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Microneedling skin

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https://www.readbyqxmd.com/read/28530151/microneedles-for-vaccine-delivery-challenges-and-future-perspectives
#1
Chong In Shin, Seong Dong Jeong, N Sanoj Rejinold, Yeu-Chun Kim
Vaccine delivery to the skin using conventional needles is associated with needle-stick injuries and needle-phobia, which are all major obstacles to vaccination. The development of microneedles has enabled to overcome these limitations and as a result viral, DNA and bacterial vaccines have been studied for the delivery into the skin. Research has shown the superiority of microneedle vaccination over conventional needles in terms of immunogenicity, vaccine stability and dose-sparing abilities in animals and humans...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530093/iron-oxide-nanoparticles-powered-micro-optical-coherence-tomography-for-in-situ-imaging-the-penetration-and-swelling-of-polymeric-microneedles-in-skin
#2
Razina Z Seeni, Xiaojun Yu, Hao Chang, Peng Chen, Linbo Liu, Chenjie Xu
In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers for their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When design and characterize such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time non-invasive imaging methodology by integrating iron oxide (Fe3O4) nanoparticles into polymeric MNs to enhance image contrast for micro-optical coherence tomography (µOCT) imaging...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28508376/in-vivo-and-qualitative-studies-investigating-the-translational-potential-of-microneedles-for-use-in-the-older-population
#3
Helen L Quinn, Carmel M Hughes, Ryan F Donnelly
Microneedles (MNs) are a novel transdermal drug delivery platform, rapidly progressing from a substantive evidence base, towards commercialisation. As part of this transition, it is important to consider the future use of MNs by older people in order to ensure optimal therapeutic outcomes for this unique and increasing population group. This paper, therefore, considers the use of MNs by those aged over 65 years, investigating insertion parameters in ageing skin, alongside the feasibility and acceptability of the technology...
May 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28504480/therapeutic-effect-of-microneedling-and-autologous-platelet-rich-plasma-in-the-treatment-of-atrophic-scars-a-randomized-study
#4
Zeinab A Ibrahim, Amal A El-Ashmawy, Ola A Shora
BACKGROUND: New treatments and techniques were being added over the last few years to treat atrophic scars with variable results and adverse effects. AIM OF THE WORK: The aim of this study was to evaluate and compare the therapeutic efficacy and safety of microneedling, autologous platelet-rich plasma, and combination of both procedures in the treatment of atrophic scars. PATIENTS AND METHODS: This study included 90 patients with atrophic scars and were classified randomly into three groups: I: 28 patients treated with microneedling, one session every 4 weeks; II: 34 patients treated with intradermal injection of platelet-rich plasma, one session every 2 weeks; and III: 28 patients treated with alternative sessions of each microneedling and platelet-rich plasma, 2 weeks between each session, for a maximum of six sessions...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28494734/recent-advances-in-skin-penetration-enhancers-for-transdermal-gene-and-drug-delivery
#5
Morteza Amjadi, Babak Mostaghaci, Metin Sitti
There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the skin penetration depth of pharmacological agents. This article reviews recent advances in the development of various strategies for skin penetration enhancement...
May 10, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28489798/efficacy-of-functional-microarray-of-microneedles-combined-with-topical-tranexamic-acid-for-melasma-a-randomized-self-controlled-split-face-study
#6
Yang Xu, Renyan Ma, Juliandri Juliandri, Xiaoyan Wang, Bai Xu, Daguang Wang, Yan Lu, Bingrong Zhou, Dan Luo
To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0.5% TA solution once per week for 12 weeks. The other half-face was the control, treated with a sham device plus topical 0.5% TA solution. At baseline and at weeks 4, 8, and 12 of treatment, clinical (photographic) evaluations and parameters determined by Visia were recorded...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28475834/expanding-transdermal-delivery-with-lipid-nanoparticles-a-new-drug-in-nlc-in-adhesive-design
#7
M Mendes, S C C Nunes, J J Sousa, A A C C Pais, C Vitorino
A monolithic drug-in-NLC-in-adhesive transdermal patch, with a novel design, was developed for codelivery of olanzapine (OL) and simvastatin (SV). Nanostructured lipid carriers (NLC) and enhancers were used as passive strategies, while the pretreatment of the skin with Dermaroller was tested as an active approach. The formulation was optimized for composition in a quality by design basis, in terms of enhancer and adhesive, with focus on permeation behavior, adhesion properties, and cytotoxicity. Propylene glycol promoted the best permeation rate for both drugs, with enhancement ratios of 8...
