keyword
https://read.qxmd.com/read/38352811/diffuse-b-cell-lymphoma-of-the-mandible-disguised-as-acute-osteomyelitis
#21
JOURNAL ARTICLE
Devina Adalja, Ariana Tagliaferri, Abraam Rezkalla, Basil Taha
BACKGROUND: Primary bone lymphoma (PBL) is a rare form of extra nodal non-Hodgkin's lymphoma (NHL). CASE DESCRIPTION: We describe a 39-year-old-male with no medical history who presented with unilateral facial swelling following a tooth extraction. Initial diagnoses after various presentations over the course of three weeks, based on inflammatory and infectious aetiologies. However, the patient was ultimately diagnosed with diffuse large B-cell lymphoma. DISCUSSION: Symptoms of PBL are very similar to inflammatory and infectious diseases of the bone, such as osteomyelitis or osteonecrosis...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38336230/which-trial-do-we-need-empiric-glycopeptides-plus-clindamycin-versus-oxazolidinones-for-suspected-toxic-shock-and-necrotizing-soft-tissue-infections-toxic-ego
#22
JOURNAL ARTICLE
Joshua Osowicki, Fergus Hamilton, Todd C Lee, Michael Marks, Erin K McCreary, Emily G McDonald, Jonathan H Ryder, Steven Yc Tong
No abstract text is available yet for this article.
February 7, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38324002/increase-in-streptococcal-necrotizing-fasciitis-during-and-after-the-coronavirus-disease-2019-pandemic
#23
JOURNAL ARTICLE
David Breidung, Moritz Billner, Ioannis-Fivos Megas, Alejandro Marti Edo, Bert Reichert, Asja T Malsagova
Background: Necrotizing fasciitis (NF) is a life-threatening and rare condition. However, we report and analyze a remarkably high number of NF cases during the coronavirus disease 2019 (COVID-19) pandemic and especially in the first months after the COVID-19 pandemic. Patients and Methods: We conducted a retrospective analysis of 17 cases of NF treated in our clinic between January and May 2023. Data were collected on demographics, comorbidities, risk factors, laboratory findings, and clinical outcomes. For each individual case two risk indicating scores, the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) and Laboratory and Anamnestic Risk Indicator for Necrotizing Fasciitis (LARINF) were calculated...
February 6, 2024: Surgical Infections
https://read.qxmd.com/read/38320324/term-neonate-born-with-right-upper-extremity-skin-necrosis-at-birth-a-case-report
#24
JOURNAL ARTICLE
Ashajyothi M Siddappa, Likhita Shaik, Tina Slusher, Jon Gayken, Ashley Bjorklund
Congenital skin and soft tissue necrosis is a rare condition associated with significant morbidity and mortality in neonates. The authors treated a neonate born with significant skin necrosis of the right forearm. The case report is followed by a literature review and discussion of previously published reports of neonatal skin necrosis. A term female neonate was admitted to our hospital at 24 hours of age for skin necrosis of right forearm with sloughing and edema below the right elbow and contractures of her fingers...
February 6, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://read.qxmd.com/read/38315508/identification-of-potentially-modifiable-factors-to-improve-recognition-and-outcome-of-necrotizing-soft-tissue-infections
#25
JOURNAL ARTICLE
Jaco Suijker, Anouk Pijpe, Denise Hoogerbrug, Martijn W Heymans, Paul P M van Zuijlen, Jens A Halm, Annebeth Meij-de Vries
BACKGROUND: Necrotizing Soft-Tissue Infections (NSTI) present a surgical emergency of increasing incidence, which is often misdiagnosed, and associated with substantial mortality and morbidity. A retrospective multicentre (11 hospitals) cohort study was initiated to identify the early predictors of misdiagnosis, mortality, and morbidity (skin defect size and amputation). METHODS: Patients of all ages who presented with symptoms and were admitted for acute treatment of NSTI between January 2013 and December 2017 were included...
February 2, 2024: Shock
https://read.qxmd.com/read/38310788/fournier-s-gangrene-with-streptococcus-anginosus-in-the-setting-of-hidrandenitis-suppurativa-perineal-abscess-a-case-report
#26
Andreas Lau, Nobel Nguyen, Alvin Hui, Johnson Ong, Michael Salehpour
INTRODUCTION: Fournier's gangrene is a rare but life-threatening form of necrotizing soft tissue infection involving the perineal, genital, or perianal region, commonly caused by a mix of aerobic and anaerobic organisms. Initially discovered in dental abscesses, Streptococcus anginosus have been increasingly reported in pyogenic and systemic infections with abscess formation. We present a rare case of perineal abscess that developed into Fournier's gangrene in which the causative pathogen isolated was S...
