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https://www.readbyqxmd.com/read/28325105/geomapping-of-traumatic-spinal-cord-injury-in-canada-and-factors-related-to-triage-pattern
#1
Christiana L Cheng, Vanessa K Noonan, Jayson Shurgold, Jason Chen, Carly S Rivers, Hamid Khaleghi Hamedani, Suzanne Humphreys, Christopher Bailey, Najmedden Attabib, Jean-Marc Mac-Thiong, Michael Goytan, Jérôme Paquet, Richard Fox, Henry Ahn, Brian K Kwon, Daryl R Fourney
Current research indicates that more than half of patients with traumatic spinal cord injury (tSCI) experience delays in transfer and receive surgery more than 24 hours post-injury. The objectives of this study were to determine the geographic distribution of tSCI in Canada relative to specialized treatment facilities, to assess clinical and logistical factors at play for indirect admissions to those facilities, and to explore differences in current time to admission and simulated scenarios in an attempt to assess the potential impact of changes to triage protocols...
March 22, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28319547/methylprednisolone-therapy-in-acute-traumatic-spinal-cord-injury-analysis-of-a-regional-spinal-cord-model-systems-database
#2
Jacob E Sunshine, Armagan Dagal, Stephen P Burns, Richard J Bransford, Fangyi Zhang, Shu-Fang Newman, Bala G Nair, Sam R Sharar
BACKGROUND: The objective of this study was to assess the relationship between exposure to methylprednisolone (MP) and improvements in motor function among patients with acute traumatic spinal cord injury (TSCI). MP therapy for patients with TSCI is controversial because of the current conflicting evidence documenting its benefits and risks. METHODS: We conducted a retrospective cohort study from September 2007 to November 2014 of 311 patients with acute TSCI who were enrolled into a model systems database of a regional, level I trauma center...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28285549/methodology-of-the-access-to-care-and-timing-simulation-model-for-traumatic-spinal-cord-injury-care
#3
Argelio Santos, Nader Fallah, Rachel Lewis, Marcel F Dvorak, Michael G Fehlings, Anthony Scott Burns, Vanessa K Noonan, Christiana L Cheng, Elaine Chan, Anoushka Singh, Lise M Belanger, Derek Atkins
Despite the relatively low incidence, the management and care of persons with traumatic spinal cord injury (tSCI) can be resource intensive and complex, spanning multiple phases of care and disciplines. Using a simulation model built with a system level view of the healthcare system allows for prediction of the impact of interventions on patient and system outcomes from injury through to community reintegration after tSCI. The Access to Care and Timing (ACT) project developed a simulation model for tSCI care using techniques from operations research and its development has been described previously...
March 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28260098/identification-of-crucial-genes-associated-with-rat-traumatic-spinal-cord-injury
#4
Zibin Yang, Qiao Lv, Zhengxiang Wang, Xiliang Dong, Rongxin Yang, Wei Zhao
The aim of the present study was to investigate the key genes associated with traumatic spinal cord injuries (TSCI). The dataset GSE52763 was downloaded from the Gene Expression Omnibus, for which lumbar spinal cord samples were obtained from rats at 1 and 3 weeks following contusive spinal cord injury and 1 week subsequent to a sham laminectomy, and used to identify differentially expressed genes (DEGs). Functional enrichment analysis, co‑expression analysis and transcription factor (TF) identification were performed for DEGs common to the 1 and 3 week injury samples...
March 1, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28230791/the-temporal-pattern-flux-and-function-of-autophagy-in-spinal-cord-injury
#5
REVIEW
Kailiang Zhou, Charles A Sansur, Huazi Xu, Xiaofeng Jia
Previous studies have indicated that autophagy plays a critical role in spinal cord injury (SCI), including traumatic spinal cord injury (TSCI) and ischemia-reperfusion spinal cord injury (IRSCI). However, while the understanding of mechanisms underlying autophagy in SCI has progressed, there remain several controversial points: (1) temporal pattern results of autophagic activation after SCI are not consistent across studies; (2) effect of accumulation of autophagosomes due to the blockade or enhancement of autophagic flux is uncertain; (3) overall effect of enhanced autophagy remains undefined, with both beneficial and detrimental outcomes reported in SCI literature...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28195230/epidemiology-of-traumatic-spinal-cord-injury-in-galicia-spain-trends-over-a-20-year-period
#6
A Montoto-Marqués, M E Ferreiro-Velasco, S Salvador-de la Barrera, V Balboa-Barreiro, A Rodriguez-Sotillo, R Meijide-Failde
STUDY DESIGN: Observational study with prospective and retrospective monitoring. OBJECTIVE: To describe the epidemiological and demographic characteristics of traumatic spinal cord injury (TSCI), and to analyze its epidemiological changes. SETTING: Unidad de Lesionados Medulares, Complejo Hospitalario Universitario A Coruña, in Galicia (Spain). METHODS: The study included patients with TSCI who had been hospitalized between January 1995 and December 2014...
