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https://www.readbyqxmd.com/read/29789104/functionalized-caprolactone-polyethylene-glycol-based-thermo-responsive-hydrogels-of-silibinin-for-the-treatment-of-malignant-melanoma
#1
Behzad Sharif Makhmalzadeh, Ommoleila Molavi, Mohammad Reza Vakili, Hai-Feng Zhang, Amir Solimani, Hoda Soleymani Abyaneh, Raimar Loebenberg, Raymond Lai, Afsaneh Lavasanifar
PURPOSE: Silibinin, is a natural compound, which has shown anticancer activity in various malignancies. In this study, we evaluated the anticancer effects of silibinin in B16-F10 melanoma cells and developed a novel thermoresponsive hydrogel for local delivery of this compound. METHOD: A thermoresponsive hydrogel loaded with silibinin was prepared using triblock copolymers of poly[(α-benzyl carboxylate-e-caprolactone)-co-(α-carboxyl-e-caprolactone)]ran-b-PEG-b-[(α-benzyl carboxylate-e-caprolactone) -co-(α-carboxyl-e-caprolactone)]ran (PCBCL-b-PEG-b-PCBCL), namely PolyGelTM, and compared with a Pluronic F-127 formulation of silibinin...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29785318/role-of-nanotechnology-in-cosmeceuticals-a-review-of-recent-advances
#2
REVIEW
Shreya Kaul, Neha Gulati, Deepali Verma, Siddhartha Mukherjee, Upendra Nagaich
Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have come into widespread use...
2018: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29785109/development-and-characterization-of-a-nanoemulsion-containing-propranolol-for-topical-delivery
#3
Tatiana Zanela da Silva Marques, Ralph Santos-Oliveira, Luciana Betzler de Oliveira de Siqueira, Verônica da Silva Cardoso, Zaida Maria Faria de Freitas, Rita de Cássia da Silva Ascenção Barros, Ana Lúcia Vazquez Villa, Mariana Sato de Souza de Bustamante Monteiro, Elisabete Pereira Dos Santos, Eduardo Ricci-Junior
Background: Propranolol (PPN) is a therapeutic option for the treatment of infantile hemangiomas. This study aimed at the development of nanoemulsion (NE) containing 1% PPN, characterization of the system, and safety studies based on ex vivo permeation, cytotoxicity, and biodistribution in vivo. Methods: The formulation was developed and characterized in relation to the droplet size, polydispersity index (PDI), pH, zeta potential, and electronic microscopy. Ex vivo permeation studies were used to evaluate the cutaneous retention of PPN in the epidermis and dermis...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29779482/nanocrystals-technology-for-transdermal-delivery-of-water-insoluble-drugs
#4
Yangyang Liu, Beibei Yan, Juan Zhao, Lulu Wang, Yu Gu, Ping Chang, Yancai Wang
The poor penetration and low bioavailability are main challenges for transdermal drug delivery. Nanocrystals technology is an attractive method for water insoluble drug transdermal delivery, as the literature demonstrated that the penetration and bioavailability of the transdermal delivered water insoluble drugs was significantly enhanced and improved by the nanocrystals technology. Currently, the nanocrystals technology has been applied in transdermal delivery of cosmeceutical and for therapy skin diseases, such as diclofenac acid, tretinoin and rutin...
May 18, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29777854/dissolving-polymeric-microneedle-arrays-for-enhanced-site-specific-acyclovir-delivery
#5
Boonnada Pamornpathomkul, Tanasait Ngawhirunpat, Ismaiel A Tekko, Lalitkumar Vora, Helen O McCarthy, Ryan F Donnelly
Acyclovir is widely indicated for the treatment of herpes labialis (cold sores), typically caused by the herpes simplex virus type 1 (HSV-1). However, topical acyclovir has poor efficacy, due to its low skin permeability. The purpose of this study was, therefore, to evaluate the ability of dissolving polymeric microneedle (MN) arrays to improve the local delivery of acyclovir. Acyclovir-loaded dissolving MN arrays (0.49 cm2 ) were formulated from aqueous blends of Gantrez® S-97 with 361 needles per array (589 ± 9...
May 16, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29775714/novel-bletilla-striata-polysaccharide-microneedles-fabrication-characterization-and-in-vitro-transcutaneous-drug-delivery
#6
Lingli Hu, Zhencheng Liao, Qiqi Hu, Katherine G Maffucci, Yan Qu
Dissolving microneedles (MNs) have been widely studied for their applications in effective transdermal drug delivery due to their ability to dissolve within the skin. This study details the first reported successful preparation of novel dissolving MNs using Bletilla striata polysaccharide (BSP), a natural glucomannan material, and investigates the potential for using such MNs as a transdermal drug delivery vector. The prepared dissolving Bletilla striata polysaccharide microneedles (BMNs) had excellent moldability and were easily detached from the mold...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775296/incorporation-of-a-theranostic-two-tone-luminescent-silver-complex-into-biocompatible-agar-hydrogel-composite-for-the-eradication-of-eskape-pathogens-in-a-skin-and-soft-tissue-infection-model
#7
Miguel N Pinto, Jorge Martinez-Gonzalez, Indranil Chakraborty, Pradip K Mascharak
Microbial invasion and colonization of the skin and underlying soft tissues are among the most common types of infections, becoming increasingly prevalent in hospital settings. Systemic antibiotic chemotherapies are now extremely limited due to emergence of drug-resistant Gram-positive and multidrug-resistant Gram-negative bacterial strains. Topical administration of antimicrobials provides an effective route for the treatment of skin and soft tissue infections (SSTIs). Therefore, the development of new and effective materials for the delivery of these agents is of paramount importance...
