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https://www.readbyqxmd.com/read/28734272/glycosylation-patterns-of-selected-proteins-in-individual-serum-and-cerebrospinal-fluid-samples
#1
Isabella Karlsson, Lorena Ndreu, Alessandro Quaranta, Gunnar Thorsén
A method we previously developed has been applied to the determination of the glycosylation pattern of specific proteins in biological samples. Six proteins (alpha-1-antitrypsin, transferrin, haptoglobin, C1 inhibitor, alpha-1 acid glycoprotein, and immunoglobulin G) were studied in serum samples from five individuals and cerebrospinal fluid (CSF) samples from three individuals, to investigate the expected normal distribution of glycosylation patterns and to assess whether this methodology can be used to discriminate between samples from different individuals...
April 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28734266/air-quality-and-health-effects-of-biogenic-volatile-organic-compounds-emissions-from-urban-green-spaces-and-the-mitigation-strategies
#2
Yuan Ren, Zelong Qu, Yuanyuan Du, Ronghua Xu, Danping Ma, Guofu Yang, Yan Shi, Xing Fan, Akira Tani, Peipei Guo, Ying Ge, Jie Chang
Biogenic volatile organic compounds (BVOCs) emissions lead to fine particulate matter (PM2.5) and ground-level ozone pollution, and are harmful to human health, especially in urban areas. However, most BVOCs estimations ignored the emissions from urban green spaces, causing inaccuracies in the understanding of regional BVOCs emissions and their environmental and health effects. In this study, we used the latest local vegetation datasets from our field survey and applied an estimation model to analyze the spatial-temporal patterns, air quality impacts, health damage and mitigating strategies of BVOCs emissions in the Greater Beijing Area...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734247/seasonal-variation-in-water-uptake-patterns-of-three-plant-species-based-on-stable-isotopes-in-the-semi-arid-loess-plateau
#3
Jian Wang, Bojie Fu, Nan Lu, Li Zhang
Water is a limiting factor and significant driving force for ecosystem processes in arid and semi-arid areas. Knowledge of plant water uptake pattern is indispensable for understanding soil-plant interactions and species coexistence. The 'Grain for Green' project that started in 1999 in the Loess Plateau of China has led to large scale vegetation change. However, little is known about the water uptake patterns of the main plant species that inhabit in this region. In this study, the seasonal variations in water uptake patterns of three representative plant species, Stipa bungeana, Artemisia gmelinii and Vitex negundo, that are widely distributed in the semi-arid area of the Loess Plateau, were identified by using dual stable isotopes of δ(2)H and δ(18)O in plant and soil water coupled with a Bayesian mixing model MixSIAR...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734246/topological-pattern-for-the-search-of-new-active-drugs-against-methicillin-resistant-staphylococcus-aureus
#4
Jose I Bueso-Bordils, Maria T Perez-Gracia, Beatriz Suay-Garcia, Maria J Duart, Rafael V Martin Algarra, Luis Lahuerta Zamora, Gerardo M Anton-Fos, Pedro A Aleman Lopez
Molecular topology was used to develop a mathematical model capable of classifying compounds according to antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). Topological indices were used as structural descriptors and their relation to antimicrobial activity was determined by using linear discriminant analysis. This topological model establishes new structure activity relationships which show that the presence of cyclopropyl, chlorine and ramification pairs at a distance of two bonds favor this activity, while the presence of tertiary amines decreases it...
July 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28734242/environmental-estrogen-s-induced-swimming-behavioural-alterations-in-adult-zebrafish-danio-rerio
#5
Basavaraj B Goundadkar, Pancharatna Katti
The present study is an attempt to investigate the effects of long-term (75days) exposure to environmental estrogens (EE) on the swimming behaviour of zebrafish (Danio rerio). Adult zebrafish were exposed semi-statically to media containing commonly detected estrogenic water contaminants (EE2, DES and BPA) at a concentration (5ng/L) much lower than environmentally recorded levels. Time spent in swimming, surface preference, patterns and path of swimming were recorded (6mins) for each fish using two video cameras on day 15, 30 60 and 75...
July 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28734205/identification-of-mycobacterium-tuberculosis-enoyl-acyl-carrier-protein-reductase-inhibitors-a-combined-in-silico-and-in-vitro-analysis
#6
Mohsin Y Lone, Mohd Athar, Vivek K Gupta, Prakash C Jha
Mycobacterium tuberculosis (Mtb), had developed evolutionary changes in its genome to adapt for survival and thereby generated multi-drug resistant strains. However, novel drug targets that remained unchanged for their biochemical role has impressed the research community to target such proteins. The comprehensive analysis of multiple protein targets has influenced us to make a consensus structural rule exploited by pharmacophore and other allied techniques from a large repository of protein structures. In this pursuit, we made a retrospective analysis of pharmacophores mapped from the tuberculosis structural proteome and identified unique patterns that can be employed for the novel molecules design...
