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https://www.readbyqxmd.com/read/29774314/surgical-highlights-from-the-40-th-san-antonio-breast-cancer-symposium-5-9-december-2017-san-antonio-texas
#1
Enver Özkurt
This year San Antonio Breast Cancer Symposium (SABCS) celebrated its 40th anniversary. As in the past years, this year's conference was held in Henry B. Gonzalez Convention Centre, San Antonio, Texas, on 5-9 December 2017. The conference highlighted many different topic on breast cancer including basic science, translational research, local therapies, systemic therapies, survivorship, early clinical trials, and surgical topics. Even though SABCS evolved towards basic science and systemic therapy based manner in recent years, there were some important topics about local therapies and surgical approach...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29771621/tissue-preservation-with-mass-spectroscopic-analysis-implications-for-cancer-diagnostics
#2
O Morgan Hall, Cody J Peer, William D Figg
Surgical intervention is a common treatment modality for localized cancer. Post-operative analysis involves evaluation of surgical margins to assess whether all malignant tissue has been resected because positive surgical margins lead to a greater likelihood of recurrence. Secondary treatments are utilized to minimize the negative effects of positive surgical margins. Recently, in Science Translational Medicine, Zhang et al describe a new mass spectroscopic technique that could potentially decrease the likelihood of positive surgical margins...
May 17, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29771595/mainstreaming-implementation-science-into-immunization-systems-in-the-decade-of-vaccines-a-programmatic-imperative-for-the-african-region
#3
Abdu A Adamu, Aishatu L Adamu, Abdulkarim I Dahiru, Olalekan A Uthman, Charles S Wiysonge
Several innovations that can improve immunization systems already exist. Some interventions target service consumers within communities to raise awareness, build trust, improve understanding, remind caregivers, reward service users, and improve communication. Other interventions target health facilities to improve access and quality of vaccination services among others. Despite available empirical evidence, there is a delay in translating innovations into routine practice by immunization programmes. Drawing on an existing implementation science framework, we propose an interactive, and multi-perspective model to improve uptake and utilization of available immunization-related innovations in the African region...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29770804/publication-trends-in-spine-research-from-2007-to-2016-comparison-of-the-orthopaedic-research-society-spine-section-and-the-international-society-for-the-study-of-the-lumbar-spine
#4
John T Martin, Sarah E Gullbrand, Aaron J Fields, Devina Purmessur, Ashish D Diwan, Thomas R Oxland, Kazuhiro Chiba, Farshid Guilak, Judith A Hoyland, James C Iatridis
This study investigated current trends in spine publications of the membership of Orthopaedic Research Society Spine Section (ORS3) and the more global and clinically focused International Society for the Study of the Lumbar Spine (ISSLS). The PubMed database was probed to quantify trends in the overall number of articles published, the number of journals these articles were published in, and the number of active scientists producing new manuscripts. We also evaluated trends in flagship spine journals ( Spine , European Spine Journal , and The Spine Journal ) and in the Journal of Orthopaedic Research...
March 2018: JOR spine
https://www.readbyqxmd.com/read/29765574/psychometric-properties-of-self-assessment-clinical-competency-questionnaire-in-baccalaureate-nursing-students
#5
Batool Nehrir, Abbas Ebadi, Zohreh Vanaki, Jamileh Mokhtari Nouri, Seyed Mohammad Khademolhosseini
Background: One of the main challenges of nursing student education is the lack of clinical competence that reduces the quality of patients care. Measuring the clinical competency of undergraduate nursing students is effective in curriculum developing, planning, and learning evaluation. Objective: To validate self-assessment clinical competence questionnaire of undergraduate nursing students. Methods: This was a cross-sectional study at Baqiyatallah University of Medical Sciences in Tehran, Iran, 2015-2016...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29764540/-2018-national-consensus-on-cardiopulmonary-resuscitation-training-in-china
#6
Lixiang Wang, Qingyi Meng, Tao Yu
To promote the technical training and scientific popularization of cardiopulmonary resuscitation (CPR) in China, the Cardiopulmonary Resuscitation Specialized Committee of Chinese Research Hospital Association combined with the Science Popularization Branch of the Chinese Medical Association wrote "2018 National consensus on cardiopulmonary resuscitation training in China". The formation was based on the general outline about "2016 National consensus on cardiopulmonary resuscitation in China", and to implement the important strategies included the "three pre" policy, prevention, precognition, and pre-warning, before the cardiac arrest (CA); the "three modernization" methods, standardized, diversified and individualized, during the CA; and the "three life" strategies, the rebirth, the extra and the extended, after the CA; and also combined with the concrete National conditions and clinical practice of China area...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764101/shaping-policy-change-in-population-health-policy-entrepreneurs-ideas-and-institutions
#7
Daniel Béland, Tarun R Katapally
Political realities and institutional structures are often ignored when gathering evidence to influence population health policies. If these policies are to be successful, social science literature on policy change should be integrated into the population health approach. In this contribution, drawing on the work of John W. Kingdon and related scholarship, we set out to examine how key components of the policy change literature could contribute towards the effective development of population health policies...
