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https://www.readbyqxmd.com/read/28643512/quantitatively-intrinsic-biomimetic-catalytic-activity-of-nanocerias-as-radical-scavengers-and-their-ability-against-h2o2-and-doxorubicin-induced-oxidative-stress
#1
Zhimin Tian, Xuhui Li, Yuanyuan Ma, Tao Chen, Dehui Xu, Bingchuan Wang, Yuan Gao, Yongquan Qu
Artificial enzymes as radical scavengers show great potentials in treatments on various diseases induced by oxidative stress. Herein, the quantitative analysis indicates the intrinsic activity of nanocerias for degradation of radicals is de-termined by the concentration of surface defects as well as their morphological features. The surface Ce3+ fraction of the CeO2 nanozymes with the similar morphology can be used as a descriptor to index their catalytic activity as radical scavengers. Defect-abundant porous nanorods of ceria (PN-CeO2) with a large surface area (141 m2/g) and high surface Ce3+ fraction (32...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28642814/lc-qtof-ms-analysis-and-activity-profiles-of-popular-antioxidant-dietary-supplements-in-terms-of-quality-control
#2
Elwira Sieniawska, Tomasz Baj, Rafal Sawicki, Aleksandra Wanat, Krzysztof Kamil Wojtanowski, Grazyna Ginalska, Grazyna Zgorka, Jolanta Szymanska
The dietary supplements with claimed antioxidant activity constitute a substantial part of the dietary supplement market. In this study, we performed the LC-QTOF-MS analysis and investigated the activity profiles of popular antioxidant dietary supplements from different chemical groups in terms of quality control. The commonly used antioxidant tests and statistical analysis revealed that substantial part of the results was comparable if 1 g sample was considered, but while comparing single and daily doses, significant differences in antioxidant values were noticed in all assays...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28629341/protective-effects-of-cynara-scolymus-leaves-extract-on-metabolic-disorders-and-oxidative-stress-in-alloxan-diabetic-rats
#3
Maryem Ben Salem, Rihab Ben Abdallah Kolsi, Raouia Dhouibi, Kamilia Ksouda, Slim Charfi, Mahdi Yaich, Serria Hammami, Zouheir Sahnoun, Khaled Mounir Zeghal, Kamel Jamoussi, Hanen Affes
BACKGROUND: Diabetes mellitus (DM) is associated with hyperglycemia, inflammatory disorders and abnormal lipid profiles, currently the extracts from leaves of cynara scolymus has been discovered to treat metabolic disorders and has been stated by multitudinous scientists according to a good source of polyphenols compounds. The present study aimed to evaluate the protective effect of the ethanol leaves extract of C. scolymus in alloxan induced stress oxidant, hepatic-kidney dysfunction and histological changes in liver, kidney and pancreas of different experimental groups of rats...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28628845/serum-antioxidant-capacity-and-oxidative-damage-in-clinical-and-subclinical-canine-ehrlichiosis
#4
Camila Peres Rubio, Zeki Yilmaz, Silvia Martínez-Subiela, Meric Kocaturk, Josefa Hernández-Ruiz, Ebru Yalcin, Asta Tvarijonaviciute, Damián Escribano, Jose Joaquín Ceron
The objective of this study was to evaluate and compare the antioxidant response and the products of oxidative damage analysed by various assays in clinical and subclinical canine monocytic ehrlichiosis (CME). For this purpose, four assays to measure the total serum antioxidant capacity (TAC), such as the cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of plasma (FRAP), trolox equivalent antioxidant capacity (TEAC) using acidic medium (TEACA), and the TEAC using the horseradish peroxidase (TEACH) were used...
June 12, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28622381/cell-free-dna-release-by-mouse-placental-explants
#5
Mark Phillippe, Sharareh Adeli
Although suggested that "fetal" cell-free DNA (cfDNA) is derived from trophoblast cells, the exact origin is unclear. The studies in this report sought to demonstrate that placental tissue releases cfDNA in parallel with cell death, that the size range of cfDNA is similar to that found in maternal plasma, and that the cfDNA fragments are able to stimulate a proinflammatory cytokine response. Placentas were harvested from near term pregnant CD-1 mice and cultured in DMEM/Ham's F12/FBS media in 8% or 21% O2. After centrifugation to remove cells and cellular debris, the cfDNA was extracted from the media and quantified by DNA spectrophotometry...
