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https://www.readbyqxmd.com/read/29672240/national-survey-of-operating-room-nurses-aseptic-techniques-and-interventions-for-patient-preparation-to-reduce-surgical-site-infections
#1
Camilla Wistrand, Karin Falk-Brynhildsen, Ulrica Nilsson
BACKGROUND: Surgical site infection (SSI), the third most common type of nosocomial infection in Sweden, is a patient injury that should be prevented. Methods of reducing SSIs include, for instance, disinfecting the skin, maintaining body temperature, and ensuring an aseptic environment. Guidelines for most of these interventions exist, but there is a lack of studies describing to what extent the preventive interventions have been implemented in clinical practice. We describe the daily clinical interventions Swedish operating room (OR) nurses performed to prevent SSIs following national guidelines...
April 19, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29669739/tissue-stiffening-promotes-keratinocyte-proliferation-via-activation-of-epidermal-growth-factor-signaling
#2
Fiona N Kenny, Zoe Drymoussi, Robin Delaine-Smith, Alexander P Kao, Ana Catarina Laly, Martin M Knight, Michael P Philpott, John T Connelly
Tissue biomechanics regulate a wide range of cellular functions, but the influences on epidermal homeostasis and repair remain unclear. Here, we examined the role of extracellular matrix stiffness on human keratinocyte behavior using elastomeric substrates with defined mechanical properties. Increased matrix stiffness beyond normal physiologic levels promoted keratinocyte proliferation but did not alter the ability to self-renew or terminally differentiate. Activation of epidermal growth factor (EGF) signaling mediated the proliferative response to matrix stiffness and depended on focal adhesion assembly and cytoskeletal tension...
April 18, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29667559/improving-the-rhinomanometry-technique-using-benzoin-tincture
#3
F Arslan, Ü Yıldızoğlu, A Durmaz, S Çetinkaya
OBJECTIVE: In order to achieve a faster and more reliable anterior rhinomanometric evaluation, nasal skin was prepared using benzoin tincture solution, which provides simpler and better adhesion of the foam tape to the nasal skin. METHOD: Two consecutive anterior rhinomanometry measurements were made, one with and one without benzoin tincture application. RESULTS: The average time taken to perform classic foam tape anterior rhinomanometry without benzoin tincture application was 281...
April 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29662977/handheld-skin-printer-in-situ-formation-of-planar-biomaterials-and-tissues
#4
Navid Hakimi, Richard Cheng, Lian Leng, Mohammad Sotoudehfar, Phoenix Qing Ba, Nazihah Bakhtyar, Saeid Amini-Nik, Marc G Jeschke, Axel Günther
We present a handheld skin printer that enables the in situ formation of biomaterial and skin tissue sheets of different homogeneous and architected compositions. When manually positioned above a target surface, the compact instrument (weight <0.8 kg) conformally deposits a biomaterial or tissue sheet from a microfluidic cartridge. Consistent sheet formation is achieved by coordinating the flow rates at which bioink and cross-linker solution are delivered, with the speed at which a pair of rollers actively translate the cartridge along the surface...
April 17, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29662713/are-the-skin-scar-characteristics-and-closure-of-the-parietal-peritoneum-associated-with-pelvic-adhesions
#5
Numan Çim, Erkan Elçi, Gülhan Güneş Elçi, Necat Almalı, Recep Yıldızhan
Objective: To assess whether the abdominal scar characteristics and closure of the peritoneum were associated with pelvic adhesions. Materials and Methods: Patients who had undergone cesarean section between December 2015 and February 2016 were assessed prospectively in terms of age, gravida, body mass index, number of living children, number of cesarean sections, time passed since the last cesarean section, closure status of the peritoneum in the last cesarean section, presence of other diseases, smoking status, location of incision in the abdomen (medial, pfannenstiel) scar dimensions (length, width), scar status with respect to skin (hypertrophic, flat, depressive), scar color [color change/no color change (hyperpigmented/hypopigmented)], adhesion of bowel-omentum-uterus, omentum-anterior abdominal wall, uterus-anterior abdominal wall, uterus-bladder, bladder-anterior abdominal wall, fixed uterus, and uterus-omentum-anterior abdominal wall in abdominal exploration...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29660510/the-in-vivo-anti-fibrotic-function-of-calcium-sensitive-receptor-casr-modulating-poly-p-dioxanone-co-l-phenylalanine-prodrug
#6
Bing Wang, Aiping Wen, Chengmin Feng, Lijing Niu, Xin Xiao, Le Luo, Chengyi Shen, Jiang Zhu, Jun Lei, Xiaoming Zhang
In present study, the apoptosis induction and proliferation suppression effects of l-phenylalanine (l-Phe) on fibroblasts were confirmed. The action sites of l-Phe on fibroblasts suppression were deduced to be calcium sensitive receptor (CaSR) which could cause the release of endoplasmic reticulum (ER) Ca2+ stores; disruption of intracellular Ca2+ homeostasis triggers cell apoptosis via the ER or mitochondrial pathways. The down-regulation of CaSR were observed after the application of l-Phe, and the results those l-Phe triggered the increasing of intracellular Ca2+ concentration and calcineurin expression, and then the apoptosis and increasing G1 fraction of fibroblasts have verified our deduction...
