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https://www.readbyqxmd.com/read/28327806/invasive-fungal-infection-in-patients-with-hematologic-disorders-in-a-brazilian-tertiary-care-hospital
#1
Milton Camplesi, Hildene Meneses Silva, Adriano Moraes Arantes, Carolina Rodrigues Costa, Fábio Silvestre Ataides, Thaisa Cristina Silva, Maysa de Paula Costa Dos Reis, Maria do Rosário Rodrigues Silva
INTRODUCTION: Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems at a tertiary hospital in Goiânia-GO, Brazil. METHODS: Data from 117 patients, involving 19 cases of IFIs, were collected. The collected data included diagnosis methods, demographics, clinical characteristics, and in vitro susceptibility to different antifungal agents...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28317569/oral-fungal-infections-diagnosis-and-management
#2
REVIEW
David R Telles, Niraj Karki, Michael W Marshall
Oral and maxillofacial fungal infections can appear in high-risk patients, including those immunocompromised. This article explores common oral manifestations of fungal infections in the oral cavity as primary lesions or as a result of disseminated disease. By far the most common oral fungal infection experienced in dentistry is oral candidiasis, which is reviewed in depth from simple oral infections to invasive candidiasis. The review aids the dental practitioner in understanding the full scope of Candida infections and other fungal infections...
April 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28317305/invasive-pulmonary-aspergillosis-due-to-azole-resistant-aspergillus-lentulus
#3
Nobuyuki Tetsuka, Takashi Yaguchi, Hiroyuki Machida, Shuichi Ito, Isao Miyairi
No abstract text is available yet for this article.
March 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28303848/triazole-resistance-in-aspergillus-fumigatus-clinical-isolates-obtained-in-nanjing-china
#4
Ming Zhang, Chun-Lai Feng, Fei Chen, Qian He, Xin Su, Yi Shi
BACKGROUND: During the past decades, the incidence of invasive aspergillosis (IA) caused by Aspergillus fumigatus has increased dramatically. The aims of this study were to investigate the susceptibility of clinical isolates of A. fumigatus to triazole and the underlying cyp51A mutations in triazole-resistant A. fumigatus. METHODS: A total of 126 A. fumigatus clinical isolates from 126 patients with proven or probable IA were obtained from four large tertiary hospitals in Nanjing, China, between August 2012 and July 2015...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28299183/challenges-in-microbiological-diagnosis-of-invasive-aspergillus-infections
#5
REVIEW
Alexandre Alanio, Stéphane Bretagne
Invasive aspergillosis (IA) has been increasingly reported in populations other than the historical hematology patients and there are new questions about the performance of microbiological tools. Microscopy and culture have been completed by biomarkers, either antigens or DNA, and in blood or respiratory specimens or both. First studied in hematology, the antigen galactomannan performance in serum is low in other patient populations where the pathophysiology of the infection can be different and the prevalence of IA is much lower...
2017: F1000Research
https://www.readbyqxmd.com/read/28293759/serious-fungal-diseases-in-the-republic-of-uzbekistan
#6
S A Tilavberdiev, D W Denning, N N Klimko
We have undertaken the first and preliminary estimation of severe and chronic mycotic diseases in the Republic of Uzbekistan, using a model proposed by LIFE (Leading International Fungal Education). Calculation was carried out based on data from 2014. Published results describing mycoses in Uzbekistan were identified. In the absence of published or official data, information about the frequency of mycoses from scientific literature elsewhere in groups at risk of development of fungal infections were taken into account...
March 14, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28292284/is-bulpa-criteria-suitable-for-the-diagnosis-of-probable-invasive-pulmonary-aspergillosis-in-critically-ill-patients-with-chronic-obstructive-pulmonary-disease-a-comparative-study-with-eortc-msg-and-icu-criteria
#7
Linna Huang, Hangyong He, Jingjing Jin, Qingyuan Zhan
BACKGROUND: Three diagnostic criteria have been proposed used for invasive pulmonary aspergillosis (IPA) diagnosis, namely EORTC/ MSG criteria, Bulpa criteria and intensive care unit (ICU) criteria. The Bulpa criteria were proposed to diagnose IPA in chronic obstructive pulmonary disease (COPD) patients specially. Our aim is to verify that whether the Bulpa criteria are the most suitable for diagnosing probable IPA in critically ill COPD patients compared with the other two criteria. METHODS: We included critically ill COPD patients admitted to the ICU from April 2006 to August 2013...