January 14, 2018: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29763318/on-the-peculiar-molecular-shape-and-size-dependence-of-the-dynamics-of-fluids-confined-in-a-small-pore-metal-organic-framework
#8
Ioannis Skarmoutsos, Mohamed Eddaoudi, Guillaume Maurin
Force field based-Molecular dynamics simulations were deployed to systematically explore the dynamics of confined molecules of different shapes and sizes, i.e. linear (CO2 and N2) and spherical (CH4) fluids, in a model small pore system, i.e. the Metal-Organic Framework SIFSIX-2-Cu-i. These computations unveil an unprecedented molecular symmetry dependence of the translational and rotational dynamics of fluids confined in channel-like nanoporous materials. In particular this peculiar behaviour is reflected by the extremely slow decay of the Legendre reorientational correlation functions of even-parity order for the linear fluids which is associated to jump-like orientation flips, while the spherical fluid shows a very fast decay taking place in a sub-picosecond time scale...
May 15, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29762088/an-updated-taxonomy-and-a-graphical-summary-tool-for-optimal-classification-and-comprehension-of-omics-research
#9
Nina Pirih, Tanja Kunej
The volume of publications and the type of research approaches used in omics system sciences are vast and continue to expand rapidly. This increased complexity and heterogeneity of omics data are challenging data extraction, sensemaking, analyses, knowledge translation, and interpretation. An extended and dynamic taxonomy for the classification and summary of omics studies are essential. We present an updated taxonomy for classification of omics research studies based on four criteria: (1) type and number of genomic loci in a research study, (2) number of species and biological samples, (3) the type of omics technology (e...
May 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29761708/the-potential-of-interprofessional-education-to-translate-physiology-curricula-effectively-into-future-team-based-healthcare
#10
Scott Edwards, Patricia E Molina, Kathleen H McDonough, Donald E Mercante, Tina Patel Gunaldo
Incorporating active interprofessional education (IPE) opportunities into the classroom setting is a potentially effective mechanism to enhance student learning both in the basic sciences and for future interprofessional collaboration. We integrated an IPE exercise into a graduate-level human physiology course at our health sciences center that enrolled physician assistant (PA), physical therapy (PT), and graduate studies students. Our activity adopted and targeted the four Interprofessional Education Collaborative (IPEC) competency domains of values/ethics (VE), roles/responsibilities, interprofessional communication, and teams and teamwork (TT)...
June 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29759032/tim-3-expressing-mast-cells-are-present-in-chronic-rhinosinusitis-with-nasal-polyps
#11
Erica Corredera, Binh L Phong, John A Moore, Lawrence P Kane, Stella E Lee
Objectives To identify whether TIM-3 expression is present in the mast cell population within nasal polyps and to determine its correlation with clinical severity in patients with chronic rhinosinusitis with nasal polyposis. Study Design Basic science, translational study. Setting Nasal polyp tissue collected from patients seen at a tertiary care hospital (2015-2016). Subjects and Methods Nasal polyp tissue obtained during functional endoscopic sinus surgery (n = 24) was enzymatically digested into epithelial and stromal fractions...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29756991/the-immune-landscape-of-non-small-cell-lung-cancer-utility-of-cytologic-and-histologic-samples-obtained-through-minimally-invasive-pulmonary-procedures
#12
Jason Beattie, Lonny Yarmus, Momen Wahidi, M Patricia Rivera, Christopher Gilbert, Fabien Maldonado, Kasia Czarnecka, Angela Argento, Alexander Chen, Felix Herth, Daniel H Sterman
The success of immune checkpoint inhibitors and the discovery of useful biomarkers to predict response to these agents has shifted much of the focus of personalized care for advanced non-small cell lung cancer towards harnessing the immune response. With further advancement, more effective immunotherapy options will emerge along with more useful biomarkers. For patients with advanced disease, minimally invasive techniques will remain most appropriate for acquisition of tissue. This is in contrast to default gold-standard large tissue specimens obtained through surgical resection...
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29755172/retrospective-review-of-student-research-projects-in-a-canadian-master-of-science-in-physical-therapy-programme-and-the-perceived-impact-on-advisors-research-capacity-education-clinical-practice-knowledge-translation-and-health-policy
#13
Courtney Lacey, Stephanie Scodras, Julie Ardron, Ryan Sellan, Martyna Garbaczewska, Kelly K O'Brien, Nancy M Salbach
Purpose: This study's aim was to characterize the nature of students' research conducted for a Master of Science in Physical Therapy (MScPT) degree programme at a Canadian university and evaluate the lead advisors' perspectives of its impact on their research capacity, education, clinical practice, knowledge translation, and health policy. Methods: We conducted a quantitative, cross-sectional, retrospective review of research reports from 2003 to 2014 to characterize the MScPT students' research and a quantitative, cross-sectional e-survey of lead research advisors to evaluate the impact of this research...
