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https://www.readbyqxmd.com/read/28725872/antioxidant-and-lipoxygenase-activities-of-polyphenol-extracts-from-oat-brans-treated-with-polysaccharide-degrading-enzymes
#1
Nisita Ratnasari, Mallory Walters, Apollinaire Tsopmo
This study used polysaccharide degrading enzymes and protein precipitation to extract polyphenols from oats and to determine their bioactivity. Duplicate oat brans were treated with viscozyme (Vis), cellulase (Cel) or no enzyme (control, CTL) then, proteins were removed in one set (Vis1, Cel1, CTL1) and not in the other (Vis2, Cel2, CTL2). HPLC analyses showed that for cellulase treated brans, precipitation of proteins increased phenolic acids and avenanthramides by 14%. Meanwhile, a decreased of 67% and 20% respectively was found for viscozyme and control brans...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28725621/chemical-composition-acute-toxicity-antioxidant-and-anti-inflammatory-activities-of-moroccan-tetraclinis-articulata-l
#2
Meryem El Jemli, Rabie Kamal, Ilias Marmouzi, Zouhra Doukkali, El Houcine Bouidida, Driss Touati, Rachid Nejjari, Lahcen El Guessabi, Yahia Cherrah, Katim Alaoui
Hydro-distilled essential oil (EO) from the leaves of the western Mediterranean and Moroccan endemic plant Tetraclinis articulata was analyzed by GC/MS and examined for its acute toxicity on mice, in order to establish the safe doses. Furthermore, the anti-Inflammatory activity was evaluated based on carrageenan and trauma induced rats paw edema and the antioxidant potential has been investigated using different methods including DPPH radical-scavenging assay, Trolox equivalent antioxidant capacity (TEAC) and Ferric-reducing antioxidant power assay (FRAP)...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28720929/antioxidant-characteristics-of-extracts-of-hibiscus-sabdariffa-calyces-encapsulated-with-mesquite-gum
#3
C E Ochoa-Velasco, C Salazar-González, S Cid-Ortega, J A Guerrero-Beltrán
This study compared the stability of extracts of H. sabdariffa calyces microencapsulated with different concentrations of mesquite gum during storage. Dry Roselle calyces were mixed with 50:50 (v/v) ethanol:water solution to obtain 18°Bx concentrate. This Roselle extract concentrate was mixed with purified mesquite gum (100:1-100:5 v/w). The Roselle extract concentrate-gum (RECG) was spray dried at inlet and outlet temperatures of 180 ± 2 and 104 ± 2.3 °C, respectively, at an air flow rate of 38 m(3)/h...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28718789/flavonoid-and-antioxidant-capacity-of-propolis-prediction-using-near-infrared-spectroscopy
#4
Eddy Betances-Salcedo, Isabel Revilla, Ana M Vivar-Quintana, M Inmaculada González-Martín
The use of propolis as a dietary supplement or as an ingredient in different food products is increasing, due to its antioxidant and bactericidal properties. These nutritional properties directly depend on its phenolic composition. For this reason, this study analysed the total contents of flavones and flavonols, flavanones and dihydroflavonols, and the antioxidant capacity by using the methods of ABTS and linoleic acid/β-carotene in 99 samples of propolis from Spain and Chile. A rapid method was developed for quantifying these parameters in raw propolis using near infrared (NIR) spectroscopy with a remote reflectance fibre-optic probe applied directly to the ground-up sample...
July 18, 2017: Sensors
https://www.readbyqxmd.com/read/28713820/antioxidant-properties-of-natchez-and-triple-crown-blackberries-using-korean-traditional-winemaking-techniques
#5
Youri Joh, Niels Maness, William McGlynn
This research evaluated blackberries grown in Oklahoma and wines produced using a modified traditional Korean technique employing relatively oxygen-permeable earthenware fermentation vessels. The fermentation variables were temperature (21.6°C versus 26.6°C) and yeast inoculation versus wild fermentation. Wild fermented wines had higher total phenolic concentration than yeast fermented wines. Overall, wines had a relatively high concentration of anthocyanin (85-320 mg L(-1) malvidin-3-monoglucoside) and antioxidant capacity (9776-37845 µmol Trolox equivalent g(-1))...
