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https://www.readbyqxmd.com/read/29230909/histatins-wound-healing-and-cell-migration
#1
Pedro Torres, Martín Castro, Montserrat Reyes, Vicente A Torres
Wounds in the oral mucosa heal faster and more efficiently than those in the skin, although the mechanisms underlying these differences are not completely clear. In the last 10 years, a group of salivary peptides, the histatins, have gained attention on behalf of their ability to improve several phases of the wound healing process. In addition to their roles as antimicrobial agents and in enamel maintenance, histatins elicit other biological effects, namely by promoting the migration of different cell types contained in the oral mucosa and in non-oral tissues...
December 12, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29230227/anti-idiotypic-antibodies-against-bp-igg-prevent-type-xvii-collagen-depletion
#2
Mayumi Kamaguchi, Hiroaki Iwata, Yuiko Mori, Ellen Toyonaga, Hideyuki Ujiie, Yoshimasa Kitagawa, Hiroshi Shimizu
Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However, little is known about the precise mechanisms of IVIg in BP. We investigate the cellular effects of IVIg, toward treatments for BP. Keratinocytes were treated with IgG from BP patients (BP-IgG) and with IVIg, and then the COL17 expression was detected by Western blotting...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29229242/synthesis-characterisation-and-biomedical-applications-of-curcumin-conjugated-chitosan-microspheres
#3
T S Saranya, V K Rajan, Raja Biswas, R Jayakumar, S Sathianarayanan
Curcumin is a diaryl heptanoid of curcuminoids class obtained from Curcuma longa. It possesses various biological activities like anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Chitosan is a biocompatible, biodegradable and non-toxic natural polymer which enhances the adhesive property of the skin. Chemical conjugation will leads to sustained release action and to enhance the bioavailability. This study aims to synthesis and characterize biocompatible curcumin conjugated chitosan microspheres for bio-medical applications...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29226739/rutin-phospholipid-complex-in-polymer-matrix-for-long-term-delivery-of-rutin-via-skin-for-the-treatment-of-inflammatory-diseases
#4
Bhupen Kalita, Malay K Das
The drug with poor oral bioavailability necessitates the development of novel carrier for efficient drug delivery. This paper reports the rutin-phospholipid complex in polymer matrix for sustained delivery of rutin via the skin for the treatment of acute and chronic inflammatory diseases. Rutin in phospholipid complex (RNPs) are better soluble and permeable than the free rutin. The RNPs-loaded polymeric matrix patch with moderate adhesiveness was developed for convenient means of long term drug application on the skin...
December 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29225280/quaternary-ammonium-compounds-in-dental-restorative-materials
#5
Yu Zhang, Yinyan Chen, Yuntong Hu, Fang Huang, Yuhong Xiao
Quaternary ammonium compounds (QACs) have been used widely in medicine, owing to their antimicrobial properties. They also have strong permeability, stable performance, low skin irritation, low toxicity, low corrosion, lasting biological effects and so on, comparing with other antimicrobial agents. At the end of last century, polymerizable quaternary ammonium antimicrobial monomers had been synthesized and applied in dentistry, in order to reduce or prevent microbial biofilm formation on dental materials surfaces...
December 8, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29222810/monocytes-enhance-neutrophil-induced-blister-formation-in-an-ex-vivo-model-of-bullous-pemphigoid
#6
E de Graauw, C Sitaru, M P Horn, L Borradori, S Yousefi, D Simon, H-U Simon
BACKGROUND: Lesions of bullous pemphigoid (BP), an autoimmune subepidermal blistering disease characterized by the presence of tissue-bound and circulating autoantibodies to hemidesmosomal antigens, harbour a mixed inflammatory cellular infiltrate. In various models, neutrophils, eosinophils, mast cells, monocytes as well as B and T cells have been shown to be involved in the pathogenesis of BP. However, their interactions with and effective role in blister formation remains uncertain...
December 8, 2017: Allergy
https://www.readbyqxmd.com/read/29218605/oxymatrine-sensitizes-the-hacat-cells-to-the-ifn-%C3%AE-pathway-and-downregulates-mdc-icam-1-and-socs1-by-activating-p38-jnk-and-akt
#7
Chun-Jie Gao, Pei-Jun Ding, Li-Li Yang, Xu-Feng He, Meng-Jiao Chen, Dong-Ming Wang, Yan-Xin Tian, Hui-Min Zhang
Decreased interferon (IFN)-γ levels and increased levels of macrophage-derived chemokine (MDC) and intercellular adhesion molecule (ICAM)-1 are known to be involved in allergic skin diseases, such as eczema and atopic dermatitis. Activation of the IFN-γ and its downstream interleukin-12 (IL-12) pathway can correct these diseases. Suppressor of cytokine signaling 1 (SOCS1) is a cytokine signaling inhibitor that blocks downstream pathways of IFN-γ by blocking the mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) signaling pathways...
