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https://www.readbyqxmd.com/read/29914478/community-understanding-of-the-concept-of-pre-referral-treatment-and-how-this-impacts-on-referral-related-decision-making-following-the-provision-of-rectal-artesunate-a-qualitative-study-in-western-uganda
#1
C E Strachan, A Nuwa, D Muhangi, A P Okui, M E H Helinski, J K Tibenderana
BACKGROUND: Successful pre-referral treatment with rectal artesunate (RA) for suspected severe malaria requires operational linkages between community health workers (CHWs) and referral facilities, acceptance of pre-referral treatment and adherence to referral practices by CHWs and caregivers. This qualitative study investigated how community understanding of the concept of 'pre-referral treatment' is used in referral related decision-making following provision of RA in Uganda. METHODS: Narrative interviews were conducted with 30 caregivers of children under five who received RA within the previous three months and the 30 associated CHWs who provided the treatment...
June 19, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29912859/energetics-of-swimming-with-hand-paddles-of-different-surface-areas
#2
George H Crocker, Joseph F Moon, Jeff A Nessler, Sean C Newcomer
Crocker, GH, Moon, JF, Nessler, JA, and Newcomer, SC. Energetics of swimming with hand paddles of different surface areas. J Strength Cond Res XX(X): 000-000, 2018-Hand paddles are one of the most common training aids used by the competitive swimmer, yet little is known regarding how hand paddle surface area affects the metabolic cost of transport (COT) while swimming. The purpose of this study was to determine how altering hand paddle size affects energy use during submaximal, front-crawl (i.e., freestyle) swimming...
June 15, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29911947/oral-and-dental-anomalies-in-purebred-brachycephalic-persian-and-exotic-cats
#3
Lisa A Mestrinho, João M Louro, Iněs S Gordo, Maria M R E Niza, João F Requicha, Judith G Force, Jerzy P Gawor
OBJECTIVE To determine the prevalence of dental anomalies in brachycephalic cats from various geographic regions and analyze potential relationships with oral disease. DESIGN Prospective multicenter cross-sectional study. ANIMALS 50 purebred Persian (n = 42) and Exotic (8) cats. PROCEDURES Cats were anesthetized, and a complete dental examination, dental charting, 3-view oral photography, and full-mouth dental radiography were performed. RESULTS Malocclusions were observed in 36 (72%) cats. Crowding of the teeth was evident in 28 (56%) cats, with the incisors being most commonly affected...
July 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29911400/periprocedural-outcome-after-laparoscopic-partial-nephrectomy-versus-radiofrequency-ablation-for-t1-renal-tumors-a-modified-r-e-n-a-l-nephrometry-score-adjusted-comparison
#4
Vanessa Acosta Ruiz, Sam Ladjevardi, Einar Brekkan, Michael Häggman, Maria Lönnemark, Lisa Wernroth, Anders Magnusson
Background Comparable oncological outcomes have been seen after surgical nephrectomy and thermal ablation of renal tumors recently. However, periprocedural outcome needs to be assessed for aiding treatment decision. Purpose To compare efficacy rates and periprocedural outcome (technical success, session time, hospitalization time, and complications) after renal tumor treatment with laparoscopic partial nephrectomy (LPN) or radiofrequency ablation (RFA). Material and Methods The initial experience with 49 (treated with LPN) and 84 (treated with RFA) consecutive patients for a single renal tumor (diameter ≤ 5 cm, limited to the kidney) during 2007-2014 was evaluated...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29910717/mental-state-assessment-and-validation-using-personalized-physiological-biometrics
#5
Aashish N Patel, Michael D Howard, Shane M Roach, Aaron P Jones, Natalie B Bryant, Charles S H Robinson, Vincent P Clark, Praveen K Pilly
Mental state monitoring is a critical component of current and future human-machine interfaces, including semi-autonomous driving and flying, air traffic control, decision aids, training systems, and will soon be integrated into ubiquitous products like cell phones and laptops. Current mental state assessment approaches supply quantitative measures, but their only frame of reference is generic population-level ranges. What is needed are physiological biometrics that are validated in the context of task performance of individuals...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29910522/zombie-ant-fungi-across-continents-15-new-species-and-new-combinations-within-ophiocordyceps-i-myrmecophilous-hirsutelloid-species
#6
J P M Araújo, H C Evans, R Kepler, D P Hughes
Ophiocordyceps species infecting ants - the so-called zombie-ant fungi - comprise one of the most intriguing and fascinating relationships between microbes and animals. They are widespread within tropical forests worldwide, with relatively few reports from temperate ecosystems. These pathogens possess the ability to manipulate host behaviour in order to increase their own fitness. Depending on the fungal species involved the infected ants are manipulated either to leave the nest to ascend understorey shrubs, to die biting onto vegetation, or descend from the canopy to die at the base of trees...
