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Necrotizing soft tissue infection

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https://www.readbyqxmd.com/read/29667040/management-of-superficial-and-deep-seated-staphylococcus-aureus-skin-and-soft-tissue-infections-in-sub-saharan-africa-a-post-hoc-analysis-of-the-staphnet-cohort
#1
Abraham Alabi, Theckla Kazimoto, Marthe Lebughe, Delfino Vubil, Patrick Phaku, Inacio Mandomando, Winfried V Kern, Salim Abdulla, Alexander Mellmann, Lena Peitzmann, Markus Bischoff, Georg Peters, Mathias Herrmann, Martin P Grobusch, Frieder Schaumburg, Siegbert Rieg
PURPOSE: The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in the African setting and to identify challenges in the management. METHODS: Patients (n = 319) were recruited in DR Congo (n = 56, 17.6%), Gabon (n = 89, 27...
April 17, 2018: Infection
https://www.readbyqxmd.com/read/29661109/prevalence-and-risk-factors-for-methicillin-resistant-staphylococcus-aureus-mrsa-infections-in-custodial-populations-a-systematic-review
#2
Leigh Haysom, Melanie Cross, Rebecca Anastasas, Elizabeth Moore, Stephen Hampton
Methicillin-resistant Staphylococcus aureus (MRSA) in prisons can result in serious morbidity and death. We reviewed rates and risk factors for MRSA infection in custody, searching Medline, EMBASE, and CINAHL databases. Between 1997 and 2015, 17 studies reported MRSA skin and soft tissue infections (SSTIs), with four case reports of MRSA non-SSTI (necrotizing pneumonias, brain abscess, and epiduritis). Significant associations with MRSA SSTI were found: MRSA colonization, previous skin infection, sharing soap or personal items, SSTI presenting as an abscess or furuncle, younger age, non-Caucasian, overweight, communal laundering, infrequent handwashing, lower hygiene score...
April 2018: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/29652296/validation-of-the-aast-egs-grade-for-skin-and-soft-tissue-infection
#3
Mohamed D Ray-Zack, Matthew C Hernandez, Moustafa Younis, Wyatt B Hoch, Dylan S Soukup, Nadeem Haddad, Martin D Zielinski
INTRODUCTION: Skin and soft tissue infections (SSTI) present with variable severity. The American Association for the Surgery of Trauma (AAST) developed an emergency general surgery (EGS) grading system for several diseases. We aimed to determine whether the AAST EGS grade corresponds with key clinical outcomes. METHODS: Single institution retrospective review of patients (≥18 years) admitted with SSTI during 2012-2016 was performed. Patients with surgical site infections or <18 years were excluded...
February 27, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29629439/the-dentist-s-role-in-the-prevention-and-management-of-necrotizing-stomatitis-in-the-immunosuppressed
#4
Mahnaz Fatahzadeh
Advances in transplant medicine and availability of effective immunosuppressive regimens have dramatically improved survival for patients afflicted with end-stage organ failure. However, chronic immunosuppression predisposes transplant patients to infection caused by a wide spectrum of endogenous or exogenous pathogens as well as necrotizing periodontal conditions. This article reviews clinical features, diagnosis, and management of necrotizing stomatitis in the context of therapeutic immunosuppression and discusses the integral function of dentists in eliminating oral foci of infection in preparation for transplantation as well as life-long maintenance of oral health post-transplant...
2018: Quintessence International
https://www.readbyqxmd.com/read/29627916/necrotizing-fasciitis-case-series-and-review-of-the-literature-on-clinical-and-medico-legal-diagnostic-challenges
#5
Paolo Fais, Alessia Viero, Guido Viel, Renzo Giordano, Dario Raniero, Stefano Kusstatscher, Chiara Giraudo, Giovanni Cecchetto, Massimo Montisci
Necrotizing fasciitis (NF) is a life-threatening infection of soft tissues spreading along the fasciae to the surrounding musculature, subcutaneous fat and overlying skin areas that can rapidly lead to septic shock and death. Due to the pandemic increase of medical malpractice lawsuits, above all in Western countries, the forensic pathologist is frequently asked to investigate post-mortem cases of NF in order to determine the cause of death and to identify any related negligence and/or medical error. Herein, we review the medical literature dealing with cases of NF in a post-mortem setting, present a case series of seven NF fatalities and discuss the main ante-mortem and post-mortem diagnostic challenges of both clinical and forensic interests...