May 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29772224/pharmacokinetics-and-skin-tolerability-of-intracutaneous-zolmitriptan-delivery-in-swine-using-adhesive-dermally-applied-microarray-adam
#8
Joe Nguyen, Hayley Lewis, Ashley Queja, Anh Ngoc Diep, Guillaume Hochart, Mahmoud Ameri
Adhesive Dermally-Applied Microarray (ADAM) is a new drug delivery system that uses microprojections (340 μm long) for intracutaneous drug self-administration. We formulated zolmitriptan, a well-accepted and commonly used migraine medication, for administration using ADAM. In vivo studies were conducted in female prepubescent Yorkshire pigs using ADAM 1.9 mg zolmitriptan, applied to the inner thigh and left in place for 1 hour. Pharmacokinetic studies showed that the ADAM 1.9 mg zolmitriptan delivered with high efficiency (85%) and high absolute bioavailability (77%)...
May 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29771146/nanosized-ethanol-based-malleable-liposomes-of-cytarabine-to-accentuate-transdermal-delivery-formulation-optimization-in-vitro-skin-permeation-and-in-vivo-bioavailability
#9
Rakesh Raj, Pooja Mongia Raj, Alpana Ram
Cytarabine is a pyrimidine nucleoside analog used predominantly for acute myeloid leukemia (AML) and also for other indications, including acute lymphocytic leukemia, chronic myelogenous leukemia, and lymphoma by parenteral route due to its low oral bioavailability. Parenteral administration requires constant plasma level, monitoring for its fluctuation and poor patients compliances. Hence the objective of this work is to construct optimized nanosized malleable liposomes of cytarabine to accentuate transdermal delivery of drug to circumvent previously mentioned drawbacks...
May 17, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29768083/sebo-pharmacokinetics-a-proposed-percutaneous-sebum-egression-method
#10
Rasika Reddy, John Havens Cary, Akram Elmahdy, Howard Maibach
BACKGROUND/AIMS: The sebaceous gland is widely believed a critical factor in the pathogenesis of acne vulgaris. Although extensive studies document the ability of oral and topical treatments to improve acne, little is known about the quantification and mechanism of drug delivery via the sebaceous gland. A percutaneous egression method presents a way to study how drugs reaching the bloodstream can enter the skin. METHODS: A literature search was performed across databases (PubMed, Embase, and Google Scholar) and the University of California, San Francisco (UCSF) textbook library with relevant search terms...
May 16, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29766488/nanoemulsions-and-dermatological-diseases-contributions-and-therapeutic-advances
#11
REVIEW
Myla Lôbo de Souza, Douglas Dourado Oliveira, Neila de Paula Pereira, Denis Melo Soares
Skin disease is one of the most common human diseases and affects between 30% and 70% of individuals, which requires a lot of attention to their treatments. The delivery of active pharmacological ingredients at the topical level is a challenge because of the difficulties in overcoming the mechanical barrier created by the skin and reaching greater depths, since delivery specificities are decisive for the degree of effectiveness. In this way, the nanoemulsions emerge as a potential system for the incorporation of active substances in the cells and for the controlled release of active principles...
May 15, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29765638/porous-polymer-coatings-on-metal-microneedles-for-enhanced-drug-delivery
#12
Asad Ullah, Chul Min Kim, Gyu Man Kim
We present a simple method to coat microneedles (MNs) uniformly with a porous polymer (PLGA) that can deliver drugs at high rates. Stainless steel (SS) MNs of high mechanical strength were coated with a thin porous polymer layer to enhance their delivery rates. Additionally, to improve the interfacial adhesion between the polymer and MNs, the MN surface was modified by plasma treatment followed by dip coating with polyethyleneimine, a polymer with repeating amine units. The average failure load (the minimum force sufficient for detaching the polymer layer from the surface of SS) recorded for the modified surface coating was 25 N, whereas it was 2...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29753970/evaluation-of-aluminum-phthalocyanine-chloride-and-dna-interactions-for-the-design-of-an-advanced-drug-delivery-system-in-photodynamic-therapy
#13
Cristiano Ceron Jayme, Italo Rodrigo Calori, Elise Marques Freire Cunha, Antonio Claudio Tedesco
The aim of this study was to evaluate the interaction of aluminum phthalocyanine chloride (AlClPc) with double-stranded DNA. Absorption and fluorescence spectra, resonance light scattering, and circular dichroism were evaluated in water and water/ethanol mixtures with different concentrations of DNA or AlClPc. AlClPc showed a high ability to bind to DNA in both water and 4/6 water/ethanol mixture (v/v), with a majority of monomeric and aggregated initial forms of AlClPc, respectively. In this interaction, AlClPc bound preferentially to the grooves of DNA...
