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https://www.readbyqxmd.com/read/29323634/epidemiology-of-traumatic-spinal-cord-injury-in-tianjin-china-an-18-year-retrospective-study-of-735-cases
#1
Hai-Liang Li, Hong Xu, Yu-Lin Li, Shi-Wei Sun, Wen-Ye Song, Qiang Wu, Jie Ai, Jing-Cheng Sun, Guang-Zhi Ning, Shi-Qing Feng
STUDY DESIGN: Hospital-based retrospective study Objectives: To evaluate the pathogenetic features of traumatic spinal cord injury (TSCI) during 1999-2016 according to changed injury etiology with time, explore different characteristics of patients suffered a TSCI during 1999-2007 and 2008-2016 in Tianjin, China. SETTING: Tianjin Medical University General Hospital Methods: In this study, the medical records of TSCI patients were obtained from Tianjin Medical University General Hospital (TMUGH) from 1st January 1999 to 31th December 2016...
January 11, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29289419/early-surgical-decompression-within-8-hours-for-traumatic-spinal-cord-injury-is-it-beneficial-a-meta-analysis
#2
Dong-Yeong Lee, Young-Jin Park, Hyun-Jung Kim, Hyeong-Sik Ahn, Sun-Chul Hwang, Dong-Hee Kim
INTRODUCTION: The aim of this study is to evaluate whether early (<8 h) surgical decompression is better in improving neurologic outcomes than late (≥8 h) surgical decompression for traumatic spinal cord injury (tSCI). METHODS: The various electronic databases were used to detect relevant articles published up until May 2016 that compared the outcomes of early versus late surgery for tSCI. Data searching, extraction, analysis, and quality assessment were performed according to Cochrane Collaboration guidelines...
December 27, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29285620/effect-of-the-combined-treatment-of-albumin-with-plasma-synthesised-pyrrole-polymers-on-motor-recovery-after-traumatic-spinal-cord-injury-in-rats
#3
Omar Fabela-Sánchez, Hermelinda Salgado-Ceballos, Luis Medina-Torres, Laura Álvarez-Mejía, Stephany Sánchez-Torres, Rodrigo Mondragón-Lozano, Axayácatl Morales-Guadarrama, Araceli Díaz-Ruiz, María-Guadalupe Olayo, Guillermo J Cruz, Juan Morales, Camilo Ríos, Roberto Olayo
Traumatic spinal cord injury (TSCI) is a health problem for which there is currently no treatment or definitive therapy. Medicine has explored therapeutic options for patients with TSCI with the aim to improve their quality of life. One alternative has been the development of biomaterials that offer neuroprotection or neuroregeneration of damaged nerve tissue. The microinjection of iodine-doped polypyrrole particles synthesised by plasma (PPPy/I) has shown neuroprotective effects that favour motor function recovery in experimental animals with TSCI...
December 28, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29184200/altered-cerebellar-connectivity-in-autism-and-cerebellar-mediated-rescue-of-autism-related-behaviors-in-mice
#4
Catherine J Stoodley, Anila M D'Mello, Jacob Ellegood, Vikram Jakkamsetti, Pei Liu, Mary Beth Nebel, Jennifer M Gibson, Elyza Kelly, Fantao Meng, Christopher A Cano, Juan M Pascual, Stewart H Mostofsky, Jason P Lerch, Peter T Tsai
Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans resulted in altered functional connectivity with the inferior parietal lobule, and children with ASD showed atypical functional connectivity in this circuit. Atypical RCrusI-inferior parietal lobule structural connectivity was also evident in the Purkinje neuron (PN) TscI ASD mouse model...
