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Predictors medication use anti-depressants

Manit Srisurapanont, Yee Ming Mok, Yen Kuang Yang, Herng-Nieng Chan, Constantine D Della, Nor Zuraida Zainal, Stephen Jambunathan, Nurmiati Amir, Pranab Kalita
BACKGROUND: Several studies have described the presence of perceived cognitive dysfunction amongst Asian patients with major depressive disorder (MDD). To date, no study has been conducted investigating the predictors of perceived cognitive dysfunction amongst Asian MDD patients. METHODS: This was a post-hoc analysis of the Cognitive Dysfunction in Asian patients with Depression (CogDAD) study. Descriptive statistics were used to describe the most common cognitive complaints by patients...
February 16, 2018: Journal of Affective Disorders
Elaine Setiawan, Sophia Attwells, Alan A Wilson, Romina Mizrahi, Pablo M Rusjan, Laura Miler, Cynthia Xu, Sarita Sharma, Stephen Kish, Sylvain Houle, Jeffrey H Meyer
BACKGROUND: People with major depressive disorder frequently exhibit increasing persistence of major depressive episodes. However, evidence for neuroprogression (ie, increasing brain pathology with longer duration of illness) is scarce. Microglial activation, which is an important component of neuroinflammation, is implicated in neuroprogression. We examined the relationship of translocator protein (TSPO) total distribution volume (VT ), a marker of microglial activation, with duration of untreated major depressive disorder, and with total illness duration and antidepressant exposure...
February 26, 2018: Lancet Psychiatry
Carolyn P Da Silva, Bianca Zuckerman, Rhoda Olkin
The purpose of this study was to determine if falls in polio survivors, with or without post-polio syndrome (PPS), are related to number of medications taken, use of anti-depressant or psychoactive medications, or self-report of depression. A survey was sent to 300 members of a regional polio support group, asking them to document their fall history, medications used, and the presence of depression. Depression was measured by self-report and with the Geriatric Depression Scale, short form (GDS-15). One hundred and seventy-two usable surveys were returned with 146 of those completing the medication list...
May 2017: Physiotherapy Theory and Practice
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
Sigal Zilcha-Mano, Steven P Roose, Patrick J Brown, Bret R Rutherford
OBJECTIVES: The high percentage of failed clinical trials for anti-depressant medications, especially in elderly populations, obscures the fact that some patients may benefit greatly from treatment. Early detection of patients who may benefit most from antidepressant medication may improve treatment decisions. We examined whether depressed patients in a large clinical trial exhibit distinct trajectories of early symptom change that predict differential response to medication or placebo...
June 2017: American Journal of Geriatric Psychiatry
Shanti M Pinto, Maria F Twichell, Luke C Henry
BACKGROUND: Although recovery after concussion is spontaneous and typically occurs within 2-3 weeks, a subset of adolescents develop persistent symptoms after a sports-related concussion. Medications are frequently prescribed as part of a comprehensive treatment approach to alleviate these symptoms; however, there are no guidelines for prescription of pharmacologic therapy after concussion. OBJECTIVE: To investigate common factors that are associated with the use of medications (antiepileptic, antidepressant, neurostimulant, or sleeping medication) during recovery from a sports-related concussion...
January 14, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
Alexandra S Creighton, Tanya E Davison, David W Kissane
OBJECTIVE: To synthesize and summarize the studies examining the correlates and predictors of anxiety in older adults living in residential aged care. METHODS: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, five electronic databases were searched using key terms and subject headings, as well as reference lists of relevant papers. The search was limited to peer-reviewed literature published in English. Eligible studies examined the association between at least one correlate/factor and anxiety disorders or symptoms in aged care residents aged 50+ years...
February 2017: International Journal of Geriatric Psychiatry
Robert Howard, Sergi G Costafreda, Keith Karcher, Danielle Coppola, Jesse A Berlin, David Hough
BACKGROUND: Use of antipsychotics to treat behavioural symptoms of dementia has been associated with increased risks of mortality and stroke. Little is known about individual patient characteristics that might be associated with bad or good outcomes. AIMS: We examined the risperidone clinical trial data to look for individual patient characteristics associated with these adverse outcomes. METHOD: Data from all double-blind randomised controlled trials of risperidone in dementia patients (risperidone n = 1009, placebo n = 712) were included...
