Read by QxMD icon Read

(Leukemia cutis) review

L Martínez-Leboráns, A M Victoria-Martínez, J L Torregrosa-Calatayud, V Alegre de Miquel
Dermatologic manifestations of leukemia can be both specific and nonspecific (e.g., opportunistic infections, purpura and ecchymosis, Sweet syndrome). Leukemia cutis refers to the infiltration of the skin with neoplastic leukocytes and its early diagnosis has important prognostic implications. We report on 17 cases of leukemia cutis seen in our department between 1994 and 2014 and describe the characteristics of the patients (age, sex, medical history), the morphology of the lesions, and associations with systemic disease...
May 19, 2016: Actas Dermo-sifiliográficas
Juan Pablo Castanedo-Cázares, Amalia Reyes-Herrera, Diana Hernández-Blanco, Cuauhtémoc Oros-Ovalle, Bertha Torres-Álvarez
Hypercalcemia in children with malignancy is an uncommon condition. It has been described in leukemia patients with impaired renal excretion of calcium or osteolytic lesions. Metastatic calcinosis cutis (MCC) may develop if hypercalcemia persists. We report the case of a 5-year-old girl with an atypical dermatosis and unspecific gastrointestinal symptoms. Considered clinical diagnoses were xanthomas, histiocytosis, molluscum contagiosum, and nongenital warts. Cutaneous histological analysis showed amorphous basophilic deposits in the dermis suggestive of calcium deposits...
2015: Case Reports in Hematology
M Schmid-Wendtner, T Hornung, M Meurer, C-M Wendtner
Numerous cutaneous manifestations have been reported in patients with hematologic malignancies. This review provides an overview on this subject by dividing skin lesions into three main groups: (1) skin disorders due to vascular changes (dilatation, occlusion and inflammation), (2) unspecific (e.g. paleness, opportunistic infections) and specific skin lesions (e.g. leukemia cutis), and (3) the large group of paraneoplastic skin disorders. Emphasis is placed on clinical findings and therapeutic options of those paraneoplastic syndromes that are most frequently found in hematologic malignancies...
August 2015: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Igor Altman, Ina H Lee, Matthew R Burns, Damiano Rondelli, William J Ennis
Calcinosis cutis is a poorly understood process in which calcium salts deposit in the skin and subcutaneous tissues. Due to its multifactorial pathogenesis, several subtypes and potential etiologies have been described. Presented here is a case of bilateral pretibial calcinosis cutis in a patient on long-term tyrosine kinase inhibitor therapy for chronic myeloid leukemia. The patient initially presented with a right tibial ulceration treated with multiple surgical debridements, antibiotics, and negative pressure wound therapy...
February 2015: Wounds: a Compendium of Clinical Research and Practice
Alejandro A Gru, Carrie C Coughlin, Melissa L Schapiro, Milan Lombardi, Ann Martin, Susan J Bayliss, John Frater, Louis P Dehner
Leukemia cutis (LC) denotes a cutaneous infiltration of neoplastic myeloid cells or lymphoid blasts, which can present in the setting of acute myeloid leukemia, particularly in those cases with monocytic or myelomonocytic differentiation. Rarely, cutaneous involvement by a leukemic infiltrate can occur in the absence of bone marrow or peripheral blood involvement by acute leukemia; this then is referred to as aleukemic LC (ALC). Recognition of LC is important for further classification and early diagnosis of the disease, but the diagnosis is difficult in the absence of a systemic presentation of acute leukemia...
June 2015: American Journal of Dermatopathology
Małgorzata Skórska
AIM: A literature review was undertaken to identify current TSEB therapy in pediatric patients. BACKGROUND: Total skin electron beam (TSEB) therapy is a method of irradiation with low energy electron beam dedicated to patients who have superficial skin lesions all over their body. Such skin malignancies are sparse among adults and even more uncommon with pediatric population. MATERIALS AND METHODS: In this study, all reported case reports were summed up with a special emphasis on techniques used, doses prescribed and special shielding of critical organs...