June 2018: Studies in Mycology
https://www.readbyqxmd.com/read/29905089/thyroid-cancer-treatment-choice-a-pilot-study-of-a-tool-to-facilitate-conversations-with-patients-with-papillary-microcarcinomas-considering-treatment-options
#7
Juan P Brito, Jae Hoon Moon, Rebecca Zeuren, Sung Hye Kong, Yeo Koon Kim, Nicole M Iñiguez-Ariza, June Young Choi, Kyu Eun Lee, Ji-Hoon Kim, Ian Hargraves, Victor Bernet, Victor Montori, Young Joo Park, R Michael Tuttle
BACKGROUND: The 2015 American Thyroid Association guidelines recognize active surveillance as an alternative to immediate surgery in patients with papillary microcarcinomas (PMCs). As a way to incorporate active surveillance as one of the management options for patients with PMCs, we describe the development and initial testing of a tool to support conversations between clinicians and patients with PMCs considering treatment options. METHODS: Thyroid Cancer Treatment Choice was developed using an iterative process based on the principles of interaction, design and participatory action research...
June 15, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29904986/factors-associated-with-patient-involvement-in-emergency-care-decisions-a-secondary-analysis-of-the-chest-pain-choice-multicenter-randomized-trial
#8
Marc A Probst, Craig F Tschatscher, Christine M Lohse, M Fernanda Bellolio, Erik P Hess
BACKGROUND: Shared decision-making in the Emergency Department (ED) can increase patient engagement for patients presenting with chest pain. However, little is known regarding which factors are associated with actual patient involvement in decision-making or patients' desired involvement in emergency care decisions. We examined which factors were associated with patients' actual and desired involvement in decision-making among ED chest pain patients. METHODS: This is a secondary analysis of data from a randomized trial of a shared decision-making intervention in ED patients with low-risk chest pain...
June 15, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29904641/electrophysiological-evidence-for-the-interaction-of-prosody-and-thematic-fit-during-sentence-comprehension
#9
Shannon M Sheppard, Katherine J Midgley, Tracy Love, Lewis P Shapiro, Phillip J Holcomb
This study investigated the interaction of prosody and thematic fit/plausibility information during the processing of sentences containing temporary early closure (correct) or late closure (incorrect) syntactic ambiguities using event-related potentials (ERPs). Early closure sentences with congruent and incongruent prosody were presented where the temporarily ambiguous NP was either a plausible or an implausible continuation for the subordinate verb (e.g. "While the band played the song/beer pleased all the customers...
2018: Language, Cognition and Neuroscience
https://www.readbyqxmd.com/read/29903762/the-egvhd-app-has-the-potential-to-improve-the-accuracy-of-graft-versus-host-disease-assessment-a-multicenter-randomized-controlled-trial
#10
Helene M Schoemans, Kathy Goris, Raf Van Durm, Steffen Fieuws, Sabina De Geest, Steven Z Pavletic, Annie Im, Daniel Wolff, Stephanie J Lee, Hildegard Greinix, Rafael F Duarte, Xavier Poiré, Dominik Selleslag, Philippe Lewalle, Tessa Kerre, Carlos Graux, Frédéric Baron, Johan A Maertens, Fabienne Dobbels
Graft-versus-host disease assessment has been shown to be a challenge for healthcare professionals, leading to the development of the eGVHD App (www.uzleuven.be/egvhd). In this study, we formally evaluated the accuracy of using the App compared to traditional assessment methods to assess graft-versus-host disease. Our national multicenter randomized controlled trial involved seven Belgian transplantation centers and 78 healthcare professionals selected using a two-stage convenience sampling approach between January and April 2017...
June 14, 2018: Haematologica
https://www.readbyqxmd.com/read/29902683/anthropometric-and-body-composition-changes-in-smokers-vs-abstainers-following-an-exercise-aided-pharmacotherapy-smoking-cessation-trial-for-women
#11
Harry Prapavessis, Stefanie De Jesus, Lyndsay Fitzgeorge, Scott Rollo
INTRODUCTION: Post-cessation weight gain contributes to smoking relapse, especially for women. Furthermore, excess weight in the form of android or visceral fat is associated with metabolic health problems. For this study, a secondary analysis was conducted in 2015 to determine whether quitting status, achieved through a 14 week supervised exercise-aided nicotine replacement therapy (NRT) cessation program [Getting Physical on Cigarette Trial-2009 to 2013; Prapavessis, et al., 2016], affects anthropometric and body composition parameters in female smokers (N = 413, M age = 42...
