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https://www.readbyqxmd.com/read/28930588/nanoparticles-in-wound-healing-from-hope-to-promise-from-promise-to-routine
#1
Naghmeh Naderi, Dimitrios Karponis, Afshin Mosahebi, Alexander M Seifalian
Chronic non-healing wounds represent a growing problem due to their high morbidity and cost. Despite recent advances in wound healing, several systemic and local factors can disrupt the weighed physiologic healing process. This paper critically reviews and discusses the role of nanotechnology in promoting the wound healing process. Nanotechnology-based materials have physicochemical, optical and biological properties unique from their bulk equivalent. These nanoparticles can be incorporated into scaffolds to create nanocomposite smart materials, which promote wound healing through their antimicrobial, as well as selective anti- and pro-inflammatory, and pro-angiogenic properties...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929244/analyzing-polymeric-matrix-for-fabrication-of-a-biodegradable-microneedle-array-to-enhance-transdermal-delivery
#2
Kuo-Yuan Hwa, Vincent H S Chang, Yao-Yi Cheng, Yue-Da Wang, Pey-Shynan Jan, Boopathi Subramani, Min-Ju Wu, Bo-Kai Wang
Traditional drug delivery systems, using invasive, transdermal, and oral routes, are limited by various factors, such as the digestive system environment, skin protection, and sensory nerve stimulation. To improve the drug delivery system, we fabricated a polysaccharide-based, dissolvable microneedle-based array, which combines the advantages of both invasive and transdermal delivery systems, and promises to be an innovative solution for minimally invasive drug delivery. In this study, we designed a reusable aluminum mold that greatly improved the efficiency and convenience of microneedle fabrication...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28925887/design-optimize-and-characterize-granisetron-hcl-loaded-nano-gel-for-transdermal-delivery
#3
Vikash Kumar, Hema Chaudhary, Geeta Aggarwal
The aim of study was to design, statistically optimize and characterize Granisetron HCl loaded transfersomal gel for transdermal delivery, in order to overcome the side effects associated with oral delivery. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipid-90G, sodium deoxycholate and sonication time, each at three levels, were selected as independent variables, and while entrapment efficiency, vesicle size and transdermal flux were identified as dependent variables...
September 15, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28922374/fractional-laser-exposure-induces-neutrophil-infiltration-n1-phenotype-into-the-tumor-and-stimulates-systemic-anti-tumor-immune-response
#4
Masayoshi Kawakubo, Shadmehr Demehri, Dieter Manstein
BACKGROUND: Ablative fractional photothermolysis (aFP) using a CO2 laser generates multiple small diameter tissue lesions within the irradiation field. aFP is commonly used for a wide variety of dermatological indications, including treatment of photodamaged skin and dyschromia, drug delivery and modification of scars due to acne, surgical procedures and burns. In this study we explore the utility of aFP for treating oncological indications, including induction of local tumor regression and inducing anti-tumor immunity, which is in marked contrast to current indications of aFP...
2017: PloS One
https://www.readbyqxmd.com/read/28917990/glycerosomes-investigation-of-role-of-1-2-dimyristoyl-sn-glycero-3-phosphatidycholine-dmpc-on-the-assembling-and-skin-delivery-performances
#5
Maria Letizia Manca, Maria Manconi, Marco Zaru, Donatella Valenti, Jose Esteban Peris, Pietro Matricardi, Anna Maria Maccioni, Anna Maria Fadda
Glycerosomes were formulated using 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC), diclofenac sodium salt and 10, 20 or 30% glycerol in the water phase, while corresponding liposomes were prepared with the same amount of DMPC and diclofenac, without glycerol. The aim of the present work was to evaluate the effect of the used phospholipid on vesicle features and ability to favour diclofenac skin deposition by comparing these results with those found in previous works performed using hydrogenated soy phosphatidylcholine (P90H) and dipalmitoylphosphatidylcholine (DPPC)...
September 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28917926/bioadhesive-and-biocompatible-films-as-wound-dressing-materials-based-on-a-novel-dendronized-chitosan-loaded-with-ciprofloxacin
#6
Mónica C García, Ana A Aldana, Luis I Tártara, Fabiana Alovero, Miriam C Strumia, Rubén H Manzo, Marisa Martinelli, Alvaro F Jimenez-Kairuz
The bioadhesive polymeric films as topical drug delivery systems are interesting alternatives to improve the pharmacotherapy and patient compliances. New derivate biomaterials based on weisocyanate- dendronized PVP- crosslinked chitosan and loaded with ciprofloxacin (CIP), as model drug, were used to prepare bioadhesive films. Relevant in vitro/in vivo attributes to define main physicochemical and biopharmaceutical characteristics for topical wound-healing applications were evaluated. A high proportion of CIP, uniformly dispersed along throughout the film, was loaded...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917384/serious-infections-among-a-large-cohort-of-subjects-with-systemically-treated-psoriasis
#7
Allison S Dobry, Charles P Quesenberry, G Thomas Ray, Jamie L Geier, Maryam M Asgari
BACKGROUND: Biologic therapy is effective for treatment of moderate-to-severe psoriasis but may be associated with an increased risk for serious infection. OBJECTIVE: To estimate the serious infection rate among patients with psoriasis treated with biologic as compared with nonbiologic systemic agents within a community-based health care delivery setting. METHODS: We identified 5889 adult Kaiser Permanente Northern California health plan members with psoriasis who had ever been treated with systemic therapies and calculated the incidence rates and 95% confidence intervals (CIs) for serious infections over 29,717 person-years of follow-up...
