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Chest CT for screening for lung cancer

Phan Tuong Huynh, Sergy V Lemeshko, Mary C Mahoney, Mary S Newell, Lisa Bailey, Lora D Barke, Carl D'Orsi, Jennifer A Harvey, Mary K Hayes, Peter M Jokich, Su-Ju Lee, Constance D Lehman, Martha B Mainiero, David A Mankoff, Samir B Patel, Handel E Reynolds, M Linda Sutherland, Bruce G Haffty
Stage I breast carcinoma is classified when an invasive breast carcinoma is ≤2 cm in diameter (T1), with no regional (axillary) lymph node metastases (N0) and no distant metastases (M0). The most common sites for metastases from breast cancer are the skeleton, lung, liver, and brain. In general, women and health care professionals prefer intensive screening and surveillance after a diagnosis of breast cancer. Screening protocols include conventional imaging such as chest radiography, bone scan, ultrasound of the liver, and MRI of brain...
November 2016: Journal of the American College of Radiology: JACR
O Leleu, M Auquier, O Carre, B Chauffert, A Dubreuil, V Petigny, B Trancart, P Berna, V Jounieaux
RATIONALE: This feasibility trial proposes to set up in the department of the Somme an annual screening for lung cancer with low-dose thoracic CT. It responds to the first objective of the third cancer plan and follows the publication of the results of the National Lung Screening Trial in 2011. METHODS: The method of this study is to use the existing networks among and between healthcare professionals and the departmental cancer screening structure. The inclusion criteria will be those of the National Lung Screening Trial...
October 12, 2016: Revue des Maladies Respiratoires
Zixing Wang, Yaoda Hu, Yuyan Wang, Wei Han, Lei Wang, Fang Xue, Xin Sui, Wei Song, Ruihong Shi, Jingmei Jiang
OBJECTIVES: To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there's universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach. MATERIALS AND METHODS: EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2...
2016: PloS One
Peter J Mazzone
Lung cancer screening with a low radiation dose chest CT scan has been shown to reduce the number of people, in a well-defined very high-risk cohort, who die from lung cancer. Many potential screening-related harms have been identified, including anxiety and morbidity related to the evaluation of screen-detected findings. A favorable balance of the benefit and harms of lung cancer screening requires careful implementation of a screening program, with a focus on several obstacles to the success of the program...
October 2016: Seminars in Respiratory and Critical Care Medicine
Chunxia Su, Mathias Meyer, Robert Pirker, Wieland Voigt, Jingyun Shi, Lothar Pilz, Rudolf M Huber, Yilong Wu, Jinghong Wang, Yonglan He, Xuan Wang, Jian Zhang, Xiuyi Zhi, Meiqi Shi, Bo Zhu, Stefan S Schoenberg, Thomas Henzler, Christian Manegold, Caicun Zhou, Eric Dominic Roessner
The first Chinese-German Lung Cancer Expert Panel was held in November 2015 one day after the 7th Chinese-German Lung Cancer Forum, Shanghai. The intention of the meeting was to discuss strategies for the diagnosis and treatment of lung cancer within the context of lung cancer screening. Improved risk classification criteria and novel imaging approaches for screening populations are highly required as more than half of lung cancer cases are false positive during the initial screening round if the National Lung Screening Trial (NLST) demographic criteria [≥30 pack years (PY) of cigarettes, age ≥55 years] are applied...
August 2016: Translational Lung Cancer Research
Laura L Donahoe, Elsie T Nguyen, Tae-Bong Chung, Lan-Chau Kha, Marcelo Cypel, Gail E Darling, Marc de Perrot, Shaf Keshavjee, Andrew F Pierre, Thomas K Waddell, Kazuhiro Yasufuku
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is standard of care for small lung resections at many centres. Computed tomography (CT)-guided insertion of microcoils can aid surgeons in performing VATS resections for non-palpable lung nodules deep to the lung surface. METHODS: Retrospective analysis of CT-guided microcoil insertions prior to VATS lung resection at a single institution from October 2008 to January 2014. RESULTS: A total of 63 patients were included (37% male, mean age 61...
