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https://www.readbyqxmd.com/read/29350786/multiple-biological-defects-caused-by-calycosin-7-o-%C3%AE-d-glucoside-in-the-nematode-caenorhabditis-elegans-are-associated-with-the-activation-of-oxidative-damage
#1
Jianqin Zhang, Xiaoli Xue, Yang Yang, Wen Ma, Yan Han, Xuemei Qin
Calycosin-7-O-β-d-glucoside (CG) is an important active isoflavone compound in Radix Astragali that has many bioactivities. However, the toxicological effects and related toxicological mechanism of CG have been rarely documented. The purpose of the present study was to evaluate the toxicity effects of CG on the model organism Caenorhabditis elegans. Some characteristics of the nematode, including lifespan, movement behavior and reproductive capacity, were used to detect the toxic effects of CG on C. elegans...
January 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29347842/in-vitro-antioxidant-potential-and-in-vivo-effects-of-schinus-terebinthifolia-raddi-leaf-extract-in-diabetic-rats-and-determination-of-chemical-composition-by-hplc-esi-ms-ms
#2
Camila Cristina Iwanaga, Lilian Dos Anjos Oliveira Ferreira, Karine Zanoli Bernuci, Carla Maria Mariano Fernandez, Fabiana Brusco Lorenzetti, Camila Caviquioli Sehaber, Flávia Cristina Vieira Frez, Sara Santos Bernardes, Gean Pier Panizzon, Giani Andrea Linde, Maria do Carmo Vieira, Jacqueline Nelisis Zanoni, Diógenes Aparício Garcia Cortez
The present study investigated the in vitro and in vivo antioxidant potential and phytochemical composition of Schinus terebinthifolia, which is widely used in folk medicine for various therapeutic purposes. The in vitro analyses indicated that the hydroethanolic extract (HE) had 312.50 ± 0.50 mg GAE/g of total phenols. It also presented anti-DPPH• and anti-ABTS•+ activity, reduced phosphomolybden and metal ions and blocked the bleaching of β-carotene. The HE at concentrations of 3.0 and 2.0 μg/mL had TRAP values of 2...
January 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29345918/antiinflammatory-and-antioxidant-activities-from-the-basolateral-fraction-of-caco-2-cells-exposed-to-a-rosmarinic-acid-enriched-extract
#3
Marisol Villalva, Laura Jaime, Estela Aguado, Juan Antonio Nieto, Guillermo J Reglero, Susana Santoyo
The potential use of Origanum majorana L. as a source of bioavailable phenolic compounds, specifically rosmarinic acid (RA), has been evaluated. Phenolic bioavailability was tested using an in vitro digestion process followed by a Caco-2 cellular model of intestinal absorption. The HPLC-PAD-MS/MS analysis showed the main components in the extract were 6-hydroxyluteolin-7-O-glucoside and rosmarinic acid, followed by luteolin-O-glucoside. After digestion process, the amount of total phenolic compounds (TPC) only decreased slightly, although a remarkable reduction in RA (near 50%) was detected...
January 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29344877/a-bioluminescent-test-system-reveals-valuable-antioxidant-properties-of-lactobacillus-strains-from-human-microbiota
#4
Maria Marsova, Serikbay Abilev, Elena Poluektova, Valeriy Danilenko
Oxidative stress cause serious damages in human organism resulting in multiple diseases. Antioxidant therapy includes diet, the use of chemical agents or commensal bacteria such as lactobacilli. This study aims to evaluate the antioxidant (AO) activity of cell-free culture supernatants of lactobacilli, isolated from different parts of the human body. A test system based on Escherichia coli MG1655 strains carrying plasmids encoding luminescent biosensors pSoxS-lux and pKatG-lux inducible by superoxide anion and hydrogen peroxide, respectively, was used to analyze cell-free culture supernatants of lactobacilli...