July 14, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28734192/trajectories-of-risk-behaviors-across-adolescence-and-young-adulthood-the-role-of-race-and-ethnicity
#7
Eunhee Park, Thomas P McCoy, Jennifer Toller Erausquin, Robin Bartlett
INTRODUCTION: Despite important advances of longitudinal research in substance use behaviors, most studies stratify analyses by gender or race, which limits the ability to directly compare the likelihood of a particular developmental pathway across demographic groups. Thus, there is critical need for well-designed research to examine the associations of race/ethnicity with developmental trajectories of substance use behaviors across adolescence through adulthood. METHODS: Using an accelerated longitudinal design, we examined behaviors across ages 12-31 from Waves I-IV of the National Longitudinal Study of Adolescent to Adult Health...
July 15, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734174/old-and-new-adjuvants
#8
REVIEW
Amy S McKee, Philippa Marrack
Adjuvants have been deliberately added to vaccines since the 1920's when alum was discovered to boost antibody responses, leading to better protection. The first adjuvants were discovered by accident and were used in the safer but less immunogenic subunit vaccines, supposedly by providing an antigen depot to extend antigen presentation. Since that time, much has been discovered about how these adjuvants impact cells at the tissue site to activate innate immune responses, mobilize dendritic cells and drive adaptive immunity...
July 19, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28734171/muscle-synergies-reveal-impaired-trunk-muscle-coordination-strategies-in-individuals-with-thoracic-spinal-cord-injury
#9
Matija Milosevic, Hikaru Yokoyama, Murielle Grangeon, Kei Masani, Milos R Popovic, Kimitaka Nakazawa, Dany H Gagnon
Spinal cord injury (SCI) can result in paralysis of trunk muscles, which can affect sitting balance. The objective of this study was to analyze trunk muscle coordination of individuals with thoracic SCI and compare it to able-body individuals. A total of 27 individuals were recruited and subdivided into: (a) high thoracic SCI; (b) low thoracic SCI; and (c) able-body groups. Participants were seated and asked to lean their trunk in eight directions while trunk muscle activity was recorded. Muscle coordination was assessed using the non-negative matrix factorization (NMF) method to extract muscle modules, which are the synergistic trunk muscle activations, and their directional activation patterns...
July 1, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28734161/evaluation-of-the-effect-of-extraction-solvent-and-organ-selection-on-the-chemical-profile-of-astragalus-spinosus-using-hptlc-multivariate-image-analysis
#10
Eman Shawky, Dina A Selim
The evaluation of extraction protocols for untargeted and targeted metabolomics was implemented for root and aerial organs of Astragalus spinosus in this work. The efficiency and complementarity of commonly used extraction solvents, namely petroleum ether, methylene chloride, ethyl acetate and n-butanol were considered for method evaluation using chemometric techniques in conjunction with new, simple, and fast high performance thin layer chromatography (HPTLC) method for fingerprint analysis by extracting information from a digitalized HPTLC plate using ImageJ software...
July 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28734152/trajectories-of-alcohol-use-in-the-uk-military-and-associations-with-mental-health
#11
L Goodwin, S Norton, N T Fear, M Jones, L Hull, S Wessely, R J Rona
INTRODUCTION: There are higher levels of alcohol misuse in the military compared to the general population. Yet there is a dearth of research in military populations on the longitudinal patterns of alcohol use. This study aims to identify group trajectories of alcohol consumption in the UK military and to identify associations with childhood adversity, deployment history and mental disorder. METHODS: Data on weekly alcohol consumption across an eight year period and three phases of a UK military cohort study (n=667) were examined using growth mixture modelling...
July 12, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734144/expression-of-planar-cell-polarity-genes-during-mouse-tooth-development
#12
Nobuko Obara, Yuko Suzuki, Kazuharu Irie, Shunichi Shibata
OBJECTIVE: Planar cell polarity (PCP) refers to the cell polarity across the tissue plane and controls various cell behaviors and structures. Although the expression of several PCP signaling components has been detected in tooth germs, knowledge of the gene expression patterns of these PCP components during tooth development remains incomplete. The aim of this study is to characterize the temporal and spatial changes in PCP gene expression during tooth development. DESIGN: Expression of Celsr1 and 2, Fzd3 and 6, Vangl1 and 2, and Dvl1-3 genes was analyzed in mouse molar germs from the bud to the bell stage using in situ hybridization...
July 14, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28734137/precision-targeting-by-phosphoinositides-how-pis-direct-endomembrane-trafficking-in-plants
#13
REVIEW
Lise C Noack, Yvon Jaillais
Each phosphoinositide (PI, also known as phosphatidylinositol phosphate, polyphosphoinositide, PtdInsP or PIP) species is partitioned in the endomembrane system and thereby contributes to the identity of membrane compartments. However, membranes are in constant flux within this system, which raises the questions of how the spatiotemporal pattern of phosphoinositides is established and maintained within the cell. Here, we review the general mechanisms by which phosphoinositides and membrane trafficking feedbacks on each other to regulate cellular patterning...