February 14, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28104707/improving-care-standards-for-patients-with-spinal-trauma-combining-a-modified-e-delphi-process-and-stakeholder-interviews-a-study-protocol
#7
Lisa N Sharwood, Ralph Stanford, James W Middleton, Brian Burns, Anthony Joseph, Oliver Flower, Oran Rigby, Jonathon Ball, Shelly Dhaliwal
INTRODUCTION: Around 300 people sustain a new traumatic spinal cord injury (TSCI) in Australia each year; a relatively low incidence injury with extremely high long-term associated costs. Care standards are inconsistent nationally, lacking in consensus across important components of care such as prehospital spinal immobilisation, timing of surgery and timeliness of transfer to specialist services. This study aims to develop 'expertly defined' and agreed standards of care across the majority of disciplines involved for these patients...
January 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/28081205/anxiety-and-depression-in-patients-with-traumatic-spinal-cord-injury-a-nationwide-population-based-cohort-study
#8
Sher-Wei Lim, Yow-Ling Shiue, Chung-Han Ho, Shou-Chun Yu, Pei-Hsin Kao, Jhi-Joung Wang, Jinn-Rung Kuo
BACKGROUND: Traumatic spinal cord injury (tSCI) may involve new-onset anxiety and depression post-discharge. However, long-term population-based studies have lacked access to follow-up conditions in terms of new-onset anxiety and depression. The objective of this study was to estimate the long-term risk of new-onset anxiety and depression post-discharge. METHODS: The Longitudinal Health Insurance Database 2000 (LHID2000) from Taiwan's National Health Insurance Research Database was used in this study...
2017: PloS One
https://www.readbyqxmd.com/read/27912248/mean-arterial-blood-pressure-management-of-acute-traumatic-spinal-cord-injured-patients-during-the-pre-hospital-and-early-admission-period
#9
Jin W Tee, Farhaan Altaf, Lise Belanger, Tamir Ailon, John Street, Scott Paquette, Michael Boyd, Charles G Fisher, Marcel F Dvorak, Brian K Kwon
The optimization and maintenance of mean arterial blood pressure (MAP) and the general avoidance of systemic hypotension for the first 5-7 days following acute traumatic spinal cord injury (tSCI) is considered to be important for minimizing secondary spinal cord ischemic damage. The characterization of hemodynamic parameters in the immediate post-injury stage prior to admission to a specialized spine unit has not been previously reported. Here we describe the blood pressure management of 40 acute tSCI patients in the early post-injury phases of care prior to their arrival in a specialized spinal injury high dependency unit (HDU), intensive care unit (ICU), or operating room (OR)...
March 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27824058/survival-after-traumatic-spinal-cord-injury-in-denmark-a-hospital-based-study-among-patients-injured-in-1990-2012
#10
B B Noe, C M Stapelfeldt, E T Parner, E M Mikkelsen
STUDY DESIGN: Hospital-based cohort study at Spinal Cord Injury Centre of Western Denmark (VCR). OBJECTIVE: To examine the overall survival and mortality over time adjusted for age at the time of injury and gender. METHODS: Review of medical records of traumatic spinal cord injury (TSCI) patients admitted at VCR between 1990 and 2012. The patients were followed up until death, emigration or end of study (December 2014). Survival and mortality rate ratios (MRRs) with 95% confidence intervals (CI) were estimated for sub-groups defined by year of injury (1990-1994, 1995-1999, 2000-2004, 2005-2009 and 2010-2012)...