May 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29751264/rapid-thermal-responsive-conductive-hybrid-cryogels-with-shape-memory-properties-photothermal-properties-and-pressure-dependent-conductivity
#14
Zexing Deng, Yi Guo, Peter X Ma, Baolin Guo
Stimuli responsive cryogels with multi-functionality have potential application for electrical devices, actuators, sensors and biomedical devices. However, conventional thermal sensitive poly(N-isopropylacrylamide) cryogels show slow temperature response speed and lack of multi-functionality, which greatly limit their practical application. Herein we present conductive fast (2 min for both deswelling and reswelling behavior) thermally responsive poly(N-isopropylacrylamide) cryogels with rapid shape memory properties (3 s for shape recovery), near-infrared (NIR) light sensitivity and pressure dependent conductivity, and further demonstrated their applications as temperature sensitive on-off switch, NIR light sensitive on-off switch, water triggered shape memory on-off switch and pressure dependent device...
April 25, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29751143/characterization-and-cytotoxicity-evaluation-of-biocompatible-amino-acid-esters-used-to-convert-salicylic-acid-into-ionic-liquids
#15
Rahman Md Moshikur, Chowdhury Md Raihan, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto
The technological utility of active pharmaceutical ingredients (APIs) is greatly enhanced when they are transformed into ionic liquids (ILs). API-ILs have better solubility, thermal stability, and the efficacy in topical delivery than solid or crystalline drugs. However, toxicological issue of API-ILs is the main challenge for their application in drug delivery. To address this issue, 11 amino acid esters (AAEs) were synthesized and investigated as biocompatible counter cations for the poorly water-soluble drug salicylic acid (Sal) to form Sal-ILs...
May 8, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29750049/current-trends-in-needle-free-jet-injection-an-update
#16
REVIEW
Daniel Barolet, Antranik Benohanian
Background: Jet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin. Objective: The aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29745944/pegylated-graphene-oxide-mediated-quercetin-modified-collagen-hybrid-scaffold-for-enhancement-of-mscs-differentiation-potential-and-diabetic-wound-healing
#17
Jing Chu, Panpan Shi, Wenxia Yan, Jinping Fu, Zhi Yang, Chengmin He, Xiaoyuan Deng, Hanping Liu
Nanoscale delivery based on polyethylene glycol (PEG)ylated graphene oxide (GO-PEG) merits attention for biomedical applications owing to its functional surface modification, superior solubility/biocompatibility and controllable drug release capability. However, impaired skin regeneration in applications of these fascinating nanomaterials in diabetes is still limited, and critical issues need to be addressed regarding insufficient collagen hyperplasia and inadequate blood supply. Therefore, a high-performance tissue engineering scaffold with biocompatible and biodegradable properties is essential for diabetic wound healing...
May 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29743519/transdermal-water-in-oil-nanocarriers-of-nitric-oxide-for-triggering-penile-erection
#18
Eunryel Nam, Saejong Yoo, Hwi-Yool Kim, Young-Rok Kim, Yun Jung Heo
Men's sexual health can have significant effects on a man's self-esteem, sexual relationship and male reproductive functions. Although commercially available drugs (e.g., VIAGRA and CIALIS) show effective treatment of erectile dysfunction (ED), patients with severe ED fail to respond to these medicines. Topical nitric-oxide (NO) delivery to penis can be a painless, alternative solution with severe ED because NO triggers erection and diffuses to the trabecular arteries and smooth muscles in the penis. We here develop water-in-oil (W/O) nanoemulsions (NEs) that contain NO and can directly spread on the penis...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743505/contrasting-roles-for-actin-in-the-cellular-uptake-of-cell-penetrating-peptide-conjugates
#19
L He, E J Sayers, P Watson, A T Jones
The increased need for macromolecular therapeutics, such as peptides, proteins and nucleotides, to reach intracellular targets necessitates more effective delivery vectors and a higher level of understanding of their mechanism of action. Cell penetrating peptides (CPPs) can transport a range of macromolecules into cells, either through direct plasma membrane translocation or endocytosis. All known endocytic pathways involve cell-cortex remodelling, a process shown to be regulated by reorganisation of the actin cytoskeleton...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740759/characterization-and-in-vitro-permeation-study-of-cubic-liquid-crystal-containing-sinomenine-hydrochloride
#20
Xiaoqin Chu, Qian Li, Shuangying Gui, Zhengguang Li, Jiaojiao Cao, Jianqin Jiang
This study developed a new transdermal delivery system for the improved delivery of sinomenine hydrochloride (SH). The delivery system utilized the advantages of lyotropic liquid crystals (LLC) creating an adaptable system that offers a variety of options for the field of transdermal delivery. The formulation was prepared, characterized, and evaluated for its skin penetration in vitro. In the study, the appearance of samples was characterized by visual observation, and these LLC gels were colorless and transparent...
May 8, 2018: AAPS PharmSciTech
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