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https://www.readbyqxmd.com/read/28322379/wine-lees-modulate-lipid-metabolism-and-induce-fatty-acid-remodelling-in-zebrafish
#1
M Caro, A Sansone, J Amezaga, V Navarro, C Ferreri, I Tueros
This study investigates the ability of a polyphenolic extract obtained from a wine lees by-product to modulate zebrafish lipid metabolism. Lees from a Spanish winery were collected and the polyphenolic extract was chemically characterised in terms of antioxidant capacity, total phenolic content and the individual main phenolic compounds. The effects of the extract on lipid metabolism were evaluated using a zebrafish animal model. Lees are rich in polyphenols (42.33 mg gallic acid equivalent per g dry matter) with high antioxidant capacity (56...
March 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28317736/evaluation-of-phenolic-profile-and-antioxidant-capacity-in-gluten-free-flours
#2
Gabriele Rocchetti, Giulia Chiodelli, Gianluca Giuberti, Francesco Masoero, Marco Trevisan, Luigi Lucini
The characterization of phenolic fingerprints in common gluten-free flours is still scarce. Total phenolic and anthocyanin contents, antioxidant capacity and the entire phenolic profile were investigated for extracts from chickpea, sorghum, quinoa, black rice, lentil, amaranth, brown rice, oat and white rice flours, using soft wheat flour as a comparison. The highest phenolic content was found in black rice, followed by quinoa extracts (147.9 and 87.2mg gallic acid equivalents 100g(-1), respectively). Consistently, antioxidant capacity was highest in black rice and quinoa flours (34mmol trolox equivalents 100g(-1)), while anthocyanins were highest in black rice flour...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28301955/bioactive-compounds-and-antioxidants-from-a-mediterranean-garland-harvested-at-two-stages-of-maturity
#3
Leonardo Sulas, Giacomo L Petretto, Giorgio Pintore, Giovanna Piluzza
Chrysanthemum coronarium L. (garland) is an herbaceous plant rich in bioactive compounds. The chemical composition, bioactive compounds and antioxidant properties of a Mediterranean garland population were investigated in different organs at two phenological stages. Antioxidant capacity varied from 7.9 (vegetative) to 14.4 (flowering) mmol Trolox equivalent antioxidant capacity 100 g(-1) dry weight (DW). A significant correlation between antioxidant capacity and total phenolics and total flavonoids was found at flowering stage...
March 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28298149/methotrexate-induced-mitochondrial-injury-and-cytochrome-c-release-in-rat-liver-hepatocytes
#4
Abdullah Al Maruf, Peter J O'Brien, Parvaneh Naserzadeh, Rozhina Fathian, Ahmad Salimi, Jalal Pourahmad
Methotrexate (MTX) is a folic acid antagonist that is widely used to treat a variety of diseases. One of the most serious side effects of MTX therapy is hepatotoxicity. The potential molecular cytotoxic mechanisms of MTX toward isolated rat hepatocytes were investigated using Accelerated Cytotoxicity Mechanism Screening (ACMS) techniques. A concentration and time dependent increase in cytotoxicity and reactive oxygen species (ROS) formation and a decrease in mitochondrial membrane potential (MMP) were observed with MTX...
March 16, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28290328/betaxanthins-and-antioxidant-capacity-in-stenocereus-pruinosus-stability-and-use-in-food
#5
Juan A Rodríguez-Sánchez, María T Cruz Y Victoria, Blanca E Barragán-Huerta
Betalains are important pigments for the food, pharmaceutical, and cosmetics industry. In the yellow Stenocereus pruinosus fruits (pitayas), total betalain concentration, Folin-Ciocalteu reduction capacity, and antiradical capacity per dry weight were 2345.9μgg(-1), 7.3mg gallic acid equivalentsg(-1), and 48.8μmol Trolox equivalentg(-1), respectively. The stability of betaxanthins, which represent 89% of total betalains in yellow pitayas, was evaluated over a range of pH, temperature, as well as in the presence of food additives...
