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https://www.readbyqxmd.com/read/28101017/efficacy-of-a-film-forming-medical-device-containing-piroxicam-and-sun-filters-in-the-treatment-of-multiple-actinic-keratosis-lesions-in-a-subject-with-a-history-of-kaposi-sarcoma
#1
Elisabetta Scotti, Salvatore Deledda, Massimo Milani
Actinic keratosis (AK) is considered a premalignant form of skin cancer due to chronic sun exposure. In addition, human papilloma virus (HPV) has been advocated a role in the pathogenesis of this clinical condition. HPV proteins (mainly E6 and E7) seem to act synergistically with ultraviolet (UV) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after UV damage. Data regarding the involvement of other viruses, i.e. human herpes viruses (HHV), in the pathogenesis of AK are so far controversial...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28099592/epidemiological-analysis-of-occupational-dermatitis-notified-in-brazil-in-the-period-2007-to-2012
#2
Gabriela Yumi Plombom, Mariana Santos de Oliveira, Fernanda Lika Tabushi, Amanda Joekel Kassem, Kátia Sheylla Malta Purim, Renato Mitsunori Nisihara
BACKGROUND: Occupational dermatitis affects the quality of life and productivity of workers. Studies on the subject are scarce in Brazil. It is estimated that the disease is underreported and that many affected patients do not seek health care. OBJECTIVES: To conduct an epidemiological analysis of occupational dermatitis notified via SINAN in Brazil from January 2007 to December 2012; evaluate the profile of patients assisted; and check the main etiological agents involved...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28098722/prevalence-of-preservatives-across-all-product-types-in-the-contact-allergen-management-program
#3
Kevin M Beene, Andrew Scheman, Dave Severson, Margo J Reeder
BACKGROUND: Preservatives are known causes of allergic contact dermatitis. OBJECTIVE: The aim of this study was to determine the prevalence of preservatives in each product category in the Contact Allergen Management Program and compare prevalence with reported rates of allergic contact dermatitis. METHODS: Contact Allergen Management Program product information was queried based on the 53 approved preservatives for cosmetic products by the European Union and Association of Southeast Asian Nations plus 5 additional preservatives used in US products...
January 2017: Dermatitis
https://www.readbyqxmd.com/read/28098721/the-endocannabinoid-system-and-its-role-in-eczematous-dermatoses
#4
Alexandra R Trusler, Ashley K Clark, Raja K Sivamani, Vivian Y Shi
The skin serves as the foremost barrier between the internal body and the external world, providing crucial protection against pathogens and chemical, mechanical, and ultraviolet damages. The skin is a central player in the intricate network of immune, neurologic, and endocrine systems. The endocannabinoid system (ECS) includes an extensive network of bioactive lipid mediators and their receptors, functions to modulate appetite, pain, mood, and memory, and has recently been implicated in skin homeostasis. Disruption of ECS homeostasis is implicated in the pathogenesis of several prevalent skin conditions...
January 2017: Dermatitis
https://www.readbyqxmd.com/read/28096423/trogocytosis-of-peptide-mhc-class-ii-complexes-from-dendritic-cells-confers-antigen-presenting-ability-on-basophils
#5
Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama
Th2 immunity plays important roles in both protective and allergic responses. Nevertheless, the nature of antigen-presenting cells responsible for Th2 cell differentiation remains ill-defined compared with the nature of the cells responsible for Th1 and Th17 cell differentiation. Basophils have attracted attention as a producer of Th2-inducing cytokine IL-4, whereas their MHC class II (MHC-II) expression and function as antigen-presenting cells are matters of considerable controversy. Here we revisited the MHC-II expression on basophils and explored its functional relevance in Th2 cell differentiation...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095636/no-contact-allergy-to-acrylic-acid-and-methacrylic-acid-in-routinely-tested-dermatitis-patients
#6
Magnus Bruze, Martin Mowitz, Erik Zimerson, Ola Bergendorff, Jakob Dahlin, Malin Engfeldt, Marléne Isaksson, Ann Pontén, Cecilia Svedman
No abstract text is available yet for this article.
