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https://www.readbyqxmd.com/read/29336968/reappearance-of-motor-evoked-potentials-during-the-rewarming-phase-after-deep-hypothermic-circulatory-arrest
#1
Eiki Kanemaru, Kenji Yoshitani, Shinya Kato, Yuichi Tanaka, Yoshihiko Ohnishi
OBJECTIVE: Although motor-evoked potentials (MEPs) disappear in deep hypothermic circulatory arrest (DHCA), MEPs have been used to confirm whether motor function is intact after DHCA. It is crucial to know the timing, body temperature, and MEP amplitude at MEP reappearance to detect spinal cord ischemia after DHCA. However, data on these parameters are sparse. The authors investigated the characteristics of MEPs at reappearance after DHCA. DESIGN: A retrospective observational study...
June 1, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29335298/crystal-structure-of-ispf-from-bacillus-subtilis-and-absence-of-protein-complex-assembly-among-ispd-ispe-ispf-enzymes-in-the-mep-pathway
#2
Zhongchuan Liu, Yun Jin, Weifeng Liu, Yong Tao, Ganggang Wang
2-C-methyl-d-erythritol 2, 4-cyclodiphosphate synthase (IspF) is a key enzyme in the 2-C-Methyl-d-erythritol-4-phosphate (MEP) pathway of isoprenoid biosynthesis. This enzyme catalyzes the 4-diphosphocytidyl-2-C-methyl-d-erythritol 2-phosphate (CDPME2P) to 2-C-methyl-d-erythritol 2, 4-cyclodiphosphate (MEcDP) with concomitant release of cytidine 5'-diphospate (cytosine monophosphate) (CMP). Bacillus subtilis is a potential host cell for the production of isoprenoids, but few studies are performed on the key enzymes of MEP pathway in B...
January 15, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29329148/self-reported-health-status-differs-for-amazon-s-mechanical-turk-respondents-compared-with-nationally-representative-surveys
#3
Karoline Mortensen, Manuel G Alcalá, Michael T French, Tianyan Hu
BACKGROUND: Amazon's Mechanical Turk (MTurk) platform has become a data source for peer-reviewed academic research publications, with over 24,000 Google Scholar search results. Although well-developed and supportive in other disciplines, the literature in health and medicine comparing results from samples generated on MTurk to gold standard, nationally representative health and medical surveys is beginning to emerge. OBJECTIVE: To compare the demographic, socioeconomic, and self-reported health status variables in an MTurk sample to those from 2 prominent national probability surveys, including the Medical Expenditure Panel Survey (MEPS) and the Behavioral Risk Factor Surveillance System (BRFSS)...
January 11, 2018: Medical Care
https://www.readbyqxmd.com/read/29327556/-surgical-treatment-for-the-fractures-and-dislocations-of-the-elbow-in-old-patients
#4
Hua Xu, Li-Feng Shen, Hua-Jun Yu, Xiao-Wen Zhang, Qiao-Feng Guo
OBJECTIVE: To introduce and report the preliminary results of 7 old patients with fractures and dislocations of the elbow. METHODS: From July 2011 to August 2015, 7 old patients suffered from fractures and dislocations of the elbow(5 of which were terrible triad). One patient had type Iradial head fracture, 3 type IIand 1 type III according to the Mason classification, and 1 type I, 5 type IIand 1 type III according to the Regan-Morrey classification. All the 7 patients received operation and then were treated with external fixation...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327540/-analysis-on-the-effect-of-surgical-cleaning-combined-with-external-fixator-for-the-treatment-of-post-traumatic-heterotopic-ossification-of-elbow-joint
#5
Liang Yan, Jian-Lei Zhao, Shang-Zeng Wang, Li-Na Feng
OBJECTIVE: To evaluate the clinical efficacy of surgical treatment using a combined medial and lateral approach combined with an external fixator for the treatment of post-traumatic heterotopic ossification(HO) in patients with stiff elbow joints. METHODS: Surgical release using the combined medial and lateral approach combined with external fixation for the treatment of HO and elbow stiffness in 26 patients from July 2010 to December 2013. The study group included 18 males and 8 females, with an average age 38...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29325145/anxiety-dependent-modulation-of-motor-responses-to-pain-expectancy
#6
Carlotta Fossataro, Giulia Bucchioni, Federico D'Agata, Valentina Bruno, Rosalba Morese, Pierre Krystkowiak, Francesca Garbarini
The relationship between pain expectancy and motor system plays a crucial role in the human defensive system. Here, we took advantage of the inhibitory modulation of the motor pathway to the muscle of the hand receiving painful stimuli, by recording motor-evoked potentials (MEPs) to Transcranial Magnetic Stimulation (TMS). We employed a classical conditioning paradigm in which neutral (visual and auditory) stimuli were conditioned by pairing either painful or not-painful stimuli (electric shocks) in separated groups...