May 19, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28461268/formulation-and-characterisation-of-dissolving-microneedles-for-the-transdermal-delivery-of-therapeutic-peptides
#8
Colin Dillon, Helen Hughes, Niall J O'Reilly, Peter McLoughlin
The highly effective barrier properties of the stratum corneum (SC) limit the application of transdermal delivery to relatively small, lipophilic molecules. Microneedles (MNs) however, offer a route to effectively deliver a wide range of pharmaceuticals through the skin, bypassing the SC in a non-invasive and pain-free manner. This study presents a dissolving MN system composed of polyvinylpyrrolidone (PVP) and trehalose to encapsulate active pharmaceutical peptides within the MN matrix. Rapid systemic delivery is then achieved once the needles have penetrated the SC and dissolved in the interstitial fluid of the skin...
April 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28447799/enhanced-transdermal-delivery-by-combined-application-of-dissolving-microneedle-patch-on-serum-treated-skin
#9
Suyong Kim, Manita Dangol, Geonwoo Kang, Shayan F Lahiji, Huisuk Yang, Mingyu Jang, Yonghao Ma, Chengguo Li, Sang Gon Lee, Chang Hyun Kim, Young Wook Choi, So Jeong Kim, Ja Hyun Ryu, Ji Hwoon Baek, Jaesuk Koh, Hyungil Jung
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated in a biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the encapsulated drugs into the body. However, because of limited loading capacity of drugs within microsized structures, only a small dosage can be delivered, which is often insufficient for patients. We propose a novel DMN application that combines topical and DMN application simultaneously to improve skin permeation efficiency...
May 5, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28444555/evaluating-the-effectiveness-of-a-novel-atomized-liquid-needle-free-transdermal-delivery-system
#10
Yi-Huei Huang, Chieh-Shen Hu, Yi-Jhen Ke, Chiao-Hsi Chiang, Po-Da Hong, Ming-Kung Yeh
Needle-free jet injections constitute a crucial method for drug delivery. A novel liquid drug delivery system has been proposed recently, in which pressure atomizes liquid before delivering that atomized liquid to the patient's body; however, the mechanism and efficiency of the system are unclear. This study explored the shot delivery pressure, penetration depth, and cumulative amount of permeation of this system. This system was used to deliver 0.5% (w/v) methylene blue to agarose phantoms at various shot delivery pressures...
April 25, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28434892/effective-humoral-immune-response-from-a-h1n1-dna-vaccine-delivered-to-the-skin-by-microneedles-coated-with-plga-based-cationic-nanoparticles
#11
HaeYong Seok, Jin Yong No, Dae Yong Lee, Sung Jin Kim, Chang Seon Song, Yeu Chun Kim
Intradermal DNA vaccination is a promising method of immunization that overcomes some practical drawbacks of conventional intramuscular vaccinations. However, it is difficult to deliver DNA vaccines to target cells in the skin and polyplexes. This study outlines the development of an intradermal pH1N1 DNA vaccine delivery platform using microneedles (MNs) coated with a polyplex containing poly lactic-co-glycolic acid/polyethyleneimine (PLGA/PEI) nanoparticles (NPs). Stainless steel MNs with enhanced hydrophilicity have been manufactured by silanization, which improves coating efficiency...
April 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28432727/efficacy-of-fractionated-microneedle-radiofrequency-with-and-without-adding-subcision-for-the-treatment-of-atrophic-facial-acne-scars-a-randomized-split-face-clinical-study
#12
Gita Faghihi, Nazila Poostiyan, Ali Asilian, Bahareh Abtahi-Naeini, Masoom Shahbazi, Fariba Iraji, Farahnaz Fatemi Naeini, Mohammad Ali Nilforoushzadeh
BACKGROUND: There is no gold standard treatment for facial acne scars, and overall, little literature exists about the combination therapy for treatment of acne scar. AIMS: The aim of this study was to evaluate the efficacy of fractionated microneedle radiofrequency (FMR) vs FMR combined with subcision for the treatment of atrophic acne scars. PATIENTS/METHODS: This was a randomized, split-face clinical study of 25 patients with II-IV Fitzpatrick skin types with moderate to severe facial atrophic acne scars...
April 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28432615/fabrication-physicochemical-characterization-and-performance-evaluation-of-biodegradable-polymeric-microneedle-patch-system-for-enhanced-transcutaneous-flux-of-high-molecular-weight-therapeutics
#13
Viral Shah, Bijaya Krushna Choudhury
A revolutionary paradigm shift is being observed currently, towards the use of therapeutic biologics for disease management. The present research was focused on designing an efficient dosage form for transdermal delivery of α-choriogonadotropin (high molecular weight biologic), through biodegradable polymeric microneedles. Polyvinylpyrrolidone-based biodegradable microneedle arrays loaded with high molecular weight polypeptide, α-choriogonadotropin, were fabricated for its systemic delivery via transdermal route...
April 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28424755/rapid-low-cost-prototyping-of-transdermal-devices-for-personal-healthcare-monitoring
#14
Sanjiv Sharma, Anwer Saeed, Christopher Johnson, Nikolaj Gadegaard, Anthony Eg Cass
The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems associated with current commercially available wearable sensors to be overcome. These particularly include reliability, comfort and cost...