April 7, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29600128/fatal-necrotizing-myositis-from-fulminant-streptococcus-dysgalactiae-subspecies-equisimilis-sdse-infection-a-case-report-of-autopsy-images
#6
Manabu Izumi, Taku Hiraiwa, Hideto Tomioka, Masayoshi Komura, Yasushi Hayashi
Over the past few decades, Streptococcus dysgalactiae subspecies equisimilis (SDSE) have been considered as weak pathogenicity compared with S. pyogenes (GAS). Some recent reports argue that SDSE may bring severe soft tissue infection as same as GAS. No reports have been tried to reveal the clinical characteristics and autopsy images of fulminant SDSE infection. In this case report, we aimed to present a case of fatal necrotizing myositis from fulminant SDSE infection at iliopsoas, including autopsy appearance...
March 2018: Journal of General and Family Medicine
https://www.readbyqxmd.com/read/29595103/application-of-medicinal-plants-as-a-source-for-therapeutic-agents-against-streptococcus-pyogenes-infections
#7
Adil Mohd, H P Vasantha Rupasinghe
Streptococcus pyogenes, a major human pathogen, causes a wide variety of invasive systemic infections such as acute pharyngitis, skin and soft-tissue infections, especially necrotizing fasciitis. This Gram-positive bacterium has an ability to form mature biofilm and this sessile lifestyle plays an important role in S. pyogenes pathogenicity. The virulence of these bacteria is further strengthened by its ability to communicate within the micro-colonies through quorum sensing. Most treatments are now aimed at either elimination of this bacterium or suppression of its virulence...
March 29, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29588065/atypical-presentation-of-escherichia-coli-monomicrobial-necrotizing-fasciitis-in-a-renal-transplant-patient-a-case-report
#8
S Afghani, V Ngo, T Khan, V Lewis
Skin and soft tissue infections (SSTIs) are one of most frequent infectious causes for referral to the emergency department and one of the most frequent infectious causes of hospital admissions. Escherichia coli, the most commonly occurring gram-negative pathogen involved in these infections, contributes to about 7% of all SSTIs cases where gram-positive organisms reign dominant. Patients are more susceptible to these gram-negative SSTIs if they are neutropenic, have hematologic malignancies, have undergone solid organ or hematopoietic transplantation, or have cirrhotic liver disease...
March 24, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29570912/a-case-of-severe-soft-tissue-infection-due-to-streptococcus-tigurinus-diagnosed-by-necropsy-in-which-genomic-analysis-was-useful-for-clarifying-its-pathogenicity
#9
Hidenori Yoshizawa, Daisuke Motooka, Yuki Matsumoto, Ryuichi Katada, Shota Nakamura, Eiichi Morii, Tetsuya Iida, Hiroshi Matsumoto
Post-mortem detection of pathogenetic microorganisms in severe infectious death is significantly important for diagnosing the cause of death as well as for public health. However, it is difficult to recognize whether a microorganism detected from post-mortem materials is truly pathogenic or not. We report a case of severe soft tissue infection due to Streptococcus oralis subsp. tigurinus (S. tigurinus), a recently reported species, in which whole-genome analysis was performed to clarify its pathogenicity. A 46-year-old woman had died with symptoms of a severe infectious disease...
March 23, 2018: Pathology International
https://www.readbyqxmd.com/read/29559069/retroperitoneal-necrotizing-soft-tissue-infection-presenting-as-a-concern-for-missed-hollow-viscus-injury
#10
James G Malcolm, Elizabeth D Fox, Christopher J Dente, Dipan C Patel
No abstract text is available yet for this article.
