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https://www.readbyqxmd.com/read/28922551/lectin-bs-i-inhibits-cell-migration-and-invasion-via-akt-gsk-3%C3%AE-%C3%AE-catenin-pathway-in-hepatocellular-carcinoma
#1
Qiang Jian, Zhao Yang, Jian Shu, Xiawei Liu, Jing Zhang, Zheng Li
Hepatocellular carcinoma (HCC) is most common malignant cancer worldwide; however, the mortality rate of HCC remains high due to the invasion and metastasis of HCC. Thus, exploring novel treatments to prevent the invasion of HCC is needed for improving clinical outcome of this fatal disease. In this study, we identified lectin from Bandeiraea simplicifolia seeds (BS-I) binds to metastasis-associated HCC cell surface glycans by a lectin microarray and inhibits HCC cell migration and invasion through downregulating the matrix metalloproteinase 2 (MMP2), matrix metalloproteinase 9 (MMP9) and urokinase-type plasminogen activator (uPA) production...
September 18, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28921741/chalcogen-atom-annulated-perylene-diimide-trimers-for-highly-efficient-nonfullerene-polymer-solar-cells
#2
Yuwei Duan, Xiaopeng Xu, Ying Li, Zuojia Li, Qiang Peng
This communication reports the synthesis of two novel chalcogen-atom-annulated perylene diimide (PDI) trimers with twisted structures, TriPDI-S and TriPDI-Se, for efficient nonfullerene polymer solar cells. TriPDI-Se exhibits more compact molecular arrangement due to the stronger intermolecular interactions induced by the selenium atom. This selenium annulation endows TriPDI-Se with improved absorption and crystallinity in its blend film. The resulting devices exhibit enhanced Jsc of 17.15 mA cm(-2) and fill factor (FF) of 66...
September 15, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28920113/double-1-4-addition-of-thio-salicylamides-thiosalicylic-acids-with-propiolate-derivatives-a-direct-general-synthesis-of-diverse-heterocyclic-scaffolds
#3
Hui-Hong Wang, Tao Shi, Wei-Wei Gao, Hong-Hua Zhang, Yong-Qiang Wang, Jun-Fang Li, Yong-Sheng Hou, Jin-Hong Chen, Xue Peng, Zhen Wang
A simple and practical ring-closure procedure to prepare a range of diverse heterocycles has been developed. In this transformation, a variety of substituted (thio)salicylamides and thiosalicylic acids undergo a double 1,4-addition reaction with propiolate derivatives in the presence of an inorganic base (K3PO4), as a result benzothiazinones, benzoxazinones and benzoxathiinones were prepared in good to excellent yields, respectively, even in gram scales. In addition, further transformation towards more complex structures and oxicam drug analogues has also been successfully carried out...
September 18, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28917922/the-effects-of-lotus-root-amylopectin-on-the-formation-of-whey-protein-isolate-gels
#4
Kang Liu, Qiang-Ming Li, Li-Hua Pan, Xin-Ping Qian, Hai-Lin Zhang, Xue-Qiang Zha, Jian-Ping Luo
The effects of lotus root amylopectin (LRA) on the formation of whey protein isolate (WPI) gels were investigated at the concentration range from 0 to 1.0% (w/v) by determining the texteral, thermal and rheological properties. Results exhibited these properties of WPI gels could be significantly enhanced by the addition of LRA in a concentration-dependent manner. Compared the gel with free of starch, the gel strength, water holding capacity and thermal transition temperature of WPI gel containing 1% (w/v) amylopectin were enhanced by 12...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28916760/responses-of-lai-to-rainfall-explain-contrasting-sensitivities-to-carbon-uptake-between-forest-and-non-forest-ecosystems-in-australia
#5
Longhui Li, Ying-Ping Wang, Jason Beringer, Hao Shi, James Cleverly, Lei Cheng, Derek Eamus, Alfredo Huete, Lindsay Hutley, Xingjie Lu, Shilong Piao, Lu Zhang, Yongqiang Zhang, Qiang Yu
Non-forest ecosystems (predominant in semi-arid and arid regions) contribute significantly to the increasing trend and interannual variation of land carbon uptake over the last three decades, yet the mechanisms are poorly understood. By analysing the flux measurements from 23 ecosystems in Australia, we found the the correlation between gross primary production (GPP) and ecosystem respiration (Re) was significant for non-forest ecosystems, but was not for forests. In non-forest ecosystems, both GPP and Re increased with rainfall, and, consequently net ecosystem production (NEP) increased with rainfall...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916736/silencing-of-urothelial-carcinoma-associated-1-inhibits-the-proliferation-and-migration-of-medulloblastoma-cells
#6
Xie Zhengyuan, Xiao Hu, Wang Qiang, Li Nanxiang, Cai Junbin, Zhang Wangming
BACKGROUND UCA1 is a long non-coding RNA that has been found to be aberrantly upregulated in various cancers. The aim of this study was to determine the expression level and function of UCA1 in medulloblastoma, the most common malignant brain tumor during childhood. MATERIAL AND METHODS Real-time PCR was used to detect the expression of UCA1 in medulloblastoma specimens and cell lines. Lentiviral-mediated expression of a short hairpin RNA (shRNA) targeting UCA1 or a negative control shRNA was also achieved with the medulloblastoma cell line, Daoy...
