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Ala'a O Oteir, Karen Smith, Johannes U Stoelwinder, Shelley Cox, James W Middleton, Paul A Jennings
BACKGROUND: Traumatic Spinal Cord Injury (TSCI) is relatively uncommon, yet a devastating and costly condition. Despite the human and social impacts, studies describing patients with potential TSCI in the pre-hospital setting are scarce. This paper aims to describe the epidemiology of patients potentially at risk of or suspected to have a TSCI by paramedics, with a view to providing a better understanding of factors associated with potential TSCI. METHODS: This is a retrospective cohort study of all adult patients managed and transported by Ambulance Victoria (AV) between 01 January 2007 and 31 December 2012 who, based on meeting pre-hospital triage protocols and criteria for spinal clearance, paramedic suspicion or spinal immobilisation, were classified to be at risk of or suspected to have a TSCI...
December 2016: Injury Epidemiology
Suliang Chen, Isaac Phang, Argyro Zoumprouli, Marios C Papadopoulos, Samira Saadoun
The management of patients having traumatic spinal cord injury would benefit from understanding and monitoring of spinal cord metabolic states. We hypothesized that the metabolism of the injured spinal cord could be visualized using Kohonen self-organizing maps. Sixteen patients with acute, severe spinal cord injuries were studied. Starting within 72 h of the injury, and for up to a week, we monitored the injury site hourly for tissue glucose, lactate, pyruvate, glutamate, and glycerol using microdialysis as well as intraspinal pressure and spinal cord perfusion pressure...
September 24, 2016: Journal of Neurochemistry
Ginette Thibault-Halman, Carly S Rivers, Christopher Bailey, Eve Tsai, Brian Drew, Vanessa Noonan, Michael Fehlings, Marcel F Dvorak, Dilinuer Kuerban, Brian K Kwon, Sean Christie
Traumatic spinal cord injury (tSCI) represents a significant burden of illness, but is relatively uncommon and heterogeneous, making it challenging to achieve sufficient subject enrollment in clinical trials of therapeutic interventions for acute SCI. The Rick Hansen Spinal Cord Injury Registry (RHSCIR) is a national SCI Registry that enters SCI patients from acute-care centers across Canada. To predict the feasibility of conducting clinical trials of acute SCI within Canada, we have applied the inclusion/exclusion criteria of six previously conducted SCI trials to the RHSCIR dataset and generated estimates of how many Canadian individuals would theoretically have been eligible for enrollment in these studies...
September 14, 2016: Journal of Neurotrauma
Rui Yang, Lan Guo, Lin Huang, Peng Wang, Yong Tang, Jichao Ye, Keng Chen, Xuming Hu, Zhaopeng Cai, Ciyong Lu, Yanfeng Wu, Huiyong Shen
STUDY DESIGN: A hospital-based retrospective epidemiological study. OBJECTIVE: To examine the demographic and epidemiological characteristics of patients with TSCI in Guangdong to help health-related institutions develop measures to determine the best allocation of medical resources. SUMMARY OF BACKGROUND DATA: Traumatic spinal cord injury (TSCI) is a highly disabling and deadly injury. Currently, there is little information regarding the epidemiological characteristics for TSCI in Guangdong...
September 6, 2016: Spine
Amy T Bascom, Abdulghani Sankari, M Safwan Badr
Sleep-disordered breathing (SDB) is prevalent in individuals with chronic spinal cord injury (SCI), but the exact mechanism is unknown. The aim of this study was to investigate whether peripheral chemoreceptors activity is enhanced in individuals with chronic SCI compared to abled-bodied control subjects using CO2 and O2 chemical tests. In protocol (1) 30 subjects (8 cervical [cSCI], 7 thoracic [tSCI] and 15 able-bodied [AB]) were studied to determine the ventilatory response to hyperoxia during wakefulness in the supine position...
September 2016: Physiological Reports
Tim Killeen, Christopher S Easthope, Linard Filli, Michael Linnebank, Armin Curt, Marc Bolliger, Björn Zörner
In healthy subjects, changes in arm swing symmetry while walking are observed when a cognitive dual task is added, with a tendency toward left-dominant arm swing as cognitive load increases. We applied a modified Stroop word/color naming paradigm to investigate this effect in spinal cord injured (SCI) patients. Six patients with cervical SCI (cSCI), 6 with thoracic injuries (tSCI; all 12 patients American Spinal Injury Association [ASIA] Injury Score [AIS]D), and 12 healthy, matched controls underwent three-dimensional 3D gait analysis while walking normally at a comfortable speed (NW) and when performing an additional congruent (CS) and incongruent (IS) Stroop task...
