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https://www.readbyqxmd.com/read/28438543/modulation-of-motor-cortex-excitability-predicts-antidepressant-response-to-prefrontal-cortex-repetitive-transcranial-magnetic-stimulation
#1
Albino J Oliveira-Maia, Daniel Press, Alvaro Pascual-Leone
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) is a treatment option for patients with medication-resistant major depressive disorder (MDD). However, antidepressant response is variable and there are currently no response predictors with sufficient accuracy for clinical use. OBJECTIVE: We report on results of an observational open-label study to determine whether the modulatory effect of 10 Hz motor cortex (MC) rTMS is predictive of the antidepressant effect of 10 Hz DLPFC rTMS...
March 31, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28436812/retrospective-waveform-analysis-of-transcranial-motor-evoked-potentials-mep-to-identify-early-predictors-of-impending-motor-deficits-in-spinal-surgeries
#2
Scheherazade Le, Viet Nguyen, Alexander C Ekwueme, S Charles Cho, Leslie Lee, Jaime López
PURPOSE: Although there are guidelines analyzing transcranial motor evoked potentials (MEP) waveform criteria, they vary widely and are not applied universally during intraoperative neurophysiologic monitoring (IONM). The objective is to generate hypotheses to identify early and reliable MEP waveform characteristics prior to complete loss of MEP to predict impending motor spinal cord injuries during spinal surgeries. The ultimate goal is to enhance real-time feedback to prevent injury or detect reversible spinal cord damage...
2017: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/28432459/using-an-anatomically-preshaped-low-profile-locking-plate-system-leads-to-reliable-results-in-comminuted-radial-head-fractures
#3
Moritz Crönlein, Michael Zyskowski, Marc Beirer, Florian B Imhoff, Dominik Pförringer, Gunther H Sandmann, Chlodwig Kirchhoff, Peter Biberthaler, Sebastian Siebenlist
INTRODUCTION: For comminuted and displaced fractures of the radial head open reduction and internal fixation (ORIF) is recommended nowadays as the treatment of choice. Due to the development of locking plates the possibilities of ORIF in complex fracture types were extended. The purpose of this retrospective survey therefore was to review the preliminary subjective and objective results in patients treated by anatomically preshaped locked plating. A reliable fracture healing for these recently introduced plating devices was hypothesized...
April 21, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28431989/live-birth-miscarriage-and-abortion-among-u-s-women-with-and-without-disabilities
#4
Willi Horner-Johnson, Sheetal Kulkarni-Rajasekhara, Blair G Darney, Mekhala Dissanayake, Aaron B Caughey
BACKGROUND: Prior studies have found that women with disabilities who give birth are more likely to have preterm deliveries and low birthweight infants. However, it is not known what proportion of pregnant women with disabilities experience live birth, versus miscarriage or abortion. OBJECTIVE: To compare proportions of live birth, miscarriage, and abortion among women with basic action difficulties, women with complex activity limitations, and women without disabilities in a nationally representative sample...
April 6, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28428039/antimicrobial-mechanism-of-epigallocatechin-gallate-and-gallocatechin-gallate-they-target-1-deoxy-d-xylulose-5-phosphate-reductoisomerase-the-key-enzyme-of-the-mep-terpenoid-biosynthetic-pathway
#5
Xian Hui, Shui-Hong Hua, Qian-Qian Wu, Heng Li, Wen-Yun Gao
The catechins EGCG and GCG show a variety of pharmacological activities, especially an antibacterial capacity, but their modes of antimicrobial action have not been fully elucidated. 1-Deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), the first key enzyme in the MEP pathway for terpenoid biosynthesis, is a recently validated antimicrobial target. In order to disclose the antibacterial mechanism of EGCG and GCG, the DXR inhibitory activity of them was investigated in this study. The data show that EGCG and GCG both could specifically suppress the activity of DXR, with EGCG exhibiting relatively low effect against DXR (IC50 about 210 μM) and GCG displaying strong activity (IC50 27...