January 17, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29333393/effect-of-monascus-fermented-soybean-extracts-on-antioxidant-and-skin-aging-related-enzymes-inhibitory-activities
#5
Yoo-Jeong Jin, Young-Hee Pyo
We investigated the in vitro inhibitory activity against skin aging-related enzymes and antioxidant activity of Monascus-fermented soybean extracts (MFSEs) obtained by using different solvents. The highest Trolox equivalent (TE) antioxidant capacity (3.13±0.06 mM TE/g) and oxygen radical absorbance capacity (2.79±0.09 mM TE/g) of MFSEs were evaluated for the methanol and 80% ethanol extracts, respectively. The antioxidant capacities increased with increasing concentration (0.5~50 mg/mL). In addition, the methanol and 80% ethanol extracts showed an effective inhibition against tyrosinase, hyaluronidase, and elastase compared with those of acetone and hot water extracts (P<0...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29329851/chemical-characterization-of-myrciaria-floribunda-h-west-ex-willd-fruit
#6
Luciana Mouta de Oliveira, Alexandre Porte, Ronoel Luiz de Oliveira Godoy, Marcelo da Costa Souza, Sidney Pacheco, Manuela Cristina Pessanha de Araujo Santiago, Ana Cristina Miranda Senna Gouvêa, Luzimar da Silva de Mattos do Nascimento, Renata Galhardo Borguini
M. floribunda fruit was studied to characterize its chemical composition. The chemical composition, bioactive compounds, antioxidant activity and volatiles of the fruit were determined. The chemical composition was determined according to AOAC and AOCS, the bioactive compounds by HPLC, the volatiles by GCMS and the antioxidant activity by ABTS+ and DPPH methods. The chemical composition of the freeze-dried fruit was 1.89 g·100 g-1, 2.43 g·100 g-1, 4.78 g·100 g-1 and 90.89 g·100 g-1 of ashes, lipids, proteins and total carbohydrates on a dry base, respectively...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329836/fermented-apulian-table-olives-effect-of-selected-microbial-starters-on-polyphenols-composition-antioxidant-activities-and-bioaccessibility
#7
Isabella D'Antuono, Angelica Bruno, Vito Linsalata, Fiorenza Minervini, Antonella Garbetta, Maria Tufariello, Giovanni Mita, Antonio F Logrieco, Gianluca Bleve, Angela Cardinali
The effects of fermentation by autochthonous microbial starters on phenolics composition of Apulian table olives, Bella di Cerignola (BDC), Termite di Bitetto (TDB) and Cellina di Nardò (CEL) were studied, highlighting also the cultivars influence. In BDC with starter, polyphenols amount doubled compared with commercial sample, while in TDB and CEL, phenolics remain almost unchanged. The main phenolics were hydroxytyrosol, tyrosol, verbascoside and luteolin, followed by hydroxytyrosol-acetate detected in BDC and cyanidine-3-glucoside and quercetin in CEL...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29321995/anticonvulsant-effect-of-ethanolic-extract-of-cyperus-articulatus-l-leaves-on-pentylenetetrazol-induced-seizure-in-mice
#8
Oscar Herrera-Calderon, Rocio Santiváñez-Acosta, Bertha Pari-Olarte, Edwin Enciso-Roca, Vicente Martin Campos Montes, Jorge Luis Arroyo Acevedo
Cyperus articulatus (CA) rhizomes have demonstrated different properties on nervous system. However, the leaves still have not studied to treat epilepsy. The aim of this study was to determine the effect of CA ethanolic extract on pentylenetetrazol (PTZ) induced seizures in mice as well as measuring its antioxidant activity in vivo and in vitro. Mice were divided into five groups: (1) control (PTZ 80 mg/kg; i.p.), (2) PTZ-Diazepam (1 mg/kg; i.p.), (3-5) PTZ-CA 50, PTZ-CA 150 and PTZ-CA 300 (50, 150 and 300 mg/kg of CA extract, 30 min prior to each PTZ injection)...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29316691/a-comparative-study-on-phytochemical-profiles-and-biological-activities-of-sclerocarya-birrea-a-rich-hochst-leaf-and-bark-extracts
#9
Daniela Russo, Rocchina Miglionico, Monica Carmosino, Faustino Bisaccia, Paula B Andrade, Patrícia Valentão, Luigi Milella, Maria Francesca Armentano
Sclerocarya birrea (A.Rich.) Hochst (Anacardiaceae) is a savannah tree that has long been used in sub-Saharan Africa as a medicinal remedy for numerous ailments. The purpose of this study was to increase the scientific knowledge about this plant by evaluating the total content of polyphenols, flavonoids, and tannins in the methanol extracts of the leaves and bark (MLE and MBE, respectively), as well as the in vitro antioxidant activity and biological activities of these extracts. Reported results show that MLE is rich in flavonoids (132...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29316619/radical-scavenging-and-anti-inflammatory-activities-of-representative-anthocyanin-groupings-from-pigment-rich-fruits-and-vegetables
#10
Federica Blando, Nadia Calabriso, Helge Berland, Gabriele Maiorano, Carmela Gerardi, Maria Annunziata Carluccio, Øyvind M Andersen
Anthocyanins, the naturally occurring pigments responsible for most red to blue colours of flowers, fruits and vegetables, have also attracted interest because of their potential health effects. With the aim of contributing to major insights into their structure-activity relationship (SAR), we have evaluated the radical scavenging and biological activities of selected purified anthocyanin samples (PASs) from various anthocyanin-rich plant materials: two fruits (mahaleb cherry and blackcurrant) and two vegetables (black carrot and "Sun Black" tomato), differing in anthocyanin content (ranging from 4...