2017: PloS One
https://www.readbyqxmd.com/read/28614371/chemical-characterization-and-extractives-composition-of-heartwood-and-sapwood-from-quercus-faginea
#6
Isabel Miranda, Vicelina Sousa, Joana Ferreira, Helena Pereira
Heartwood and sapwood of Quercus faginea were evaluated in relation to summative chemical composition and non-polar and polar extracts composition, including an assessment of antioxidant properties (DPPH and FRAP). Twenty trees from two sites in Portugal were analysed. Heartwood had approximately two times more solvent extractible compounds than sapwood (on average 19.0% and 9.5%). The lipophilic extractible compounds were below 1%, and most of them were polar e.g. ethanol-soluble compounds corresponded to 65% of total extractives in heartwood and 43% in sapwood...
2017: PloS One
https://www.readbyqxmd.com/read/28613965/effect-of-saliva-collection-methods-and-oral-hygiene-on-salivary-biomarkers
#7
Allisson Benatti Justino, Renata Roland Teixeira, Leonardo Gomes Peixoto, Olga Lucia Bocanegra Jaramillo, Foued Salmen Espindola
The aim of this study was to evaluate the influence of unstimulated and stimulated saliva collection methods, as well as tooth brushing, on the secretion rate of salivary total protein, nitrite, total antioxidant capacity and alpha-amylase. Saliva of 14 healthy individuals were collected with stimulation using Salivette(®), Parafilm(®) and chewing gum and without stimulation from spit with and without fluid accumulation, before and after oral hygiene. Total protein, nitrite, total antioxidant capacity and alpha-amylase concentration (sAA) were evaluated...
June 14, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28604588/docosahexaenoic-acid-induces-expression-of-heme-oxygenase-1-and-nad-p-h-quinone-oxidoreductase-through-activation-of-nrf2-in-human-mammary-epithelial-cells
#8
Hye-Yoon Bang, Sin-Aye Park, Soma Saeidi, Hye-Kyung Na, Young-Joon Surh
Docosahexaenoic acid (DHA), an ω-3 fatty acid abundant in fish oils, has diverse health beneficial effects, such as anti-oxidative, anti-inflammatory, neuroprotective, and chemopreventive activities. In this study, we found that DHA induced expression of two representative antioxidant/cytoprotective enzymes, heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase (NQO1), in human mammary epithealial (MCF-10A) cells. DHA-induced upregulation of these enzymes was accompanied by enhanced translocation of the redox-sensitive transcription factor Nrf2 into the nucleus and its binding to antioxidant response element...
June 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28595495/lipid-based-nanoformulation-of-lycopene-improves-oral-delivery-formulation-optimization-ex-vivo-assessment-and-its-efficacy-against-breast-cancer
#9
Archu Singh, Yub Raj Neupane, Bibhu Prasad Panda, Kanchan Kohli
This study aims at developing an optimized Nanostructured Lipid Carrier (NLC) of Lycopene for efficient absorption following oral administration. The optimized formulation showed an average particle size of 121.9±3.66 nm, Poly dispersity index (PDI) 0.370±0.97 and zeta potential -29.0± 0.83 mV. Encapsulation Efficiency (% EE) and Drug Loading (% DL) was found to be 84.50% ± 4.38 and 9.54% ± 2.65 respectively. In vitro release studies demonstrated the burst release within 4-9 h followed by sustained release over 48 h...
June 9, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28587204/comparative-analysis-of-%C3%AE-oryzanol-%C3%AE-glucan-total-phenolic-content-and-antioxidant-activity-in-fermented-rice-bran-of-different-varieties
#10
Tae-Dong Jung, Gi-Hae Shin, Jae-Min Kim, Sun-Il Choi, Jin-Ha Lee, Sang Jong Lee, Seon Ju Park, Koan Sik Woo, Sea Kwan Oh, Ok-Hawn Lee
Rice bran, a by-product derived from processing rice, is a rich source of bioactive compounds. Recent studies have suggested that the fermentation can improve their biological activities. This study aimed to determined the level of γ-oryzanol, β-glucan and total phenol contents of fermented rice bran from 21 Korean varieties, as well as to evaluate their antioxidant activities. We also assessed the validation of the analytical method for determining γ-oryzanol content in fermented rice brans. Among the fermented rice brans, the Haedam rice bran contained the highest level of total phenol content (156...
