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https://www.readbyqxmd.com/read/29145344/the-relationship-of-lung-cancer-with-menstrual-and-reproductive-factors-may-be-influenced-by-passive-smoking-cooking-oil-fumes-and-tea-intake-a-case-control-study-in-chinese-women
#1
Fei He, Jing-Xian Xie, Chun-Lan Liu, Wei-Min Xiong, Qiu-Ping Xu, Zhi-Qiang Liu, Tao Lin, Ren-Dong Xiao, Xu Li, Lin Cai
The aim of this study was to investigate the association of menstrual and reproductive factors with risk of lung cancer in women. Potential etiological clues related to lung cancer in women are identified to inform preventive strategies.Case-control study of 477 newly diagnosed women with lung cancer and 479 age-matched (±2 years) controls. Data on menstrual and reproductive factors and history of oral contraceptive use were obtained on personal interviews using a structured questionnaire. Risk factors were analyzed by unconditional logistic regression analysis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144552/simultaneous-determination-of-tilianin-and-its-metabolites-in-mice-using-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry-and-its-application-to-a-pharmacokinetic-study
#2
Liping Wang, Qingwei Chen, Lijun Zhu, Xuejun Zeng, Qiang Li, Ming Hu, Xinchun Wang, Zhongqiu Liu
Tilianin is an active flavonoid glycoside found in many medical plants. Data are lacking regarding its pharmacokinetics and disposition in vivo. The objective of this study was to develop a sensitive, reliable, and validated ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) method to simultaneously quantify tilianin and its main metabolites and to determine its pharmacokinetics in wild-type and breast cancer resistance protein knockout (Bcrp1-/-) FVB mice. Chromatographic separation was accomplished on a C18 column by utilizing acetonitrile and 0...
November 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29144508/ly6g-neutrophil-derived-mir-223-inhibits-the-nlrp3-inflammasome-in-mitochondrial-damp-induced-acute-lung-injury
#3
Zunyong Feng, Shimei Qi, Yue Zhang, Zhilin Qi, Liang Yan, Jing Zhou, Fang He, Qianqian Li, Yanyan Yang, Qun Chen, Shi Xiao, Qiang Li, Yang Chen, Yao Zhang
MicroRNA (miRNA) mediates RNA interference to regulate a variety of innate immune processes, but how miRNAs coordinate the mechanisms underlying acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in patients with pulmonary inflammatory injury is still unknown. In this study, we demonstrated that miR-223 limits the number of Ly6G+ neutrophils and inhibits the activity of the NLRP3 inflammasome to alleviate ALI induced by mitochondrial damage-associated molecular patterns (DAMPs) (MTDs). miR-223 expression is increased in the lungs of MTD-induced mice or ARDS patients following trauma/transfusion or following the physiological remission of ALI/ARDS...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29144132/large-piezoelectric-effect-in-a-lead-free-molecular-ferroelectric-thin-film
#4
Wei-Qiang Liao, Yuan-Yuan Tang, Peng-Fei Li, Yu-Meng You, Ren-Gen Xiong
Piezoelectric materials have been widely used in various applications, such as high-voltage sources, actuators, sensors, motors, fre-quency standard, vibration reducer, and so on. In the past decades, lead zirconate titanate (PZT) binary ferroelectric ceramics have dominated the commercial piezoelectric market due to their excellent properties near the morphotropic phase boundary (MPB), although they contain more than 60% toxic lead element. Here, we report a lead-free and one-composition molecular ferroelectric trimethylbromomethylammonium tribromomanganese (ΙΙ) (TMBM-MnBr3) with a large piezoelectric coefficient d33 of 112 pC/N along polar axis, comparable with those of typically one-composition piezoceramics such as BaTiO3 along polar axis [001] (~90 pC/N) and much greater than those of most known molecular ferroelectrics (almost below 40 pC/N)...
November 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29144059/association-between-smoking-and-glycemic-control-in-diabetic-patients-results-from-the-reaction-study
#5
Kui Peng, Gang Chen, Chao Liu, Yiming Mu, Zhen Ye, Lixin Shi, Jiajun Zhao, Lulu Chen, Qiang Li, Tao Yang, Li Yan, Qin Wan, Shengli Wu, Guixia Wang, Zuojie Luo, Xulei Tang, Yanan Huo, Zhengnan Gao, Qing Su, Youmin Wang, Guijun Qin, Huacong Deng, Xuefeng Yu, Feixia Shen, Li Chen, Liebin Zhao, Yu Xu, Min Xu, Yuhong Chen, Jieli Lu, Lin Lin, Rui Du, Meng Dai, Mian Li, Tiange Wang, Zhiyun Zhao, Di Zhang, Yufang Bi, Donghui Li, Weiqing Wang, Guang Ning
BACKGROUND: A number of primary studies suggested that active smoking could be independently associated with incident diabetes. However less is known about the impact of active smoking and smoking cessation on glycemic control in patients with diabetes. We aimed to evaluate the associations of active smoking and smoking cessation with glycemic control in diabetic patients. METHODS: This is a cross-sectional study of 10,551 man and 15,297 women with diabetes from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study...
