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https://www.readbyqxmd.com/read/28098273/high-definition-infrared-chemical-imaging-of-colorectal-tissue-using-a-spero-qcl-microscope
#1
B Bird, J Rowlette
Mid-infrared microscopy has become a key technique in the field of biomedical science and spectroscopy. This label-free, non-destructive technique permits the visualisation of a wide range of intrinsic biochemical markers in tissues, cells and biofluids by detection of the vibrational modes of the constituent molecules. Together, infrared microscopy and chemometrics is a widely accepted method that can distinguish healthy and diseased states with high accuracy. However, despite the exponential growth of the field and its research world-wide, several barriers currently exist for its full translation into the clinical sphere, namely sample throughput and data management...
January 18, 2017: Analyst
https://www.readbyqxmd.com/read/28096746/from-english-to-chinese-japanese-and-russian-extending-research-visibility-with-language-translations-of-a-conference-slide-presentation
#2
Lilian Hoffecker, Dana Abbey
OBJECTIVE: The research demonstrates that a conference slide presentation translated into non-English languages reaches significantly larger and different audiences than an English presentation alone. METHODS: The slides of a presentation from the Medical Library Association annual meeting were translated from English to Chinese, Japanese, and Russian and posted along with the English version to SlideShare, an open slide-hosting website. View counts, traffic sources, and geographic origins of the traffic for each language version were tracked over a twenty-two-month period...
January 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28096704/neonatal-resuscitation-advances-in-training-and-practice
#3
REVIEW
Taylor Sawyer, Rachel A Umoren, Megan M Gray
Each year in the US, some four hundred thousand newborns need help breathing when they are born. Due to the frequent need for resuscitation at birth, it is vital to have evidence-based care guidelines and to provide effective neonatal resuscitation training. Every five years, the International Liaison Committee on Resuscitation (ILCOR) reviews the science of neonatal resuscitation. In the US, the American Heart Association (AHA) develops treatment guidelines based on the ILCOR science review, and the Neonatal Resuscitation Program (NRP) translates the AHA guidelines into an educational curriculum...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28096512/papers-of-note-in-science-translational-medicine-9-372
#4
Leslie K Ferrarelli
This week's papers describe new therapeutic avenues to kill tumor-initiating cells in breast, ovarian, and lung cancer patients; mitigate graft-versus-host disease after hematopoietic cell transplants in leukemia patients; and stimulate bone healing in diabetic patients.
January 17, 2017: Science Signaling
https://www.readbyqxmd.com/read/28095647/new-generation-mass-spectrometry-expands-the-toolbox-of-cell-and-developmental-biology
#5
REVIEW
Camille Lombard-Banek, Erika P Portero, Rosemary M Onjiko, Peter Nemes
Systems cell biology understanding of development requires characterization of all the molecules produced in the biological system. Decades of research and new-generation sequencing provided functional information on key genes and transcripts. However, there is less information available on how differential gene expression translates into the domains of functionally important proteins, peptides, and metabolites, and how changes in these molecules impact development. Mass spectrometry (MS) is the current technology of choice for the detection and quantification of large numbers of proteins and metabolites, because it requires no use of antibodies, functional probes, or a priori knowledge of molecules produced in the system...
January 17, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28095211/social-networking-in-an-agricultural-research-center-using-data-to-enhance-outcomes
#6
Mary E Cramer, Ozgur M Araz, Mary J Wendl
The purpose of this article is to present a case study of one Midwestern Agricultural Center that used social network analysis (SNA) to 1) evaluate its collaborations with extramural stakeholders and 2) strategically plan for extending outreach for goal achievement. An evaluation team developed a data collection instrument based on SNA principles. It was administered to the Agricultural Center's intramural stakeholders (N = 9), who were asked to identify the key extramural stakeholders with whom they had collaborated within the previous 12 months...
January 17, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28094587/applying-theories-to-better-understand-socio-political-challenges-in-implementing-evidence-based-work-disability-prevention-strategies
#7
Christian Ståhl, Katia Costa-Black, Patrick Loisel
PURPOSE: This article explores and applies theories for analyzing socio-political aspects of implementation of work disability prevention (WDP) strategies. METHOD: For the analysis, theories from political science are explained and discussed in relation to case examples from three jurisdictions (Sweden, Brazil and Québec). RESULTS: Implementation of WDP strategies may be studied through a conceptual framework that targets: (1) the institutional system in which policy-makers and other stakeholders reside; (2) the ambiguity and conflicts regarding what to do and how to do it; (3) the bounded rationality, path dependency and social systems of different stakeholders; and (4) coalitions formed by different stakeholders and power relations between them...