January 28, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38296509/alt-in-combination-with-triple-rolled-tfl-for-reconstruction-of-a-complex-tendoachilles-defect-technical-details-and-rehabilitation-regime
#27
JOURNAL ARTICLE
Zahra Ahmed, Hannah Cook, Meera Anadkat, Lydia Ioannidi, Helen Marmery, Dariush Nikkhah
A fit man in his 60s presented with an infected Achilles tendon (AT) following two failed repairs for a traumatic rupture. Initial debridement of necrotic tissue resulted in a large soft tissue defect requiring robust coverage. Following aggressive wound management, an anterolateral thigh flap was elevated with tensor fasciae latae (TFL) which was triple-rolled to provide soft tissue coverage and tendon reconstruction.The flap remained healthy and was monitored with a flow coupler device. Initially, the foot was placed in plantarflexion before gradually increasing the angle to neutral and a thermoplastic splint was used to offload pressure on the flap...
January 31, 2024: BMJ Case Reports
https://read.qxmd.com/read/38286885/clinical-and-molecular-epidemiological-features-of-critically-ill-patients-with-invasive-group-a-streptococcus-infections-a-belgian-multicenter-case-series
#28
JOURNAL ARTICLE
Marijke Peetermans, Veerle Matheeussen, Cedric Moerman, Fréderic De Rydt, Sabine Thieren, Emily Pollet, Michael Casaer, Benjamin De Backer, Rudi De Paep, Yves Debaveye, Lars Desmet, Stefanie Desmet, Els I M Duval, Vincent Fraipont, Dieter Geysels, Greet Hermans, Frederik Lahaye, Xavier Mathy, Philippe Meersseman, Cécile Meex, Jozef Van Herck, Stefanie van Kleef-van Koeveringe, Nathalie Layios, Joost Wauters, Philippe G Jorens
BACKGROUND: Recent alerts have highlighted an increase in group A streptococcal (GAS) infections since 2022 in Europe and the United States. Streptococcus pyogenes can cause limited skin or mucosal disease, but can also present as severe invasive disease necessitating critical care. We performed a multicenter retrospective study of patients with GAS infections recently admitted to Belgian intensive care units (ICUs) since January 2022. We describe patient characteristics and investigate the molecular epidemiology of the S...
January 29, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38285994/dilute-povidone-iodine-solution-soaking-is-ineffective-in-improving-outcomes-of-necrotizing-fasciitis-caused-by-diabetic-foot
#29
JOURNAL ARTICLE
Wen-Yu Lin, Chun-Yu Ma, Wei-Chieh Fang, Tien-Hsiang Wang, Yu-Chung Shih, Chih-Hsun Lin, Szu-Hsien Wu, Cherng-Kang Perng, Ching-En Chen
Wound soaking is a physical debridement method that helps reduce bacterial colonization and consequently promotes wound healing. Although soaking in povidone-iodine solution was ineffective in reducing bacterial colonization in acute trauma wounds, there is still a lack of evidence supporting the efficacy of this method in treating severe soft tissue infection. This study aimed to explore the effects of wound soaking in 1% dilute povidone-iodine solution on necrotizing fasciitis caused by diabetic foot ulcers...
January 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38283521/necrotizing-fasciitis-in-a-patient-with-signet-ring-cell-gastric-adenocarcinoma
#30
Lorenz Kristoffer Daga, Lovell Gatchalian
Necrotizing fasciitis is an aggressive infection of the skin and soft tissues that requires prompt recognition and management. Immediate source control and adjunctive antibiotic therapy are the cornerstones of management. There are limited reported cases of necrotizing fasciitis related to gastrointestinal malignancy, including gastric cancer. This report describes the case of a 36-year-old male who developed left abdominal wall necrotizing fasciitis related to perforated gastric adenocarcinoma with signet-ring features...