November 2016: British Journal of Psychiatry: the Journal of Mental Science
Karakula-Juchnowicz Hanna, Kowal-Popczak Agnieszka, Dzikowski Michal, Juchnowicz Dariusz, Dzikowska Izabela, Makarewicz Agata, Dubas-Slemp Halina
OBJECTIVE: To analyse cases of 9 patients (18-27 yo) who were consequently admitted to our department and treated with affective disorders (AD) while undergoing isotretinoin (INN) therapy. METHODS: A semi-structured questionnaire designed by the authors was used to analyse many variables related to demographic characteristics, dermatologic and psychiatrics symptoms, AD course and treatment, family history of mental disorders, building on medical histories of patients and their families, and available medical records...
November 1, 2016: Journal of Affective Disorders
Christopher A Fama, Nita Chen, Julia Prusik, Vignessh Kumar, Meghan Wilock, Steven Roth, Julie G Pilitsis
BACKGROUND: Pre-operative psychological assessment is commonly used to assess patients for spinal cord stimulation (SCS). Though often times mandated by insurance, its value is frequently questioned. METHODS: We review the literature on the predictive value of psychological testing prior to SCS and retrospectively examine our prospective database of SCS patients. We examine associations of Minnesota Multiphasic Personality Inventory (MMPI), Beck Depression Inventory (BDI), and Pain Catastrophizing Scale (PCS) findings and outcomes on the visual analog scale (VAS), McGill Pain Questionnaire - Short Form (MPQ), and Oswestry Disability Index (ODI) at 6 and 12 months post-implantation...
June 2016: Neuromodulation: Journal of the International Neuromodulation Society
Akihiro Ohishi, Yugo Chisaki, Daiki Hira, Kazuki Nagasawa, Tomohiro Terada
BACKGROUND: Pregabalin, a gabapentinoid, is an adjuvant analgesic for treatment of neuropathic pain, but it has serious adverse effects such as somnolence and dizziness, particularly in elderly patients. Although decreased renal function is considered to the contributing factor for high frequency of these adverse effects in elder patients, only a few systematic clinical investigations, especially for hospitalized patients, have been performed on factors that might affect the incidence of its adverse effects...
2015: Journal of Pharmaceutical Health Care and Sciences
David Price, Andrew M Wilson, Alison Chisholm, Anna Rigazio, Anne Burden, Michael Thomas, Christine King
PURPOSE: Acute, severe asthma exacerbations can be difficult to predict and thus prevent. Patients who have frequent exacerbations are of particular concern. Practical exacerbation predictors are needed for these patients in the primary-care setting. PATIENTS AND METHODS: Medical records of 130,547 asthma patients aged 12-80 years from the UK Optimum Patient Care Research Database and Clinical Practice Research Datalink, 1990-2013, were examined for 1 year before (baseline) and 1 year after (outcome) their most recent blood eosinophil count...
2016: Journal of Asthma and Allergy
Weng-Ming Liu, Ru-Jen Lin, Rwei-Ling Yu, Chun-Hwei Tai, Chin-Hsien Lin, Ruey-Meei Wu
PURPOSE: The nonmotor symptoms (NMS) of Parkinson's disease (PD) are important factors for quality of life (QoL). Few studies on NMS have been conducted in Asian PD patients. Additionally, effects of anti-PD drugs on risk of NMS are still controversial. We therefore conducted this hospital-based cross-sectional study to examine the clinical factors, including concomitant anti-PD medication use, on the occurrence of NMS and QoL in Taiwanese PD patients. PATIENTS AND METHODS: PD patients who received long-term follow-up in the movement disorders clinics were enrolled and received NMS questionnaire (NMSQuest) and the 39-item Parkinson's Disease Questionnaire (PDQ-39)...
2015: Neuropsychiatric Disease and Treatment
Annelieke Pasma, Charlotte V Schenk, Reinier Timman, Jan J V Busschbach, Bart J F van den Bemt, Esmeralda Molenaar, Willemijn H van der Laan, Saskia Schrauwen, Adriaan Van't Spijker, Johanna M W Hazes
INTRODUCTION: Non-adherence to disease-modifying antirheumatic drugs (DMARDs) hampers the targets of rheumatoid arthritis (RA) treatment, obtaining low disease activity and decreasing radiological progression. This study investigates if, and to what extent, non-adherence to treatment would lead to a higher 28-joint count disease activity score (DAS28) in the first year after diagnosis. METHODS: Adult patients from an ongoing cohort study on treatment adherence were selected if they fulfilled the EULAR/ACR2010 criteria for RA, and were to start with their first DMARDs...