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29152109/sevoflurane-preconditioning-ameliorates-traumatic-spinal-cord-injury-through-caveolin-3-dependent-cyclooxygenase-2-inhibition
#5
Weidong Wu, Ningxian Wei, Lihui Wang, Danhui Kong, Gang Shao, Yingchun Qin, Lixin Wang, Yansheng Du
Acute traumatic spinal cord injury (tSCI) results in a lifetime of paralysis associated with a host of medical complications. The developing secondary complications of tSCI may result in further chronic neurodegenerative diseases. Sevoflurane preconditioning (SF-PreCon) has shown guaranteed protective effects in myocardial or cerebral ischemic/reperfusion injury. However, the role of SF-PreCon in tSCI still remains to be elucidated. Here, we found that SF-PreCon ameliorated the developing secondary complications through reducing the apoptosis rate and the secretion of inflammatory cytokines in injured spinal cord tissues, and therefore enhancing the recovery after tSCI...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133968/effects-of-laser-therapy-and-grimaldi-s-muscle-shortening-manoeuvre-on-motor-control-of-subjects-with-incomplete-spinal-cord-injuries
#6
Diego Longo, Leonardo Longo, Paolo Lippi, Giulio Cherubini, Vanessa Mangé
Background and Objectives: From year 2003 we treated positively 251 patients with Traumatic Spinal Cord Injuries (TSCI), using Non-Surgical Laser Therapy (NSLT). In order to increase muscle strength, we have also started using a physical therapy practice called Grimaldi's Muscle Shortening Manoeuvre (GMSM)The goal of our study is to obtain objective data suggesting the real effectiveness of the association of these two treatments. Study Design and Methods: In 2015, 10 patients with incomplete TSCI were enrolled...
September 30, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29105658/representativeness-of-the-spinal-cord-injury-model-systems-national-database
#7
Jessica M Ketchum, Jeffrey P Cuthbert, Anne Deutsch, Yuying Chen, Susan Charlifue, David Chen, Marcel P Dijkers, James E Graham, Allen W Heinemann, Daniel P Lammertse, Gale G Whiteneck
STUDY DESIGN: Secondary analysis of prospectively collected observational data. OBJECTIVES: To assess the representativeness of the Spinal Cord Injury Model Systems National Database (SCIMS-NDB) of all adults aged 18 years or older receiving inpatient rehabilitation in the United States (US) for new onset traumatic spinal cord injury (TSCI). SETTING: Inpatient rehabilitation centers in the US. METHODS: We compared demographic, functional status, and injury characteristics (nine categorical variables comprising of 46 categories and two continuous variables) between the SCIMS-NDB (N = 5969) and UDS-PRO/eRehabData (N = 99,142) cases discharged from inpatient rehabilitation in 2000-2010...
November 6, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28948966/suicide-and-traumatic-spinal-cord-injury-a-cohort-study
#8
G Savic, M J DeVivo, H L Frankel, M A Jamous, B M Soni, S Charlifue
STUDY DESIGN: Retrospective and prospective observational. OBJECTIVE: The main objective of this study was to analyse suicide attempt as a cause of traumatic spinal cord injury (tSCI) and suicide as a cause of death after tSCI. SETTING: This study was conducted at two British spinal centres, Stoke Mandeville and Southport. METHODS: Long-term survival of patients who were newly admitted between 1991 and 2010, had survived the first post-injury year and had neurological deficit on discharge...
September 26, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28872148/incidence-of-traumatic-spinal-cord-injury-in-italy-during-2013-2014-a-population-based-study
#9
S Ferro, L Cecconi, J Bonavita, M C Pagliacci, A Biggeri, M Franceschini
STUDY DESIGN: Observational prospective population-based incidence study. OBJECTIVES: The main objective of this study was to assess the incidence of traumatic spinal cord injuries (TSCIs) and incidence rates, in order to provide estimates by age, gender, characteristics and cause. SETTING: This study was conducted at acute-care spinal cord injury (SCI) hospitals and SCI centers from 11 Italian regions, between 1 October 2013 and 30 September 2014...
September 5, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28863195/risk-factors-for-14-day-rehospitalization-following-trauma-with-new-traumatic-spinal-cord-injury-diagnosis-a-10-year-nationwide-study-in-taiwan
#10
Carlos Lam, Ping-Ling Chen, Jiunn-Horng Kang, Kuang-Fu Cheng, Ray-Jade Chen, Kuo-Sheng Hung
OBJECTIVES: Fourteen-day rehospitalization with new traumatic spinal cord injury (tSCI) diagnosis is used as an indicator for the diagnostic quality of the first hospitalization. In this nationwide population-based cohort study, we identified risk factors for this indicator. METHODS: We conducted a nested case-control study by using the data of patients who received a first hospitalization for trauma between 2001 and 2011. The data were retrieved from Taiwan's National Health Insurance Research Database...