September 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28916504/going-skin-deep-a-direct-comparison-of-penetration-potential-of-lipid-based-nanovesicles-on-the-isolated-perfused-human-skin-flap-model
#8
Selenia Ternullo, Louis de Weerd, Ann Mari Holsæter, Gøril Eide Flaten, Nataša Škalko-Basnet
Phospholipid-based nanocarriers are attractive drug carriers for improved local skin therapy. In the present study, the recently developed isolated perfused human skin flap (IPHSF) model was used to directly compare the skin penetration enhancing potential of the three commonly used nanocarriers, namely conventional liposomes (CLs), deformable liposomes (DLs) and solid lipid nanoparticles (SLNs). Two fluorescent markers, calcein (hydrophilic) or rhodamine (lipophilic), were incorporated individually in the three nanosystems...
September 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28915288/successful-treatment-of-keloid-with-fractionated-carbon-dioxide-co2-laser-and-laser-assisted-drug-delivery-of-triamcinolone-acetonide-ointment-in-an-african-american-man
#9
Ekaterina Kraeva, Derek Ho, Jared Jagdeo
Keloids are fibrous growths that occur as a result of abnormal response to dermal injury. Keloids are cosmetically disfiguring and may impair function, often resulting in decreased patient quality-of-life. Treatment of keloids remains challenging, and rate of recurrence is high. We present a case of a 39-year-old African-American man (Fitzpatrick VI) with a 10-year history of keloid, who was successfully treated with eight sessions of fractionated carbon dioxide (CO2) laser immediately followed by laser-assisted drug delivery (LADD) of topical triamcinolone acetonide (TAC) ointment and review the medical literature on fractionated CO2 laser treatment of keloids...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28913392/data-on-scaling-up-and-in-vivo-human-study-of-progesterone-lipid-nanoparticles
#10
Elisabetta Esposito, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Claudio Nastruzzi, Rita Cortesi
Progesterone containing nanoparticles constituted of tristearin or tristearin in association with caprylic-capric triglyceride were produced in a lab scale by ultrasound homogenization and in a pilot scale by high pressure homogenization. A study was conducted to select the pressure to be used in order to obtain homogenously sized nanoparticles. The Dialysis method was performed to mimic subcutaneous administration of lipid nanoparticles. Mathematical analyses of the results were conducted to understand and compare the drug release mechanisms...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28904933/electrospun-gelatin-poly-glycerol-sebacate-membrane-with-controlled-release-of-antibiotics-for-wound-dressing
#11
Parisa Shirazaki, Jaleh Varshosaz, Anoushe Zargar Kharazi
BACKGROUND: The most important risk that threatens the skin wounds is infections. Therefore, fabrication of a membrane as a wound dressing with the ability of antibiotic delivery in a proper delivery rate is especially important. MATERIALS AND METHODS: Poly(glycerol sebacate) (PGS) was prepared from sebacic acid and glycerol with 1:1 ratio; then, it was added to gelatin in the 1:3 ratio and was dissolved in 80% (v/v) acetic acid, and finally, ciprofloxacin was added in 10% (w/v) of polymer solution...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28899209/microneedle-mediated-transdermal-delivery-of-nanostructured-lipid-carriers-for-alkaloids-from-aconitum-sinomontanum
#12
Teng Guo, Yongtai Zhang, Zhe Li, Jihui Zhao, Nianping Feng
A combination method using microneedle (MN) pretreatment and nanostructured lipid carriers (NLCs) was developed to improve the transdermal delivery of therapeutics. The MN treatment of the skin and co-administration of NLCs loaded with total alkaloids isolated from Aconitum sinomontanum (AAS-NLCs) significantly increased the skin permeation of the drugs. Fluorescence imaging confirmed that MNs could provide microchannels penetrating the stratum corneum, and delivery of NLCs through the channels led to their deeper permeation...
September 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28895213/supramolecular-synthon-approach-in-developing-anti-inflammatory-topical-gel-for-in-vivo-self-delivery
#13
Parthasarathi Dastidar, Rajdip Roy
A new series of TBA salt of various non-steroidal-anti-inflammatory-drugs (NSAIDs) was synthesized and characterized. Nearly 90% of the salts displayed remarkable gelation ability with various solvents including methyl salicylate. SXRD revealed the existence of 1D PAM synthon in the gelator salts. Structure-property correlation studies based on SXRD and PXRD data established the presence of the 1D PAM synthon in the bulk salts as well as in the corresponding xerogels. A parallel series of salts derived from TRIS and the same set of NSAIDs displayed poor gelation ability (only 33% of the salts)...