January 2017: Food Research International
https://www.readbyqxmd.com/read/28288261/antioxidant-capacity-and-superoxide-dismutase-activity-in-adrenoleukodystrophy
#6
Bela R Turk, Benjamin E Theisen, Christina L Nemeth, Joel S Marx, Xiaohai Shi, Melissa Rosen, Richard O Jones, Ann B Moser, Paul A Watkins, Gerald V Raymond, Carol Tiffany, Ali Fatemi
Importance: X-linked adrenoleukodystrophy (ALD) may switch phenotype to the fatal cerebral form (ie, cerebral ALD [cALD]), the cause of which is unknown. Determining differences in antioxidant capacity and superoxide dismutase (SOD) levels between phenotypes may allow for the generation of a clinical biomarker for predicting the onset of cALD, as well as initiating a more timely lifesaving therapy. Objective: To identify variations in the levels of antioxidant capacity and SOD activity between ALD phenotypes in patients with cALD or adrenomyeloneuropathy (AMN), heterozygote female carriers, and healthy controls and, in addition, correlate antioxidant levels with clinical outcome scores to determine a possible predictive value...
March 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28284186/phytochemical-compositions-of-extract-from-peel-of-hawthorn-fruit-and-its-antioxidant-capacity-cell-growth-inhibition-and-acetylcholinesterase-inhibitory-activity
#7
Panpan Wu, Fajie Li, Jianyong Zhang, Bin Yang, Zhaojie Ji, Weidong Chen
BACKGROUND: Hawthorn fruit (HF) is a well-known traditional medicine in China with the effects of improving digestion and regulating qi-flowing for removing blood stasis. Modern pharmacological experiments showed that HF extract has various pharmaceutical properties and flavonoids are considered as the main bioactive compounds. In this paper, Diaion HP-20 adsorption chromatography was used to enrich flavonoids in PHF, and the phytochemical composition of EPHF was analyzed by high performance liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC-MS)...
March 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28283081/serum-biomarkers-of-oxidative-stress-in-dogs-with-idiopathic-inflammatory-bowel-disease
#8
C P Rubio, S Martínez-Subiela, J Hernández-Ruiz, A Tvarijonaviciute, J J Cerón, K Allenspach
The objective of this work was to study and compare a panel of various serum biomarkers evaluating both the antioxidant response and oxidative damage in dogs with idiopathic inflammatory bowel disease (IBD). Eighteen dogs with IBD and 20 healthy dogs were enrolled in the study. Trolox equivalent antioxidant capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of the plasma (FRAP), total thiol concentrations, and paraoxonase 1 (PON1) activity were evaluated in serum to determine antioxidant response...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28279845/design-synthesis-and-evaluation-of-novel-ferulic-acid-o-alkylamine-derivatives-as-potential-multifunctional-agents-for-the-treatment-of-alzheimer-s-disease
#9
Zhipei Sang, Wanli Pan, Keren Wang, Qinge Ma, Lintao Yu, Yan Yang, Ping Bai, Chaoliang Leng, Qian Xu, Xiaoqing Li, Zhenghuai Tan, Wenmin Liu
A series of novel ferulic acid-O-alkylamines derivatives were designed, synthesized, and evaluated as multitarget-directed ligands against Alzheimer's disease. In vitro studies displayed that all the synthesized target compounds showed impressive inhibitory activity against butyrylcholinesterase (BuChE), significant inhibition/disaggregation of self-induced β-amyloid (Aβ) aggregation and acted as potential antioxidants. Particularly, compound 7f, one of the most potent BuChE inhibitor (IC50 value of 0.021 μM for equine serum BuChE, 8...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28278619/evaluation-of-antioxidant-and-tyrosinase-inhibitory-activities-of%C3%A2-the-extracts-of-sarcopoterium-spinosum-l-spach-fruits
#10
Alessandra Piras, Benedetta Era, Amalia Di Petrillo, Ana María González Paramás, Andrea Maxia, Alfredo Maccioni, Silvia Porcedda, Danilo Falconieri, Antonella Rosa
Sarcopoterium spinosum fruits have been used to get extracts of different nature; two fixed oils were obtained by means of supercritical fluid extraction (SFE) with CO2 at 250 bar and 40°C and using n-hexane in a Soxhlet extraction (SE) apparatus. Aqueous solutions: an aromatic water (AW) and a residual water (RW) were obtained by hydrodistillation (HD). In the RW, following have been identified: quercetin glucuronide, luteolin 7-O-glucuronide, isorhamnetin 3-O-glucuronide, quercetin sulfate and quercetin...