January 8, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29320190/electronic-and-nonlinear-optical-properties-of-l-histidine-on-silver-a-theoretical-and-experimental-approach
#7
U Reeta Felscia, Beulah J M Rajkumar, Monickaraj Nidya, Pranitha Sankar
Investigation on the electrostatic interactions between histidine and silver have been analysed using Density Functional Theory (DFT). Variations in the structural parameters were identified to be significant at those atoms of histidine near the silver cluster. Shifting of frontier molecular orbitals, reduction in bandgap, molecular electrostatic potential(MEP) and the overlap of Natural Bond Orbitals(NBO) between silver and histidine have been theoretically calculated. The results confirm the redistribution of charges consequent to the process of adsorption...
January 10, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29317839/surgical-release-for-tubercular-elbow-stiffness
#8
Yun Qian, Qixin Han, Wei Wang, Yuanming Ouyang, Weien Yuan, Cunyi Fan
Background: For decades, tuberculosis (TB) has posed a great threat to people worldwide. Bone and joint TB is one of the most common types of extrapulmonary TB, with elbow TB comprising a small proportion of these cases. The treatment for elbow stiffness associated with TB has been rarely reported. Patients and methods: We retrospectively analyzed six patients (four females and two males) with tubercular elbow stiffness during a 7-year period. All of them received open arthrolysis and hinged external fixation to restore functional extension, flexion, supination and pronation...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29317738/personal-care-product-use-as-a-predictor-of-urinary-concentrations-of-certain-phthalates-parabens-and-phenols-in-the-hermosa-study
#9
Kimberly P Berger, Katherine R Kogut, Asa Bradman, Jianwen She, Qi Gavin, Rana Zahedi, Kimberly L Parra, Kim G Harley
Use of personal care products, such as makeup, soaps, and sunscreen, may expose adolescent girls to potential endocrine disruptors, including phthalates, parabens, and other phenols. We evaluated the relationship between recent self-reported personal care product use and concentrations for urinary metabolites of phthalates, parabens, triclosan, and benzophenone-3 (BP-3) in 100 Latina adolescents. Girls who reported using makeup every day vs. rarely/never had higher urinary concentrations of monoethyl phthalate (MEP) (102...
January 9, 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29317185/cortical-inhibition-assessed-using-paired-pulse-tms-eeg-is-increased-in-older-adults
#10
George M Opie, Simranjit K Sidhu, Nigel C Rogasch, Michael C Ridding, John G Semmler
BACKGROUND: Alterations in inhibitory processes mediated by gamma-aminobutyric acid type B (GABAB) receptors may contribute to age-related functional impairments. However, investigation of these circuits using conventional paired-pulse transcranial magnetic stimulation (TMS) at long interstimulus intervals (∼100-200ms) have produced conflicting results in older adults, possibly due to the indirect nature of the TMS motor evoked potential (MEP). OBJECTIVE: To utilise electroencephalography and TMS coregistration (TMS-EEG) to more directly assess age-related changes in GABAB-mediated long-interval intracortical inhibition (LICI)...