February 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28095635/allergic-contact-dermatitis-caused-by-panthenol-a-rare-but-relevant-sensitizer
#7
Ilse Clerens, An Goossens
No abstract text is available yet for this article.
February 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28095633/allergic-contact-dermatitis-caused-by-textile-dyes-mimicking-atopic-dermatitis
#8
Abdiweli A Mohamoud, Flemming Andersen
No abstract text is available yet for this article.
February 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28095631/occupational-allergic-contact-dermatitis-caused-by-thebaine-and-oripavine
#9
Sam Dekeyser, Mieke van Tomme, Barbara Boone, Nanja van Geel, Hilde Lapeere
No abstract text is available yet for this article.
February 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28095574/managing-occupational-irritant-contact-dermatitis-using-a-two-step-skincare-regimen-designed-to-prevent-skin-damage-and-support-skin-recovery
#10
Erika C von Grote, Kiruthi Palaniswarmy, Matthew H Meckfessel
Occupational irritant contact dermatitis (ICD) affecting the hands is a common and difficult-to-manage condition. Occupations that necessitate contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing elevate the risk of ICD. Management strategies that do not adequately prevent accumulated damage and repair skin, can develop into chronic dermatoses which negatively impact work productivity and quality of life. A 2-step skin-care regimen (Excipial Daily Protection Hand Cream (EP) and Excipial Rapid Repair Hand Cream (ER), Galderma Laboratories, L...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095569/efficacy-of-a-hand-regimen-in-skin-barrier-protection-in-individuals-with-occupational-irritant-contact-dermatitis
#11
Laura Jordan
BACKGROUND: Occupational irritant contact dermatitis (OICD) is a dif cult and hard to manage condition. It occurs more frequently in certain occupations where contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing heightens the risk. Treatment for OICD includes patient education in addition to physical, topical, and systemic therapies. OBJECTIVE: To review the pathogenesis and treatment options for OICD and evaluate the ef cacy of a selective skin-care regimen involv- ing a hand protectant cream alone as well as combined with a repair cream and speci c cleanser...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28092944/reaction-chemistry-to-characterize-the-molecular-initiating-event-in-skin-sensitization-a-journey-to-be-continued
#12
Andreas Natsch, Roger Emter
The publication by the OECD of the adverse outcome pathway (AOP) for skin sensitization has accelerated the development and validation of mechanistic tests and testing strategies to assess the potential of new molecules to trigger skin allergies. The molecular initiating event (MIE) in the AOP is reaction with skin peptides/proteins. It is followed by a number of cellular events. Currently, only one in chemico test to characterize the MIE was proposed to and underwent adoption by the OECD, while two cell-based assays have completed the process...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28089777/bioresorbable-vascular-scaffold-to-treat-malignant-in-stent-restenosis-in-a-patient-with-nickel-allergy
#13
Alfonso Jurado-Román, María T López-Lluva, Ignacio Sánchez-Pérez, Jesús Piqueras-Flores, Ramón Maseda, Fernando Lozano-Ruíz-Poveda
Nickel is the most frequent allergen in patients with allergic contact dermatitis and nickel allergy has been associated with recurrent in-stent restenosis. However, it is often misdiagnosed because of a low suspicion threshold. It should be discarded in patients with recurrent in-stent restenosis, especially if their medical history reveals prior contact dermatitis. It is also noteworthy and rarely specified that even newer generation stents that use novel metal alloys also contain low amounts of nickel. To avoid the implantation of new stents containing this metal, when percutaneous coronary intervention is indicated, drug eluting balloons or bioresorbable vascular scaffolds associated with small doses of steroids could provide good alternatives of treatment...
January 2, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28079921/four-cases-of-exogenous-acral-pigmentation-related-to-a-darkeling-beetle-coleoptera-tenebrionidae-blaps
#14
S Mokni, L Boussofara, W Saidi, A Aounallah, C Belajouza, N Ghariani, R Nouira, M Denguezli
Beetle (coleoptera) is the largest insect order colonizing all continents 1-2. Most of the beetles synthesize hemolymph containing several chemicals used as signals or defensive secretions against predators 2. Coleoptera body fluids can accidentally come into contact with humans' skin and induce dermatitis. Skin contact with the beetles commonly causes blistering skin eruption 3. This article is protected by copyright. All rights reserved.
