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Acute pancreatitis dog

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https://www.readbyqxmd.com/read/27866884/microrna-biomarkers-of-pancreatic-injury-in-a-canine-model
#1
Rodney Rouse, Barry Rosenzweig, Katie Shea, Alan Knapton, Sharron Stewart, Lin Xu, Ashok Chockalingam, Leah Zadrozny, Karol Thompson
Pancreas-enriched microRNAs have been experimentally investigated in rodents as candidate serum biomarkers of pancreatic injury with several different acute pancreatic injury models. In the present study, temporal and magnitude responses of exocrine pancreas-enriched miR-216a, miR-216b, and miR-217 and endocrine-enriched miR-375 and miR-148a were measured by droplet digital PCR in serum in a caerulein model of pancreatic injury in the dog. All 5 microRNAs followed a similar time course that mirrored the responses of the conventional serum pancreatic injury biomarkers, amylase and lipase...
November 17, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27666150/assesment-of-severity-and-changes-in-c-reactive-protein-concentration-and-various-biomarkers-in-dogs-with-pancreatitis
#2
Toru Sato, Koichi Ohno, Takashi Tamamoto, Mariko Oishi, Hideyuki Kanemoto, Kenjiro Fukushima, Yuko Goto-Koshino, Masashi Takahashi, Hajime Tsujimoto
Canine pancreatitis is a relatively common disorder, and its mortality rate remains high. However, prognostic factors for pancreatitis based on evidence are limited. Moreover, the relationship between changes in C-reactive protein (CRP) concentration-an important prognostic factor for human patients with acute pancreatitis-and the prognosis of dogs with pancreatitis has not been widely studied. Therefore, we examined prognostic factors for canine pancreatitis during the first medical examination and evaluated the usefulness of serial CRP measurements during hospitalization...
September 23, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27623952/changes-in-biochemical-analytes-in-female-dogs-with-subclinical-ancylostoma-spp-infection
#3
Elizabeth M S Schmidt, Asta Tvarijonaviciute, Silvia Martinez-Subiela, José J Cerón, Peter D Eckersall
BACKGROUND: Ancylostoma spp. is one of the most prevalent canine intestinal nematode infections which usually causes subclinical disease in adult dogs and has zoonotic implications. Therefore, the aim of this study was to explore and evaluate the possible pathophysiological changes that Ancylostoma spp. could produce in female dogs naturally infected but without clinical signs of disease, by screening a wide variety of biochemical markers for potential changes. Samples of feces and blood of 45 dogs were collected and fecal flotation and zinc sulphate centrifugal flotation were performed...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27418683/animal-models-of-gastrointestinal-and-liver-diseases-animal-models-of-acute-and-chronic-pancreatitis
#4
REVIEW
Xianbao Zhan, Fan Wang, Yan Bi, Baoan Ji
Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity...
September 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27408338/changes-in-gene-expression-of-tumor-necrosis-factor-alpha-and-interleukin-6-in-a-canine-model-of-caerulein-induced-pancreatitis
#5
Ruhui Song, Dohyeon Yu, Jinho Park
Acute pancreatitis is an inflammatory process that frequently involves peripancreatic tissues and remote organ systems. It has high morbidity and mortality rates in both human and veterinary patients. The severity of pancreatitis is generally determined by events that occur after acinar cell injury in the pancreas, resulting in elevated levels of various proinflammatory mediators, such as interleukin (IL) 1β and 6, as well as tumor necrosis factor alpha (TNF-α). When these mediators are excessively released into the systemic circulation, severe pancreatitis occurs with systemic complications...
