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https://www.readbyqxmd.com/read/29305594/egbmmda-extreme-gradient-boosting-machine-for-mirna-disease-association-prediction
#1
Xing Chen, Li Huang, Di Xie, Qi Zhao
Associations between microRNAs (miRNAs) and human diseases have been identified by increasing studies and discovering new ones is an ongoing process in medical laboratories. To improve experiment productivity, researchers computationally infer potential associations from biological data, selecting the most promising candidates for experimental verification. Predicting potential miRNA-disease association has become a research area of growing importance. This paper presents a model of Extreme Gradient Boosting Machine for MiRNA-Disease Association (EGBMMDA) prediction by integrating the miRNA functional similarity, the disease semantic similarity, and known miRNA-disease associations...
January 5, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29297284/automated-classification-and-characterization-of-the-mitotic-spindle-following-knockdown-of-a-mitosis-related-protein
#2
Matloob Khushi, Imraan M Dean, Erdahl T Teber, Megan Chircop, Jonathan W Arthur, Neftali Flores-Rodriguez
BACKGROUND: Cell division (mitosis) results in the equal segregation of chromosomes between two daughter cells. The mitotic spindle plays a pivotal role in chromosome alignment and segregation during metaphase and anaphase. Structural or functional errors of this spindle can cause aneuploidy, a hallmark of many cancers. To investigate if a given protein associates with the mitotic spindle and regulates its assembly, stability, or function, fluorescence microscopy can be performed to determine if disruption of that protein induces phenotypes indicative of spindle dysfunction...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29295652/long-lasting-neuropsychological-effects-of-a-computerized-cognitive-training-in-patients-affected-by-early-stage-alzheimer-s-disease-are-they-stable-over-time
#3
Marco Cavallo, Chiara Angilletta
INTRODUCTION: We investigated the stability of effects of a computerized cognitive training previously administered to a large group of early stage Alzheimer's disease (AD) patients, as compared with a control group. METHOD: Eighty AD patients were randomized in two groups and underwent a computerized cognitive training, or a control intervention. RESULTS: A Repeated Measures General Linear Model (RM-GLM) showed a significant interaction effect for the following neuropsychological tests: the digit span forward and backward, and the two-syllable words test, as measures of short-term memory and working memory; the Rivermead Behavioural Memory Test (RBMT) story immediate and the RBMT story delayed, as measures of ecologically oriented memory; the Token test, as measure of language comprehension; and the Brixton test, as an executive functions measure...
January 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29283498/neuronal-rna-binding-protein-hud-regulates-addiction-related-gene-expression-and-behavior
#4
Robert J Oliver, Jonathan L Brigman, Federico Bolognani, Andrea M Allan, Janet L Neisewander, Nora I Perrone-Bizzozero
The neuronal RNA-binding protein HuD is involved in synaptic plasticity and learning and memory mechanisms. These effects are thought to be due to HuD-mediated stabilization and translation of target mRNAs associated with plasticity. To investigate the potential role of HuD in drug addiction, we first used bioinformatics prediction algorithms together with microarray analyses to search for specific genes and functional networks upregulated within the forebrain of HuD overexpressing mice (HuDOE ). When this set was further limited to genes in the Knowledgebase of Addiction Related Genes database (KARG) that contains predicted HuD-binding sites in their 3' untranslated regions (3' UTR), we found that HuD regulates networks that have been associated with addiction-like behavior...
December 28, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29248397/comparison-of-low-back-mobility-and-stability-exercises-from-pilates-in-non-specific-low-back-pain-a-study-protocol-of-a-randomized-controlled-trial
#5
Iã Ferreira Miranda, Catiane Souza, Alexandre Tavares Schneider, Leandro Campos Chagas, Jefferson Fagundes Loss
BACKGROUND: There is some evidence in the literature about the effectiveness of the Pilates methods in the low back pain. Moreover, Pilates focus on exercises that empathizes the stability and/or mobility of the spine. Therefore, it is discussed in the literature whether higher levels of stability or mobility of the lumbar spine generates better results, both in performance and rehabilitation for low back pain. OBJECTIVES: Compare the effects of the low back mobility and stability exercises from Pilates Method on low back pain, disability and movement functionality in individuals with non-specific chronic low back pain...
