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https://www.readbyqxmd.com/read/27932966/combination-of-static-magnetic-fields-and-peripheral-nerve-stimulation-can-alter-focal-cortical-excitability
#1
Ippei Nojima, Satoko Koganemaru, Tatsuya Mima
For clinical application of transcranial static magnetic stimulation (tSMS), it is important to achieve a focal target cortical stimulation. Previous study suggested that the associative stimulation combining non-invasive stimulation of the motor cortex (M1) and the peripheral nerve stimulation (PNS) may be useful to produce cortical excitability change. To test this hypothesis, we measured the M1 excitability and intracortical circuits by using transcranial magnetic stimulation (TMS) before and after the tSMS of short duration (5 min) combined with PNS...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27929075/long-latency-modulation-of-motor-cortex-excitability-by-ipsilateral-posterior-inferior-frontal-gyrus-and-pre-supplementary-motor-area
#2
Francesca Fiori, Emilio Chiappini, Marco Soriano, Riccardo Paracampo, Vincenzo Romei, Sara Borgomaneri, Alessio Avenanti
The primary motor cortex (M1) is strongly influenced by several frontal regions. Dual-site transcranial magnetic stimulation (dsTMS) has highlighted the timing of early (<40 ms) prefrontal/premotor influences over M1. Here we used dsTMS to investigate, for the first time, longer-latency causal interactions of the posterior inferior frontal gyrus (pIFG) and pre-supplementary motor area (pre-SMA) with M1 at rest. A suprathreshold test stimulus (TS) was applied over M1 producing a motor-evoked potential (MEP) in the relaxed hand...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27923761/intraoperative-neurophysiological-monitoring-for-adult-patients-undergoing-posterior-spinal-fusion
#3
Nitin Agarwal, D Kojo Hamilton, Alp Ozpinar, Phillip Choi, Robert Hart, Ilker Yaylali
INTRODUCTION: Somatosensory evoked potentials (SSEP) and motor evoked potentials (MEP) are frequently used to monitor neurological function during spinal deformity surgery. The sensitivity and specificity of intraoperative neurophysiological monitoring (IONM) in patients undergoing posterior spinal fusion (PSF) in debatable. METHODS: A retrospective review of all patients undergoing PSF with IONM from October 2008 to December 2012 was performed. Factors including gender, operative time and spinal levels of posterior fusion were analyzed as risk factors for intraoperative alerts...
December 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27921243/comparison-of-rnai-ngr-and-nep1-40-in-acting-on-axonal-regeneration-after-spinal-cord-injury-in-rat-models
#4
Jing Xu, Jian He, Huang He, Renjun Peng, Jian Xi
This study was intended to compare the therapeutic efficacies of NEP1-40 and SiNgR199 on treating spinal cord injury (SCI). Nogo-A, growth associated protein 43 (GAP-43), microtubule associated protein 2 (MAP-2), and amyloid βA4 precursor protein (APP) expressions were determined using western blot and quantitative PCR. Neurite outgrowth detected the growth of neurites, and BDA anterograde tracing was used to label the regenerated axonal. Rats' behavior was assessed with Basso, Beattie, and Bresnahan locomotor rating scale (BBB)...
December 5, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27920095/functional-characterization-of-the-left-ventrolateral-premotor-cortex-in-humans-a-direct-electrophysiological-approach
#5
L Fornia, V Ferpozzi, M Montagna, M Rossi, M Riva, F Pessina, F Martinelli Boneschi, P Borroni, R N Lemon, L Bello, G Cerri
In monkeys, motor outputs from premotor cortex (PM) involve cortico-cortical connections with primary motor cortex (M1). However, in humans, the functional organization of PM and its relationship with the corticospinal tract (CST) is still uncertain. This study was carried out in 21 patients undergoing intraoperative brain mapping prior to tumor resection. The left ventrolateral premotor cortex (vlPM-BA6) was identified preoperatively by functional magnetic resonance imaging, and then investigated intraoperatively using high frequency direct electrical stimulation (HF-DES) of the convexity of M1 and vlPM-BA6, with simultaneous recording of motor-evoked potentials (MEPs) from oro-facial, hand and arm muscles...
