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https://www.readbyqxmd.com/read/29905051/-new-type-of-sutured-titanium-wire-combined-with-titanium-nail-internal-fixation-for-correction-of-serious-old-medial-canthus-deformity
#1
Ying Zhang, Changhong Zeng, Jun Chen, Bo Guo
Objective: To evaluate the effectiveness of a new type of sutured titanium wire combined with titanium nail internal fixation in correction of serious old medial canthus deformity. Methods: Between March 2012 and June 2015, 18 patients with unilateral serious old medial canthus deformity were treated. There were 14 males and 4 females. The patient's age ranged from 23 to 62 years (mean, 42 years). The causes of deformity included accident injury in 10 cases, boxing injury in 4 cases, sharp device scratching in 3 cases, and animal bite in 1 case...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29901604/skin-avulsion-injuries-caused-by-the-application-of-adhesive-drapes-during-total-knee-arthroplasty-a-case-report
#2
Bin Yang, Chuanzhi Xiong, Zhihua Lu, Jingcheng Wang
RATIONALE: The use of adhesive drapes has decreased the incidence of surgical-site infections. PATIENT CONCERNS: Despite the obvious benefits of the proper use of drapes, there remain many potential risks. DIAGNOSE: A 66-year-old man with a history of left knee osteoarthritis and varus deformity underwent total knee arthroplasty at our hospital, upon removal of the adhesive drape by delicate peeling and warm saline lavage, a large area of the skin avulsion happened...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900482/chitosan-s-biological-activity-upon-skin-related-microorganisms-and-its-potential-textile-applications
#3
REVIEW
Eduardo M Costa, Sara Silva, Mariana Veiga, Freni K Tavaria, Maria M Pintado
Over the years the body of work relating chitosan and its possible skin-related applications has grown, showing that chitosan is active both as a free compound and as a functional finishing of textiles. As a free molecule chitosan proved itself to be an attractive option as it is biocompatible and has a demonstrated biological activity (e.g. growth inhibition or adhesion inhibition) upon multiple skin pathogens, even upon multidrug resistant species. Furthermore, chitosan has wound healing accelerating properties, which make it a prime candidate for possible control of skin related infections...
June 13, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29897930/loss-of-fnip1-alters-kidney-developmental-transcriptional-program-and-synergizes-with-tsc1-loss-to-promote-mtorc1-activation-and-renal-cyst-formation
#4
Ryan Centini, Mark Tsang, Terri Iwata, Heon Park, Jeffrey Delrow, Daciana Margineantu, Brandon M Iritani, Haiwei Gu, H Denny Liggitt, Janella Kang, Lim Kang, David M Hockenbery, Daniel Raftery, Brian M Iritani
Birt-Hogg-Dube' Syndrome (BHDS) is a rare genetic disorder in humans characterized by skin hamartomas, lung cysts, pneumothorax, and increased risk of renal tumors. BHDS is caused by mutations in the BHD gene, which encodes for Folliculin, a cytoplasmic adapter protein that binds to Folliculin interacting proteins-1 and -2 (Fnip1, Fnip2) as well as the master energy sensor AMP kinase (AMPK). Whereas kidney-specific deletion of the Bhd gene in mice is known to result in polycystic kidney disease (PKD) and renal cell carcinoma, the roles of Fnip1 in renal cell development and function are unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29894820/cd44-dependent-inflammation-fibrogenesis-and-collagenolysis-regulates-extracellular-matrix-remodeling-and-tensile-strength-during-cutaneous-wound-healing
#5
REVIEW
Priya Govindaraju, Leslie Todd, Snehal Shetye, James Monslow, Ellen Puré
Cutaneous wound healing consists of three main phases: inflammation, re-epithelialization, and tissue remodeling. During normal wound healing, these processes are tightly regulated to allow restoration of skin function and biomechanics. In many instances, healing leads to an excess accumulation of fibrillar collagen (the principal protein found in the extracellular matrix - ECM), and the formation of scar tissue, which has compromised biomechanics, tested using ramp to failure tests, compared to normal skin (Corr and Hart, 2013 [1])...
