keyword
MENU ▼
Read by QxMD icon Read
search

Drug delivery skin

keyword
https://www.readbyqxmd.com/read/28432615/fabrication-physicochemical-characterization-and-performance-evaluation-of-biodegradable-polymeric-microneedle-patch-system-for-enhanced-transcutaneous-flux-of-high-molecular-weight-therapeutics
#1
Viral Shah, Bijaya Krushna Choudhury
A revolutionary paradigm shift is being observed currently, towards the use of therapeutic biologics for disease management. The present research was focused on designing an efficient dosage form for transdermal delivery of α-choriogonadotropin (high molecular weight biologic), through biodegradable polymeric microneedles. Polyvinylpyrrolidone-based biodegradable microneedle arrays loaded with high molecular weight polypeptide, α-choriogonadotropin, were fabricated for its systemic delivery via transdermal route...
April 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28429293/topical-delivery-of-fenoprofen-calcium-via-elastic-nano-vesicular-spanlastics-optimization-using-experimental-design-and-in-vivo-evaluation
#2
Dalia Ali Farghaly, Ahmed A Aboelwafa, Manal Y Hamza, Magdy I Mohamed
The aim of this study was to investigate the potential of surfactant-based nanovesicular system (spanlastics) for topical delivery of fenoprofen calcium (FPCa) to eliminate its oral gastrointestinal adverse effects. FPCa-loaded spanlastics were prepared by thin film hydration (TFH) technique according to a full factorial design to investigate the influence of formulation variables on the drug entrapment efficiency (%EE), particle size (PS), deformability index (DI), and the % drug released after 24 h through the cellulose membrane (Q24h) using Design-Expert® software...
April 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28428089/enhanced-anti-rheumatic-activity-of-methotrexate-entrapped-ultradeformable-liposomal-gel-in-adjuvant-induced-arthritis-rat-model
#3
Alam Zeb, Omer Salman Qureshi, Chan-Hee Yu, Muhammad Akram, Hyung-Seo Kim, Myung-Sic Kim, Jong-Ho Kang, Arshad Majid, Sun-Young Chang, Ok-Nam Bae, Jin-Ki Kim
The aim of this study is to investigate in vivo anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel (MTX-UDLs-gel) in adjuvant-induced arthritis rat model. Methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) with the optimal phosphatidylcholine to Tween 80 ratio (7:3, w/w) were incorporated into 1% Carbopol gel. MTX-UDLs-gel was characterized in terms of appearance, clarity, homogeneity, pH and drug content. The permeation of MTX-UDLs-gel across rat skin was investigated using Franz diffusion cell...
April 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28428067/targeting-and-synergistic-action-of-an-antifungal-peptide-in-an-antibiotic-drug-delivery-system
#4
Seong-Cheol Park, Young-Min Kim, Jong-Kook Lee, Nam-Hong Kim, Eun-Ji Kim, Hun Heo, Min-Young Lee, Jung Ro Lee, Mi-Kyeong Jang
Amphotericin B (AmB) has been widely used against fungal infections throughout almost the entire body, including the skin, nails, oral cavity, respiratory tract, and urinary tract. However, the development of AmB-loaded nanoparticles demands a novel technique that reduces its toxicity and other associated problems. Here, we developed a pH-responsive and redox-sensitive polymer-based AmB-delivery carrier system. In particular, this system was functionalized by conjugation with the antifungal peptide histatin 5, which acts both as a targeting ligand and a synergistic antifungal molecule against Candida albicans, a major systemic fungal pathogen of humans...
