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https://www.readbyqxmd.com/read/29677095/milling-the-mistletoe-nanotechnological-conversion-of-african-mistletoe-loranthus-micranthus-intoantimicrobial-materials
#1
Muhammad Sarfraz, Sharoon Griffin, Tamara Gabour Sad, Rama Alhasan, Muhammad Jawad Nasim, Muhammad Irfan Masood, Karl Herbert Schäfer, Chukwunonso E C C Ejike, Cornelia M Keck, Claus Jacob, Azubuike P Ebokaiwe
Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and high-pressure homogenization techniques. The milled nanoparticles were characterized using laser diffraction analysis, photon correlation spectroscopy analysis, and light microscopy. The average size of leaf nanoparticles was around 245 nm and that of stem nanoparticles was around 180 nm...
April 20, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29674827/the-effect-of-different-geometric-shapes-and-angles-on-the-fracture-strength-of-ips-e-max-computer-aided-designed-ceramic-onlays-an-in-vitro-study
#2
Jonathan Chu, Vincent Bennani, John M Aarts, Nicholas Chandler, Bronwyn Lowe
Statement of Problem: The current ceramic onlay preparation techniques for cuspal areas involve the reduction of cusps following the cuspal anatomy and the removal of all sharp angulations. However, there is little research literature studying the effect of occlusal preparation angles. Furthermore, there is no recent literature on the effect of angulations on IPS e.max computer-aided designed (CAD) (e.max) ceramic onlays. Purpose: The purpose of this study is to investigate the effect of geometric cuspal angulation and different internal preparation angles on the fracture strength of e...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29673906/interest-of-next-generation-sequencing-in-bcg-treated-high-risk-bladder-cancer
#3
C Jungels, N Martinez Chanza, S Albisinni, M Mercier, N d'Haene, S Rorive, T Roumeguère
OBJECTIVES: There are only few predictive factors for response of non-musculo-invasive bladder cancer (NMIBC) to Bacillus Calmette-Guérin (BCG) therapy. Our study analyzed the results of the sequencing of new generation (NGS) targeted on 50 genes of oncological interest obtained on bladder resection parts in high-risk NMIBC patients treated with BCG, to describe this population from a molecular point of view and try to correlate these results in patients who present or not recurrence after BCG...
April 16, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29673511/coronary-sinus-reducer-implantation-for-the-treatment-of-chronic-refractory-angina-a-single-center-experience
#4
Francesco Giannini, Luca Baldetti, Francesco Ponticelli, Neil Ruparelia, Satoru Mitomo, Azeem Latib, Matteo Montorfano, Richard J Jabbour, Andrea Aurelio, Luca Ferri, Antonio Mangieri, Damiano Regazzoli, Marco Ancona, Matteo Pagnesi, Alessia Faccini, Alaide Chieffo, Lorenzo Azzalini, Mauro Carlino, Antonio Colombo
OBJECTIVES: The aim of this study was to assess the safety and efficacy of the Reducer in a real-world cohort of patients presenting with refractory angina. BACKGROUND: The coronary sinus Reducer is a novel device to aid in the management of patients with severe angina symptoms refractory to optimal medical therapy and not amenable to further revascularization. METHODS: Fifty patients with refractory angina and objective evidence of myocardial ischemia who were judged unsuitable for revascularization were treated with coronary sinus Reducer implantation at a single center between March 2015 and August 2016...
April 23, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29673367/comparing-the-importance-of-quality-measurement-themes-in-juvenile-idiopathic-inflammatory-myositis-between-patients-and-families-and-healthcare-professionals
#5
Heather O Tory, Ruy Carrasco, Thomas Griffin, Adam M Huber, Philip Kahn, Angela Byun Robinson, David Zurakowski, Susan Kim
BACKGROUND: A standardized set of quality measures for juvenile idiopathic inflammatory myopathies (JIIM) is not in use. Discordance has been shown between the importance ascribed to quality measures between patients and families and physicians. The objective of this study was to assess and compare the importance of various aspects of high quality care to patients with JIIM and their families with healthcare providers, to aid in future development of comprehensive quality measures. METHODS: Surveys were developed by members of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Juvenile Dermatomyositis Workgroup through a consensus process and administered to patients and families through the CureJM Foundation and to healthcare professionals through CARRA...