July 19, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28734132/high-dimensional-single-cell-mapping-of-cerium-distribution-in-the-lung-immune-microenvironment-of-an-active-smoker
#14
Adeeb H Rahman, Yonit Lavin, Soma Kobayashi, Andrew Leader, Miriam Merad
BACKGROUND: Mass cytometry leverages inductively coupled mass spectrometry to perform high dimensional single cell analyses using antibodies tagged with rare earth isotopes that are considered to be largely absent in biological samples. We have recently noted an unusual exception to this rule while analyzing tissue samples from patients undergoing surgical resection for early stage lung cancer, and here we present a detailed cytometric characterization of cerium in a clinical patient sample...
July 22, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28734121/the-impact-of-chronic-psychiatric-disorders-on-cognitive-decline
#15
R Villeneuve, C Blanchard, L Rullier, N Raoux, V Bergua, J-F Dartigues, K Pérès, H Amieva
OBJECTIVES: Based on seemingly contradictory results in the existing literature, the objective of our study was to investigate whether older individuals suffering from chronic psychiatric disorders show a more rapid decline in cognitive performances than their non-psychiatric counterparts, or if the pattern of decline through older age is similar in both groups. METHOD: A total of 820 older adults were selected from the Ageing Multidisciplinary Investigation (AMI) cohort study, which studies health-related issues of people over 65 years old living in rural areas...
July 22, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28732342/scope-mtl-a-non-invasive-tool-for-identifying-and-lateralizing-mesial-temporal-lobe-seizures-prior-to-scalp-eeg-ictal-onset
#16
Alice D Lam, Douglas Maus, Sahar F Zafar, Andrew J Cole, Sydney S Cash
OBJECTIVE: In mesial temporal lobe (mTL) epilepsy, seizure onset can precede the appearance of a scalp EEG ictal pattern by many seconds. The ability to identify this early, occult mTL seizure activity could improve lateralization and localization of mTL seizures on scalp EEG. METHODS: Using scalp EEG spectral features and machine learning approaches on a dataset of combined scalp EEG and foramen ovale electrode recordings in patients with mTL epilepsy, we developed an algorithm, SCOPE-mTL, to detect and lateralize early, occult mTL seizure activity, prior to the appearance of a scalp EEG ictal pattern...
July 1, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28732318/the-experimental-tobacco-marketplace-ii-substitutability-and-sex-effects-in-dual-electronic-cigarette-and-conventional-cigarette-users
#17
Amanda J Quisenberry, Mikhail N Koffarnus, Leonard H Epstein, Warren K Bickel
AIM: The aim of the current study was to evaluate tobacco product purchasing in the Experimental: Tobacco Marketplace (ETM) among male and female smokers who also use e-cigarettes. We hypothesized a high substitution profile for e-cigarettes and that males would purchase more Snus than females. METHODS: The ETM is an online market used in clinical abuse liability research to mimic real-world purchasing patterns. Tobacco products, including each participant's usual choice of conventional and e-cigarettes, were presented along with a price and description of nicotine content...
July 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28732273/using-computational-theory-to-constrain-statistical-models-of-neural-data
#18
REVIEW
Scott W Linderman, Samuel J Gershman
Computational neuroscience is, to first order, dominated by two approaches: the 'bottom-up' approach, which searches for statistical patterns in large-scale neural recordings, and the 'top-down' approach, which begins with a theory of computation and considers plausible neural implementations. While this division is not clear-cut, we argue that these approaches should be much more intimately linked. From a Bayesian perspective, computational theories provide constrained prior distributions on neural data-albeit highly sophisticated ones...
July 18, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28732269/gyral-net-a-new-representation-of-cortical-folding-organization
#19
Hanbo Chen, Yujie Li, Fangfei Ge, Gang Li, Dinggang Shen, Tianming Liu
One distinct feature of the cerebral cortex is its convex (gyri) and concave (sulci) folding patterns. Due to the remarkable complexity and variability of gyral/sulcal shapes, it has been challenging to quantitatively model their organization patterns. Inspired by the observation that the lines of gyral crests can form a connected graph on each brain hemisphere, we propose a new representation of cortical gyri/sulci organization pattern - gyral net, which models cortical architecture from a graph perspective, starting with nodes and edges obtained from the reconstructed cortical surfaces...
July 15, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28732229/a-novel-approach-to-fabricate-dye-encapsulated-polymeric-micro-and-nanoparticles-by-thin-film-dewetting-technique
#20
Manosree Chatterjee, Abhiram Hens, Kuldeep Mahato, Namita Jaiswal, Nivedita Mahato, Nagahanumaiah, Nripen Chanda
A new method is reported for fabrication of polymeric micro- and nanoparticles from an intermediate patterned surface originated by dewetting of a polymeric thin film. Poly (d, l-lactide-co-glycolide) or PLGA, a biocompatible polymer is used to develop a thin film over a clean glass substrate which dewets spontaneously in the micro-/nano-patterned surface of size range 50nm to 3.5µm. Since another water-soluble polymer, poly vinyl alcohol (PVA) is coated on the same glass substrate before PLGA thin film formation, developed micro-/nano-patterns are easily extracted in water in the form of micro- and nanoparticle mixture of size range 50nm to 3...
July 8, 2017: Journal of Colloid and Interface Science
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