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Acute pancreatitis dog

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https://www.readbyqxmd.com/read/29519682/left-subclavian-artery-dissection-associated-with-connective-tissue-abnormalities-resembling-marfan-like-syndrome-in-an-english-bulldog
#1
Ilaria Biasato, Renato Zanatta, Lorella Maniscalco, Rocchina Evangelista, Bryan Iotti, Selina Iussich
The unexpected demise of a 12-year-old male neutered English bulldog solicited a gross examination, which revealed a blood-filled space occurring in the proximal left subclavian artery (LSA). It originated about 1 cm from the branching point of the vessel and progressively dilated for 3 cm distal to this origin. Histopathological investigation showed that the tunica media of the LSA was more than 50% split, with the blood-filled space dissecting through the arterial wall. In the tunica media of the LSA, severe multifocal fragmentation and/or loss of the elastic fibers was observed...
March 5, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29469974/assessment-of-canine-pancreas-specific-lipase-and-outcomes-in-dogs-with-hemodialysis-dependent-acute-kidney-injury
#2
K Takada, C A Palm, S E Epstein, L D Cowgill
BACKGROUND: Renal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome. HYPOTHESIS/OBJECTIVES: To investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements...
February 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29398674/canine-case-of-swallowing-syncope-that-improved-after-pacemaker-implantation
#3
Ryuji Fukushima, Toshiki Araie, Naoaki Itou, Takae Kawaguchi, Shusaku Yamada, Aritada Yoshimura, Seijirow Goya, Kazumi Shimada, Tsuyoshi Uchide, Miori Kishimoto, Noboru Machida
A 14-year-old intact male West Highland White Terrier weighing 6.9 kg was admitted to the Tokyo University of Agriculture and Technology Animal Medical Center with the complaint of syncope after showing signs of nausea during feeding. Sinus arrest induced by deglutition was confirmed using a Holter electrocardiography test. However, the clinical symptoms significantly improved after implantation of a permanent pacemaker. Seven months after implantation, the dog died from acute pancreatitis, a cause unrelated to the syncope...
February 5, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29371812/azole-resistance-caused-by-increased-drug-efflux-in-candida-glabrata-isolated-from-the-urinary-tract-of-a-dog-with-diabetes-mellitus
#4
Minchul Kim, Hyekyung Lee, Sun-Young Hwang, Inhyung Lee, Won Hee Jung
A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole antifungal drugs. To understand the mechanism of azole resistance in this isolate, the sequences and expression levels of the genes involved in drug resistance were analyzed. The results of our analysis showed that increased drug efflux, mediated by overexpression of ATP transporter genes CDR1 and PDH1, is the main cause of azole resistance of the C...
December 2017: Mycobiology
https://www.readbyqxmd.com/read/29343664/the-anti-inflammatory-action-of-maropitant-in-a-mouse-model-of-acute-pancreatitis
#5
Atsushi Tsukamoto, Minami Ohgoda, Nozomi Haruki, Masatoshi Hori, Tomo Inomata
The neurokinin 1 receptor (NK1R) plays an important role in the pathogenesis of acute pancreatitis (AP). Maropitant is an NK1R antagonist that is widely used as an antiemetic in dogs and cats. In the present study, we investigated the anti-inflammatory action of maropitant in a mouse model of AP. AP was induced in BALB/c mice by intraperitoneal administration of cerulein, and maropitant was administered subcutaneously at a dose of 8 mg/kg. We assessed the mRNA expression levels of NK1R and substance P (SP) in the pancreatic tissue via real-time reverse transcription polymerase chain reaction...
