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https://www.readbyqxmd.com/read/27910787/nonvolatile-taste-components-and-antioxidant-properties-of-fruiting-body-and-mycelium-with-high-ergothioneine-content-from-the-culinary-medicinal-golden-oyster-mushroom-pleurotus-citrinopileatus-agaricomycetes
#1
Shin-Yi Lin, Shih-Chang Chien, Sheng-Yang Wang, Jeng-Leun Mau
Pleurotus citrinopileatus mycelium was prepared with high ergothioneine (Hi-Ergo) content and its proximate composition, nonvolatile taste components, and antioxidant properties were studied. The ergothioneine contents of fruiting bodies and Hi-Ergo and regular mycelia were 3.89, 14.57, and 0.37 mg/g dry weight, respectively. Hi-Ergo mycelium contained more dietary fiber, soluble polysaccharides, and ash but less carbohydrates, reducing sugar, fiber, and fat than regular mycelium. However, Hi-Ergo mycelium contained the smallest amounts of total sugars and polyols (47...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27904389/performance-of-different-natural-antioxidant-compounds%C3%A2-in-frying-oil
#2
Buket Aydenız, Emin Yilmaz
In this study, the natural green tea extract, purified lycopene, purified resveratrol and purified γ-oryzanol were added into peanut oil and their antioxidant performances were evaluated during frying. Moreover, the sensory properties of fried dough were evaluated to determine the consumption feasibility. All natural antioxidants led to significant increase in the stability of the oil samples. The ranges of measurements in the treatment groups were as follows: free acidity 0.1-2.9 g of oleic acid per 100 g of oil, conjugated dienes 0...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27897980/protective-effects-of-%C3%AE-tocopherol-%C3%AE-tocopherol-and-oleic-acid-three-compounds-of-olive-oils-and-no-effect-of-trolox-on-7-ketocholesterol-induced-mitochondrial-and-peroxisomal-dysfunction-in-microglial-bv-2-cells
#3
Meryam Debbabi, Thomas Nury, Amira Zarrouk, Nadia Mekahli, Maryem Bezine, Randa Sghaier, Stéphane Grégoire, Lucy Martine, Philippe Durand, Emmanuelle Camus, Anne Vejux, Aymen Jabrane, Lionel Bretillon, Michel Prost, Thibault Moreau, Sofien Ben Ammou, Mohamed Hammami, Gérard Lizard
Lipid peroxidation products, such as 7-ketocholesterol (7KC), may be increased in the body fluids and tissues of patients with neurodegenerative diseases and trigger microglial dysfunction involved in neurodegeneration. It is therefore important to identify synthetic and natural molecules able to impair the toxic effects of 7KC. We determined the impact of 7KC on murine microglial BV-2 cells, especially its ability to trigger mitochondrial and peroxisomal dysfunction, and evaluated the protective effects of α- and γ-tocopherol, Trolox, and oleic acid (OA)...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27896020/identification-of-phenolic-secondary-metabolites-from-schotia-brachypetala-sond-fabaceae-and-demonstration-of-their-antioxidant-activities-in-caenorhabditis-elegans
#4
Mansour Sobeh, Esraa ElHawary, Herbenya Peixoto, Rola M Labib, Heba Handoussa, Noha Swilam, Ahmed H El-Khatib, Farukh Sharapov, Tamer Mohamed, Sonja Krstin, Michael W Linscheid, Abdel Nasser Singab, Michael Wink, Nahla Ayoub
BACKGROUND: Schotia brachypetala Sond. (Fabaceae) is an endemic tree of Southern Africa whose phytochemistry and pharmacology were slightly studied. The present work aimed at profiling the major phenolics compounds present in the hydro-alcohol extract from S. brachypetala leaves (SBE) using LC/HRESI/MS/MS and NMR and prove their antioxidant capabilities using novel methods. METHODS: In vitro assays; DPPH, TEAC persulfate decolorizing kinetic and FRAP assays, and in vivo assays: Caenorhabditis elegans strains maintenance, Intracellular ROS in C...
