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Necrotizing soft tissue infection

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https://www.readbyqxmd.com/read/28614442/skin-and-soft-tissue-infections-in-the-intensive-care-unit-a-retrospective-study-in-a-tertiary-care-center
#1
Luís Filipe Malheiro, Rita Magano, Alcina Ferreira, António Sarmento, Lurdes Santos
Objective: To identify factors that may influence outcomes in patients with severe skin and soft tissue infections in the intensive care unit. Methods: A retrospective observational study was conducted in a cohort of 1,123 critically ill patients admitted to an intensive care unit with a primary or secondary diagnosis of severe skin and soft tissues infection between January 2006 and December 2014. Results: Thirty patients were included, 20 (66...
June 12, 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28611889/evaluating-the-laboratory-risk-indicator-to-differentiate-cellulitis-from-necrotizing-fasciitis-in-the-emergency-department
#2
Michael M Neeki, Fanglong Dong, Christine Au, Jake Toy, Nima Khoshab, Carol Lee, Eugene Kwong, Ho Wang Yuen, Jonathan Lee, Arbi Ayvazian, Pamela Lux, Rodney Borger
INTRODUCTION: Necrotizing fasciitis (NF) is an uncommon but rapidly progressive infection that results in gross morbidity and mortality if not treated in its early stages. The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score is used to distinguish NF from other soft tissue infections such as cellulitis or abscess. This study analyzed the ability of the LRINEC score to accurately rule out NF in patients who were confirmed to have cellulitis, as well as the capability to differentiate cellulitis from NF...
June 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28600919/group-a-streptococci-infection-a-systematic-clinical-review-exemplified-by-cases-from-an-obstetric-department
#3
REVIEW
Line Winther Gustafson, Jan Blaakær, Rikke Bek Helmig
Group A streptococci infection has re-emerged since the 1980s and onward, despite the awareness of the etiology and the use of penicillin. It now accounts for more than 75,000 deaths worldwide every year. Postpartum women have a 20-fold increased incidence of group A streptococci disease compared to non-pregnant women. This review focuses on the epidemiology, pathophysiology, clinical presentation, prevention and treatment of group A streptococcal infection in pregnancy. SEARCH STRATEGY: We searched the following electronic databases from 1980-March 2016: PubMed-Medline, Embase, SveMed+, Bibliotek...
June 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28591027/necrotizing-fasciitis-a-catastrophic-complication-following-routine-tibia-fracture-surgery-a-case-report-and-literature-review
#4
Shuai Shang, Ruipeng Zhang, Zhiyong Hou
RATIONALE: Necrotizing fasciitis (NF) is defined as a rare, life-threatening, rapidly spreading soft tissue infection resulting from a polymicrobial origin, with a predominance of anaerobic organisms that presents with necrosis of the muscle, fascia, and surrounding soft tissue. PATIENT CONCERNS AND DIAGNOSES: A 64-year-old male who sustained tibia fracture caused by falling from a height underwent a tibia surgery with minimally invasive plate osteosynthesis technique in another institution...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28586594/risk-factors-for-necrotizing-fasciitis-and-its-outcome-at-a-tertiary-care-centre
#5
Yogendra Gupta, Manisha Chhetry, Kamal Raj Pathak, Ranjib Kumar Jha, Nischal Ghimire, Bibhuti Nath Mishra, Navin Kumar Karn, Ganesh Kumar Singh, Jatindra Nath Bhagabati
OBJECTIVE: Necrotizing fasciitis (NF) is a serious and potentially fatal condition where there is rapid progression of inflammation of skin, subcutaneous tissue, and superficial fascia and can be mono-microbial or poly-microbial. The disease is rapidly progressive in nature and if not promptly treated leads to significant morbidity or even mortality. This study was designed to explore the various risk factors commonly present and study the outcome of the disease. METHODS: This was a cross sectional study done in tertiary centre over period of one year from April 2014 to March 2015...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28583554/enterobacter-cloacae-related-necrotizing-fasciitis-after-peritoneal-dialysis-in-delayed-graft-function-a-case-report
#6
Y-M Choe, K-M Park, Y S Jeon, S G Cho, K C Hong, W Y Shin, J H Song
INTRODUCTION: Necrotizing fasciitis is an uncommon soft-tissue infection that involves the superficial fascia, subcutaneous fat, and deep fascia. Herein, we report the first case of Enterobacter cloacae-related necrotizing fasciitis after peritoneal dialysis in delayed graft function. CASE: A 58-year-old man, who was a hepatitis B-viral carrier and had atrial fibrillation, received cadaveric renal transplantation with peritoneal dialysis and encountered delayed graft function...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28566776/infected-nonunion-of-tibia
#7
Milind Madhav Chaudhary
Infected nonunions of tibia pose many challenges to the treating surgeon and the patient. Challenges include recalcitrant infection, complex deformities, sclerotic bone ends, large bone gaps, shortening, and joint stiffness. They are easy to diagnose and difficult to treat. The ASAMI classification helps decide treatment. The nonunion severity score proposed by Calori measures many parameters to give a prognosis. The infection severity score uses simple clinical signs to grade severity of infection. This determines number of surgeries and allows choice of hardware, either external or internal for definitive treatment...