September 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28916407/corrigendum-to-circumventing-intratumoral-heterogeneity-to-identify-potential-therapeutic-targets-in-hepatocellular-carcinoma-j-hepatol-67-2017-293-301
#7
Ao Huang, Xin Zhao, Xin-Rong Yang, Fu-Qiang Li, Xin-Lan Zhou, Kui Wu, Xin Zhang, Qi-Man Sun, Ya Cao, Hong-Mei Zhu, Xiang-Dong Wang, Huan-Ming Yang, Jian Wang, Zhao-You Tang, Yong Hou, Jia Fan, Jian Zhou
No abstract text is available yet for this article.
September 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28915800/association-of-body-mass-index-with-amnestic-and-non-amnestic-mild-cognitive-impairment-risk-in-elderly
#8
Feng Wang, Minghui Zhao, Zhaoli Han, Dai Li, Shishuang Zhang, Yongqiang Zhang, Xiaodong Kong, Ning Sun, Qiang Zhang, Ping Lei
BACKGROUND: Previous studies focused on the relationship between body mass index and cognitive disorder and obtained many conflicting results. This study explored the potential effects of body mass index on the risk of mild cognitive impairment (amnestic and non-amnestic) in the elderly. METHODS: The study enrolled 240 amnestic mild cognitive impairment patients, 240 non-amnestic mild cognitive impairment patients and 480 normal cognitive function controls. Data on admission and retrospective data at baseline (6 years ago) were collected from their medical records...
September 15, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28915661/small-molecular-floribundiquinone-b-derived-from-medicinal-plants-inhibits-acetylcholinesterase-activity
#9
Bing Niu, Mengying Zhang, Pu Du, Li Jiang, Rui Qin, Qiang Su, Fuxue Chen, Dongshu Du, Yilai Shu, Kuo-Chen Chou
Being a neurodegenerative disorder, Alzheimer's disease (AD) is the one of the most terrible diseases. And acetylcholinesterase (AChE) is considered as an important target for treating AD. Acetylcholinesterase inhibitors (AChEI) are considered to be one of the effective drugs for the treatment of AD. The aim of this study is to find a novel potential AChEI as a drug for the treatment of AD. In this study, instead of using the synthetic compounds, we used those extracted from plants to investigate the interaction between floribundiquinone B (FB) and AChE by means of both the experimental approach such as fluorescence spectra, ultraviolet-visible (UV-vis) absorption spectrometry, circular dichroism (CD) and the theoretical approaches such as molecular docking...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915647/necroptosis-as-a-potential-therapeutic-target-in-multiple-organ-dysfunction-syndrome
#10
Yao-Li Cui, Li-Hua Qiu, Shi-Yong Zhou, Lan-Fang Li, Zheng-Zi Qian, Xian-Ming Liu, Hui-Lai Zhang, Xiu-Bao Ren, Yong-Qiang Wang
PURPOSE: To investigate how necroptosisis, i.e. programmed necrosis, is involved in MODS, and to examine whether Nec-1, a specific necroptosis inhibitor, ameliorates multiorgan injury in MODS. EXPERIMENTAL DESIGN: A model of MODS was established in six-week old SD rats using fracture trauma followed by hemorrhage. Control animals received sham surgery. Cell death form and necrosome formation were measured by fluorescence-activated cell sorting and western blotting...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915581/up-regulation-of-linc00161-correlates-with-tumor-migration-and-invasion-and-poor-prognosis-of-patients-with-hepatocellular-carcinoma
#11
Li-Chao Xu, Quan-Ning Chen, Xi-Qiang Liu, Xiao-Ming Wang, Qi-Meng Chang, Qi Pan, Lu Wang, Yi-Lin Wang
Accumulating evidence suggested that long non-coding RNAs (lncRNAs) play essential roles in various biological processes, including tumorigenesis. Aberrant expression of LINC00161 has been reported in some cancer types, however, the association of LINC00161 and hepatocellular carcinoma (HCC) has not been evaluated. Here, we measured the expression of LINC00161 in HCC tissues and corresponding normal liver tissues using real-time PCR. The result showed that the expression level of LINC00161 was significantly higher in HCC tissues...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915379/study-on-the-oxygen-reduction-reaction-catalyzed-by-a-cold-tolerant-marine-strain-phylogenetically-related-to-erythrobacter-citreus