December 2023: Curēus
https://read.qxmd.com/read/38283469/a-narrative-review-of-osteonecrosis-of-the-jaw-what-a-clinician-should-know
#31
REVIEW
Swati Sharma, Rama Shankar, B Sarat Ravi Kiran, Rohit Breh, Shitun Sarangi, Amitabh Kumar Upadhyay
Medication-related osteonecrosis of the jaw (MRONJ) is an uncommon complication of antiresorptive therapy (ART) in patients receiving higher and more frequent doses of osteoclast inhibitors. The jaws are the most common site, as they have high bone turnover. The oral structures are exposed to various types of stresses, like mastication and dental diseases, which lead to microtrauma and increased bone remodeling. The hallmark feature of MRONJ is the area of exposed, necrotic, nonhealing, asymptomatic bone for more than eight weeks...
December 2023: Curēus
https://read.qxmd.com/read/38282815/mucormycosis-cytomorphological-spectrum-in-fine-needle-aspiration-cytology
#32
JOURNAL ARTICLE
Malvika Shastri, Radhika Srinivasan, Reetu Kundu, Pranab Dey, Nalini Gupta, Parikshaa Gupta, Manish Rohilla, Mandeep Kang, Naveen Kalra, Harsimran Kaur, Shivaprakash M Rudramurthy
BACKGROUND: Mucormycosis is a fungal infection that can affect multiple organs. The role of fine-needle aspiration cytology (FNAC) in its diagnosis is not well documented. AIM: The objective of this study was to describe the detailed cytomorphologic features of mucormycosis on FNAC samples. MATERIALS AND METHODS: A retrospective analysis of all cases diagnosed as mucormycosis on FNAC between January 2014 and July 2021 was performed for detailed cytomorphological evaluation and correlation to clinical data and microbiological studies wherever available...
2024: Journal of Cytology
https://read.qxmd.com/read/38268169/first-report-of-brown-rot-caused-by-porogramme-epimiltina-on-gastrodia-elata-in-china
#33
JOURNAL ARTICLE
Jian Zhao, Liqiong Cai, Shunqiang Yang, Jiayun Miao, Changlin Zhao
Gastrodia elata Blume is a valuable medicinal plant in China with great significance in medicine (Li et al. 2023). From 2022 to 2023, G. elata tuber rot occurred in about 50 households in the main cultivation areas of G. elata (27°39' N, 104°16' E) in Yiliang County, Zhaotong, Yunnan Province, southwest China. The planting area of G. elata was 776 ha, and the incidence rate was 10%. Symptoms present as light brown lesions on the surface of the tuber, sunken, soft and foul-smelling. Infected G. elata tubers were randomly collected from each household, packed into transparent plastic bags, and strains were isolated in the laboratory as follows...
January 24, 2024: Plant Disease
https://read.qxmd.com/read/38263617/diagnostic-accuracy-of-eosinophil-to-lymphocyte-ratio-and-eosinophil-to-neutrophil-ratio-as-biomarkers-for-differentiating-between-fungal-and-bacterial-infection-in-necrotising-otitis-externa
#34
JOURNAL ARTICLE
Benyamin M Kaminer, Sabri El-Saied, Batel Lasry, Daniel M Kaplan
INTRODUCTION: Necrotizing otitis externa (NOE) is a serious, progressive, and potentially life-threatening infection of the external auditory canal, affecting soft tissue and bone. The most common organism causing NOE is Pseudomonas Aeruginosa and less common are Fungal infections. When managing a patient with NOE, a culture is taken from the EAC in order to tailor the appropriate antimicrobial treatment, however commonly, the culture is sterile. Inflammation biomarkers may be used as adjuncts to inform on the differential diagnosis and as prognostic markers...
January 23, 2024: Clinical Otolaryngology
https://read.qxmd.com/read/38253724/no-role-for-standard-imaging-workup-of-patients-with-clinically-evident-necrotizing-soft-tissue-infections-a-national-retrospective-multicenter-cohort-study
#35
JOURNAL ARTICLE
Sanne R Brands, Femke Nawijn, Wouter Foppen, Falco Hietbrink
PURPOSE: To assess the diagnostic contribution of different imaging studies to diagnose necrotizing soft tissue infections (NSTIs) and the time to surgery in relation to imaging with the hypothesis that imaging studies may lead to significant delays without being able to sufficiently dismiss or confirm the diagnosis since a NSTI is a surgical diagnosis. METHODS: A retrospective multicenter cohort study of all NSTI patients between 2010 and 2020 was conducted. The primary outcome was the number of cases in which imaging contributed to or led to change in treatment...