April 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29659538/cell-adhesion-molecules-are-mediated-by-photobiomodulation-at-660-nm-in-diabetic-wounded-fibroblast-cells
#7
Nicolette N Houreld, Sandra M Ayuk, Heidi Abrahamse
Diabetes affects extracellular matrix (ECM) metabolism, contributing to delayed wound healing and lower limb amputation. Application of light (photobiomodulation, PBM) has been shown to improve wound healing. This study aimed to evaluate the influence of PBM on cell adhesion molecules (CAMs) in diabetic wound healing. Isolated human skin fibroblasts were grouped into a diabetic wounded model. A diode laser at 660 nm with a fluence of 5 J/cm² was used for irradiation and cells were analysed 48 h post-irradiation...
April 16, 2018: Cells
https://www.readbyqxmd.com/read/29656566/absence-of-human-skin-irritation-and-allergenic-potential-after-repeated-patch-applications-of-a-lamellar-moisturizer
#8
Stephanie J Nisbet
BACKGROUND: New cosmetic products should undergo clinical evaluation for skin sensitization potential. OBJECTIVES: To assess the irritation and sensitization potential of a moisturizer containing lamellar structured lipids after repeated patch application in humans, using human repeated insult patch test methodology. METHODS: This 6-week, single-center, open-label study compared a lamellar moisturizer with negative saline control in human subjects aged 18-70 years and skin phototype (Fitzpatrick) classification I-IV...
April 15, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29656072/enhanced-wound-healing-of-tissue-engineered-human-corneas-through-altered-phosphorylation-of-the-creb-and-akt-signal-transduction-pathways
#9
Camille Couture, Pascale Desjardins, Karine Zaniolo, Lucie Germain, Sylvain L Guérin
The cornea is a transparent organ, highly specialized and unique that is continually subjected to abrasive forces and occasional mechanical or chemical trauma because of its anatomical localization. Upon injury, the extracellular matrix (ECM) rapidly changes to promote wound healing through integrin-dependent activation of specific signal transduction mediators whose contribution is to favor faster closure of the wound by altering the adhesive and migratory properties of the cells surrounding the damaged area...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29643540/-verification-of-skin-paste-electrodes-used-in-wireless-polysomnography
#10
Y D Ma, D Huang, Y F Chen, H Y Jiang, J H Liu, H Q Sun, Z H Li
OBJECTIVE: To explore an electrode suitable for wireless portable sleep monitoring equipment and analyze the result of the signals of electrooculogram (EOG) and electroencephalography (EEG) collected by this kind of flexible electrodes. METHODS: The flexible electrodes were prepared by microelectromechanical systems (MEMS) technology. This kind of electrodes consisted parylene, chromium, and gold. Parylene, the flexible substrate of this kind of flexible electrodes, was of biocompatibility...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29630078/applications-of-zeolites-in-biotechnology-and-medicine-a-review
#11
REVIEW
Lucie Bacakova, Marta Vandrovcova, Ivana Kopova, Ivan Jirka
Zeolites are microporous tectosilicates of natural or synthetic origin, which have been extensively used in various technological applications, e.g. as catalysts and as molecular sieves, for separating and sorting various molecules, for water and air purification, including removal of radioactive contaminants, for harvesting waste heat and solar heat energy, for adsorption refrigeration, as detergents, etc. These applications of zeolites were typically related with their porous character, their high adsorption capacity, and their ion exchange properties...
April 9, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29628254/chitin-nanocrystal-enhanced-wet-adhesion-performance-of-mussel-inspired-citrate-based-soft-tissue-adhesive
#12
Yiwen Xu, Kai Liang, Wajeeh Ullah, Yali Ji, Jinghong Ma
Chitin nanocrystal (ChiNC) with its good biodegradability and biocompatibility as well as rod-like structure characteristic has become one of excellent nanofillers to enhance mechanical properties and bioactivity of biomedical polymers. For further extending its application fields, here, we dispersed ChiNC into a recently synthesized citrate-based tissue adhesive (POEC-d) and explored its effects on the adhesion and cytocompatibility of the adhesive. POEC-d, a mussel-inspired wet adhesive, was prepared by a one-pot melt polycondensation of 1, 8-octanediol, poly(ethylene oxide) (PEO), citric acid (CA) and dopamine (DA)...
June 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29625213/mechanistic-insights-of-the-controlled-release-properties-of-amide-adhesive-and-hydroxyl-adhesive
#13
Zheng Luo, Xiaocao Wan, Chao Liu, Liang Fang
Although interactions between drugs and acrylate pressure sensitive adhesives (PSAs) containing amide groups were reported in the previous studies, detailed studies elucidating their mechanism of action are still lacking. In the present study, an amide PSA (AACONH2 ) and a hydroxyl PSA (AAOH, as the control) were synthesized, and their molecular mechanism of controlled drug release was described. Using zolmitriptan (ZOL) and etodolac (ETO) as model drugs, in vitro drug release and skin permeation experiments were performed...
