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Chest CT for screening for lung cancer

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https://www.readbyqxmd.com/read/28169345/bronchoalveolar-lavage-proteomics-in-patients-with-suspected-lung-cancer
#1
Ana Sofia Carvalho, Célia Marina Cuco, Carla Lavareda, Francisco Miguel, Mafalda Ventura, Sónia Almeida, Paula Pinto, Tiago Tavares de Abreu, Luís Vaz Rodrigues, Susana Seixas, Cristina Bárbara, Mikel Azkargorta, Felix Elortza, Júlio Semedo, John K Field, Leonor Mota, Rune Matthiesen
Lung cancer configures as one of the deadliest types of cancer. The future implementation of early screening methods such as exhaled breath condensate analysis and low dose computed tomography (CT) as an alternative to current chest imaging based screening will lead to an increased burden on bronchoscopy units. New approaches for improvement of diagnosis in bronchoscopy units, regarding patient management, are likely to have clinical impact in the future. Diagnostic approaches to address mortality of lung cancer include improved early detection and stratification of the cancers according to its prognosis and further response to drug treatment...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28135349/use-of-ct-and-chest-radiography-for-lung-cancer-screening-before-and-after-publication-of-screening-guidelines-intended-and-unintended-uptake
#2
Jinhai Huo, Chan Shen, Robert J Volk, Ya-Chen Tina Shih
No abstract text is available yet for this article.
January 30, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28093625/ultralow-dose-ct-for-pulmonary-nodule-detection-with-chest-x-ray-equivalent-dose-a-prospective-intra-individual-comparative-study
#3
Michael Messerli, Thomas Kluckert, Meinhard Knitel, Stephan Wälti, Lotus Desbiolles, Fabian Rengier, René Warschkow, Ralf W Bauer, Hatem Alkadhi, Sebastian Leschka, Simon Wildermuth
PURPOSE: To prospectively evaluate the accuracy of ultralow radiation dose CT of the chest with tin filtration at 100 kV for pulmonary nodule detection. MATERIALS AND METHODS: 202 consecutive patients undergoing clinically indicated chest CT (standard dose, 1.8 ± 0.7 mSv) were prospectively included and additionally scanned with an ultralow dose protocol (0.13 ± 0.01 mSv). Standard dose CT was read in consensus by two board-certified radiologists to determine the presence of lung nodules and served as standard of reference (SOR)...
January 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28091834/using-twitter-to-assess-the-public-response-to-the-united-states-preventive-services-task-force-guidelines-on-lung-cancer-screening-with-low-dose-chest-ct
#4
Siddharth Khasnavis, Andrew B Rosenkrantz, Vinay Prabhu
To use Twitter to assess the immediate public response to the United States Preventive Services Task Force (USPSTF) 2013 draft guidelines on lung cancer screening with low-dose chest CT (LDCT). The number of tweets including the phrases "lung cancer screening," "lung CT," "chest CT," "low dose computed tomography," "low dose CT," or "LDCT" was recorded for 6 days before and after guidelines release. A systematic sample of 172 tweets from the week following release was coded for user type, tweet opinion, linked article source, and article opinion...
January 13, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28048107/su-f-i-04-low-dose-ct-lung-cancer-screening-protocol-evaluation
#5
E Nett, Y Imai
PURPOSE: The purpose of this study was to evaluate protocols for low dose CT (LDCT) for lung cancer screening on a Revolution CT (GE Healthcare; Waukesha, WI). Lung cancer the leading cause of cancer death for men and women, and more deaths are attributable to lung cancer than breast, colon and prostate cancers combined. Recently, the National Lung Screening Trial (NLST) showed LDCT screening resulted in a 20% reduction in lung cancer mortality and 6.7% in mortality from all causes [NEJM, 2011]...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041890/point-should-only-primary-care-physicians-provide-shared-decision-making-services-to-discuss-the-risks-benefits-of-a-low-dose-chest-ct-for-lung-cancer-screening-yes
#6
EDITORIAL
https://www.readbyqxmd.com/read/28041887/counterpoint-should-only-primary-care-physicians-provide-shared-decision-making-services-to-discuss-the-risks-benefits-of-a-low-dose-chest-ct-for-lung-cancer-screening-no
#7
EDITORIAL
https://www.readbyqxmd.com/read/28005439/early-lung-cancer-detection-by-low-dose-ct-screening-therapeutic-implications
#8
Marjolein A Heuvelmans, Harry J M Groen, Matthijs Oudkerk
Lung cancer screening by low-dose chest computed tomography is currently implemented in the U.S. After implementation of screening, a stage shift may be observed from around 15% stage I non-small cell lung cancers (NSCLCs) in routine clinical practice to up to 70% in screening patients. This indicates a move in treatment options from advanced to early lung cancers, especially in those with small suspected intrapulmonary nodules. Areas covered: We have reviewed the current status of lung cancer screening from the different randomized controlled lung cancer screening studies and the clinical evidence so far for both surgical and non-surgical treatment options for (screen-detected) stage I NSCLC...
