (SAD) is a common and heritable psychiatric disorder. However, genetic studies in SAD are rare and only a few candidate genes have been implicated so far. In the present study, we investigated whether single-nucleotide polymorphisms (SNPs) associated with other psychiatric disorders also contribute toward the development of SAD and followed up variants associated with SAD on the phenotypic level. PATIENTS AND METHODS: We genotyped a total of 24 SNPs in a German sample of 321 SAD patients and 804 controls...
March 7, 2017: Psychiatric Genetics
Firoz Kazhungil, E Mohandas
Obsessive-compulsive disorder (OCD) is one of the most common comorbidities in bipolar disorder (BD). Clinicians often get perplexed in making treatment decisions when encountering comorbid OCD and BD as treatment of OCD by pharmacotherapy may induce or exacerbate mood instability and psychotherapeutic approaches for OCD may not be feasible in acute manic or depressive state of BD. In this study, we reviewed literature, whether existing guideline-based treatments of BD may be effective in OCD and whether newer agents will be of use for treating this comorbidity...
July 2016: Indian Journal of Psychiatry
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Robert J DeRubeis
OBJECTIVE: This study examined the relationship between the number of prior antidepressant treatment trials and step-wise increase in pharmacodynamic tolerance (or progressive loss of effectiveness) in subjects with bipolar II depression. METHODS: Subjects ≥18 years old with bipolar II depression (n=129) were randomized to double-blind venlafaxine or lithium carbonate monotherapy for 12 weeks. Responders (n=59) received continuation monotherapy for six additional months...
November 2016: Bipolar Disorders
Katrine Kveli Fjukstad, Anne Engum, Stian Lydersen, Ingrid Dieset, Nils Eiel Steen, Ole A Andreassen, Olav Spigset
OBJECTIVE: The aim of the present study was to examine the effect of selective serotonin reuptake inhibitors (SSRIs) on cardiovascular risk factors in patients with schizophrenia or bipolar disorder. METHOD: We used data from a cross-sectional study on 1301 patients with schizophrenia or bipolar disorder, of whom 280 were treated with SSRIs. The primary outcome variable was the serum concentration of total cholesterol. Secondary outcome variables were low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol, triglyceride and glucose levels, body mass index, waist circumference, and systolic and diastolic blood pressure...
December 2016: Journal of Clinical Psychopharmacology
Stephen Hogg, Sereena Ansari, Qasim Masood, Mark Agius, Zoltan Rihmer
Concerns have recently been raised about a possible link between suicidal ideation and the use of SSRIs in teenagers diagnosed with unipolar depression, such that the USA FDA and UK CSM have issued warnings regarding the use of SSRIs in adolescents with depression. We investigated this phenomenon first by recognizing that the initial presentation of unipolar and bipolar depression may only differ in subtle ways and with the result being that a significant number of patients are misdiagnosed at the expense of patient outcomes...
September 2016: Psychiatria Danubina
Amir Hossein Mirhashemi, Mohammad Sadegh Ahmad Akhoundi, Sedigheh Sheikhzadeh, Nafiseh Momeni, Ahmadreza Dehpour, Mojgan Alaeddini, Yasaman Kheirandish, Homa Farhadifard, Elahe Ansari
OBJECTIVES: Fluoxetine is a selective serotonin re-uptake inhibitor (SSRI) widely used for depression, bipolar disorder, anxiety and obsessive-compulsive disorder. The aim of this study was to assess the effect of fluoxetine on orthodontic tooth movement (OTM) in rats. MATERIALS AND METHODS: Forty-five male Wistar rats were randomly divided into three groups namely the control group (no medication), saline and fluoxetine dissolved in saline. In all groups, nickel titanium closed-coil spring was used between the left maxillary central incisor and first molar to exert 60g force at 2mm activation...
December 2015: Journal of Dentistry of Tehran University of Medical Sciences
Leila Mnif, Rim Sellami, Jawaher Masmoudi
INTRODUCTION: Post-stroke emotional incontinence and bipolar disorder are two disorders that involve the dysfunction of brain structures responsible for emotional regulation. The objective of this work is to study the links between these disorders through a clinical case. CASE REPORT: We present the case of a 43-year-old man without previous psychiatric history who experienced emotional incontinence after cerebrovascular events. He reacted promptly to selective serotonin reuptake inhibitor treatment...