April 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28426265/transdermal-iontophoresis-patch-with-reverse-electrodialysis
#5
Joon Lee, Kilsung Kwon, Minyoung Kim, Joonhong Min, Nathaniel S Hwang, Won-Serk Kim
Reverse electrodialysis (RED) technology generates energy from the salinity gradient by contacting waters with different salinity. Herein, we develop the disposable skin patch using this eco-friendly energy. The current density, which can be controlled easily without special circuit, is enough to iontophoretic drug delivery. In vitro study, this iontophoretic system enhanced the transdermal delivery of peptide, which is difficult to penetrate the skin barrier by simple diffusion. We design the disposable iontophoretic skin patch using RED system and suggest this patch can be apply on new cosmetic patch or disposable drug patch...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28423970/recent-advances-on-topical-antimicrobials-for-skin-and-soft-tissue-infections-and-their-safety-concerns
#6
P L Lam, K K H Lee, R S M Wong, G Y M Cheng, Z X Bian, C H Chui, R Gambari
Antimicrobial resistance of disease-related microorganisms is considered a worldwide prevalent and serious issue which increases the failure of treatment outcomes and leads to high mortality. Considering that the increased resistance to systemic antimicrobial therapy often needs of the use of more toxic agents, topical antimicrobial therapy emerges as an attractive route for the treatment of infectious diseases. The topical antimicrobial therapy is based on the absorption of high drug doses in a readily accessible skin surface, resulting in a reduction of microbial proliferation at infected skin sites...
April 19, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28422484/direct-synthesis-of-dextran-based-antibacterial-hydrogels-for-extended-release-of-biocides-and-eradication-of-topical-biofilms
#7
Jiaul Hoque, Jayanta Haldar
Cationic small molecular biocides have been developed as promising antibiofilm agents because of their tunability in chemical structures and ability to disrupt established biofilms. However, the impact of biocides in antibiofilm treatment is largely limited due to lack of an effective delivery system that can ensure sustained release of biocide at the target site. Herein we report biocide-encapsulated antibacterial and antibiofilm hydrogel that acts as efficient delivery vehicle for the biocide and eradicates matured bacterial biofilm...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28420295/optimization-of-methotrexate-loaded-niosomes-by-box-behnken-design-an-understanding-of-solvent-effect-and-formulation-variability
#8
Ahmed S Zidan, Mahmoud Mokhtar Ibrahim, Nagia A El Megrab
Dermal drug delivery system which localizes methotrexate (MTX) in the skin is advantageous in topical treatment of psoriasis. The aim of the current study was to understand dilution effects and formulation variability for the potential formation of niosomes from proniosome gels of MTX. Box-Behenken design was employed to prepare a series of MTX proniosome gels of Span 40, cholesterol (Chol-X1) and Tween 20 (T20-X2). Short chain alcohols (X3), namely ethanol (Et), propylene glycol (Pg) and glycerol (G) were evaluated for their dilution effects on proniosomes...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28420288/microemulsion-loaded-hydrogel-as-a-promising-vehicle-for-dermal-delivery-of-the-antifungal-sertaconazole-design-optimization-and-ex-vivo-evaluation
#9
Shaimaa Ali Ali Radwan, Aliaa Nabil ElMeshad, Raguia Aly Shoukri
The purpose of the present study was to develop and optimize sertaconazole microemulsion-loaded hydrogel (STZ ME G) to enhance the dermal delivery and skin retention of the drug. Following screening of various oils for maximum drug solubility, twelve pseudoternary phase diagrams were constructed using oils (Peceol®, Capryol(®) 90), surfactants (Tween(®) 80, Cremophor(®) EL), a cosurfactant (Transcutol(®) P) and water. A 2(1)x 3(1)x 2(1)x 3(1) full factorial design was employed to optimize a ME of desirable characteristics...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28419941/pamam-generation-4-incorporated-gelatin-3d-matrix-as-an-improved-dermal-substitute-for-skin-tissue-engineering
#10
Somnath Maji, Tarun Agarwal, Tapas Kumar Maiti
The study explored the prospects of PAMAM (generation 4) applicability in gelatin based scaffolds for skin tissue engineering. The effect of PAMAM on physico-chemical and biological characteristics of gelatin scaffolds was evaluated. Gelatin scaffolds (with/without PAMAM) were prepared by lyophilization, chemically crosslinked by glutaraldehyde and characterized for their morphology (pore size), chemical features (bond nature), water adsorption, biodegradation and biological compatibility. The study demonstrated that addition of PAMAM did not significantly alter the pore size distribution or porosity of the scaffolds...
