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High flow oxyge

Gregor I Kemming, Franz G Meisner, Christoph J Wojtczyk, Kristian B Packert, Thomas Minor, Manfred Thiel, Jochen Tillmanns, Jens Meier, Daniel Bottino, Peter E Keipert, Simon Faithfull, Oliver P Habler
Perfluorocarbon (PFC) emulsions are intravascular oxygen therapeutics that temporarily enhance tissue oxygenation in dilutional anemia. However, PFC emulsions are not resuscitation fluids because PFCs only work optimally in the presence of high O2 partial pressure (hyperoxia); moreover, because they have no oncotic potential, dosing limitations prevent their use to permanently replace large hemorrhage volumes. Our objective was to clarify whether in the presence of hyperoxia a conventional colloid therapy supplemented by PFC is more efficacious than colloid alone...
September 2005: Shock
Milica Radisic, William Deen, Robert Langer, Gordana Vunjak-Novakovic
A steady-state model of oxygen distribution in a cardiac tissue construct with a parallel channel array was developed and solved for a set of parameters using the finite element method and commercial software (FEMLAB). The effects of an oxygen carrier [Oxygent; 32% volume perfluorocarbon (PFC) emulsion] were evaluated. The parallel channel array mimics the in vivo capillary tissue bed, and the PFC emulsion has a similar role as the natural oxygen carrier hemoglobin in increasing total oxygen content. The construct was divided into an array of cylindrical domains with a channel in the center and tissue space surrounding the channel...
March 2005: American Journal of Physiology. Heart and Circulatory Physiology
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