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https://www.readbyqxmd.com/read/28350966/cationic-phosphorus-dendrimer-enhances-photodynamic-activity-of-rose-bengal-against-basal-cell-carcinoma-cell-lines
#1
Monika Dabrzalska, Anna Janaszewska, Maria Zablocka, Serge Mignani, Jean Pierre Majoral, Barbara Klajnert-Maculewicz
In the last couple of decades, photodynamic therapy emerged as a useful tool in the treatment of basal cell carcinoma. However, it still meets limitations due to unfavorable properties of photosensitizers, such as poor solubility or lack of selectivity. Dendrimers - polymers widely studied in biomedical field - may play a role as photosensitizer carriers and improve the efficacy of photodynamic treatment. Here, we describe the evaluation of an electrostatic complex of cationic phosphorus dendrimer and rose bengal in such aspects as singlet oxygen production, cellular uptake and phototoxicity against three basal cell carcinoma cell lines...
March 28, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28350526/exploring-types-of-play-in-an-adapted-robotics-program-for-children-with-disabilities
#2
Sally Lindsay, Ashley Lam
PURPOSE: Play is an important occupation in a child's development. Children with disabilities often have fewer opportunities to engage in meaningful play than typically developing children. The purpose of this study was to explore the types of play (i.e., solitary, parallel and co-operative) within an adapted robotics program for children with disabilities aged 6-8 years. METHOD: This study draws on detailed observations of each of the six robotics workshops and interviews with 53 participants (21 children, 21 parents and 11 programme staff)...
March 28, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28350451/ros-switchable-polymeric-nanoplatform-with-stimuli-responsive-release-for-active-targeted-drug-delivery-to-breast-cancer
#3
Yu Zhang, Qin Guo, Sai An, Yifei Lu, Jianfeng Li, Xi He, Lisha Liu, Yujie Zhang, Tao Sun, Chen Jiang
Tumor microenvironment plays a vital role in the process of tumor development, proliferation, invasion, and metastasis. It is well acknowledged that reduction in pH, reactive oxygen species (ROS), and increased level of glucose transporter 1 (GLUT1) have become featured intracellular and extracellular biochemical markers of cancer owing to oncogenic transformation and abnormal metabolism. To establish a distinctive drug delivery system directed against the tumor microenvironment features, we develop a newly engineered polymeric nanoplatform for efficient doxorubicin (DOX) delivery with reduced systemic toxicity and high antitumor efficiency...
March 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28346925/microbiota-and-necrotizing-enterocolitis
#4
Sanjay Patole
Necrotizing enterocolitis (NEC) is an acquired gastrointestinal inflammatory condition with significant mortality and morbidity in preterm very low birth weight infants. The interplay between toll-like receptors, bacterial endotoxins, developmentally regulated excessive proinflammatory responses of the immature innate immune system, hypoxia, ischemia, reperfusion, free radicals, and the presence of substrates and bacterial endotoxins is thought to play an important role in the pathogenesis of NEC. The association (cause?) of various microbes (bacteria, viruses, and fungi) with NEC has intrigued researchers for many years...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346093/a-label-free-continuous-fluorescence-based-assay-for-monitoring-ornithine-decarboxylase-activity-with-a-synthetic-putrescine-receptor
#5
Mohamed Nilam, Philip Gribbon, Jeanette Reinshagen, Kathrin Cordts, Edzard Schwedhelm, Werner M Nau, Andreas Hennig
Polyamines play an important role in cell growth, differentiation, and cancer development, and the biosynthetic pathway of polyamines is established as a drug target for the treatment of parasitic diseases, neoplasia, and cancer chemoprevention. The key enzyme in polyamine biosynthesis is ornithine decarboxylase (ODC). We report herein an analytical method for the continuous fluorescence monitoring of ODC activity based on the supramolecular receptor cucurbit[6]uril (CB6) and the fluorescent dye trans-4-[4-(dimethylamino)styryl]-1-methylpyridinium iodide (DSMI)...