June 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29894790/preparation-and-structural-characterization-of-surface-modified-microporous-bacterial-cellulose-scaffolds-a-potential-material-for-skin-regeneration-applications-in-vitro-and-in-vivo
#6
Shaukat Khan, Mazhar Ul-Islam, Muhammad Ikram, Salman Ul Islam, Muhammad Wajid Ullah, Muhammad Israr, Jae Hyun Jang, Sik Yoon, Joong Kon Park
This study reports the fabrication of porogen-induced, surface-modified, 3-dimensionally microporous regenerated bacterial cellulose (rBC)/gelatin (3DMP rBC/G) scaffolds for skin regeneration applications. Round shaped gelatin microspheres (GMS), fabricated using a water-in-oil emulsion (WOE) method, were utilized as the porogen. The dissolution of GMS from the solution casted BC scaffolds led to surface-modified microporous rBC. The scaffolds were characterized using field emission scanning electron microscopy (FE-SEM) and elemental analysis...
June 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29894409/effectiveness-of-interventions-for-preventing-occupational-irritant-hand-dermatitis-a-quantitative-systematic-review
#7
Zoi Papadatou, Hector Williams, Kay Cooper
OBJECTIVE: The aim of this review was to identify, appraise and synthesize the best available evidence on the effectiveness of moisturizers, barrier creams, protective gloves, skin protection education and complex interventions (a combination of two or more of the interventions listed here) in preventing occupational irritant hand dermatitis (OIHD) in wet workers, comparing each intervention to an alternative intervention or to usual care (workers' regular skin care regimen). INTRODUCTION: The most significant occupational skin problem potentially encountered in wet work occupations is occupational dermatitis...
June 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29889785/first-results-with-a-new-pressure-free-adhesive-bone-conduction-hearing-aid
#8
Valerie Dahm, Wolf-Dieter Baumgartner, Rudolfs Liepins, Christoph Arnoldner, Dominik Riss
OBJECTIVES: The aim of this study was to evaluate the hearing benefit, advantages, and disadvantages in a series of patients using a new, nonimplantable, pressure-free, adhesive bone conduction hearing aid. METHODS: Twelve patients were included in the study at the ear, nose, and throat department of the Medical University of Vienna. All patients suffered from conductive hearing loss for at least 3 months. A sound field audiometry, Freiburg monosyllables word test and Oldenburg sentence test were carried out...
July 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29888507/cd34-stromal-expression-is-inversely-proportional-to-smooth-muscle-actin-expression-and-extent-of-morphea
#9
Ji Su Lee, Hyun-Sun Park, Hyun-Sun Yoon, Jin Ho Chung, Soyun Cho
BACKGROUND: Fibrosis is thought to be the main pathophysiology of scleroderma, and myofibroblasts play the main role in abnormal fibrotic pathologies. Altered distribution of dermal dendritic cells (DDCs) and vascular abnormalities has been reported to relate to the pathogenesis of scleroderma. OBJECTIVE: To investigate fibrotic pathogenesis of morphea (localized scleroderma) by demonstrating the relative expression and distribution of DDCs and myofibroblasts, we performed immunohistochemical stains using several relevant antibodies...
June 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29888412/allergic-contact-dermatitis-caused-by-acrylic-based-medical-dressings-and-adhesives
#10
Lien Mestach, Sara Huygens, An Goossens, Liesbeth Gilissen
BACKGROUND: Acrylates and methacrylates are acrylic resin monomers that are known to induce skin sensitization as a result of their presence in different materials, such as nail cosmetics, dental materials, printing inks, and adhesives. Allergic contact dermatitis resulting from the use of modern wound dressings containing them has only rarely been reported. OBJECTIVES: To describe 2 patients who developed allergic contact dermatitis caused by acrylic-based modern medical dressings and/or adhesives...