July 2016: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/27398720/exenatide-treatment-alone-improves-%C3%AE-cell-function-in-a-canine-model-of-pre-diabetes
#6
Viorica Ionut, Orison O Woolcott, Hasmik J Mkrtchyan, Darko Stefanovski, Morvarid Kabir, Malini S Iyer, Huiwen Liu, Ana V B Castro, Qiang Wu, Josiane L Broussard, Cathryn M Kolka, Isaac Asare-Bediako, Richard N Bergman
BACKGROUND: Exenatide's effects on glucose metabolism have been studied extensively in diabetes but not in pre-diabetes. OBJECTIVE: We examined the chronic effects of exenatide alone on glucose metabolism in pre-diabetic canines. DESIGN AND METHODS: After 10 weeks of high-fat diet (HFD), adult dogs received one injection of streptozotocin (STZ, 18.5 mg/kg). After induction of pre-diabetes, while maintained on HFD, animals were randomized to receive either exenatide (n = 7) or placebo (n = 7) for 12 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27297425/canine-adipose-tissue-derived-mesenchymal-stem-cells-ameliorate-severe-acute-pancreatitis-by-regulating-t-cells-in-rats
#7
Hyun-Wook Kim, Woo-Jin Song, Qiang Li, Sei-Myoung Han, Kee-Ok Jeon, Sang-Chul Park, Min-Ok Ryu, Hyung-Kyu Chae, Kweon Kyeong, Hwa-Young Youn
Severe acute pancreatitis (SAP) is associated with systemic complications and high mortality rate in dogs. Mesenchymal stem cells (MSCs) have been investigated for their therapeutic potential in several inflammation models. The present study investigated the effects of canine adipose tissue-derived (cAT)MSCs in a rat model of SAP induced by retrograde injection of 3% sodium taurocholate solution into the pancreatic duct. cATMSCs labeled with dioctadecyl-3,3,3'-tetramethylindo-carbocyanine perchlorate (1 × 10(7) cells/kg) were systemically administered to rats and pancreatic tissue was collected 3 days later for histopathological, quantitative real-time PCR, and immunocytochemical analyses...
June 13, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27169882/lung-inflammation-associated-with-clinical-acute-necrotizing-pancreatitis-in-dogs
#8
V Vrolyk, B K Wobeser, A N Al-Dissi, A Carr, B Singh
Although dogs with acute necrotizing pancreatitis (ANP) can develop respiratory complications, there are no data describing lung injury in clinical cases of ANP in dogs. Therefore, we conducted a study to characterize lung injury and determine if pulmonary intravascular macrophages (PIMs) are induced in dogs with ANP (n = 21) compared with control dogs (n = 6). Two pathologists independently graded histologic sections of pancreas from clinical cases to characterize the severity of ANP (total scores of 3-10) compared with controls showing histologically normal pancreas (total scores of 0)...
May 11, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27147282/retrospective-evaluation-of-acute-liver-failure-in-dogs-1995-2012-49-cases
#9
Carrie Lester, Johanna Cooper, Rachel M Peters, Cynthia R L Webster
OBJECTIVE: To characterize the clinical presentation and outcome of dogs with acute liver failure (ALF). DESIGN: Retrospective case series from January 1995 to December 2012. SETTING: University teaching hospital. ANIMALS: Forty-nine dogs were diagnosed with ALF defined as the acute onset of clinical signs accompanied by serum hyperbilirubinemia and coagulopathy (prothrombin time >1.5 times the upper limit of the reference interval) with or without signs of hepatic encephalopathy...
July 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27075106/beta-hydroxybutyrate-concentrations-in-dogs-with-acute-pancreatitis-and-without-diabetes-mellitus
#10
F E Hurrell, K J Drobatz, R S Hess
BACKGROUND: β-hydroxybutyrate (BOHB) concentrations have not been quantified in dogs with acute pancreatitis (AP). OBJECTIVE: The aim of this study was to investigate BOHB concentrations in dogs with AP. ANIMALS: A total of 154 client-owned dogs without DM. METHODS: Prospective clinical study. Dogs were enrolled into 1 of 3 groups: AP, sick without an AP diagnosis, or fasted. Dogs were diagnosed with AP (44) if they had vomiting or anorexia, and either ultrasonographic findings consistent with AP or increased pancreatic lipase...
May 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/26926084/thrombomodulin-expression-in-tissues-from-dogs-with-systemic-inflammatory-disease
#11
S D Kim, P Baker, J DeLay, R D Wood
Thrombomodulin (TM) is a membrane glycoprotein expressed on endothelial cells, which plays a major role in the protein C anticoagulation pathway. In people with inflammation, TM expression can be down-regulated on endothelial cells and a soluble form released into circulation, resulting in increased risk of thrombosis and disseminated intravascular coagulation. TM is present in dogs; however, there has been minimal investigation of its expression in canine tissues, and the effects of inflammation on TM expression in canine tissues have not been investigated...