April 19, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29672666/mediators-of-behavior-change-maintenance-in-physical-activity-interventions-for-young-and-middle-aged-adults-a-systematic-review
#6
Jennifer M Murray, Sarah F Brennan, David P French, Christopher C Patterson, Frank Kee, Ruth F Hunter
Background: Regular physical activity is important for maintaining physical and mental health. Benefits are optimized when physical activity is maintained. Understanding causal mechanisms is important to inform future interventions. Purpose: To investigate mediators of physical activity maintenance. Methods: Six databases were searched (Medline, EMBASE, PsycINFO, CINAHL, Cochrane Database of Systematic Reviews, and Web of Science). Eligibility criteria included adult nonclinical populations, validated measure of physical activity behavior at baseline and at least 6 months postbaseline, control/comparison group(s), and reported mediators of physical activity behavior change...
April 17, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29672045/a-comprehensive-scope-of-peripheral-and-axial-substituent-effect-on-the-spectroelectrochemistry-of-boron-subphthalocyanines
#7
Kathleen L Sampson, Xiaoqin Jiang, Esmeralda Bukuroshi, Aleksa Dovijarski, Hasan Raboui, Timothy P Bender, Karl M Kadish
An extensive study of the electrochemical and spectroelectrochemical properties of 14 boron subphthalocyanine (BsubPc) derivatives with various axial and peripheral substituents was performed in 1,2-dichloromethane (CH2Cl2) containing 0.1 M tetra-n-butyl-ammonium perchlorate (TBAP) as the supporting electrolyte. From the cyclic voltammetry results, all compounds exhibit one oxidation and at least two reduction processes within the solvent potential window of +1.6 to -1.8 V vs. SCE. It was found that the reversibility of the redox reactions depends on the axial and peripheral substituents and the dipole moment of the boron-to-axial substituent...
April 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29665501/generation-of-an-integration-free-ipsc-line-cscri005-a-from-erythroid-progenitor-cells-of-a-healthy-indian-male-individual
#8
Kannan V Manian, Sumitha P Bharathan, Madhavi Maddali, Vivi M Srivastava, Alok Srivastava, Shaji Ramachandran Velayudhan
Reprogramming of somatic cells with higher genome integrity, and use of non-integrating gene delivery methods and xeno-free cell culture conditions aid in the generation of iPSCs which are more suitable for disease modelling and clinical applications. We describe here an iPSC line generated using such conditions, which expressed all the pluripotency markers, retained normal karyotype and exhibited the potential for tri-lineage differentiation, both in-vitro and in-vivo. This is the first iPSC line available from a healthy Indian individual for researchers...
April 3, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29663815/canakinumab-as-monotherapy-for-treatment-of-familial-mediterranean-fever-first-report-in-central-and-eastern-europe-region
#9
M Jesenak, K Hrubiskova, L Kapustova, M Kostkova, P Banovcin
Autoinflammatory disorders (AID) are characterized by spontaneous attacks of acute inflammation with a broad spectrum of clinical symptoms. Ongoing inflammation and reoccurrence of acute flares can lead to the development of amyloidosis. One group of AID is represented by monogenic periodic fever syndromes while familial Mediterranean fever (FMF) is the most common form of AID from this group. Its prevalence in Central and Eastern Europe was reported to be very low. We report a case of FMF patient with a very severe clinical course of FMF and intolerance to colchicine, which is a gold standard for FMF treatment...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29661380/relationship-between-severe-obesity-and-depth-to-the-cricothyroid-membrane-in-third-trimester-non-labouring-parturients-a-prospective-observational-study
#10
K Gadd, K Wills, R Harle, N Terblanche
BACKGROUND: Severely obese parturients have increased 'cannot intubate, cannot oxygenate' risk during Caesarean section under general anaesthesia. Front-of-neck access (FONA) at the cricothyroid membrane (CTM) is definitive management; however, attempted FONA can fail. Point-of-care ultrasonography may provide useful information about CTM depth to aid FONA in obesity. This study determined the difference in CTM depth between severely obese and non-obese parturients, utilising ultrasonography...
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29660298/postpartum-hemorrhage-new-insights-for-definition-and-diagnosis
#11
A Borovac-Pinheiro, R C Pacagnella, J G Cecatti, S Miller, A M El Ayadi, J P Souza, J Durocher, P D Blumenthal, B Winikoff
The current definition of postpartum hemorrhage (PPH) is inadequate for early recognition of this important cause of maternal mortality, responsible for more than 80,000 deaths worldwide in 2015. A stronger definition of PPH should include both blood loss and clinical signs of cardiovascular changes after delivery, which would help providers to more promptly and accurately identify PPH. Along with the amount of blood loss, clinical signs and specifically the Shock Index (heart rate divided by systolic blood pressure) appear to aid in more accurate diagnosis of PPH...