June 11, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29887879/a-proposed-molecular-mechanism-for-physical-analgesia-in-chronic-pain
#11
REVIEW
Norio Saito, Rei Shima, Yurika Yamada, Masaru Nagaoka, Etsuro Ito, Tohru Yoshioka
Although pain is indispensable for survival, chronic pain places a heavy burden on humans. As the efficacy of opioid treatment is limited, the development of alternative methods of pain relief without medication is desirable. Recently, we have developed a novel method of physical analgesia using an adhesive "pyramidal thorn patch." When we apply about 3 trials of these patches on the skin of a pain region, the pain region moves toward the spinal cord like a "cutaneous rabbit," and finally, the pain vanishes...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29887858/the-heme-transporter-htsabc-of-group-a-streptococcus-contributes-to-virulence-and-innate-immune-evasion-in-murine-skin-infections
#12
Yingli Song, Xiaolan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu
Group A Streptococcus (GAS) requires iron for growth, and heme is an important source of iron for GAS. Streptococcus heme transporter A (HtsA) is the lipoprotein component of the GAS heme-specific ABC transporter (HtsABC). The objective of this study is to examine the contribution of HtsABC to virulence and host interaction of hypervirulent M1T1 GAS using an isogenic htsA deletion mutant (Δ htsA ). The htsA deletion exhibited a significantly increased survival rate, reduced skin lesion size, and reduced systemic GAS dissemination in comparison to the wild type strain...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29883510/coverage-of-hand-defects-with-exposed-tendons-the-use-of-dermal-regeneration-template
#13
Eitan Melamed, Charles P Melone
Soft tissue defects associated with exposed tendon pose difficult reconstructive problems because of tendon adhesions, poor range of motion, poor cosmetic appearance, and donor site morbidity. Dermal regeneration template is a skin substitute widely used in reconstructive surgery, including the occasional coverage of tendons. However, postoperative functionality of the tendons has not been well documented. We report a case of using dermal regeneration template for soft tissue reconstruction overlying tendons with loss of paratenon in a patient with Dupuytren's contracture...
May 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29877225/thermal-history-dependent-phase-behavior-of-ceramide-molecular-assembly-in-a-uv-curable-acrylic-adhesive-resin
#14
Hiroshi Takahashi, Kenta Takada, Kenichi Nishimura, Ryota Watanabe
The structure and thermal behavior of a synthetic D-erythro-ceramide [NDS], (2S,3R)-2-octadecanoylamino-octadecane-1,3-diol (CER), molecular assembly in a UV-curable acrylic adhesive resin (acResin® ) were investigated by differential scanning calorimetry (DSC), polarized-light microscopy, and X-ray diffraction (XRD). CER in the resin was found to exhibit a thermal-history-dependent polymorphic phase behavior that is similar but not identical to that observed for pure CER. The melting temperatures of the in-resin CER samples were lower than those of pure CER samples...
June 7, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29868571/fabrication-of-circular-obelisk-type-multilayer-microneedles-using-micro-milling-and-spray-deposition
#15
Min Jung Kim, Seok Chan Park, Binod Rizal, Giselle Guanes, Seung-Ki Baek, Jung-Hwan Park, Amy R Betz, Seong-O Choi
In this study we present the fabrication of multilayer microneedles with circular obelisk and beveled-circular obelisk geometries, which have potential applications in implantable drug delivery devices. Micro-milling was adopted as an environmental-friendly and cost-effective way to fabricate primary metal microneedle masters. Polylactic acid (PLA) microneedles with sharp tips were then obtained by micromolding followed by oxygen plasma etching and used for preparing polydimethylsiloxane (PDMS) microneedle molds...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29867967/mouse-dc-sign-cd209a-as-target-for-antigen-delivery-and-adaptive-immunity
#16
Sjoerd T T Schetters, Laura J W Kruijssen, Matheus H W Crommentuijn, Hakan Kalay, Jordi Ochando, Joke M M den Haan, Juan J Garcia-Vallejo, Yvette van Kooyk