2017: International journal of food science
https://www.readbyqxmd.com/read/28710022/taxifolin-reduces-the-cholesterol-oxidation-product-induced-neuronal-apoptosis-by-suppressing-the-akt-and-nf-%C3%AE%C2%BAb-activation-mediated-cell-death
#6
Arum Kim, Yoon Jeong Nam, Chung Soo Lee
The taxifolin effect on the cholesterol oxidation product-induced neuronal apoptosis was investigated using differentiated PC12 cells and human neuroblastoma SH-SY5Y cells. 7-ketocholesterol induced phosphorylation of Akt, and increase in the levels of cytosolic and nuclear NF-κB p65, cytosolic NF-κB p50 and cytosolic phosphorylated-IκB-α in PC12 cells. The cholesterol oxidation products also induced a decrease in the levels of Bid and Bcl-2, increase in the levels of p53 and Bax, loss of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases (-8, -9 and -3), production of reactive oxygen species, depletion of GSH and cell death in both cell lines...
July 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28708113/dietary-phytochemicals-promote-health-by-enhancing-antioxidant-defence-in-a-pig-model
#7
Sophie N B Selby-Pham, Jeremy J Cottrell, Frank R Dunshea, Ken Ng, Louise E Bennett, Kate S Howell
Phytochemical-rich diets are protective against chronic diseases and mediate their protective effect by regulation of oxidative stress (OS). However, it is proposed that under some circumstances, phytochemicals can promote production of reactive oxygen species (ROS) in vitro, which might drive OS-mediated signalling. Here, we investigated the effects of administering single doses of extracts of red cabbage and grape skin to pigs. Blood samples taken at baseline and 30 min intervals for 4 hours following intake were analyzed by measures of antioxidant status in plasma, including Trolox equivalent antioxidant capacity (TEAC) and glutathione peroxidase (GPx) activity...
July 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28698913/antibacterial-and-antioxidant-constituents-of-extracts-of-endophytic-fungi-isolated-from-ocimum-basilicum-var-thyrsiflora-leaves
#8
Piyamas Atiphasaworn, Sakon Monggoot, Eleni Gentekaki, Siraprapa Brooks, Patcharee Pripdeevech
Fourteen fungal endophytes were isolated from the Ocimum basilicum var. thyrsiflora leaves collected from Northern Thailand. Eight genera were identified including Aspergillus, Ascochyta, Nigrospora, Blastomyces, Colletotrichum, Exidia, Clitopilus, and Nomuraea. The antibacterial activity of crude extracts from all endophytic fungi was tested against nine human bacterial pathogens: Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Bacillus cereus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Vibrio cholerae, and Vibrio parahaemolyticus...
July 12, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28696542/-pro-renin-receptor-activation-increases-profibrotic-markers-and-fibroblast-like-phenotype-through-mapk-dependent-ros-formation-in-mouse-renal-collecting-duct-cells
#9
Alexis A Gonzalez, Leonardo Zamora, Cristian Reyes-Martinez, Nicolas Salinas-Parra, Nicole Roldan, Catherina A Cuevas, Stefanny Figueroa, Alex Gonzalez-Vergara, Minolfa C Prieto
Recent studies suggested that activation of the PRR upregulates profibrotic markers through reactive oxygen species (ROS) formation; however, the exact mechanisms have not been investigated in CD cells. We hypothesized that activation of the PRR increases the expression of profibrotic markers through MAPK-dependent ROS formation in CD cells. Mouse renal CD cell line (M-1) was treated with recombinant prorenin plus ROS or MAPK inhibitors and PRR-shRNA to evaluate their effect on the expression of profibrotic markers...
July 11, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28694749/variability-of-antioxidant-and-biological-activities-of-rhus-tripartitum-related-to-phenolic-compounds
#10
Hanène Ben Miled, Mariem Saada, Ines Jallali, Zaineb Ben Barka, Mounira Tlili, Hichem Alimi, Mohsen Sakly, Khémais Ben Rhouma, Manef Abderrabba, Hafedh Abdelmelek, Olfa Tebourbi, Riadh Ksouri
Rhus species are known in traditional medicine for their therapeutic virtue and their extracts showed numerous important properties including antimalarial, antimicrobial, antiviral, and hypoglycemic and anticonvulsant activities. Rhus tripartitum (Ucria) is a medicinal plant widely used in Tunisia folk medicine against chronic diarrhea and gastric ulcer. This study was designed to examine in vitro and ex vivo antioxidant, anti-inflammatory and anticancer activities of four extracts of Rhus tripartitum root cortex with increasing solvent polarity (hexane, dichloromethane, methanol and water)...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28687235/synthesis-and-evaluation-of-26-amino-acid-methyl-ester-substituted-sarsasapogenin-derivatives-as-neuroprotective-agents-for-alzheimer-s-disease
#11
Ze-Dan Wang, Guo-Dong Yao, Wei Wang, Wen-Bao Wang, Shao-Jie Wang, Shao-Jiang Song
Sarsasapogenin, extracted from Anemarrhena asphodeloides Bunge., has been reported to protect neurons from H2O2-induced damage. In the current study, four series of 26-amino acid methyl ester substituted sarsasapogenin derivatives (5a-5e, 5f-5j, 6a-6e and 7a-7e) were synthesized and tested for neuroprotective activity by evaluating their neuroprotective ratio against SH-SHY5Y cell lines. Studies showed that most of the target compounds displayed better neuroprotective effects than that of sarsasapogenin. Structure-activity relationship analysis suggested that 3-methoxy derivatives (5f-5j) were more potent than other series and the phenylalanine methyl ester moiety at C-26 was important for exhibiting apparent neuroprotective activity...