March 2014: Reports of Practical Oncology and Radiotherapy
Richard Bakst, Joachim Yahalom
PURPOSE: Leukemia cutis (LC) is the infiltration of the epidermis, dermis, or subcutis by neoplastic leukocytes, resulting in clinically identifiable cutaneous lesions. Electron-based radiation therapy (RT) is often used in the treatment of LC; however, modern studies of RT are lacking. We reviewed our experience to analyze treatment response, disease control, and toxicity associated with RT in order to develop treatment recommendations for patients with LC. METHODS AND MATERIALS: Fifteen patients who underwent treatment for LC at our institution from November 1994 to August 2009 were identified and their medical records were reviewed and analyzed...
July 2011: Practical Radiation Oncology
Adam Whittington, Brandi Kenner-Bell
A 7-week-old boy presented to the pediatric dermatology clinic for evaluation of diffuse blue lesions on the skin. The mother first noticed a bluish lesion on the left thigh at 6 to 7 weeks of age. The child quickly developed several similar lesions and deeper nodules on the head, arms, and trunk. He had a history of ankyloglossia and subsequent uncomplicated repair, as well as a sister with neonatal anemia. He was otherwise well and thriving. Review of systems was unremarkable. His birth involved an uncomplicated delivery, with negative maternal serology...
January 1, 2014: Pediatric Annals
Dong Keun Seok, Sae Yoon Kee, Soon Young Ko, Jung Hwa Lee, Hye Young Kim, In Sun Kim, Hee Yeon Seo
Acute myeloid leukemia presenting as leukemia cutis (LC) with hepatocellular carcinoma is extremely rare. The current study presents a case of a 53-year-old male with generalized cutaneous nodules on the face and anterior chest wall. Laboratory tests, including bone marrow biopsy revealed acute myelomonocytic leukemia (AML-M4) with skin and tonsilar involvement. Liver magnetic resonance imaging (MRI) revealed a 6-cm mass in hepatic segments 4 and 8, and a liver biopsy demonstrated that hepatocellular carcinoma cells and immature blast cells coexisted...
November 2013: Oncology Letters
Dimitrios Farmakiotis, Ana Mercedes Ciurea, Lizbeth Cahuayme-Zuniga, Dimitrios P Kontoyiannis
OBJECTIVE: To determine the diagnostic yield of skin biopsy in patients with leukemia, new skin lesions, and suspected infection. METHODS: We reviewed the medical records of all patients with leukemia who underwent skin biopsy for new lesions and clinical suspicion of infection over 4 years. Biopsy was considered to have changed the diagnosis, if the results differed from the prior leading clinical impression. RESULTS: Seventy-six (39%) of 195 patients had infections identified via skin biopsy...
October 2013: Journal of Infection
May P Chan, Lyn M Duncan, Rosalynn M Nazarian
BACKGROUND: The association of neutrophilic dermatoses with myeloid disorders is well known, but neutrophilic panniculitis in the same setting has only been reported infrequently. OBJECTIVE: We aimed to better characterize these lesions clinically and histologically, and to provide a comprehensive differential diagnosis and appropriate diagnostic approach. METHODS: The pathology archives were searched for cases of neutrophilic panniculitis in patients with myeloid disorders...
June 2013: Journal of the American Academy of Dermatology
Sasima Eimpunth, Penvadee Pattanaprichakul, Panitta Sitthinamsuwa, Leena Chularojanamontri, Piyaroj Sethabutra, Punkae Mahaisavariya
Background  "Tender cutaneous nodules of the legs" is a common manifestation in dermatology. Histopathological investigation is usually required for this condition, because clinical data are frequently insufficient to make a definite diagnosis. Objective  To identify and analyze the causes of patients presenting with tender leg nodules and to reveal clinical clues that could help to differentiate causes. Materials and methods  The medical records and histopathological slides of patients presenting with tender cutaneous nodules of the legs between January 2005 and December 2007 were retrospectively reviewed...
May 2013: International Journal of Dermatology
Laju M Patel, Amin Maghari, Robert A Schwartz, Rajendra Kapila, Aaron J Morgan, W Clark Lambert
Cutaneous involvement by myeloid leukemic cells is an unusual phenomenon. Clinical manifestations vary from erythematous papules to plum-colored plaques and nodules that may become purpuric and ulcerate. The definitive diagnosis of myeloid leukemia cutis requires the analysis of biopsy specimens using immunohistochemical staining to determine the expression of selective cell surface markers. We will review myeloid leukemia when first evident in the skin, particularly in the setting of myelodysplastic syndrome...