January 17, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28093866/advancing-clinical-and-translational-science
#8
EDITORIAL
John A Wagner
The vision for the 2015-2020 American Society for Clinical Pharmacology and Therapeutics (ASCPT) strategic plan is that ASCPT's influence and leadership make it the authority on the science and practice of translational medicine, building on a foundation of clinical pharmacology and therapeutics [http://www.ascpt.org/About-ASCPT/ASCPT-Strategic-Plan]. The vision for Clinical and Translational Science (CTS) is well-suited for ASCPT.(1) Our vision is to become the beacon and organizing principle for the field of translational medicine, as well as to provide a vehicle for ASCPT member publications...
January 16, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28090566/large-animal-models-the-key-to-translational-discovery-in-digestive-disease-research
#9
Amanda Ziegler, Liara Gonzalez, Anthony Blikslager
Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent, models, large animal models provide a number of translational advantages. The pig, in particular, is arguably one of the most powerful models of human organ systems, including the gastrointestinal tract. The pig has provided important tools and insight into intestinal ischemia/reperfusion injury, intestinal mucosal repair, as well as new insights into esophageal injury and repair...
November 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28079492/working-with-instruments-ernst-mach-as-material-epistemologist-a-short-introduction
#10
Christoph Hoffmann, Alexandre Métraux
With the death of Ernst Mach on February 19, 1916, one day after his seventy-eighth birthday, a question finally became explicit that had been looming for some time. It was as simple as it was fundamental: who, in the end, was this man, a scientist or a philosopher? The importance of this question for contemporaries can easily be gleaned from the obituaries that appeared in the weeks following Mach's death: one in the Physikalische Zeitschrift, written by Albert Einstein, and another in the Archiv für die Geschichte der Philosophie, written by Mach's former student Heinrich Gomperz...
December 2016: Science in Context
https://www.readbyqxmd.com/read/28077318/alcohol-microbiome-life-style-influence-alcohol-and-non-alcoholic-organ-damage
#11
REVIEW
Manuela G Neuman, Samuel W French, Samir Zakhari, Stefen Malnick, Helmut K Seitz, Lawrence B Cohen, Mikko Salaspuro, Andreea Voinea Griffin, Andrei Barasch, Irina A Kirpich, Paul G Thomes, Laura W Schrum, Terrence M Donohue, Kusum Kharbanda, Marcus Cruz, Mihai Opris
This paper is based upon the "8th Charles Lieber's Satellite Symposium" organized by Manuela G. Neuman at the Research Society on Alcoholism Annual Meeting, onJune 25, 2016 at New Orleans, Louisiana, USA. The integrative symposium investigated different aspects of alcohol-induced liver disease (ALD) as well as non-alcohol-induced liver disease (NAFLD) and possible repair. We revealedthe basic aspects of alcohol metabolism that may be responsible for the development of liver diseaseas well as the factors that determine the amount, frequency and which type of alcohol misuse leads to liver and gastrointestinal diseases...
January 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28074008/papers-of-note-in-science-translational-medicine-9-371
#12
Leslie K Ferrarelli
This week's articles show that targeting the receptor PAR4 may be a safe antiplatelet agent and that a live cell-based therapy stimulates wound healing in leg ulcers.
January 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/28072758/how-to-escape-the-immune-response-what-tumours-have-to-teach-to-transplant-immunologists
#13
Guillaume Claisse, Olivier Thaunat, Christiane Mousson, Kathryn J Wood, Gérard Rifle, Christophe Mariat
Recent progress in deciphering the mechanisms underlying the concepts of tumor immunosurveillance and immunoevasion has opened new opportunities for the development of effective anti-tumor therapies. Transplant physicians and immunologists have much to learn from those direct clinical translations of basic science. The 2016 Beaune Seminar in Transplant research brought together researchers from both fields to explore and discuss significant advances in cancer biology, immunotherapies and their potential impacts for the management of cancer in transplant recipients...
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28069037/health-and-genetic-ancestry-testing-time-to-bridge-the-gap
#14
Andrew Smart, Deborah A Bolnick, Richard Tutton
BACKGROUND: It is becoming increasingly difficult to keep information about genetic ancestry separate from information about health, and consumers of genetic ancestry tests are becoming more aware of the potential health risks associated with particular ancestral lineages. Because some of the proposed associations have received little attention from oversight agencies and professional genetic associations, scientific developments are currently outpacing governance regimes for consumer genetic testing...