March 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28277068/vitamin-c-and-trolox-decrease-oxidative-stress-and-hemolysis-in-cold-stored-human-red-blood-cells
#11
Kamila Czubak, Adam Antosik, Natalia Cichon, Halina Malgorzata Zbikowska
OBJECTIVES: To investigate the effects of sodium ascorbate (SA) (5-3125 μM) and a combination of SA and Trolox (25 and 125 μM) on oxidative changes generated in red blood cells (RBCs) followed by up to 20 days refrigerated storage. METHODS: RBCs were isolated from CPD-preserved human blood. Percentage of hemolysis and extracellular activity of lactate dehydrogenase (LDH) were measured to assess the RBC membrane integrity. Lipid peroxidation (LPO), glutathione (GSH) and total antioxidant capacity (TAC) were quantified by thiobarbituric acid-reactive substances, Ellman's reagent and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) [Formula: see text]-based assay, respectively...
February 11, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28275870/synthesis-of-short-retinoidal-amides-related-to-fenretinide-antioxidant-activities-and-differentiation-inducing-ability
#12
Maria Anzaldi, Maurizio Viale, Chiara Macciò, Patrizio Castagnola, Valentina Oliveri, Camillo Rosano, Alessandro Balbi
PURPOSE: By a scaffold shortening strategy, a small series of retinoidal amides fenretinide (4-HPR) analogs have been synthesized from α, β-ionones and tested for their antiproliferative and differentiating activities, and antioxidant effect. METHODS: The antiproliferative activity and triggering of apoptosis of our short retinoids were evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and 4'-6-diamidino-2-phenylindole staining and microscope evaluation after 3- or 6-day exposure, while their differentiating activity was established by the analysis of the expression of the CD11b marker of differentiation in treated HL60 target cells and by the superoxide production assayed colorimetrically by the nitro blue tetrazolium-reducing activity assay...
March 9, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28273843/effect-of-leaves-of-caesalpinia-decapetala-on-oxidative-stability-of-oil-in-water-emulsions
#13
María Gabriela Gallego, Monika Skowyra, Michael H Gordon, Nurul Aini Mohd Azman, María Pilar Almajano
Caesalpinia decapetala (Roth) Alston (Fabaceae) (CD) is used in folk medicine to prevent colds and treat bronchitis. This plant has antitumor and antioxidant activity. The antioxidant effects of an extract from Caesalpinia decapetala (Fabaceae) were assessed by storage of model food oil-in-water emulsions with analysis of primary and secondary oxidation products. The antioxidant capacity of the plant extract was evaluated by the diphenylpicrylhydrazyl (DPPH), Trolox equivalent antioxidant capacity (TEAC), oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays and by electron paramagnetic resonance (EPR) spectroscopy...
March 4, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28272477/chemosensitivity-of-mcf-7-cells-to-eugenol-release-of-cytochrome-c-and-lactate-dehydrogenase
#14
Rana Al Wafai, Warde El-Rabih, Meghri Katerji, Remi Safi, Marwan El Sabban, Omar El-Rifai, Julnar Usta
Phytochemicals have been extensively researched for their potential anticancer effects. In previous study, direct exposure of rat liver mitochondria to eugenol main ingredient of clove, uncoupled mitochondria and increased F0F1ATPase activity. In the present study, we further investigated the effects of eugenol on MCF-7 cells in culture. Eugenol demonstrated: a dose-dependent decrease in viability (MTT assay), and proliferation (real time cell analysis) of MCF-7 cells, (EC50: 0.9 mM); an increase in reactive oxygen species; a decrease in ATP level and mitochondrial membrane potential (MitoPT JC-1 assay); and a release of cytochrome-c and lactate dehydrogenase (Cytotoxicity Detection Kit (PLUS)) into culture media at eugenol concentration >EC50...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28272313/optimization-of-ultrasonic-assisted-enzymatic-extraction-conditions-for-improving-total-phenolic-content-antioxidant-and-antitumor-activities-in-vitro-from-trapa-quadrispinosa-roxb-residues
#15
Feng Li, Yi-Dan Mao, Yi-Fan Wang, Aun Raza, Li-Peng Qiu, Xiu-Quan Xu
Stems are the important residues of Trapa quadrispinosa Roxb., which are abundant in phenolic compounds. Ultrasonic-assisted enzymatic extraction (UAEE) is confirmed as a novel extraction technology with main advantages of enhancing extraction yield and physiological activities of the extracts from various plants. In this study, UAEE was applied to obtain the highest yield of phenolic content, strongest antioxidant, and antitumor activities and to optimize the extraction conditions using response surface methodology (RSM)...
