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G Niero, S Currò, A Costa, M Penasa, M Cassandro, C Boselli, G Giangolini, M De Marchi
Free radicals are reactive and unstable waste scrap molecules produced by cells, responsible of damages and alteration on DNA, proteins, and fat. The daily intake of antioxidant compounds, acting against free radicals and their detrimental effects, is essential for human health. Milk contains several compounds with antioxidant activity, and the sum of their reducing potential blocking free radicals development is defined as total antioxidant activity (TAA). This novel trait has been described in literature both in individual and bulk cow milk, but there are no reports from other dairy species...
March 14, 2018: Journal of Dairy Science
Paloma Herbello-Hermelo, Juan Pablo Lamas, Marta Lores, Raquel Domínguez-González, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro
An in vitro dialyzability approach has been undertaken to elucidate the bioavailable fraction of the total polyphenols (TPs) of edible nuts and seeds. The TP contents in samples and in dialyzates were assessed by the Folin-Ciocalteu spectrophotometric method. Antioxidant activity was determined in selected samples, using a modified method against Trolox®. TPs and antioxidant activity in nuts/seeds were determined after applying a pressurized liquid extraction sample pre-treatment. High dialyzability ratios were assessed in most nuts/seeds (TP dialyzability percentages within the 25-91% range)...
July 15, 2018: Food Chemistry
Xingrong Peng, Xia Wang, Long Chen, Han Yang, Lei Li, Shuangyang Lu, Lin Zhou, Minghua Qiu
Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pairs of racemates, (±)-cochlearins A-E, G (1-5, 7), and three new analogues, cochlearins F, H and I (6, 8, 9). Their structures were elucidated by extensive 1D, 2D NMR spectroscopic data and MS analyses...
March 11, 2018: Fitoterapia
Muhammad Luqman Nordin, Arifah Abdul Kadir, Zainul Amiruddin Zakaria, Rasedee Abdullah, Muhammad Nazrul Hakim Abdullah
BACKGROUND: Ardisia crispa Thunb. D.C is used mostly in some parts of the Asian region by traditional practitioners to treat certain diseases associated with oxidative stress and inflammation including cancer and rheumatism. In Malaysia, it is popularly known as 'Mata Ayam' and local traditional practitioners believed that the root of the plant is therapeutically beneficial. METHODS: The cytotoxic effect of hydromethanolic extract of A. crispa and its solvents partitions (ethyl acetate and aqueous extracts) against breast cancer cells were evaluated by using MTT assay...
March 12, 2018: BMC Complementary and Alternative Medicine
Sirin Uysal, Sulunay Parlar, Ayse H Tarikogullari, Fadime Aydin Kose, Vildan Alptuzun, Zeynep Soyer
A series of N-substituted-5-chloro-2(3H)-benzoxazolone derivatives were synthesized and evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) inhibitory, and antioxidant activities. The structures of the title compounds were confirmed by spectral and elemental analyses. The cholinesterase (ChE) inhibitory activity studies were carried out using Ellman's colorimetric method. The free radical scavenging activity was also determined by in vitro ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)) assay...
March 12, 2018: Archiv der Pharmazie
Maria F Quintero-Soto, Ana G Saracho-Peña, Jeanett Chavez-Ontiveros, Jose A Garzon-Tiznado, Karen V Pineda-Hidalgo, Francisco Delgado-Vargas, Jose A Lopez-Valenzuela
Chickpea (Cicer arietinum L.) genotypes, nine kabuli from Mexico and 9 desi from other countries, were investigated for their phenolic profiles and antioxidant activity (AA). Phenolics in methanol extracts (ME) were analyzed by ultra-performance liquid chromatography coupled to diode array detection and mass spectrometry (UPLC-DAD-MS), whereas the AA was measured as Trolox equivalents (TE) by ABTS, DPPH and FRAP methods. Twenty phenolic compounds were identified in the ME and their levels showed a great variability among the chickpea genotypes...
March 7, 2018: Plant Foods for Human Nutrition
Sevcan Erşan, Özlem Güçlü Üstündağ, Reinhold Carle, Ralf M Schweiggert
Pistachio hulls, important by-products of pistachio processing, were extracted using an environmentally friendly process with subcritical water (SCW) at a pressure of 6.9 MPa in the range of 110 and 190 °C, and a flow rate of 4 ml/min. Detailed HPLC-DAD-ESI/MSn analyses allowed the identification of 49 phenolic compounds in the SCW extracts. Total gallotannin yields up to 33 g/kg were reached at 150-170 °C, where gallic acid (22.2 g/kg) and penta-O-galloyl-β-d-glucose (9.77 g/kg) levels were 13...
