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Hyponatremia

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https://www.readbyqxmd.com/read/28087091/effect-of-single-dose-of-tolvaptan-in-neurocritical-patients-with-hyponatremia-due-to-syndrome-of-inappropriate-antidiuretic-hormone-secretion
#1
J A Llompart-Pou, J Pérez-Bárcena, M Novo, J M Raurich
No abstract text is available yet for this article.
January 10, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28078393/antipsychotic-use-is-a-risk-factor-for-hyponatremia-in-patients-with-schizophrenia-a-15-year-follow-up-study
#2
Hang-Ju Yang, Wan-Ju Cheng
RATIONALE: Hyponatremia affects 10% of patients with chronic schizophrenia and can lead to severe consequences. However, the role of antipsychotics and other risk factors in hyponatremia occurrence has remained inconsistent. OBJECTIVE: This study examined the association between antipsychotic use and hyponatremia occurrence in patients with schizophrenia. METHODS: We utilized the National Health Insurance Research Database to follow 2051 patients with schizophrenia from 1998 to 2013...
January 11, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28076863/adverse-renal-effects-of-immune-checkpoint-inhibitors-a-narrative-review
#3
Rimda Wanchoo, Sabine Karam, Nupur N Uppal, Valerie S Barta, Gilbert Deray, Craig Devoe, Vincent Launay-Vacher, Kenar D Jhaveri
BACKGROUND: Cancer immunotherapy, such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death 1 (PD-1), has revolutionized the treatment of malignancies by engaging the patient's own immune system against the tumor rather than targeting the cancer directly. These therapies have demonstrated a significant benefit in the treatment of melanomas and other cancers. SUMMARY: In order to provide an extensive overview of the renal toxicities induced by these agents, a Medline search was conducted of published literature related to ipilimumab-, pembrolizumab-, and nivolumab-induced kidney toxicity...
January 12, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28074251/hyponatremia-and-fractures-should-hyponatremia-be-further-studied-as-a-potential-biochemical-risk-factor-to-be-included-in-frax-algorithms
#4
REVIEW
J C Ayus, T Bellido, A L Negri
The Fracture Risk Assessment Tool (FRAX®) was developed by the WHO Collaborating Centre for metabolic bone diseases to evaluate fracture risk of patients. It is based on patient models that integrate the risk associated with clinical variables and bone mineral density (BMD) at the femoral neck. The clinical risk factors included in FRAX were chosen to include only well-established and independent variables related to skeletal fracture risk. The FRAX tool has acquired worldwide acceptance despite having several limitations...
January 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28072747/the-clinical-characteristics-and-short-term-prognosis-in-elderly-patients-with-guillain-barr%C3%A3-syndrome
#5
Bing Zhang, Xiujuan Wu, Donghui Shen, Ting Li, Chunrong Li, Mei Mao, Hong-Liang Zhang, Kangding Liu
To investigate the clinical characteristics and short-term prognosis of elderly patients with Guillain-Barré syndrome (GBS).We retrospectively analyzed the clinical data of adult GBS. According to the age, the enrolled subjects were divided into 2 groups, that is, patients ≥60 years (elderly group) and those aged 18 to 59 years (nonelderly group). The clinical characteristics and short-term prognosis of the patients in the 2 groups were compared.In total, 535 patients were enrolled. There were 67 patients fell into the elderly group with a mean age of 69 years old; while 468 patients fell into the nonelderly group with a mean age of 39 years old...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072685/nephrotic-syndrome-associated-with-metastatic-thymoma-treated-with-chemotherapy
#6
Shin Hye Yoo, Hyean-Ji Kim, Jeong-Han Kim, Gyeong-Won Lee, Jeong Hee Lee, Se Hyun Kim, Ji-Won Kim, Jin Won Kim, Jeong-Ok Lee, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Jong Seok Lee