July 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/26895040/reduced-pancreatic-exocrine-function-and-organellar-disarray-in-a-canine-model-of-acute-pancreatitis
#12
Yuepeng Jin, Yongyu Bai, Qiang Li, Pravin Avinash Bhugul, Xince Huang, Lewei Liu, Liangliang Pan, Haizhen Ni, Bicheng Chen, Hongwei Sun, Qiyu Zhang, Michael Hehir, Mengtao Zhou
The aim of the present study was to investigate the pancreatic exocrine function in a canine model and to analyze the changes in organelles of pancreatic acinar cells during the early stage of acute pancreatitis (AP). AP was induced by retrograde injection of 5% sodium taurocholate (0.5 ml/kg) into the main pancreatic duct of dogs. The induction of AP resulted in serum hyperamylasemia and a marked reduction of amylase activity in the pancreatic fluid (PF). The pancreatic exocrine function was markedly decreased in subjects with AP compared with the control group...
2016: PloS One
https://www.readbyqxmd.com/read/26678019/evaluation-of-canine-pancreas-specific-lipase-activity-lipase-activity-and-trypsin-like-immunoreactivity-in-an-experimental-model-of-acute-kidney-injury-in-dogs
#13
S E Hulsebosch, C A Palm, G Segev, L D Cowgill, P H Kass, S L Marks
BACKGROUND: Diagnosis of pancreatitis in dogs is complicated by extrapancreatic disorders that can alter the results of laboratory tests. Extrapancreatic disorders can also affect the diagnosis of exocrine pancreatic insufficiency (EPI). The effects of acute kidney injury (AKI) on pancreas-specific lipase activity (Spec cPL(®) Test), serum lipase activity and trypsin-like immunoreactivity (TLI) in dogs have not been evaluated. HYPOTHESIS/OBJECTIVES: Serum Spec cPL, lipase activity, and TLI concentrations will increase secondary to decreased kidney function...
January 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/26586203/clinical-utility-of-diagnostic-laboratory-tests-in-dogs-with-acute-pancreatitis-a-retrospective-investigation-in-a-primary-care-hospital
#14
M Yuki, T Hirano, N Nagata, S Kitano, K Imataka, R Tawada, R Shimada, M Ogawa
BACKGROUND: Acute pancreatitis (AP) occurs frequently in dogs, but most previous studies examining the diagnosis of AP have used data from secondary care hospitals. HYPOTHESIS/OBJECTIVES: The aim of this study was to investigate the clinical utility of diagnostic laboratory tests in dogs with AP in a primary care hospital. ANIMALS: Sixty-four dogs with clinical signs suggestive of AP diagnosed with nonpancreatic disease (NP) or AP. METHODS: Medical records were retrospectively reviewed, including diagnostic laboratory tests considered potentially useful in the diagnosis of AP...
January 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/26571807/-systemic-factors-of-acute-pancreatitis-advance
#15
G V Poryadin, A P Vlasov, S G Anasskin, T I Vlasova, I V Potynova, S A Turigina
In experimental studies the sequence of vitals series lesion is established at various forms of acute experimental pancreatitis (edematous pancreatitis, a pancreatonecrosis). It is shown that one of the first in pathological process involves an intestine, then - a liver, further - kidneys. It is established that at acute pancreatitis the basis of a target organs lesion is membranodestruktivny process due to excess activity of lipids peroxidation processes and phospholipase systems which are registered not only in a blood plasma, but also in tissue structures of the studied organs - an intestine, a liver, kidneys (systemic distress damages of oxidative and phospholipase induced character) acts...
April 2015: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/26427114/effect-of-chaiqinchengqi-decoction-on-inositol-requiring-enzyme-1%C3%AE-in-alveolar-macrophages-of-dogs-with-acute-necrotising-pancreatitis-induced-by-sodium-taurocholate
#16
Guo Jia, Wang Xiaoxiang, Luo Ruijie, Zhang Xiaoxin, Yang Xiaonan, Xia Qing, Xue Ping
OBJECTIVE: To investigate the effect of Chaiqinchengqi decoction (CQCQD) on inositol requiring enzyme lα (IRElα) in alveolar macrophages (AMs) of the dog model of acute necrotising pancreatitis (ANP) induced by sodium taurocholate. METHODS: Fifteen beagle dogs were randomised into a control group, ANP group and CQCQD group (n = 5 per group). ANP was induced by a retrograde duct injection of 50 mg/kg of 5% sodium taurocholate. The dogs in the control group received injections of the same volume of saline as the sodium taurocholate...