April 2012: International Journal of Dermatology
Pasquale Fino, Paolo Fioramonti, Maria Giuseppina Onesti, Daniele Passaretti, Nicolò Scuderi
The reported case of Hairy cell leukemia (HCL) refers to a 47-year-old man with pancytopenia, splenomegaly, a month and a half history of dyspnea on mild effort and in common daily activities and a purplish-brown cutaneous node on the back of the left hand at the time of hospital admission. Bone marrow aspiration showed an infiltration by a lymphoproliferative malignancy and the following cytochemical studies on bone marrow sample led to diagnosis of HCL. The biopsy of the skin lesion revealed a infiltrate of medium and large-size cells in the dermis with the the same cytologic features of leukemic blasts appearing in the bone marrow, upon which the diagnosis of Leukemia cutis was established...
March 2012: In Vivo
Autumn M Starnes, Douglas R Kast, Kurt Lu, Kord Honda
Leukemia Cutis (LC) has many clinical morphologies that present a diagnostic challenge. This case report of a 58-year-old man experiencing a flare of psoriasis elucidates the need for clinical suspicion when a history of leukemia is present. A skin biopsy revealed histopathologic findings of psoriasis and an infiltrate of mononuclear cells consistent with LC. Upon review of the literature, 2 additional cases were reported of concurrent psoriasis and LC.
May 2012: American Journal of Dermatopathology
Rahel A Mathew, John M Bennett, Jane Jijun Liu, Rami S Komrokji, Jeffrey E Lancet, Mojdeh Naghashpour, Jane L Messina, Alan F List, Lynn C Moscinski, Ling Zhang
Our retrospective analysis explored the role of leukemia cutis (LC) in disease progression of chronic myelomonocytic leukemia (CMML). Of 108 patients with CMML, 11 patients (10.2%) had LC including its equivalent (2 patients). Four of these patients developed acute myeloid leukemia (AML) within 0-4 months. The remaining 7 patients demonstrated increased monocytes (<20% blasts), with 3 demonstrating extramedullary involvement. Overall survival from LC to disease progression was 7.8 months. Overall survival from diagnosis to the last follow-up in patients with LC was 28...
January 2012: Leukemia Research
Jamison D Feramisco, Jennifer L Hsiao, Lindy P Fox, Beth S Ruben
Leukemia cutis represents the cutaneous infiltration of neoplastic leukocytes or their precursors that results in clinically identifiable skin lesions. For patients with myelodysplastic syndrome, developing such a lesion may indicate impending leukemic transition. These patients are also often immunocompromised, putting them at risk for infection by opportunistic fungal pathogens such as Fusarium. We describe an 85-year-old man with myelodysplastic syndrome who presented with a reddish-purple nodule with a surrounding erythematous plaque on his shin...
November 2011: Journal of Cutaneous Pathology
Shareef Jandali, Richard E Kirschner
We present a case of congenital leukemia cutis that was the presenting sign of systemic acute myeloid leukemia. The initial diagnosis was benign hemangiomatosis because ultrasound of the liver was negative for visceral involvement. However, biopsy showed monocytic cells and led to a further workup which involved a bone marrow biopsy, giving the final diagnosis of acute myeloid leukemia with leukemia cutis. Even with a thorough knowledge of the differential diagnosis of such presenting lesions, a diagnostic biopsy is often needed for a final histologic diagnosis, to proceed with the proper course of treatment...
March 2011: Annals of Plastic Surgery
Maria Pilar Bas Suárez, Jezabel López Brito, Candelaria Santana Reyes, Manuel Gresa Muñoz, Rosario Diaz Pulido, Jose Carlos Lodos Rojas
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis...
April 2011: European Journal of Pediatrics
Shino Bay Aguilera, Matthew Zarraga, Les Rosen
Leukemia cutis is an infiltration of malignant neoplastic leukocytes or their precursors into the epidermis, dermis, or subcutis. These neoplastic cells are derived from abnormal leukocytes in the bone marrow where maturation aberrations occur. Acute myelogenous leukemia (AML) is the second most common cause of leukemia cutis and the most common leukemia among adults. In the elderly population, AML presents a challenge to the medical community because of the number of preexisting comorbid conditions and the safety profile of useful chemotherapeutic agents...
January 2010: Cutis; Cutaneous Medicine for the Practitioner
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"