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https://www.readbyqxmd.com/read/27910973/multiphase-transition-of-supramolecular-metallogels-triggered-by-temperature
#1
Bo Jiang, Li-Jun Chen, Guang-Qiang Yin, Yu-Xuan Wang, Wei Zheng, Lin Xu, Hai-Bo Yang
We present a new family of supramolecular metallogels undergoing reversible multiphase transition triggered by temperature from amphiphilic alkynylplatinum(ii) complexes. Further investigation revealed that intermolecular PtPt and π-π stacking interactions facilitate such phase transitions upon increasing the temperature.
December 2, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27910895/arabidopsis-thaliana-as-a-suitable-model-host-for-research-on-interactions-between-plant-and-foliar-nematodes-parasites-of-plant-shoot
#2
Dong-Wei Wang, Xiao-Fang Peng, Hui Xie, Chun-Ling Xu, De-Qiang Cheng, Jun-Yi Li, Wen-Jia Wu, Ke Wang
The rice white tip nematode (RWTN), Aphelenchoides besseyi and the chrysanthemum foliar nematode (CFN), Aphelenchoides ritzemabosi are migratory plant parasitic nematodes that infect the aboveground parts of plants. In this research, Arabidopsis thaliana was infected by RWTN and CFN under indoor aseptic cultivation, and the nematodes caused recognizable symptoms in the leaves. Furthermore, RWTN and CFN completed their life cycles and proliferated. Therefore, A. thaliana was identified as a new host of RWTN and CFN...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910073/a-polarization-dependent-normal-incident-quantum-cascade-detector-enhanced-via-metamaterial-resonators
#3
Lei Wang, Shen-Qiang Zhai, Feng-Jiao Wang, Jun-Qi Liu, Shu-Man Liu, Ning Zhuo, Chuan-Jin Zhang, Li-Jun Wang, Feng-Qi Liu, Zhan-Guo Wang
The design, fabrication, and characterization of a polarization-dependent normal incident quantum cascade detector coupled via complementary split-ring metamaterial resonators in the infrared regime are presented. The metamaterial structure is designed through three-dimensional finite-difference time-domain method and fabricated on the top metal contact, which forms a double-metal waveguide together with the metallic ground plane. With normal incidence, significant enhancements of photocurrent response are obtained at the metamaterial resonances compared with the 45° polished edge coupling device...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27909714/inhibition-of-cdh17-gene-expression-via-rna-interference-reduces-proliferation-and-apoptosis-of-human-mkn28-gastric-cancer-cells
#4
Rui Li, Hong-Qiang Yang, Hai-Lin Xi, Su Feng, Rui-Hao Qin
Gastric cancer is the fourth most common type of cancer and the second cause of cancer‑related mortalities worldwide despite the use of multimodal therapy. Cadherins are transmembrane glycoproteins that are involved in tumorigenesis. CDH17 has been found to be over‑expressed in gastric cancer and its overexpression was associated with lymph node metastasis and tumor‑node‑metastasis stage of the patients, yet the exact role and molecular mechanism of CDH17 in gastric cancer have not been determined. Using a lentiviral system as a delivery mediator of RNA interference, we found that inhibition of CDH17 can lead to reduce proliferation and increase apoptosis of gastric cancer cell line MKN28 in vitro and significantly diminish their tumorigenicity in vivo...
November 28, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27909649/in-silico-profiling-of-cell-growth-and-succinate-production-in-escherichia-coli-nzn111
#5
Xingxing Jian, Ningchuan Li, Cheng Zhang, Qiang Hua
BACKGROUND: Succinic acid is a valuable product due to its wide-ranging utilities. To improve succinate production and reduce by-products formation, Escherichia coli NZN111 was constructed by insertional inactivation of lactate dehydrogenase (LDH) and pyruvate formate lyase (PFL) encoded by the genes ldhA and pflB, respectively. However, this double-deletion mutant is incapable of anaerobically growing on glucose in rich or minimal medium even with acetate supplementation. A widespread hold view is that the inactivation of NADH-dependent LDH limits the regeneration of NAD(+) and consequently disables proper growth under anaerobic conditions...