June 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28578994/synthesis-molecular-docking-and-biological-activity-of-polyfluoroalkyl-dihydroazolo-5-1-c-1-2-4-triazines-as-selective-carboxylesterase-inhibitors
#11
Evgeny V Shchegol'kov, Galina F Makhaeva, Natalia P Boltneva, Sofya V Lushchekina, Olga G Serebryakova, Elena V Rudakova, Nadezhda V Kovaleva, Yanina V Burgart, Victor I Saloutin, Oleg N Chupakhin, Sergey O Bachurin, Rudy J Richardson
To search for effective and selective inhibitors of carboxylesterase (CaE), a series of 7-hydroxy-7-polyfluoroalkyl-4,7-dihydroazolo[5,1-c][1,2,4]triazines has been synthesized. Their inhibitory activity against acetylcholinesterase, butyrylcholinesterase, and CaE were investigated using the methods of enzyme kinetics and molecular docking. It was shown that the tested compounds are reversible selective CaE inhibitors of mixed type. Elongation of the polyfluoroalkyl substituent and the presence of an ester, preferably the ethoxycarbonyl group, enhance inhibitory activity toward CaE...
May 20, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28572932/comparison-of-phenolic-content-and-antioxidant-activities-of-millet-varieties-grown-in-different-locations-in-sri-lanka
#12
Disna Kumari, Terrence Madhujith, Anoma Chandrasekara
Soluble and bound phenolic compounds were extracted from different varieties of millet types namely, finger millet, foxtail, and proso millet cultivated at dry and intermediate climatic zones in Sri Lanka. The extracts were examined for their total phenolic content (TPC), total flavonoid content (TFC), and proanthocyanidin content (PC). The antioxidant activities were meassured by reducing power (RP), trolox equivalent antioxidant capacity (TEAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferrous ion chelating ability (FICA), and using a β carotene linoleate model system...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28567126/tacrine-trolox-and-tryptoline-as-lead-compounds-for-the-design-and-synthesis-of-multi-target-agents-for-alzheimer-s-disease-therapy
#13
Gerard A K Teponnou, Jacques Joubert, Sarel F Malan
The versatile biological activities of tacrine, trolox and β-carboline derivatives make them promising lead structures for the development of multifunctional Alzheimer's disease (AD) agents. Based on the topology of the active site of cholinesterases and other target proteins involved in the pathogenesis of AD, we have designed and synthesized tacrine-trolox and tacrine-tryptoline hybrids with various linker chain lengths. The hybrids containing the trolox moiety (8a-8d) showed moderate to high TcAChE inhibition (IC50: 17...
2017: Open Medicinal Chemistry Journal
https://www.readbyqxmd.com/read/28560092/comparison-in-antioxidant-and-antitumor-activities-of-pine-polyphenols-and-its-seven-biotransformation-extracts-by-fungi
#14
Hui Li, Zhenyu Wang
Microbial transformation can strengthen the antioxidant and antitumor activities of polyphenols. Polyphenols contents, antioxidant and antitumor activities of pine polyphenols and its biotransformation extracts by Aspergillus niger, Aspergillus oryzae, Aspergillus carbonarius, Aspergillus candidus, Trichodermas viride, Mucor wutungkiao and Rhizopus sp were studied. Significant differences were noted in antioxidant and antitumor activities. The highest antioxidant activities in Trolox equivalent antioxidant capacity (TEAC), DPPH radical scavenging activity, superoxide anion radical scavenging activity, hydroxyl radical scavenging activity, reducing power assay and antitumor activity against LoVo cells were biotransformation extract of Aspergillus carbonarius (BAC), biotransformation extract of Mucor wutungkiao (BMW), biotransformation extract of Aspergillus carbonarius (BAC), biotransformation extract of Aspergillus niger (BAN), biotransformation extract of Aspergillus oryzae (BAO) and BMW, respectively...
2017: PeerJ
https://www.readbyqxmd.com/read/28559739/polyphenols-from-wine-lees-as-a-novel-functional-bioactive-compound-in-the-protection-against-oxidative-stress-and-hyperlipidaemia
#15
Irena Landeka, Jurčević, Mirna Dora, Iva Guberović, Marija Petras, Suzana Rimac, Brnčić, Domagoj Đikić
The study examines the potential of wine industry by-product, the lees, as a rich mixture of natural polyphenols, and its physiological potential to reduce postprandial metabolic and oxidative stress caused by a cholesterol-rich diet in in vivo model. Chemical analysis of wine lees showed that their total solid content was 94.2%. Wine lees contained total phenols, total nonflavonoids and total flavonoids expressed in mg of gallic acid equivalents per 100 g of dry mass: 2316.6±37.9, 1332.5±51.1 and 984.1±28...
