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Hyponatremia

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https://www.readbyqxmd.com/read/29775155/long-term-surgical-outcomes-following-transsphenoidal-surgery-in-patients-with-rathke-s-cleft-cysts
#1
Michelle Lin, Michelle A Wedemeyer, Daniel Bradley, Daniel A Donoho, Vance L Fredrickson, Martin H Weiss, John D Carmichael, Gabriel Zada
OBJECTIVE Rathke's cleft cysts (RCCs) are benign epithelial lesions of the sellar region typically treated via a transsphenoidal approach with cyst fenestration and drainage. At present, there is limited evidence to guide patient selection for operative treatment. Furthermore, there is minimal literature describing factors contributing to cyst recurrence. METHODS The authors conducted a retrospective analysis of 109 consecutive cases of pathology-confirmed RCCs treated via a transsphenoidal approach at a single center from 1995 to 2016...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29773358/-antidepressive-agents-and-hyponatremia-a-literature-review-and-a-case-non-case-study-in-the-french-pharmacovigilance-database
#2
Michaël Rochoy, Christina Zakhem-Stachera, Johana Béné, Christophe Berkhout, Sophie Gautier
OBJECTIVE: Most antidepressants have been associated with a risk of hyponatremia in the literature. This effect is not always reported in monographs. The aim of our study was to clarify the difference of increased risk of hyponatremia among various antidepressants. METHODS: Retrospective study of such cases/non-cases from observations recorded in the French national pharmacovigilance between 01/01/2004 and 31/12/2013. We studied all antidepressants marketed in 2014 in France, with a positive control (haloperidol) and a negative one (amoxicillin)...
March 1, 2018: Thérapie
https://www.readbyqxmd.com/read/29772226/potential-role-of-peroxisome-proliferator-activated-receptor-gamma-activation-on-serum-visfatin-and-trace-elements-in-high-fat-diet-induced-type-2-diabetes-mellitus
#3
Arshia Tabassum, Syeda Nuzhat Fatima Zaidi, Kausar Yasmeen, Tabassum Mahboob
AIMS: Electrolytes and trace elements dysregulation play an important role in the progression of obesity and diabetes complications. The present study was designed to evaluate the insulin sensitizing effects of peroxisomes proliferators activated receptor gamma (PPAR-γ) agonist on trace elements in obesity induced type 2 diabetes mellitus and correlate with serum visfatin. MATERIALS AND METHODS: Wistar rats were categorized into five groups. Group I served as control; Group II fed on high fat diet (HFD); Group III fed on HFD and treated with rosiglitazone (3 mg/kg) for 7 days; Group IV were T2DM rats induce by HFD and low dose of streptozotocin (i...
May 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29771702/pathogenesis-of-cerebral-edema-in-patients-with-acute-renal-and-liver-failure-and-the-role-of-the-nephrologist-in-the-management
#4
Tamim Hamdi
PURPOSE OF REVIEW: Acute liver failure (ALF) is a severe and complex illness and one of the most daunting conditions managed in the ICU. Because the renal care is intertwined with multiple disciplines, the aim of this review is to examine the multifactorial pathogenesis of cerebral edema in ALF, covering basic established facts as well as recent advances in our understanding of this condition. RECENT FINDINGS: Acetaminophen remains the most common cause of ALF in the United States and many European countries...
May 15, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29770976/pharmacokinetic-and-pharmacodynamic-properties-of-orally-administered-torsemide-in-healthy-horses
#5
Gustavo F Agne, Seung Woo Jung, Anne A Wooldridge, Susan H Duran, William Ravis, Ramiro Toribio
BACKGROUND: Diuretic treatment is the mainstay for management of congestive heart failure in horses, and its use has been restricted to injectable medications because no currently data supports the use of PO administered loop diuretics. OBJECTIVES: To determine the pharmacokinetic and pharmacodynamic properties of PO administered torsemide and, determine if PO administered torsemide, could be used as an alternative to injectable diuretics in the horse. ANIMALS: Six healthy adult mares...
May 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29770745/2706-km-cycling-in-two-weeks-effects-on-cardiac-function-in-six-elderly-male-athletes
#6
Thomas Morville, Mads Rosenkilde, Nick Mattsson, Flemming Dela, Jørn W Helge, Hanne K Rasmusen
INTRODUCTION: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion. METHODS: We studied six elderly male athletes (61±8 years (mean ± SD); baseline VO2 max 48±5 ml·kg-1 · min-1 ) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km...