August 2016: Journal of Thoracic Disease
Andrea K Borondy Kitts, Andrea B McKee, Shawn M Regis, Christoph Wald, Sebastian Flacke, Brady J McKee
BACKGROUND: Lung cancer screening may provide a "teachable moment" for promoting smoking cessation. This study assessed smoking cessation and relapse rates among individuals undergoing follow-up low-dose chest computed tomography (CT) in a clinical CT lung screening program and assessed the influence of initial screening results on smoking behavior. METHODS: Self-reported smoking status for individuals enrolled in a clinical CT lung screening program undergoing a follow-up CT lung screening exam between 1st February, 2014 and 31st March, 2015 was retrospectively reviewed and compared to self-reported smoking status using a standardized questionnaire at program entry...
July 2016: Journal of Thoracic Disease
Carlijn M van der Aalst, Kevin Ten Haaf, Harry J de Koning
The US National Lung Screening Trial showed that individuals randomly assigned to screening with low-dose CT scans had 20% lower lung cancer mortality than did those screened with conventional chest radiography. On the basis of a review of the literature and a modelling study, the US Preventive Services Task Force recommends annual screening for lung cancer for individuals aged 55-80 years who have a 30 pack-year smoking history and either currently smoke or quit smoking within the past 15 years. However, the balance between benefits and harms of lung cancer screening is still greatly debated...
September 2016: Lancet Respiratory Medicine
Xing Hu, Jiangmin Zhao, Haishan Qian, Guangyan Du, Margaret Kelly, Hua Yang
PURPOSE: Once lung cancer is detected due to clinical symptoms or by being visible on chest X-ray, it is usually high stage and non-operable. In order to improve mortality rates in lung cancer, low-dose CT (LDCT) screening of "high risk" individuals is gaining popularity. However, the rate of malignancy in LDCT detected sub-centimetre lung nodules is not clear. We aimed to analyze surgically resected specimens in this patient group to explore cost effectiveness and recommendations for clinical management of these nodules...
2016: European Journal of Radiology Open
O von Stackelberg, H-U Kauczor
CLINICAL/METHODICAL ISSUE: Attempts at the early detection of lung cancer using imaging methods began as far back as the 1950s. STANDARD RADIOLOGICAL METHODS: Several studies attempted to demonstrate a reduction of lung cancer mortality by chest radiography screening but all were unsuccessful. METHODICAL INNOVATIONS: Even the first small screening studies using computed tomography (CT) could not demonstrate a reduction in lung cancer-specific mortality until in 2011 the results of the largest randomized controlled low-dose CT screening study in the USA (NLST) were published...
September 2016: Der Radiologe
Peter Rusch, Oliver Hoffmann, Anna-L Stickelmann, Stephan Böhmer, Regine Gätje, Karl G Krüger, Stefan Niesert, Andrea Schmidt, Rainer Kimmig
PURPOSE: To determine frequency of routine radiological staging of breast cancer patients diagnosed in a German Breast Cancer Screening Center from 2007 to 2014, the incidence and consequences of distant metastases detected and the resulting implications for clinical routine. METHODS: Records of 896 patients with primary breast cancer diagnosed in the Screening Centre and treated in five participating hospitals were analyzed retrospectively. Evaluation included frequency and type of staging procedures and results with respect to distant metastasis and their consequences on clinical management...
2016: SpringerPlus
Deruo Liu, Zhenrong Zhang
With the widely application of chest computed tomography (CT) and gradual generalization of lung cancer screening project for high risk populations, more and more "tiny lung cancers" were identified. Due to the difficulty in intraoperative orientation, their less aggressiveness, and excellent short/long term prognosis, the 'tiny lung cancers' posed new challenges for the surgery in the treatment of lung cancer. In this review, theirfore, we focused on these challenges and presented the progress in lung cancer screening, orientation of lung nodules, lobectomy and sublobectomy, and lymph node dissection...
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Zhihua Qi, Lisa C Lemen, Michael Lamba, Hua-Hsuan Chen, Ranasinghage Samaratunga, Mary Mahoney, R Edward Hendrick
RATIONALE AND OBJECTIVES: This work aimed to study the effects of scanner model and study protocol on radiation dose received by breast tissues from 64-slice computed tomography (CT) studies. MATERIALS AND METHODS: Four scanner models and three study protocols were used in scanning an anthropomorphic phantom with breast modules. Each protocol follows recommendations or guidelines from the American Association of Physicists in Medicine and the American College of Radiology...
August 2016: Academic Radiology
Jeon-Hor Chen, Siwa Chan, Nan-Han Lu, Yifan Li, Yu Chieh Tsai, Po Yun Huang, Chia-Ju Chang, Min-Ying Su
RATIONALE AND OBJECTIVES: Low-dose chest computed tomography (LDCT), increasingly being used for screening of lung cancer, may also be used to measure breast density, which is proven as a risk factor for breast cancer. In this study, we developed a segmentation method to measure quantitative breast density on CT images and correlated with magnetic resonance density. MATERIALS AND METHODS: Forty healthy women receiving both LDCT and breast magnetic resonance imaging (MRI) were studied...