November 8, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27813488/-epidemiology-of-spinal-cord-injury-in-iceland-from-1975-to-2014
#11
Eyrún Arna Kristinsdottir, Sigrun Knutsdottir, Kristinn Sigvaldason, Halldor Jonsson, Pall E Ingvarsson
INTRODUCTION: Traumatic spinal cord injury (TSCI) is serious and often has long-term consequences. Since no cure has been found the emphasis has been on preventive measures. The incidence of TSCI varies between countries and the epidemiology has been changing. The aim of this study was to gather epidemiological data on patients with TSCI in Iceland and search for risk factors. MATERIAL AND METHODS: Hospital records of everyone diagnosed with TSCI in 1975-2014 admitted to Landspitali University Hospital were reviewed and information gathered on incidence, age, gender and causes of injury...
November 2016: Læknablađiđ
https://www.readbyqxmd.com/read/27747560/the-epidemiology-of-pre-hospital-potential-spinal-cord-injuries-in-victoria-australia-a-six-year-retrospective-cohort-study
#12
Ala'a O Oteir, Karen Smith, Johannes U Stoelwinder, Shelley Cox, James W Middleton, Paul A Jennings
BACKGROUND: Traumatic Spinal Cord Injury (TSCI) is relatively uncommon, yet a devastating and costly condition. Despite the human and social impacts, studies describing patients with potential TSCI in the pre-hospital setting are scarce. This paper aims to describe the epidemiology of patients potentially at risk of or suspected to have a TSCI by paramedics, with a view to providing a better understanding of factors associated with potential TSCI. METHODS: This is a retrospective cohort study of all adult patients managed and transported by Ambulance Victoria (AV) between 01 January 2007 and 31 December 2012 who, based on meeting pre-hospital triage protocols and criteria for spinal clearance, paramedic suspicion or spinal immobilisation, were classified to be at risk of or suspected to have a TSCI...
December 2016: Injury Epidemiology
https://www.readbyqxmd.com/read/27664973/metabolic-profile-of-injured-human-spinal-cord-determined-using-surface-microdialysis
#13
Suliang Chen, Isaac Phang, Argyro Zoumprouli, Marios C Papadopoulos, Samira Saadoun
The management of patients having traumatic spinal cord injury would benefit from understanding and monitoring of spinal cord metabolic states. We hypothesized that the metabolism of the injured spinal cord could be visualized using Kohonen self-organizing maps. Sixteen patients with acute, severe spinal cord injuries were studied. Starting within 72 h of the injury, and for up to a week, we monitored the injury site hourly for tissue glucose, lactate, pyruvate, glutamate, and glycerol using microdialysis as well as intraspinal pressure and spinal cord perfusion pressure...
September 24, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27627704/predicting-recruitment-feasibility-for-acute-spinal-cord-injury-clinical-trials-in-canada-using-national-registry-data
#14
Ginette Thibault-Halman, Carly S Rivers, Christopher S Bailey, Eve C Tsai, Brian Drew, Vanessa K Noonan, Michael G Fehlings, Marcel F Dvorak, Dilinuer Kuerban, Brian K Kwon, Sean D Christie
Traumatic spinal cord injury (SCI) represents a significant burden of illness, but it is relatively uncommon and heterogeneous, making it challenging to achieve sufficient subject enrollment in clinical trials of therapeutic interventions for acute SCI. The Rick Hansen Spinal Cord Injury Registry (RHSCIR) is a national SCI Registry that enters patients with SCI from acute-care centers across Canada. To predict the feasibility of conducting clinical trials of acute SCI within Canada, we have applied the inclusion/exclusion criteria of six previously conducted SCI trials to the RHSCIR data set and generated estimates of how many Canadian persons would have been eligible theoretically for enrollment in these studies...
February 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27607312/epidemiological-characteristics-of-traumatic-spinal-cord-injury-in-guangdong-china
#15
Rui Yang, Lan Guo, Lin Huang, Peng Wang, Yong Tang, Jichao Ye, Keng Chen, Xuming Hu, Zhaopeng Cai, Ciyong Lu, Yanfeng Wu, Huiyong Shen
STUDY DESIGN: A hospital-based retrospective epidemiological study. OBJECTIVE: To examine the demographic and epidemiological characteristics of patients with TSCI in Guangdong to help health-related institutions develop measures to determine the best allocation of medical resources. SUMMARY OF BACKGROUND DATA: Traumatic spinal cord injury (TSCI) is a highly disabling and deadly injury. Currently, there is little information regarding the epidemiological characteristics for TSCI in Guangdong...