June 7, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29902377/occurrence-of-legionella-spp-in-water-main-biofilms-from-two-drinking-water-distribution-systems
#12
Michael Waak, Timothy M LaPara, Cynthia Halle, Raymond M Hozalski
The maintenance of a chlorine or chloramine residual to suppress waterborne pathogens in drinking water distribution systems is common practice in the United States but less common in Europe. In this study, we investigated the occurrence of Bacteria and Legionella spp. in water-main biofilms and tap water from a chloraminated distribution system in the United States and a system in Norway with no residual using real-time quantitative polymerase chain reaction (qPCR). Despite generally higher temperatures and assimilable organic carbon levels in the chloraminated system, total Bacteria and Legionella spp...
June 14, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29902295/association-of-erbb-mutations-with-clinical-outcomes-of-afatinib-or-erlotinib-treated-patients-with-lung-squamous-cell-carcinoma-secondary-analysis-of-the-lux-lung-8-randomized-clinical-trial
#13
Glenwood D Goss, Enriqueta Felip, Manuel Cobo, Shun Lu, Konstantinos Syrigos, Ki Hyeong Lee, Erdem Göker, Vassilis Georgoulias, Wei Li, Salih Guclu, Dolores Isla, Young Joo Min, Alessandro Morabito, Andrea Ardizzoni, Shirish M Gadgeel, Andrea Fülöp, Claudia Bühnemann, Neil Gibson, Nicole Krämer, Flavio Solca, Agnieszka Cseh, Eva Ehrnrooth, Jean-Charles Soria
Importance: Treatment choice for lung squamous cell carcinoma could be aided by identifying predictive biomarkers. Objective: To assess whether patient outcomes in the LUX-Lung 8 trial were associated with ERBB gene family member aberrations in tumor specimens. Design, Setting, and Participants: Ad hoc secondary analysis of the LUX-Lung 8 trial conducted at 183 centers in 23 countries from March 30, 2012, to January 30, 2014. Eligible patients had stage IIIB or IV lung squamous cell carcinoma with progressive disease after 4 or more cycles of platinum-based chemotherapy...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29902286/association-of-somatic-driver-alterations-with-prognosis-in-postmenopausal-hormone-receptor-positive-her2-negative-early-breast-cancer-a-secondary-analysis-of-the-big-1-98-randomized-clinical-trial
#14
Stephen J Luen, Rebecca Asher, Chee Khoon Lee, Peter Savas, Roswitha Kammler, Patrizia Dell'Orto, Olivia Maria Biasi, David Demanse, Lellean JeBailey, Sinead Dolan, Wolfgang Hackl, Beat Thuerlimann, Giuseppe Viale, Marco Colleoni, Meredith M Regan, Sherene Loi
Importance: A range of somatic driver alterations has been described in estrogen receptor-positive, HER2-negative (ER+/HER2-) early breast cancer (BC); however, the clinical relevance is unknown. Objective: To investigate associations of driver alterations with prognosis and the role of PIK3CA mutations in prediction of benefit associated with endocrine therapy in postmenopausal patients with ER+/HER2- early BC treated with tamoxifen or letrozole. Design, Setting, and Participants: The Breast International Group (BIG) 1-98 trial randomized 8010 postmenopausal patients with hormone receptor-positive, operable, invasive BC to monotherapy with letrozole, tamoxifen, or a sequential strategy for 5 years...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29901853/deep-learning-based-computer-aided-classifier-developed-with-a-small-dataset-of-clinical-images-surpasses-board-certified-dermatologists-in-skin-tumor-diagnosis
#15
Y Fujisawa, Y Otomo, Y Ogata, Y Nakamura, R Fujita, Y Ishitsuka, R Watanabe, N Okiyama, K Ohara, M Fujimoto
BACKGROUND: Application of deep-learning technology to skin cancer classification can potentially improve skin cancer screening sensitivity and specificity, but the number of training images required for such system is thought to be extremely large. OBJECTIVE: To determine if deep-learning technology could be used to develop an efficient skin cancer classifying system with a relatively small dataset of clinical images. METHODS: A deep convolutional neural network (DCNN) was trained using a dataset of 4867 clinical images obtained from 1842 patients diagnosed with skin tumors at the University of Tsukuba Hospital from 2003 to 2016...
