keyword
https://read.qxmd.com/read/38316204/impact-of-culture-media-on-primary-human-corneal-endothelial-cells-derived-from-old-donors
#21
JOURNAL ARTICLE
Alessia Merra, Eleonora Maurizi, Graziella Pellegrini
Corneal endothelial dysfunction is a major indication for corneal transplantation. However, a global shortage of donor corneal tissues and risks associated with corneal surgeries have prompted exploration of alternative options, including tissue-engineered grafts or cell injection therapy. Nonetheless, these approaches require a controlled culture of primary human corneal endothelial cells (HCEnCs). Although HCEnCs established from young donors are generally more proliferative and maintain a better phenotype, corneas from old donors are more frequently accessible from eye banks due to a lower corneal endothelial cell count than the necessary threshold required for transplantation...
February 3, 2024: Experimental Eye Research
https://read.qxmd.com/read/38315148/incorporation-of-decidual-stromal-cells-derived-exosomes-in-sodium-alginate-hydrogel-as-an-innovative-therapeutic-strategy-for-advancing-endometrial-regeneration-and-reinstating-fertility
#22
JOURNAL ARTICLE
Yuxiang Liang, Qizhi Shuai, Xiao Zhang, Shanshan Jin, Yuqian Guo, Zhaowei Yu, Xinrui Xu, Ruifang Ao, Zhiwei Peng, Huimin Lv, Sheng He, Chunfang Wang, Guohua Song, Zhizhen Liu, Hong Zhao, Qilong Feng, Ruochen Du, Bin Zheng, Zhaoyang Chen, Jun Xie
Intrauterine adhesion (IUA) stands as a prevalent medical condition characterized by endometrial fibrosis and scar tissue formation within the uterine cavity, resulting in infertility and, in severe cases, recurrent miscarriages. Cell therapy, especially with stem cells, offers an alternative to surgery, but concerns about uncontrolled differentiation and tumorigenicity limit its use. Exosomes, more stable and immunogenicity-reduced than parent cells, have emerged as a promising avenue for IUA treatment. In this study, a novel approach has been proposed wherein exosomes originating from decidual stromal cells are encapsulated within sodium alginate hydrogel (SAH) scaffolds to repair endometrial damage and restore fertility in a mouse IUA model...
February 5, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38286373/development-of-an-injectable-chitosan-based-hydrogel-containing-nano-hydroxy-apatite-and-alendronate-for-msc-based-therapy
#23
JOURNAL ARTICLE
Nesa Barpour, Marjan Ghorbani, Behzad Baradaran, Zahra Jodari-Mohammadpour, Kazem Nejati-Koshki, Meghdad Abdollahpour-Alitappeh, Rozhin Dabbaghi, Tohid Gharibi
BACKGROUND: The combination of cells and biomaterials has become a powerful approach to regenerative medicine in recent years. Understanding the in-vitro interactions between cells and biomaterials is crucial for the success of regenerative medicine. AIM: In this study, we developed an AD-pectin/chitosan/nano-crystalline cellulose scaffold with nano-hydroxy-apatite (n-HAP) and alendronate (ALN). The second step was to evaluate its effect on the immunomodulatory properties and biological behaviors of seeded adipose-derived mesenchymal stem cells (ADSCs) for bone tissue repair...
January 27, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38286209/mesenchymal-stem-cell-based-therapy-for-osteoporotic-bones-effects-of-the-interaction-between-cells-from-healthy-and-osteoporotic-rats-on-osteoblast-differentiation-and-bone-repair
#24
JOURNAL ARTICLE
Alann Thaffarell Portilho Souza, Gileade Pereira Freitas, Helena Bacha Lopes, Denise Weffort, Leticia Faustino Adolpho, Maria Paula Oliveira Gomes, Fabiola Singaretti Oliveira, Adriana Luisa Gonçalves Almeida, Marcio Mateus Beloti, Adalberto Luiz Rosa
AIMS: Cell therapy utilizing mesenchymal stem cells (MSCs) from healthy donors (HE-MSCs) is a promising strategy for treating osteoporotic bone defects. This study investigated the effects of interaction between HE-MSCs and MSCs from osteoporotic donors (ORX-MSCs) on osteoblast differentiation of MSCs and HE-MSCs on bone formation in calvarial defects of osteoporotic rats. MATERIALS AND METHODS: Osteoporosis was induced by orchiectomy (ORX) and its effects on the bone were evaluated by femur microtomography (μCT) and osteoblast differentiation of bone marrow MSCs...