January 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29310631/acute-effect-of-clitoria-ternatea-flower-beverage-on-glycemic-response-and-antioxidant-capacity-in-healthy-subjects-a-randomized-crossover-trial
#11
Charoonsri Chusak, Thavaree Thilavech, Christiani Jeyakumar Henry, Sirichai Adisakwattana
BACKGROUND: Clitoria ternatea L., a natural food-colorant containing anthocyanin, demonstrated antioxidant and antihyperglycemic activity. The aim of this study was to determine the effects of Clitoria ternatea flower extract (CTE) on postprandial plasma glycemia response and antioxidant status in healthy men. METHODS: In a randomized, crossover study, 15 healthy men (ages 22.53 ± 0.30 years; with body mass index of 21.57 ± 0.54 kg/m2) consumed five beverages: (1) 50 g sucrose in 400 mL water; (2) 1 g CTE in 400 mL of water; (3) 2 g CTE in 400 mL of water; (4) 50 g sucrose and 1 g CTE in 400 mL of water; and (5) 50 g sucrose and 2 g CTE in 400 mL of water...
January 8, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29290751/optimization-and-validation-of-two-high-throughput-methods-indicating-antiradical-activity
#12
Graciela Granados-Guzmán, Ricardo Salazar-Aranda, Marsela Garza-Tapia, Rocío Castro-Ríos, Noemí Waksman de Torres
Background: The search for new natural or synthetic products with antioxidant activity is commonly based on methods that involve reduction of either 2,2-diphenyl-1-picrylhydrazyl (DPPH) or 2-2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). However, the reported values of the effective concentrations are highly variable, even in controls. Herein, we optimize and validate both meth-ods of determining antiradical activity. Methods: Optimization was carried out using both a fractionated factorial design and a basic sequential simplex method, by monitoring the reduction percentage...
December 2017: Current Analytical Chemistry
https://www.readbyqxmd.com/read/29287452/changes-in-the-gaba-and-polyphenols-contents-of-foxtail-millet-on-germination-and-their-relationship-with-in-vitro-antioxidant-activity
#13
Seema Sharma, Dharmesh C Saxena, Charanjit S Riar
Germination along with ultrasonic assisted extraction induced a significant beneficial effect on the characteristics of polyphenolic components profile, GABA contents and in vitro antioxidant capacity of the foxtail millet flour extracts. The total antioxidant activity (29.0-45.23 mgAAE/g) and reducing power (0.53-0.76 µg/ml) increase during germination were due to quantitative increase in phthalicacid; hex-3yl-ester; hexadecanoicacid methylester etc. whereas, increase in DPPH (48.32-59.62%) and hydrogen peroxide scavenging activities (35...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29287419/bioaccessibility-of-phenolic-compounds-following-in-vitro-large-intestine-fermentation-of-nuts-for-human-consumption
#14
Gabriele Rocchetti, Giulia Chiodelli, Gianluca Giuberti, Luigi Lucini
A bioaccessibility study of polyphenols after in vitro simulated large intestine fermentation was carried out on edible nuts. Raw nuts were also analysed for total phenolic content and antioxidant potential, considering both bound and free phenolics. The highest phenolic content was found in walnuts, followed by pistachios extracts (596.9 and 410.1 mg gallic acid equivalents 100 g-1, respectively). Consistently, the total antioxidant capacity was highest in walnuts (3689.7 μM trolox equivalents 100 g-1) followed by peanuts and pistachios (3169...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29287388/effects-of-salinity-on-bacterial-communities-maillard-reactions-isoflavone-composition-antioxidation-and-antiproliferation-in-korean-fermented-soybean-paste-doenjang
#15
Mi Jeong Kim, Han Sub Kwak, Sang Sook Kim
The purpose of this study was to investigate bacterial communities and health-benefit-related parameters in doenjang prepared with various brine concentrations (8, 12, 16, and 20%). Phenolic, flavonoid, melanoidin and isoflavone contents, antioxidation, and antiproliferation of doenjang (AD8, AD12, AD16, and AD20) aged for 3 months were compared with those of initial doenjang (ID8, ID12, ID16, and ID20). The ID8 and AD8 doenjang, made with 8% brine, contained higher phenolics, melanoidins, and isoflavones than those with high salinity...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29287256/a-simple-and-efficient-synthesis-of-benzimidazoles-containing-piperazine-or-morpholine-skeleton-at-c-6-position-as-glucosidase-inhibitors-with-antioxidant-activity
#16
Musa Özil, Cansu Parlak, Nimet Baltaş
A novel 2-(aryl)-6-morpholin-4-yl(or 4-methylpiperazin-1-yl)-1H-benzimidazole derivatives were designed and expeditiously synthesized starting from 5-morpholin-4-yl(or 4-methylpiperazin-1-yl)-2-nitroaniline with various aldehydes which were preliminarily screened for in vitro antioxidant activities and glucosidase inhibitors. The benzimidazoles were effectively synthesized by a rapid 'onepot' nitro reductive cyclization reaction using sodium hydrosulfite as a reagent. All reactions were conducted using both the microwave and conventional methods to compare yields and reaction times...