March 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28267485/three-phase-partitioning-for-efficient-extraction-and-separation-of-polysaccharides-from-corbicula-fluminea
#16
Jing-Kun Yan, Yao-Yao Wang, Wen-Yi Qiu, Ning Shao
Three-phase partitioning (TPP), which is a simple, efficient, and green bioseparation technique, was used to extract and separate polysaccharides from Corbicula fluminea (CFPS). The optimal parameters with a high yield of 9.32% were as follows: mass fraction of (NH4)2SO4, 20.0% (w/v); amount of t-butanol, 9.8mL; temperature, 35.3°C; extraction time, 30min; and pH 6.0. The purified CFPS after TPP consisted of d-glucose, d-glucosamine, and d-mannose in a molar ratio of 57.1: 5.6:1.0 with high purity (86.5%) and different molecular weights (1311...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28265357/antioxidant-potential-of-juglans-nigra-black-walnut-husks-extracted-using-supercritical-carbon-dioxide-with-an-ethanol-modifier
#17
Jonathan Wenzel, Cheryl Storer Samaniego, Lihua Wang, Laron Burrows, Evan Tucker, Nathan Dwarshuis, Michelle Ammerman, Ali Zand
The black walnut, Junglas nigra, is indigenous to eastern North America, and abscission of its fruit occurs around October. The fruit consists of a husk, a hard shell, and kernel. The husk is commonly discarded in processing, though it contains phenolic compounds that exhibit antioxidant and antimicrobial properties. For this study, black walnut husks were extracted using supercritical carbon dioxide with an ethanol modifier. The effects of temperature, ethanol concentration, and drying of walnut husks prior to extraction upon antioxidant potential were evaluated using a factorial design of experiments...
March 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28263542/smartphone-based-colorimetric-detection-of-glutathione
#18
Irena Vobornikova, Miroslav Pohanka
OBJECTIVES: Glutathione belongs to the family of small-molecular weight antioxidants like ascorbic acid, cysteine, α-tocopherol, uric acid, etc. These molecules play important role in the neutralization of free radicals and reactive oxygen species (ROS). Oxidative stress may lead to ageing and the development of large scale of pathological states of organism. This low molecular weight antioxidant´s level can alter under pathological conditions from reduced (GSH, thiols) to oxidized (oxidized glutathione -GSSG, disulfides) form...
December 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28257062/antioxidant-activity-of-the-lignins-derived-from-fluidized-bed-fast-pyrolysis
#19
Sohail S Qazi, Dongbing Li, Cedric Briens, Franco Berruti, Mamdouh M Abou-Zaid
A challenge in recent years has been the rational use of forest and agriculture residues for the production of bio-fuel, biochemical, and other bioproducts. In this study, potentially useful compounds from pyrolytic lignins were identified by HPLC-MS/MS and untargeted metabolomics. The metabolites identified were 2-(4-allyl-2-methoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)-1-propanol, benzyl benzoate, fisetinidol, phenyllactic acid, 2-phenylpropionic acid, 6,3'-dimethoxyflavone, and vanillin. The 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH), trolox equivalent antioxidant capacity (TEAC), and total phenolics content (TPC) per gram of pyrolytic lignin ranged from 14 to 503 mg ascorbic acid equivalents, 35 to 277 mg trolox equivalents, and 0...
March 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28247212/pyruvate-antioxidant-roles-in-human-fibroblasts-and-embryonic-stem-cells
#20
Priscila Ramos-Ibeas, Maria Barandalla, Silvia Colleoni, Giovanna Lazzari
Oxidative stress has been related to multiple diseases, especially during early embryonic development, when environmental alterations can lead to long-term deleterious effects. In vitro studies of oxidative stress have been mainly focused on somatic cells, but embryonic stem cells (ESCs) represent a promising model of early embryonic development as they are the in vitro equivalent to pluripotent cells in the embryo. Human fibroblasts and ESCs were exposed to different pro-oxidant agents (hydrogen peroxide, tert-butyl hydroperoxide (TBHP), and rotenone) and antioxidants (sodium pyruvate, N-acetylcysteine, Trolox, and sodium selenite) during a 72 h oxidative stress treatment...
February 28, 2017: Molecular and Cellular Biochemistry
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