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Microneedling skin

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https://www.readbyqxmd.com/read/28642154/a-boosting-skin-vaccination-with-dissolving-microneedle-patch-encapsulating-m2e-vaccine-broadens-the-protective-efficacy-of-conventional-influenza-vaccines
#1
Wandi Zhu, Winston Pewin, Chao Wang, Yuan Luo, Gilbert X Gonzalez, Teena Mohan, Mark R Prausnitz, Bao-Zhong Wang
The biodegradable microneedle patch (MNP) is a novel technology for vaccine delivery that could improve the immunogenicity of vaccines. To broaden the protective efficiency of conventional influenza vaccines, a new 4M2e-tFliC fusion protein construct containing M2e sequences from different subtypes was generated. Purified fusion protein was encapsulated into MNPs with a biocompatible polymer for use as a boosting vaccine. The results demonstrated that mice receiving a conventional inactivated vaccine followed by a skin-applied dissolving 4M2e-tFliC MNP boost could better maintain the humoral antibody response than that by the conventional vaccine-prime alone...
June 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28633107/effects-of-chemical-and-physical-enhancement-techniques-on-transdermal-delivery-of-3-fluoroamphetamine-hydrochloride
#2
Ashana Puri, Kevin S Murnane, Bruce E Blough, Ajay K Banga
The present study investigated the passive transdermal delivery of 3-fluoroamphetamine hydrochloride (PAL-353) and evaluated the effects of chemical and physical enhancement techniques on its permeation through human skin. In vitro drug permeation studies through dermatomed human skin were performed using Franz diffusion cells. Passive permeation of PAL-353 from propylene glycol and phosphate buffered saline as vehicles was studied. Effect of oleic acid, maltose microneedles, ablative laser, and anodal iontophoresis on its transdermal permeation was investigated...
June 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28618841/assessment-of-solid-microneedle-rollers-to-enhance-transmembrane-delivery-of-doxycycline-and-inhibition-of-mmp-activity
#3
Abbie Omolu, Maryse Bailly, Richard M Day
Many chronic wounds exhibit high matrix metalloproteinase (MMP) activity that impedes the normal wound healing process. Intradermal delivery (IDD) of sub-antimicrobial concentrations of doxycycline, as an MMP inhibitor, could target early stages of chronic wound development and inhibit further wound progression. To deliver doxycycline intradermally, the skin barrier must be disrupted. Microneedle rollers offer a minimally invasive technique to penetrate the skin by creating multiple microchannels that act as temporary conduits for drugs to diffuse through...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28574158/efficacy-and-safety-of-a-new-microneedle-patch-for-skin-brightening-a-randomized-split-face-single-blind-study
#4
Kui Young Park, Hyun Jung Kwon, Changjin Lee, Daegun Kim, Jun Jin Yoon, Myeong Nam Kim, Beom Joon Kim
BACKGROUND: Although microneedles are one of the best transdermal drug delivery systems for active compounds, few clinical trials have examined the safety and efficacy of brightening microneedle patches. AIMS: To determine the efficacy and safety of a newly developed whitening microneedle patch. PATIENTS/METHODS: A split-face study was designed for efficacy assessment with 34 Korean women applying the tested product (a whitening microneedle patch) on one cheek and a control whitening essence on the other...
June 2, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28552053/microneedle-patches-as-drugs-and-vaccine-delivery-platform
#5
Junwei Li, Mingtao Zeng, Hu Shan, Chunyi Tong
BACKGROUND: Transcutaneous delivery is the ideal method for delivering therapeutic reagents or vaccines into skin. With their promise of self-administration, cost-effective and high efficiency, microneedle patches have been studied intensively as therapeutic and vaccination delivery platform that replaces injection by syringe. This review aims to summarize the recent advancements of microneedle patches in application for drugs and vaccine delivery. METHODS: We review the most of recently published papers on microneedle patches, summarized their evolution, classification, state- of the-art capabilities and discuss promising application in drugs and vaccine delivery...
May 26, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28549948/microneedles-in-the-clinic
#6
REVIEW
Shubhmita Bhatnagar, Kaushalkumar Dave, Venkata Vamsi Krishna Venuganti
In general, there is a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical and biological properties, and their performance. Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous interest among researchers. Research efforts and publications investigating the design, development and applications of microneedles have exponentially increased in the recent years. Especially, microneedles have been widely studied and developed for cosmetic and therapeutic applications...
May 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28544329/dissolving-microneedle-arrays-for-transdermal-delivery-of-amphiphilic-vaccines
#7
Myunggi An, Haipeng Liu
Amphiphilic vaccine based on lipid-polymer conjugates is a new type of vaccine capable of self-delivering to the immune system. When injected subcutaneously, amphiphilic vaccines efficiently target antigen presenting cells in the lymph nodes (LNs) via a unique albumin-mediated transport and uptake mechanism and induce potent humoral and cellular immune responses. However, whether this new type of vaccine can be administrated via a safe, convenient microneedle-based transdermal approach remains unstudied. For such skin barrier-disruption systems, a simple application of microneedle arrays (MNs) is desired to disrupt the stratum corneum, and for rapid and pain-free self-administration of vaccines into the skin, the anatomic place permeates with an intricate mesh of lymphatic vessels draining to LNs...