December 8, 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29238235/oppositional-defiant-disorder-current-insight
#6
REVIEW
Abhishek Ghosh, Anirban Ray, Aniruddha Basu
Oppositional defiant disorder (ODD) is diagnosed broadly on the basis of frequent and persistent angry or irritable mood, argumentativeness/defiance, and vindictiveness. Since its inception in the third Diagnostic and Statistical Manual of Mental Disorders, epidemiological and longitudinal studies have strongly suggested a distinct existence of ODD that is different from other closely related externalizing disorders, with different course and outcome and possibly discrete subtypes. However, several issues, such as symptom threshold, dimensional versus categorical conceptualization, and sex-specific symptoms, are yet to be addressed...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29234556/transversus-abdominis-activation-and-timing-improves-following-core-stability-training-a-randomized-trial
#7
Noelle M Selkow, Molly R Eck, Stephen Rivas
Background: Patients with non-specific low back pain (LBP) often present with a decrease in transversus abdominis (TrA) muscle activation and delayed onset of contraction with extremity movements, potentially contributing to recurrent LBP. Core stability is required for extremity movement and if the timing of when the TrA contracts is not corrected patients may continue to experience LBP. Hypothesis/Purpose: The purpose of this study was to assess the effects of a four-week core stability rehabilitation program on TrA activation ratio and when the TrA initiates contraction during upper extremity movements in subjects with and without LBP...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29234302/home-based-virtual-reality-augmented-training-improves-lower-limb-muscle-strength-balance-and-functional-mobility-following-chronic-incomplete-spinal-cord-injury
#8
Michael Villiger, Jasmin Liviero, Lea Awai, Rahel Stoop, Pawel Pyk, Ron Clijsen, Armin Curt, Kynan Eng, Marc Bolliger
Key factors positively influencing rehabilitation and functional recovery after spinal cord injury (SCI) include training variety, intensive movement repetition, and motivating training tasks. Systems supporting these aspects may provide profound gains in rehabilitation, independent of the subject's treatment location. In the present study, we test the hypotheses that virtual reality (VR)-augmented training at home (i.e., unsupervised) is feasible with subjects with an incomplete SCI (iSCI) and that it improves motor functions such as lower limb muscle strength, balance, and functional mobility...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29232710/stabilizing-patterns-in-time-neural-network-approach
#9
Nadav Ben-Shushan, Misha Tsodyks
Recurrent and feedback networks are capable of holding dynamic memories. Nonetheless, training a network for that task is challenging. In order to do so, one should face non-linear propagation of errors in the system. Small deviations from the desired dynamics due to error or inherent noise might have a dramatic effect in the future. A method to cope with these difficulties is thus needed. In this work we focus on recurrent networks with linear activation functions and binary output unit. We characterize its ability to reproduce a temporal sequence of actions over its output unit...
December 12, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29200632/the-effect-of-the-inspiratory-muscle-training-on-functional-ability-in-stroke-patients
#10
Nam-Jin Jung, Sang-Su Na, Seung-Kyu Kim, Gak Hwangbo
[Purpose] This study was to find out an inspiratory muscle training (IMT) program therapeutic effects on stroke patients' functional ability. [Subjects and Methods] Twenty stroke patients were assigned to one of two groups: inspiratory muscle training (n=10), and control (n=10), randomization. The inspiratory muscle training participants undertook an exercise program for 30 minute per times, 5 times a week for 6 weeks. The investigator measured the patients' trunk impairment scale (TIS) and 6 minute walking test (6MW) for functional ability before and after IMT...
November 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29193314/effects-of-wobble-board-training-on-single-leg-landing-neuromechanics
#11
Priscila de Brito Silva, Anderson Souza Castelo Oliveira, Natalie Mrachacz-Kersting, Uwe Gustav Kersting
Balance training programs have been shown to reduce ankle sprain injuries in sports, but little is known about the transfer from this training modality to motor coordination and ankle joint biomechanics in sport specific movements. This study aimed to investigate the effects of wobble board training on motor coordination and ankle mechanics during early single-leg landing from a lateral jump. Twenty-two healthy men were randomly assigned to either a control or a training group, who engaged in four weeks of wobble board training...
November 29, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29173349/position-of-the-academy-of-nutrition-and-dietetics-food-insecurity-in-the-united-states
#12
David H Holben, Michelle Berger Marshall
It is the position of the Academy of Nutrition and Dietetics that systematic and sustained action is needed to achieve food and nutrition security in the United States. To achieve food security, effective interventions are needed, along with adequate funding for, and increased utilization of, food and nutrition assistance programs; inclusion of nutrition education in such programs; strategies to support individual and household economic stability; and research to measure impact on food insecurity- and health-related outcomes...
