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https://www.readbyqxmd.com/read/28917531/hollow-microneedle-mediated-intradermal-delivery-of-model-vaccine-antigen-loaded-plga-nanoparticles-elicits-protective-t-cell-mediated-immunity-to-an-intracellular-bacterium
#1
Anne Marit de Groot, Guangsheng Du, Juha Mönkäre, Anouk C M Platteel, Femke Broere, Joke A Bouwstra, Alice J A M Sijts
The skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles with and without TLR3 agonist poly(I:C) were prepared and administered intradermally by hollow microneedles. The capacity of the PLGA nanoparticles to induce a cytotoxic T cell response, contributing to protection against intracellular pathogens, was examined...
September 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28915391/hepatitis-b-surface-antigen-incorporated-in-dissolvable-microneedle-array-patch-is-antigenic-and-thermostable
#2
Danielle Poirier, Frédéric Renaud, Vincent Dewar, Laurent Strodiot, Florence Wauters, Jim Janimak, Toshio Shimada, Tatsuya Nomura, Koki Kabata, Koji Kuruma, Takayuki Kusano, Masaki Sakai, Hideo Nagasaki, Takayoshi Oyamada
Alternatives to syringe-based administration are considered for vaccines. Intradermal vaccination with dissolvable microneedle arrays (MNA) appears promising in this respect, as an easy-to-use and painless method. In this work, we have developed an MNA patch (MNAP) made of hydroxyethyl starch (HES) and chondroitin sulphate (CS). In swines, hepatitis B surface antigen (HBsAg) formulated with the saponin QS-21 as adjuvant, both incorporated in HES-based MNAP, demonstrated the same level of immunogenicity as a commercially available aluminum-adjuvanted HBsAg vaccine, after two immunizations 28 days apart...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28899209/microneedle-mediated-transdermal-delivery-of-nanostructured-lipid-carriers-for-alkaloids-from-aconitum-sinomontanum
#3
Teng Guo, Yongtai Zhang, Zhe Li, Jihui Zhao, Nianping Feng
A combination method using microneedle (MN) pretreatment and nanostructured lipid carriers (NLCs) was developed to improve the transdermal delivery of therapeutics. The MN treatment of the skin and co-administration of NLCs loaded with total alkaloids isolated from Aconitum sinomontanum (AAS-NLCs) significantly increased the skin permeation of the drugs. Fluorescence imaging confirmed that MNs could provide microchannels penetrating the stratum corneum, and delivery of NLCs through the channels led to their deeper permeation...
September 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28892233/hyaluronic-acid-microneedle-patch-for-the-improvement-of-crow-s-feet-wrinkles
#4
Sun Young Choi, Hyun Jung Kwon, Ga Ram Ahn, Eun Jung Ko, Kwang Ho Yoo, Beom Joon Kim, Changjin Lee, Daegun Kim
Hyaluronic acid (HA) has an immediate volumizing effect, due to its strong water-binding potential, and stimulates fibroblasts, causing collagen synthesis, with short- and long-term effects on wrinkle improvement. We investigated the efficacy and safety of HA microneedle patches for crow's feet wrinkles. Using a randomized spilt-face design, we compared microneedle patches with a topical application containing the same active ingredients. We enrolled 34 Korean female subjects with mild to moderate crow's feet wrinkles...
September 11, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28881348/accelerating-topical-anaesthesia-using-microneedles
#5
Lleucu B Davies, Christopher Gateley, Phillip Holland, Siôn A Coulman, James C Birchall
BACKGROUND/AIMS: Topical anaesthetics reduce pain during venous access procedures in children. However, clinical use is hindered by a significant anaesthetic onset time. Restricted diffusion of the topical anaesthetic through the stratum corneum barrier is the principal reason for the delayed onset. Microneedles can painlessly pierce the skin. This study evaluated microneedle pre-treatment of ex vivo human skin as a means to increase the rate of tetracaine permeation, in order to accelerate the onset of anaesthesia...
September 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28869385/microneedling-a-form-of-collagen-induction-therapy-our-first-experiences
#6
H Šuca, R Zajíček, Z Vodsloň
INTRODUCTION: Microneedling (percutaneous collagen induction therapy) is a new promising miniinvasive therapeutic method for the treatment of skin alterations of different aetiology, including burn scars. Since 2016, it is also available at our department. The microtraumatization of scars with the Dermaroller® leads to an activation of the healing cascade, activation of growth factors, which activate cell proliferation in the wound, increased synthesis and deposit of collagen - elastin complex with successive transformation of collagen III to collagen I, to neoangiogenesis and thus to accelerated scar remodelling...
2017: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/28867811/development-and-evaluation-of-topical-gabapentin-formulations
#7
Christopher J Martin, Natalie Alcock, Sarah Hiom, James C Birchall
Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol(®) hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm(®) formulation; furthermore microneedle facilitated delivery was used as a positive control...