September 2016: Academic Radiology
Lukas Ebner, Justus E Roos, Jared D Christensen, Tomas Dobrocky, Lars Leidolt, Barbara Brela, Verena C Obmann, Sonya Joy, Adrian Huber, Andreas Christe
OBJECTIVE: The objective of our study was to evaluate lung nodule detection rates on standard and microdose chest CT with two different computer-aided detection systems (SyngoCT-CAD, VA 20, Siemens Healthcare [CAD1]; Lung CAD, IntelliSpace Portal DX Server, Philips Healthcare [CAD2]) as well as maximum-intensity-projection (MIP) images. We also assessed the impact of different reconstruction kernels. MATERIALS AND METHODS: Standard and microdose CT using three reconstruction kernels (i30, i50, i70) was performed with an anthropomorphic chest phantom...
August 2016: AJR. American Journal of Roentgenology
John K Field, Stephen W Duffy, David R Baldwin, Kate E Brain, Anand Devaraj, Tim Eisen, Beverley A Green, John A Holemans, Terry Kavanagh, Keith M Kerr, Martin Ledson, Kate J Lifford, Fiona E McRonald, Arjun Nair, Richard D Page, Mahesh Kb Parmar, Robert C Rintoul, Nicholas Screaton, Nicholas J Wald, David Weller, David K Whynes, Paula R Williamson, Ghasem Yadegarfar, David M Hansell
BACKGROUND: Lung cancer kills more people than any other cancer in the UK (5-year survival < 13%). Early diagnosis can save lives. The USA-based National Lung Cancer Screening Trial reported a 20% relative reduction in lung cancer mortality and 6.7% all-cause mortality in low-dose computed tomography (LDCT)-screened subjects. OBJECTIVES: To (1) analyse LDCT lung cancer screening in a high-risk UK population, determine optimum recruitment, screening, reading and care pathway strategies; and (2) assess the psychological consequences and the health-economic implications of screening...
May 2016: Health Technology Assessment: HTA
Darragh F Halpenny, Jane D Cunningham, Niamh M Long, Ramon E Sosa, Michelle S Ginsberg
INTRODUCTION: The aim of this study was to describe the clinical characteristics and radiologic findings in patients with a previous history of malignancy who underwent computed tomography (CT) screening for lung cancer. METHODS: Patients with a previous history of malignancy and a life expectancy of at least 5 years who were referred for lung cancer screening between May 2, 2011, and September 24, 2014, were included. CT scan features assessed included nodule size, morphologic features, and number...
September 2016: Journal of Thoracic Oncology
Natalia Saltybaeva, Katharina Martini, Thomas Frauenfelder, Hatem Alkadhi
PURPOSE: Lung cancer screening with CT has been recently recommended for decreasing lung cancer mortality. The radiation dose of CT, however, must be kept as low as reasonably achievable for reducing potential stochastic risks from ionizing radiation. The purpose of this study was to calculate individual patients' lung doses and to estimate cancer risks in low-dose CT (LDCT) in comparison with a standard dose CT (SDCT) protocol. MATERIALS AND METHODS: This study included 47 adult patients (mean age 63...
2016: PloS One
Felix Jf Herth, Ralf Eberhardt, Maren Schuhmann
INTRODUCTION: More than 150,000 solitary pulmonary nodules are reported each year in the United States. As the popularity of low dose CT scan use for screening grows, these numbers are likely to increase substantially over the coming years. More than 10 million CT scans of the chest were performed in the United States alone in 2012, highlighting the potential for this clinical scenario. Detecting a nodule on either a chest radiograph or a CT scan frequently leads to a cascade of further investigations to establish a definite diagnosis...
August 2016: Expert Review of Respiratory Medicine
Joseph Shemesh
The recent acceptance of low dose chest computed tomography (LDCT) as a screening modality for early lung cancer detection will significantly increase the number of LDCT among high risk population. The target subjects are at the same time at high risk to develop cardiovascular (CV) events. The routine report on coronary artery calcification (CAC) will therefore, enhances the screening benefit by providing the clinicians with an additive powerful risk stratification tool for the management or primary prevention of CV events...
April 2016: Annals of Translational Medicine
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