2016: PeerJ
https://www.readbyqxmd.com/read/27895554/systemic-radical-scavenger-treatment-of-a-mouse-model-of-rett-syndrome-merits-and-limitations-of-the-vitamin-e-derivative-trolox
#5
Oliwia A Janc, Marc A Hüser, Katharina Dietrich, Belinda Kempkes, Christiane Menzfeld, Swen Hülsmann, Michael Müller
Rett syndrome (RTT) is a severe neurodevelopmental disorder typically arising from spontaneous mutations in the X-chromosomal methyl-CpG binding protein 2 (MECP2) gene. The almost exclusively female Rett patients show an apparently normal development during their first 6-18 months of life. Subsequently, cognitive- and motor-impairment, hand stereotypies, loss of learned skills, epilepsy and irregular breathing manifest. Early mitochondrial impairment and oxidative challenge are considered to facilitate disease progression...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27889456/synthesis-of-new-morpholine-connected-pyrazolidine-derivatives-and-their-antimicrobial-antioxidant-and-cytotoxic-activities
#6
Radhakrishnan Surendra Kumar, Meera Moydeen, Salem S Al-Deyab, Aseer Manilal, Akbar Idhayadhulla
A simple and convenient one-pot four-component synthesis of morpholine-connected pyrazolidine derivatives 2a-f and 4a-f was developed using direct metal-free catalysis, with the identities of the synthesized compounds confirmed by IR, NMR ((1)H and (13)C), mass spectrometry, and elemental analysis. The prepared compounds were inspected for antimicrobial, antioxidant, and cytotoxic activities. Antimicrobial and antifungal activities against five bacterial and four fungal pathogens, respectively, were investigated using the disc diffusion technique...
November 14, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27882602/the-resveratrol-derivatives-trans-3-5-dimethoxy-4-fluoro-4-hydroxystilbene-and-trans-2-4-5-trihydroxystilbene-decrease-oxidative-stress-and-prolong-lifespan-in-caenorhabditis-elegans
#7
Nadine Fischer, Christian Büchter, Karoline Koch, Sabrina Albert, René Csuk, Wim Wätjen
OBJECTIVES: Resveratrol (trans-3,4',5-trihydroxystilbene (1)) was previously shown to extend the lifespan of different model organisms. However, its pharmacological efficiency is controversially discussed. Therefore, the bioactivity of four newly synthesized stilbenes (trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene (3), trans-4'-hydroxy-3,4,5-trifluorostilbene (4), trans-2,5-dimethoxy-4'-hydroxystilbene (5), trans-2,4',5-trihydroxystilbene (6)) was compared to (1) and pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene (2)) in the established model organism Caenorhabditis elegans...
November 23, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27867271/wound-healing-activity-and-chemical-standardization-of-eugenia-pruniformis-cambess
#8
Ricardo Diego Duarte Galhardo de Albuquerque, Jamila Alessandra Perini, Daniel Escorsim Machado, Thaís Angeli-Gamba, Ricardo Dos Santos Esteves, Marcelo Guerra Santos, Adriana Passos Oliveira, Leandro Rocha
BACKGROUND: Eugenia pruniformis is an endemic species from Brazil. Eugenia genus has flavonoids as one of the remarkable chemical classes which are related to the improvement of the healing process. AIMS: To evaluate of wound healing activity of E. pruniformis leaves and to identify and quantify its main flavonoids compounds. MATERIALS AND METHODS: Wound excision model in rats was used to verify the hydroethanolic and ethyl acetate extracts potential...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27865495/assessment-of-multifunctional-activity-of-bioactive-peptides-derived-from-fermented-milk-by-specific-lactobacillus-plantarum-strains
#9
J E Aguilar-Toalá, L Santiago-López, C M Peres, C Peres, H S Garcia, B Vallejo-Cordoba, A F González-Córdova, A Hernández-Mendoza
Milk-derived bioactive peptides with a single activity (e.g., antioxidant, immunomodulatory, or antimicrobial) have been previously well documented; however, few studies describe multifunctional bioactive peptides, which may be preferred over single-activity peptides, as they can simultaneously trigger, modulate, or inhibit multiple physiological pathways. Hence, the aim of this study was to assess the anti-inflammatory, antihemolytic, antioxidant, antimutagenic, and antimicrobial activities of crude extracts (CE) and peptide fractions (<3 and 3-10 kDa) obtained from fermented milks with specific Lactobacillus plantarum strains...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27865264/changes-in-serum-biomarkers-of-oxidative-stress-after-treatment-for-canine-leishmaniosis-in-sick-dogs
#10
Camila Peres Rubio, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Josefa Hernández-Ruiz, Luis Pardo-Marin, Sergi Segarra, José Joaquín Ceron
Canine leishmaniosis (CanL) is a zoonotic disease being endemic in several parts of the world. In this study we investigated the behavior of a panel of biomarkers of oxidative stress in 12 sick dogs naturally infected by CanL before and at days 30 and 180 of a successful therapy with a standard treatment. The assays total oxidant status (TOS), trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma (FRAP), cupric reducing antioxidant capacity (CUPRAC), serum thiol and paraoxonase 1 (PON1) were included in the panel...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27862315/evaluation-of-salivary-nitric-oxide-levels-and-c-reactive-protein-in-patients-with-oral-lichen-planus-and-burning-mouth-syndrome
#11
Tvarijonaviciute Asta, Aznar Cayuela Cristina, Peres Rubio Camila, Ceron José Joaquin, Pia López-Jornet
OBJECTIVES: The aim of this study was to evaluate oxidative stress factors and C-reactive protein in the saliva of patients with oral lichen planus (OLP) and burning mouth syndrome (BMS). METHODS: This consecutive, cross-sectional study included 20 patients with OLP, 19 with burning mouth syndrome (BMS), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire (OHIP-14) and the Xerostomia Inventory...