May 17, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29766284/sodium-levels-during-hospitalization-with-acute-myocardial-infarction-are-markers-of-in-hospital-mortality-soroka-acute-myocardial-infarction-ii-sami-ii-project
#7
Ygal Plakht, Harel Gilutz, Arthur Shiyovich
OBJECTIVE: Abnormalities in sodium homeostasis are common in hospitalized patients. Hyponatremia upon admission is a poor prognostic marker in acute myocardial infarction (AMI) patients. However, little is known about the association between changes in sodium levels and in-hospital mortality. We delineated changes in sodium levels and studied the association of such changes with in-hospital mortality of AMI patients. METHODS: Retrospective analysis of AMI patients hospitalized for > 6 days...
May 15, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29762233/adrenal-histoplasmosis
#8
Vanessa Sanders, Joseph Donald, Barry A Siegel
An 89-year-old woman presented with seizure and hyponatremia. CT and MRI demonstrated mass-like enlargement of the adrenal glands and multiple pulmonary nodules. PET/CT performed to evaluate for metastatic disease demonstrated intense 18F-FDG uptake within enlarged adrenal glands. Given mild uptake in the pulmonary nodules, the differential diagnosis for the adrenal uptake included lymphoma, granulomatous infection, and less likely, metastatic lung cancer.
May 14, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29750929/hyponatremia-predicts-poor-outcomes-in-patients-with-chronic-kidney-disease-undergoing-heart-surgery
#9
Linda Shavit, Ofer Merin, Tal Grenader, Ehud Jacobson, Chani Waldenberg, Daniel Bitran, Daniel Fink, Shuli Silberman
BACKGROUND: Preoperative hyponatremia adversely impacts outcomes of cardiothoracic surgery. However, in patients with chronic kidney disease, the association of sodium levels on postoperative events has never been evaluated. We investigated the impact of preoperative hyponatremia on outcomes after cardiac surgery in patients with non-dialysis-dependent chronic kidney disease. Primary endpoints were operative mortality and acute kidney injury requiring dialysis. Secondary endpoints were major infection and long-term survival...
May 8, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29748094/what-s-new-in-aquablation
#10
REVIEW
Richard Lee, Claus Roehrborn
Transurethral resection of the prostate (TURP) is considered the gold standard for minimally invasive treatment of lower urinary tract symptoms due to benign prostate enlargement of <80ml. Although durable and effective, TURP carries the risk of significant side effects, including infection and bleeding, and the risk of dilutional hyponatremia. The Aquabeam system uses high-velocity water jets to robotically ablate prostatic tissue under real-time ultrasound guidance, with hemostasis achieved via a catheter balloon tamponade and a novel traction device or electrocautery...
May 7, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29742372/case-14-2018-a-68-year-old-woman-with-a-rash-hyponatremia-and-uveitis
#11
Molly L Paras, Emily P Hyle, Ruth K Foreman, K C Coffey
Presentation of Case. Dr. AbdulRasheed A. Alabi (Medicine): A 68-year-old woman was admitted to this hospital during the winter because of a rash, hyponatremia, and anterior uveitis. One month before admission, the patient traveled abroad. She spent a week in Sweden visiting family members,..
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29730273/differences-in-associations-of-antiepileptic-drugs-and-hospitalization-due-to-hyponatremia-a-population-based-case-control-study
#12
Henrik Falhammar, Jonatan D Lindh, Jan Calissendorff, Shermineh Farmand, Jakob Skov, David Nathanson, Buster Mannheimer
PURPOSE: Hyponatremia induced by antiepileptic drugs is common, but detailed evidence is lacking. This can be problematic for the treating neurologist confronted with a patient with severe hyponatremia in need of an alternative drug. The objective of this study was to examine the association between individual antiepileptic drugs and hospitalization due to hyponatremia. METHODS: This was a register-based case-control study of patients in the general Swedish population...