December 5, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27916131/synthesis-of-nano-hydroxyapatite-sorbent-for-microextraction-in-packed-syringe-of-phthalate-esters-in-water-samples
#6
Amirhassan Amiri, Mohammad Chahkandi, Azadeh Targhoo
An easy alkoxide-based sol-gel method using Ca(NO3)2·4H2O and tri-ethyl phosphate (PO(OC2H5)3; TEP) precursors employed to synthesize nano-hydroxyapatite (HAP). The structural characterization of samples was studied using XRD, TEM and elemental analysis of SEM. Scherrer and Williamson-Hall equations were applied to measurement of the crystallite size distributions and micro-strain of the synthesized HAP powder. The synthesized HAP nanoparticles were applied as an efficient sorbent for the microextraction in packed syringe (MEPS) of phthalate esters (PAEs) from water samples...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27915482/correlation-between-forced-vital-capacity-and-slow-vital-capacity-for-the-assessment-of-respiratory-involvement-in-amyotrophic-lateral-sclerosis-a-prospective-study
#7
Susana Pinto, Mamede de Carvalho
INTRODUCTION: Slow vital capacity (SVC) and forced vital capacity (FVC) are the most frequent used tests evaluating respiratory function in amyotrophic lateral sclerosis (ALS). No previous study has determined their interchangeability. OBJECTIVE: To evaluate SVC-FVC correlation in ALS. METHODS: Consecutive definite/probable ALS and primary lateral sclerosis (PLS) patients (2000-2014) in whom respiratory tests were performed at baseline/4-6months later were included...
December 4, 2016: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/27911807/enhanced-limonene-production-in-cyanobacteria-reveals-photosynthesis-limitations
#8
Xin Wang, Wei Liu, Changpeng Xin, Yi Zheng, Yanbing Cheng, Su Sun, Runze Li, Xin-Guang Zhu, Susie Y Dai, Peter M Rentzepis, Joshua S Yuan
Terpenes are the major secondary metabolites produced by plants, and have diverse industrial applications as pharmaceuticals, fragrance, solvents, and biofuels. Cyanobacteria are equipped with efficient carbon fixation mechanism, and are ideal cell factories to produce various fuel and chemical products. Past efforts to produce terpenes in photosynthetic organisms have gained only limited success. Here we engineered the cyanobacterium Synechococcus elongatus PCC 7942 to efficiently produce limonene through modeling guided study...
November 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27909072/the-mirror-illusion-increases-motor-cortex-excitability-in-children-with-and-without-hemiparesis
#9
Sebastian Grunt, Christopher J Newman, Stefanie Saxer, Maja Steinlin, Christian Weisstanner, Alain Kaelin-Lang
Background Mirror therapy provides a visual illusion of a normal moving limb by using the mirror reflection of the unaffected arm instead of viewing the paretic limb and is used in rehabilitation to improve hand function. Little is known about the mechanism underlying its effect in children with hemiparesis. Objective To investigate the effect of the mirror illusion (MI) on the excitability of the primary motor cortex (M1) in children and adolescents. Methods Twelve patients with hemiparesis (10-20 years) and 8 typically developing subjects (8-17 years) participated...
November 30, 2016: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/27905930/combinatory-optimization-of-chromosomal-integrated-mevalonate-pathway-for-%C3%AE-carotene-production-in-escherichia-coli
#10
Lijun Ye, Chunzhi Zhang, Changhao Bi, Qingyan Li, Xueli Zhang
BACKGROUND: Plasmid expression is a popular method in studies of MVA pathway for isoprenoid production in Escherichia coli. However, heterologous gene expression with plasmid is often not stable and might burden growth of host cells, decreases cell mass and product yield. In this study, MVA pathway was divided into three modules, and two heterologous modules were integrated into the E. coli chromosome. These modules were individually modulated with regulatory parts to optimize efficiency of the pathway in terms of downstream isoprenoid production...