March 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28289034/the-impact-of-mucositis-on-absorption-and-systemic-drug-exposure-of-isavuconazole
#8
Laura L Kovanda, Francisco M Marty, Johan Maertens, Amit V Desai, Christopher Lademacher, Marc Engelhardt, Qiaoyang Lu, William W Hope
Isavuconazonium sulfate is the water-soluble prodrug of isavuconazole. Population analyses have demonstrated relatively predictable pharmacokinetic (PK) behavior in diverse patient populations. We evaluated the impact of mucositis on the oral isavuconazole exposure using population PK modeling. METHODS: We evaluated patients treated in two phase 3 trials of isavuconazole, SECURE for treatment of invasive aspergillosis (IA) and other filamentous fungi and VITAL for patients with mucormycosis, invasive fungal disease (IFD) caused by other rare fungi, or IA and renal impairment...
March 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28278704/incidence-etiology-and-timing-of-infections-following-azacitidine-therapy-for-myelodysplastic-syndromes
#9
Jason A Trubiano, Michael Dickinson, Karin A Thursky, Timothy Spelman, John F Seymour, Monica A Slavin, Leon J Worth
We examine the infective complications occurring during azacitidine (AZA) therapy in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). A retrospective review of patients receiving ≥1 cycle of AZA for MDS or AML was performed. Patient demographics, infection prophylaxis/episodes and outcomes were evaluated. Sixty eight patients received 884 AZA cycles. Bacterial infections occurred in 25% of cycle-1 and 27% of cycle-2 AZA therapy. Febrile neutropenia complicated 5.3% of AZA cycles, bacteremia 2% and invasive Aspergillosis 0...
February 28, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28275535/invasive-pulmonary-aspergillosis-in-a-steroid-dependent-asthmatic
#10
Bibi Aneesah Jaumally, Ahmed M Salem, Ala Eddin Sagar, George Pyrgos
No abstract text is available yet for this article.
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28275471/immunity-status-of-invasive-pulmonary-aspergillosis-patients-with-structural-lung-diseases-in-chinese-adults
#11
Shuo Liang, Rong Jiang, Hai-Wen Lu, Bei Mao, Man-Hui Li, Cheng-Wei Li, Shu-Yi Gu, Jiu-Wu Bai, Jin-Fu Xu
BACKGROUND: Invasive pulmonary aspergillosis (IPA) is a fungal infection frequently observed in patients with immune dysfunction, such as those suffering from structural lung diseases. Nevertheless, studies assessing IPA combined with other common respiratory diseases remain scarce, particularly those regarding the immune status of its patients. Different structural lung diseases are known to differently affect patient immune status; however, the mechanisms by which this is conferred have yet to be determined...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28270451/validation-of-single-nucleotide-polymorphisms-in-invasive-aspergillosis-following-hematopoietic-cell-transplantation
#12
Cynthia E Fisher, Tobias M Hohl, Wenhong Fan, Barry E Storer, David M Levine, Lu Ping Zhao, Paul J Martin, Edus H Warren, Michael Boeckh, John A Hansen
Invasive aspergillosis (IA) is a significant cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Previous studies have reported an association between IA development and single nucleotide polymorphisms (SNPs), but many have not been replicated in a separate cohort. The presence of a positive serum galactomannan assay (SGM+) has also been associated with a worse prognosis in patients with IA, and genetic determinants in this subset of patients have not been systematically studied...
March 7, 2017: Blood
https://www.readbyqxmd.com/read/28265376/slowly-progressive-invasive-rhino-orbito-cerebral-aspergillosis-case-report-and-literature-review
#13
Giselle de Martin Truzzi, Henrique Furlan Pauna, Igor Moreira Hazboun, Igor Benedick Coimbra, Emerson Taro Inoue Sakuma, Icléia Siqueira Barreto, Carlos Takahiro Chone, Eulalia Sakano
This is a report of a patient with aspergillosis infection, which was thought to be a tumoral lesion during its investigation. This is not a common disease in Western countries, and this report should increase our awareness for differential diagnosis of nasal masses. Early diagnosis is desired in order to increase the survival rates.
