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https://www.readbyqxmd.com/read/28816904/the-relationship-between-oref-grants-and-future-nih-funding-success
#1
Vishal Hegde, Daniel Johansen, Howard Y Park, Stephen D Zoller, Christopher Hamad, Nicholas M Bernthal
BACKGROUND: The Orthopaedic Research and Education Foundation (OREF) is the leading specialty-specific nongovernmental organization providing orthopaedic funding in the United States. As extramural research funding has become increasingly difficult to acquire, one mission of the OREF is to support investigators to generate data needed to secure larger extramural funding from agencies such as the National Institutes of Health (NIH). The objectives of this study were to evaluate the rate of translating OREF faculty-level grants into subsequent NIH funding and to determine if there are identifiable factors that increase the rate of converting an OREF grant into NIH funding...
August 16, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28814732/dual-contrast-magnetic-resonance-fingerprinting-dc-mrf-a-platform-for-simultaneous-quantification-of-multiple-mri-contrast-agents
#2
Christian E Anderson, Shannon B Donnola, Yun Jiang, Joshua Batesole, Rebecca Darrah, Mitchell L Drumm, Susann M Brady-Kalnay, Nicole F Steinmetz, Xin Yu, Mark A Griswold, Chris A Flask
Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a single agent at a time...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814664/pulmonary-arterial-hypertension-treatment-with-carvedilol-for-heart-failure-a-randomized-controlled-trial
#3
Samar Farha, Didem Saygin, Margaret M Park, Hoi I Cheong, Kewal Asosingh, Suzy Aa Comhair, Olivia R Stephens, Emir C Roach, Jacqueline Sharp, Kristin B Highland, Frank P DiFilippo, Donald R Neumann, W H Wilson Tang, Serpil C Erzurum
BACKGROUND: Right-sided heart failure is the leading cause of death in pulmonary arterial hypertension (PAH). Similar to left heart failure, sympathetic overactivation and β-adrenoreceptor (βAR) abnormalities are found in PAH. Based on successful therapy of left heart failure with β-blockade, the safety and benefits of the nonselective β-blocker/vasodilator carvedilol were evaluated in PAH. METHODS: PAH Treatment with Carvedilol for Heart Failure (PAHTCH) is a single-center, double-blind, randomized, controlled trial...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28814473/breaking-boundaries-optimizing-reconsolidation-based-interventions-for-strong-and-old-memories
#4
James W B Elsey, Merel Kindt
Recent research has demonstrated that consolidated memories can enter a temporary labile state after reactivation, requiring restabilization in order to persist. This process, known as reconsolidation, potentially allows for the modification and disruption of memory. Much interest in reconsolidation stems from the possibility that maladaptive memory traces-a core feature of several psychiatric conditions-could be tackled by disrupting their reconsolidation. However, research has indicated a range of supposed boundary conditions on the induction of reconsolidation...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28814328/building-capacity-for-dissemination-and-implementation-research-one-university-s-experience
#5
Ross C Brownson, Enola K Proctor, Douglas A Luke, Ana A Baumann, Mackenzie Staub, Matthew T Brown, Mallory Johnson
BACKGROUND: While dissemination and implementation (D&I) science has grown rapidly, there is an ongoing need to understand how to build and sustain capacity in individuals and institutions conducting research. There are three inter-related domains for capacity building: people, settings, and activities. Since 2008, Washington University in St. Louis has dedicated significant attention and resources toward building D&I research capacity. This paper describes our process, challenges, and lessons with the goal of informing others who may have similar aims at their own institution...
August 16, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28812122/-how-does-knowledge-reach-health-care-practice-implementation-research-and-knowledge-circulation
#6
REVIEW
Horst Christian Vollmar, Sara Santos, Anneke de Jong, Gabriele Meyer, Stefan Wilm
BACKGROUND: Evidence-based knowledge is among the most important resources in health care. However, relevant knowledge is often not implemented. There are about 100 different concepts for the "knowledge-to-practice gap". OBJECTIVES: We conducted this review to identify relevant concepts that describe and try to overcome this situation: implementation research and knowledge translation or circulation. MATERIALS AND METHODS: We initially conducted a systematic search in the databases CINAHL, Embase, ERIC, Medline, PsycINFO, Scopus, Cochrane Library and Web of Science without time or language restrictions...