December 7, 2017: Inflammation
https://www.readbyqxmd.com/read/29216182/the-physicochemical-fingerprint-of-necator-americanus
#8
Veeren M Chauhan, David J Scurr, Thomas Christie, Gary Telford, Jonathan W Aylott, David I Pritchard
Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world's population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs (L3) to the intestinal tract (L4 maturing to adult). It has been hypothesised that the L3 larval sheath, which is shed during percutaneous infection (exsheathment), diverts the immune system to allow successful infection and reinfection in endemic areas. However, the physicochemical properties of the L3 larval cuticle and sheath, which are in direct contact with the skin and its immune defences, are unknown...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29215303/influence-of-cryopreservation-solution-on-the-in-vitro-culture-of-skin-tissues-derived-from-collared-peccary-pecari-tajacu-linnaeus-1758
#9
Alana A Borges, Gabriela P O Lira, Lucas E Nascimento, Luiza B Queiroz Neta, Maria V O Santos, Moacir F Oliveira, Alexandre R Silva, Alexsandra F Pereira
Skin vitrification is a promising and alternative tool for the conservation of biodiversity, especially for wild mammals, such as collared peccaries. Several factors can affect the success of this procedure, such as the cryoprotectant solution used. Therefore, this study was carried out to compare the efficiency of various vitrification solutions for recovery of viable cells after in vitro culture of cryopreserved skin tissues derived from the collared peccary, aiming to study the application in biobanking, where cellular use is not immediately required...
December 7, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29215016/low-neurotrophin-receptor-cd271-regulates-phenotype-switching-in-melanoma
#10
Gaetana Restivo, Johanna Diener, Phil F Cheng, Gregor Kiowski, Mario Bonalli, Thomas Biedermann, Ernst Reichmann, Mitchell P Levesque, Reinhard Dummer, Lukas Sommer
Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic capacity. According to the "phenotype switching" model, the aggressive nature of melanoma cells results from their intrinsic potential to dynamically switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive state. Here we identify the low affinity neurotrophin receptor CD271 as a key effector of phenotype switching in melanoma. CD271 plays a dual role in this process by decreasing proliferation, while simultaneously promoting invasiveness...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29210562/methacrylate-stitched-%C3%AE-cyclodextrin-embedded-with-nanogold-nanotitania-a-skin-adhesive-device-for-enhanced-transdermal-drug-delivery
#11
Thayyath Sreenivasan Anirudhan, Syam S Nair, Athira V Sasidharan
Transdermal (TD) drug delivery is an attractive technique for drug delivery compared to oral and intravenous injection. However the permeation of drug molecules across the skin is difficult due to the presence of highly ordered lipid barrier. This investigation details the development of a novel TD system, which has the potential to simultaneously enhance the skin permeability and adhesion behavior. Ibuprofen (IP) was selected as model drug. The ability of gold nanoparticle (AuNP) and hydrophobic titanium nanotube (TNT) to enhance the skin permeability was explored...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29209359/wnt-%C3%AE-catenin-signaling-pathway-regulates-specific-lncrnas-that-impact-dermal-fibroblasts-and-skin-fibrosis
#12
Nathaniel K Mullin, Nikhil V Mallipeddi, Emily Hamburg-Shields, Beatriz Ibarra, Ahmad M Khalil, Radhika P Atit
Wnt/β-catenin signaling is required for embryonic dermal fibroblast cell fate, and dysregulation of this pathway is sufficient to promote fibrosis in adult tissue. The downstream modulators of Wnt/β-catenin signaling required for controlling cell fate and dermal fibrosis remain poorly understood. The discovery of regulatory long non-coding RNAs (lncRNAs) and their pivotal roles as key modulators of gene expression downstream of signaling cascades in various contexts prompted us to investigate their roles in Wnt/β-catenin signaling...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29208742/force-induced-strengthening-of-the-interaction-between-staphylococcus-aureus-clumping-factor-b-and-loricrin
#13
Pauline Vitry, Claire Valotteau, Cécile Feuillie, Simon Bernard, David Alsteens, Joan A Geoghegan, Yves F Dufrêne
Bacterial pathogens that colonize host surfaces are subjected to physical stresses such as fluid flow and cell surface contacts. How bacteria respond to such mechanical cues is an important yet poorly understood issue. Staphylococcus aureus uses a repertoire of surface proteins to resist shear stress during the colonization of host tissues, but whether their adhesive functions can be modulated by physical forces is not known. Here, we show that the interaction of S. aureus clumping factor B (ClfB) with the squamous epithelial cell envelope protein loricrin is enhanced by mechanical force...
December 5, 2017: MBio
https://www.readbyqxmd.com/read/29207049/coordinated-microrna-mrna-expression-profiles-reveal-a-putative-mechanism-of-corneal-epithelial-cell-transdifferentiation-from-skin-epidermal-stem-cells
#14
Yanjie Guo, Xiya Ma, Weini Wu, Mingyan Shi, Junlong Ma, Yaping Zhang, Erkang Zhao, Xueyi Yang
Skin epidermal stem cells (SESCs), which share a single origin with corneal epithelial cells (CECs), are considered to be one of the most ideal seed cells for the construction of tissue engineered corneas. However, the mechanism underlying the transdifferentiation of SESCs to CECs has not been fully elucidated. In the present study, to identify critical microRNAs (miRNAs/miRs) and genes that regulate the transdifferentiation of SESCs to CECs, SESCs and CECs were collected from sheep and used for small RNA sequencing and mRNA microarray analyses...