April 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28415407/formulation-by-design-based-risperidone-nano-soft-lipid-vesicle-as-a-new-strategy-for-enhanced-transdermal-drug-delivery-in-vitro-characterization-and-in-vivo-appraisal
#11
Syed Sarim Imam, Abdul Ahad, Mohammed Aqil, Mohd Akhtar, Yasmin Sultana, Asgar Ali
The present study was designed to formulate and optimize transdermal risperidone soft lipid vesicles. The formulation optimized with phospholipid, safranal and ethanol were incorporated as permeation and absorption enhancers. The optimized risperidone soft lipid vesicle was further evaluated for skin irritation study, in-vivo pharmacokinetic study and locomotor activity. Three factor three level Box-Behnken design (BBD) was used to statistically optimize soft lipid vesicle using safranal (A), ethanol (B)and phospholipid (C) as independent variable, while their effect was observed for vesicle size (Y1), entrapment efficiency (Y2) and flux (Y3)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28411641/nanoarmoring-of-proteins-by-conjugation-to-block-copolymer-micelles
#12
Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan
The creation of polymer nanoparticles with protein functionality is of great interest to many applications such as targeted drug or gene delivery, diagnostic imaging, cancer theranostics, delivery of protein therapeutics, sensing chemical and biomolecular analytes in complex environments, and design of protective clothing resembling a second skin. Many approaches to achieving this goal are being explored in the current literature. In this chapter, we describe a relatively simple and flexible approach of conjugating the protein to an amphiphilic block copolymer and creating polymer nanoparticles with protein functionality by taking advantage of the intrinsic self-assembly behavior of the amphiphilic block copolymer...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28411333/technological-device-for-manufacturing-transdermal-films-possible-applications-to-the-individualized-treatment-for-erectile-dysfunction
#13
Francisco José Raposo, Hudson Caetano Polonini, Anderson Ferreira, Nádia Rezende Barbosa Raposo, Marcos Antônio Fernandes Brandão
Pharmacological advances in erectile dysfunction (ED) treatment have aroused growing interest among health professionals towards sexual dysfunction, generating an increasing demand for dosage forms and drug delivery systems, including tadalafil. This study aimed to develop a device to generate patches that would enable drug dosage individualization and transdermal administration. To create such a mechanical device, technical drawings were made using the CAD software. A functional prototype was built, and a pharmaceutical formulation containing tadalafil (10 mg cm(-2)) was prepared...
April 14, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28411056/development-and-evaluation-of-resveratrol-vitamin-e-and-epigallocatechin-gallate-loaded-lipid-nanoparticles-for-skin-care-applications
#14
Jin Chen, Ning Wei, Maria Lopez-Garcia, Dianna Ambrose, Jason Lee, Colin Annelin, Teresa Peterson
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been studied as potential carriers for both dermal and transdermal drug delivery. SLN contain lipid droplets that are fully crystallized and have a highly-ordered crystalline structure. NLC are modified SLN in which the lipid phase contains both solid and liquid lipids at room temperature. SLN and NLC are thought to combine the advantages of polymeric particles, liposomes and emulsions. Therefore they provide high encapsulation percentages, better protection for incorporated actives and allow for control of desired release profile...
April 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28405912/continuous-transdermal-delivery-of-l-dopa-based-on-a-self-assembling-nanomicellar-system
#15
Amnon C Sintov, Haim V Levy, Igor Greenberg
PURPOSE: When levodopa (L-DOPA) is administered orally, it is eliminated from the body very quickly resulting in a series of sharp fluctuations in its blood concentrations. These frequent changes in blood levels are considered to be responsible for the development of late motor complications and dyskinesias, which are troubling clinical and treatment issues in Parkinson's disease. Transdermal drug delivery is a patient-compliant method for delivering therapeutics into the systemic circulation in a continuous and controlled manner...