October 8, 2015: Arthritis Research & Therapy
Kee F Chi, Mayuresh Korgaonkar, Stuart M Grieve
BACKGROUND: We review what is currently known about neuroimaging predictors of remission in major depressive disorder (MDD) after antidepressant medication (ADM) treatment. METHODS: A systematic literature search found a total of twenty-seven studies comparing baseline neuroimaging findings in depressed patients who achieved remission with non-remitters following treatment with ADMs. RESULTS: Eighteen of these studies utilised structural magnetic resonance imaging (MRI)...
November 1, 2015: Journal of Affective Disorders
Mark A Babizhayev, Yegor E Yegorov
BACKGROUND: Visual impairment broadly impacts the ability of affected people to maintain their function and to remain independent during their daily occupations as they grow older. Visual impairment affects survival of older patients, quality of life, can affect a person's self-ranking of health, may be associated with social and functional decline, use of community support services, depression, falls, nursing home placement, and increased mortality. It has been hypothesized that senile cataract may serve as a marker for generalised tissue aging, since structural changes occurring in the proteins of the lens during cataract formation are similar to those which occur elsewhere as part of the aging process...
2016: Recent Patents on Drug Delivery & Formulation
Hajar Hamza, Hend El-Taweel, Sahar Abou-Holw, Safia Khalil, Eman Wagdy
Infection is a significant cause of morbidity and mortality in patients with chronic kidney disease (CKD) due to their depressed immunity. T. gondii is a ubiquitous parasite that causes severe manifestations in immunocomprmised patients. The present study investigated rate, pattern, predictors and related morbidity of T. gondii seropositivity in CKD patients. The study included four groups: i- patients on maintenance hemodialysis (HD; n = 60); ii- patients with systemic lupus erythematosus on immunosuppressive therapy for lupus nephritis (SLE; n = 30) iii-Renal transplant recipients (RTR; n = 30) and iv- healthy controls (HC; n = 30)...
April 2015: Journal of the Egyptian Society of Parasitology
Kieron B L Lim, Hamid R Sima, M Isabel Fiel, Viktoriya Khaitova, John T Doucette, Maria Chernyiak, Jawad Ahmad, Nancy Bach, Charissa Chang, Priya Grewal, Leona Kim-Schluger, Lawrence Liu, Joseph Odin, Ponni Perumalswami, Sander S Florman, Thomas D Schiano
AIM: To describe our experience using a low-accelerating-dose regimen (LADR) with pegylated interferon alpha-2a and ribavirin in treatment of hepatitis C virus (HCV) recurrence. METHODS: From 2003, a protocolized LADR strategy was employed to treat liver transplant (LT) recipients with recurrent HCV at our institution. Medical records of 182 adult patients with recurrent HCV treated with LADR between 1/2003 and 1/2011 were reviewed. Histopathology from all post-LT liver biopsies were reviewed in a blinded fashion...
May 28, 2015: World Journal of Gastroenterology: WJG
Roxanne Cooksey, Sinead Brophy, Michael Dennis, Helen Davies, Mark Atkinson, Elizabeth Irvine, Stefan Siebert
OBJECTIVE: To explore severe flare and constant disease pattern (no periods of remission) in AS as predictors of poor outcomes [impaired function, unemployment/early retirement, work impairment, anti-TNF, surgery, frequent general practitioner (GP) visits, depression and anxiety]. METHODS: Three hundred and forty-eight AS patients completed questionnaires about their experience with disease flares. Questionnaire data were linked to electronic medical records to examine visits to GPs and hospital admission data...
September 2015: Rheumatology
Jemily Malvar, Florin Vaida, Chelsea Fitzsimons Sanders, J Hampton Atkinson, William Bohannon, John Keltner, Jessica Robinson-Papp, David M Simpson, Christina M Marra, David B Clifford, Benjamin Gelman, Juanjuan Fan, Igor Grant, Ronald J Ellis
Despite modern combination antiretroviral therapy, distal neuropathic pain (DNP) continues to affect many individuals with HIV infection. We evaluated risk factors for new-onset DNP in the CNS Antiretroviral Therapy Effects Research (CHARTER) study, an observational cohort. Standardized, semiannual clinical evaluations were administered at 6 US sites. Distal neuropathic pain was defined by using a clinician-administered instrument standardized across sites. All participants analyzed were free of DNP at study entry...
April 2015: Pain
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