2016: Neuropsychiatric Disease and Treatment
Christina M Hough, F Saverio Bersani, Synthia H Mellon, Elissa S Epel, Victor I Reus, Daniel Lindqvist, Jue Lin, Laura Mahan, Rebecca Rosser, Heather Burke, John Coetzee, J Craig Nelson, Elizabeth H Blackburn, Owen M Wolkowitz
Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression severity (using the Hamilton Depression Rating Scale [HDRS]), and self-reported positive and negative affect in 27 healthy, unmedicated adults with MDD...
July 2016: Molecular Neuropsychiatry
D Bailly
OBJECTIVE: To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents. METHODS: A comprehensive literature review of randomized clinical trials and open-label studies was conducted. RESULTS: Published data from randomized controlled trials show that antipsychotics are significantly more effective than mood stabilizers in the treatment of manic or mixed episodes. Few data are available related to the treatment of depressive episodes...
May 16, 2016: L'Encéphale
Robert Langan, Andrew J Goodbred
Peripartum depression affects up to one in seven women and is associated with significant maternal and neonatal morbidity if untreated. A history of depression is the strongest risk factor for developing peripartum depression. The U.S. Preventive Services Task Force recommends screening pregnant and postpartum women for depression. Both two-step and one-step screening strategies are effective in identifying peripartum depression. Peripartum depression should be distinguished from the baby blues, which is characterized by short duration, mild symptoms, and minimal impact on functioning...
May 15, 2016: American Family Physician
Ling Zhang, Yun Chen, Li Yue, Qingjing Liu, William Montgomery, Lihua Zhi, Wanqi Wang
OBJECTIVE: The objective of the study was to investigate medication usage patterns, health care resource utilization, and direct medical costs of patients with major depressive disorder (MDD) in Beijing, People's Republic of China. METHODS: Data were extracted from a random sample of the Beijing Urban Employee Basic Medical Insurance database. Patients aged ≥18 years, with ≥1 primary diagnosis of MDD and 12-month continuous enrollment after their first observed MDD diagnosis between 2012 and 2013 were identified...
2016: Neuropsychiatric Disease and Treatment
Lisa L Giles, D Richard Martini
Most prescriptions for psychotropic medications are written by primary care physicians, yet pediatricians, many of whom are teaching residents and medical students about pediatric psychopharmacology, often feel inadequately trained to treat mental health concerns. Over the past several decades, the number, size, and quality of psychopharmacologic studies in youth has greatly increased. Here we review the current evidence for efficacy and safety of each of the major pharmacologic drug classes in youth (psychostimulants, antidepressants, mood stabilizers, and antipsychotics)...
August 2016: Academic Pediatrics
Alejandro Szmulewicz, Cecilia Samamé, Pablo Caravotta, Diego J Martino, Ana Igoa, Diego Hidalgo-Mazzei, Francesc Colom, Sergio A Strejilevich
BACKGROUND: Behavioral and emotional adverse events induced by drugs commonly prescribed to patients with bipolar disorders are of paramount importance to clinical practice and research. However, no reviews on the topic have been published so far. METHODS: An extensive search was performed. Reports were reviewed if they described behavioral side effects related to pharmacological treatments for bipolar disorders in healthy subjects or patients with different neuropsychiatric disorders...
December 2016: International Journal of Bipolar Disorders
Santiago Sánchez-Iglesias, Virginia García-Solaesa, Belén García-Berrocal, Almudena Sanchez-Martín, Carolina Lorenzo-Romo, Tomás Martín-Pinto, Andrea Gaedigk, José Manuel González-Buitrago, María Isidoro-García
One of the main concerns in psychiatric care is safety related to drug management. Pharmacogenetics provides an important tool to assess causes that may have contributed the adverse events during psychiatric therapy. This study illustrates the potential of pharmacogenetics to identify those patients for which pharmacogenetic-guided therapy could be appropriate. It aimed to investigate CYP2D6 genotype in our psychiatric population to assess the value of introducing pharmacogenetics as a primary improvement for predicting side effects...
February 2016: Medicine (Baltimore)
Joshua Shapiro, Sean Mindra, Vanessa Timmins, Brenda Swampillai, Antonette Scavone, Katelyn Collinger, Jordan Collins, Benjamin I Goldstein
OBJECTIVE: Despite numerous studies regarding obesity (OB) in adult bipolar disorder (BP), there are few studies on this topic among adolescents. The current study attempts to extend the literature on prevalence and correlates of OB in adolescent BP by including control participants, and determining OB by direct measurement. METHODS: Participants were 75 treatment-seeking adolescents, ages 13-19 years, with BP-I, -II, or -not otherwise specified, and 47 adolescents without major psychiatric illness...