April 13, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29659155/breaking-with-tradition-a-scoping-meta-analysis-analyzing-the-effects-of-student-centered-learning-and-computer-aided-instruction-on-student-performance-in-anatomy
#12
Adam B Wilson, Kirsten M Brown, Jonathan Misch, Corinne H Miller, Barbie A Klein, Melissa A Taylor, Michael Goodwin, Eve K Boyle, Chantal Hoppe, Michelle D Lazarus
While prior meta-analyses in anatomy education have explored the effects of laboratory pedagogies and histology media on learner performance, the effects of student-centered learning (SCL) and computer-aided instruction (CAI) have not been broadly evaluated. This research sought to answer the question, "How effective are student-centered pedagogies and CAI at increasing student knowledge gains in anatomy compared to traditional didactic approaches?" Relevant studies published within the past 51 years were searched using five databases...
April 16, 2018: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29658147/vertical-movement-symmetry-of-the-withers-in-horses-with-induced-forelimb-and-hindlimb-lameness-at-trot
#13
M Rhodin, E Persson-Sjodin, A Egenvall, F M Serra Bragança, T Pfau, L Roepstorff, M A Weishaupt, M H Thomsen, P R van Weeren, E Hernlund
BACKGROUND: The main criteria for lameness assessment in horses are head movement for forelimb lameness and pelvic movement for hindlimb lameness. However, compensatory head nod in horses with primary hindlimb lameness is a well-known phenomenon. This compensatory head nod movement can be easily misinterpreted as a sign of primary ipsilateral forelimb lameness. Therefore, discriminating compensatory asymmetries from primary directly pain-related movement asymmetries is a prerequisite for successful lameness assessment...
April 15, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29658143/which-very-elderly-diffuse-large-b-cell-lymphoma-patients-can-benefit-from-curative-treatment-a-multicenter-retrospective-analysis-by-the-spanish-geltamo-group
#14
Emilia Pardal, Eva Díez Baeza, Queralt Salas, Tomás García, Juan M Sancho, Encarna Monzón, José M Moraleda, Raúl Córdoba, Fátima de la Cruz, José A Queizán, María J Rodríguez, Belén Navarro, José A Hernández, Rosana Díez, María Vahi, María C Viguria, Miguel Canales, María J Peñarrubia, Tomás J González-López, Santiago Montes-Moreno, Eva González-Barca, Dolores Caballero, Alejandro Martín
The means of optimally managing very elderly patients with diffuse large B-cell lymphoma (DLBCL) has not been established. We retrospectively analyzed 252 patients aged 80-100 years, diagnosed with DLBCL or grade 3B follicular lymphoma, treated in 19 hospitals from the GELTAMO group. Primary objective was to analyze the influence of the type of treatment and comorbidity scales on progression-free survival (PFS) and overall survival (OS). 163 patients (63%) were treated with chemotherapy that included anthracyclines and/or rituximab, whereas 15% received no chemotherapeutic treatment...
April 15, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29655927/interruptions-experienced-by-emergency-nurses-implications-for-subjective-and-objective-measures-of-workload
#15
Katherine L Forsyth, Hunter J Hawthorne, Nibras El-Sherif, Rachelen S Varghese, Vickie K Ernste, Jordyn Koenig, Renaldo C Blocker
INTRODUCTION: This study aimed to describe interruptions experienced by emergency nurses and establish convergence validity of 1 objective workload measure by linking interruption characteristics to objective and subjective measures of workload. METHODS: Interruptions were captured in real time across 8- or 12-hour shifts using a previously validated Workflow Interruptions Tool (WIT). Data collected on each interruption included type, priority, and location where the interruption occurred...