January 16, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29190196/clinical-and-histologic-features-of-acute-onset-erythroderma-in-dogs-with-gastrointestinal-disease-18-cases-2005-2015
#6
Christine L Cain, Charles W Bradley, Elizabeth A Mauldin
OBJECTIVE To describe the clinical and histologic features of acute erythroderma in dogs with gastrointestinal disease. DESIGN Retrospective case series. ANIMALS 18 dogs with erythroderma and gastrointestinal disease. PROCEDURES Medical records and biopsy specimens were reviewed. Information collected from medical records included signalment, clinical signs, physical examination and diagnostic test results, treatment, and outcome. The Naranjo algorithm was used to estimate the probability of an adverse drug reaction for each dog...
December 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29076217/elevated-serum-creatinine-and-hyponatraemia-as-prognostic-factors-in-canine-acute-pancreatitis
#7
V Marchetti, E Gori, I Lippi, E Luchetti, M L Manca, A Pierini
OBJECTIVE: To evaluate prognostic factors for canine acute pancreatitis (AP) based on clinical and laboratory data that can be easily assessed in veterinary practice. DESIGN: Retrospective study between January 2010 and December 2013. METHODS: The diagnosis of AP was based on clinical signs and an abnormal SNAP® cPL™ test result, concurrently with an ultrasound pattern suggestive of pancreatitis. Dogs were divided into survivors and non-survivors...
November 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28659537/serum-25-hydroxyvitamin-d-concentrations-in-dogs-with-suspected-acute-pancreatitis
#8
Dong-In Kim, Hakhyun Kim, Purum Son, Ji-Houn Kang, Byeong-Teck Kang, Mhan-Pyo Yang
The present study aimed to determine whether circulating serum concentrations of 25-hydroxyvitamin D [25-(OH) D] differed between healthy dogs and dogs with acute pancreatitis (AP). Twenty-two healthy dogs and twenty client-owned dogs with AP were enrolled in the study. Serum concentrations of 25-(OH) D, blood ionized calcium (iCa), and serum C-reactive protein (CRP) were measured. Concentrations of serum 25-(OH) D and blood iCa in dogs with AP were significantly lower than those of healthy dogs, and serum concentrations of CRP in dogs with AP were significantly higher than those of healthy dogs...
August 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28513459/effects-of-granulocyte-colony-stimulating-factor-on-opsonin-receptor-expression-and-neutrophil-antibacterial-activity-in-a-mouse-model-of-severe-acute-pancreatitis
#9
Tuo Hong-Fang, Peng Yan-Hui, Bao Lei, Zhang Wan-Xing
The antimicrobial function of neutrophils, which is dependent on opsonin receptors, deteriorates in severe acute pancreatitis (SAP). Granulocyte colony-stimulating factor (G-CSF) putatively enhanced levels of the opsonin receptors CD11b and CD32/16 in healthy human subjects, and provided protection against infection in animal models of SAP. A statistically convincing study of the effect of G-CSF on CD32/16 expression in an SAP model is lacking. We used a mouse model of SAP to investigate the association between G-CSF administration and CD32/16 levels on neutrophils and bacterial translocation...
May 9, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28510290/retrospective-evaluation-of-the-impact-of-early-enteral-nutrition-on-clinical-outcomes-in-dogs-with-pancreatitis-34-cases-2010-2013
#10
Jessica P Harris, Nolie K Parnell, Emily H Griffith, Korinn E Saker
OBJECTIVE: To evaluate the effect of early enteral nutritional therapy on time to return to voluntary intake, maximum food consumption, incidence of gastrointestinal intolerance (GI), and total hospitalization time for dogs with acute pancreatitis. DESIGN AND SETTING: Retrospective analysis of dogs with pancreatitis at a veterinary teaching hospital between 2010 and 2013. ANIMALS: Thirty-four client-owned dogs diagnosed with acute or acute-on-chronic pancreatitis...