April 18, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28428009/effect-of-methylparaben-in-artemia-franciscana
#6
Amparo Comeche, María Martín-Villamil, Yolanda Pico, Inma Varó
In this study, the toxicity of methylparaben (MeP) an emerging contaminant, was analyzed in the sexual species Artemia franciscana, due to its presence in coastal areas and marine saltworks in the Mediterranean region. The acute toxicity (24h-LC50) of MeP in nauplii was tested and its chronic effect (9days) evaluated by measuring survival and growth under two sublethal concentrations (0.0085 and 0.017mg/L). Also, the effect on several key enzymes involved in: antioxidant defences (catalase (CAT) and gluthathion-S-transferase (GST)), neural activity (cholinesterase (ChE)) and xenobiotic biotransformation (carboxylesterase (CbE), was assessed after 48h under sublethal exposure...
April 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28426992/factors-affecting-sound-energy-absorbance-in-acute-otitis-media-model-of-chinchilla
#7
Xiying Guan, Thomas W Seale, Rong Z Gan
Acute otitis media (AOM) is a rapid-onset infection of the middle ear which results in middle ear pressure (MEP), middle ear effusion (MEE), and structural changes in middle ear tissues. Previous studies from our laboratory have identified that MEP, MEE, and middle ear structural changes are three factors affecting tympanic membrane (TM) mobility and hearing levels (Guan et al., 2014, 2013). Sound energy reflectance or absorbance (EA) is a diagnostic tool increasingly used in clinical settings for the identification of middle ear diseases...
April 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28423347/experimental-study-of-brachial-plexus-and-vessel-compression-evaluation-of-combined-central-and-peripheral-electrodiagnostic-approach
#8
Chaoqun Yang, Jianguang Xu, Jie Chen, Shulin Li, Yu Cao, Yi Zhu, Lei Xu
INTRODUCTION: We sought to investigate the reliability of a new electrodiagnostic method for identifying Electrodiagnosis of Brachial Plexus & Vessel Compression Syndrome (BPVCS) in rats that involves the application of transcranial electrical stimulation motor evoked potentials (TES-MEPs) combined with peripheral nerve stimulation compound muscle action potentials (PNS-CMAPs). RESULTS: The latencies of the TES-MEP and PNS-CMAP were initially elongated in the 8-week group...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412970/membrane-potential-independent-transport-of-nh3-in-the-absence-of-ammonium-permeases-in-saccharomyces-cerevisiae
#9
Hugo F Cueto-Rojas, Nicholas Milne, Ward van Helmond, Mervin M Pieterse, Antonius J A van Maris, Jean-Marc Daran, S Aljoscha Wahl
BACKGROUND: Microbial production of nitrogen containing compounds requires a high uptake flux and assimilation of the N-source (commonly ammonium), which is generally coupled with ATP consumption and negatively influences the product yield. In the industrial workhorse Saccharomyces cerevisiae, ammonium (NH4(+)) uptake is facilitated by ammonium permeases (Mep1, Mep2 and Mep3), which transport the NH4(+) ion, resulting in ATP expenditure to maintain the intracellular charge balance and pH by proton export using the plasma membrane-bound H(+)-ATPase...
April 17, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28412564/outcomes-of-patients-with-syringomyelia-undergoing-spine-deformity-surgery-do-large-syrinxes-behave-differently-than-small
#10
Amer F Samdani, Steven W Hwang, Anuj Singla, James T Bennett, Robert J Ames, Jeff S Kimball
BACKGROUND CONTEXT: A paucity of data exists studying outcomes of patients with syringomyelia undergoing spinal deformity correction. The literature does not stratify patients by syrinx size, which is likely a major contributor to outcomes. PURPOSE: To compare differences in outcomes between patients with large (≥ 4mm) and small syrinxes (< 4mm) undergoing spinal deformity correction. DESIGN: Retrospective review PATIENT SAMPLE: 28 patients (11 with large syrinx [LS, ≥ 4mm] and 17 with small syrinx [SS, < 4mm])...