March 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29521041/computerized-planimetry-evaluation-of-hyperbaric-oxygen-therapy-in-the-treatment-of-diabetic-foot
#11
Marek Kawecki, Jarosław Pasek, Grzegorz Cieślar, Aleksander Sieroń, Grzegorz Knefel, Mariusz Nowak, Justyna Glik
BACKGROUND: Diabetic foot ulcer is one of the major complications of diabetes mellitus in adults. OBJECTIVES: The aim of the study was to conduct a planimetry evaluation of the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of patients with vascular disorders caused by diabetic foot. MATERIAL AND METHODS: The study included 94 patients, 30 females (32%) and 64 males (68%), aged 33-76 years, with diabetes lasting 1.5-32 years, who underwent HBOT due to diabetic foot...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29520265/protein-sic-secreted-from-streptococcus-pyogenes-forms-complexes-with-extracellular-histones-that-boost-cytokine-production
#12
Johannes Westman, Bhavya Chakrakodi, Johanna Snäll, Matthias Mörgelin, Martin Bruun Madsen, Ole Hyldegaard, Ariane Neumann, Inga-Maria Frick, Anna Norrby-Teglund, Lars Björck, Heiko Herwald
Innate immunity relies on an effective recognition of the pathogenic microorganism as well as on endogenous danger signals. While bacteria in concert with their secreted virulence factors can cause a number of inflammatory reactions, danger signals released at the site of infection may in addition determine the amplitude of such responses and influence the outcome of the disease. Here, we report that protein SIC, Streptococcal Inhibitor of Complement, an abundant secreted protein from Streptococcus pyogenes , binds to extracellular histones, a group of danger signals released during necrotizing tissue damage...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29503165/factors-predicting-health-related-quality-of-life-following-necrotizing-fasciitis
#13
J P Gawaziuk, R Strazar, N Cristall, S Logsetty
BACKGROUND: Necrotizing fasciitis (NF) is a debilitating soft tissue infection that results in disfiguring scars and often amputations. While mortality rates have improved, long-term outcomes in survivors of NF are poorly understood. OBJECTIVES: The objective of this study is to analyze the impact of NF on survivors' health-related quality of life (HRQoL) influenced by age, sex, comorbidities, %TBSA, and confidence with appearance. METHODS: We surveyed 56 adult patients with NF treated at either of two regional referral centers in Manitoba, Canada, between January 1, 2004, and December 31, 2014...
February 14, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29485428/optimal-timing-of-initial-debridement-for-necrotizing-soft-tissue-infection-a-practice-management-guideline-from-the-eastern-association-for-the-surgery-of-trauma
#14
Rondi B Gelbard, Paula Ferrada, D Dante Yeh, Brian Williams, Michele Loor, James Yon, Caleb Mentzer, Kosar Khwaja, Mansoor Khan, Anirudh Kohli, Eileen M Bulger, Bryce R H Robinson
BACKGROUND: Necrotizing soft tissue infections (NSTI) are rare, life-threatening, soft-tissue infections characterized by rapidly spreading inflammation and necrosis of the skin, subcutaneous fat, and fascia. While it is widely accepted that delay in surgical debridement contributes to increased mortality, there are currently no practice management guidelines regarding the optimal timing of surgical management of this condition. Although debridement within 24 hours of diagnosis is generally recommended, the time ranges from 3 hours to 36 hours in the existing literature...
February 27, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29482707/hydatid-cyst-of-skeletal-muscle-presenting-as-soft-tissue-tumour
#15
Ayesha Mughal, Muhammad Saeed Minhas, Anisuddin Bhatti, Farooq Ahmed Moghul, Muhammad Muzzammil Sangani, Kashif Mehmood Khan, Afaq Alam, Mukesh Kumar, Amna Mughal
Hydatid disease is helminthic infection caused by tape worm echinococcus granulosis. It commonly involves liver (65-75%) and the lungs (25 to 30%). Involvement of bones and skeletal muscle is very rare, i.e. 3 to 5%. This is the report of a 21-year girl, city resident, presented with mass involving left proximal thigh. The mass was painless and had gradually increased in size over three years. MRI revealed solid cum cystic lesion in vastus medialis muscle. Tru-Cut needle biopsy of the lesion revealed necrotic material...