March 2017: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/28557380/lipid-and-phenolic-constituents-from-seeds-of-hypericum-perforatum-l-and-hypericum-tetrapterum-fr-and-their-antioxidant-activity
#16
Miriam Heinrich, Peter Lorenz, Rolf Daniels, Florian C Stintzing, Dietmar R Kammerer
Seeds of Hypericum perforatum and H. tetrapterum were extracted with dichloromethane and methanol and investigated by chromatographic and mass spectrometric methods. Both species yielded a fatty oil fraction amounting to 30.5% and 18.0% of the seed weight, respectively. Linoleic acid (C18:2n-6) was shown to be the predominant fatty acid constituent. Moreover, xanthone derivatives, i.e. tetrahydroxyxanthones (THX), xanthone-glycosides and xanthone-sulfonates, were assigned in methanolic extracts. For structure elucidation, one representative xanthone, namely 1,3,6,7-THX, was synthesized and analyzed via HPLC-DAD-MS(n) and GC-MS...
May 29, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28555014/in-vitro-antioxidant-activity-of-idebenone-derivative-loaded-solid-lipid-nanoparticles
#17
Lucia Montenegro, Maria N Modica, Loredana Salerno, Anna Maria Panico, Lucia Crascì, Giovanni Puglisi, Giuseppe Romeo
Idebenone (IDE) has been proposed for the treatment of neurodegenerative diseases involving mitochondria dysfunctions. Unfortunately, to date, IDE therapeutic treatments have not been as successful as expected. To improve IDE efficacy, in this work we describe a two-step approach: (1) synthesis of IDE ester derivatives by covalent linking IDE to other two antioxidants, trolox (IDETRL) and lipoic acid (IDELIP), to obtain a synergic effect; (2) loading of IDE, IDETRL, or IDELIP into solid lipid nanoparticles (SLN) to improve IDE and its esters' water solubility while increasing and prolonging their antioxidant activity...
May 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28554820/argininic-acid-alters-markers-of-cellular-oxidative-damage-in-vitro-protective-role-of-antioxidants
#18
Daniela Delwing-de Lima, Simone Sasso, Leticia Dalmedico, Débora Delwing-Dal Magro, Eduardo Manoel Pereira, Angela T S Wyse
We, herein, investigated the in vitro effects of argininic acid on thiobarbituric acid-reactive substances (TBA-RS), total sulfhydryl content and on the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the blood, kidney and liver of 60-day-old rats. We also verified the influence of the antioxidants (each at 1.0mM) trolox and ascorbic acid, as well as of N(G)-nitro-l-arginine methyl ester (L-NAME) at 1.0mM, a nitric oxide synthase inhibitor, on the effects elicited by argininic acid on the parameters tested...
May 26, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28551238/characterization-of-betalains-saponins-and-antioxidant-power-in-differently-colored-quinoa-chenopodium-quinoa-varieties
#19
Josefa Escribano, Juana Cabanes, Mercedes Jiménez-Atiénzar, Martha Ibañez-Tremolada, Luz Rayda Gómez-Pando, Francisco García-Carmona, Fernando Gandía-Herrero
Quinoa was the traditional grain crop used by the prehispanic civilizations in America. Grains are white, black, yellow, and red-violet and plants are cultivated in vast areas of Peru, Bolivia and Ecuador. The recent description of the betacyanin pigment betanin in red-violet varieties is here further analyzed detecting the presence of amaranthin not previously identified in quinoa grains. Yellow-orange grains are characterized for the first time and up to four different betaxanthins are found to be responsible for this coloration...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28539721/phytochemical-and-biological-evaluations-of-arum-hygrophilum-boiss-araceae
#20
Fatma U Afifi, Violet Kasabri, Simona Litescu, Ismail F Abaza, Khalid Tawaha
BACKGROUND: Arum hygrophilum is a traditional medicinal plant indigenous to Jordan. The present study explores its phytochemistry, antioxidative, antidiabesity, and antiproliferative potentialities. MATERIALS AND METHODS: Column chromatography and HPLC-MS analysis were used for its phytochemical evaluation. Using leaf crude water and ethanol extracts, the antioxidative capacities, their modulation of pancreatic β-cell proliferation, and insulin secretion as well as glucose diffusion and enzymatic bioassays were evaluated...
April 2017: Pharmacognosy Magazine
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