February 2017: Journal of Child and Adolescent Psychopharmacology
Rashmi Patel, Peter Reiss, Hitesh Shetty, Matthew Broadbent, Robert Stewart, Philip McGuire, Matthew Taylor
OBJECTIVES: To investigate the association between antidepressant therapy and the later onset of mania/bipolar disorder. DESIGN: Retrospective cohort study using an anonymised electronic health record case register. SETTING: South London and Maudsley National Health Service (NHS) Trust (SLaM), a large provider of inpatient and community mental healthcare in the UK. PARTICIPANTS: 21,012 adults presenting to SLaM between 1 April 2006 and 31 March 2013 with unipolar depression...
December 14, 2015: BMJ Open
Chia-Ming Chang, Chi-Shin Wu, Ya-Wen Huang, Yeuk-Lun Chau, Hui-Ju Tsai
OBJECTIVE: The aim of the study was to examine utilization and patterns of psychopharmacological treatment during a 1-year follow-up period among patients with newly diagnosed bipolar disorder from 2001 to 2010. METHODS: Patients with newly diagnosed bipolar disorder from 2001 to 2010 were identified from the National Health Insurance Research Database in Taiwan. We assessed prescription records related to 4 kinds of psychopharmacological medication, including antipsychotics (APs), antidepressants, mood stabilizers, and benzodiazepines, as well as health care utilization in a 1-year follow-up period among the study subjects...
February 2016: Journal of Clinical Psychopharmacology
Andy R Eugene, Jolanta Masiak, Marek Masiak, Jacek Kapica
INTRODUCTION: The purpose of this investigatory neuroimaging analysis was done to better understand the pharmacodynamics of Lithium by isolating the norepinephrine pathway in the brain. To accomplish this, we compared patients with Bipolar Disorder treated with Lithium to patients diagnosed with Major Depression or Depressive Disorder who are treated with Selective Serotonin Reuptake Inhibitors (SSRIs). METHODOLOGY: We used Standardized Low Resolution Brain Electrotomography to calculate the whole brain, voxel-by-voxel, unpaired t-tests Statistical non-Parametric Maps...
December 2014: Brain: Broad Research in Artificial Intelligence and Neuroscience
Antonio Tundo, Rocco de Filippis, Luca Proietti
AIM: To review evidence supporting pharmacological treatments for treatment-resistant depression (TRD) and to discuss them according to personal clinical experience. METHODS: Original studies, clinical trials, systematic reviews, and meta-analyses addressing pharmacological treatment for TRD in adult patients published from 1990 to 2013 were identified by data base queries (PubMed, Google Scholar e Quertle Searches) using terms: "treatment resistant depression", "treatment refractory depression", "partial response depression", "non responder depression", "optimization strategy", "switching strategy", "combination strategy", "augmentation strategy", selective serotonin reuptake inhibitors antidepressants (SSRI), tricyclic antidepressants (TCA), serotonin norepinephrine reuptake inhibitors antidepressants, mirtazapine, mianserine, bupropione, monoamine oxidase inhibitor antidepressant (MAOI), lithium, thyroid hormones, second generation antipsychotics (SGA), dopamine agonists, lamotrigine, psychostimulants, dextromethorphan, dextrorphan, ketamine, omega-3 fatty acids, S-adenosil-L-metionine, methylfolat, pindolol, sex steroids, glucocorticoid agents...
September 22, 2015: World Journal of Psychiatry
Krzysztof Krysta, Sławomir Murawiec, Anna Warchala, Karolina Zawada, Wiesław J Cubała, Mariusz S Wiglusz, Katarzyna Jakuszkowiak-Wojten, Marek Krzystanek, Irena Krupka-Matuszczyk
Opipramol is considered as a pharmacological agent that does not fit the classification taking into account the division of antidepressants, antipsychotics and anxiolytics. It has a structure related to tricyclic antidepressants but it has a different mechanism of action, i.e. binding to sigma1 and to sigma2 sites. It has been regarded as an effective drug in general anxiety disorders together with other agents like SSRI`s, SNRI`s, buspirone and pregabalin for many years. It can however also be indicated in other conditions, e...
September 2015: Psychiatria Danubina
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