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28063525/the-impact-of-skin-diseases-on-quality-of-life-a-multicenter-study
#15
G Sanclemente, C Burgos, J Nova, F Hernández, C González, M I Reyes, N Córdoba, Á Arévalo, E Meléndez, J Colmenares, S Ariza, G Hernández
INTRODUCTION: To date, no formal study has been published regarding how Colombian patients with skin disorders could be affected according to their perception of disease. OBJECTIVE: To determine the impact in quality of life of skin diseases in a Colombian population. METHODS: This multicenter study included patients with skin disease from almost the whole country. Individuals >18 years old; of any gender; with any skin disease and who signed informed consent, were included...
January 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28063094/stasis-dermatitis-pathophysiology-evaluation-and-management
#16
REVIEW
Swaminathan Sundaresan, Michael R Migden, Sirunya Silapunt
Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Stasis dermatitis presents initially as poorly demarcated erythematous plaques of the lower legs bilaterally, classically involving the medial malleolus...
January 6, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28063036/visualization-of-the-t-cell-response-in-contact-hypersensitivity
#17
Gyohei Egawa, Kenji Kabashima
Contact hypersensitivity (CHS) is the most basic murine model for type IV hypersensitivity. This dermatitis model is mediated by hapten-sensitized, skin-infiltrating T cells. Recent intravital imaging studies have demonstrated the dynamic migratory property of skin-infiltrating T cells and the orchestrated interaction of T cells with dermal dendritic cells. Multiphoton microscopy enables the direct, three-dimensional, and minimally invasive imaging of in vivo skin samples with high spatiotemporal resolution...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28057923/a-derivatization-enhanced-detection-strategy-in-mass-spectrometry-analysis-of-4-hydroxybenzoates-and-their-metabolites-after-keratinocytes-are-exposed-to-uv-radiation
#18
Yi-Hsuan Lee, Ying-Chi Lin, Chia-Hsien Feng, Wei-Lung Tseng, Chi-Yu Lu
4-Hydroxybenzoate is a phenolic derivative of alkyl benzoates and is a widely used preservative in cosmetic and pharmaceutical products. The presence of 4-hydroxybenzoates in the human body may result from the use of pharmaceutical and personal care products. These compounds are also known to exhibit estrogenic and genotoxic activities. The potential adverse effects of these compounds include endocrine disruption, oxidative and DNA damage, contact dermatitis, and allergic reactions. This study used two mass spectrometry methods that are applicable when using a derivatization-enhanced detection strategy (DEDS) to screen 4-hydroxybenzoates and their metabolites...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052797/involvement-of-micrornas-in-skin-disorders-a-literature-review
#19
Carmen Mannucci, Marco Casciaro, Paola L Minciullo, Gioacchino Calapai, Michele Navarra, Sebastiano Gangemi
BACKGROUND: miRNAs are a class of noncoding RNA molecules that modulate gene expression after transcription. It is known that miRNAs are involved in various cellular processes of both normal and diseased skin. Recently, differential expressions of miRNAs have been reported and associated with several immunologic and inflammatory disorders, which indicate a common role in fundamental biologic processes. OBJECTIVE: To collect and review data from the literature on involvement of miRNA in inflammatory skin disorders...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28050486/patch-test-as-a-diagnostic-tool-in-hand-eczema
#20
Natarajan Vigneshkarthik, Satyaki Ganguly, Sheela Kuruvila
INTRODUCTION: Allergic contact dermatitis is an important cause of hand eczema. Patch testing is the only investigation available to prove the diagnosis of allergic contact dermatitis. Exposures to allergens differ according to geographical, occupational, economic and social factors. Accordingly, patterns of allergic contact dermatitis differ in different parts of the world and different regions of the same country. AIM: To study the causes of allergic contact dermatitis in adult patients with hand eczema with the help of patch testing...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
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