January 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28345833/efficacy-and-toxicity-of-low-dose-versus-conventional-dose-chemotherapy-for-malignant-tumors-a-meta-analysis-of-6-randomized-controlled-trials
#6
Xianhe Xie, Yupeng Wu, Shuimei Luo, Haitao Yang, Lina Li, Sijing Zhou, Ruifen Shen, Heng Lin
Low-dose chemotherapy has emerged as a new strategy for control of cancer. However, there is a controversy as to whether low-dose chemotherapy is an effective way to manage many human malignancies. To shed light on this controversy, we performed a meta-analysis of relative merits between low-dose and conventional-dose chemotherapy in different carcinomas. Studies published before February 29, 2016 were reviewed for the meta-analysis and selected according to defined criteria. The effect levels of low-dose chemotherapy regarding overall survival (OS), progression-free survival (PFS) and severe adverse events (SAEs) (Grade≥3) were calculated as risk ratios (ORs) or adjusted hazard ratios (HRs)...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345095/a-simple-functional-carbon-nanotube-fiber-for-in-vivo-monitoring-of-no-in-a-rat-brain-following-cerebral-ischemia
#7
Li Liu, Limin Zhang, Zhihui Dai, Yang Tian
Nitric oxide (NO) is key free-radical messenger and neuronal signal which is closely related to many brain diseases. It is a challenge to develop a sensitive and reliable biosensor for in vivo monitoring of NO in the brain. In this research, a simple ratiometric electrochemical biosensor for NO monitoring in rat brain following cerebral ischemia was developed using a carbon nanotube fiber (CNF) modified with hemin, in which the CNF not only served as a platform to assemble the hemin molecule, but greatly facilitated the electron transfer of hemin on to the electrode surface...
March 27, 2017: Analyst
https://www.readbyqxmd.com/read/28345060/genome-reduction-and-microbe-host-interactions-drive-adaptation-of-a-sulfur-oxidizing-bacterium-associated-with-a-cold-seep-sponge
#8
Ren-Mao Tian, Weipeng Zhang, Lin Cai, Yue-Him Wong, Wei Ding, Pei-Yuan Qian
As the most ancient metazoan, sponges have established close relationships with particular microbial symbionts. However, the characteristics and physiology of thioautotrophic symbionts in deep-sea sponges are largely unknown. Using a tailored "differential coverage binning" method on 22-Gb metagenomic sequences, we recovered the nearly complete genome of a sulfur-oxidizing bacterium (SOB) that dominates the microbiota of the cold seep sponge Suberites sp. Phylogenetic analyses suggested that this bacterium (an unclassified gammaproteobacterium termed "Gsub") may represent a new deep-sea SOB group...
March 2017: MSystems
https://www.readbyqxmd.com/read/28344558/role-of-autonomic-nervous-system-and-orexinergic-system-on-adipose-tissue
#9
REVIEW
Giovanni Messina, Anna Valenzano, Fiorenzo Moscatelli, Monica Salerno, Antonio Lonigro, Teresa Esposito, Vincenzo Monda, Gaetano Corso, Antonietta Messina, Andrea Viggiano, Antonio I Triggiani, Sergio Chieffi, Giuseppe Guglielmi, Marcellino Monda, Giuseppe Cibelli
Adipose tissue, defined as white adipose tissue (WAT) and brown adipose tissue (BAT), is a biological caloric reservoir; in response to over-nutrition it expands and, in response to energy deficit, it releases lipids. The WAT primarily stores energy as triglycerides, whereas BAT dissipates chemical energy as heat. In mammals, the BAT is a key site for heat production and an attractive target to promote weight loss. The autonomic nervous system (ANS) exerts a direct control at the cellular and molecular levels in adiposity...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28344405/biochemical-components-of-seminal-plasma-and-their-correlation-to-the-fresh-seminal-characteristics-in-marwari-stallions-and-poitou-jacks
#10
Thirumala Rao Talluri, Gorakh Mal, Sanjay Kumar Ravi
AIM: To investigate various biochemical components of seminal plasma in Marwari stallions and Poitou Jacks and to find out their correlation with that of the seminal characteristics. MATERIALS AND METHODS: In this study, semen was collected from six Marwari stallions and six Poitou jacks aged from 4 to 6 years and with known fertility status. The semen collection from the stallions were collected during the breeding season, i.e., between the months of April and June...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28344217/left-ventricular-twist-was-decreased-in-isolated-left-bundle-branch-block-with-preserved-ejection-fraction
#11
Sabiye Yılmaz, Harun Kılıc, Mustafa Tarık Ağac, Nurgül Keser, Efe Edem, Saadet Demirtaş, Mehmet Bülent Vatan, Ramazan Akdemir, Hüseyin Gündüz
OBJECTIVE: Left ventricular (LV) rotation and twist play an important role in LV contraction and relaxation. Left bundle branch block (LBBB) deteriorates both diastolic and systolic functions. We evaluated the LV twist in patients with LBBB and preserved ejection fraction (EF) (>50%) to determine twist as a potential marker for subtle myocardial dysfunction. METHODS: This observational cross-sectional study included 34 LBBB patients with preserved EF who were free from ischemic and valvular disease (Group 1) and 36 healthy controls (Group 2)...