July 1, 2018: Food Chemistry
F Ayca Ozdemir Olgun, Ayşem Üzer, Birsen Demirata Ozturk, Reşat Apak
Antioxidant activity (AOA) assays using nanotechnology are recently developed utilizing nanoparticles of transition metal oxides, especially nanoceria that can switch between trivalent and tetravalent oxidation states of cerium. Cerium oxide nanoparticles (CeO-NPs) may act as both an oxidant and an antioxidant, depending on the preparation method and particle size. A novel colorimetric sensor for AOA assay is proposed with the use of poly(acrylic acid) sodium salt (PAANa)-coated CeO-NPs. PAANa-coated CeO-NPs oxidized tetramethyl benzidine (TMB), a peroxidase substrate, in a slightly acidic solution at pH 4...
May 15, 2018: Talanta
Suvimol Somwongin, Panuwan Chantawannakul, Wantida Chaiyana
Pharmacological effects of bee venom has been reported, however, it has been restricted to the bee venom collected from European honey bee (Apis mellifera). The aim of the present study was to compare the antioxidant activities and irritation properties of venoms collected from four different Apis species in Thailand, which includes Apis cerena (Asian cavity nesting honeybee), Apis florea (dwarf honeybee), Apis dorsata (giant honeybee), and A. mellifera. Melittin content of each bee venom extracts was investigated by using high-performance liquid chromatography...
February 27, 2018: Toxicon: Official Journal of the International Society on Toxinology
Dominika Mániková, Zuzana Šestáková, Jana Rendeková, Danuša Vlasáková, Patrícia Lukáčová, Edgars Paegle, Pavel Arsenyan, Miroslav Chovanec
Resveratrol is a natural (poly)phenol primarily found in plants protecting them against pathogens, as well as harmful effects of physical and chemical agents. In higher eukaryotic cells and organisms, this compound displays a remarkable range of biological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-aging, cardio- and neuro-protective properties. Here, biological activities of synthetic selenium-containing derivatives of resveratrol-benzo[ b ]selenophenes-have been studied in lower eukaryotes Saccharomyces cerevisiae ...
February 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Zahra Bahadoran, Mattias Carlström, Asghar Ghasemi, Parvin Mirmiran, Fereidoun Azizi, Farzad Hadaegh
Background: Considering the lack of data on the association between habitual dietary intakes of nitrate (NO3 - ) and nitrite (NO2 - ) and cardiovascular events, we assessed possible effects of dietary NO3 - and NO2 - , in the context of total antioxidant capacity (TAC) of the diet, with the risk of cardiovascular (CVD) outcomes. Methods: Adult men and women without CVD ( n  = 2369) were recruited from the Tehran Lipid and Glucose Study and were followed for a mean of 6...
2018: Nutrition & Metabolism
Tânia Melo, Sara S Marques, Isabel Ferreira, Maria Teresa Cruz, Pedro Domingues, Marcela A Segundo, Maria Rosário Marques Domingues
Nitro-fatty acids (NO2 -FA) have been widely studied with regard to their identification, structural characterization, and biological actions. NO2 -FA could also be present endogenously esterified to phospholipids (PL), and NO2 -PL were already detected in cardiac mitochondria from diabetic rats and cardiomyoblasts subjected to starvation. However, the biological actions of NO2 -PL have been overlooked. In this study, we evaluate the antioxidant and anti-inflammatory potential of the nitrated 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) formed in vitro by incubation with NO2 BF4 , in a well-recognized mimetic model of nitroxidative stress...
January 2018: Lipids
XiaoXuan Guo, XiaoHong Sha, Ebeydulla Rahman, Yong Wang, BaoPing Ji, Wei Wu, Feng Zhou
Millet bran, the by-product of millet processing industry, contains an abundance of phytochemicals, especially polyphenols. The main objective of this study was brewing antioxidant wine from millet bran, as well as the nutritional evaluation. The total polyphenol content of wine samples was determined by Folin-Ciocalteu colorimetric method, and the antioxidant capacity was evaluated by DPPH radical-scavenging capacity, Trolox equivalent antioxidant capacity (TEAC), and ferric reducing antioxidant power (FRAP)...
March 2018: Journal of Food Science and Technology
Eva Pigna, Alessandra Renzini, Emanuela Greco, Elena Simonazzi, Stefania Fulle, Rosa Mancinelli, Viviana Moresi, Sergio Adamo
BACKGROUND: Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy. Histone deacetylase 4 (HDAC4) mediates skeletal muscle response to denervation, suggesting the use of HDAC inhibitors as a therapeutic approach to neurogenic muscle atrophy. However, the effects of HDAC4 inhibition in skeletal muscle in response to long-term denervation have not been described yet...