July 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28224456/zinc-toxicosis-in-a-boxer-dog-secondary-to-ingestion-of-holiday-garland
#11
Karyn Bischoff, Anne Chiapella, Jaime Weisman, Lisa M Crofton, Joseph Hillebrandt
INTRODUCTION: Increased admissions occur in small animal veterinary emergency clinics during some holidays, and some of the increased caseload is due to ingestion of toxic substances. This report documents zinc toxicosis contributing to the death of a dog after ingestion of holiday tinsel garland. CASE STUDY: A mature boxer dog presented with a 4-day history of vomiting and diarrhea. Radiodense foreign material was detected in the stomach and removed via gastrotomy...
September 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28125171/prevalence-of-increased-canine-pancreas-specific-lipase-concentrations-in-young-dogs-with-parvovirus-enteritis
#12
Irida V Kalli, Katerina K Adamama-Moraitou, Michael N Patsika, Dimitra Pardali, Jörg M Steiner, Jan S Suchodolski, George Menexes, Georgia D Brellou, Timoleon S Rallis
BACKGROUND: Pancreatic abnormalities during canine parvovirus (CPV) enteritis have not been studied prospectively. OBJECTIVES: The objective of this study was to evaluate the diagnostic significance of canine serum pancreas-specific lipase (Spec cPL) concentration in dogs with CPV enteritis for the presence of acute pancreatitis (AP). Puppies with naturally occurring CPV enteritis were recruited and prospectively allocated into 2 groups according to normal or increased serum Spec cPL concentration...
March 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28057899/retrospective-evaluation-of-circulating-thyroid-hormones-in-critically-ill-dogs-with-systemic-inflammatory-response-syndrome
#13
Massimo Giunti, Roberta Troia, Mara Battilani, Luciana Giardino, Francesco Dondi, Giulia Andreani, Federico Fracassi
Critical illness can be associated with transient alterations in circulating thyroid hormone concentrations, indicating the presence of non-thyroidal illness (NTI). NTI is well described in humans, but there are few reports on its occurrence and prognostic significance in dogs. This retrospective study assessed the occurrence of NTI in a population of dogs with systemic inflammatory response syndrome (SIRS) and investigated its association with disease severity (APPLEfast scores). A total of 41 SIRS dogs were included and were divided by SIRS origin (non-septic SIRS, n = 10; septic SIRS, n = 41) and final outcome (survivors, n = 37; non-survivors, n = 4)...
December 31, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27866884/microrna-biomarkers-of-pancreatic-injury-in-a-canine-model
#14
Rodney Rouse, Barry Rosenzweig, Katie Shea, Alan Knapton, Sharron Stewart, Lin Xu, Ashok Chockalingam, Leah Zadrozny, Karol Thompson
Pancreas-enriched microRNAs have been experimentally investigated in rodents as candidate serum biomarkers of pancreatic injury with several different acute pancreatic injury models. In the present study, temporal and magnitude responses of exocrine pancreas-enriched miR-216a, miR-216b, and miR-217 and endocrine-enriched miR-375 and miR-148a were measured by droplet digital PCR in serum in a caerulein model of pancreatic injury in the dog. All 5 microRNAs followed a similar time course that mirrored the responses of the conventional serum pancreatic injury biomarkers, amylase and lipase...
January 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27666150/assesment-of-severity-and-changes-in-c-reactive-protein-concentration-and-various-biomarkers-in-dogs-with-pancreatitis
#15
Toru Sato, Koichi Ohno, Takashi Tamamoto, Mariko Oishi, Hideyuki Kanemoto, Kenjiro Fukushima, Yuko Goto-Koshino, Masashi Takahashi, Hajime Tsujimoto
Canine pancreatitis is a relatively common disorder, and its mortality rate remains high. However, prognostic factors for pancreatitis based on evidence are limited. Moreover, the relationship between changes in C-reactive protein (CRP) concentration-an important prognostic factor for human patients with acute pancreatitis-and the prognosis of dogs with pancreatitis has not been widely studied. Therefore, we examined prognostic factors for canine pancreatitis during the first medical examination and evaluated the usefulness of serial CRP measurements during hospitalization...