2016: Bioresources and Bioprocessing
https://www.readbyqxmd.com/read/27908726/activation-of-g-protein-coupled-estrogen-receptor-1-improves-early-onset-cognitive-impairment-via-pi3k-akt-pathway-in-rats-with-traumatic-brain-injury
#6
Ze-Fen Wang, Zhi-Yong Pan, Cheng-Shi Xu, Zhi-Qiang Li
Previous studies experimentally reveal that G-protein coupled estrogen receptor 1(GPER) has neuroprotection against ischemic injury. However, its effect on traumatic brain injury (TBI) is less well-established. Cognitive impairment following human TBI is a common clinical observation, and TBI is considered as a risk factor for Alzheimer's disease (AD). This study aimed to observe the possible protective effect of GPER on early-onset cognitive impairment after a single TBI and investigate the cellular mechanism underlying its actions...
November 28, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27907216/correction-deciphering-transcriptome-and-complex-alternative-splicing-transcripts-in-mammary-gland-tissues-from-cows-naturally-infected-with-staphylococcus-aureus-mastitis
#7
Xiu Ge Wang, Zhi Hua Ju, Ming Hai Hou, Qiang Jiang, Chun Hong Yang, Yan Zhang, Yan Sun, Rong Ling Li, Chang Fa Wang, Ji Feng Zhong, Jin Ming Huang
[This corrects the article DOI: 10.1371/journal.pone.0159719.].
2016: PloS One
https://www.readbyqxmd.com/read/27906672/non-toxic-dose-of-liposomal-honokiol-suppresses-metastasis-of-hepatocellular-carcinoma-through-destabilizing-egfr-and-inhibiting-the-downstream-pathways
#8
Jianhong Yang, Heying Pei, Hong Luo, Afu Fu, Hansuo Yang, Jia Hu, Chengjian Zhao, LuLu Chai, Xiang Chen, Ximing Shao, Chunyu Wang, Wenshuang Wu, Li Wan, Haoyu Ye, Qiang Qiu, Aihua Peng, Yuquan Wei, Li Yang, Lijuan Chen
At present, there is no specific anti-metastasis drug in HCC treatment. Drugs used for primary HCC tumors and tumor metastasis are very similar, among which cytotoxic drugs are prevalent, such as cisplatin, doxorubicin and 5-FU. The EGFR pathway plays an important role in promoting hepatocellular carcinoma (HCC) metastasis. Hence, development of non-toxic anti-metastasis drugs, such as EGFR or downstream pathways inhibitors, is of great importance. In our present study, we found non-toxic dose of liposomal honokiol (LH) could inhibit the HCC metastasis by destabilizing EGFR and inhibiting the downstream pathways...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27906248/experimental-measurement-device-independent-quantum-key-distribution-with-uncharacterized-encoding
#9
Chao Wang, Shuang Wang, Zhen-Qiang Yin, Wei Chen, Hong-Wei Li, Chun-Mei Zhang, Yu-Yang Ding, Guang-Can Guo, Zheng-Fu Han
Measurement-device-independent quantum key distribution (MDI QKD) is an efficient way to share secrets using untrusted measurement devices. However, the assumption on the characterizations of encoding states is still necessary in this promising protocol, which may lead to unnecessary complexity and potential loopholes in realistic implementations. Here, by using the mismatched-basis statistics, we present the first proof-of-principle experiment of MDI QKD with uncharacterized encoding sources. In this demonstration, the encoded states are only required to be constrained in a two-dimensional Hilbert space, and two distant parties (Alice and Bob) are resistant to state preparation flaws even if they have no idea about the detailed information of their encoding states...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27905612/bulky-4-6-disubstituted-tetraphenylethene-naphthalimide-dyad-synthesis-copolymerization-stimuli-responsive-fluorescence-and-cellular-imaging
#10
Qiong-Xin Hua, Bo Xin, Jun-Xia Liu, Ling-Xi Zhao, Zu-Jing Xiong, Tao Chen, Ze-Qiang Chen, Chong Li, Wen-Liang Gong, Zhen-Li Huang, Ming-Qiang Zhu
We report the design and synthesis of a tetraphenylethene substituted with naphthalimide at the 4, 6 positions, named NI-2TPE. NI-2TPE exhibits strong solvent-dependent emission properties with combined ICT and AIE characteristics in THF-H2O systems. This probe was used directly on test papers to distinguish normal organic solvents using their emission colours under UV light based on its AIE and ICT nature. Thanks to the vinyl group in NI-2TPE, we synthesized a copolymer of NIPAM and NI-2TPE, termed P(NIPAM-co-NI-2TPE)...