2017: PloS One
https://www.readbyqxmd.com/read/28758566/the-influence-of-level-of-spinal-cord-injury-on-adipose-tissue-and-its-relationship-to-inflammatory-adipokines-and-cardiometabolic-profiles
#11
Gary J Farkas, Ashraf S Gorgey, David R Dolbow, Arthur S Berg, David R Gater
OBJECTIVE: Level of injury (LOI) and the role of adipose tissue and its proinflammatory adipokines in cardiometabolic dysfunction following spinal cord injury (SCI) remains poorly understood. We aim to examine the influence of LOI on adipose tissue and its relationship to proinflammatory adipokines and cardiometabolic profiles following SCI. DESIGN: Cross sectional and correlational study. SETTING: Clinical hospital and academic setting. PARTICIPANTS: Forty-seven individuals with chronic motor complete SCI (age 43...
July 30, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28745934/spinal-cord-injury-clinical-registries-improving-care-across-the-sci-care-continuum-by-identifying-knowledge-gaps
#12
Marcel F Dvorak, Christiana L Cheng, Nader Fallah, Argelio Santos, Derek Atkins, Suzanne Humphreys, Carly S Rivers, Barry A B White, Chester Ho, Henry Ahn, Brian K Kwon, Sean Christie, Vanessa K Noonan
Timely access and ongoing delivery of care and therapeutic interventions is needed to maximize recovery and function after traumatic spinal cord injury (tSCI). To ensure these decisions are evidence-based, access to consistent, reliable, and valid sources of clinical data is required. The Access to Care and Timing Model used data from the Rick Hansen SCI Registry (RHSCIR) to generate a simulation of healthcare delivery for persons after tSCI and to test scenarios aimed at improving outcomes and reducing the economic burden of SCI...
October 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28711537/increased-risk-of-anxiety-or-depression-after-traumatic-spinal-cord-injury-in-patients-with-preexisting-hyperlipidemia-a-population-based-study
#13
Sher-Wei Lim, Tee-Tau Eric Nyam, Chung-Han Ho, Yow-Ling Shiue, Jhi-Joung Wang, Chung-Ching Chio, Jinn-Rung Kuo
OBJECTIVE: Anxiety or depression (AD) is a common complication after traumatic spinal cord injury (tSCI). This study sought to investigate the role of preexisting hyperlipidemia in new-onset AD after tSCI using a longitudinal population database. METHODS: This retrospective cohort study used Longitudinal Health Insurance Database data from January 1997 to December 2011. The case and comparison groups were individuals who experienced tSCI and who did and did not have preexisting hyperlipidemia, respectively...
October 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28673315/mortality-due-to-traumatic-spinal-cord-injuries-in-europe-a-cross-sectional-and-pooled-analysis-of-population-wide-data-from-22-countries
#14
Marek Majdan, Dominika Plancikova, Eva Nemcovska, Lenka Krajcovicova, Alexandra Brazinova, Martin Rusnak
BACKGROUND: Traumatic spinal cord injuries (TSCI) pose a significant burden globally, while existing epidemiological data-especially on population mortality-are limited. The aim of this study was to calculate the age-standardized population mortality rates attributable to TSCI in 22 European countries, along with the pooled age-standardized mortality rate attributable to TSCI in Europe. METHODS: A descriptive cross-sectional epidemiological study was conducted. Crude and age-standardized mortality rates attributable to TSCI for the year 2012 for 22 European countries were compared using data from death certificates provided by Eurostat...
July 3, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28631749/causes-of-death-after-traumatic-spinal-cord-injury-a-70-year-british-study
#15
G Savic, M J DeVivo, H L Frankel, M A Jamous, B M Soni, S Charlifue
DESIGN: Retrospective and prospective observational. OBJECTIVE: Analyse causes of death after traumatic spinal cord injury (tSCI) in persons surviving the first year post injury, and establish any trend over time. SETTING: Two spinal centres in Great Britain. METHODS: The sample consisted of 5483 patients with tSCI admitted to Stoke Mandeville and Southport spinal centres who were injured between 1943 and 2010, survived first year post injury, had residual neurological deficit on discharge and were British residents...