January 27, 2024: Life Sciences
https://read.qxmd.com/read/38271467/multiphysics-simulation-of-magnetoelectric-micro-core-shells-for-wireless-cellular-stimulation-therapy-via-magnetic-temporal-interference
#25
JOURNAL ARTICLE
Ram Prasadh Narayanan, Ali Khaleghi, Mladen Veletić, Ilangko Balasingham
This paper presents an innovative approach to wireless cellular stimulation therapy through the design of a magnetoelectric (ME) microdevice. Traditional electrophysiological stimulation techniques for neural and deep brain stimulation face limitations due to their reliance on electronics, electrode arrays, or the complexity of magnetic induction. In contrast, the proposed ME microdevice offers a self-contained, controllable, battery-free, and electronics-free alternative, holding promise for targeted precise stimulation of biological cells and tissues...
2024: PloS One
https://read.qxmd.com/read/38267422/age-related-secretion-of-grancalcin-by-macrophages-induces-skeletal-stem-progenitor-cell-senescence-during-fracture-healing
#26
JOURNAL ARTICLE
Nan-Yu Zou, Ran Liu, Mei Huang, Yu-Rui Jiao, Jie Wei, Yangzi Jiang, Wen-Zhen He, Min Huang, Yi-Li Xu, Ling Liu, Yu-Chen Sun, Mi Yang, Qi Guo, Yan Huang, Tian Su, Ye Xiao, Wei-Shan Wang, Chao Zeng, Guang-Hua Lei, Xiang-Hang Luo, Chang-Jun Li
Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but the causes of SSPC senescence remain unclear. In this study, we revealed that macrophages in calluses secrete prosenescent factors, including grancalcin (GCA), during aging, which triggers SSPC senescence and impairs fracture healing. Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair. Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence...
January 25, 2024: Bone Research
https://read.qxmd.com/read/38255258/short-term-clinical-assessment-of-treating-female-androgenetic-alopecia-with-autologous-stem-cells-derived-from-human-hair-follicles
#27
JOURNAL ARTICLE
Katarzyna Krefft-Trzciniecka, Zuzanna Piętowska, Alicja Pakiet, Danuta Nowicka, Jacek C Szepietowski
BACKGROUND: Androgenetic alopecia (AGA) is the most common form of alopecia, but treatment options are limited. This study evaluated clinical improvement in hair condition in women with AGA six months after a single injection of autologous cell micrografts (ACMs) containing hair follicle stem cells and dermal papilla cells. METHODS: Twenty-three women with clinically and dermoscopy-confirmed AGA were included. Five 2.5 mm punch biopsies were taken from the skin of each patient with the Regenera device...
January 11, 2024: Biomedicines
https://read.qxmd.com/read/38248433/radiological-insights-into-sacroiliitis-a-narrative-review
#28
REVIEW
Asma'a Al-Mnayyis, Shrouq Obeidat, Ammar Badr, Basil Jouryyeh, Saif Azzam, Hayat Al Bibi, Yara Al-Gwairy, Sarah Al Sharie, Giustino Varrassi
Sacroiliitis is the inflammation of the sacroiliac joint, the largest axial joint in the human body, contributing to 25% of lower back pain cases. It can be detected using various imaging techniques like radiography, MRI, and CT scans. Treatments range from conservative methods to invasive procedures. Recent advancements in artificial intelligence offer precise detection of this condition through imaging. Treatment options range from physical therapy and medications to invasive methods like joint injections and surgery...