December 30, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27814824/acr-appropriateness-criteria-%C3%A2-stage-i-breast-carcinoma
#9
Phan Tuong Huynh, Sergy V Lemeshko, Mary C Mahoney, Mary S Newell, Lisa Bailey, Lora D Barke, Carl D'Orsi, Jennifer A Harvey, Mary K Hayes, Peter M Jokich, Su-Ju Lee, Constance D Lehman, Martha B Mainiero, David A Mankoff, Samir B Patel, Handel E Reynolds, M Linda Sutherland, Bruce G Haffty
Stage I breast carcinoma is classified when an invasive breast carcinoma is ≤2 cm in diameter (T1), with no regional (axillary) lymph node metastases (N0) and no distant metastases (M0). The most common sites for metastases from breast cancer are the skeleton, lung, liver, and brain. In general, women and health care professionals prefer intensive screening and surveillance after a diagnosis of breast cancer. Screening protocols include conventional imaging such as chest radiography, bone scan, ultrasound of the liver, and MRI of brain...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27743826/-lung-cancer-screening-with-low-dose-thoracic-ct-scan-in-the-somme-area
#10
O Leleu, M Auquier, O Carre, B Chauffert, A Dubreuil, V Petigny, B Trancart, P Berna, V Jounieaux
RATIONALE: This feasibility trial proposes to set up in the department of the Somme an annual screening for lung cancer with low-dose thoracic CT. It responds to the first objective of the third cancer plan and follows the publication of the results of the National Lung Screening Trial in 2011. METHODS: The method of this study is to use the existing networks among and between healthcare professionals and the departmental cancer screening structure. The inclusion criteria will be those of the National Lung Screening Trial...
October 12, 2016: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/27736916/can-ct-screening-give-rise-to-a-beneficial-stage-shift-in-lung-cancer-patients-systematic-review-and-meta-analysis
#11
Zixing Wang, Yaoda Hu, Yuyan Wang, Wei Han, Lei Wang, Fang Xue, Xin Sui, Wei Song, Ruihong Shi, Jingmei Jiang
OBJECTIVES: To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there's universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach. MATERIALS AND METHODS: EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2...
2016: PloS One
https://www.readbyqxmd.com/read/27732988/obstacles-to-and-solutions-for-a-successful-lung-cancer-screening-program
#12
Peter J Mazzone
Lung cancer screening with a low radiation dose chest CT scan has been shown to reduce the number of people, in a well-defined very high-risk cohort, who die from lung cancer. Many potential screening-related harms have been identified, including anxiety and morbidity related to the evaluation of screen-detected findings. A favorable balance of the benefit and harms of lung cancer screening requires careful implementation of a screening program, with a focus on several obstacles to the success of the program...
October 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27652202/from-diagnosis-to-therapy-in-lung-cancer-management-of-ct-detected-pulmonary-nodules-a-summary-of-the-2015-chinese-german-lung-cancer-expert-panel
#13
REVIEW
Chunxia Su, Mathias Meyer, Robert Pirker, Wieland Voigt, Jingyun Shi, Lothar Pilz, Rudolf M Huber, Yilong Wu, Jinghong Wang, Yonglan He, Xuan Wang, Jian Zhang, Xiuyi Zhi, Meiqi Shi, Bo Zhu, Stefan S Schoenberg, Thomas Henzler, Christian Manegold, Caicun Zhou, Eric Dominic Roessner
The first Chinese-German Lung Cancer Expert Panel was held in November 2015 one day after the 7th Chinese-German Lung Cancer Forum, Shanghai. The intention of the meeting was to discuss strategies for the diagnosis and treatment of lung cancer within the context of lung cancer screening. Improved risk classification criteria and novel imaging approaches for screening populations are highly required as more than half of lung cancer cases are false positive during the initial screening round if the National Lung Screening Trial (NLST) demographic criteria [≥30 pack years (PY) of cigarettes, age ≥55 years] are applied...