August 15, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28811702/precision-medicine-in-need-of-guidance-and-surveillance
#7
EDITORIAL
Jian-Zhen Lin, Jun-Yu Long, An-Qiang Wang, Ying Zheng, Hai-Tao Zhao
Precision medicine, currently a hotspot in mainstream medicine, has been strongly promoted in recent years. With rapid technological development, such as next-generation sequencing, and fierce competition in molecular targeted drug exploitation, precision medicine represents an advance in science and technology; it also fulfills needs in public health care. The clinical translation and application of precision medicine - especially in the prevention and treatment of tumors - is far from satisfactory; however, the aims of precision medicine deserve approval...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28811201/the-unmet-need-in-rheumatology-reports-from-the-targeted-therapies-meeting-2017
#8
Kevin L Winthrop, Vibeke Strand, Désirée van der Heijde, Philip Mease, Mary Crow, Michael Weinblatt, Joan Bathon, Gerd R Burmester, Maxime Dougados, Johnathan Kay, Xavier Mariette, Ronald Van Vollenhoven, Joachim Sieper, Fritz Melchers, Ferdinand C Breedfeld, Joachim Kalden, Josef S Smolen, Daniel E Furst
The 19th annual international Targeted Therapies meeting brought together over 100 leading basic scientists and clinical researchers from around the world in the field of immunology, molecular biology and rheumatology and other specialties. During the meeting, breakout sessions were held consisting of 5 disease-specific groups with 20-40 experts assigned to each group based on clinical or scientific expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematous, connective tissue diseases (e...
August 12, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28809446/deferasirox-for-managing-iron-overload-in-people-with-thalassaemia
#9
REVIEW
Claudia Bollig, Lisa K Schell, Gerta Rücker, Roman Allert, Edith Motschall, Charlotte M Niemeyer, Dirk Bassler, Joerg J Meerpohl
BACKGROUND: Thalassaemia is a hereditary anaemia due to ineffective erythropoiesis. In particular, people with thalassaemia major develop secondary iron overload resulting from regular red blood cell transfusions. Iron chelation therapy is needed to prevent long-term complications.Both deferoxamine and deferiprone are effective; however, a review of the effectiveness and safety of the newer oral chelator deferasirox in people with thalassaemia is needed. OBJECTIVES: To assess the effectiveness and safety of oral deferasirox in people with thalassaemia and iron overload...
August 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28809007/method-to-identify-silent-codon-mutations-that-may-alter-peptide-elongation-kinetics-and-co-translational-protein-folding
#10
Ronald Worthington, Elijah Ball, Brentsen Wolf, Gregory Takacs
Due to the redundancy of the protein genetic code, mutational changes in the second or third nucleotide of an existing codon may not change the amino acid specification of the resulting modified codon. When peptide primary sequence is unchanged by mutation, that mutation is assumed to have no functional consequences. However, for one key gene involved in drug transport, MDR-1, several silent, synonymous mutations have been shown to alter protein structure and substrate affinity (Kimchi-Sarfaty et al., Science 315:525-528, 2007)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28808089/bag3-mediated-proteostasis-at-a-glance
#11
REVIEW
Christina Klimek, Barbara Kathage, Judith Wördehoff, Jörg Höhfeld
Cellular and organismal survival depend on the ability to maintain the proteome, even under conditions that threaten protein integrity. BCL2-associated athanogene 3 (BAG3) is essential for protein homeostasis (proteostasis) in stressed cells. Owing to its multi-domain structure, it engages in diverse processes that are crucial for proteome maintenance. BAG3 promotes the activity of molecular chaperones, sequesters and concentrates misfolded proteins, initiates autophagic disposal, and balances transcription, translation and degradation...
August 14, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28806989/maximising-value-from-a-united-kingdom-biomedical-research-centre-study-protocol
#12
Trisha Greenhalgh, Pavel V Ovseiko, Nick Fahy, Sara Shaw, Polly Kerr, Alexander D Rushforth, Keith M Channon, Vasiliki Kiparoglou
BACKGROUND: Biomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country's international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) apply the evidence base on how best to support the various partnerships in this large, multi-stakeholder research system and (2) research how these partnerships play out in a new, ambitious programme of translational research...
August 14, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28806234/delirium-in-the-critically-ill-child
#13
Sharon Norman, Asma A Taha, Helen N Turner
PURPOSE/OBJECTIVE: The purposes of this article are to describe the scientific literature on assessment, prevention, and management of delirium in critically ill children and to articulate the implications for clinical nurse specialists, in translating the evidence into practice. DESCRIPTION: A literature search was conducted in 4 databases-OvidMEDLINE, Cumulative Index to Nursing and Allied Health Literature, PsychINFO, and Web of Science-using the terms "delirium," "child," and "critically ill" for the period of 2006 to 2016...
