Heike A Bischoff-Ferrari, Bruno Vellas, René Rizzoli, Reto W Kressig, José A P da Silva, Michael Blauth, David T Felson, Eugene V McCloskey, Bernhard Watzl, Lorenz C Hofbauer, Dieter Felsenberg, Walter C Willett, Bess Dawson-Hughes, JoAnn E Manson, Uwe Siebert, Robert Theiler, Hannes B Staehelin, Caroline de Godoi Rezende Costa Molino, Patricia O Chocano-Bedoya, Lauren A Abderhalden, Andreas Egli, John A Kanis, Endel J Orav
IMPORTANCE: The benefits of vitamin D, omega-3 fatty acids, and exercise in disease prevention remain unclear. OBJECTIVE: To test whether vitamin D, omega-3s, and a strength-training exercise program, alone or in combination, improved 6 health outcomes among older adults. DESIGN, SETTING, AND PARTICIPANTS: Double-blind, placebo-controlled, 2 × 2 × 2 factorial randomized clinical trial among 2157 adults aged 70 years or older who had no major health events in the 5 years prior to enrollment and had sufficient mobility and good cognitive status...
November 10, 2020: JAMA