December 1, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27904798/functional-outcomes-after-distal-biceps-brachii-repair-a-case-series
#11
Christine L Redmond, Tim Morris, Charissa Otto, Tanisha Zerella, John G Semmler, Taaibos Human, Joideep Phadnis, Gregory I Bain
OBJECTIVES: To investigate outcomes after surgical repair of distal biceps tendon rupture and the influence of arm dominance on isokinetic flexion and supination results. BACKGROUND/PURPOSE: While relatively uncommon, rupture of the distal biceps tendon can result in significant strength deficits, for which surgical repair is recommended. The purpose of this study was to assess patient reported functional outcomes and muscle performance following surgery. METHODS: A sample of 23 participants (22 males, 1 female), who had previously undergone surgical repair of the distal biceps tendon, were re-examined at a minimum of one year after surgery...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27902269/description-of-candidatus-marispirochaeta-associata-and-reclassification-of-spirochaeta-bajacaliforniensis-spirochaeta-smaragdinae-and-spirochaeta-sinaica-to-a-new-genus-sediminispirochaeta-gen-nov-as-sediminispirochaeta-bajacaliforniensis-comb-nov-sediminispirochaeta
#12
Shivani Y, Subhash Y, Sasikala Ch, Ramana Ch V
Strain JC231 was isolated from a coastal saline habitat of Gujarat and was identified based on 16S rRNA gene sequence analysis as a member belonging to the genus Spirochaeta and showed highest sequence similarity (<91%) with Spirochaeta bajacaliforniensis DSM 16054T and other members of the family Spirochaetaceae. Intensive attempts to culture strain JC231 in pure culture has failed and was associated with only one species of a Desulfovibrio. However, presence of fosmidomycin inhibited the growth of Desulfovibrio sp...
October 5, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900711/lacertus-fibrosus-augmentation-for-distal-biceps-brachii-rupture-repair-surgical-technique
#13
M Fontana, A Trimarchi, A Colozza
BACKGROUND: Repair of distal biceps tendon ruptures has become widely accepted. Unfortunately, care of retracted-degenerated injuries remains a challenge for orthopedic surgeons. Complication rates appear to increase when surgery is performed in chronic cases compared to those operated acutely. Multiple techniques for chronic reconstruction with the use of grafts have been described. Recently Morrey, from the Mayo Clinic, proposed a direct anatomic repair of retracted distal biceps tendon ruptures in extreme flexion (60°-90°) to avoid grafting...
December 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27900437/bdnf-and-ltp-ltd-like-plasticity-of-the-primary-motor-cortex-in-gilles-de-la-tourette-syndrome
#14
L Marsili, A Suppa, F Di Stasio, D Belvisi, N Upadhyay, I Berardelli, M Pasquini, S Petrucci, M Ginevrino, G Fabbrini, F Cardona, G Defazio, A Berardelli
Gilles de la Tourette syndrome (GTS) is characterized by motor and vocal tics and often associated with obsessive-compulsive disorder (OCD). Responses to intermittent/continuous theta-burst stimulation (iTBS/cTBS), which probe long-term potentiation (LTP)-/depression (LTD)-like plasticity in the primary motor cortex (M1), are reduced in GTS. ITBS-/cTBS-induced M1 plasticity can be affected by brain-derived neurotrophic factor (BDNF) polymorphism. We investigated whether the BDNF polymorphism influences iTBS-/cTBS-induced LTP-/LTD-like M1 plasticity in 50 GTS patients and in 50 age- and sex-matched healthy subjects...
