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Neurosurgical infections

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https://www.readbyqxmd.com/read/29387342/efficacy-of-intravenous-plus-intrathecal-intracerebral-ventricle-injection-of-polymyxin-b-for-post-neurosurgical-intracranial-infections-due-to-mdr-xdr-acinectobacter-baumannii-a-retrospective-cohort-study
#1
Sijun Pan, Xiaofang Huang, Yesong Wang, Li Li, Changyun Zhao, Zhongxiang Yao, Wei Cui, Gensheng Zhang
Background: Post-neurosurgical intracranial infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii are difficult to treat and associated with high mortality. In this study, we analyzed the therapeutic efficacy of intravenous combined with intrathecal/intracerebral ventricle injection of polymyxin B for this type of intracranial infection. Methods: This retrospective study was conducted from January 2013 to September 2017 at the Second Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou,China) and included 61 cases for which cerebrospinal fluid (CSF) cultures were positive for multidrug-resistant or extensively drug-resistant A...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29377880/evaluation-of-oxfendazole-in-the-treatment-of-zoonotic-onchocerca-lupi-infection-in-dogs
#2
Vito Colella, Carla Maia, André Pereira, Nuno Gonçalves, Marta Caruso, Coralie Martin, Luis Cardoso, Lenea Campino, Ivan Scandale, Domenico Otranto
The genus Onchocerca encompasses parasitic nematodes including Onchocerca volvulus, causative agent of river blindness in humans, and the zoonotic Onchocerca lupi infecting dogs and cats. In dogs, O. lupi adult worms cause ocular lesions of various degrees while humans may bear the brunt of zoonotic onchocercosis with patients requiring neurosurgical intervention because of central nervous system localization of nematodes. Though the zoonotic potential of O. lupi has been well recognized from human cases in Europe, the United States and the Middle East, a proper therapy for curing this parasitic infection in dogs is lacking...
January 29, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29364007/complication-rates-of-external-ventricular-drain-insertion-by-surgeons-of-different-experience
#3
J Yuen, W Selbi, S Muquit, T Berei
Introduction Insertion of external ventricular drain (EVD) is a widely accepted, routinely performed procedure for treatment of hydrocephalus and raised intracranial pressure. The purpose of this study was to investigate whether a surgeon's experience affects the associated complication rate. Methods This retrospective study included all adult patients undergoing EVD insertion at a single centre between July 2013 and June 2015. Medical records were retrieved to obtain details on patient demographics, surgical indication, risk factors for infection and use of anticoagulants or antiplatelets...
January 24, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29355796/clinical-utility-of-serum-procalcitonin-level-and-infection-in-the-neurosurgical-intensive-care-unit
#4
Lauren E Rotman, Bonita S Agee, Gustavo Chagoya, Matthew C Davis, James M Markert
OBJECTIVE: Procalcitonin, a blood stream inflammatory biomarker, has shown to be useful in the diagnosis of sepsis in critically ill patients treated in medical and surgical intensive care units. This study aims to further our understanding of procalcitonin levels in Neuroscience Intensive Care Unit (NICU) patients. METHODS: Neurosurgical patients who underwent procalcitonin assay in the NICU over a two-year period were included. Procalcitonin equal to or above 0...
January 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29354758/gibbus-deformity-after-non-tuberculosis-osteomyelitis
#5
Akop Seksenyan, Darian R Esfahani, Kimberly Hu, Ankit I Mehta
Gibbus deformities are characterized by anterior collapse of one or more vertebral bodies resulting in kyphosis. These deformities usually arise from spinal infections, and are traditionally associated with tuberculosis; other pathogens are rarely reported in the literature. In this case report, the authors describe a patient with a sharp, angulated Gibbus deformity presenting with back pain and myelopathy. The patient was placed on antibiotics, underwent T11-T12 corpectomy, placement of an expandable cage, and T8-L3 fusion with improvement of symptoms...
December 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29348274/sinogenic-intracranial-complications-is-adalimumab-a-culprit
#6
Mikkel Seremet Kofoed, Niels Fisker, Anne Estmann Christensen, Anette Drøhse Kjeldsen
We present two 11-year-old girls with chronic recurrent multifocal osteomyelitis, treated with adalimumab. Both developed severe intracranial complications to sinusitis. Patient 1 had been treated with adalimumab for 15 months when she developed acute sinusitis complicated by an orbital abscess, forehead swelling, a subdural empyema and osteomyelitis of the frontal bone. She was treated with a rhinosurgical and neurosurgical approach with intravenous antibiotics.Patient 2 had been in adalimumab treatment for 10 weeks...