November 16, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29143257/environmental-characteristics-and-changes-of-sediment-pore-water-dissolved-organic-matter-in-four-chinese-lakes
#6
Khan M G Mostofa, Wen Li, Fengchang Wu, Cong-Qiang Liu, Haiqing Liao, Li Zeng, Min Xiao
Sediment pore waters were examined in four Chinese lakes (Bosten, Qinghai, Chenghai and Dianchi) to characterise the sources of dissolved organic matter (DOM) and their microbial changes in the sediment depth profiles. Parallel factor (PARAFAC) modelling on the sample fluorescence spectra confirmed that the pore water DOM was mostly composed of two components with a mixture of both allochthonous and autochthonous fulvic acid-like substances in three lakes, except Lake Dianchi, and protein-like components in Lake Bosten...
November 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29143241/a-highly-selective-naphthalimide-based-chemosensor-naked-eye-colorimetric-and-fluorescent-turn-on-recognition-of-al-3-and-its-application-in-practical-samples-test-paper-and-logic-gate
#7
Na-Na Li, Shuang Zeng, Ming-Qiang Li, Yu-Qing Ma, Xue-Jiao Sun, Zhi-Yong Xing, Jin-Long Li
A novel naphthalimide-based colorimetric and fluorescent turn-on chemosensor for Al(3+) was synthesized and characterized with spectroscopic techniques. In MeOH solution, BPAM showed high selectivity and sensitivity to Al(3+) by a 60-fold fluorescence enhancement and blue-shift absorption with visible color changes attributed to the contribution of chelation enhanced fluorescence (CHEF) and inhibition of intramolecular charge transfer (ICT). A 1:1 BPAM-Al(3+) complex confirmed by job's plot and HRMS with a binding constant of 6...
November 16, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29143001/easily-fabricated-and-lightweight-ppy-pda-agnw-composites-for-excellent-electromagnetic-interference-shielding
#8
Yan Wang, Fu-Qiang Gu, Li-Juan Ni, Kun Liang, Kyle Marcus, Shu-Li Liu, Fan Yang, Jin-Ju Chen, Zhe-Sheng Feng
Conductive polymer composites (CPCs) containing nanoscale conductive fillers have been widely studied for their potential use in various applications. In this paper, polypyrrole (PPy)/polydopamine (PDA)/silver nanowire (AgNW) composites with high electromagnetic interference (EMI) shielding performance, good adhesion ability and light weight are successfully fabricated via a simple in situ polymerization method followed by a mixture process. Benefiting from the intrinsic adhesion properties of PDA, the adhesion ability and mechanical properties of the PPy/PDA/AgNW composites are significantly improved...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29140600/vegetation-cover-another-dominant-factor-in-determining-global-water-resources-in-forested-regions
#9
Xiaohua Wei, Qiang Li, Mingfang Zhang, Krysta Giles-Hansen, Wenfei Liu, Houbao Fan, Yi Wang, Guoyi Zhou, Shilong Piao, Shirong Liu
Forested catchments provide critically important water resources. Due to dramatic global forest change over the past decades, the importance of including forest or vegetation change in the assessment of water resources under climate change has been highly recognized by Intergovernmental Panel on Climate Change (IPCC); however, this importance has not yet been examined quantitatively across the globe. Here, we used four remote sensing-based indices to represent changes in vegetation cover in forest dominated regions, and then applied them to widely-used models: the Fuh model and the Choudhury-Yang model to assess relative contributions of vegetation and climate changes to annual runoff variations from 2000 to 2011 in forested landscape (forest coverage > 30%) across the globe...
November 15, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29138802/in-vitro-investigation-of-the-mechanism-underlying-the-effect-of-ginsenoside-on-the-proliferation-and-differentiation-of-neural-stem-cells-subjected-to-oxygen-glucose-deprivation-reperfusion
#10
Jian Gao, Huajing Bai, Qiang Li, Jian Li, Feng Wan, Mo Tian, Yuanyuan Li, Yilun Song, Jianping Zhang, Yinchu Si
The present study comprised a series of experiments to investigate the mechanism underlying the effect of ginsenoside on the self-renewal, proliferation and differentiation of neural stem cells (NSCs) undergoing oxygen-glucose deprivation/reperfusion (OGD/R) in vitro. The NSCs, which were isolated from the hippocampus of embryonic day 17 embryo rats, were subjected to OGD/R to establish an in vitro model of brain ischemia-reperfusion, following which different doses of ginsenoside were administered to the model...