April 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28409395/spinal-and-corticospinal-pathways-are-differently-modulated-when-standing-at-the-bottom-and-the-top-of-a-three-step-staircase-in-young-and-older-adults
#11
Johanna Johannsson, Jacques Duchateau, Stéphane Baudry
PURPOSE: This study investigated the modulation of spinal (group Ia afferents) and corticospinal pathways when young (22.7 ± 1.3 years) and older adults (72.2 ± 7.9 years) stood at the bottom and at the top of a three-step staircase equipped with force platforms. METHOD: Changes in submaximal H-reflex amplitude (H 50) and slope of the H-reflex input-output relation (spinal pathway), and in amplitude of motor-evoked potentials (MEP) triggered by transcranial magnetic stimulation (corticospinal pathway) at two intensities (1...
April 13, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28409130/acute-distal-biceps-ruptures-single-incision-repair-by-use-of-suture-anchors
#12
Rafael Almeida Maciel, Priscilla Silva Costa, Eduardo Antônio Figueiredo, Paulo Santoro Belangero, Alberto de Castro Pochini, Benno Ejnisman
OBJECTIVE: Clinical and functional assessment of the surgical treatment for acute injury of the distal insertion of the biceps brachial performed with a surgical technique using a single incision in proximal forearm and fixation with suture anchors in the radial tuberosity. METHODS: This study reviewed the medical records of patients who underwent surgical treatment of distal biceps injury during the period between January 2008 and July 2014. In a mean follow-up of 12 months, 22 patients with complete and acute injury, diagnosed through physical examination and imaging studies, were functionally assessed in the postoperative period regarding the range of motion (degrees of flexion-extension and pronation-supination), the presence of pain (VAS), the Andrews Carson-score, and the Mayo Elbow Performance Score (MEPS)...
March 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28407776/trends-of-medical-expenditures-and-quality-of-life-in-us-adults-with-diabetes-the-medical-expenditure-panel-survey-2002-2011
#13
Jennifer A Campbell, Kinfe G Bishu, Rebekah J Walker, Leonard E Egede
BACKGROUND: Studies indicate a relationship between cost and quality of life (QOL) in diabetes care, however, the interaction is complex and the relationship is not well understood. The aim of this study was to 1) examine the relationship of quartiles of QOL on cost amongst U.S. adults with diabetes, 2) investigate how the relationship may change over time, and 3) examine the incremental effect of QOL on cost while controlling for other relevant covariates. METHODS: Data from 2002-2011 Medical Expenditure Panel Survey (MEPS) was used to examine the association between QOL and medical expenditures among adults with diabetes (aged ≥18 years) N = 20,442...
April 13, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28405785/determination-of-the-potential-implementation-impact-of-2016-ministry-of-environmental-protection-generic-assessment-criteria-for-potentially-contaminated-sites-in-china
#14
Yuanyuan Cheng, Yu-Ting Tang, C Paul Nathanail
The Ministry of Environmental Protection of China issued a 3rd draft edition of risk-based Generic Assessment Criteria (the MEP-GAC) in March 2016. Since these will be the first authoritative GAC in China, their implementation is likely to have a significant impact on China's growing contaminated land management sector. This study aims to determine the potential implementation impact of the MEP-GAC through an in-depth analysis of the management context, land use scenarios, health criteria values adopted and exposure pathways considered...