January 3, 2024: Clinics and Practice
https://read.qxmd.com/read/38247203/a-pro-regenerative-supramolecular-prodrug-protects-against-and-repairs-colon-damage-in-experimental-colitis
#29
JOURNAL ARTICLE
Kelsey G DeFrates, Elaine Tong, Jing Cheng, Ellen Heber-Katz, Phillip B Messersmith
Structural repair of the intestinal epithelium is strongly correlated with disease remission in inflammatory bowel disease (IBD); however, ulcer healing is not addressed by existing therapies. To address this need, this study reports the use of a small molecule prolyl hydroxylase (PHD) inhibitor (DPCA) to upregulate hypoxia-inducible factor one-alpha (HIF-1α) and induce mammalian regeneration. Sustained delivery of DPCA is achieved through subcutaneous injections of a supramolecular hydrogel, formed through the self-assembly of PEG-DPCA conjugates...
January 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38246086/stem-cell-based-therapy-in-cardiac-repair-after-myocardial-infarction-promise-challenges-and-future-directions
#30
REVIEW
Wenjun Yan, Yunlong Xia, Huishou Zhao, Xiaoming Xu, Xinliang Ma, Ling Tao
Stem cells represent an attractive resource for cardiac regeneration. However, the survival and function of transplanted stem cells is poor and remains a major challenge for the development of effective therapies. As two main cell types currently under investigation in heart repair, mesenchymal stromal cells (MSCs) indirectly support endogenous regenerative capacities after transplantation, while induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) functionally integrate into the damaged myocardium and directly contribute to the restoration of its pump function...
January 20, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38243682/induced-pluripotent-stem-cell-derived-extracellular-vesicles-enriched-with-mir-126-induce-proangiogenic-properties-and-promote-repair-of-ischemic-tissue
#31
JOURNAL ARTICLE
Katarzyna Kmiotek-Wasylewska, Anna Łabędź-Masłowska, Sylwia Bobis-Wozowicz, Elżbieta Karnas, Sylwia Noga, Małgorzata Sekuła-Stryjewska, Olga Woźnicka, Zbigniew Madeja, Buddhadeb Dawn, Ewa K Zuba-Surma
Emerging evidence suggests that stem cell-derived extracellular vesicles (EVs) may induce pro-regenerative effects in ischemic tissues by delivering bioactive molecules, including microRNAs. Recent studies have also shown pro-regenerative benefits of EVs derived from induced pluripotent stem (iPS) cells. However, the underlying mechanisms of EV benefits and the role of their transferred regulatory molecules remain incompletely understood. Accordingly, we investigated the effects of human iPS-derived EVs (iPS-EVs) enriched in proangiogenic miR-126 (iPS-miR-126-EVs) on functional properties of human endothelial cells (ECs) in vitro...
January 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38234679/long-term-improvement-of-knee-osteoarthritis-after-injection-of-single-high-very-high-volume-of-very-pure-prp-a-retrospective-analysis-of-patients-optimally-managed-in-dedicated-centers
#32
JOURNAL ARTICLE
Didier Prost, Thomas Bardot, Alexandre Baud, Anthony Calvo, Stephane Aumont, Herve Collado, Julien Borne, Olivier Rajon, Antoine Ponsot, Alexandra Malaterre, Yannis Dahak, Guy Magalon, Florence Sabatier, Jeremy Magalon
INTRODUCTION: PRP is gaining increasing interest for pain relief and improvement of joint function in patients with knee osteoarthritis (KOA) but practices and results remain heterogeneous limiting its adoption as standard of care. Current international recommendations are to collect real-life evidence of efficacy with a systematic monitoring of PRP quality and patients' outcomes. We aimed to analyze the response of patients presenting KOA and treated with standardized PRP injection in routine care...