August 2015: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/26359725/canine-pancreas-specific-lipase-and-c-reactive-protein-in-dogs-treated-with-anticonvulsants-phenobarbital-and-potassium-bromide
#17
Viviana Albarracín, Mariana Teles, Antonio Meléndez-Lazo, Jaume Rodón, Josep Pastor
Animals treated with anticonvulsant drugs may have increased canine pancreas-specific lipase (cPLI) values. Inflammatory conditions and specifically acute pancreatitis are of major concern in these animals. Elevation in C-reactive protein is being associated with inflammatory status in dogs and it has been correlated with the clinical severity of pancreatitis. In the present study, we investigated if there is a correlation between the cPLI increase, changes in C-reactive protein and hepatic enzymes, as well as the incidence of severe acute pancreatitis (AP) in dogs with anticonvulsant treatment (phenobarbital, or potassium bromide or both)...
June 2015: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/26353468/pancreatic-polypeptide-a-review-of-its-involvement-in-neuro-endocrine-reflexes-islet-acinar-interactions-and-ethanol-evoked-physiopatologic-pancreatic-gland-changes
#18
REVIEW
Osvaldo Manuel Tiscornia, Gustavo Alberto Negri, Graciela Otero, Fabiana Norma López Mingorance, Hipólito Waisman, Patricia Graciela Tiscornia-Wasserman
prevents, in pancreocytes, the evolving of a "supramaximalecbolic-stimulation" process. The PP involvement as a modulating agent of pancreon's reactivity is reflected by the progressive increment of its plasma values in the first week of an evolving AP episode. In the AP associated to a large meal, an overpowering of the pancreon's brake might have a pivotal role. In experimental and clinical chronic alcoholism, a vagal neuropathy of the Pavlov inhibitory fibers that, as a consequence, impairs the pancreon's brake through a depression of PP secretion is at the basis of an enhanced reactivity of the duodeno-pancreatic reflexes...
June 2015: Acta Gastroenterologica Latinoamericana
https://www.readbyqxmd.com/read/26348466/pathophysiological-effects-of-pancreatic-sympathetic-denervation-in-acute-necrotizing-pancreatitis-in-dogs
#19
Junjun Sun, Shifang Qi, Weifeng Liu, Shiyong Xin, Yongchao Chang, Yanhui Yang, Liqing Zhou, Yuming Zhang, Zhijie Chu
OBJECTIVE: The aim of this study was to investigate the influence of the greater splanchnic nerve (GSN) transection on the pathophysiological process of acute necrotizing pancreatitis (ANP). METHODS: The dogs were divided into a sham operation (SO) group, ANP group, and ANP with bilateral GSN transection (GSNT) group. Dogs in the GSNT group underwent bilateral GSNT immediately after ANP induction. The levels of serum pancreatic amylase (AMY), calcium, high-sensitivity C-reactive protein (HCRP), tumor necrosis factor α (TNF-α), interleukin 10 (IL-10), and neutrophile granulocyte (NEU) counts were monitored dynamically, and the pathological examinations of the pancreas was performed at postoperative day 7...
October 2015: Pancreas
https://www.readbyqxmd.com/read/26332486/contrast-enhanced-ultrasonography-of-the-pancreas-in-healthy-dogs-and-in-dogs-with-acute-pancreatitis
#20
Nathalie Rademacher, David Schur, Frédéric Gaschen, Michael Kearney, Lorrie Gaschen
Pancreatitis is the most frequent disease affecting the exocrine pancreas in dogs and reliable diagnostic techniques for predicting fatal complications are lacking. Contrast-enhanced ultrasound (CEUS) improves detection of tissue perfusion as well as organ lesion vascular pattern. Objectives of this prospective case control study were to compare perfusion characteristics and enhancement patterns of the pancreas in healthy dogs and dogs with pancreatitis using CEUS. Ten healthy dogs and eight dogs with pancreatitis were selected based on physical examination, abdominal ultrasound, and blood analysis findings...
January 2016: Veterinary Radiology & Ultrasound
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