The efficacy of vaccination studies aimed at targeting antigens to human DC-SIGN (hDC-SIGN) have been notoriously difficult to study in vivo , as eight dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) homologs have been described in mice. CD209a/SIGNR5 has been coined as the mouse DC-SIGN (mDC-SIGN) ortholog, based on its expression and location in the genome. Nonetheless, which properties of hDC-SIGN are covered by mDC-SIGN is poorly investigated. One of the most important functions of DC-SIGN is the induction of adaptive immunity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29867522/transcriptome-reveals-long-non-coding-rnas-and-mrnas-involved-in-primary-wool-follicle-induction-in-carpet-sheep-fetal-skin
#17
Yangfan Nie, Shaomei Li, XinTing Zheng, Wenshuo Chen, Xueer Li, Zhiwei Liu, Yong Hu, Haisheng Qiao, Quanqing Qi, Quanbang Pei, Danzhuoma Cai, Mei Yu, Chunyan Mou
Murine primary hair follicle induction is driven by the communication between the mesenchyme and epithelium and mostly governed by signaling pathways including wingless-related integration site (WNT), ectodysplasin A receptor (EDAR), bone morphogenetic protein (BMP), and fibroblast growth factor (FGF), as observed in genetically modified mouse models. Sheep skin may serve as a valuable system for hair research owing to the co-existence of sweat glands with wool follicles in trunk skin and asynchronized wool follicle growth pattern similar to that of human head hair follicles...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29866844/bp180-dysfunction-triggers-spontaneous-skin-inflammation-in-mice
#18
Yang Zhang, Bin-Jin Hwang, Zhen Liu, Ning Li, Kendall Lough, Scott E Williams, Jinbo Chen, Susan W Burette, Luis A Diaz, Maureen A Su, Shengxiang Xiao, Zhi Liu
BP180, also known as collagen XVII, is a hemidesmosomal component and plays a key role in maintaining skin dermal/epidermal adhesion. Dysfunction of BP180, either through genetic mutations in junctional epidermolysis bullosa (JEB) or autoantibody insult in bullous pemphigoid (BP), leads to subepidermal blistering accompanied by skin inflammation. However, whether BP180 is involved in skin inflammation remains unknown. To address this question, we generated a BP180-dysfunctional mouse strain and found that mice lacking functional BP180 (termed Δ NC16A ) developed spontaneous skin inflammatory disease, characterized by severe itch, defective skin barrier, infiltrating immune cells, elevated serum IgE levels, and increased expression of thymic stromal lymphopoietin (TSLP)...
June 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29866230/leukocyte-adhesion-deficiency-type-1-with-low-expression-of-cd-11b
#19
Muhammad Mukarram Bashir, Muhammad Hussain, Dawood Ahmad, Hamid Nawaz Tipu
Leukocyte adhesion deficiency type 1 (LAD-1) is a rare autosomal recessive disorder caused by mutations in the gene that codes for CD18, the beta chain of beta-2 integrins, located on the long arm of chromosome 21. This defect results in failure of leukocyte migration to the site of infection due to the absence of surface integrins. Leukocyte adhesion deficiency should be suspected in any patient with recurrent infections, impaired wound healing, history of delayed umbilical cord separation, periodontitis, leukocytosis, recurrent soft tissue and oral infections...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29863322/highly-stretchable-and-biocompatible-strain-sensors-based-on-mussel-inspired-super-adhesive-self-healing-hydrogels-for-human-motion-monitoring
#20
Xin Jing, Hao-Yang Mi, Yu-Jyun Lin, Eduardo Enriquez, Xiang-Fang Peng, Lih-Sheng Turng
Integrating multifunctionality such as adhesiveness, stretchability, and self-healing ability on a single hydrogel has been a challenge and is a highly desired development for various applications including electronic skin, wound dressings, and wearable devices. In this study, a novel hydrogel was synthesized by incorporating polydopamine-coated talc (PDA-talc) nanoflakes into a polyacrylamide (PAM) hydrogel inspired by the natural mussel adhesive mechanism. Dopamine molecules were intercalated into talc and oxidized, which enhanced the dispersion of talc and preserved catechol groups in the hydrogel...
June 4, 2018: ACS Applied Materials & Interfaces
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