March 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28264849/genetic-diversity-and-in-vitro-antifungal-susceptibility-of-200-clinical-and-environmental-aspergillus-flavus-isolates
#14
Mojtaba Taghizadeh-Armaki, Mohammad Taghi Hedayati, Saham Ansari, Saeed Mahdavi Omran, Sasan Saber, Haleh Rafati, Jan Zoll, Henrich A van der Lee, Willem J G Melchers, Paul E Verweij, Seyedmojtaba Seyedmousavi
Aspergillus flavus has been frequently reported as the leading cause of invasive aspergillosis in certain tropical and sub-tropical countries.Two hundred A. flavus strains originating from clinical and environmental sources and collected between 2008 and 2015 were phylogenetically identified at the species level by analyzing partial β-tubulin and calmodulin genes. In vitro antifungal susceptibility testing was performed against antifungals using the EUCAST (European Committee on Antimicrobial Susceptibility Testing) broth microdilution method...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28260935/post-influenza-aspergillosis-do-not-underestimate-influenza-b
#15
REVIEW
Eric Fl Nulens, Marc Jc Bourgeois, Marijke Bml Reynders
Our objective is to highlight and focus on post-influenza aspergillosis, triggered by influenza B virus. This relatively new clinical entity is often associated with a fulminant course of respiratory decline and high mortality. A 51-year immunocompetent woman, without any medical history or risk factors for developing a complicated influenza infection, was admitted to the intensive care unit. During admission, she presented with an afebrile flu-like syndrome, myocarditis, rhabdomyolysis, multiple organ failure, and evolved to severe respiratory distress...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28259839/fatal-fungal-endocarditis-by-aspergillus-udagawae-an-emerging-cause-of-invasive-aspergillosis
#16
Atsuko Seki, Atsushi Yoshida, Yoko Matsuda, Mitsuhiro Kawata, Takashi Nishimura, Jun Tanaka, Yoshiki Misawa, Yuta Nakano, Ryoko Asami, Koji Chida, Ken Kikuchi, Tomio Arai
Aspergillus udagawae has morphological similarities to Aspergillusfumigatus; however, it shows a low susceptibility to common antifungal drugs and poor in vitro sporulation. We present the first reported case of infectious endocarditis caused by A. udagawae. An awareness of this newly described Aspergillus species is vital for further clarification.
February 8, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28255613/intensive-care-medicine-research-agenda-on-invasive-fungal-infection-in-critically-ill-patients
#17
REVIEW
Matteo Bassetti, Jose Garnacho-Montero, Thierry Calandra, Bartjan Kullberg, George Dimopoulos, Elie Azoulay, Arunaloke Chakrabarti, Daniel Kett, Cristobal Leon, Luis Ostrosky-Zeichner, Maurizio Sanguinetti, Jean-Francois Timsit, Malcom D Richardson, Andrew Shorr, Oliver A Cornely
PURPOSE: To describe concisely the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to Candida and Aspergillus infections in non-neutropenic patients in the ICU setting. METHODS: A systematic review of the medical literature taking account of national and international guidelines and expert opinion...
March 2, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28254599/invasive-orbital-apex-aspergillosis-with-mycotic-aneurysm-formation-and-subarachnoid-hemorrhage-in-immunocompetent-patients
#18
Saleh S Baeesa, Mohamad Bakhaidar, Naushad A B Ahamed, Tariq A Madani
BACKGROUND: Invasive orbital apex aspergillosis (IOAA) is an aggressive form of aspergillus infection that usually affects immunocompromised patients. It can cause orbital apex syndrome and, if not treated promptly, may progress rapidly causing fatal complications. Subarachnoid hemorrhage (SAH) secondary to ruptured mycotic aneurysms is a very rare complication of invasive aspergillosis. We aim to describe our management and the outcome of six immunocompetent patients with IOAA with subsequent SAH secondary to ruptured mycotic aneurysms...
February 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28243080/mir-344b-1-3p-targets-tlr2-and-negatively-regulates-tlr2-signaling-pathway
#19
Hong Xu, Yuting Wu, Li Li, Weifeng Yuan, Deming Zhang, Qitao Yan, Zhenhui Guo, Wenjie Huang
OBJECTIVES: COPD is an abnormal inflammatory response characterized by decreased expression of TLR2 in patients, which is suggested to induce invasive pulmonary aspergillosis (IPA). MicroRNAs (miRNAs) have been shown to play important roles in the pathogenesis of human respiratory system disorders. Therefore, the aim of this study was to identify the miRNAs involved in the regulation of TLR2 signaling in COPD. MATERIALS AND METHODS: miRNA microarray analysis was performed to screen for the dysregulated miRNAs in alveolar macrophages (AMs) isolated from COPD rats...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28238781/caspofungin-exposure-alters-the-core-septin-aspb-interactome-of-aspergillus-fumigatus
#20
José M Vargas-Muñiz, Hilary Renshaw, Greg Waitt, Erik J Soderblom, M Arthur Moseley, Jonathan M Palmer, Praveen R Juvvadi, Nancy P Keller, William J Steinbach
Aspergillus fumigatus, the main etiological agent of invasive aspergillosis, is a leading cause of death in immunocompromised patients. Septins, a conserved family of GTP-binding proteins, serve as scaffolding proteins to recruit enzymes and key regulators to different cellular compartments. Deletion of the A. fumigatus septin aspB increases susceptibility to the echinocandin antifungal caspofungin. However, how AspB mediates this response to caspofungin is unknown. Here, we characterized the AspB interactome under basal conditions and after exposure to a clinically relevant concentration of caspofungin...
April 1, 2017: Biochemical and Biophysical Research Communications
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