#12
Lianqiang Li, Fei Ding, Lin Sang, Jiaquan Liu, Duolu Mao, Xingjiang Liu, Qiang Xu
As the development of marine economy, the submarine battery with the seawater electrolyte has obtained more and more attentions. Owing to the conventional electrochemical catalysts of the cathodes in seawater battery are expensive, it is to seek the new biological catalysts to improve the electrochemical performance of the cathode and reduce the cost of seawater battery. A novel marine bacterial strain (Strain SQ-32) phylogenetically related to the Erythrobactercitreus strain has been isolated from the sea-bed sludge in the Yellow Sea of China successfully...
September 8, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28914895/experimental-generation-of-discrete-ultraviolet-wavelength-by-cascaded-intermodal-four-wave-mixing-in-a-multimode-photonic-crystal-fiber
#13
Jinhui Yuan, Zhe Kang, Feng Li, Xianting Zhang, Chao Mei, Guiyao Zhou, Xinzhu Sang, Qiang Wu, Binbin Yan, Xian Zhou, Kangping Zhong, Kuiru Wang, Chongxiu Yu, Gerald Farrell, Chao Lu, Hwa Yaw Tam, P K A Wai
In this Letter, we demonstrate experimentally for the first time, to the best of our knowledge, discrete ultraviolet (UV) wavelength generation by cascaded intermodal FWM when femtosecond pump pulses at 800 nm are launched into the deeply normal dispersion region of the fundamental guided mode of a multimode photonic crystal fiber (MPCF). For pump pulses at average input powers of Pav=450, 550, and 650 mW, the first anti-Stokes waves are generated at the visible wavelength of 538.1 nm through intermodal phase matching between the fundamental and second-order guided mode of the MPCF...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28914716/diagnostic-utility-of-satb2-in-metastatic-krukenberg-tumors-of-the-ovary-an-immunohistochemical-study-of-70-cases-with-comparison-to-cdx2-ck7-ck20-chromogranin-and-synaptophysin
#14
Chen Yang, Li Sun, Lingxin Zhang, Lixin Zhou, Ming Zhao, Yan Peng, Dongfeng Niu, Zhongwu Li, Xiaozheng Huang, Qiang Kang, Lin Jia, Jinping Lai, Dengfeng Cao
SATB2 is a sensitive marker for colorectal adenocarcinomas. No study has investigated its diagnostic utility in metastatic Krukenberg tumors (MKTs) of the ovary. Here we performed immunohistochemical staining SATB2 in 70 MKTs of various origins (stomach 27, colorectum 13, appendix 20 including 19 metastatic adenocarcinomas ex goblet cell carcinoids [AdexGCC] and 1 conventional poorly differentiated carcinoma with signet ring cells, breast 5, bladder 3, lung 2) to assess its diagnostic utility. We also compared SATB2 with CDX2, CK7, CK20, chromogranin, and synaptophysin in MKTs of gastric origin (MKTs-stomach), those of colorectal origin (MKTs-colorectum) and those due to appendiceal AdexGCCs (MKT-AdexGCCs) for their sensitivity and specificity to distinguish these tumors...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28914527/locally-induced-adipose-tissue-browning-by-microneedle-patch-for-obesity-treatment
#15
Yuqi Zhang, Qiongming Liu, Jicheng Yu, Shuangjiang Yu, Jinqiang Wang, Li Qiang, Zhen Gu
Obesity is one of the most serious public health problems in the 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current treatments toward obesity including diet, physical exercise, pharmacological therapy, as well as surgeries are always associated with low effectiveness or undesired systematical side effects. In order to enhance treatment efficiency with minimized side effects, we developed a transcutaneous browning agent patch to locally induce adipose tissue transformation...