April 3, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29624049/a-skin-attachable-stretchable-electrochemical-sweat-sensor-for-glucose-and-ph-detection
#14
Seung Yun Oh, Soo Yeong Hong, Yu Ra Jeong, Junyeong Yun, Heun Park, Sang Woo Jin, Geumbee Lee, Ju Hyun Oh, Hanchan Lee, Sang-Soo Lee, Jeong Sook Ha
As part of increased efforts to develop wearable healthcare devices for monitoring and managing physiological and metabolic information, stretchable electrochemical sweat sensors have been investigated. In this study, we report on the fabrication of a stretchable and skin-attachable electrochemical sensor for detecting glucose and pH in sweat. A patterned stretchable electrode was fabricated via layer-by-layer deposition of carbon nanotubes (CNT) on top of patterned Au nanosheets (AuNS) prepared by filtration onto stretchable substrate...
April 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29622251/editorial-commentary-an-alternative-to-opioids-adhesive-drapes-and-chlorhexidine-skin-preparation-may-reduce-propionibacterium-acnes-related-pain-after-shoulder-surgery
#15
EDITORIAL
Bradford Burr Kraetzer
Propionibacterium acnes has long been known to play a detrimental role in shoulder surgery. This thoughtful and revealing study found significant evidence of lower rates of P. acnes cultured during arthroscopic rotator cuff repair with the use of an adhesive drape and chlorhexidine skin preparation.
April 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29621090/superficial-fascia-in-the-cheek-and-the-superficial-musculoaponeurotic-system
#16
Kun Hwang, Jung Ho Choi
The origins and validity of the term "superficial musculoaponeurotic system" (SMAS) is reviewed. Gray stated the superficial fascia connects the skin with the deep or aponeurotic fascia and consists of fibro-areolar tissue. Hollinshead wrote superficial fascia exists throughout the body and contains a variable amount of fat. In the head and neck, it encloses voluntary muscles in its deep portion. Skoog found superficial fascia was fixed to the dense, deep fascia by fibrous adhesions in the temporal, preauricular, and parotid area...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29616031/the-impact-of-the-epithelial-mesenchymal-transition-regulator-hepatocyte-growth-factor-receptor-met-on-skin-immunity-by-modulating-langerhans-cell-migration
#17
REVIEW
Zsofia Sagi, Thomas Hieronymus
Langerhans cells (LCs), the epidermal dendritic cell (DC) subset, express the transmembrane tyrosine kinase receptor Met also known as hepatocyte growth factor (HGF) receptor. HGF is the exclusive ligand of Met and upon binding executes mitogenic, morphogenic, and motogenic activities to various cells. HGF exerts anti-inflammatory activities via Met signaling and was found to regulate various functions of immune cells, including differentiation and maturation, cytokine production, cellular migration and adhesion, and T cell effector function...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29604249/requirement-of-zebrafish-pcdh10a-and-pcdh10b-in-melanocyte-precursor-migration
#18
Jason S Williams, Jessica Y Hsu, Christy Cortez Rossi, Kristin Bruk Artinger
Melanocytes derive from neural crest cells, which are a highly migratory population of cells that play an important role in pigmentation of the skin and epidermal appendages. In most vertebrates, melanocyte precursor cells migrate solely along the dorsolateral pathway to populate the skin. However, zebrafish melanocyte precursors also migrate along the ventromedial pathway, in route to the yolk, where they interact with other neural crest derivative populations. Here, we demonstrate the requirement for zebrafish paralogs pcdh10a and pcdh10b in zebrafish melanocyte precursor migration...
March 28, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29603432/in-vitro-epidermis-model-mimicking-igf-1-specific-age-related-decline
#19
Carine Mainzer, Noëlle Remoué, Jennifer Molinari, Patricia Rousselle, Carla Barricchello, Juliana C Lago, Pascal Sommer, Dominique Sigaudo-Roussel, Romain Debret
Aging is a complex multifaceted process affecting skin functionality and structure. Several 3D organotypic skin culture models have reproduced aging by inducing replicative senescence, glycation or oxidative stress. Yet, very few models have focused on hormonal aging and especially the insulin-like growth factor 1 (IGF-1) signaling pathway, which has been associated to longevity in animal studies and is necessary in the early stages of skin development. In this study, we built an organotypic epidermis model with targeted IGF-1 receptor knockdown to reproduce some aspects of hormonal aging on skin...
March 30, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29603366/imaging-of-magnetic-ink-patterns-via-off-resonance-sensitivity
#20
Stephanie L Perkins, Bruce L Daniel, Brian A Hargreaves
PURPOSE: Printed magnetic ink creates predictable B0 field perturbations based on printed shape and magnetic susceptibility. This can be exploited for contrast in MR imaging techniques that are sensitized to off-resonance. The purpose of this work was to characterize the susceptibility variations of magnetic ink and demonstrate its application for creating MR-visible skin markings. METHODS: The magnetic susceptibility of the ink was estimated by comparing acquired and simulated B0 field maps of a custom-built phantom...
March 30, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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