May 19, 2017: Small
https://www.readbyqxmd.com/read/28536970/mesoporous-silica-nanoparticle-coated-microneedle-arrays-for-intradermal-antigen-delivery
#8
Jing Tu, Guangsheng Du, M Reza Nejadnik, Juha Mönkäre, Koen van der Maaden, Paul H H Bomans, Nico A J M Sommerdijk, Bram Slütter, Wim Jiskoot, Joke A Bouwstra, Alexander Kros
PURPOSE: To develop a new intradermal antigen delivery system by coating microneedle arrays with lipid bilayer-coated, antigen-loaded mesoporous silica nanoparticles (LB-MSN-OVA). METHODS: Synthesis of MSNs with 10-nm pores was performed and the nanoparticles were loaded with the model antigen ovalbumin (OVA), and coated with a lipid bilayer (LB-MSN-OVA). The uptake of LB-MSN-OVA by bone marrow-derived dendritic cells (BDMCs) was studied by flow cytometry. The designed LB-MSN-OVA were coated onto pH-sensitive pyridine-modified microneedle arrays and the delivery of LB-MSN-OVA into ex vivo human skin was studied...
May 23, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28530151/microneedles-for-vaccine-delivery-challenges-and-future-perspectives
#9
Chong In Shin, Seong Dong Jeong, N Sanoj Rejinold, Yeu-Chun Kim
Vaccine delivery to the skin using conventional needles is associated with needle-stick injuries and needle-phobia, which are all major obstacles to vaccination. The development of microneedles has enabled to overcome these limitations and as a result viral, DNA and bacterial vaccines have been studied for the delivery into the skin. Research has shown the superiority of microneedle vaccination over conventional needles in terms of immunogenicity, vaccine stability and dose-sparing abilities in animals and humans...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530093/iron-oxide-nanoparticle-powered-micro-optical-coherence-tomography-for-in-situ-imaging-the-penetration-and-swelling-of-polymeric-microneedles-in-the-skin
#10
Razina Z Seeni, Xiaojun Yu, Hao Chang, Peng Chen, Linbo Liu, Chenjie Xu
In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers because of their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When designing and characterizing such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time noninvasive imaging methodology by integrating iron oxide (Fe3O4) nanoparticles into polymeric MNs to enhance image contrast for micro-optical coherence tomography (μOCT) imaging...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28508376/in-vivo-and-qualitative-studies-investigating-the-translational-potential-of-microneedles-for-use-in-the-older-population
#11
Helen L Quinn, Carmel M Hughes, Ryan F Donnelly
Microneedles (MNs) are a novel transdermal drug delivery platform, rapidly progressing from a substantive evidence base, towards commercialisation. As part of this transition, it is important to consider the future use of MNs by older people in order to ensure optimal therapeutic outcomes for this unique and increasing population group. This paper, therefore, considers the use of MNs by those aged over 65 years, investigating insertion parameters in ageing skin, alongside the feasibility and acceptability of the technology...
May 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28504480/therapeutic-effect-of-microneedling-and-autologous-platelet-rich-plasma-in-the-treatment-of-atrophic-scars-a-randomized-study
#12
Zeinab A Ibrahim, Amal A El-Ashmawy, Ola A Shora
BACKGROUND: New treatments and techniques were being added over the last few years to treat atrophic scars with variable results and adverse effects. AIM OF THE WORK: The aim of this study was to evaluate and compare the therapeutic efficacy and safety of microneedling, autologous platelet-rich plasma, and combination of both procedures in the treatment of atrophic scars. PATIENTS AND METHODS: This study included 90 patients with atrophic scars and were classified randomly into three groups: I: 28 patients treated with microneedling, one session every 4 weeks; II: 34 patients treated with intradermal injection of platelet-rich plasma, one session every 2 weeks; and III: 28 patients treated with alternative sessions of each microneedling and platelet-rich plasma, 2 weeks between each session, for a maximum of six sessions...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28494734/recent-advances-in-skin-penetration-enhancers-for-transdermal-gene-and-drug-delivery
#13
Morteza Amjadi, Babak Mostaghaci, Metin Sitti
There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the skin penetration depth of pharmacological agents. This article reviews recent advances in the development of various strategies for skin penetration enhancement...