June 14, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29901821/risk-of-diabetes-in-hiv-infected-patients-is-associated-with-cirrhosis-but-not-with-chronic-hcv-coinfection-in-a-french-nationwide-hiv-cohort
#16
A Provoost, M Dramé, L Cotte, L Cuzin, R Garraffo, D Rey, F Raffi, I Poizot-Martin, P Pugliese, F Bani-Sadr
BACKGROUND: Both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections have been reportedly associated with a higher risk of diabetes mellitus (DM) but results are conflicting. AIMS: To determine whether there is an association between chronic HCV and the incidence of DM, and to study the role of factors such as cirrhosis, IFN-based HCV therapy, sustained virologic response (SVR) and chronic HBV infection among patients living with HIV (PLHIV) followed in a large French multicentre cohort in the combination antiretroviral therapy (cART) era...
June 14, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29898107/drying-and-reduction-in-sensitivity-to-desiccation-of-seeds-of-alibertia-edulis-the-influence-of-fruit-ripening-stage
#17
Thais Cremon, Daiane M Dresch, Silvana P Q Scalon, Tathiana E Masetto
The intense environmental degradation in tropical regions suitable for agriculture has decreased native forest populations of plants with important fruits and medicinal properties. Alibertia edulis is a native tree from the Brazilian Cerrado. Knowledge about the effects of drying and storage on the physiological behavior of its seeds may aid in its sustainable exploitation and conservation. The goal of the present study was to determine which fruit ripening stage results in A. edulis seeds with higher tolerance to desiccation, and to investigate the effectiveness of polyethylene glycol (PEG) induced osmotic stress in combination with abscisic acid (ABA) in increasing seed desiccation tolerance during storage...
April 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29897428/standardized-end-point-definitions-for-coronary-intervention-trials-the-academic-research-consortium-2-consensus-document
#18
Hector M Garcia-Garcia, Eugène P McFadden, Andrew Farb, Roxana Mehran, Gregg W Stone, John Spertus, Yoshinobu Onuma, Marie-Angèle Morel, Gerrit-Anne van Es, Bram Zuckerman, William F Fearon, David Taggart, Arie-Pieter Kappetein, Mitchell W Krucoff, Pascal Vranckx, Stephan Windecker, Donald Cutlip, Patrick W Serruys
The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bioresorbable vascular scaffolds. In addition, recommendations for the incorporation of patient-related outcomes in clinical trials are proposed. Academic Research Consortium-2 is a collaborative effort between academic research organizations in the United States and Europe, device manufacturers, and European, US, and Asian regulatory bodies...
June 11, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29891620/standardized-end-point-definitions-for-coronary-intervention-trials-the-academic-research-consortium-2-consensus-document
#19
REVIEW
Hector M Garcia-Garcia, Eugène P McFadden, Andrew Farb, Roxana Mehran, Gregg W Stone, John Spertus, Yoshinobu Onuma, Marie-Angèle Morel, Gerrit-Anne van Es, Bram Zuckerman, William F Fearon, David Taggart, Arie-Pieter Kappetein, Mitchell W Krucoff, Pascal Vranckx, Stephan Windecker, Donald Cutlip, Patrick W Serruys
The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bioresorbable vascular scaffolds. In addition, recommendations for the incorporation of patient-related outcomes in clinical trials are proposed. Academic Research Consortium-2 is a collaborative effort between academic research organizations in the United States and Europe, device manufacturers, and European, US, and Asian regulatory bodies...
June 12, 2018: Circulation
https://www.readbyqxmd.com/read/29890429/conception-risk-of-beef-cattle-after-fixed-time-artificial-insemination-using-either-sexedultra%C3%A2-4m-sex-sorted-semen-or-conventional-semen
#20
B R Crites, R Vishwanath, A M Arnett, P J Bridges, W R Burris, K R McLeod, L H Anderson
The objective of this study was to compare conception rates of female beef cattle inseminated at a fixed-time with either conventional (CON) or SexedUltra™ sex-sorted (SU) semen. Treatments included CON or SU with two sires represented within each treatment. Cows (n = 316) and heifers (n = 78) from six locations were randomly assigned treatment. Ovulation was synchronized in all females using the industry-standard 7-d CO-Synch + controlled internal drug release (CIDR) protocol (100 μg GnRH + CIDR [1...
June 6, 2018: Theriogenology
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