February 24, 2018: Skeletal Muscle
C M Batista, A V F Alves, L A Queiroz, B S Lima, R N P Filho, A A S Araújo, R L C de Albuquerque Júnior, J C Cardoso
The negative effects triggered by ultraviolet radiation, such as premature aging and carcinogenesis, have motivated several studies on photoprotection. Recent strategies for photoprotection have included the incorporation of natural antioxidant and anti-inflammatory compounds, such as flavonoids, into sunscreens and the oral administration of natural antioxidant extracts. Brazilian Red propolis extract contains isoflavonoids with antioxidant and anti-inflammatory activities. Here, we investigate the photoprotective effects of orally- or topically-administered formulations containing hydroalcoholic extract of red propolis (HERP) in a rodent model...
January 31, 2018: Journal of Photochemistry and Photobiology. B, Biology
Shang-Shu Ding, Ping Sun, Zhou Zhang, Xiang Liu, Hong Tian, Yong-Wei Huo, Li-Rong Wang, Yan Han, Jun-Ping Xing
Background: The worsening of semen quality, due to the application of Wi-Fi, can be ameliorated by Vitamin E. This study aimed to demonstrate whether a moderate dose of trolox, a new Vitamin E, inhibits oxidative damage on sperms in vitro after exposure to Wi-Fi radiation. Methods: Each of the twenty qualified semen, gathered from June to October 2014 in eugenics clinic, was separated into four aliquots, including sham, Wi-Fi-exposed, Wi-Fi plus 5 mmol/L trolox, and Wi-Fi plus 10 mmol/L trolox groups...
February 20, 2018: Chinese Medical Journal
Yuki Uchihara, Takayuki Kidokoro, Kenji Tago, Tadahiko Mashino, Hiroomi Tamura, Megumi Funakoshi-Tago
Crizotinib is an inhibitor of anaplastic lymphoma kinase (ALK) and is of significant therapeutic benefit to patients with non-small cell lung cancer (NSCLC) harboring the EML4-ALK fusion gene. In the present study, we demonstrated that α-tocopherol, a major component of vitamin E, attenuated the effects of crizotinib independently of its anti-oxidant properties. α-Tocopherol significantly inhibited crizotinib-induced apoptosis in cells transformed by EML4-ALK. It also effectively attenuated the crizotinib-induced inhibition of EML4-ALK and its downstream molecules, STAT3 and ERK, and suppressed the inhibitory effects of crizotinib on EML4-ALK-mediated transformation in the focus formation assay...
February 11, 2018: European Journal of Pharmacology
Sajjad Lalegani, Hassan Ahmadi Gavlighi, Mohammad Hossein Azizi, Roghayeh Amini Sarteshnizi
Phenolic compounds as agro-industrial by-products have been associated with health benefits since they exhibit high antioxidant activity and anti-diabetic properties. In this study, polyphenol-rich extract from pistachio green hull (PGH) was evaluated for antioxidant activity and its ability to inhibit α-amylase and α-glucosidase activity in vitro. The effect of PGH extract powder on in vitro starch digestibility was also evaluated. The results showed that PGH had stronger antioxidant activity than Trolox...
March 2018: Food Research International
Roberto Biondi, Stefano Brancorsini, Giulia Poli, Maria Giulia Egidi, Enrico Capodicasa, Livio Bottiglieri, Sandro Gerli, Eleonora Brillo, Gian Carlo Di Renzo, Dragos Cretoiu, Romeo Micu, Nicolae Suciu
Hydroxyl radical (.OH) is highly reactive, and therefore very short-lived. Finding new means to accurately detect .OH, and testing the ability of known .OH scavengers to neutralize them in human biological fluids would leverage our ability to more effectively counter oxidative (.OH) stress-mediated damage in human diseases. To achieve this, we pursued the evaluation of secondary products resulting from .OH attack, using a detection system based on Fenton reaction-mediated D-phenylalanine (D-Phe) hydroxylation...
May 1, 2018: Talanta
Allisson Benatti Justino, Natália Carnevalli Miranda, Rodrigo Rodrigues Franco, Mário Machado Martins, Neide Maria da Silva, Foued Salmen Espindola
Annona muricata leaves are used in traditional medicine to manage diabetes mellitus and its complications. The aim of this study was to evaluate the potential in vitro antidiabetic properties of Annona muricata leaf by identifying its main phytochemical constituents and characterizing the phenolic-enriched fractions for their in vitro antioxidant capacity and inhibitory activities against glycoside and lipid hydrolases, advanced glycation end-product formation and lipid peroxidation. Ethanol extract of A. muricata leaf was subjected to a liquid-liquid partitioning and its fractions were used in enzymatic assays to evaluate their inhibitory potential against α-amylase, α-glucosidase and lipase, as well as their antioxidant (DPPH, ORAC, FRAP and Fe2+-ascorbate-induced lipid peroxidation assays) and anti-glycation (BSA-fructose, BSA-methylglyoxal and arginine-methylglyoxal models) capacities...
February 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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