July 4, 2017: Steroids
https://www.readbyqxmd.com/read/28683396/enrichment-of-antioxidants-in-black-garlic-juice-using-macroporous-resins-and-their-protective-effects-on-oxidation-damaged-human-erythrocytes
#12
Ying Zou, Mouming Zhao, Kun Yang, Lianzhu Lin, Yong Wang
The black garlic juice is popular for its nutritive value. Enrichment of antioxidants is needed to make black garlic extract an effective functional ingredient. Five macroporous resins were evaluated for their capacity in adsorbing antioxidants in black garlic juice. XAD-16 resin was chosen for further study due to its high adsorption and desorption ratios. Pseudo-second-order kinetics (qe=625μmol Trolox equiv/g dry resin, k2=0.0001463) and Freundlich isotherm models (ΔH=-10.1547kJ/mol) were suitable for describing the whole exothermic and physical adsorption processes of the antioxidants from black garlic juice on XAD-16 resin...
June 22, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28672789/evaluating-modern-techniques-for-the-extraction-and-characterisation-of-sunflower-hellianthus-annus-l-seeds-phenolics
#13
Panagiotis Zoumpoulakis, Vassilia J Sinanoglou, Eleni Siapi, George Heropoulos, Charalampos Proestos
Recently there is a great interest in using high energy techniques (HET) which involve microwave or ultrasound-assisted extraction (MAE and UAE) for isolation of natural bioactive compounds from plant foods. Such bioactive compounds are phenolics which were determined from sunflower (Helianthus annuus L.) kernels and hulls (defatted) utilising two different high energy extraction techniques, ultrasound and microwave assisted solvent extraction. All samples were characterised by ultra-high-performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MS)...
June 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28667876/a-novel-structural-class-of-coumarin-chalcone-fibrates-as-ppar%C3%AE-%C3%AE-agonists-with-potent-antioxidant-activities-design-synthesis-biological-evaluation-and-molecular-docking-studies
#14
Handong Niu, Wenbao Wang, Jinyan Li, Yu Lei, Yong Zhao, Weixu Yang, Chaoyue Zhao, Bin Lin, Shaojiang Song, Shaojie Wang
A series of structurally interesting coumarin-chalcone fibrates were synthesized and evaluated for their PPARα/γ agonist activities and antioxidant activities. Among these compounds, compounds 5a, 5d, and 7a were identified as potent PPARα and γ dual agonists, and their PPARα agonist activities were found to be more potent than that of Fenofibrate. Furthermore, the results of antioxidant investigations revealed that compounds 5d and 6a-6d had greater potency than Trolox with IC50 values ranging from 9...
June 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28665488/chemical-composition-and-antioxidant-activity-of-the-volatile-fraction-extracted-from-air-dried-fruits-of-tunisian-eryngium-maritimum-l-ecotypes
#15
Houda Ben Lajnef, Federico Ferioli, Federica Pasini, Joanna Politowicz, Abdelhamid Khaldi, L Filippo D'Antuono, Maria Fiorenza Caboni, Nizar Nasri
BACKGROUND: Eryngium maritimum L., also known as "sea holly", is a typical dune plant species belonging to the Apiaceae family and commonly used in Tunisia for therapeutic purposes in folk medicine. In the present study, the chemical composition and antioxidant activity of the volatile fraction extracted from air-dried fruits of five Tunisian E. maritimum ecotypes were determined. RESULTS: The total volatile amount ranged from 0.31 to 0.93% (w d.w.(-1) ). Sixty-six volatile components were identified by means of GC-MS and accounted for 77...