March 2024: Regenerative Therapy
https://read.qxmd.com/read/38229707/a-promising-application-of-injectable-hydrogels-in-nerve-repair-and-regeneration-for-ischemic-stroke
#33
REVIEW
Yuan Gao, Ting-Lin Zhang, Hong-Jian Zhang, Jie Gao, Peng-Fei Yang
Ischemic stroke, a condition that often leads to severe nerve damage, induces complex pathological and physiological changes in nerve tissue. The mature central nervous system (CNS) lacks intrinsic regenerative capacity, resulting in a poor prognosis and long-term neurological impairments. There is no available therapy that can fully restore CNS functionality. However, the utilization of injectable hydrogels has emerged as a promising strategy for nerve repair and regeneration. Injectable hydrogels possess exceptional properties, such as biocompatibility, tunable mechanical properties, and the ability to provide a supportive environment for cell growth and tissue regeneration...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38218753/a-new-lymphedema-treatment-using-pyro-drive-jet-injection
#34
JOURNAL ARTICLE
Megumi Nishiyama, Yuko Sakaguchi, Sayuri Morito, Kei Nagase, Takehisa Sakumoto, Kunihiko Yamashita, Mariko Hashiguchi, Makoto Fukuda, Shuji Toda, Shigehisa Aoki
Lymphedema, resulting from impaired lymphatic drainage, causes inflammation, fibrosis and tissue damage leading to symptoms such as limb swelling and restricted mobility. Despite various treatments under exploration, no standard effective therapy exists. Here a novel technique using the pyro-drive jet injection (PJI) was used to create artificial clefts between collagen fibers, which facilitated the removal of excess interstitial fluid. The PJI was used to deliver a mixture of lactated Ringer's solution and air into the tail of animals with secondary skin edema...
January 14, 2024: Human Cell
https://read.qxmd.com/read/38204673/prospective-randomized-controlled-trial-of-the-safety-and-feasibility-of-a-novel-mesenchymal-precursor-cell-therapy-in-hypoplastic-left-heart-syndrome
#35
JOURNAL ARTICLE
Rachel E Wittenberg, Kimberlee Gauvreau, Jonah Leighton, Melinda Moleon-Shea, Kenneth M Borow, Gerald R Marx, Sitaram M Emani
OBJECTIVE: To assess the safety and feasibility of low-dose, novel, allogenic mesenchymal precursor cell (MPC) therapy as an adjunct to left ventricular (LV) recruitment for patients with hypoplastic left heart syndrome (HLHS) and borderline left ventricles. MPC injections into the hypoplastic left ventricle may stimulate neovascularization and beneficial LV remodeling and may improve the likelihood of achieving biventricular (BiV) or 1.5 ventricle (1.5V) circulation. METHODS: Children <5 years with prior single ventricle palliation undergoing LV recruitment surgery at a single center were randomized to MPC injections into the LV endocardium/papillary muscles (MPCs) or standard-of-care (controls) and followed for 24 months...
December 2023: JTCVS open
https://read.qxmd.com/read/38193194/the-transplantation-of-3-dimensional-spheroids-of-adipose-derived-stem-cells-promotes-achilles-tendon-healing-in-rabbits-by-enhancing-the-proliferation-of-tenocytes-and-suppressing-m1-macrophages
#36
JOURNAL ARTICLE
Shih-Heng Chen, Yun-Wei Lee, Huang-Kai Kao, Pei-Ching Yang, Shih-Hsien Chen, Shao-Wen Liu, Pei-Ching Yang, Yu-Jie Lin, Chieh-Cheng Huang
BACKGROUND: Tendons have limited regenerative potential, so healing of ruptured tendon tissue requires a prolonged period, and the prognosis is suboptimal. Although stem cell transplantation-based approaches show promise for accelerating tendon repair, the resultant therapeutic efficacy remains unsatisfactory. HYPOTHESIS: The transplantation of stem cells preassembled as 3-dimensional spheroids achieves a superior therapeutic outcome compared with the transplantation of single-cell suspensions...