December 1, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27904780/low-expression-of-rbms3-and-sfrp1-are-associated-with-poor-prognosis-in-patients-with-gastric-cancer
#11
Tao Zhang, Youliang Wu, Zheng Fang, Qiang Yan, Shangxin Zhang, Ruochuan Sun, Junaid Khaliq, Yongxiang Li
RNA binding motif, single stranded interacting protein 3 (RBMS3) has been reported as a tumor suppressor gene (TSG) in some squamous carcinoma. However, its expression levels and clinical significance in gastric cancer (GC) remains unclear. Secreted frizzled-related protein 1 (SFRP1) plays a role of tumor suppressor in many cancers by inhibiting Wnt/β-catenin pathway. Nevertheless, its expression levels and clinical significance in GC are in dispute. In this study, quantitative real-time PCR and Western Blot were used to measure the mRNA and protein level of RBMS3 and SFRP1 in 23 fresh GC and corresponding normal tissues...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27902487/identification-of-laryngeal-cancer-prognostic-biomarkers-using-an-inflammatory-gene-related-competitive-endogenous-rna-network
#12
Qun He, Linli Tian, Hao Jiang, Jiarui Zhang, Qiang Li, Yanan Sun, Jiannan Zhao, Huijun Li, Ming Liu
Competitive endogenous RNAs (ceRNAs) act as molecular sponges for microRNAs (miRNAs), and are associated with tumorigenesis in various cancers, including laryngeal cancer (LC). In this work, we constructed an LC-specific inflammatory gene-related ceRNA network (IceNet). In IceNet, ceRNAs targeting inflammation-related genes tended to be network hubs. Additionally, the betweenness centralities of these hub ceRNAs were higher than those of the inflammation-related genes themselves, indicating that the hub ceRNAs in this study played critical roles in communication between IceNet molecules...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27902481/association-of-smoking-status-with-prognosis-in-bladder-cancer-a-meta-analysis
#13
Lina Hou, Xuwei Hong, Meng Dai, Pengliang Chen, Hongfan Zhao, Qiang Wei, Fei Li, Wanlong Tan
There is considerable controversy regarding the association between smoking and prognosis in surgically treated bladder cancer. The present meta-analysis was performed to quantify the role of smoking status in bladder cancer recurrence, progression and patient survival by pooling the available previous data. Pubmed, Embase and the Cochrane Library databases were searched for eligible studies published prior to April 2016. Random and fixed effects models were used to calculate the summary relative risk estimates (SRRE)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27902480/down-regulation-of-rna-binding-motif-single-stranded-interacting-protein-3-along-with-up-regulation-of-nuclear-hif1a-correlates-with-poor-prognosis-in-patients-with-gastric-cancer
#14
Youliang Wu, Dapeng Yun, Yingjie Zhao, Yuqi Wang, Ruochuan Sun, Qiang Yan, Shangxin Zhang, Mingdian Lu, Zhen Zhang, Daru Lu, Yongxiang Li
Frequent loss of multiple regions in short arm of chromosome 3 is found in various tumors including gastric cancer (GC). RNA binding motif, single-stranded interacting protein 3 (RBMS3) is a tumor suppressor gene located in this region and mediates cancer angiogenesis. However, the role of RBMS3 in GC remains unclear.To evaluate whether RBMS3, together with HIF1A, another key regulator of angiogenesis, predicts GC prognosis, the levels of RBMS3 and HIF1A were first examined by quantitative PCR (qPCR) and western blot from 27 fresh frozen GC and paired normal gastric tissues and then tested by immunohistochemistry (IHC) from 191 GC and 46 normal controls...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900880/associations-of-nicotinamide-n-methyltransferase-gene-single-nucleotide-polymorphisms-with-sport-performance-and-relative-maximal-oxygen-uptake
#15
Jiang-Hua Li, Wei Chen, Xiao-Juan Zhu, Ya-Jun Lin, Li-Qiang Qiu, Can-Xin Cai, Ya-Hui Wang, Qun Xiong, Fei Chen, Li-Hui Chen
To observe the associations between single nucleotide polymorphisms (SNPs) of nicotinamide N-methyltransferase (NNMT) gene and sport performance and to analyse genotype associations of the associated SNPs with sport performance and relative maximal oxygen uptake ([Formula: see text]). Participants were selected from 685 Chinese Han male college students. The completion times of a 1000-m run and a 50-m run were used to reflect sport performance, respectively. Nineteen tagSNPs were genotyped with Polymerase chain reaction-ligase detection reaction...