August 30, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28867296/device-assisted-transdermal-drug-delivery
#8
Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
Transdermal drug delivery is a prospective drug delivery strategy to complement the limitations of conventional drug delivery systems including oral and injectable methods. This delivery route allows both convenient and painless drug delivery and a sustained release profile with reduced side effects. However, physiological barriers in the skin undermine the delivery efficiency of conventional patches, limiting drug candidates to small-molecules and lipophilic drugs. Recently, transdermal drug delivery technology has advanced from unsophisticated methods simply relying on natural diffusion to drug releasing systems that dynamically respond to external stimuli...
September 1, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28866156/polymer-microneedles-fabricated-from-alginate-and-hyaluronate-for-transdermal-delivery-of-insulin
#9
Weijiang Yu, Guohua Jiang, Yang Zhang, Depeng Liu, Bin Xu, Junyi Zhou
To reduce the inconvenient and painful of subcutaneous needle injection, the polymer microneedle patches that fabricated from modified alginate and hyaluronate were prepared for transdermal delivery of insulin. The as-prepared microneedles (MNs) exhibited excellent mechanical strength to penetrate the skin and good degradability to release loaded insulin. In vitro skin insertion capability was determined by staining with tissue-marking dye after insertion, and the real-time penetration depth was monitored using optical coherence tomography...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865105/minimally-invasive-and-targeted-therapeutic-cell-delivery-to-the-skin-using-microneedle-devices
#10
B Gualeni, S A Coulman, D Shah, P F Eng, H Ashraf, P Vescovo, G J Blayney, L-D Piveteau, O J Guy, J C Birchall
BACKGROUND: Translation of cell therapies to the clinic is accompanied by numerous challenges, including controlled and targeted delivery of the cells to their site of action, without compromising cell viability and functionality. OBJECTIVES: To explore the use of hollow microneedle devices (to date only used for the delivery of drugs and vaccines into the skin and for the extraction of biological fluids) to deliver cells into skin in a minimally-invasive, user-friendly and targeted fashion...
September 2, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28855138/development-of-novel-double-decker-microneedle-patches-for-transcutaneous-vaccine-delivery
#11
Akihiko Ono, Hiroaki Azukizawa, Sayami Ito, Yuki Nakamura, Hideo Asada, Ying-Shu Quan, Fumio Kamiyama, Ichiro Katayama, Sachiko Hirobe, Naoki Okada
Microneedle (MN) patches have great potential as transcutaneous vaccine delivery devices because MNs can effectively deliver vaccine antigen into the skin through the micropores formed in the stratum corneum by low-invasive and painless skin puncturing. This study aims to develop novel double-decker MN patches which have not only high safety and efficacy but also broad applicability to various vaccine antigens. We developed two types of MN patches (PGA-MN and Nylon-MN) that are made from polyglycolic acid and Nylon-6...
August 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28852000/drug-delivery-system-based-on-salmon-dna-nano-and-micro-scale-structures
#12
Yunwoo Lee, Sreekantha Reddy Dugansani, So Hee Jeon, Soon Hyoung Hwang, Jae-Hyun Kim, Sung Ha Park, Jun-Ho Jeong
Microneedles, fabricated by nano-moulding technology show great promise in the field of drug delivery by enabling the painless self-administration of drugs in a patient-friendly manner. In this study, double-stranded salmon DNA (SDNA) was used as both a drug-delivery vehicle and structural material with a microneedle system. SDNA is non-toxic and demonstrates good mechanical robustness, mouldability, biocompatibility, bio-absorbability, and binding affinity with drug molecules for bio-functional applications...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828737/cationic-niosomes-for-enhanced-skin-immunization-of-plasmid-dna-encoding-ovalbumin-via-hollow-microneedles
#13
Boonnada Pamornpathomkul, Nattisa Niyomtham, Boon-Ek Yingyongnarongkul, Chutinun Prasitpuriprecha, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit
The purpose of the present study was to evaluate the use of cationic niosomes composed of Span20:cholesterol:cationic lipid (N (1),N (1)-dimyristeroyloxyethyl-spermine) at the molar ratio of 2.5:2.5:0.5 mM combined with hollow microneedle (MN) devices for in vivo skin immunization of plasmid DNA-encoding ovalbumin (pOVA). The results revealed that using hollow MNs with cationic niosomes for pOVA penetration successfully induced both humoral and cell-mediated immune responses including immunoglobulin G (IgG) antibody responses, interleukin-4 (IL-4), and interferon gamma (IFN-γ) cytokine secretion...