January 23, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38252202/genotypic-characterization-of-hypervirulent-klebsiella-pneumoniae-hvkp-in-a-tertiary-care-indian-hospital
#36
JOURNAL ARTICLE
Birasen Behera, Pragyan Paramita Swain, Bidyutprava Rout, Rajashree Panigrahy, Rajesh Kumar Sahoo
Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathogen and causes endophthalmitis, liver abscess, osteomyelitis, meningitis, and necrotizing soft tissue infections in both immunodeficient and healthy people. The acquisition of the antibiotic resistance genes of hvKp has become an emerging concern throughout the globe. In this study, a total of 74 K. pneumoniae isolates were collected and identified by VITEK2 and blaSHV  gene amplification. Out of these, 18.91% (14/74) isolates were identified as hvKp by both phenotypic string test and genotypic iucA PCR amplification...
January 22, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38250213/practical-review-of-necrotizing-fasciitis-principles-and-evidence-based-management
#37
REVIEW
Gunel Guliyeva, Maria T Huayllani, Nishant T Sharma, Jeffrey E Janis
Necrotizing fasciitis is a severe, life-threatening soft tissue infection that presents as a surgical emergency. It is characterized by a rapid progression of inflammation leading to extensive tissue necrosis and destruction. Nonetheless, the diagnosis might be missed or delayed due to variable and nonspecific clinical presentation, contributing to high mortality rates. Therefore, early diagnosis and prompt, aggressive medical and surgical treatment are paramount. In this review, we highlight the defining characteristics, pathophysiology, diagnostic modalities, current principles of treatment, and evolving management strategies of necrotizing fasciitis...
January 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38247655/toxic-shock-syndrome-a-literature-review
#38
REVIEW
Enora Atchade, Christian De Tymowski, Nathalie Grall, Sébastien Tanaka, Philippe Montravers
Toxic shock syndrome (TSS) is a rare, life-threatening, toxin-mediated infectious process linked, in the vast majority of cases, to toxin-producing strains of Staphylococcus aureus or Streptococcus pyogenes . The pathophysiology, epidemiology, clinical presentation, microbiological features, management and outcome of TSS are described in this review. Bacterial superantigenic exotoxins induces unconventional polyclonal lymphocyte activation, which leads to rapid shock, multiple organ failure syndrome, and death...
January 18, 2024: Antibiotics
https://read.qxmd.com/read/38244060/lower-extremity-infections-essential-anatomy-and-multimodality-imaging-findings
#39
REVIEW
George R Matcuk, Matthew R Skalski, Dakshesh B Patel, Brandon K K Fields, Leah E Waldman, Paolo Spinnato, Ali Gholamrezanezhad, Sanaz Katal
In modern practice, imaging plays an integral role in the diagnosis, evaluation of extent, and treatment planning for lower extremity infections. This review will illustrate the relevant compartment anatomy of the lower extremities and highlight the role of plain radiographs, CT, US, MRI, and nuclear medicine in the diagnostic workup. The imaging features of cellulitis, abscess and phlegmon, necrotizing soft tissue infection, pyomyositis, infectious tenosynovitis, septic arthritis, and osteomyelitis are reviewed...
January 20, 2024: Skeletal Radiology
https://read.qxmd.com/read/38238240/risk-model-for-predicting-mortality-in-patients-with-necrotizing-soft-tissue-infections-in-the-intensive-care-unit
#40
JOURNAL ARTICLE
Lu-Yao Zhang, Zhi-Min Qiu, Guang-Ju Zhao, Pin-Pin Jin, Long-Wang Chen, Ya-Hui Tang, Guang-Liang Hong, Zhong-Qiu Lu, Wei-Jie Zheng, Ke Li, JianPing-Ye
BACKGROUND: The goal of this study is to look into the factors that lead to death in patients with necrotizing soft tissue infections(NSTIs) in the intensive care unit and create a mortality risk model. METHODS: The clinical data of 106 patients with necrotizing soft tissue infections admitted to intensive care unit(ICU) of the First Affiliated Hospital of Wenzhou Medical University between January 2008 and December 2021 were retrospectively analyzed...
December 1, 2023: Burns
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