November 8, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27855913/development-and-validation-of-a-near-infrared-spectrophotometric-method-to-determine-total-antioxidant-activity-of-milk
#12
G Niero, M Penasa, S Currò, A Masi, A R Trentin, M Cassandro, M De Marchi
In the present study a spectrophotometric method for the determination of total antioxidant activity (TAA) based on ABTS assay was developed and validated on raw milk (RM), whole UHT milk (WUM), partially skimmed UHT milk (SUM), whole pasteurised milk (WM) and partially skimmed pasteurised milk (SM). The most suitable solvent for antioxidant extraction was 80% acetone. Regardless of the type of milk, the coefficient of determination from the linearity test was greater than 0.95. The limit of detection ranged from 0...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27854274/the-potential-exploitation-of-the-mediterranean-invasive-alga-caulerpa-cylindracea-can-the-invasion-be-transformed-into-a-gain
#13
Loredana Stabili, Simonetta Fraschetti, Maria Immacolata Acquaviva, Rosa Anna Cavallo, Sandra Angelica De Pascali, Francesco Paolo Fanizzi, Carmela Gerardi, Marcella Narracci, Lucia Rizzo
Recently, there is a growing interest towards the development of strategies for invasive seaweed control and exploitation as source of secondary metabolites. Here, we investigated the potential of exploitation in biotechnology and recycling options in eradication programs of the lipidic extract of the Mediterranean invasive seaweed Caulerpa cylindracea (Chlorophyta). The chemical characterization was carried out by means of multinuclear and multidimensional NMR spectroscopy. The fatty acid profile of C. cylindracea assessed the presence of several types of molecules known for antioxidant activity such as carotenoids, chlorophylls, pheophytins, and sterols...
November 15, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27845706/in-vitro-investigation-of-six-antioxidants-for-pig-diets
#14
Hans Vergauwen, Sara Prims, Jeroen Degroote, Wei Wang, Christophe Casteleyn, Steven van Cruchten, Stefaan de Smet, Joris Michiels, Chris van Ginneken
Oxidative stress in the small intestinal epithelium can lead to barrier malfunction. In this study, the effect of rosmarinic acid (RA), quercetin (Que), gallic acid (GA), lipoic acid (LA), ethoxyquin (ETQ) and Se-methionine (SeMet) pre-treatments using 2 mM Trolox as a control on the viability and the generation of intracellular reactive oxygen species (iROS) of oxidatively (H₂O₂) stressed intestinal porcine epithelial cells (IPEC-J2) was investigated. A neutral red assay showed that RA (50-400 µM), Que (12...
November 11, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27823562/anti-inflammatory-and-hypolipidemic-effect-of-novel-conjugates-with-trolox-and-other-antioxidant-acids
#15
Panagiotis Theodosis-Nobelos, Panos N Kourounakis, Eleni A Rekka
OBJECTIVES: A series of esters and amides, incorporating an antioxidant residue, such as trolox or caffeic acid, and various moieties with different biological activities, were synthesised. RESULTS: The obtained compounds demonstrated considerable anti-inflammatory, radical scavenging and antioxidant action. Thus, they could reduce carrageenan-induced rat paw oedema by 31-60% at 150 μmol/kg and inhibit rat microsomal membrane lipid peroxidation with IC50 values as low as 1...