January 9, 2024: American Journal of Sports Medicine
https://read.qxmd.com/read/38193114/using-biomaterials-to-improve-mesenchymal-stem-cell-therapies-for-chronic-nonhealing-wounds
#37
REVIEW
Romina Keshavarz, Sara Olsen, Bethany Almeida
Historically, treatment of chronic, nonhealing wounds has focused on managing symptoms using biomaterial-based wound dressings, which do not adequately address the underlying clinical issue. Mesenchymal stem cells (MSCs) are a promising cell-based therapy for the treatment of chronic, nonhealing wounds, yet inherent cellular heterogeneity and susceptibility to death during injection limit their clinical use. Recently, researchers have begun to explore the synergistic effects of combined MSC-biomaterial therapies, where the biomaterial serves as a scaffold to protect the MSCs and provides physiologically relevant physicochemical cues that can direct MSC immunomodulatory behavior...
January 2024: Bioengineering & Translational Medicine
https://read.qxmd.com/read/38179213/mid-term-outcomes-of-microfragmented-adipose-tissue-plus-arthroscopic-surgery-for-knee-osteoarthritis-a-randomized-active-control-multicenter-clinical-trial
#38
JOURNAL ARTICLE
Cong-Zi Wu, Zhen-Yu Shi, Zhen Wu, Wen-Jun Lin, Wei-Bo Chen, Xue-Wen Jia, Si-Cheng Xiang, Hui-Hui Xu, Qin-Wen Ge, Kai-Ao Zou, Xu Wang, Jia-Li Chen, Ping-Er Wang, Wen-Hua Yuan, Hong-Ting Jin, Pei-Jian Tong
BACKGROUND: Osteoarthritis (OA) is the most prevalent form of degenerative whole-joint disease. Before the final option of knee replacement, arthroscopic surgery was the most widely used joint-preserving surgical treatment. Emerging regenerative therapies, such as those involving platelet-rich plasma, mesenchymal stem cells, and microfragmented adipose tissue (MFAT), have been pushed to the forefront of treatment to prevent the progression of OA. Currently, MFAT has been successfully applied to treat different types of orthopedic diseases...
December 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/38169189/injectable-microcapillary-network-hydrogels-engineered-by-liquid-liquid-phase-separation-for-stem-cell-transplantation
#39
JOURNAL ARTICLE
Akihiro Nishiguchi, Shima Ito, Kazuhiro Nagasaka, Hiyori Komatsu, Koichiro Uto, Tetsushi Taguchi
Injectable hydrogels are promising carriers for cell delivery in regenerative medicine. However, injectable hydrogels composed of crosslinked polymer networks are often non-microporous and prevent biological communication with host tissues through signals, nutrients, oxygen, and cells, thereby limiting graft survival and tissue integration. Here we report injectable hydrogels with liquid-liquid phase separation-induced microcapillary networks (μCN) as stem cell-delivering scaffolds. The molecular modification of gelatin with hydrogen bonding moieties induced liquid-liquid phase separation when mixed with unmodified gelatin to form μCN structures in the hydrogels...
December 28, 2023: Biomaterials
https://read.qxmd.com/read/38160855/injectable-hydrogel-induces-regeneration-of-naturally-degenerate-human-intervertebral-discs-in-a-loaded-organ-culture-model
#40
JOURNAL ARTICLE
Hosni Cherif, Li Li, Joseph Snuggs, Xuan Li, Christopher Sammon, Jianyu Li, Lorne Beckman, Lisbet Haglund, Christine L Le Maitre
Low back pain resulting from disc degeneration is a leading cause of disability worldwide. However, to date few therapies target the cause and fail to repair the intervertebral disc (IVD). This study investigates the ability of an injectable hydrogel (NPgel), to inhibit catabolic protein expression and promote matrix expression in human nucleus pulposus (NP) cells within a tissue explant culture model isolated from degenerate discs. Furthermore, the injection capacity of NPgel into naturally degenerate whole human discs, effects on mechanical function, and resistance to extrusion during loading were investigated...
December 29, 2023: Acta Biomaterialia
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