January 9, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28067312/adeno-associated-virus-serotype-rh-10-displays-strong-muscle-tropism-following-intraperitoneal-delivery
#15
Jianzhong Ai, Jia Li, Dominic J Gessler, Qin Su, Qiang Wei, Hong Li, Guangping Gao
Recombinant adeno-associated virus (rAAV) is an attractive tool for basic science and translational medicine including gene therapy, due to the versatility in its cell and organ transduction. Previous work indicates that rAAV transduction patterns are highly dependent on route of administration. Based on this relationship, we hypothesized that intraperitoneal (IP) administration of rAAV produces unique patterns of tissue tropism. To test this hypothesis, we investigated the transduction efficiency of 12 rAAV serotypes carrying an enhanced green fluorescent protein (EGFP) reporter gene in a panel of 12 organs after IP injection...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28067031/informed-consent-the-case-of-%C3%A2-omics%C3%A2-literacy
#16
Marilyn Hammer
The world of “-omics” is vastly changing the landscape of accelerated research and its translation to patient care. Understanding this complex science, particularly in the world of oncogenomics, can be daunting. Questions arise pertaining to how nurses can best educate patients who are forced to make difficult decisions without fully understanding to what they are consenting. This article follows a patient story that drives home the need to improve -omics literacy.
6, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28065736/long-term-outcomes-of-bariatric-surgery-in-adolescents-with-severe-obesity-fabs-5-a-prospective-follow-up-analysis
#17
Thomas H Inge, Todd M Jenkins, Stavra A Xanthakos, John B Dixon, Stephen R Daniels, Meg H Zeller, Michael A Helmrath
BACKGROUND: Little is known about the long-term outcomes of bariatric surgery for severe adolescent obesity, raising questions about the durability of early responses to surgery. We aimed to analyse long-term (>5 years) outcomes of Roux-en-Y gastric bypass in a cohort of young adults who had undergone the operation during adolescence, in the Follow-up of Adolescent Bariatric Surgery at 5 Plus Years (FABS-5+) extension study. METHODS: A cohort of young people aged 13-21 years underwent Roux-en-Y gastric bypass for clinically severe obesity at a paediatric academic medical centre in the USA...
January 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28062823/health-extension-and-clinical-and-translational-science-an-innovative-strategy-for-community-engagement
#18
Arthur Kaufman, Robert L Rhyne, Juliana Anastasoff, Francisco Ronquillo, Marnie Nixon, Shiraz Mishra, Charlene Poola, Janet Page-Reeves, Carolina Nkouaga, Carla Cordova, Richard S Larson
Health Extension Regional Officers (HEROs) through the University of New Mexico Health Sciences Center (UNMHSC) help to facilitate university-community engagement throughout New Mexico. HEROs, based in communities across the state, link priority community health needs with university resources in education, service, and research. Researchers' studies are usually aligned with federal funding priorities rather than with health priorities expressed by communities. To help overcome this misalignment, the UNM Clinical and Translational Science Center (CTSC) provides partial funding for HEROs to bridge the divide between research priorities of UNMHSC and health priorities of the state's communities...
January 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28057368/genomic-translational-research-paving-the-way-to-individualized-cardiac-functional-analyses-and-personalized-cardiology
#19
REVIEW
Ares Pasipoularides
For most of Medicine's past, the best that physicians could do to cope with disease prevention and treatment was based on the expected response of an average patient. Currently, however, a more personalized/precise approach to cardiology and medicine in general is becoming possible, as the cost of sequencing a human genome has declined substantially. As a result, we are witnessing an era of precipitous advances in biomedicine and bourgeoning understanding of the genetic basis of cardiovascular and other diseases, reminiscent of the resurgence of innovations in physico-mathematical sciences and biology-anatomy-cardiology in the Renaissance, a parallel time of radical change and reformation of medical knowledge, education and practice...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28057335/big-data-science-a-literature-review-of-nursing-research-exemplars
#20
Bonnie L Westra, Martha Sylvia, Elizabeth F Weinfurter, Lisiane Pruinelli, Jung In Park, Dianna Dodd, Gail M Keenan, Patricia Senk, Rachel L Richesson, Vicki Baukner, Christopher Cruz, Grace Gao, Luann Whittenburg, Connie W Delaney
BACKGROUND: Big data and cutting-edge analytic methods in nursing research challenge nurse scientists to extend the data sources and analytic methods used for discovering and translating knowledge. PURPOSE: The purpose of this study was to identify, analyze, and synthesize exemplars of big data nursing research applied to practice and disseminated in key nursing informatics, general biomedical informatics, and nursing research journals. METHODS: A literature review of studies published between 2009 and 2015...
December 8, 2016: Nursing Outlook
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