June 30, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28662656/effect-of-vitamin-e-on-oxidative-stress-level-in-blood-synovial-fluid-and-synovial-tissue-in-severe-knee-osteoarthritis-a-randomized-controlled-study
#16
Saran Tantavisut, Aree Tanavalee, Sittisak Honsawek, Tanyawan Suantawee, Srihatach Ngarmukos, Sirichai Adisakwatana, John J Callaghan
BACKGROUND: This study was performed to evaluate the antioxidative and anti-inflammatory effects of vitamin E on oxidative stress in the plasma, synovial fluid, and synovial tissue of patients with knee osteoarthritis. METHODS: Seventy-two patients with late-stage knee osteoarthritis scheduled for total knee arthroplasty were randomized to take oral placebo (Group A) or 400 IU of vitamin E (Group B) once a day for 2 months before undergoing surgery. The blood levels of endpoints indicating oxidative stress or antioxidant capacity, Knee Society Score (KSS), Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC), and adverse effects were compared before and after the intervention between the two groups...
June 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28652076/radical-trapping-and-preventive-antioxidant-effects-of-2-hydroxymelatonin-and-4-hydroxymelatonin-contributions-to-the-melatonin-protection-against-oxidative-stress
#17
Adriana Pérez-González, Annia Galano, J Raúl Alvarez-Idaboy, Dun Xian Tan, Russel J Reiter
BACKGROUND: Melatonin is well known for its antioxidant capacity, which has been attributed to the combined protective effects of the parent molecule and its metabolites. However, the potential role of 2-hydroxymelatonin (2OHM) and 4-hydroxymelatonin (4OHM) in such protection has not been previously investigated. METHODS: The calculations were performed using the Density Functional Theory, with the M05-2X and M05 functionals, the 6-311+G(d,p) basis set and the solvation model based on density (SMD)...
June 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28645884/investigation-of-the-effects-of-lycium-barbarum-polysaccharides-against-cadmium-induced-damage-in-testis
#18
Maria Vittoria Varoni, Sergio Domenico Gadau, Valeria Pasciu, Elena Baralla, Elisa Serra, Domenico Palomba, Maria Piera Demontis
This study describes the effects of Lycium barbarum polysaccharides (LBP) on testicular damage induced by cadmium (Cd). Adult male rats were i.p. injected with CdCl2 (4mg/Kg, once) with or without LBP pretreatment (300mg/Kg orally, once a day, for 30days). Testis weight, morphological/histological structure and oxidative stress parameters were evaluated. Several adverse effects were observed after CdCl2 injection, with a significant decrease in body/testis weight ratio (P<0.05), gross morphological changes with hyperemia of the parenchyma, increased volume and alteration in the structure of the seminiferous tubules...
June 20, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28643512/quantitatively-intrinsic-biomimetic-catalytic-activity-of-nanocerias-as-radical-scavengers-and-their-ability-against-h2o2-and-doxorubicin-induced-oxidative-stress
#19
Zhimin Tian, Xuhui Li, Yuanyuan Ma, Tao Chen, Dehui Xu, Bingchuan Wang, Yongquan Qu, Yuan Gao
Artificial enzymes as radical scavengers show great potentials in treatments of various diseases induced by oxidative stress. Herein, the quantitative analysis indicates that the intrinsic activity of nanocerias for the degradation of radicals is determined by the concentration of surface defects as well as their morphological features. The surface Ce(3+) fraction of the CeO2 nanozymes with a similar morphology can be used as a descriptor to index their catalytic activity as radical scavengers. Defect-abundant porous nanorods of ceria (PN-CeO2) with a large surface area (141 m(2)/g) and high surface Ce(3+) fraction (32...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28642814/lc-qtof-ms-analysis-and-activity-profiles-of-popular-antioxidant-dietary-supplements-in-terms-of-quality-control
#20
Elwira Sieniawska, Tomasz Baj, Rafal Sawicki, Aleksandra Wanat, Krzysztof Kamil Wojtanowski, Grazyna Ginalska, Grazyna Zgorka, Jolanta Szymanska
The dietary supplements with claimed antioxidant activity constitute a substantial part of the dietary supplement market. In this study, we performed the LC-QTOF-MS analysis and investigated the activity profiles of popular antioxidant dietary supplements from different chemical groups in terms of quality control. The commonly used antioxidant tests and statistical analysis revealed that substantial part of the results was comparable if 1 g sample was considered, but while comparing single and daily doses, significant differences in antioxidant values were noticed in all assays...
2017: Oxidative Medicine and Cellular Longevity
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