November 30, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27899850/evaluation-of-short-and-long-term-efficacy-of-combined-intracoronary-administration-of-high-dose-adenosine-and-tirofiban-during-primary-percutaneous-coronary-intervention
#16
Yanbing Li, Qiang Li, Feiou Li, Min Zong, Guobin Miao, Xinchun Yang, Zichuan Tong, Jianjun Zhang
BACKGROUND: To assess the influence of combined intracoronary application of high-dose adenosine and tirofiban in primary percutaneous coronary intervention (PCI) on clinical events and cardiac function. METHODS: Our study evaluated consecutive patients with acute ST-segment elevation myocardial infarction undergoing primary PCI, who were randomly divided into adenosine group (n = 130) and control group (n = 128). Combined with thrombus aspiration and then intracoronary tirofiban, the adenosine group received intracoronary adenosine (2 mg) through the aspiration catheter 2 times...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27899323/comparison-of-endoscopic-submucosal-tunneling-dissection-and-thoracoscopic-enucleation-for-the-treatment-of-esophageal-submucosal-tumors
#17
Qing-Yuan Li, Yu-Yuan Xu, Wei Gong, Qiang Zang, Jian-Qun Cai, Haitao Qing, Zelong Han, Aimin Li, Si-de Liu, Yue Li
BACKGROUND: Endoscopic submucosal tunneling dissection (ESTD) has been proved to be safe and effective for removal of esophageal submucosal tumors (SMTs) and can maintain the mucosal integrity compared with other endoscopic methods. The aim of the study was to estimate the safety and efficacy of ESTD as well as compare its efficacy with thoracoscopic enucleation for esophageal SMTs, which is used increasingly as a minimally invasive approach. METHODS: We retrospectively collected the clinical data of the patients with esophageal SMTs smaller than 40 mm who underwent ESTD or thoracoscopic enucleation at Nanfang hospital between January 2008 and August 2016...
November 26, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27899252/the-effects-of-metronidazole-on-cytochrome-p450-activity-and-expression-in-rats-after-acute-exposure-to-high-altitude-of-4300m
#18
Rong Wang, Yuhuan Sun, Qiang Yin, Hua Xie, Wenbin Li, Chang Wang, Jiankui Guo, Ying Hao, Rui Tao, Zhengping Jia
BACKGROUND: The purpose is to observe the changes of CYP450 enzyme activity expression as well as the physiological and pathological states of Wistar rats given metronidazole drug intervention after acute exposure to high altitude of 4300m. METHODS AND RESULTS: Thirty healthy adult male Wistar rats of average weight 200 ± 20 g were randomly assigned into three groups of 10 rats per group as follows: Group A (55m), Group B (4300m) and Group C (metronidazole intervention, 4300m)...
November 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27899251/improved-breast-cancer-cell-specific-intracellular-drug-delivery-and-therapeutic-efficacy-by-coupling-decoration-with-cell-penetrating-peptide-and-sp90-peptide
#19
Li-Qiang Fan, Guo-Xiu Du, Peng-Fei Li, Ming-Wei Li, Yao Sun, Li-Ming Zhao
Lack of satisfactory specificity towards tumor cells and poor intracellular delivery efficacy are the major drawbacks with conventional cancer chemotherapy. Conjugated anticancer drugs to targeting moieties e.g. to peptides with the ability to recognize cancer cells and to cell penetrating peptide can improve these characteristics, respectively. Combining a tumor homing peptide with an appropriate cell-penetrating peptide can enhance the tumor-selective internalization efficacy of the carrying cargo molecules...
November 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27899147/top-classic-citations-in-pancreatic-cancer-research
#20
Qiang Li, Yuan Jiang
BACKGROUND: The number of times that articles are cited by is widely used to evaluate the impact of an article or an individual author has on its scientific community. This bibliometric analysis aimed to explore the top classic citations in pancreatic cancer (PC) research. METHODS: A computerized literature search was conducted using the database, the Science Citation Index Expanded. The top 100 highly cited articles were included and further analyzed. RESULTS: The most cited article had 3,032 citations, with a mean of 626 citations per paper...
November 29, 2016: World Journal of Surgical Oncology
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