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https://www.readbyqxmd.com/read/29775714/novel-bletilla-striata-polysaccharide-microneedles-fabrication-characterization-and-in-vitro-transcutaneous-drug-delivery
#1
Lingli Hu, Zhencheng Liao, Qiqi Hu, Katherine G Maffucci, Yan Qu
Dissolving microneedles (MNs) have been widely studied for their applications in effective transdermal drug delivery due to their ability to dissolve within the skin. This study details the first reported successful preparation of novel dissolving MNs using Bletilla striata polysaccharide (BSP), a natural glucomannan material, and investigates the potential for using such MNs as a transdermal drug delivery vector. The prepared dissolving Bletilla striata polysaccharide microneedles (BMNs) had excellent moldability and were easily detached from the mold...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29765638/porous-polymer-coatings-on-metal-microneedles-for-enhanced-drug-delivery
#2
Asad Ullah, Chul Min Kim, Gyu Man Kim
We present a simple method to coat microneedles (MNs) uniformly with a porous polymer (PLGA) that can deliver drugs at high rates. Stainless steel (SS) MNs of high mechanical strength were coated with a thin porous polymer layer to enhance their delivery rates. Additionally, to improve the interfacial adhesion between the polymer and MNs, the MN surface was modified by plasma treatment followed by dip coating with polyethyleneimine, a polymer with repeating amine units. The average failure load (the minimum force sufficient for detaching the polymer layer from the surface of SS) recorded for the modified surface coating was 25 N, whereas it was 2...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29722966/sodium-hyaluronate-chitosan-composite-microneedles-as-a-single-dose-intradermal-immunization-system
#3
Yu-Hsiu Chiu, Mei-Chin Chen, Shu-Wen Wan
Enhancing the immune response to vaccines and minimizing the need for repeated inoculations remain a challenge in clinical vaccination. This study developed a composite microneedle (MN), composed of a sodium hyaluronate (HA) tip and a chitosan base, for biphasic antigen release and evaluated the potential of using this MN formulation as an intradermal delivery system for single-dose vaccination. Upon skin insertion, the dissolvable HA tip dissolved within the skin for rapid release of the encapsulated antigens, thus priming the immune system, while the biodegradable chitosan base remained in the dermis for prolonged antigen release for 4 weeks, thus further boosting the stimulated immunity...
May 3, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29722421/carbon-nanotubes-cnts-based-advanced-dermal-therapeutics-current-trends-and-future-potential
#4
REVIEW
Kaushik Kuche, Rahul Maheshwari, Vishakha Tambe, Kit-Kay Mak, Hardi Jogi, Nidhi Raval, Mallikarjuna Rao Pichika, Rakesh Kumar Tekade
The search for effective and non-invasive delivery modules to transport therapeutic molecules across skin has led to the discovery of a number of nanocarriers (viz.: liposomes, ethosomes, dendrimers, etc.) in the last few decades. However, available literature suggests that these delivery modules face several issues including poor stability, low encapsulation efficiency, and scale-up hurdles. Recently, carbon nanotubes (CNTs) emerged as a versatile tool to deliver therapeutics across skin. Superior stability, high loading capacity, well-developed synthesis protocol as well as ease of scale-up are some of the reason for growing interest in CNTs...
May 3, 2018: Nanoscale
https://www.readbyqxmd.com/read/29722090/controlled-delivery-of-insulin-using-rapidly-separating-microneedles-fabricated-from-genipin-crosslinked-gelatin
#5
Bo Zhi Chen, Mohammad Ashfaq, Dan Dan Zhu, Xiao Peng Zhang, Xin Dong Guo
Rapidly separating genepin-crosslinked gelatin (RS-GC) microneedles (MNs) mounted on the polyvinyl alcohol (PVA)-coated polylactic acid (PLA) MNs (RS-PGC-MNs) are fabricated, in which GC-MNs deliver insulin within the skin and the PLA supporting array is easily separated by the dissolution of the PVA layer. The release of insulin is controlled by utilizing the virtue of genipin as a crosslinking agent for producing biocompatible GC-MNs. The degree of crosslinking enhances the mechanical strength as well as humidity resistance...
May 2, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29721085/efficient-delivery-of-nucleic-acid-molecules-into-skin-by-combined-use-of-microneedle-roller-and-flexible-interdigitated-electroporation-array
#6
Dong Huang, Deyao Zhao, Xiaoxia Wang, Chunhui Li, Tongren Yang, Lili Du, Zewen Wei, Qiang Cheng, Huiqing Cao, Zicai Liang, Yuanyu Huang, Zhihong Li
Rationale: Delivery of nucleic acid molecules into skin remains a main obstacle for various types of gene therapy or vaccine applications. Here we propose a novel electroporation approach via combined use of a microneedle roller and a flexible interdigitated electroporation array (FIEA) for efficient delivery of DNA and siRNA into mouse skin. Methods: Using micromachining technology, closely spaced gold electrodes were made on a pliable parylene substrate to form a patch-like electroporation array, which enabled close surface contact between the skin and electrodes...