December 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29170690/correlation-between-the-functional-movement-screen-and-hip-mobility-in-ncaa-division-ii-athletes
#13
Matthew T Jenkins, Robert Gustitus, Mike Iosia, Taz Kicklighter, Yuichi Sasaki
The Functional Movement Screen (FMS) is a series of seven exercises designed to assess athletes prior to competitive training to determine dysfunctional movement patterns. The exercises include the deep squat (DS), hurdle step (HS), inline lunge (IL), shoulder mobility (SM), active straight leg raise (ASL), pushup (PU), and rotary stability (RS), all of which comprise the composite score (FMS CS). The purpose of this study was to determine correlations between the FMS screens and hip mobility. The specific hip range-of-motion exercises used were bilateral internal/external rotation (IRR, IRL ERL, ERR), and flexion/extension (FL, FR, ER, EL)...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/29163185/orthostatic-intolerance-in-older-persons-etiology-and-countermeasures
#14
REVIEW
Nandu Goswami, Andrew P Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29154279/biological-factors-contributing-to-the-response-to-cognitive-training-in-mild-cognitive-impairment
#15
Jessica Peter, Lena V Schumacher, Verena Landerer, Ahmed Abdulkadir, Christoph P Kaller, Jacob Lahr, Stefan Klöppel
In mild cognitive impairment (MCI), small benefits from cognitive training were observed for memory functions but there appears to be great variability in the response to treatment. Our study aimed to improve the characterization and selection of those participants who will benefit from cognitive intervention. We evaluated the predictive value of disease-specific biological factors for the outcome after cognitive training in MCI (n = 25) and also considered motivation of the participants. We compared the results of the cognitive intervention group with two independent control groups of MCI patients (local memory clinic, n = 20; ADNI cohort, n = 302)...
November 16, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29141513/alternative-scapular-stabilization-exercises-to-target-strength-endurance-and-function-of-shoulders-in-tetraplegia-a-prospective-non-controlled-intervention-study
#16
Carolina Lins, Alex Castro, Giovanna I S Medina, Eliza R F B M Azevedo, Bruno S Donato, Marina S S Chagas, Janaína Roland Tancredo, Letícia Vargas de Almeida, Alberto Cliquet
OBJECTIVE: Scapular stabilization exercises (SSE) are well-established for the able-bodies. The aim of the current study is to access the potential benefits of SSE on isometric internal and external rotator strength, endurance and function of the shoulder in persons with tetraplegia, throughout a 12-week exercise program consisting of five resisted movements with elastic bands. DESIGN: Prospective non-controlled intervention study. Setting/Participants/Interventions: A convenience sample of 17 subjects (age, 40...
November 16, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29121669/application-and-interpretation-of-functional-data-analysis-techniques-to-differential-scanning-calorimetry-data-from-lupus-patients
#17
Sarah K Kendrick, Qi Zheng, Nichola C Garbett, Guy N Brock
BACKGROUND: DSC is used to determine thermally-induced conformational changes of biomolecules within a blood plasma sample. Recent research has indicated that DSC curves (or thermograms) may have different characteristics based on disease status and, thus, may be useful as a monitoring and diagnostic tool for some diseases. Since thermograms are curves measured over a range of temperature values, they are considered functional data. In this paper we apply functional data analysis techniques to analyze differential scanning calorimetry (DSC) data from individuals from the Lupus Family Registry and Repository (LFRR)...
2017: PloS One
https://www.readbyqxmd.com/read/29114533/effects-of-whole-body-vibration-training-and-mental-training-on-mobility-neuromuscular-performance-and-muscle-strength-in-older-men
#18
Maryam Goudarzian, Samira Ghavi, Ardalan Shariat, Hossein Shirvani, Mostafa Rahimi
This study was designed to evaluate the effects of whole body vibration (WBV) exercise, mental training (MT), and the concurrent effect of WBV and MT on lower body balance, neuromuscular performance, and leg muscle strength in elderly men. In a randomized control trial study with parallel group design, 42 older men (mean±standard deviation age, 68±5.78 years) were randomly divided into four groups: WBV (n=11), MT (n=12), WBV+MT (n=10), and control (n=9) groups. The protocol of training consisted of three sessions per week for 8 weeks and about 30 min for each session...
October 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29114527/effects-of-special-exercise-programs-on-functional-movement-screen-scores-and-injury-prevention-in-preprofessional-young-football-players
#19
Engin Dinc, Bekir Eray Kilinc, Muge Bulat, Yunus Turgay Erten, Bülent Bayraktar
To increase movement capacity and to reduce injury risk in young soccer players by implementing a special functional exercise program based on functional movement screen (FMS) and correctives. 67 young male athletes 14-19 years of age from a Super League Football Club Academy participated in the study. Functional movement patterns were evaluated with FMS assessment protocol. Deep squat, hurdle step, inline lunge, shoulder mobility, active straight leg raise, trunk stability push-up, and rotatory stability were examined in FMS...
October 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29111631/physical-performance-characteristics-between-male-and-female-youth-surfing-athletes
#20
Bruno A Ferreira da Silva, Filipe M Clemente
BACKGRAUND: Despite some knowledge about the fitness levels of elite surfers, there is limited published research examining gender differences, particularly in young athletes. The purpose of this study was to describe and compare the sex differences in physical performance characteristics of elite youth surfers. It was also aimed to study the association between physical performance variables. METHODS: This longitudinal prospective study was based on a total of twenty male and female youth surfers performed a battery of physical performance tests: anthropometrics, weight-bearing dorsiflexion test, Functional Movement Screen, lower extremity dynamic stability, lower limb dynamic strength, paddling and apnea test...
November 7, 2017: Journal of Sports Medicine and Physical Fitness
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