January 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27623952/changes-in-biochemical-analytes-in-female-dogs-with-subclinical-ancylostoma-spp-infection
#16
Elizabeth M S Schmidt, Asta Tvarijonaviciute, Silvia Martinez-Subiela, José J Cerón, Peter D Eckersall
BACKGROUND: Ancylostoma spp. is one of the most prevalent canine intestinal nematode infections which usually causes subclinical disease in adult dogs and has zoonotic implications. Therefore, the aim of this study was to explore and evaluate the possible pathophysiological changes that Ancylostoma spp. could produce in female dogs naturally infected but without clinical signs of disease, by screening a wide variety of biochemical markers for potential changes. Samples of feces and blood of 45 dogs were collected and fecal flotation and zinc sulphate centrifugal flotation were performed...
September 13, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27418683/animal-models-of-gastrointestinal-and-liver-diseases-animal-models-of-acute-and-chronic-pancreatitis
#17
REVIEW
Xianbao Zhan, Fan Wang, Yan Bi, Baoan Ji
Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity...
September 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27408338/changes-in-gene-expression-of-tumor-necrosis-factor-alpha-and-interleukin-6-in-a-canine-model-of-caerulein-induced-pancreatitis
#18
Ruhui Song, Dohyeon Yu, Jinho Park
Acute pancreatitis is an inflammatory process that frequently involves peripancreatic tissues and remote organ systems. It has high morbidity and mortality rates in both human and veterinary patients. The severity of pancreatitis is generally determined by events that occur after acinar cell injury in the pancreas, resulting in elevated levels of various proinflammatory mediators, such as interleukin (IL) 1β and 6, as well as tumor necrosis factor alpha (TNF-α). When these mediators are excessively released into the systemic circulation, severe pancreatitis occurs with systemic complications...
July 2016: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/27398720/exenatide-treatment-alone-improves-%C3%AE-cell-function-in-a-canine-model-of-pre-diabetes
#19
Viorica Ionut, Orison O Woolcott, Hasmik J Mkrtchyan, Darko Stefanovski, Morvarid Kabir, Malini S Iyer, Huiwen Liu, Ana V B Castro, Qiang Wu, Josiane L Broussard, Cathryn M Kolka, Isaac Asare-Bediako, Richard N Bergman
BACKGROUND: Exenatide's effects on glucose metabolism have been studied extensively in diabetes but not in pre-diabetes. OBJECTIVE: We examined the chronic effects of exenatide alone on glucose metabolism in pre-diabetic canines. DESIGN AND METHODS: After 10 weeks of high-fat diet (HFD), adult dogs received one injection of streptozotocin (STZ, 18.5 mg/kg). After induction of pre-diabetes, while maintained on HFD, animals were randomized to receive either exenatide (n = 7) or placebo (n = 7) for 12 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27297425/canine-adipose-tissue-derived-mesenchymal-stem-cells-ameliorate-severe-acute-pancreatitis-by-regulating-t-cells-in-rats
#20
Hyun-Wook Kim, Woo-Jin Song, Qiang Li, Sei-Myoung Han, Kee-Ok Jeon, Sang-Chul Park, Min-Ok Ryu, Hyung-Kyu Chae, Kweon Kyeong, Hwa-Young Youn
Severe acute pancreatitis (SAP) is associated with systemic complications and high mortality rate in dogs. Mesenchymal stem cells (MSCs) have been investigated for their therapeutic potential in several inflammation models. In the present study, the effects of canine adipose tissue-derived (cAT)-MSCs in a rat model of SAP induced by retrograde injection of 3% sodium taurocholate solution into the pancreatic duct were investigated. cAT-MSCs labeled with dioctadecyl-3,3,3'-tetramethylindo-carbocyanine perchlorate (1 × 10⁷ cells/kg) were systemically administered to rats and pancreatic tissue was collected three days later for histopathological, quantitative real-time polymerase chain reaction, and immunocytochemical analyses...
December 30, 2016: Journal of Veterinary Science
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