April 2017: Sensing and Bio-Sensing Research
https://www.readbyqxmd.com/read/28418236/novel-approach-of-using-near-infrared-responsive-pegylated-gold-nanorod-coated-poly-l-lactide-microneedles-to-enhance-the-antitumor-efficiency-of-docetaxel-loaded-mpeg-pdlla-micelles-for-treating-an-a431-tumor
#15
Ying Hao, MingLing Dong, TaoYe Zhang, JinRong Peng, YanPeng Jia, YiPing Cao, ZhiYong Qian
The combination of chemotherapy and photothermal therapy (PTT) plays a significant role in synergistic tumor therapy. However, a high dosage of chemotherapy drugs or photothermal agents may cause series side effects. To overcome these challenges, we designed a near-infrared (NIR) responsive PEGylated gold nanorod (GNR-PEG) coated poly(l-lactide) microneedle (PLLA MN) system (GNR-PEG@MN) to enhance antitumor efficiency of docetaxel-loaded MPEG-PDLLA (MPEG-PDLLA-DTX) micelles for treating an A431 tumor. The as-made GNR-PEG@MNs contained only 31...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28403263/microneedling-in-all-skin-types-a-review
#16
Lauren Meshkov Bonati, Gorana Kuka Epstein, Tamara Lazic Strugar
<p>INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.</p> <p>METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Search terms included: "microneedling," "percutaneous collagen induction," "needling," "skin needling," and "dermaroller...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28390901/bcg-vaccine-powder-laden-and-dissolvable-microneedle-arrays-for-lesion-free-vaccination
#17
Fan Chen, Qinying Yan, Yang Yu, Mei X Wu
Live attenuated Bacille Calmette-Guerin (BCG) bacillus is the only licensed vaccine for tuberculosis prevention worldwide to date. It must be delivered intradermally to be effective, which causes severe skin inflammation and sometimes, permanent scars. To minimize the side effects, we developed a novel microneedle array (MNA) that could deliver live attenuated freeze-dried BCG powder into the epidermis in a painless, lesion-free, and self-applicable fashion. The MNA was fabricated with biocompatible and dissolvable hyaluronic acid with a deep cave formed in the basal portion of each microneedle, into which BCG powder could be packaged directly...
April 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28385631/statistically-optimized-fast-dissolving-microneedle-transdermal-patch-of-meloxicam-a-patient-friendly-approach-to-manage-arthritis
#18
Sejal Amodwala, Praveen Kumar, Hetal P Thakkar
INTRODUCTION: The long term administration of Meloxicam for the management of arthritis, a chronic disorder, results in gastrointestinal disturbances leading to poor patient compliance. Considering the favorable molecular weight, therapeutic dose, biological half-life and log P value of meloxicam for transdermal delivery, its fast dissolving microneedle patch, with an ability to breach the stratum corneum and efficiently deliver the cargo to deeper skin layers, were developed. METHODS: Microneedle patch of low molecular weight polyvinyl alcohol and polyvinylpyrrolidone was prepared using Polydimethylsiloxane micromolds...
April 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28381808/dissolving-microneedles-as-skin-allergy-test-device
#19
Yukako Ito, Kengo Matsumoto, Noriyuki Osakama, Ryosuke Yoshioka, Shinji Kobuchi, Toshiyuki Sakaeda, Kanji Takada
The possibility of using dissolving microneedles (DMs) as a skin allergy test device was studied in rats. Poly-L-arginine was used as a model allergen. Dextran was used to prepare three kinds of DM array chips containing different doses of poly-L-arginine: 17.1±0.5 µg (low-dose DM), 42.2±0.8 µg (medium-dose DM), and 87.4±1.1 µg (high-dose DM); each 1.0 cm(2) chip contained 300 DMs. The mean lengths of the low-, medium-, and high-dose DM were 489±3, 485±3, and 492±1 µm and mean diameters of the base were 301±2, 299±1, and 299±2 µm, respectively...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28375775/engineering-microneedle-patches-for-vaccination-and-drug-delivery-to-skin
#20
Mark R Prausnitz
Microneedle patches (MNPs) contain arrays of solid needles measuring hundreds of microns in length that deliver drugs and vaccines into skin in a painless, easy-to-use manner. Optimal MNP design balances multiple interdependent parameters that determine mechanical strength, skininsertion reliability, drug delivery efficiency, painlessness, manufacturability, and other features of MNPs that affect their performance. MNPs can be made by adapting various microfabrication technologies for delivery of small-molecule drugs, biologics, and vaccines targeted to the skin, which can have pharmacokinetic and immunologic advantages...
March 24, 2017: Annual Review of Chemical and Biomolecular Engineering
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