October 12, 2016: Journal of Neurotrauma
Shunyi Wang, Dongliang Ren
Allicin is a major component of garlic, extracted as an oily liquid. The present study was designed to investigate the beneficial effects of allicin on traumatic spinal cord injury (TSCI) in mice, and whether the effects are mediated via regulation of the heat shock protein 70 (HSP70), v‑akt murine thymoma viral oncogene homolog 1 (Akt) and inducible nitric oxide synthase (iNOS) pathways. Adult BALB/c mice (30‑40 g) received a laminectomy at the T9 vertebral level as a model of TSCI. In the present study, treatment of the TSCI mice with allicin significantly increased their Basso, Beattie and Bresnahan (BBB) scores (P<0...
October 2016: Molecular Medicine Reports
I Löfvenmark, M Hasselberg, L Nilsson Wikmar, C Hultling, C Norrbrink
STUDY DESIGN: Prospective follow-up study. OBJECTIVES: To increase the knowledge regarding clinical and functional outcomes after traumatic spinal cord injuries (TSCI) in a resource-constrained setting. A special focus was placed on secondary complications such as pressure ulcers. SETTING: The national referral hospital in Gaborone, Botswana. METHODS: The study included all patients admitted with an acute TSCI during a 2-year period (n=39)...
August 16, 2016: Spinal Cord
Weichao Li, Dianming Jiang, Qiuxia Li, Shaoping Yao, Xianrun Sun, Yong Yang, Zengdong Meng, Wei Liu
AIMS: Lipopolysaccharide (LPS)-induced preconditioning protects neurons against traumatic spinal cord injury (TSCI) in rats. This study sought to test whether Nrf2, a transcription factor, mediated LPS-induced preconditioning. MAIN METHODS: The TSCI model was established using a standardized NYU impactor on adult female rats. Rats were pretreated with LPS (0.2mg/kg, IP; 72h before injury). Nrf2 was silenced by injecting a lentivirus encoding RNAi against Nrf2 into injured spinal cords...
October 1, 2016: Life Sciences
R Chen, X Liu, S Han, D Dong, Y Wang, H Zhang, J Shi, C Zhao, M Yao
STUDY DESIGN: A retrospective hospital-based study. OBJECTIVES: Traumatic spinal cord injury (TSCI) is considered to be an important public health problem worldwide. Only a few studies concerning the regional epidemiological characteristics of TSCI have been published in China. The purpose is to evaluate the epidemiological characteristics of TSCI in Heilongjiang province in northeast China. SETTING: The Second Affiliated Hospital of Harbin Medical University and the Fifth Hospital of Harbin City, Heilongjiang province...
July 26, 2016: Spinal Cord
Benjamin N Breyer, Thomas M Fandel, Amjad Alwaal, E Charles Osterberg, Alan W Shindel, Guiting Lin, Emil A Tanagho, Tom F Lue
OBJECTIVE: To compare the effect of complete transection (tSCI) and contusion injury (cSCI) on bladder function and bladder wall structure in rats. MATERIALS AND METHODS: 30 female Sprague-Dawley rats were randomly divided into three equal groups: uninjured controls, cSCI, and tSCI. The cSCI group underwent spinal cord contusion, while the tSCI group underwent complete spinal cord transection. 24-hour metabolic cage measurement and conscious cystometry were performed at 6 weeks post-injury...
July 19, 2016: BJU International
A Rand, R J Litz, P Zahn
Spinal cord injuries (SCI) are serious medical conditions, which are associated with severe and potentially fatal risks and complications depending on the location and extent of injury. Traffic accidents, falls and recreational activities are the leading causes for traumatic SCI (TSCI) worldwide whereas non-traumatic spinal cord injuries (NTSCI) are mostly due to tumors and congenital diseases. As chronification of the injuries progresses other organ systems are affected including anatomical changes, the respiratory and cardiovascular systems and endocrinological pathways...
July 2016: Der Anaesthesist
M H Sehitoglu, M Guven, Y Yüksel, T Akman, A Bozkurt Aras, A A Farooqi, M Cosar
Spine injury associated with traumatic spinal cord injury eventuates in oxidative stress, inflammation and neuronal apoptosis. The aim of this study is to find out whether the glycyrrhizic acid treatment protects spinal cord from traumatic injuries in rats. To this end, the rats were divided into three groups: group I; control group (no drug or operation, n=8), group II; traumatic spinal cord injury group (TSCI, n=8) and group III; glycyrrhizic acid group (TSCI-GA, 80 mg/kg, n=8). Total laminectomy was performed at T10 level...