September 6, 2016: Spine
https://www.readbyqxmd.com/read/27597767/spinal-cord-injury-is-associated-with-enhanced-peripheral-chemoreflex-sensitivity
#16
Amy T Bascom, Abdulghani Sankari, M Safwan Badr
Sleep-disordered breathing (SDB) is prevalent in individuals with chronic spinal cord injury (SCI), but the exact mechanism is unknown. The aim of this study was to investigate whether peripheral chemoreceptors activity is enhanced in individuals with chronic SCI compared to abled-bodied control subjects using CO2 and O2 chemical tests. In protocol (1) 30 subjects (8 cervical [cSCI], 7 thoracic [tSCI] and 15 able-bodied [AB]) were studied to determine the ventilatory response to hyperoxia during wakefulness in the supine position...
September 2016: Physiological Reports
https://www.readbyqxmd.com/read/27574966/modulating-arm-swing-symmetry-with-cognitive-load-a-window-on-rhythmic-spinal-locomotor-networks-in-humans
#17
Tim Killeen, Christopher S Easthope, Linard Filli, Michael Linnebank, Armin Curt, Marc Bolliger, Björn Zörner
In healthy subjects, changes in arm swing symmetry while walking are observed when a cognitive dual task is added, with a tendency toward left-dominant arm swing as cognitive load increases. We applied a modified Stroop word/color naming paradigm to investigate this effect in spinal cord injured (SCI) patients. Six patients with cervical SCI (cSCI), 6 with thoracic injuries (tSCI; all 12 patients American Spinal Injury Association [ASIA] Injury Score [AIS]D), and 12 healthy, matched controls underwent three-dimensional 3D gait analysis while walking normally at a comfortable speed (NW) and when performing an additional congruent (CS) and incongruent (IS) Stroop task...
October 12, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27573340/allicin-protects-traumatic-spinal-cord-injury-through-regulating-the-hsp70-akt-inos-pathway-in-mice
#18
Shunyi Wang, Dongliang Ren
Allicin is a major component of garlic, extracted as an oily liquid. The present study was designed to investigate the beneficial effects of allicin on traumatic spinal cord injury (TSCI) in mice, and whether the effects are mediated via regulation of the heat shock protein 70 (HSP70), v‑akt murine thymoma viral oncogene homolog 1 (Akt) and inducible nitric oxide synthase (iNOS) pathways. Adult BALB/c mice (30‑40 g) received a laminectomy at the T9 vertebral level as a model of TSCI. In the present study, treatment of the TSCI mice with allicin significantly increased their Basso, Beattie and Bresnahan (BBB) scores (P<0...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27527239/outcomes-after-acute-traumatic-spinal-cord-injury-in-botswana-from-admission-to-discharge
#19
I Löfvenmark, M Hasselberg, L Nilsson Wikmar, C Hultling, C Norrbrink
STUDY DESIGN: Prospective follow-up study. OBJECTIVES: To increase the knowledge regarding clinical and functional outcomes after traumatic spinal cord injuries (TSCI) in a resource-constrained setting. A special focus was placed on secondary complications such as pressure ulcers. SETTING: The national referral hospital in Gaborone, Botswana. METHODS: The study included all patients admitted with an acute TSCI during a 2-year period (n=39)...
February 2017: Spinal Cord
https://www.readbyqxmd.com/read/27515502/lipopolysaccharide-induced-preconditioning-protects-against-traumatic-spinal-cord-injury-by-upregulating-nrf2-expression-in-rats
#20
Weichao Li, Dianming Jiang, Qiuxia Li, Shaoping Yao, Xianrun Sun, Yong Yang, Zengdong Meng, Wei Liu
AIMS: Lipopolysaccharide (LPS)-induced preconditioning protects neurons against traumatic spinal cord injury (TSCI) in rats. This study sought to test whether Nrf2, a transcription factor, mediated LPS-induced preconditioning. MAIN METHODS: The TSCI model was established using a standardized NYU impactor on adult female rats. Rats were pretreated with LPS (0.2mg/kg, IP; 72h before injury). Nrf2 was silenced by injecting a lentivirus encoding RNAi against Nrf2 into injured spinal cords...
October 1, 2016: Life Sciences
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