2018: Theranostics
https://www.readbyqxmd.com/read/29708770/drug-delivery-using-microneedle-patches-not-just-for-skin
#7
Jeong Woo Lee, Mark R Prausnitz
No abstract text is available yet for this article.
April 30, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29707828/enhanced-immunity-in-intradermal-vaccination-by-novel-hollow-microneedles
#8
N Ogai, I Nonaka, Y Toda, T Ono, S Minegishi, A Inou, M Hachiya, H Fukamizu
BACKGROUND: The intradermal (ID) route for vaccination represents an effective alternative to subcutaneous (SC)/intramuscular administration to induce protective immunity. However, a critical issue associated with ID vaccination is the precise delivery of solution in the upper dermis, which ensures enhanced immunity. METHODS: We fabricated a hollow microneedle unit made of poly-glycolic acid by injection molding and bonding, and created a dedicated prototype injector...
April 29, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29687566/intralesional-bleomycin-injection-vs-microneedling-assisted-topical-bleomycin-spraying-in-treatment-of-plantar-warts
#9
Mohamed R Al-Naggar, Ahmad S Al-Adl, Ali R Rabie, Mahmoud R Abdelkhalk, Mohamed L Elsaie
BACKGROUND: Warts, or verrucae, are benign epithelial profilerations of skin and mucosa caused by infection with HPV and poses a challenge to treat. OBJECTIVE: To compare between single and microneedling-assisted multipuncture techniques of intralesional application in treatment of plantar warts. METHODS: The study included 60 Patients who were divided into two groups (A&B). Each group consisted of (30) patients. Group (A) subjects received intralesional bleomycin with a single injection using syringe needle...
April 23, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29666252/mechanisms-of-sampling-interstitial-fluid-from-skin-using-a-microneedle-patch
#10
Pradnya P Samant, Mark R Prausnitz
Although interstitial fluid (ISF) contains biomarkers of physiological significance and medical interest, sampling of ISF for clinical applications has made limited impact due to a lack of simple, clinically useful techniques that collect more than nanoliter volumes of ISF. This study describes experimental and theoretical analysis of ISF transport from skin using microneedle (MN) patches and demonstrates collection of >1 µL of ISF within 20 min in pig cadaver skin and living human subjects using an optimized system...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29663698/comparative-study-of-two-droplet-based-dissolving-microneedle-fabrication-methods-for-skin-vaccination
#11
Chisong Lee, Hongil Kim, Suyong Kim, Shayan F Lahiji, Na-Young Ha, Huisuk Yang, Geonwoo Kang, Hai Yen Thi Nguyen, Yuri Kim, Myung-Sik Choi, Nam-Hyuk Cho, Hyungil Jung
Dissolving microneedles (DMNs) have been widely studied in medical applications due to their pain-free administration, superior efficiency, and safe drug delivery. In skin vaccination, preserving the activity of the encapsulated antigen is an important consideration, as antigen activity is lost during DMN fabrication because of various stress factors. These stress factors vary between fabrication methods and each method affects the antigen's activity to different degrees. In this study, the activity of encapsulated antigens delivered by DMNs is compared between two recently developed DMN fabrication methods; droplet-born air blowing (DAB) and centrifugal lithography (CL) for a model scrub typhus vaccine antigen, ScaA...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29663691/an-evaluation-of-the-antiaging-properties-of-strawberry-hydrolysate-treatment-enriched-with-l-ascorbic-acid-applied-with-microneedle-mesotherapy
#12
Agata Markiewicz, Malwina Zasada, Anna Erkiert-Polguj, Marzena Wieckowska-Szakiel, Elzbieta Budzisz
BACKGROUND: Mature skin is characterized by a loss of elasticity, hyperpigmentation, and dehydration. L-ascorbic acid stimulates the synthesis of collagen type I, inhibits melanogenesis, and helps to maintain correct skin hydration. Combining microneedle mesotherapy with the application of preparations rich in vitamin C results in better therapeutic effects due to the improved absorption of active substances. The study evaluates the effectiveness of the application of strawberry hydrolysate enriched with L-ascorbic acid using microneedle mesotherapy...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29652837/fabrication-of-composite-microneedle-array-electrode-for-temperature-and-bio-signal-monitoring
#13
Yiwei Sun, Lei Ren, Lelun Jiang, Yong Tang, Bin Liu
Body temperature and bio-signals are important health indicators that reflect the human health condition. However, monitoring these indexes is inconvenient and time-consuming, requires various instruments, and needs professional skill. In this study, a composite microneedle array electrode (CMAE) was designed and fabricated. It simultaneously detects body temperature and bio-signals. The CMAE consists of a 6 × 6 microneedles array with a height of 500 μm and a base diameter of 200 μm. Multiple insertion experiments indicate that the CMAE possesses excellent mechanical properties...