August 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28826880/dissolving-microneedles-integrated-with-liquid-crystals-facilitate-transdermal-delivery-of-sinomenine-hydrochloride
#14
Zhiping Gui, Xingxing Wu, Shuyan Wang, Yingji Cao, Jun Wan, Qianqian Shan, Zhuanzhuan Yang, Jiwen Zhang, Shuangying Gui
The purpose of this study was to investigate the feasibility of delivering sinomenine hydrochloride (SH) transdermally using a composite dissolving microneedles (DM) which integrated with liquid crystals (H2). The fabricated SH-loaded composite DM was evaluated for their appearance, mechanical strength, irritation, efficiency of transdermal delivery of SH. Results depicted that optimized SH-loaded composite DM had sufficient mechanical strength to pierce into rat skin. The in vitro permeability study in rat skin was successfully performed using Franz diffusion cell which showed that the cumulative permeation of SH in the composite DM were significantly increased compared with H2 group (P<0...
August 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28821461/cutaneous-vaccination-with-coated-microneedles-prevents-development-of-airway-allergy
#15
Akhilesh Kumar Shakya, Chang Hyun Lee, Harvinder Singh Gill
Allergy cases are increasing worldwide. Currently allergies are treated after their appearance in patients. However, now there is effort to make a preventive vaccine against allergies. The rationale is to target patient populations that are already sensitized to allergens but have yet to develop severe forms of the allergic disease, or who are susceptible to allergy development but have not yet developed them. Subcutaneous injections and the sublingual route have been used as the primary mode of preventive vaccine delivery...
August 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28817072/efficient-transdermal-delivery-of-alendronate-a-nitrogen-containing-bisphosphonate-using-tip-loaded-self-dissolving-microneedle-arrays-for-the-treatment-of-osteoporosis
#16
Hidemasa Katsumi, Yutaro Tanaka, Kaori Hitomi, Shu Liu, Ying-Shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). We observed micron-scale pores in rat skin just after application of ALN(TIP)-MN, indicating that transdermal pathways for ALN were created by MN. ALN was rapidly released from the tip of MNs as observed in an in vitro release study...
August 17, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28796657/microneedling-a-review-and-practical-guide
#17
Tina S Alster, Paul M Graham
BACKGROUND: Microneedling is a relatively new treatment option in dermatology and has been touted for a broad range of applications including skin rejuvenation, acne scarring, rhytides, surgical scars, dyschromia, melasma, enlarged pores, and transdermal drug delivery. The significant increase in minimally invasive procedures that has been reported over the past several years suggest that microneedling may occupy a specific niche for patients who desire measurable clinical results from treatments with little to no recovery...
August 7, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28782384/skin-microneedling-plus-platelet-rich-plasma-versus-skin-microneedling-alone-in-the-treatment-of-atrophic-post-acne-scars-a-split-face-comparative-study
#18
Mohamed Kotb, Shady Mahmoud Ibrahim
INTRODUCTION: Acne scarring is a permanent disfiguring sequel, which can take varied morphological forms. Many therapeutic measures have been performed to improve acne scarring such as microneedling. Our objective is to evaluate the efficacy and safety of microneedling alone versus microneedling in combined with platelet rich plasma in the treatment of post acne Methods: The study included 35 patients with mild to severe post acne atrophic scar. All the patients received four sequential treatments of skin microneedling alone on the right side of the face and skin microneedling followed by topical application of PRP on the left side of the face with an interval of 3 weeks...
August 7, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28780461/nano-patterning-of-a-stainless-steel-microneedle-surface-to-improve-the-dip-coating-efficiency-of-a-dna-vaccine-and-its-immune-response
#19
Daeyoon Jung, N Sanoj Rejinold, Jeong-Eun Kwak, Su-Hyung Park, Yeu-Chun Kim
DNA vaccination with microneedles (MNs) into the skin represents a potential therapeutic approach for the clinical treatment of viral diseases as well as for intradermal genetic immunization. In this study, we investigated a DNA vaccination against the severe fever with thrombocytopenia syndrome virus (SFTSV) delivered by nano-patterned microneedles (nMNs) to improve the efficiency compared to a conventional MN vaccination. Because DNA vaccinations delivered by coated MNs have major disadvantages such as a poor coating efficiency and immunogenicity, additional excipients are necessary...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28776235/an-array-of-porous-microneedles-for-transdermal-monitoring-of-intercellular-swelling
#20
Kuniaki Nagamine, Jun Kubota, Hiroyuki Kai, Yoshinobu Ono, Matsuhiko Nishizawa
An array of porous microneedles was developed for minimally-invasive transdermal electrolytic connection through the human skin barrier, the stratum corneum. The length of microneedle was designed to be 100 μm so that it penetrates into the epidermis layer without pain. Each microneedle was supported by a thicker cylindrical post protruding from a planar substrate to realize its effective penetration even into elastic human skin. Since this support (post and substrate) was equally porous as the needles, the needle chip was entirely permeable for electrolyte...
September 2017: Biomedical Microdevices
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