September 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28914419/social-isolation-during-adolescence-induces-anxiety-behaviors-and-enhances-firing-activity-in-bla-pyramidal-neurons-via-mglur5-upregulation
#16
Song Lin, Xin Li, Yi-Hua Chen, Feng Gao, Hao Chen, Neng-Yuan Hu, Lang Huang, Zheng-Yi Luo, Ji-Hong Liu, Qiang-Long You, Ya-Nan Yin, Ze-Lin Li, Xiao-Wen Li, Zhuo-Jun Du, Jian-Ming Yang, Tian-Ming Gao
Social isolation during the vulnerable period of adolescence contributes to the occurrence of psychiatric disorders and profoundly affects brain development and adult behavior. Although the impact of social isolation during adolescence on anxiety behaviors has been well studied, much less is known about the onset and underlying mechanisms of these behaviors. We observed that following 2 weeks, but not 1 week, of social isolation, adolescent mice exhibited anxiety behaviors. Strikingly, the mGluR5 protein levels in the amygdala increased concomitantly with anxiety behaviors, and both intraperitoneal administration and intra-basolateral amygdala (BLA) infusion of MPEP, a metabotropic glutamate receptor 5 antagonist, normalized anxiety behaviors...
September 15, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28914399/surgery-for-duodenal-gastrointestinal-stromal-tumors-a-single-center-experience
#17
Ping Chen, Tianqiang Song, Xin Wang, Hongyuan Zhou, Ti Zhang, Qiang Wu, Dalu Kong, Yunlong Cui, Huikai Li, Qiang Li
BACKGROUND: The duodenal gastrointestinal stromal tumors (GISTs) are an extremely rare subset of GISTs. The optimal surgical procedure remains not well defined. AIMS: We assessed the surgical approach and long-term outcomes of patients with duodenal GISTs who underwent limited resection (LR) versus pancreaticoduodenectomy (PD). METHODS: From November 2005 to January 2016, 64 consecutive patients with duodenal GISTs in a single center were retrospectively analyzed...
September 15, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28914309/tetragonal-phase-of-cylinders-self-assembled-from-binary-blends-of-ab-diblock-and-a-b-n-star-copolymers
#18
Wenbo Jiang, Yicheng Qiang, Meijiao Liu, Weihua Li, Feng Qiu, An-Chang Shi
The phase behavior of binary blends composed of AB diblock and (A'B)n star copolymers is studied using the polymeric self-consistent field theory, focusing on the formation and stability of the stable tetragonal phase of cylinders. In general, cylindrical domains self-assembled from AB-type block copolymers are packed into a hexagonal array, although a tetragonal array of cylinders could be more favourable for lithography applications in microelectronics. The polymer blends are designed such that there is an attractive interaction between the A and A' blocks, which increases the compatibility between the two copolymers and thus suppresses the macroscopic phase separation of the blends...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28913749/erratum-to-potential-lung-carcinogenicity-induced-by-chronic-exposure-to-pm2-5-in-the-rat
#19
Xiaoli Hu, Qingzhao Li, Shifeng Shao, Qiang Zeng, Chunyang Jiang, Qi Wu, Shoufang Jiang
No abstract text is available yet for this article.
September 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28912447/development-and-validation-of-a-nomogram-for-predicting-survival-in-patients-with-advanced-pancreatic-ductal-adenocarcinoma
#20
Qing-Long Deng, Shu Dong, Lei Wang, Chen-Yue Zhang, Hai-Feng Ying, Zhao-Shen Li, Xiao-Heng Shen, Yuan-Bao Guo, Zhi-Qiang Meng, Jin-Ming Yu, Qi-Wen Chen
This study aimed to develop and validate an effective prognostic nomogram for advanced PDAC patients. We conducted a prospective multicenter cohort study involving 1,526 advanced PDAC patients from three participating hospitals in China between January 1, 2004 and December 31, 2013. Two thirds of the patients were randomly assigned to the training set (n = 1,017), and one third were assigned to the validation set (n = 509). Multivariate cox regression analysis was performed to identify significant prognostic factors for overall survival to develop the nomogram...
September 14, 2017: Scientific Reports
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