September 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28887345/design-and-implementation-of-population-based-specialty-care-programs
#14
Sheila R Botts, Michael T Gee, Christopher C Chang, Iris Young, Logan Saito, Alfred E Lyman
PURPOSE: The development, implementation, and scaling of 3 population-based specialty care programs in a large integrated healthcare system are reviewed, and the role of clinical pharmacy services in ensuring safe, effective, and affordable care is highlighted. SUMMARY: The Kaiser Permanente (KP) integrated healthcare delivery model allows for rapid development and expansion of innovative population management programs involving pharmacy services. Clinical pharmacists have assumed integral roles in improving the safety and effectiveness of high-complexity, high-cost care for specialty populations...
September 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28870768/sponge-like-microparticles-for-drug-delivery-and-cosmeto-textile-use-formulation-and-human-skin-penetration
#15
Nadiah Zafar, Sophie Robin, Céline Viennet, Philippe Humbert, Jean Pierre Valour, Geraldine Agusti, Hatem Fessi, Abdelhamid Elaissari
This unique work is targeted to achieve three main goals: i) to enhance the aqueous solubility of three specifically selected hydrophobic active agents, ii) to prepare such polymeric biodegradable microparticles which can encapsulate actives-cyclodextrin complexes and iii) to functionalize a polyamide base textile with active loaded microparticles and active-cyclodextrin loaded microparticles. To achieve this objective, biodegradable cationic microparticles were prepared via double emulsion solvent evaporation process and were loaded with hydroxypropyl-beta-cyclodextrin based complexes of Indomethacin, α-tocopheroland Lauryl Isoquinolinium Bromide during the formulation process...
September 1, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28867296/device-assisted-transdermal-drug-delivery
#16
Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
Transdermal drug delivery is a prospective drug delivery strategy to complement the limitations of conventional drug delivery systems including oral and injectable methods. This delivery route allows both convenient and painless drug delivery and a sustained release profile with reduced side effects. However, physiological barriers in the skin undermine the delivery efficiency of conventional patches, limiting drug candidates to small-molecules and lipophilic drugs. Recently, transdermal drug delivery technology has advanced from unsophisticated methods simply relying on natural diffusion to drug releasing systems that dynamically respond to external stimuli...
September 1, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28865318/preparation-and-characterization-of-fe3o4-ag2o-quantum-dots-decorated-cellulose-nanofibers-as-a-carrier-of-anticancer-drugs-for-skin-cancer
#17
Ali Fakhri, Shiva Tahami, Pedram Afshar Nejad
The Best performance drug delivery systems designed with Fe3O4-Ag2O quantum dots decorated cellulose nanofibers which that grafted with Etoposide and Methotrexate. Morphology properties were characterized by Scanning and Transmittance electron microscopy. The crystalline structure of prepared sample was evaluated using by X-ray diffraction. The vibrating sample magnetometer analysis was used for magnetic behavior of samples. The size distributions of Fe3O4-Ag2O QDs/Cellulose fibers nanocomposites indicate that the average diameter was 62...
August 24, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28865105/minimally-invasive-and-targeted-therapeutic-cell-delivery-to-the-skin-using-microneedle-devices
#18
B Gualeni, S A Coulman, D Shah, P F Eng, H Ashraf, P Vescovo, G J Blayney, L-D Piveteau, O J Guy, J C Birchall
BACKGROUND: Translation of cell therapies to the clinic is accompanied by numerous challenges, including controlled and targeted delivery of the cells to their site of action, without compromising cell viability and functionality. OBJECTIVES: To explore the use of hollow microneedle devices (to date only used for the delivery of drugs and vaccines into the skin and for the extraction of biological fluids) to deliver cells into skin in a minimally-invasive, user-friendly and targeted fashion...
September 2, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28860829/erratum-cefazolin-potency-against-methicillin-resistant-staphylococcus-aureus-a-microbiologic-assessment-in-support-of-a-novel-drug-delivery-system-for-skin-and-skin-structure-infections-erratum
#19
(no author information available yet)
[This corrects the article on p. 227 in vol. 10, PMID: 28794647.].
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28858661/skin-permeability-and-transdermal-delivery-route-of-50-nm-indomethacin-loaded-plga-nanoparticles
#20
Issei Takeuchi, Takaaki Suzuki, Kimiko Makino
Recently, nano-seized systems for transdermal delivery have attracted attention. To efficiently deliver drugs to hair follicles, we focused on poly(DL-lactide-co-glycolide) (PLGA) nanoparticles prepared using a combination of an antisolvent diffusion method with preferential solvation. The PLGA nanoparticles prepared using this method are suitable for iontophoresis because of their high surface charge number density. It has been reported that PLGA nanoparticles were delivered to hair follicles by applying iontophoresis, however research on PLGA nanoparticles with a size of less than 100nm was lacking...
August 4, 2017: Colloids and Surfaces. B, Biointerfaces
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