December 16, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29281656/bark-anatomy-chemical-composition-and-ethanol-water-extract-composition-of-anadenanthera-peregrina-and-anadenanthera-colubrina
#17
Graciene S Mota, Caroline J Sartori, Isabel Miranda, Teresa Quilhó, Fábio Akira Mori, Helena Pereira
The bark of Anadenanthera peregrina (L.) Speg and Anadenanthera colubrina (Vell.) Brenan were characterized in relation to anatomical and chemical features. The barks were similar and included a thin conducting phloem, a largely dilated and sclerified non-conducting phloem, and a rhyridome with periderms with thin phellem interspersed by cortical tissues. Only small differences between species were observed that cannot be used alone for taxonomic purposes. The summative chemical composition of A. peregrina and A...
2017: PloS One
https://www.readbyqxmd.com/read/29278023/effect-of-%C3%AE-tocopherol-megadoses-on-hematologic-parameters-and-antioxidant-capacity-of-rats-in-an-ultraendurance-probe
#18
V J Clemente-Suárez, J Mielgo-Ayuso, J L Quiles, A Varela-Lopez, P Aranda
This study was aimed to analyze the effect of two different megadoses of α-tocopherol (vit E) in the antioxidant activity and red and white blood series of Wistar rats after a 180-min ultraendurance probe. Three groups of 10 rats were analyzed; VEAG: acute administration of a megadoses of 5,000 IU/kg of vit E the day before the probe; VECG: chronic administration of 1,000 IU/kg/day of vit E for 6 days before the probe; CG: placebo administration. VEAG presented white cells, red blood cells, hematocrit, hemoglobin values significantly higher than CG and VECG (p < 0...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29249156/antiobesity-efficacy-of-quercetin-rich-supplement-on-diet-induced-obese-rats-effects-on-body-composition-serum-lipid-profile-and-gene-expression
#19
Yu-Wen Ting, Wei-Tang Chang, Duen-Kai Shiau, Pei-Hsuan Chou, Mei-Fang Wu, Chin-Lin Hsu
The anti-obesity effects of quercetin-rich supplement (QRS), which contain quercetin, lycopene, taurine, and litchi flower extract, on a high-fat diet (HFD)-induced obese rats were investigated. The rats that consume HFD with QRS (185 mg/kg rat) have significantly modulated the final body weights [490±11 (HFD)→441±11 (HFD+QRS) g], total body fat [112.9±4.5 (HFD)→86.6±5.7 (HFD+QRS) g], liver weights [14.8±0.4 (HFD)→12.6±0.4 (HFD+QRS) g/rat], and the serum TG [102.5±7.3 (HFD)→90.7±6.5 (HFD+QRS) mg/dL] to a level that resembled the regular diet-consumed rats (p<0...
December 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29247565/oocyte-oxidative-dna-damage-may-be-involved-in-minimal-mild-endometriosis-related-infertility
#20
Michele Gomes Da Broi, Alceu Afonso Jordão-Jr, Rui Alberto Ferriani, Paula Andrea Navarro
Early endometriosis is associated with infertility, and oxidative stress may play a role in the pathogenesis of disease-related infertility. This prospective case-control study aimed to compare the presence of oxidative stress markers in the follicular microenvironment and systemic circulation of infertile women with minimal/mild endometriosis (EI/II) versus individuals undergoing controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI). Seventy-one blood samples (27 from infertile women with EI/II and 44 controls with tubal and/or male infertility factor) and 51 follicular fluid samples (19 EI/II and 32 controls) were obtained on the day of oocyte retrieval...
December 16, 2017: Molecular Reproduction and Development
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