August 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/27621851/ct-guided-microcoil-vats-resection-of-lung-nodules-a-single-centre-experience-and-review-of-the-literature
#14
Laura L Donahoe, Elsie T Nguyen, Tae-Bong Chung, Lan-Chau Kha, Marcelo Cypel, Gail E Darling, Marc de Perrot, Shaf Keshavjee, Andrew F Pierre, Thomas K Waddell, Kazuhiro Yasufuku
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is standard of care for small lung resections at many centres. Computed tomography (CT)-guided insertion of microcoils can aid surgeons in performing VATS resections for non-palpable lung nodules deep to the lung surface. METHODS: Retrospective analysis of CT-guided microcoil insertions prior to VATS lung resection at a single institution from October 2008 to January 2014. RESULTS: A total of 63 patients were included (37% male, mean age 61...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27606076/smoking-cessation-results-in-a-clinical-lung-cancer-screening-program
#15
Andrea K Borondy Kitts, Andrea B McKee, Shawn M Regis, Christoph Wald, Sebastian Flacke, Brady J McKee
BACKGROUND: Lung cancer screening may provide a "teachable moment" for promoting smoking cessation. This study assessed smoking cessation and relapse rates among individuals undergoing follow-up low-dose chest computed tomography (CT) in a clinical CT lung screening program and assessed the influence of initial screening results on smoking behavior. METHODS: Self-reported smoking status for individuals enrolled in a clinical CT lung screening program undergoing a follow-up CT lung screening exam between 1st February, 2014 and 31st March, 2015 was retrospectively reviewed and compared to self-reported smoking status using a standardized questionnaire at program entry...
July 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27599248/lung-cancer-screening-latest-developments-and-unanswered-questions
#16
REVIEW
Carlijn M van der Aalst, Kevin Ten Haaf, Harry J de Koning
The US National Lung Screening Trial showed that individuals randomly assigned to screening with low-dose CT scans had 20% lower lung cancer mortality than did those screened with conventional chest radiography. On the basis of a review of the literature and a modelling study, the US Preventive Services Task Force recommends annual screening for lung cancer for individuals aged 55-80 years who have a 30 pack-year smoking history and either currently smoke or quit smoking within the past 15 years. However, the balance between benefits and harms of lung cancer screening is still greatly debated...
September 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27579337/radiological-and-pathological-analysis-of-ldct-screen-detected-and-surgically-resected-sub-centimetre-lung-nodules-in-44-asymptomatic-patients
#17
Xing Hu, Jiangmin Zhao, Haishan Qian, Guangyan Du, Margaret Kelly, Hua Yang
PURPOSE: Once lung cancer is detected due to clinical symptoms or by being visible on chest X-ray, it is usually high stage and non-operable. In order to improve mortality rates in lung cancer, low-dose CT (LDCT) screening of "high risk" individuals is gaining popularity. However, the rate of malignancy in LDCT detected sub-centimetre lung nodules is not clear. We aimed to analyze surgically resected specimens in this patient group to explore cost effectiveness and recommendations for clinical management of these nodules...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27411917/-lung-cancer-screening-with-thoracic-x%C3%A2-ray-and-ct-current-situation
#18
O von Stackelberg, H-U Kauczor
CLINICAL/METHODICAL ISSUE: Attempts at the early detection of lung cancer using imaging methods began as far back as the 1950s. STANDARD RADIOLOGICAL METHODS: Several studies attempted to demonstrate a reduction of lung cancer mortality by chest radiography screening but all were unsuccessful. METHODICAL INNOVATIONS: Even the first small screening studies using computed tomography (CT) could not demonstrate a reduction in lung cancer-specific mortality until in 2011 the results of the largest randomized controlled low-dose CT screening study in the USA (NLST) were published...
September 2016: Der Radiologe
https://www.readbyqxmd.com/read/27398283/distant-metastasis-detected-by-routine-staging-in-breast-cancer-patients-participating-in-the-national-german-screening-programme-consequences-for-clinical-practice
#19
Peter Rusch, Oliver Hoffmann, Anna-L Stickelmann, Stephan Böhmer, Regine Gätje, Karl G Krüger, Stefan Niesert, Andrea Schmidt, Rainer Kimmig
PURPOSE: To determine frequency of routine radiological staging of breast cancer patients diagnosed in a German Breast Cancer Screening Center from 2007 to 2014, the incidence and consequences of distant metastases detected and the resulting implications for clinical routine. METHODS: Records of 896 patients with primary breast cancer diagnosed in the Screening Centre and treated in five participating hospitals were analyzed retrospectively. Evaluation included frequency and type of staging procedures and results with respect to distant metastasis and their consequences on clinical management...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27335294/-issues-relevant-to-surgical-intervention-in-tiny-non-small-cell-lung-cancer-detected-by-lung-screening-orientation-lung-resection-and-lymph-node-resection
#20
Deruo Liu, Zhenrong Zhang
With the widely application of chest computed tomography (CT) and gradual generalization of lung cancer screening project for high risk populations, more and more "tiny lung cancers" were identified. Due to the difficulty in intraoperative orientation, their less aggressiveness, and excellent short/long term prognosis, the 'tiny lung cancers' posed new challenges for the surgery in the treatment of lung cancer. In this review, theirfore, we focused on these challenges and presented the progress in lung cancer screening, orientation of lung nodules, lobectomy and sublobectomy, and lymph node dissection...
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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