November 4, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27817090/optimization-of-physical-conditions-for-the-aqueous-extraction-of-antioxidant-compounds-from-ginger-zingiber-officinale-applying-a-box-behnken-design
#16
Juan Ramírez-Godínez, Judith Jaimez-Ordaz, Araceli Castañeda-Ovando, Javier Añorve-Morga, Verónica Salazar-Pereda, Luis Guillermo González-Olivares, Elizabeth Contreras-López
Since ancient times, ginger (Zingiber officinale) has been widely used for culinary and medicinal purposes. This rhizome possesses several chemical constituents; most of them present antioxidant capacity due mainly to the presence of phenolic compounds. Thus, the physical conditions for the optimal extraction of antioxidant components of ginger were investigated by applying a Box-Behnken experimental design. Extracts of ginger were prepared using water as solvent in a conventional solid-liquid extraction. The analyzed variables were time (5, 15 and 25 min), temperature (20, 55 and 90 °C) and sample concentration (2, 6 and 10 %)...
November 5, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27814716/the-inhibitory-activity-of-herbal-medicines-on-the-keys-enzymes-and-steps-related-to-carbohydrate-and-lipid-digestion
#17
Weerachat Sompong, Nuttapat Muangngam, Artitaya Kongpatpharnich, Chadakarn Manacharoenlarp, Chanatkarn Amorworasin, Tanyawan Suantawee, Thavaree Thilavech, Sirichai Adisakwattana
BACKGROUND: Obesity and overweight are consistently associated with metabolic disorders including hyperglycemia and hyperlipidemia. Herbal medicines have been currently suggested as an alternative source of potentially useful antihyperglycemic, antihyperlipidemic, antioxidant activities. The objective of this study was to assess the in vitro inhibitory effects of eleven herbal medicines on carbohydrate and lipid digestive enzymes and the key steps of lipid digestion including the inhibition of micelle formation and the ability to bind bile acid...
November 4, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27813595/antioxidant-activity-anti-proliferative-activity-and-amino-acid-profiles-of-ethanolic-extracts-of-edible-mushrooms
#18
S Panthong, N Boonsathorn, S Chuchawankul
Biological activities of various mushrooms have recently been discovered, particularly, immunomodulatory and antitumor activities. Herein, three edible mushrooms, Auricularia auricula-judae (AA), Pleurotus abalonus (PA) and Pleurotus sajor-caju (PS) extracted using Soxhlet ethanol extraction were evaluated for their antioxidative, anti-proliferative effects on leukemia cells. Using the Folin-Ciocalteau method and Trolox equivalent antioxidant capacity assay, phenolics and antioxidant activity were found in all sample mushrooms...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27802575/antioxidative-effects-of-a-glucose-cysteine-maillard-reaction-product-on-the-oxidative-stability-of-a-structured-lipid-in-a-complex-food-emulsion
#19
Molly J Sproston, Casimir C Akoh
A glucose-cysteine Maillard reaction product (MRP) was produced and its antioxidant effects on lipid oxidation were determined for a structured-lipid enriched with polyunsaturated fatty acids in a complex emulsion. Trolox equivalent antioxidant capacities (TEAC) were determined for MRP heating intervals of 2, 4, and 6 h and were compared to α-tocopherol (TOC), MRP with TOC (TOC-MRP), and TOC with ascorbyl palmitate (TOC-AP). Emulsions were produced with total antioxidant additions of 0.02% of the oil, and lipid oxidation was monitored by peroxide and p-anisidine values over 56 d...
November 1, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27801875/phenolic-melatonin-related-compounds-their-role-as-chemical-protectors-against-oxidative-stress
#20
REVIEW
Annia Galano, Romina Castañeda-Arriaga, Adriana Pérez-González, Dun-Xian Tan, Russel J Reiter
There is currently no doubt about the serious threat that oxidative stress (OS) poses to human health. Therefore, a crucial strategy to maintain a good health status is to identify molecules capable of offering protection against OS through chemical routes. Based on the known efficiency of the phenolic and melatonin (MLT) families of compounds as antioxidants, it is logical to assume that phenolic MLT-related compounds should be (at least) equally efficient. Unfortunately, they have been less investigated than phenols, MLT and its non-phenolic metabolites in this context...
October 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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