March 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29476307/paracoccidioides-brasiliensis-infection-mimicking-recurrent-hodgkin-lymphoma-a-case-report-and-review-of-the-literature
#16
Ayaz Ghani, Molly Weinberg, Nusrat Pathan, Ramapriya Vidhun, Steven Sieber
Paracoccidioides infection is a rare entity in the USA. This dimorphic fungus is found in Central and South America and is thought to be acquired by inhalation through the soil. We report a case of Paracoccidioides brasiliensis infection presenting as a clavicular bone lesion, peripancreatic mass, and various skin lesions. A 35-year-old man with a history significant for Hodgkin lymphoma presented with a left clavicular mass that was suspected clinically and radiologically as recurrent Hodgkin lymphoma. He was not experiencing any associated symptoms and was undergoing chemotherapy treatment for his known Hodgkin disease...
February 23, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29475402/progressive-subcutaneous-emphysema-of-unknown-origin-a-surgical-dilemma
#17
Lynn De Roeck, Lauranne Van Assche, Veronique Verhoeven, Ina Vrints, Jana Van Thielen, Thierry Tondu, Filip Thiessen
OBJECTIVE: Subcutaneous emphysema can be an alarming sign of a necrotizing soft tissue infection. However, non-infectious etiologies exist that can be treated conservatively. This case report describes a subcutaneous emphysema of unknown origin and highlights the importance of distinguishing these clinical entities. METHODS: We present a 17-year old female with pain and subcutaneous emphysema of the left arm. There were no systemic symptoms. Inflammatory parameters were slightly elevated...
February 23, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29428033/definitive-wound-closure-techniques-in-fournier-s-gangrene
#18
Margaret Lauerman, Olga Kolesnik, Habeeba Park, Laura S Buchanan, William Chiu, Ronald B Tesoriero, Deborah Stein, Thomas Scalea, Sharon Henry
Necrotizing soft tissue infection of the perineum, or Fournier's gangrene (FG), is a morbid and mortal diagnosis. Despite the severity of FG, the optimal definitive wound closure strategy is unknown, as are long-term wound outcomes. A retrospective review was performed over a 3-year period at a single trauma center. Patients were managed according to our institutional approach focusing on primary wound closure and secondary intention healing in residual wounds. Overall 168 patients were included. Complete primary wound closure was accomplished in 39...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29424798/group-b-streptococcal-cellulitis-and-necrotizing-fasciitis-in-infants-a-systematic-review
#19
Monika Wojtera, Horace Cheng, Kyle Fiorini, Kevin Coughlin, Michelle Barton, Julie Strychowsky
BACKGROUND: There is no consensus regarding approaches to infantile group B streptococcal (GBS) head and neck cellulitis and necrotizing fasciitis. We present a case of GBS necrotizing cellulitis and summarizes the literature regarding the presentation and management of infantile head and neck GBS cellulitis and necrotizing fasciitis. METHODS: The literature was searched using PubMed, Web of Science, EMBASE, and Medline (inception to April 2017) by two independent review authors...
February 7, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29417246/necrotizing-soft-tissue-infections-at-a-tertiary-referral-hospital-in-rwanda-epidemiology-and-risk-factors-for-mortality
#20
Christophe Mpirimbanyi, Jennifer Rickard, Charles Furaha, Faustin Ntirenganya
BACKGROUND: Necrotizing soft tissue infections (NSTI) are emergency surgical conditions with severe physiologic and metabolic derangement. These infections are associated with increased rates of mortality and morbidity worldwide, particularly in developing countries if not diagnosed and treated early. METHODS: This prospective, observational cohort study includes all patients aged 12 and above who presented at Department of Surgery, University Teaching Hospital of Kigali from April 2016 to January 2017 with NSTI...
February 7, 2018: World Journal of Surgery
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