January 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29310378/isolated-cerebral-aspergillosis-in-an-immunocompetent-woman-on-treatment-for-bacterial-infected-necrotizing-pancreatitis-a-case-report
#7
Shaoyang Zhang, Qinghui Fu, Qi Chen, Ting-Bo Liang
RATIONALE: Cerebral aspergillosis (CA) is a rare manifestation of invasive aspergillosis. It usually affects seriously immunocompromised hosts. Pancreatic bacterial or/and fungal infection is common in patients with severe acute pancreatitis. PATIENT CONCERNS: We report the first case of an immunocompetent woman with infected necrotizing pancreatitis due to multidrug resistant Acinetobacter baumannii who, in the course of treatment, developed isolated CA. DIAGNOSES: Magnetic resonance imaging, rather than computed tomography, revealed latent homolateral sinus disease-the possible source of the Aspergillus infection...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29303458/complications-following-intracranial-pressure-monitoring-in-children-a-6-year-single-center-experience
#8
Ruichong Ma, David Rowland, Andrew Judge, Amedeo Calisto, Jayaratnam Jayamohan, David Johnson, Peter Richards, Shailendra Magdum, Steven Wall
OBJECTIVE Intracranial pressure (ICP) monitoring is an important tool in the neurosurgeon's armamentarium and is used for a wide range of indications. There are many different ICP monitors available, of which fiber-optic intraparenchymal devices are very popular. Here, the authors document their experience performing ICP monitoring from 2005 to 2015 and specifically complication rates following insertion of the Microsensor ICP monitor. METHODS A retrospective case series review of all patients who underwent ICP monitoring over a 10-year period from 2005 to 2015 was performed...
January 5, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29297142/bacterial-infections-of-the-central%C3%A2-nervous-system
#9
REVIEW
Renu Suthar, Naveen Sankhyan
Bacterial infections of the central nervous system (CNS) continue to be an important cause of morbidity and mortality in children. The spectrum of bacterial infection of CNS includes; focal or multifocal infections like brain abscesses or subdural empyema; or more generalized or diffuse infections like pyogenic meningitis or ventriculitis. Focal and generalized infections may co-exist in an individual patient. Prompt and adequate antibiotic therapy and occasionally neurosurgical interventions are the cornerstone of effective management...
January 3, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29273384/surgical-technique
#10
REVIEW
Marc Guénot, Axel Lebas, Bertrand Devaux, Sophie Colnat-Coulbois, Georg Dorfmuller, Aileen McGonigal, Nicolas Reyns, Vianney Gilard, Stéphane Derrey, Jean-Christophe Sol, Stéphane Clémenceau
In SEEG, as for any surgical procedure, the benefit/risk ratio is a key-point. This implies rigorous clinical practice in terms of indication, information delivered to the patient, and surgical technique. Numerous technical options may be used to achieve this goal. All are valuable, as long as they are executed with rigor and consistency. Intracranial bleeding represents the main risk of the procedure (1-4% of cases). The procedure also carries a risk of infection (0.8%), death (total of 6 reported cases in all the literature, <0...
December 19, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29260909/endoscopic-neuroendoscopy-using-a-novel-ventricular-access-port
#11
Andrew John Gauden, Calum Pears, Andrew Parker, Kelvin Woon, Helge Köck, Martin Hunn, Warren Symons, Agadha Wickremesekera
BACKGROUND: Hydrocephalus remains an important aspect of neurosurgical care and in select circumstances, the endoscopic third ventriculostomy (ETV) continues to remain an important treatment. In our initial experience of ETV using the commercially available plastic ventricular ports we found them both restrictive and expensive. Following this experience, we developed a stainless steel ventricular access port (VAP). We present our novel method of access involving this non-disposable ventricular port...
December 20, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29241820/outcomes-of-adjunctive-therapy-with-intrathecal-or-intraventricular-administration-of-colistin-for-post-neurosurgical-meningitis-and-ventriculitis-due-to-carbapenem-resistant-acinetobacter-baumannii
#12
Sarunyou Chusri, Ittichai Sakarunchai, Narongdet Kositpantawong, Siripen Panthuwong, Wichai Santimaleeworagun, Sutthiporn Pattharachayakul, Kamonnut Singkhamanan, Yohei Doi
The efficacy and safety of intrathecal or intraventricular (ITH/IVT) colistin in addition to intravenous (IV) colistin for meningitis and ventriculitis due to carbapenem-resistant Acinetobacter baumannii (CRAB) is unclear. In this retrospective observational study of 40 patients with post-neurosurgical meningitis and ventriculitis due to CRAB, 33 patients without concomitant infection received appropriate dosage regimens of IV colistin. Seventeen of the 33 patients received additional ITH/IVT colistin and 16 patients received only IV colistin...
December 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29226091/successful-treatment-of-multicompartmental-cerebral-ventriculitis-caused-by-acinetobacter-baumanii
#13
Mahableshwar Albur
We present a case report of a 58-year- old woman with subarachnoid haemorrhage complicated by non-communicating hydrocephalus. During the course of her neurosurgical management, she developed external-ventricular drain associated ventriculitis which in turn was complicated by lack of communication between third and fourth ventricles. The causative organism was a fully-sensitive Acinetobacter baumanii, a nosocomial pathogen often associated with complicated treatment regimens and poor outcomes. This patient was successfully managed by a multi-disciplinary team involving neurosurgeons, neuroradiologists and infection specialists...