November 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29137929/enhanced-performance-and-kinetics-of-marine-anammox-bacteria-mab-treating-nitrogen-rich-saline-wastewater-with-mn-ii-and-ni-ii-addition
#11
Jin Li, Li Feng, Zhimin Qiang, Huiyu Dong, Dan Wang
A sequencing batch reactor (SBR) was used to study nitrogen removal performance of marine anammox bacteria (MAB) with Mn(II) and Ni(II) addition. The reactor was operated at 25 ± 0.5 °C with influent pH of 7.5 ± 0.1. Optimal ammonium removal efficiencies (AREs) were 93.95% and 93.18% with 0.05 mM Mn(II) and 0.025 mM Ni(II), respectively. Both Mn(II) and Ni(II) played key roles in treating nitrogen-rich saline wastewater. However, the effect resulting from Ni(II) was far stronger than Mn(II)...
November 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29137431/mitochondrial-dna-depletion-mitochondrial-mutations-and-high-tfam-expression-in-hepatocellular-carcinoma
#12
Lihua Qiao, Guoqing Ru, Zhuochao Mao, Chenghui Wang, Zhipeng Nie, Qiang Li, Yiyi Huang-Yang, Ling Zhu, Xiaoyang Liang, Jialing Yu, Pingping Jiang
We investigated the role of mitochondrial genetic alterations in hepatocellular carcinoma by directly comparing the mitochondrial genomes of 86 matched pairs of HCC and non-tumor liver samples. Substitutions in 637 mtDNA sites were detected, comprising 89.80% transitions and 6.60% transversions. Forty-six somatic variants, including 15 novel mutations, were identified in 40.70% of tumor tissues. Of those, 21 were located in the non-coding region and 25 in the protein-coding region. Twenty-two somatic nonsynonymous changes were identified as putative pathogenic variants, including 4 truncating mutations produced by three frameshifts (MT-ATP6 8628 insC; MT-ND5 13475 T-del, and MT-CYB 14984 insA) and 1 nonsense mutation in MT-CO3 9253 G>A...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137405/necroptosis-regulated-proteins-expression-is-an-early-prognostic-biomarker-in-patient-with-sepsis-a-prospective-observational-study
#13
Bing Wang, Jian Li, Hong-Mei Gao, Ying-Hong Xing, Zhu Lin, Hong-Jie Li, Yong-Qiang Wang
Background and aim: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients. Results: One hundred and twenty-four patients were divided into three groups: 43 patients (34.68%) with sepsis, 39 patients (31.45%) with severe sepsis, and 42 patients (33.87%) with septic shock...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137386/mitochondrial-calcium-uniporter-as-a-target-of-microrna-340-and-promoter-of-metastasis-via-enhancing-the-warburg-effect
#14
Changhui Yu, Yuhao Wang, Jiawen Peng, Qiang Shen, Mimi Chen, Wei Tang, Xiumei Li, Chunqing Cai, Bin Wang, Shaoxi Cai, Xiaojing Meng, Fei Zou
Background: A shift from oxygen phosphorylation to aerobic glycolysis was known as the Warburg effect and a characteristic of cancer cell metabolism facilitating metastasis. Mitochondrial calcium uniporter (MCU), a key ion channel that mediates Ca(2+) uptake into mitochondria, was found to promote cancer progression and metastasis. However, its explicit role in shifting metabolism of breast cancer cells has not been defined. Methods: We evaluated MCU overexpression or knock-down on migration, invasion and glucose metabolismin breast cancer cells...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137375/impact-of-tumor-size-and-cirrhotic-background-for-differentiating-hcc-and-icc-with-ceus-does-it-matter-for-patients-undergoing-hepatectomy
#15
Chen Jin, Xiao-Yun Zhang, Jia-Wu Li, Chuan Li, Wei Peng, Tian-Fu Wen, Yan Luo, Qiang Lu, Xiao-Fei Zhong, Jing-Yi Zhang, Lv-Nan Yan, Jia-Yin Yang
Objectives: The aim of this study was to investigate the role of contrast-enhanced ultrasound (CEUS) in differentiating hepatocellular carcinoma (HCC) vs. intrahepatic cholangiocarcinoma (ICC) and primary liver cancer vs. benign liver lesions for surgical decision making. Methods: Data from 328 patients (296 primary liver cancer patients: 232 HCC and 64 ICC patients and 32 benign hepatic lesion patients) who underwent hepatectomy at our center were retrospectively collected from 2010 to 2015...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137303/the-association-between-ccr5-%C3%AE-32-polymorphism-and-susceptibility-to-breast-cancer