April 12, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28405184/optical-imaging-of-the-motor-cortex-following-antidromic-activation-of-the-corticospinal-tract-after-spinal-cord-injury
#15
Kyung H Lee, Un J Kim, Se W Park, Yong G Park, Bae H Lee
Spinal cord injury (SCI) disrupts neuronal networks of ascending and descending tracts at the site of injury, leading to a loss of motor function. Restoration and new circuit formation are important components of the recovery process, which involves collateral sprouting of injured and uninjured fibers. The present study was conducted to determine cortical responses to antidromic stimulation of the corticospinal tracts, to compare changes in the reorganization of neural pathways within normal and spinal cord-injured rats, and to elucidate differences in spatiotemporal activity patterns of the natural progression and reorganization of neural pathways in normal and SCI animals using optical imaging...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28404231/modulation-of-sensorimotor-circuits-during-retrieval-of-negative-autobiographical-memories-exploring-the-impact-of-personality-dimensions
#16
Ludovico Mineo, Carmen Concerto, Dhaval Patel, Tyrone Mayorga, Eileen Chusid, Carmenrita Infortuna, Eugenio Aguglia, Yasmin Sarraf, Fortunato Battaglia
Autobiographical Memory (AM) retrieval refers to recollection of experienced past events. Previous Transcranial Magnetic Stimulation (TMS) studies have shown that presentation of emotional negative stimuli affects human motor cortex excitability resulting in larger motor evoked potentials (MEPs). Up to date no TMS studies have been carried out in order to investigate the effect of personal memories with negative emotional value on corticospinal excitability. In this study we hypothesized that negative AM retrieval will modulate corticomotor excitability and sensorimotor integration as determined by TMS neurophysiological parameters...
April 9, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28403421/reply-allostatic-load-as-an-approach-to-support-the-theoretical-assumptions-of-the-brief-measure-of-emotional-preoperative-stress-b-meps
#17
W Caumo, J D Segabinazi, L P C Stefani
No abstract text is available yet for this article.
April 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28399624/effect-of-respiratory-muscle-training-on-pulmonary-function-and-aerobic-endurance-in-soccer-players
#18
Tarik Ozmen, Gokce Y Gunes, Ilyas Ucar, Hanife Dogan, Tuba U Gafuroglu
BACKGROUND: Few studies investigated the effects of the respiratory muscle training (RMT) in soccer although exhaustive high intensity exercise is known to lead to muscle fatigue in respiratory muscles. The purpose of this study was to investigate the effect of RMT on pulmonary function and aerobic endurance in soccer players. METHODS: Eighteen male soccer players (mean age 22.2±1.4 years) participated in this study. Participants were assigned randomly to either an RMT or a control (CON) group...
May 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28394608/second-generation-triple-helical-peptide-inhibitors-of-matrix-metalloproteinases
#19
Manishabrata Bhowmick, Dorota Tokmina-Roszyk, Lillian Onwuha-Ekpete, Kelli Harmon, Trista Robichaud, Rita Fuerst, Roma Stawikowska, Bjorn Steffensen, William Roush, Hector R Wong, Gregg B Fields
The design of selective matrix metalloproteinase (MMP) inhibitors that also possess favorable solubility properties has proved to be especially challenging. A prior approach using collagen-model templates combined with transition state analogs produced a first generation of triple-helical peptide inhibitors (THPIs) that were effective in vitro against discrete members of the MMP family. These THPI constructs were also highly water-soluble. The present study sought improvements in the first generation THPIs by enhancing thermal stability and selectivity...
April 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28394475/dynamical-entrainment-of-corticospinal-excitability-during-rhythmic-movement-observation-a-tms-study
#20
Manuel Varlet, Giacomo Novembre, Peter E Keller
Spontaneous modulations of corticospinal excitability during action observation have been interpreted as evidence for the activation of internal motor representations equivalent to the observed action. Alternatively or complementary to this perspective, growing evidence shows that motor activity during observation of rhythmic movements can be modulated by direct visuomotor couplings and dynamical entrainment. In-phase and anti-phase entrainment spontaneously occur, characterized by cyclic movements proceeding simultaneously in the same (in-phase) or opposite (anti-phase) direction...
April 10, 2017: European Journal of Neuroscience
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