May 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28566618/underlying-mechanisms-and-therapeutic-strategies-for-bisphosphonate-related-osteonecrosis-of-the-jaw-bronj
#8
Yasuo Endo, Hiroyuki Kumamoto, Masanori Nakamura, Shunji Sugawara, Teruko Takano-Yamamoto, Keiichi Sasaki, Tetsu Takahashi
Bisphosphonates (BPs), with a non-hydrolysable P-C-P structure, are cytotoxic analogues of pyrophosphate, bind strongly to bone, are taken into osteoclasts during bone-resorption and exhibit long-acting anti-bone-resorptive effects. Among the BPs, nitrogen-containing BPs (N-BPs) have far stronger anti-bone-resorptive effects than non-N-BPs. In addition to their pyrogenic and digestive-organ-injuring side effects, BP-related osteonecrosis of jaws (BRONJ), mostly caused by N-BPs, has been a serious concern since 2003...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28550986/acute-deep-infections-of-the-upper-extremity-the-utility-of-obtaining-atypical-cultures-in-the-presence-of%C3%A2-purulence
#9
Nikolas H Kazmers, George W Fryhofer, Daniel Gittings, David J Bozentka, David R Steinberg, Benjamin L Gray
PURPOSE: In the setting of acute deep upper extremity infections, evidence is lacking to guide the decision whether to send atypical cultures (fungal and acid-fast-bacillus [AFB]) during surgical debridement, especially in the presence of purulent fluid that is commonly observed with typical bacterial infections. Our purpose was to determine the frequency of positive atypical cultures and the frequency with which they alter treatment, and identify factors associated with positive atypical cultures...
May 25, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28541874/pasteurella-multocida-ecthyma-complicated-by-necrotizing-fasciitis
#10
Nima Milani-Nejad, Kelly Tyler, Carmine A Grieco, Benjamin H Kaffenberger
Necrotizing fasciitis is a serious infection of the skin and soft tissues. Pasteurella multocida is rarely reported to cause necrotizing fasciitis and is associated with high mortality. We describe a female patient with a past medical history of diabetes mellitus and myeloproliferative disorder presenting with bullae and erythema of the right forearm secondary to P. multocida infection after possible cat bite. Despite adequate antibiotic coverage she developed necrotizing fasciitis diagnosed clinically and on diagnostic imaging...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28538644/validation-of-a-clinical-trial-composite-endpoint-for-patients-with-necrotizing-soft-tissue-infections
#11
Eileen M Bulger, Addison May, Wayne Dankner, Greg Maislin, Bryce Robinson, Anat Shirvan
OBJECTIVE: Our objective was to develop and validate a composite endpoint for patients with necrotizing soft tissue infections (NSTI) that incorporates: local tissue injury, systemic organ dysfunction, and mortality. METHODS: The Necrotizing Infection Clinical Composite Endpoint (NICCE) was defined as follows:(i) Alive at day 28 (ii) ≤3 debridements prior to day 14 (iii) No amputation beyond first debridement (iv) Modified SOFA score (mSOFA) at day 14 ≤1. To be considered a success, all individual criteria must be met...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28484782/necrotizing-fasciitis-treatment-concepts-and-clinical-results
#12
M Leiblein, I Marzi, A L Sander, J H Barker, F Ebert, J Frank
BACKGROUND: Necrotizing fasciitis is a life-threatening soft tissue infection characterized by a rapid spreading infection of the subcutaneous tissue and in particular the fascia. The management of infected tissues requires a rapid diagnosis, immediate aggressive surgical management and an extended debridement. In some cases early amputations of the affected tissues and maximum intensive care treatment, in case of sepsis, are required. Due to a rising number of cases we aimed to evaluate our patients in a retrospective review...
May 8, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28480101/cervical-necrotizing-fasciitis-a-potentially-fatal-disease-with-varied-etiology
#13
T O Abdurrazaq, A A Ibikunle, R O Braimah
Necrotizing fasciitis was recognized centuries ago by physicians. It is a rapidly progressive and potentially fatal soft-tissue infection that is typified by soft-tissue necrosis, especially affecting the subcutaneous tissues and fascia. Cervico-facial necrotizing fasciitis is said to be uncommon, but when it occurs, it is often of odontogenic origin and has severe consequences if not promptly treated. Possible underlying systemic diseases and the source of infection should be addressed and treated appropriately...
July 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28474117/therapeutic-targets-in-necrotizing-soft-tissue-infections
#14
EDITORIAL
Nicolas de Prost, Jeffrey Lipman, Olivier Mimoz
No abstract text is available yet for this article.