2018: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/29753798/sex-related-responses-after-traumatic-brain-injury-considerations-for-preclinical-modeling
#14
REVIEW
Claudia B Späni, David J Braun, Linda J Van Eldik
Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since men are more likely to experience a TBI because of more frequent participation in activities that increase risk of head injuries. This male bias is also reflected in preclinical research where mostly male animals have been used in basic and translational science. However, with an aging population in which TBI incidence is increasingly sex-independent due to falls, and increasing female participation in high-risk activities, the attention to potential sex differences in TBI responses and outcomes will become more important...
May 10, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29752217/mass-spectrometric-identification-of-urinary-biomarkers-of-pulmonary-tuberculosis
#15
Flonza Isa, Sean Collins, Myung Hee Lee, Diessy Decome, Nancy Dorvil, Patrice Joseph, Lauren Smith, Stephen Salerno, Martin T Wells, Steven Fischer, James M Bean, Jean W Pape, Warren D Johnson, Daniel W Fitzgerald, Kyu Y Rhee
BACKGROUND: Tuberculosis (TB) is the leading infectious cause of death worldwide. A major barrier to control of the pandemic is a lack of clinical biomarkers with the ability to distinguish active TB from healthy and sick controls and potential for development into point-of-care diagnostics. METHODS: We conducted a prospective case control study to identify candidate urine-based diagnostic biomarkers of active pulmonary TB (discovery cohort) and obtained a separate blinded "validation" cohort of confirmed cases of active pulmonary TB and controls with non-tuberculous pulmonary disease for validation...
April 22, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29751612/advice-and-frequently-asked-questions-faqs-for-citizen-science-environmental-health-assessments
#16
Timothy M Barzyk, Hongtai Huang, Ronald Williams, Amanda Kaufman, Jonathan Essoka
Citizen science provides quantitative results to support environmental health assessments (EHAs), but standardized approaches do not currently exist to translate findings into actionable solutions. The emergence of low-cost portable sensor technologies and proliferation of publicly available datasets provides unparalleled access to supporting evidence; yet data collection, analysis, interpretation, visualization, and communication are subjective approaches that must be tailored to a decision-making audience capable of improving environmental health...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29751523/annexin-a1-and-autoimmunity-from-basic-science-to-clinical-applications
#17
REVIEW
Maurizio Bruschi, Andrea Petretto, Augusto Vaglio, Laura Santucci, Giovanni Candiano, Gian Marco Ghiggeri
Annexin A1 is a protein with multifunctional roles in innate and adaptive immunity mainly devoted to the regulation of inflammatory cells and the resolution of inflammation. Most of the data regarding Annexin A1 roles in immunity derive from cell studies and from mice models lacking Annexin A1 for genetic manipulation (Annexin A1-/- ); only a few studies sought to define how Annexin A1 is involved in human diseases. High levels of anti-Annexin A1 autoantibodies have been reported in systemic lupus erythematosus (SLE), suggesting this protein is implicated in auto-immunity...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29751162/recent-advances-in-dna-nanotechnology
#18
REVIEW
Pongphak Chidchob, Hanadi F Sleiman
DNA is a powerful guiding molecule to achieve the precise construction of arbitrary structures and high-resolution organization of functional materials. The combination of sequence programmability, rigidity and highly specific molecular recognition in this molecule has resulted in a wide range of exquisitely designed DNA frameworks. To date, the impressive potential of DNA nanomaterials has been demonstrated from fundamental research to technological advancements in materials science and biomedicine. This review presents a summary of some of the most recent developments in structural DNA nanotechnology regarding new assembly approaches and efforts in translating DNA nanomaterials into practical use...
May 8, 2018: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29750201/3d-printing-of-a-wearable-personalized-oral-delivery-device-a-first-in-human-study
#19
Kun Liang, Simone Carmone, Davide Brambilla, Jean-Christophe Leroux
Despite the burgeoning interest in three-dimensional (3D) printing for the manufacture of customizable oral dosage formulations, a U.S. Food and Drug Administration-approved tablet notwithstanding, the full potential of 3D printing in pharmaceutical sciences has not been realized. In particular, 3D-printed drug-eluting devices offer the possibility for personalization in terms of shape, size, and architecture, but their clinical applications have remained relatively unexplored. We used 3D printing to manufacture a tailored oral drug delivery device with customizable design and tunable release rates in the form of a mouthguard and, subsequently, evaluated the performance of this system in the native setting in a first-in-human study...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29748367/pcsk9-from-basic-science-discoveries-to-clinical-trials
#20
REVIEW
Michael D Shapiro, Hagai Tavori, Sergio Fazio
Unknown 15 years ago, PCSK9 (proprotein convertase subtilisin/kexin type 9) is now common parlance among scientists and clinicians interested in prevention and treatment of atherosclerotic cardiovascular disease. What makes this story so special is not its recent discovery nor the fact that it uncovered previously unknown biology but rather that these important scientific insights have been translated into an effective medical therapy in record time. Indeed, the translation of this discovery to novel therapeutic serves as one of the best examples of how genetic insights can be leveraged into intelligent target drug discovery...
May 11, 2018: Circulation Research
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