2016: Cellular and Molecular Biology
Melissa C Werndle, Samira Saadoun, Isaac Phang, Marek Czosnyka, Georgios Varsos, Zofia Czosnyka, Peter Smielewski, Ali Jamous, B Anthony Bell, Argyro Zoumprouli, Marios C Papadopoulos
Intracranial pressure (ICP) is routinely measured in patients with severe traumatic brain injury (TBI). We describe a novel technique that allowed us to monitor intraspinal pressure (ISP) at the injury site in 14 patients who had severe acute traumatic spinal cord injury (TSCI), analogous to monitoring ICP after brain injury. A Codman probe was inserted subdurally to measure the pressure of the injured spinal cord compressed against the surrounding dura. Our key finding is that it is feasible and safe to monitor ISP for up to a week in patients after TSCI, starting within 72 h of the injury...
2016: Acta Neurochirurgica. Supplement
Conran Joseph, Kerstin Wahman, Julie Phillips, Lena Nilsson Wikmar
BACKGROUND: The development of rehabilitation services promoting participation in people living with a traumatic spinal cord injury (TSCI) is of major concern for physical therapists. What the client sees as effective participation, barriers, and facilitators might be different due to their particular context. This study was conducted to gain insight into the experiences of attaining an important outcome in a developing context. OBJECTIVE: The aim of this study was to explore the experiences of reclaiming participation in community-dwelling people with TSCI in South Africa...
September 2016: Physical Therapy
Liis Sabre, Jaanus Harro, Diva Eensoo, Mariliis Vaht, Vaike Kabel, Malle Pakkanen, Toomas Asser, Janika Kõrv
Several behavioral factors such as violence, impulsivity, and alcohol-related problems are associated with traumatic spinal cord injury (TSCI). Such factors have been associated with inherently low neuronal serotonergic capacity that in turn is reflected in low activity of monoamine oxidase (MAO) as measured in platelets. The aim of the study was to characterize platelet MAO activity and impulsivity in persons with TSCI. Data were collected from 93 patients with TSCI and compared with 93 age- and gender-matched control subjects...
May 16, 2016: Journal of Neurotrauma
R Osterthun, F W A van Asbeck, J H B Nijendijk, M W M Post
STUDY DESIGN: Explorative retrospective files study. OBJECTIVES: To document end-of-life decisions (ELDs) in in-hospital deaths after new traumatic spinal cord injury (TSCI). SETTING: The Netherlands. METHODS: Discharge letters concerning patients with TSCI discharged from Dutch acute hospitals in 2010 were analysed. Data were extracted on survival, personal and lesion characteristics, comorbidities, other injuries, preexisting spinal stenosis, stabilising surgery, length of hospital stay and the presence and types of ELDs...
April 12, 2016: Spinal Cord
B Zárate-Kalfópulos, A Jiménez-González, A Reyes-Sánchez, R Robles-Ortiz, E E Cabrera-Aldana, L M Rosales-Olivarez
STUDY DESIGN: Retrospective study. OBJECTIVES: To evaluate the demographic and clinical characteristics of patients diagnosed with spinal cord injury (SCI) admitted to a single center. SETTING: Single center study, México. METHODS: This study reviewed 433 patients with SCI. Data were extracted from medical records and retrospectively reviewed. RESULTS: A total of 433 patients with a diagnosis of SCI were included in the analysis...
April 12, 2016: Spinal Cord
Blayne Welk, Kuan Liu, Salimah Z Shariff
OBJECTIVE: To assess the use of urologic investigations among traumatic spinal cord injury (TSCI) patients. METHODS: This is a retrospective cohort study from Ontario, Canada. We included all adult TSCI patients injured between 2002 and 2012. The primary outcome was the frequency of urodynamic testing, renal imaging, and cystoscopy. Primary exposure was the year of injury. The impact of age, sex, comorbidity, socioeconomic status, and lesion level was assessed with Cox regression models...
2016: Research and Reports in Urology
Oswaldo Juarez Becerril, Hermelinda Salgado Ceballos, Candy Anguiano Solis, Belen Alvarado Sanchez, Monica Elba Lopez Hernandez, Araceli Diaz Ruiz, Sergio Torres Castillo
In the present study, the effect of electro-acupuncture (EA) on the oxidative stress, the spinal cord tissue preservation and the recovery of motor function was evaluated after a traumatic spinal cord injury (TSCI). Long Evans rats were randomized into five groups: 1. Sham; 2. TSCI without treatment; 3. TSCI + EA (acupoint GV.4); 4. TSCI + EA (acupoint GV.26) and 5.TSCI + EA (GV.4 + GV.26). The EA was performed with an Electro-Acupunctoscope, AWQ-104L Digital, wave dense-dispersed, current intensity 2.5mA and frequency 2-100Hz for 30 minutes...
2015: Acupuncture & Electro-therapeutics Research
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