December 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29206923/vascular-abnormalities-in-the-placenta-of-chst14-fetuses-implications-in-the-pathophysiology-of-perinatal-lethality-of-the-murine-model-and-vascular-lesions-in-human-chst14-d4st1-deficiency
#15
Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin'ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, Tomoki Kosho
Collagen is one of the most important components of the extracellular matrix that is involved in the strength of tissues, cell adhesion, and cell proliferation. Mutations in several collagen and post-translational modification enzyme genes cause Ehlers-Danlos syndrome (EDS) characterized by joint and skin hyperextensibility as well as fragility of various organs. Carbohydrate sulfotransferase 14/dermatan 4-O-sulfotransferase-1 (CHST14/D4ST1) is a critical enzyme for biosynthesis of dermatan sulfate, a side chain of various proteoglycans including biglycan that regulates collagen fibrils through their interaction...
December 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/29206362/prevalence-of-neonate-adhesive-skin-injuries-in-a-jordanian-intensive-care-unit
#16
Laila Habiballah
AIM: To determine the prevalence of adhesive skin injuries in neonates in a Jordanian neonatal intensive care unit (NICU) and to examine the characteristics of neonates with these injuries. METHOD: A cross-sectional period-prevalence study was conducted in a NICU in Irbid National University Hospital in Jordan. A total of 169 neonates were examined for skin injuries caused by adhesive equipment. RESULTS: The prevalence of skin injuries in this population was 26...
December 5, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29205950/biodegradable-nanoparticles-enhanced-adhesiveness-of-mussel-like-hydrogels-at-tissue-interface
#17
Nikhil Pandey, Amirhossein Hakamivala, Cancan Xu, Prashant Hariharan, Boris Radionov, Zhong Huang, Jun Liao, Liping Tang, Philippe Zimmern, Kytai T Nguyen, Yi Hong
Popular bioadhesives, such as fibrin, cyanoacrylate, and albumin-glutaraldehyde based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, their performances are limited by weak adhesion strength and rapid degradation. In this study a mussel-inspired, nanocomposite-based, biodegradable tissue adhesive is developed by blending poly(lactic-co-glycolic acid) (PLGA) or N-hydroxysuccinimide modified PLGA nanoparticles (PLGA-NHS) with mussel-inspired alginate-dopamine polymer (Alg-Dopa)...
December 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29204689/comparison-between-over-glasses-patching-and-adhesive-patching-for-children-with-moderate-amblyopia-a-prospective-randomized-clinical-trial
#18
Su Jin Kim, Hyeshin Jeon, Jae Ho Jung, Kwang Min Lee, Hee Young Choi
PURPOSE: To investigate efficacy of over-glasses patching treatment for amblyopic children using visual function improvement and Amblyopia Treatment Index (ATI) changes. METHODS: In a randomized multi-center controlled clinical trial, 107 children aged 3-7 years with moderate amblyopia (visual acuity in the range of 20/40 to 20/100) were included to receive treatment with either an adhesive skin patch or a fabric over-glasses patch. The patients were prescribed 2 h of patching per day for the sound eye...
December 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29204384/approach-to-a-child-with-primary-immunodeficiency-made-simple
#19
REVIEW
Dhrubajyoti Sharma, Ankur K Jindal, Amit Rawat, Surjit Singh
Primary immunodeficiency disorders (PIDs) are a group of disorders affecting the capability to fight against infection. These include defects in T cells and B cells affecting cell-mediated and humoral immunity, respectively, combined humoral and cell-mediated immunodeficiency, defects in phagocytosis, complement defects, and defects in cytokine or cytokine signalling pathways which are detrimental for immune function. Depending upon the type and severity, age at onset of symptoms can vary from neonatal period to late childhood...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29201111/cytokine-indexes-in-pemphigus-vulgaris-perception-of-its-immunpathogenesis-and-hopes-for-non-steroidal-treatment
#20
Mohsen Masjedi, Nafiseh Esmaeil, Ali Saffaei, Bahareh Abtahi-Naeini, Mohsen Pourazizi, Shaghayegh Haghjooy Javanmard, Ali Asilian
Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease of the skin, in which loss of adhesion between keratinocytes is caused by autoantibodies. It has been hypothesized that cytokines play an essential role in the pathogenesis of PV. This study aimed to investigate the other immunopathological aspects of PV by determining the serum levels of cytokines in PV patients to find another treatment strategy except corticosteroid therapy. Twenty-three patients with PV and a control group consisting of 24 healthy subjects were studied...
2017: Iranian Journal of Pharmaceutical Research: IJPR
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