November 30, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27899888/neurophysiological-characterization-of-subacute-stroke-patients-a-longitudinal-study
#15
Giuseppe Lamola, Chiara Fanciullacci, Giada Sgherri, Federica Bertolucci, Alessandro Panarese, Silvestro Micera, Bruno Rossi, Carmelo Chisari
Various degrees of neural reorganization may occur in affected and unaffected hemispheres in the early phase after stroke and several months later. Recent literature suggests to apply a stratification based on lesion location and to consider patients with cortico-subcortical and subcortical strokes separately: different lesion location may also influence therapeutic response. In this study we used a longitudinal approach to perform TMS assessment (Motor Evoked Potentials, MEP, and Silent Period, SP) and clinical evaluations (Barthel Index, Fugl-Meyer Assessment for upper limb motor function and Wolf Motor Function Test) in 10 cortical-subcortical and 10 subcortical ischemic stroke patients...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27898855/genomewide-association-study-of-methane-emissions-in-angus-beef-cattle-with-validation-in-dairy-cattle
#16
C I V Manzanilla-Pech, Y De Haas, B J Hayes, R F Veerkamp, M Khansefid, K A Donoghue, P F Arthur, J E Pryce
Methane (CH) is a product of enteric fermentation in ruminants, and it represents around 17% of global CH emissions. There has been substantial effort from the livestock scientific community toward tools that can help reduce this percentage. One approach is to select for lower emitting animals. To achieve this, accurate genetic parameters and identification of the genomic basis of CH traits are required. Therefore, the objectives of this study were 1) to perform a genomewide association study to identify SNP associated with several CH traits in Angus beef cattle (1,020 animals) and validate them in a lactating Holstein population (population 1 [POP1]; 205 animals); 2) to validate significant SNP for DMI and weight at test (WT) from a second Holstein population, from a previous study (population 2 [POP2]; 903 animals), in an Angus population; and 3) to evaluate 2 different residual CH traits and determine if the genes associated with CH also control residual CH traits...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896358/emergence-of-ordered-network-mesophases-in-kinetic-pathways-of-order-order-transition-for-linear-abc-triblock-terpolymers
#17
Tongjie Sun, Ping Tang, Feng Qiu, An-Chang Shi
Applying the string method to the self-consistent field theory (SCFT) of ABC linear triblock copolymers, we developed a new strategy to design kinetic pathways for the formation of stable or metastable network mesophases in order-order transition (OOT) processes. The design principle regarding the kinetic pathways between distinct mesophases is based on the matching relationships of both domain spacing and dominant Fourier components of the density distributions. The results suggest that complex ordered network mesophases, such as alternating diamond (D(A)) and alternating plumber's nightmare (P(A)) could be obtained in kinetic pathways between simple phases covering lamellae, cylinders and spheres...
November 29, 2016: Soft Matter
https://www.readbyqxmd.com/read/27891607/cortical-and-reticular-contributions-to-human-precision-and-power-grip
#18
Toshiki Tazoe, Monica A Perez
It is well accepted that the corticospinal tract contributes to the control of finger muscles during precision and power grip in humans but the neural mechanisms involved remain poorly understood. Here, we examined motor evoked potentials elicited by cortical and subcortical stimulation of corticospinal axons (MEPs and CMEPs, respectively) and the activity in intracortical circuits (suppression of voluntary electromyography) and spinal motoneurons (F-waves) in an intrinsic hand muscle during index finger abduction (control task), precision grip, and power grip...
November 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27888026/temporary-removal-priming-theta-burst-stimulation-enhances-motor-cortex-plasticity-in-young-but-not-old-adults
#19
George M Opie, Eleni Vosnakis, Michael C Ridding, Ulf Ziemann, John G Semmler
No abstract text is available yet for this article.
November 17, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27886649/spectroscopic-investigation-vibrational-assignments-homo-lumo-nbo-mep-analysis-and-molecular-docking-studies-of-oxoaporphine-alkaloid-liriodenine
#20
Renyer A Costa, Priscilla Olliveira Pitt, Maria Lucia B Pinheiro, Kelson M T Oliveira, Kahlil Schwanka Salomé, Andersson Barison, Emmanoel Vilaça Costa
A combined experimental and theoretical DFT study of the structural, vibrational and electronic properties of liriodenine is presented using B3LYP function with 6-311G (2d, p) basis set. The theoretical geometry optimization data were compared with the X-ray data for a similar structure in the associated literature, showing similar values. In addition, natural bond orbitals (NBOs), HOMO-LUMO energy gap, mapped molecular Electrostatic Potential (MEP) surface calculation, first and second order hyperpolarizabilities were also performed with the same calculation level...
November 16, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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