March 22, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28344104/antimicrobial-medium-and-long-chain-free-fatty-acids-prevent-prfa-dependent-activation-of-virulence-genes-in-listeria-monocytogenes
#12
Eva Maria Sternkopf Lillebæk, Stine Lambert Nielsen, Rikke Scheel Thomasen, Nils J Færgeman, Birgitte H Kallipolitis
The foodborne pathogen Listeria monocytogenes is the causative agent of the invasive disease listeriosis. Infection by L. monocytogenes involves bacterial crossing of the intestinal barrier and intracellular replication in a variety of host cells. The PrfA protein is the master regulator of virulence factors required for bacterial entry, intracellular replication and cell-to-cell spread. PrfA-dependent activation of virulence genes occurs primarily in the blood and during intracellular infection. In contrast, PrfA does not play a significant role in regulation of virulence gene expression in the intestinal environment...
March 23, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28342137/skewed-exposure-to-environmental-antigens-complements-hygiene-hypothesis-in-explaining-the-rise-of-allergy
#13
Wilfried Allaerts, Tse Wen Chang
The Hygiene Hypothesis has been recognized as an important cornerstone to explain the sudden increase in the prevalence of asthma and allergic diseases in modernized culture. The recent epidemic of allergic diseases is in contrast with the gradual implementation of Homo sapiens sapiens to the present-day forms of civilization. This civilization forms a gradual process with cumulative effects on the human immune system, which co-developed with parasitic and commensal Helminths. The clinical manifestation of this epidemic, however, became only visible in the second half of the twentieth century...
March 24, 2017: Acta Biotheoretica
https://www.readbyqxmd.com/read/28340109/mth1-an-8-oxo-2-deoxyguanosine-triphosphatase-and-myh-a-dna-glycosylase-cooperate-to-inhibit-mutations-induced-by-chronic-exposure-to-oxidative-stress-of-ionising-radiation
#14
Sara Shakeri Manesh, Traimate Sangsuwan, Ali Pour Khavari, Asal Fotouhi, S Noushin Emami, Siamak Haghdoost
Our previous results showed that in addition to the immediate interaction of ionising radiation with DNA (direct and indirect effect), low-dose and chronic low-dose rate of irradiation induce endogenous oxidative stress. During oxidative stress, free radicals react with DNA, nucleoside triphosphates (dNTPs), proteins and lipids, and modify their structures. The MYH and MTH1 genes play important roles in preventing mutations induced by 8-hydroxy-guanine, which is an oxidised product of guanine. In this study, we used short-hairpin RNA to permanently knockdown MYH and MTH1 proteins in human lymphoblastoid TK6 cells...
March 16, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28339208/doubly-resonant-photonic-antenna-for-single-infrared-quantum-dot-imaging-at-telecommunication-wavelengths
#15
Zhihua Xie, Yannick Lefier, Miguel Angel Suarez, Mathieu Mivelle, Roland Salut, Jean-Marc Merolla, Thierry Grosjean
Colloidal quantum dots (CQDs) have drawn strong interest in the past for their high prospects in scientific, medical, and industrial applications. However, the full characterization of these quantum emitters is currently restricted to the visible wavelengths, and it remains a key challenge to optically probe single CQDs operating in the infrared spectral domain, which is targeted by a growing number of applications. Here, we report the first experimental detection and imaging at room temperature of single infrared CQDs operating at telecommunication wavelengths...