April 11, 2018: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/29651922/prior-exposure-to-intimate-partner-violence-associated-with-less-hiv-testing-among-young-women
#16
Yukiko Washio, Elizabeth Novack Wright, Annet Davis-Vogel, Jesse Chittams, Claire Anagnostopulos, Linda M Kilby, Anne M Teitelman
Low-income minority women are disproportionately represented among those living with HIV in the United States. They are also at risk for the SAVA (substance abuse, violence, and HIV/AIDS) syndemic issues. Women who have recently given birth are at high risk for substance use and intimate partner violence (IPV), and HIV testing is not routinely administered during the postpartum visit. We explored the relationship between substance use, IPV, and HIV testing among low-income young adult women attending Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), a federally supported nutrition program...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29651763/computer-aided-diagnosis-prior-to-conventional-interpretation-of-prostate-mpmri-an-international-multi-reader-study
#17
Matthew D Greer, Nathan Lay, Joanna H Shih, Tristan Barrett, Leonardo Kayat Bittencourt, Samuel Borofsky, Ismail Kabakus, Yan Mee Law, Jamie Marko, Haytham Shebel, Francesca V Mertan, Maria J Merino, Bradford J Wood, Peter A Pinto, Ronald M Summers, Peter L Choyke, Baris Turkbey
OBJECTIVES: To evaluate if computer-aided diagnosis (CAD) prior to prostate multi-parametric MRI (mpMRI) can improve sensitivity and agreement between radiologists. METHODS: Nine radiologists (three each high, intermediate, low experience) from eight institutions participated. A total of 163 patients with 3-T mpMRI from 4/2012 to 6/2015 were included: 110 cancer patients with prostatectomy after mpMRI, 53 patients with no lesions on mpMRI and negative TRUS-guided biopsy...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29651117/field-validation-of-recombinant-antigen-immunoassays-for-diagnosis-of-lassa-fever
#18
Matthew L Boisen, Jessica N Hartnett, Jeffrey G Shaffer, Augustine Goba, Mambu Momoh, John Demby Sandi, Mohamed Fullah, Diana K S Nelson, Duane J Bush, Megan M Rowland, Megan L Heinrich, Anatoliy P Koval, Robert W Cross, Kayla G Barnes, Anna E Lachenauer, Aaron E Lin, Mahan Nekoui, Dylan Kotliar, Sarah M Winnicki, Katherine J Siddle, Michael Gbakie, Mbalu Fonnie, Veronica J Koroma, Lansana Kanneh, Peter C Kulakosky, Kathryn M Hastie, Russell B Wilson, Kristian G Andersen, Onikepe O Folarin, Christian T Happi, Pardis C Sabeti, Thomas W Geisbert, Erica Ollmann Saphire, S Humarr Khan, Donald S Grant, John S Schieffelin, Luis M Branco, Robert F Garry
Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a patient's clinical presentation. The field performance of recombinant antigen-based Lassa fever immunoassays was compared to that of quantitative polymerase chain assays (qPCRs) using samples from subjects meeting the case definition of Lassa fever presenting to Kenema Government Hospital in Sierra Leone. The recombinant Lassa virus (ReLASV) enzyme-linked immunosorbant assay (ELISA) for detection of viral antigen in blood performed with 95% sensitivity and 97% specificity using a diagnostic standard that combined results of the immunoassays and qPCR...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29648600/comparison-of-two-alternate-pgf2%C3%AE-products-in-two-estrus-synchronization-protocols-in-beef-heifers
#19
Nicola Oosthuizen, Alicia C Lansford, Luara B Canal, Pedro L P Fontes, Carla D Sanford, Carl R Dahlen, Nicolas DiLorenzo, Rick N Funston, G Cliff Lamb
Two experiments were conducted to evaluate the effects of a high concentrate, s.c. PGF2α compared with a conventionally concentrated, i.m. PGF2α in estrus synchronization protocols for heifers. In Exp. 1, 869 Angus-based beef heifers were enrolled at 8 locations. All heifers were exposed to the 7-d CO-Synch + controlled internal drug release (CIDR) estrus synchronization protocol. On day 7 of the protocol heifers received 100 µg of GnRH i.m., and a CIDR insert for 7 d. On day 0, at CIDR removal, estrous detection patches were applied to heifers and, within location, heifers randomly received 1 of 2 PGF2α treatments: 5 mL of Lutalyse i...
April 10, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29645080/risk-of-oral-tongue-cancer-among-immunocompromised-transplant-recipients-and-human-immunodeficiency-virus-infected-individuals-in-the-united-states
#20
Joseph E Tota, Eric A Engels, Margaret M Madeleine, Christina A Clarke, Charles F Lynch, Ana P Ortiz, Brenda Y Hernandez, Anil K Chaturvedi
BACKGROUND: Oral tongue cancer incidence has increased among whites in the United States; however, the cause remains unknown. If an infectious agent is implicated, then elevated risk would be expected among immunosuppressed individuals. METHODS: By using population-based registry linkage information from the US Transplant Cancer Match and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) Cancer Match studies, the authors examined the risk of oral tongue squamous cell carcinoma (SCC) among immunocompromised transplantation recipients and HIV-infected individuals...
April 12, 2018: Cancer
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