RATIONALE: Nephropathy with concurrent invasive thymoma is a type of paraneoplastic syndrome. PATIENT CONCERNS AND DIAGNOSES: We report a 32-year-old female with nephrotic syndrome that was first diagnosed along with invasive thymoma and treated by means of cisplatin-based chemotherapy for the thymoma. The patient initially presented with dyspnea and generalized edema. Chest radiography and computed tomography scans revealed right pleural effusion and a mass in the right middle lung field, which were confirmed by a percutaneous lung biopsy as metastatic invasive thymoma...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070473/renal-infiltration-by-diffuse-large-b-cell-lymphoma-as-a-rare-cause-of-fanconi-s-syndrome-a-case-report
#7
Shoab Saadat, Syed Nayer Mahmud, Asim Qureshi
We report the case of a 16-year-old female patient with a known history of coeliac disease, who presented with the complaints of diarrhea, vomiting and generalized body weakness. On examination, she was found to have dehydration, decreased power in all her limbs, cervical lymphadenopathy and hepatosplenomegaly. Investigations showed severe hypokalemia, hyponatremia, hypomagnesemia, hypoglycemia and mildly enlarged kidneys on ultrasonography. Biopsy of the duodenum confirmed the flare up of coeliac disease, while cervical lymph node biopsy was positive for atypical lymphoid infiltrate and a morphology suggestive of non-Hodgkin's lymphoma...
November 30, 2016: Curēus
https://www.readbyqxmd.com/read/28070057/hyponatremia-can-be-a-powerful-predictor-of-the-development-of-isolated-acth-deficiency-associated-with-nivolumab-treatment-letter-to-the-editor
#8
Kyu Yong Cho, Hideaki Miyoshi, Akinobu Nakamura, Takashi Kurita, Tatsuya Atsumi
No abstract text is available yet for this article.
January 6, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28060134/severe-hyponatremia-in-a-single-center-series-of-84-homogenously-treated-children-with-acute-lymphoblastic-leukemia
#9
Szymon Janczar, Beata Zalewska-Szewczyk, Wojciech Mlynarski
Electrolyte abnormalities are hallmark metabolic disturbances during the treatment of acute lymphoblastic leukemia (ALL). Hyponatremia is an ominous laboratory sign in the setting of neoplasia. We analyzed the incidence, risk factors, associations, specific interventions and outcomes of severe hyponatremia in a single-center series of children with ALL. The incidence of severe hyponatremia, defined as serum sodium levels below 130 mmol/L on at least 2 of 3 consecutive days, was 11.9%. History of hyponatremia episode is associated with neurologic complications (P=0...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28058990/restoration-of-the-response-of-the-middle-cerebral-artery-of-the-rat-to-acidosis-in-hyposmotic-hyponatremia-by-the-opener-of-large-conductance-calcium-sensitive-potassium-channels-bkca
#10
Marta Aleksandrowicz, Beata Dworakowska, Krzysztof Dolowy, Ewa Kozniewska
Hyposmotic hyponatremia (the decrease of extracellular concentration of sodium ions from 145 to 121 mM and the decrease of hyposmolality from 300 to 250 mOsm/kg H2O) impairs response of the middle cerebral artery (MCA) to acetylcholine and NO donor (S-nitroso-N-acetyl-DL-penicillamine). Since acidosis activates a similar intracellular signaling pathway, the present study was designed to verify the hypothesis that the response of the MCA to acidosis is impaired during acute hyposmotic hyponatremia due to abnormal NO-related signal transduction in vascular smooth muscle cells...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28054290/treatment-of-hyponatremia-in-patients-with-acute-neurological-injury
#11
Theresa Human, Aaron M Cook, Brian Anger, Kathleen Bledsoe, Amber Castle, David Deen, Haley Gibbs, Christine Lesch, Norah Liang, Karen McAllen, Christopher Morrison, Dennis Parker, A Shaun Rowe, Denise Rhoney, Kiranpal Sangha, Elena Santayana, Scott Taylor, Eljim Tesoro, Gretchen Brophy
BACKGROUND: Little data exist regarding the practice of sodium management in acute neurologically injured patients. This study describes the practice variations, thresholds for treatment, and effectiveness of treatment in this population. METHODS: This retrospective, multicenter, observational study identified 400 ICU patients, from 17 centers, admitted for ≥48 h with subarachnoid hemorrhage (SAH), traumatic brain injury (TBI), intraparenchymal hemorrhage, or intracranial tumors between January 1, 2011 and July 31, 2012...