#16
Junlong Li, Yuan Peng, Hui Liu, Qiang Wu
Background: Chemokine C-C motif receptor 5 (CCR5) gene polymorphisms have been proposed to play important roles in tumors. Δ32 polymorphism of this gene might correlate with breast cancer (BC) susceptibility. Nevertheless, inconsistent conclusions have been achieved as yet. We carried out this meta-analysis to draw a more comprehensive and convincing conclusion on this issue. Results: No significant correlation of CCR5 Δ32 polymorphism with individual susceptibility to BC was detected in either total analysis (Δ32 vs...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137275/vinculin-and-filamin-c-are-two-potential-prognostic-biomarkers-and-therapeutic-targets-for-prostate-cancer-cell-migration
#17
Jianzhong Ai, Tao Jin, Lu Yang, Qiang Wei, Yang Yang, Hong Li, Ye Zhu
Prostate cancer (PCa) is one of the most common diseases for male population, and the effective treatment for metastatic castration-resistant PCa is still lacking. To unravel the underlying mechanism of PCa cell migration, we plan to analyze the related crucial proteins and their roles. In our study, we firstly identify the differentially expressed proteins using quantitative proteomics, and confirm their mRNA expression using quantitative polymerase chain reaction (qPCR). The alterations of these proteins at DNA and mRNA levels are obtained from cBioPortal database...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137269/local-blockage-of-self-sustainable-erythropoietin-signaling-suppresses-tumor-progression-in-non-small-cell-lung-cancer
#18
Lei He, Shouzhen Wu, Qiang Hao, Elhadji M Dioum, Kuo Zhang, Cun Zhang, Weina Li, Wei Zhang, Yingqi Zhang, Jiming Zhou, Zhijun Pang, Lijuan Zhao, Xiaowen Ma, Meng Li, Qiuyang Zhang
Functional significance of co-expressed erythropoietin (EPO) and its receptor (EPOR) in non-small cell lung cancer (NSCLC) had been under debate. In this study, co-overexpression of EPO/EPOR was confirmed to be positively associated with poor survival in NSCLC. The serum EPO in 14 of 35 enrolled NSCLC patients were found elevated significantly and decreased to normal level after tumor resection. With primary tumor cell culture and patient-derived tumor xenograft (PDX) mouse model, the EPO secretion from the tumors of these 14 patients was verified...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137011/a-prospective-observational-study-evaluating-the-efficacy-of-prophylactic-internal-iliac-artery-balloon-catheterization-in-the-management-of-placenta-previa-accreta-a-strobe-compliant-article
#19
Yao Fan, Xun Gong, Nan Wang, Ketao Mu, Ling Feng, Fuyuan Qiao, Suhua Chen, Wanjiang Zeng, Haiyi Liu, Yuanyuan Wu, Qiong Zhou, Yuan Tian, Qiang Li, Meitao Yang, Fanfan Li, Mengzhou He, Rajluxmee Beejadhursing, Dongrui Deng
We studied the efficacy of prophylactic internal iliac artery balloon catheterization for managing severe hemorrhage caused by pernicious placenta previa.This prospective observational study was conducted in Tongji Hospital, Wuhan, China. One hundred sixty-three women past 32-week's gestation with placenta previa-accreta were recruited and managed. Women in the balloon group accepted prophylactic internal iliac artery balloon catheterization before scheduled caesarean delivery and controls had a conventional caesarean delivery...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136938/temperature-phased-anaerobic-digestion-of-food-waste-a-comparison-with-single-stage-digestions-based-on-performance-and-energy-balance
#20
Benyi Xiao, Yu Qin, Wenzhe Zhang, Jing Wu, Hong Qiang, Junxin Liu, Yu-You Li
The temperature-phased anaerobic digestion (TPAD) of food waste was studied for the purpose of comparing with single-stage mesophilic and thermophilic anaerobic digestion. The biogas and methane yields in the TPAD during the steady period were 0.759 ± 0.115 L/g added VS and 0.454 ± 0.201 L/g added VS, which were lower than those in the two single-stage anaerobic digestion. The improper sludge retention time may be the reason for the lower biogas and methane production in TPAD. The removal of volatile solids in the TPAD was 78...
October 26, 2017: Bioresource Technology
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