December 30, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29316395/dynamical-effects-along-bifurcation-pathway-control-semibullvalene-formation-in-deazetization-reactions
#11
Nilangshu Mandal, Ayan Datta
Post-transition-state dynamics during the deazetization of 3 resulting in two degenerate semibullvalenes (4 and 5) have been investigated with density functional theory (DFT) and quasi-classical trajectory (QCT) calculations. Removal of N2 from 3 occurs through a synchronous and concerted pathway through an ambimodal transition-state (TS1). In addition to TS2, the exclusively anticipated product from minimum energy pathway (MEP) calculations, trajectories initiated from TS1 produce 4, TS2 and 5 in 1:1:1 ratio...
January 9, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29313181/intraoperative-neurophysiological-monitoring-during-spinal-surgery-technical-review-in-open-and-minimally-invasive-approaches
#12
REVIEW
Fabio Cofano, Francesco Zenga, Marco Mammi, Roberto Altieri, Nicola Marengo, Marco Ajello, Paolo Pacca, Antonio Melcarne, Carola Junemann, Alessandro Ducati, Diego Garbossa
Neurophysiological monitoring is of undoubted value for the intraoperative safety of neurosurgical procedures. Widely developed and used for cranial surgery, it is equally as effective, though perhaps less commonly employed, for spinal pathology. The most frequently used techniques for intraoperative monitoring during spinal surgery include somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs) and electromyography, which can either be spontaneous free-running (sEMG) or triggered (tEMG). The knowledge of the benefits and limitations of each modality is essential in optimising the value of intraoperative monitoring during spinal procedures...
January 8, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29311394/exercise-capacity-and-respiratory-profile-in-patients-after-orthopedic-liver-transplantation-a-follow-up-study
#13
Clarissa B A Magalhães, José Huygens P Garcia, Cyntia F G Viana, Maria José N Flor, Pedro Felipe C de Bruin, Eanes D B Pereira
INTRODUCTION: We sought to describe: 1) The influence of orthotopic liver transplantation (OLT) on exercise capacity, pulmonary function and respiratory muscle strength after surgery, 2) The relationship between exercise capacity and symptoms of anxiety and depression. MATERIAL AND METHODS: This is a prospective follow up study conducted with patients submitted to OLT. All patients were assessed before and 1 month after surgery through measurements: six minute walk test (6MWT), 6 min step test (6MST) and HADS (Hospital Anxiety and Depression Scale)...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29310915/effect-of-disease-duration-on-functional-outcomes-and-complications-after-arthrolysis-in-patients-with-elbow-stiffness
#14
Wei Zheng, Jialin Song, Ziyang Sun, Jiazhi Liu, Shuai Chen, Cunyi Fan
HYPOTHESIS: The purpose of this study was to determine the effect of a long duration of elbow stiffness on functional outcomes and complications after arthrolysis. METHODS: Participants included consecutive patients with a long duration of elbow stiffness (≥5 years, n = 23) and control patients matched for age, sex, and initial injury type (n = 46). All patients underwent elbow arthrolysis combined with hinged external fixation between March 2014 and March 2016...
January 5, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29310333/epidemiologic-features-and-management-of-elbow-dislocation-with-associated-fracture-in-pediatric-population
#15
Xuemin Lu, Guisen Yan, Ming Lu, Yuan Guo
This study was conducted to explore epidemiologic features of traumatic elbow dislocation with associated fractures in pediatric population following appropriate treatment options.Incidence of elbow dislocation with associated fractures was analyzed in 67 children using elbow radiographs. Treatment for the displaced elbow joint was performed by closed reduction and proper immobilization. Surgical intervention was applied to restore the correct alignment of the fracture. Mayo Elbow Performance Score (MEPS) was used to measure elbow joint function...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305917/motor-imagery-of-voluntary-muscle-relaxation-of-the-foot-induces-a-temporal-reduction-of-corticospinal-excitability-in-the-hand
#16
Kouki Kato, Kazuyuki Kanosue
The object of this study was to clarify how the motor imagery of foot muscle relaxation influences corticospinal excitability for the ipsilateral hand. Twelve participants volitionally relaxed their right foot from a dorsiflexed position (actual relaxation), or imaged the same movement (imagery relaxation) in response to an auditory cue. Transcranial magnetic stimulation (TMS) was delivered to the hand area of the left primary motor cortex at different time intervals after an auditory cue. Motor evoked potentials (MEPs) were recorded from the right extensor carpi radialis (ECR) and flexor carpi radialis (FCR)...