January 4, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28051801/%C3%A2-utility-and-safety-of-tolvaptan-in-cirrhotic-patients-with-hyponatremia-a-prospective-cohort-study
#12
Ji-Dong Jia, Wen Xie, Hui-Guo Ding, Hua Mao, Yonggang Li, Xiaojin Wang, Jie-Fei Wang, Wei Lu, Cheng-Zhong Li, Yimin Mao, Gui-Qiang Wang, Yue-Qiu Gao, Bangmao Wang, Qin Zhang, Yan Ge, Vincent Wai-Sun Wong
:  Introduction and aim. Hyponatremia is common in patients with decompensated cirrhosis and is associated with increased mortality. Tolvaptan, a vasopressor V2 receptor antagonist, can increase free water excretion, but its efficacy and safety in cirrhotic patients remain unclear. MATERIAL AND METHODS: We studied the usage and safety of tolvaptan in cirrhotic patients in a real-life, non-randomized, multicenter prospective cohort study. Forty-nine cirrhotic patients with hyponatremia were treated with tolvaptan 15 mg daily, and 48 patients not treated with tolvaptan in the same period served as controls...
January 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28049892/maintenance-of-clinical-expertise-and-clinical-research-by-the-clinical-professors-at-gifu-pharmaceutical-university
#13
Tomoya Tachi, Yoshihiro Noguchi, Hitomi Teramachi
 The clinical professors at Gifu Pharmaceutical University (GPU) provide pharmaceutical services at GPU Pharmacy, Gifu University Hospital, and Gifu Municipal Hospital to keep their clinical skills up-to-date; they also perform clinical research in collaboration with many clinical institutes. The Laboratory of Clinical Pharmacy is part of the Department of Pharmacy Practice and Science, to which the clinical professors belong, and is composed of three clinical professors (a professor, an associate professor, and an assistant professor)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28045849/treatment-of-severe-hypervolemic-hyponatremia-in-a-child-with-pneumonia
#14
Dimitri Poddighe
No abstract text is available yet for this article.
January 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28043062/pharmacokinetic-variability-efficacy-and-tolerability-of-eslicarbazepine-acetate-a-national-approach-to-the-evaluation-of-therapeutic-drug-monitoring-data-and-clinical-outcome
#15
Torleiv Svendsen, Eylert Brodtkorb, Arne Reimers, Espen Molden, Erik Sætre, Svein I Johannessen, Cecilie Johannessen Landmark
BACKGROUND: Eslicarbazepine acetate (ESL) is a new antiepileptic drug (AED), still insufficiently studied regarding pharmacokinetic variability, efficacy and tolerability. The purpose of this study was to evaluate therapeutic drug monitoring (TDM) data in Norway and relate pharmacokinetic variability to clinical efficacy and tolerability in a long-term clinical setting in patients with refractory epilepsy. METHODS: This retrospective observational study included TDM-data from the main laboratories and population data from the Norwegian Prescription Database in Norway, in addition to clinical data from medical records of adult patients using ESL for up to three years, whenever possible...