September 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/28805172/the-developmental-origins-of-health-and-disease-and-sustainable-development-goals-mapping-the-way-forward
#14
N Kajee, E Sobngwi, A Macnab, A S Daar
In this paper, meant to stimulate debate, we argue that there is considerable benefit in approaching together the implementation of two seemingly separate recent developments. First, on the global development agenda, we have the United Nations General Assembly's 2015 finalized list of 17 Sustainable Development Goals (SDGs). Several of the SDGs are related to health. Second, the field of Developmental Origins of Health and Disease (DOHaD) has garnered enough compelling evidence demonstrating that early exposures in life affect not only future health, but that the effects of that exposure can be transmitted across generations - necessitating that we begin to focus on prevention...
August 14, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28804707/framework-to-define-structure-and-boundaries-of-complex-health-intervention-systems-the-alert-project
#15
Elena Boriani, Roberto Esposito, Chiara Frazzoli, Peter Fantke, Tine Hald, Simon R Rüegg
Health intervention systems are complex and subject to multiple variables in different phases of implementation. This constitutes a concrete challenge for the application of translational science in real life. Complex systems as health-oriented interventions call for interdisciplinary approaches with carefully defined system boundaries. Exploring individual components of such systems from different viewpoints gives a wide overview and helps to understand the elements and the relationships that drive actions and consequences within the system...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28803534/moving-rehabilitation-research-forward-developing-consensus-statements-for-rehabilitation-and-recovery-research
#16
Julie Bernhardt, Karen Borschmann, Lara Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer, Tammy Hoffmann, Gert Kwakkel, Sean Savitz, Gustavo Saposnik, Marion Walker, Nick Ward
Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardized terminology is absent in both animal and human research, methods are poorly described, recovery biomarkers are not well defined, and we lack consistent timeframes or measures to examine outcomes. Agreed methods and conventions for developing, monitoring, evaluating and reporting interventions directed at improving recovery are lacking, and current approaches are often not underpinned by biology...
August 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28800754/current-concepts-in-bone-metastasis-contemporary-therapeutic-strategies-and-ongoing-clinical-trials
#17
REVIEW
Andrew S Gdowski, Amalendu Ranjan, Jamboor K Vishwanatha
BACKGROUND: Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the rapid rate of progress in both the basic science literature and therapies undergoing clinical trials makes staying abreast with current developments challenging. This review seeks to provide an update on the current state of the science in bone metastasis research and give a snap shot of therapies in clinical trials for bone metastatic cancer...
August 11, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28795530/construction-of-silica-based-micro-nanoplatforms-for-ultrasound-theranostic-biomedicine
#18
REVIEW
Yang Zhou, Xiaoxia Han, Xiangxiang Jing, Yu Chen
Ultrasound (US)-based biomedicine has been extensively explored for its applications in both diagnostic imaging and disease therapy. The fast development of theranostic nanomedicine significantly promotes the development of US-based biomedicine. This progress report summarizes and discusses the recent developments of rational design and fabrication of silica-based micro/nanoparticles for versatile US-based biomedical applications. The synthetic strategies and surface-engineering approaches of silica-based micro/nanoparticles are initially discussed, followed by detailed introduction on their US-based theranostic applications...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28795163/a-reformulation-of-mechanics-and-electrodynamics
#19
Mario J Pinheiro
Classical mechanics, as commonly taught in engineering and science, are confined to the conventional Newtonian theory. But classical mechanics has not really changed in substance since Newton formulation, describing simultaneous rotation and translation of objects with somewhat complicate drawbacks, risking interpretation of forces in non-inertial frames. In this work we introduce a new variational principle for out-of-equilibrium, rotating systems, obtaining a set of two first order differential equations that introduces a thermodynamic-mechanistic time into Newton's dynamical equation, and revealing the same formal symplectic structure shared by classical mechanics, fluid mechanics and thermodynamics...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28791282/the-global-health-service-partnership-an-academic-clinical-partnership-to-build-nursing-and-medical-capacity-in-africa
#20
REVIEW
Eileen M Stuart-Shor, Elizabeth Cunningham, Laura Foradori, Elizabeth Hutchinson, Martha Makwero, Jill Smith, Jane Kasozi, Esther M Johnston, Aliasgar Khaki, Elisa Vandervort, Fabiola Moshi, Vanessa B Kerry
The World Health Organization estimates a global deficit of about 12.9 million skilled health professionals (midwives, nurses, and physicians) by 2035. These shortages limit the ability of countries, particularly resource-constrained countries, to deliver basic health care, to respond to emerging and more complex needs, and to teach, graduate, and retain their future health professionals-a vicious cycle that is perpetuated and has profound implications for health security. The Global Health Service Partnership (GHSP) is a unique collaboration between the Peace Corps, President's Emergency Plan for AIDS Relief, Seed and host-country institutions, which aims to strengthen the breadth and quality of medical and nursing education and care delivery in places with dire shortages of health professionals...
2017: Frontiers in Public Health
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