May 10, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28489798/efficacy-of-functional-microarray-of-microneedles-combined-with-topical-tranexamic-acid-for-melasma-a-randomized-self-controlled-split-face-study
#14
RANDOMIZED CONTROLLED TRIAL
Yang Xu, Renyan Ma, Juliandri Juliandri, Xiaoyan Wang, Bai Xu, Daguang Wang, Yan Lu, Bingrong Zhou, Dan Luo
To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0.5% TA solution once per week for 12 weeks. The other half-face was the control, treated with a sham device plus topical 0.5% TA solution. At baseline and at weeks 4, 8, and 12 of treatment, clinical (photographic) evaluations and parameters determined by Visia were recorded...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28475834/expanding-transdermal-delivery-with-lipid-nanoparticles-a-new-drug-in-nlc-in-adhesive-design
#15
M Mendes, S C C Nunes, J J Sousa, A A C C Pais, C Vitorino
A monolithic drug-in-NLC-in-adhesive transdermal patch, with a novel design, was developed for codelivery of olanzapine (OL) and simvastatin (SV). Nanostructured lipid carriers (NLC) and enhancers were used as passive strategies, while the pretreatment of the skin with Dermaroller was tested as an active approach. The formulation was optimized for composition in a quality by design basis, in terms of enhancer and adhesive, with focus on permeation behavior, adhesion properties, and cytotoxicity. Propylene glycol promoted the best permeation rate for both drugs, with enhancement ratios of 8...
May 19, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28461268/formulation-and-characterisation-of-dissolving-microneedles-for-the-transdermal-delivery-of-therapeutic-peptides
#16
Colin Dillon, Helen Hughes, Niall J O'Reilly, Peter McLoughlin
The highly effective barrier properties of the stratum corneum (SC) limit the application of transdermal delivery to relatively small, lipophilic molecules. Microneedles (MNs) however, offer a route to effectively deliver a wide range of pharmaceuticals through the skin, bypassing the SC in a non-invasive and pain-free manner. This study presents a dissolving MN system composed of polyvinylpyrrolidone (PVP) and trehalose to encapsulate active pharmaceutical peptides within the MN matrix. Rapid systemic delivery is then achieved once the needles have penetrated the SC and dissolved in the interstitial fluid of the skin...
April 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28447799/enhanced-transdermal-delivery-by-combined-application-of-dissolving-microneedle-patch-on-serum-treated-skin
#17
Suyong Kim, Manita Dangol, Geonwoo Kang, Shayan F Lahiji, Huisuk Yang, Mingyu Jang, Yonghao Ma, Chengguo Li, Sang Gon Lee, Chang Hyun Kim, Young Wook Choi, So Jeong Kim, Ja Hyun Ryu, Ji Hwoon Baek, Jaesuk Koh, Hyungil Jung
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated in a biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the encapsulated drugs into the body. However, because of limited loading capacity of drugs within microsized structures, only a small dosage can be delivered, which is often insufficient for patients. We propose a novel DMN application that combines topical and DMN application simultaneously to improve skin permeation efficiency...
May 5, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28444555/evaluating-the-effectiveness-of-a-novel-atomized-liquid-needle-free-transdermal-delivery-system
#18
Yi-Huei Huang, Chieh-Shen Hu, Yi-Jhen Ke, Chiao-Hsi Chiang, Po-Da Hong, Ming-Kung Yeh
Needle-free jet injections constitute a crucial method for drug delivery. A novel liquid drug delivery system has been proposed recently, in which pressure atomizes liquid before delivering that atomized liquid to the patient's body; however, the mechanism and efficiency of the system are unclear. This study explored the shot delivery pressure, penetration depth, and cumulative amount of permeation of this system. This system was used to deliver 0.5% (w/v) methylene blue to agarose phantoms at various shot delivery pressures...
April 25, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28434892/effective-humoral-immune-response-from-a-h1n1-dna-vaccine-delivered-to-the-skin-by-microneedles-coated-with-plga-based-cationic-nanoparticles
#19
HaeYong Seok, Jin Yong No, Dae Yong Lee, Sung Jin Kim, Chang Seon Song, Yeu Chun Kim
Intradermal DNA vaccination is a promising method of immunization that overcomes some practical drawbacks of conventional intramuscular vaccinations. However, it is difficult to deliver DNA vaccines to target cells in the skin and polyplexes. This study outlines the development of an intradermal pH1N1 DNA vaccine delivery platform using microneedles (MNs) coated with a polyplex containing poly lactic-co-glycolic acid/polyethyleneimine (PLGA/PEI) nanoparticles (NPs). Stainless steel MNs with enhanced hydrophilicity have been manufactured by silanization, which improves coating efficiency...
April 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28432727/efficacy-of-fractionated-microneedle-radiofrequency-with-and-without-adding-subcision-for-the-treatment-of-atrophic-facial-acne-scars-a-randomized-split-face-clinical-study
#20
Gita Faghihi, Nazila Poostiyan, Ali Asilian, Bahareh Abtahi-Naeini, Masoom Shahbazi, Fariba Iraji, Farahnaz Fatemi Naeini, Mohammad Ali Nilforoushzadeh
BACKGROUND: There is no gold standard treatment for facial acne scars, and overall, little literature exists about the combination therapy for treatment of acne scar. AIMS: The aim of this study was to evaluate the efficacy of fractionated microneedle radiofrequency (FMR) vs FMR combined with subcision for the treatment of atrophic acne scars. PATIENTS/METHODS: This was a randomized, split-face clinical study of 25 patients with II-IV Fitzpatrick skin types with moderate to severe facial atrophic acne scars...
April 22, 2017: Journal of Cosmetic Dermatology
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