May 4, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28470020/rapid-emergence-of-a-new-clone-impacts-the-population-at-risk-and-increases-the-incidence-of-type-emm89-group-a-streptococcus-invasive-disease
#15
Sarah Teatero, Brenda L Coleman, Stephen B Beres, Randall J Olsen, Christopher Kandel, Olivia Reynolds, Taryn B T Athey, James M Musser, Allison McGeer, Nahuel Fittipaldi
BACKGROUND: Invasive group A Streptococcus (iGAS) disease caused by type emm89 strains has been increasing worldwide, driven by the emergence of an epidemic clonal variant (clade 3 emm89). The clinical characteristics of patients with emm89 iGAS disease, and in particular with clade 3 emm89 iGAS disease, are poorly described. METHODS: We used population-based iGAS surveillance data collected in metropolitan Toronto, Ontario, Canada during the period 2000-2014. We sequenced the genomes of 105 emm89 isolates representing all emm89 iGAS disease cases in the area during the period and 138 temporally matched emm89 iGAS isolates collected elsewhere in Ontario...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28462035/whole-genome-sequencing-of-group-a-streptococcus-development-and-evaluation-of-an-automated-pipeline-for-emmgene-typing
#16
Georgia Kapatai, Juliana Coelho, Steven Platt, Victoria J Chalker
Streptococcus pyogenes group A Streptococcus (GAS) is the most common cause of bacterial throat infections, and can cause mild to severe skin and soft tissue infections, including impetigo, erysipelas, necrotizing fasciitis, as well as systemic and fatal infections including septicaemia and meningitis. Estimated annual incidence for invasive group A streptococcal infection (iGAS) in industrialised countries is approximately three per 100,000 per year. Typing is currently used in England and Wales to monitor bacterial strains of S...
2017: PeerJ
https://www.readbyqxmd.com/read/28452064/mortality-of-necrotising-fasciitis-relative-influence-of-individual-and-hospital-level-factors-a-nationwide-multi-level-study-france-2007-2012
#17
E Audureau, C Hua, N de Prost Nicolas, F Hemery, J W Decousser, R Bosc, R Lepeule, O Chosidow, E Sbidian
BACKGROUND: Necrotising soft-tissue infections (NSTI) are rare, life-threatening conditions. OBJECTIVES: We aimed to assess whether admitting hospital characteristics were associated with NSTI mortality. METHODS: We studied the French nationwide hospital discharge database (retrospective national cohort). All patients admitted in 2007-2012 with an ICD-10 code of necrotising fasciitis were eligible. We extracted data on the patients (age, sex, ICU admission, co-morbidities) and hospitals (public vs private proprietary; for public hospitals, teaching, yes/no; and number of NSTI admissions, ≥3 NSTI cases/year, yes/no)...
April 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28450145/are-anaerobes-a-major-underappreciated-cause-of-necrotizing-infections
#18
Hannah Zhao-Fleming, Sharmila Dissanaike, Kendra Rumbaugh
Necrotizing soft tissue infections (NSTIs) are the most severe and rapidly progressing class of skin and soft tissue infections (SSTIs). They are a surgical emergency and are associated with high mortality and morbidity. While NSTIs remain relatively rare, their incidence is steadily rising. Earlier diagnosis and more focused antibiotic treatments can potentially improve patient outcome, but both of these solutions require a more accurate understanding of the microbial component of these infections. While molecular detection methods, namely 16S sequencing, have not been traditionally used to identify the causative microorganisms in NSTIs, they are becoming more commonplace for other types of SSTIs, especially for chronic wound infections...
June 2017: Anaerobe
https://www.readbyqxmd.com/read/28410938/preservation-of-devitalized-bone-in-necrotic-digits-following-crush-injury-with-free-tissue-transfer
#19
Fei Song, Yongwei Pan, Zhe Zhao, Jiuzheng Deng, Changjiao Sun
Traditional management of necrotic digits has been to allow demarcation between viable and nonviable tissues to occur, and thus to indicate the level of amputation required. In this case report, the phalangeal length of the necrotic thumb was maintained in 2 patients who had sustained crush injury. After nonviable soft tissues were debrided, the devitalized bones were covered with soft tissue flaps. All wounds healed without infection. Both cosmetic and functional results of the reconstructed thumbs were satisfactory...
April 12, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28398176/septic-shock-due-to-nsti-caused-by-actinomyces-turicensis-the-role-of-clinical-pharmacology-case-report-and-review-of-the-literature
#20
Milo Gatti, Laura Elisa Gasparini, Chiara Maria Grimaldi, Daniela Abbati, Stefano Clemente, Paolo Riccardo Brioschi, Roberto Fumagalli, Francesco Scaglione
Critical septic patients affected by necrotizing soft tissue infections (NSTI) require an early, aggressive and multidisciplinary treatment. Pharmacokinetic alterations in antibiotic therapy are peculiar in these infections. Clinical pharmacology represents a first step in this setting. We report a case of septic shock due to NSTI in which clinical pharmacology is taken into account.
April 11, 2017: Journal of Chemotherapy
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