April 13, 2018: Sensors
https://www.readbyqxmd.com/read/29652835/fabrication-of-flexible-microneedle-array-electrodes-for-wearable-bio-signal-recording
#14
Lei Ren, Shujia Xu, Jie Gao, Zi Lin, Zhipeng Chen, Bin Liu, Liang Liang, Lelun Jiang
Laser-direct writing (LDW) and magneto-rheological drawing lithography (MRDL) have been proposed for the fabrication of a flexible microneedle array electrode (MAE) for wearable bio-signal monitoring. Conductive patterns were directly written onto the flexible polyethylene terephthalate (PET) substrate by LDW. The microneedle array was rapidly drawn and formed from the droplets of curable magnetorheological fluid with the assistance of an external magnetic field by MRDL. A flexible MAE can maintain a stable contact interface with curved human skin due to the flexibility of the PET substrate...
April 13, 2018: Sensors
https://www.readbyqxmd.com/read/29621751/skin-barrier-restoration-and-moisturization-using-horse-oil-loaded-dissolving-microneedle-patches
#15
Chisong Lee, Younghyon Andrew Eom, Huisuk Yang, Mingyu Jang, Sang Uk Jung, Ye Oak Park, Si Eun Lee, Hyungil Jung
BACKGROUND: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. METHODS: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies...
April 5, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29616489/zein-microneedles-for-localized-delivery-of-chemotherapeutic-agents-to-treat-breast-cancer-drug-loading-release-behavior-and-skin-permeation-studies
#16
Shubhmita Bhatnagar, Pooja Kumari, Srijanaki Paravastu Pattarabhiran, Venkata Vamsi Krishna Venuganti
Localized delivery of chemotherapeutic agents to treat breast cancer could limit their adverse drug reactions. The aim of this study was to investigate the influence of physico-chemical properties of chemotherapeutic agents in their loading, release behavior, and skin permeation using microneedles. Zein microneedles were fabricated using the micromolding technique containing 36 microneedles in a 1-cm2 area. These microneedles were loaded with two anti-breast cancer drugs, tamoxifen and gemcitabine, having different water solubilities...
April 3, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29604374/insulin-delivery-systems-combined-with-microneedle-technology
#17
Xuan Jin, Dan Dan Zhu, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo
Diabetes, a metabolic disorder of glucose, is a serious chronic disease and an important public health problem. Insulin is one of the hormones for modulating blood glucose level and the products of which is indispensable for most diabetes patients. Introducing microneedles (MNs) to insulin delivery is promising to pave the way for modulating glucose level noninvasively of diabetes patients, as which born to be painless, easy to handle and no need of any power supply. In this work, we review the process of insulin delivery systems (IDSs) based on MN technology in terms of two categories: drug free MNs and drug loaded MNs...
March 28, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29601621/prospective-randomized-investigator-blinded-split-face-evaluation-of-a-topical-crosslinked-hyaluronic-acid-serum-for-post-procedural-improvement-of-skin-quality-and-biomechanical-attributes
#18
Hema Sundaram, Angnieszka Cegielska, Agnieszka Wojciechowska, Patrice Delobel
BACKGROUND: This split-face, controlled study investigated the ability of a topical crosslinked hyaluronic acid formulation (RHA serum) to enhance clinical results from fillers, microneedling, or chemical peeling of aging skin. Previous comparative skin explant studies demonstrated greater efficacy of RHA serum than topical non-crosslinked high or low molecular weight hyaluronic acid in decreasing trans-epidermal water loss, increasing epidermal hydration, and improving corneocyte microstructure...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29595852/composite-dissolving-microneedle-patches-for-chemotherapy-and-photothermal-therapy-in-superficial-tumor-treatment
#19
Peng Pei, Fan Yang, Jiaxing Liu, Haoran Hu, Xiaoyu Du, Nobutaka Hanagata, Shichang Zhao, Yufang Zhu
A combination of chemotherapy and photothermal therapy (PTT) has emerged as a promising strategy for cancer therapy. To ensure that the chemotherapeutic drug and photothermal agent can be simultaneously delivered to the tumor site to exert their synergistic effects, a safe and efficient delivery system is needed. Herein, we fabricated doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) using a two-step casting process. Mesoporous silica nanoparticles (MSNs) were used to improve the ICG stability and avoid reducing its PTT efficiency in vivo...
March 29, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29574973/adenosine-loaded-dissolving-microneedle-patches-to-improve-skin-wrinkles-dermal-density-elasticity-and-hydration
#20
G Kang, T N T Tu, S Kim, H Yang, M Jang, D Jo, J Rye, J Baek, H Jung
OBJECTIVE: Although dissolving microneedle patches have been widely studied in the cosmetics field, no comparisons have been drawn with the topical applications available for routine use. In this study, two wrinkle-improving products, adenosine-loaded dissolving microneedle patches and an adenosine cream, were evaluated for efficacy, with respect to skin wrinkling, dermal density, elasticity, and hydration, and safety in a clinical test on the crow's feet area. METHODS: Clinical efficacy and safety tests were performed for 10 weeks on 22 female subjects with wrinkles around their eyes...
March 25, 2018: International Journal of Cosmetic Science
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