March 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28338804/duplications-and-positive-selection-drive-the-evolution-of-parasitism-associated-gene-families-in-the-nematode-strongyloides-papillosus
#16
Praveen Baskaran, Tegegn G Jaleta, Adrian Streit, Christian Rödelsperger
Gene duplication is one major mechanism playing a role in the evolution of phenotypic complexity and in the generation of novel traits. By comparing parasitic and nonparasitic nematodes, a recent study found that the evolution of parasitism in Strongyloididae is associated with a large expansion in the Astacin and CAP gene families.To gain novel insights into the developmental processes in the sheep parasite Strongyloides papillosus, we sequenced transcriptomes of different developmental stages and sexes. Overall, we found that the majority of genes are developmentally regulated and have one-to-one orthologs in the diverged S...
March 2, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28338761/influence-of-polynucleosome-preparation-methods-on-sedimentation-velocity-analysis-of-chromatin
#17
Tomoya Kujirai, Shinichi Machida, Akihisa Osakabe, Hitoshi Kurumizaka
Chromatin dynamics and higher order structures play essential roles in genomic DNA functions. Histone variants and histone post-translational modifications are involved in the regulation of chromatin structure and dynamics, cooperatively with DNA methylation and chromatin binding proteins. Therefore, studies of higher-order chromatin conformations have become important to reveal how genomic DNA is regulated during DNA transcription, replication, recombination and repair. The sedimentation velocity analysis by analytical ultracentrifugation has been commonly used to evaluate the higher-order conformation of in vitro reconstituted polynucleosomes, as model chromatin...
December 22, 2016: Journal of Biochemistry
https://www.readbyqxmd.com/read/28338439/stereotactic-radiosurgery-in-the-treatment-of-parasellar-meningiomas-long-term-volumetric-evaluation
#18
Or Cohen-Inbar, Athreya Tata, Shayan Moosa, Cheng-Chia Lee, Jason P Sheehan
OBJECTIVE Parasellar meningiomas tend to invade the suprasellar, cavernous sinus, and petroclival regions, encroaching on adjacent neurovascular structures. As such, they prove difficult to safely and completely resect. Stereotactic radiosurgery (SRS) has played a central role in the treatment of parasellar meningiomas. Evaluation of tumor control rates at this location using simplified single-dimension measurements may prove misleading. The authors report the influence of SRS treatment parameters and the timing and volumetric changes of benign WHO Grade I parasellar meningiomas after SRS on long-term outcome...
March 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28336201/a-facile-method-for-isolation-of-recombinant-human-apolipoprotein-a-i-from-e-coli
#19
Nikita Ikon, Jennifer Shearer, Jianfang Liu, Jesse J Tran, ShiBo Feng, Ayako Kamei, Jennifer A Beckstead, Robert S Kiss, Paul M Weers, Gang Ren, Robert O Ryan
Apolipoprotein (apo) A-I is the major protein component of high-density lipoprotein (HDL) and plays key roles in the Reverse Cholesterol Transport pathway. In the past decade, reconstituted HDL (rHDL) has been employed as a therapeutic agent for treatment of atherosclerosis. The ability of rHDL to promote cholesterol efflux from peripheral cells has been documented to reduce the size of atherosclerotic plaque lesions. However, development of apoA-I rHDL-based therapeutics for human use requires a cost effective process to generate an apoA-I product that meets "Good Manufacturing Practice" standards...
March 20, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28335611/evaluation-of-thioesterases-from-acinetobacter-baylyi-for-production-of-free-fatty-acids
#20
Rahul Ukey, William E Holmes, Rakesh Bajpai, Andrei Y Chistoserdov
Acinetobacter baylyi is one of few Gram-negative bacteria capable of accumulating storage lipids in the form of triacylglycerides and wax esters, which makes it an attractive candidate for production of lipophilic products, including biofuel precursors. Thioesterases play a significant dual role in the triacylglyceride and wax ester biosynthesis by either providing or removing acyl-CoA from this pathway. Therefore, 4 different thioesterase genes were cloned from Acinetobacter baylyi ADP1 and expressed in Escherichia coli to investigate their contribution to free fatty acids (FFAs) accumulation...
March 23, 2017: Canadian Journal of Microbiology
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