December 5, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28040989/n-terminal-pro-brain-natriuretic-peptide-concentrations-after-hypertensive-intracerebral-hemorrhage
#16
Fei Li, Qian-Xue Chen, Shou-Gui Xiang, Shi-Zhun Yuan, Xi-Zhen Xu
INTRODUCTION: The role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with hypertensive intracerebral hemorrhage (HICH) is poorly understood. This study aimed to investigate the secretion pattern of NT-proBNP in patients with HICH and to assess its relationship with hematoma size, hyponatremia, and intracranial pressure (ICP). METHODS: This prospective study enrolled 147 isolated patients with HICH. Blood samples were obtained from each patient, and values of serum NT-proBNP, hematoma size, blood sodium, and ICP were collected for each patient...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28039863/prevalence-of-autonomic-dysfunction-in-hospitalized-patients-with-guillain-barre-syndrome
#17
Charenya Anandan, Sadik A Khuder, Boyd M Koffman
INTRODUCTION: There is a paucity of data regarding autonomic dysfunction (AD) in Guillain-Barré Syndrome (GBS). Concern exists regarding inpatient mortality risk in GBS. We sought to identify the prevalence of AD in GBS inpatients. METHODS: We used the Health Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS). GBS hospitalizations were identified by ICD-9-CM code-357.0. Non-GBS hospitalizations were matched to these cases 4:1 by age and gender...
December 31, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/28039265/safety-tolerability-and-preliminary-activity-of-lb-100-an-inhibitor-of-protein-phosphatase-2a-in-patients-with-relapsed-solid-tumors
#18
John S Kovach, Vincent Chung, Aaron S Mansfield, Fadi Braiteh, Donald Richards, Henry Durivage, Richard S Ungerleider, Francis Johnson
PURPOSE: To determine the maximum tolerated dose and to assess the safety, tolerability, and potential activity of LB-100, a first-in-class small molecule inhibitor of protein phosphatase 2A (PP2A) in adult patients with progressive solid tumors. EXPERIMENTAL DESIGN: LB-100 was administered intravenously daily for 3 days in 21-day cycles in a 3+3 dose-escalation design. RESULTS: There were 29 patient entries over 7 dose escalations. One patient stopped treatment after one dose because of an acute infection and was re-enrolled after recovery; each course was analyzed as a separate patient entry...
December 30, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28033281/correlation-of-baseline-hormonal-disorders-with-immunological-failure-and-mortality-in-male-hiv-patients-during-follow-up
#19
Ying Wen, Hai Bo Ding, Wei Chen, Ying Zhou, Wen Wang, Yu Wang, Xu Lu, Jing Liu, Jing Kang, Wenqing Geng, Hong Shang, Pei Liu
To assess the effect that hormonal disturbances have on HIV prognosis in male patients. A prospective follow-up study was conducted among male HIV patients who started antiretroviral therapy (ART) between July 1, 2011 and June 30, 2014. The final follow-up session occurred before December 31, 2014. We examined the correlation between pre-ART hormone levels and disease prognosis. The Kaplan-Meier method and the multivariate Cox proportional hazard model were used to identify hormone-related predictors of immunological failure and mortality...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28029447/a-phase-ii-evaluation-of-ixabepilone-in-the-treatment-of-recurrent-persistent-carcinosarcoma-of-the-uterus-an-nrg-oncology-gynecologic-oncology-group-study
#20
Carolyn K McCourt, Wei Deng, Don S Dizon, Heather A Lankes, Michael J Birrer, Michele M Lomme, Matthew A Powell, James E Kendrick, Joel N Saltzman, David Warshal, Meaghan E Tenney, David M Kushner, Carol Aghajanian
BACKGROUND: The primary objectives were to determine the objective response rate (ORR) and safety profile of ixabepilone in women with recurrent or persistent uterine carcinosarcoma (UCS). Secondary objectives included progression-free survival (PFS) and overall survival (OS). Exploratory translational objectives included characterization of class III beta tubulin expression and its association with response, PFS, and OS. METHODS: Patients had measurable disease; up to two prior chemotherapeutic regimens were allowed, but must have included a taxane...
October 28, 2016: Gynecologic Oncology
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