October 2017: Spinal Cord
https://www.readbyqxmd.com/read/28631748/ccl-2-as-a-possible-early-marker-for-remission-after-traumatic-spinal-cord-injury
#16
R A Heller, T F Raven, T Swing, K Kunzmann, V Daniel, P Haubruck, M Akbar, P A Grützner, G Schmidmaier, B Biglari, A Moghaddam
STUDY DESIGN: Prospective observational study. OBJECTIVES: To describe the correlation between CCL-2, CCL-3, CCL-4 and CXCL-5 serum levels and remission after traumatic spinal cord injury (SCI) in a human protocol compared with animal studies. SETTING: Germany, Rhineland-Palatinate (Rheinland-Pfalz). METHODS: We examined the serum levels of CCL-2, CCL-3, CCL-4 and CXCL-5 over a 12-week period; in particular, at admission and 4, 9 and 12 h, 1 and 3 days and 1, 2, 4, 8 and 12 weeks after trauma...
November 2017: Spinal Cord
https://www.readbyqxmd.com/read/28594315/forecasting-financial-resources-for-future-traumatic-spinal-cord-injury-care-using-simulation-modeling
#17
Henry Ahn, Rachel Lewis, Argelio Santos, Christiana L Cheng, Vanessa K Noonan, Marcel F Dvorak, Anoushka Singh, A Gary Linassi, Sean Christie, Michael Goytan, Derek Atkins
Survivors of traumatic spinal cord injury (tSCI) have intense healthcare needs during acute and rehabilitation care and often through the rest of life. To prepare for a growing and aging population, simulation modeling was used to forecast the change in healthcare financial resources and long-term patient outcomes between 2012 and 2032. The model was developed with data from acute and rehabilitation care facilities across Canada participating in the Access to Care and Timing project. Future population and tSCI incidence for 2012 and 2032 were predicted with data from Statistics Canada and the Canadian Institute for Health Information...
October 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28580635/a-cross-sectional-study-of-the-catheter-management-of-neurogenic-bladder-after-traumatic-spinal-cord-injury
#18
Giulia I Lane, Amy Driscoll, Kyrollos Tawfik, Kristin Chrouser
AIMS: This cross-sectional study describes the catheter management of neurogenic bladder (NGB) in patients with traumatic spinal cord injury (tSCI) with emphasis on the motivations behind transitions between intermittent (IC) and indwelling catheters. METHODS: Patients at the Minneapolis VA with history of tSCI who utilized either intermittent catheterization (IC), urethral (UC) or suprapubic (SP) catheters, participated in a voluntary, anonymous survey regarding their bladder management strategies...
June 5, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28578120/intraspinal-pressure-monitoring-and-extensive-duroplasty-in-the-acute-phase-of-traumatic-spinal-cord-injury-a-systematic-review
#19
REVIEW
Tomasz Tykocki, Łukasz Poniatowski, Marcin Czyż, Michael Koziara, Guy Wynne-Jones
OBJECTIVE: The prognosis in cervical spinal cord injury is poor, and surgical and neurointensive care management need further improvement. Monitoring of the intraspinal pressure (ISP) at an early stage after traumatic spinal cord injury (tSCI) is useful clinically. MATERIALS AND METHODS: Obtaining continuous spinal cord perfusion pressure (SCPP) measurements based on the difference between mean arterial pressure and ISP allows offering best medical and surgical treatment during this critical phase of tSCI...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28566019/using-evidence-to-inform-practice-and-policy-to-enhance-the-quality-of-care-for-persons-with-traumatic-spinal-cord-injury
#20
Michael G Fehlings, Christiana L Cheng, Elaine Chan, Nancy P Thorogood, Vanessa K Noonan, Henry Ahn, Christopher S Bailey, Anoushka Singh, Marcel F Dvorak
In today's economic climate, there is a need to demonstrate a return on investment for healthcare spending and for clinical practice and policy to be informed by evidence. Navigating this process is difficult for decision-makers, clinicians, and researchers alike. This article will describe how a knowledge translation framework and an evidence-based policy-making process were integrated to clarify the problem, frame options, and plan implementation, to impact clinical practice and policy in the area of traumatic spinal cord injury (tSCI)...
October 15, 2017: Journal of Neurotrauma
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