2018: IDCases
https://www.readbyqxmd.com/read/29222684/how-much-do-plastic-surgeons-add-to-the-closure-of-myelomeningoceles
#14
Rhian Bevan, Nicholas Wilson-Jones, Imran Bhatti, Chirag Patel, Paul Leach
PURPOSE: This study reviews the outcomes of children undergoing myelomeningocele (MMC) repair in the paediatric neurosurgical department in Cardiff. These procedures are historically performed by paediatric neurosurgeons with occasional support from plastic surgeons for the larger lesions. We reviewed the postoperative outcomes over a 9-year period to assess the efficacy of having a plastic surgeon present at all MMC closures. METHODS: Analysis of a prospectively collected database of all MMC closures performed at University Hospital Wales from April 2009 to August 2017 was used...
December 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29213169/clinical-profile-of-neural-tube-defects-in-sudanese-children-is-malaria-a-risk-factor
#15
Basma Sadik, Haydar E Babikir, Mohammed A R Arbab
Neural tube defects (NTDs) are one of the most common structural malformations in human kind. It is a public health problem with great impact on the child, parents and the community at large. The aim is to study the epidemiological profile and patterns of NTDs in under five-year of age Sudanese children who attended the neurosurgical clinic at the National Centre of Neurological Sciences (NCNS), Khartoum during the period from March 2014 to December 2014. This was a prospective cross-sectional study conducted at the neurosurgery clinic in NCNS, Khartoum...
2017: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/29201853/proper-management-of-posttraumatic-tension-pneumocephalus
#16
Jinwon Kwon, Hyoung Kyun Rha, Hae Kwan Park, Chung Kee Chough, Won Il Joo, Sung Hoon Cho, Wonmo Gu, Wonjun Moon, Jaesung Han
Pneumocephalus is commonly seen after craniofacial injury. The pathogenesis of pneumocephalus has been debated as to whether it was caused by ball valve effect or combined episodic increased pressure within the nasopharynx on coughing. Discontinuous exchange of air and cerebrospinal fluid due to "inverted bottle" effect is assumed to be the cause of it. Delayed tension pneumocephalus is not common, but it requires an active management in order to prevent serious complication. We represent a clinical case of a 57-year-old male patient who fell down from 3 m height, complicated by tension pneumocephalus on 5 months after trauma...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29201850/remote-hemorrhage-after-burr-hole-drainage-of-chronic-subdural-hematoma
#17
Chang Hyeun Kim, Geun Sung Song, Young Ha Kim, Young Soo Kim, Soon Ki Sung, Dong Wuk Son, Sang Weon Lee
Chronic subdural hematoma (CSDH) and symptomatic subdural hygroma are common diseases that require neurosurgical management. Burr hole trephination is the most popular surgical treatment for CSDH and subdural hygroma because of a low recurrence rate and low morbidity compared with craniotomy with membranectomy, and twist-drill craniotomy. Many reports suggest that placing a catheter in the subdural space for drainage can further reduce the rate of recurrence; however, complications associated with this type of drainage include acute subdural hematoma, cortical injury, and infection...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29198174/intracranial-complications-of-midline-nasal-dermoid-cysts
#18
Dries Opsomer, Toon Allaeys, Ann-Sofie Alderweireldt, Edward Baert, Nathalie Roche
BACKGROUND: Nasal dermoid cysts are common tumors in children. Due to anomalies in embryologic development of the nasal complex, sometimes an intracranial extension exists. When these cysts become infected they can lead to meningitis, brain abscess and death. METHODS: We report the case of a 1.5-year-old girl admitted to the paediatric intensive care unit after infection of a nasal dermoid cyst. RESULTS: The infant had a spiking fever and epileptic seizures...
December 4, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29196812/early-elective-delivery-for-fetal-ventriculomegaly-are-neurosurgical-and-medical-complications-mitigated-by-this-practice
#19
Clinton D Morgan, Travis R Ladner, George L Yang, Marjorie N Moore, Russell D Parks, William F Walsh, John C Wellons, Chevis N Shannon
PURPOSE: Antenatally diagnosed ventriculomegaly (VM) requires the balance of risks of neurological injury with premature delivery. The purpose of this study was to evaluate outcomes related to early elective delivery due to fetal VM at our institution. METHODS: We retrospectively assessed 120 babies (2008-2012) with antenatally diagnosed fetal VM. Inclusion criteria for ("early") cohort were (1) elective delivery occurred for expedited neurosurgical intervention between 32 and 36 weeks EGA and (2) fetal VM noted on official antenatal ultrasound...
December 1, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29192622/subdural-empyema-clinical-presentations-and-management-options-for-an-uncommon-neurosurgical-emergency-in-a-developing-country
#20
M C Chikani, W Mezue, E Okorie, C Mbachu, C Ndubisi, U N Chikani
BACKGROUND: Controversy regarding the best management strategy for subdural empyema (SDE) attests to the persisting poor outcomes for this uncommon life threatening intracranial suppurative process. Late presentation confounds the problem in developed countries. While craniotomy is commonly recommended, it is not always possible in late presentation with advanced morbidity. The aim of this study was to identify the pattern of clinical presentation and explore the outcomes following management of SDE using burr hole, aspiration, and drainage (BAAD) in resource poor settings...
October 2017: Nigerian Journal of Clinical Practice
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