January 3, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29304044/directing-visual-attention-during-action-observation-modulates-corticospinal-excitability
#17
David J Wright, Greg Wood, Zoe C Franklin, Ben Marshall, Martin Riach, Paul S Holmes
Transcranial magnetic stimulation (TMS) research has shown that corticospinal excitability is facilitated during the observation of human movement. However, the relationship between corticospinal excitability and participants' visual attention during action observation is rarely considered. Nineteen participants took part in four conditions: (i) a static hand condition, involving observation of a right hand holding a ball between the thumb and index finger; (ii) a free observation condition, involving observation of the ball being pinched between thumb and index finger; and (iii and iv) finger-focused and ball-focused conditions, involving observation of the same ball pinch action with instructions to focus visual attention on either the index finger or the ball...
2018: PloS One
https://www.readbyqxmd.com/read/29300724/a-novel-prospective-isolation-of-murine-fetal-liver-progenitors-to-study-in-utero-hematopoietic-defects
#18
Julia E Draper, Patrycja Sroczynska, Muhammad Z H Fadlullah, Rahima Patel, Gillian Newton, Wolfgang Breitwieser, Valerie Kouskoff, Georges Lacaud
In recent years, highly detailed characterization of adult bone marrow (BM) myeloid progenitors has been achieved and, as a result, the impact of somatic defects on different hematopoietic lineage fate decisions can be precisely determined. Fetal liver (FL) hematopoietic progenitor cells (HPCs) are poorly characterized in comparison, potentially hindering the study of the impact of genetic alterations on midgestation hematopoiesis. Numerous disorders, for example infant acute leukemias, have in utero origins and their study would therefore benefit from the ability to isolate highly purified progenitor subsets...
January 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29297251/the-influence-of-5-fluorouracil-anticancer-drug-on-the-dna-base-pairs-a-quantum-chemical-study
#19
Ebrahim Nakhaei, Alireza Nowroozi, Fateme Ravari
In the present study, various hydrogen bonded complexes between 5-fluorouracil (FU) with AT and GC base pairs were studied. First, to determine the affinity of different sites of the parent structures (FU, AT, and GC) for the hydrogen bond formation, their molecular electrostatic potentials (MEP) are explored. The complexation energies and the strength of individual HBs of the plausible complexes were evaluated by energetic, geometric, spectroscopic, topologic and molecular orbital descriptors. Our results reveal that, the FU-GC complexes (34...
January 3, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29291096/spinal-excitability-is-increased-in-the-torque-depressed-isometric-steady-state-following-active-muscle-shortening
#20
Caleb T Sypkes, Benjamin Kozlowski, Jordan Grant, Leah R Bent, Chris J McNeil, Geoffrey A Power
Torque depression (TD) is the reduction in steady-state isometric torque following active muscle shortening when compared with a purely isometric contraction at the same muscle length and level of activation. The purpose of the present study was to assess spinal and supraspinal excitability in the TD state during submaximal contractions of the dorsiflexors. Eleven young (24 ± 2 yrs) males performed 16 contractions at a constant level of electromyographic activity (40% of maximum). Half of the contractions were purely isometric (8 s at an ankle angle of 100°), whereas the other half induced TD (2 s isometric at 140°, a 1 s shortening phase at 40° s-1 and 5 s at 100°)...
November 2017: Royal Society Open Science
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