April 12, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28405574/formulation-and-evaluation-of-transdermal-drug-delivery-of-topiramate
#16
Suneetha Cherukuri, Uma Rajeswari Batchu, Kiranmai Mandava, Vidhyullatha Cherukuri, Koteswara Rao Ganapuram
BACKGROUND: Transdermal drug delivery system (TDDS) was designed to sustain the release and improve the bioavailability of drug and patient compliance. Among the various types of transdermal patches, matrix dispersion type systems disperse the drug in the solvent along with the polymers and solvent is allowed to evaporate forming a homogeneous drug-polymer matrix. The objective of the present study was to design and formulate TDDS of topiramate (TPM) and to evaluate their extended release in vitro and ex vivo...
January 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28403666/enhanced-acyclovir-delivery-using-w-o-type-microemulsion-preclinical-assessment-of-antiviral-activity-using-murine-model-of-zosteriform-cutaneous-hsv-1-infection
#17
Amanpreet Kaur, Gajanand Sharma, Vishal Gupta, Radha Kanta Ratho, Om Prakash Katare
The present study was aimed to develop and evaluate a microemulsion-based dermal drug delivery of an antiviral agent, acyclovir. A water-in-oil microemulsion was prepared using isopropyl myristate, Tween 20, Span 20, water and dimethylsulphoxide. It was characterized for drug content, stability, globule size, pH, viscosity and ex vivo permeation through mice skin. In vivo antiviral efficacy of optimized formulation was assessed in female Balb/c mice against herpes simplex virus-I (HSV-I)-induced infection. It was observed that optimized formulation when applied 24-h post-infection could completely inhibit the development of cutaneous herpetic lesions vis-à-vis marketed cream...
April 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28403263/microneedling-in-all-skin-types-a-review
#18
Lauren Meshkov Bonati, Gorana Kuka Epstein, Tamara Lazic Strugar
<p>INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.</p> <p>METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Search terms included: "microneedling," "percutaneous collagen induction," "needling," "skin needling," and "dermaroller...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28400291/unmet-clinical-needs-in-the-treatment-of-systemic-fungal-infections-the-role-of-amphotericin-b-and-drug-targeting
#19
Raquel Fernández-García, Esther de Pablo, María Paloma Ballesteros, Dolores R Serrano
Recently an increase in both the prevalence and incidence of invasive fungal infections have been reported. The number of fungal species that can cause systemic mycoses are higher and current antifungal therapies are still far from ideal. The emergence of antifungal resistances has a major clinical impact when using azoles and echinocandins leading to possible treatment failure and ultimately putting the patient's life at risk. Amphotericin B can play a key role in treating severe invasive mycoses as the incidence of antifungal resistance is very low combined with a high efficacy against a wide range of fungi...
April 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28393568/assessment-of-radical-scavenging-whitening-and-moisture-retention-activities-of-panax-ginseng-berry-mediated-gold-nanoparticles-as-safe-and-efficient-novel-cosmetic-material
#20
Zuly Jiménez, Yeon-Ju Kim, Ramya Mathiyalagan, Kwang-Hoon Seo, Padmanaban Mohanan, Jong-Chan Ahn, Yu-Jin Kim, Deok Chun Yang
Panax ginseng berry extract possess remarkable pharmacological effects on skin treatment such as anti-aging, antioxidant, promotor of collagen synthesis and alleviation against atopic dermatitis. In recent years, gold nanoparticles have gained much attention due to their extensive range of applications in particular in the field of drug delivery as a result of their biological compatibility and low toxicity. In a previous study, we designed and developed biocompatible gold and silver nanoparticles based on phytochemical profile and pharmacological efficacy of P...
April 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
keyword
keyword
107482
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"