April 30, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29726784/association-of-copeptin-a-surrogate-marker-of-arginine-vasopressin-with-cerebral-vasospasm-and-delayed-ischemic-neurologic-deficit-after-aneurysmal-subarachnoid-hemorrhage
#13
Sandra J Fernandez, Ibraham Barakat, James Ziogas, Tony Frugier, Stanley S Stylli, John D Laidlaw, Andrew H Kaye, Alexios A Adamides
OBJECTIVE Delayed ischemic neurological deficit (DIND) is a leading cause of mortality and morbidity after aneurysmal subarachnoid hemorrhage (aSAH). Arginine vasopressin (AVP) is a hormone released by the posterior pituitary. It is known to cause cerebral vasoconstriction and has been implicated in hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion. Direct measurement of AVP is limited by its short half-life. Copeptin, a cleavage product of the AVP precursor protein, was therefore used as a surrogate marker for AVP...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29722659/tolerability-of-adxs11-001-lm-llo-listeria-based-immunotherapy-with-mitomycin-fluorouracil-and-radiation-for-anal-cancer
#14
Howard Safran, Kara-Lynne Leonard, Kimberly Perez, Matthew Vrees, Adam Klipfel, Steven Schechter, Nicklas Oldenburg, Leslie Roth, Nishit Shah, Kayla Rosati, Lakshmi Rajdev, Kalyan Mantripragada, Iris Y Sheng, Peter Barth, Thomas A DiPetrillo
PURPOSE: To obtain safety and preliminary efficacy data of the combination of ADXS11-001, live attenuated Listeria monocytogenes bacterium, with mitomycin, 5-fluorouracil (5-FU), and intensity modulated radiation therapy in locally advanced anal cancer. PATIENTS AND METHODS: Eligibility included patients with previously untreated, nonmetastatic anal cancer with a primary tumor >4 cm or node-positive disease. Patients received 2 cycles of mitomycin and 5-FU concurrent with 54...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29722489/-study-of-diagnostic-value-of-natremia-in-a-cohort-of-patients-with-hypercalcemia
#15
A Le, B Couturier, E Cogan, F Vandergheynst
INTRODUCTION: Hypercalcemia is a common pathological condition in clinical practice. The two most common causes are primary hyperparathyroidism and cancer. SIADH is often encountered in cancer cases and is the most common cause of hyponatremia. The aim of this study is to evaluate serum sodium levels in a cohort of patients with hypercalcemia and consider its predictive value in determining the origin of this hypercalcemia. MATERIALS AND METHODS: We performed a retrospective study on a series of 15...
2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29720096/celiac-crisis-a-rare-and-profound-presentation-of-celiac-disease-a-case-report
#16
Elizabeth Ann Forrest, Mark Wong, Srinivasa Nama, Siddharth Sharma
BACKGROUND: Celiac crisis is a life-threatening manifestation of celiac disease and is rare in adults, with only a handful of cases documented worldwide and mostly in children. CASE PRESENTATION: A profoundly emaciated 43-year-old female presented with profuse diarrhoea, shortness of breath, left leg swelling with ulceration and immobility (Body Mass Index (BMI) = 14.7 kg/m2 ). The patient had normal anion-gap metabolic acidosis (pH = 7.16) with persisting hypokalemia, hyponatremia, hypomagnesemia and hypophosphatemia...
May 2, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29709945/a-case-of-fulminant-type-1-diabetes-mellitus-complicated-with-a-life-threatening-electrolyte-abnormality-and-abnormal-electrocardiogram-findings
#17
Tomoe Kinoshita, Hideaki Kaneto, Fumiko Kawasaki, Takatoshi Anno, Takeyuki Kurihara, Haruki Yamada, Yoshiyuki Oshiro, Naoyuki Miyashita, Niro Okimoto, Kohei Kaku
Fulminant type 1 diabetes mellitus (T1DM) is idiopathic T1DM with the rapid destruction of pancreatic β-cells. We herein report a 48-year-old man who developed fulminant T1DM complicated with a life-threatening electrolyte abnormality and abnormal electrocardiogram findings. He had no remarkable medical history, but one day, he developed general fatigue. His blood glucose level and HbA1c were 806 mg/dL and 6.3%, and his insulin secretion was markedly suppressed. He had ketoacidosis, hyponatremia and hyperkalemia...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29707630/tacrolimus-induced-hyponatremia-in-lung-transplant-recipients-a-case-series
#18
Paul N Banks, Ashraf Omar, Rajat Walia, Sarabjit Bhalla, Yun Chong, Sofya Tokman
Background: Lung transplant recipients are treated with a 3-drug immunosuppressive regimen that consists of a calcineurin inhibitor, an antiproliferative agent, and a corticosteroid. Calcineurin inhibitors are the backbone of this regimen, and tacrolimus is used more often than cyclosporine, because tacrolimus is the more potent of the two agents. Tacrolimus-induced hyponatremia has been described among kidney transplant recipients, but not among lung transplant recipients. Methods: We conducted a retrospective chart review of patients who underwent lung transplant at our institution and went on to develop severe hyponatremia...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29703048/tolvaptan-rescue-contrast-induced-acute-kidney-injury-a-case-report
#19
Wei-Chieh Lee, Hsiu-Yu Fang, Chih-Yuan Fang
RATIONALE: Contrast-induced acute kidney injury is one of the most serious adverse effects of contrast media and is related to three distinct but interacting mechanisms: medullary ischemia, formation of reactive oxygen species and direct tubular cell toxicity, especially in the patients with chronic kidney disease. The strategies of treatment, including stabilization of hemodynamic parameters and maintenance of normal fluid and electrolyte balance, were similar to the management of other types of acute kidney injury...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29697294/express-is-hyponatremia-associated-with-mortality-in-pulmonary-arterial-hypertension
#20
Anastasiia A Rudkovskaia, Adriano Tonelli, Youlan Rao, Jeffrey P Hammel, Gregory K Buller, Raed A Dweik, Wassim H Fares
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
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