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https://www.readbyqxmd.com/read/29454273/mechanosensitive-adhesion-complexes-in-epithelial-architecture-and-cancer-onset
#1
REVIEW
Minerva Bosch-Fortea, Fernando Martín-Belmonte
Mechanical signals from the extracellular space are paramount to coordinate tissue morphogenesis and homeostasis. Although there is a wide variety of cellular mechanisms involved in transducing extracellular forces, recent literature emphasizes the central role of two main adhesion complexes in epithelial mechanosensitive processes: focal adhesions and adherens junctions. These biomechanical sensors can decode physical signals such as matrix stiffness or intercellular tension into a wide range of coordinated cellular responses, which can impact cell differentiation, migration, and proliferation...
February 14, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29454272/dealing-with-the-nucleus-during-cell-migration
#2
REVIEW
Francisco J Calero-Cuenca, Cátia S Janota, Edgar R Gomes
The position of the nucleus within cells is a key event during cell migration. The movement and positioning of the nucleus strongly impacts cell migration. Notably, the last two years largely contributed to emphasise the dynamicity of the nucleus-cytoskeleton interactions that occur during cell migration. Nuclei are under continuous tension from opposing intracellular forces and its tether to the cytoskeleton can be regulated at different levels. Interestingly, it was showed how nuclear positioning is highly related to cell function...
February 14, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29454258/the-role-of-dissociation-in-revictimization-across-the-lifespan-a-32-year-prospective-study
#3
Osnat Zamir, Ohad Szepsenwol, Michelle M Englund, Jeffry A Simpson
Exposure to childhood abuse puts women at risk for revictimization in adult intimate relationships, but knowledge about the mechanism by which it occurs is limited. The present study investigated whether dissociation mediates the effect of exposure to physical or sexual child abuse on intimate partner violence in adulthood. We tested this using prospective data collected from birth to age 32 from 80 female participants in the Minnesota Longitudinal Study of Risk and Adaptation. We found that women who experienced sexual or physical abuse during the first 17...
February 14, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29454239/phenol-separation-from-phenol-laden-saline-wastewater-by-membrane-aromatic-recovery-system-like-membrane-contactor-using-superhydrophobic-organophilic-electrospun-pdms-pmma-membrane
#4
Long-Fei Ren, Mister Adeel, Jun Li, Cong Xu, Zheng Xu, Xiaofan Zhang, Jiahui Shao, Yiliang He
Phenol recovery from phenol-laden saline wastewater plays an important role in the waste reclamation and pollution control. A membrane aromatic recovery system-like membrane contactor (MARS-like membrane contactor) was set up in this study using electrospun polydimethylsiloxane/polymethyl methacrylate (PDMS/PMMA) membrane with 0.0048 m 2 effective area to separate phenol from saline wastewater. Phenol and water contact angles of 0° and 162° were achieved on this membrane surface simultaneously, indicating its potential in the separation of phenol and water-soluble salt...
February 10, 2018: Water Research
https://www.readbyqxmd.com/read/29454209/reconciling-discrepancies-in-the-source-characterization-of-vocs-between-emission-inventories-and-receptor-modeling
#5
Jiamin Ou, Junyu Zheng, Zibing Yuan, Dabo Guan, Zhijiong Huang, Fei Yu, Min Shao, Peter K K Louie
Emission inventory (EI) and receptor model (RM) are two of the three source apportionment (SA) methods recommended by Ministry of Environment of China and used widely to provide independent views on emission source identifications. How to interpret the mixed results they provide, however, were less studied. In this study, a cross-validation study was conducted in one of China's fast-developing and highly populated city cluster- the Pearl River Delta (PRD) region. By utilizing a highly resolved speciated regional EI and a region-wide gridded volatile organic compounds (VOCs) speciation measurement campaign, we elucidated underlying factors for discrepancies between EI and RM and proposed ways for their interpretations with the aim to achieve a scientifically plausible source identification...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454200/effect-of-clonal-integration-on-nitrogen-cycling-in-rhizosphere-of-rhizomatous-clonal-plant-phyllostachys-bissetii-under-heterogeneous-light
#6
Yang Li, Jing-Song Chen, Ge Xue, Yuanying Peng, Hui-Xing Song
Clonal integration plays an important role in clonal plant adapting to heterogeneous habitats. It was postulated that clonal integration could exhibit positive effects on nitrogen cycling in the rhizosphere of clonal plant subjected to heterogeneous light conditions. An in-situ experiment was conducted using clonal fragments of Phyllostachys bissetii with two successive ramets. Shading treatments were applied to offspring or mother ramets, respectively, whereas counterparts were treated to full sunlight. Rhizomes between two successive ramets were either severed or connected...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454194/diagnostic-and-treatment-services-for-patients-with-psychogenic-nonepileptic-seizures-pnes-a-survey-of-health-professionals-in-urban-china
#7
Xin Tong, Dongmei An, Markus Reuber, Qin Zhang, Dong Zhou
PURPOSE: This study is intended to provide an overview of diagnostic and treatment services for patients with psychogenic nonepileptic seizures (PNES) across China. METHODS: Using a questionnaire devised by the PNES Task Force of Neuropsychiatry Commission of the International League Against Epilepsy (ILAE), we conducted a survey among Chinese health professionals at the Sixth Advanced International Course: Clinical Epileptology. Descriptive analyses were performed...
January 31, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29454152/the-influence-of-biogenic-amines-on-th17-mediated-immune-response-in-multiple-sclerosis
#8
REVIEW
Mikhail Melnikov, Vladimir Rogovskii, Alexey Boyko, Mikhail Pashenkov
Biogenic amines are direct mediators of interactions between immune and nervous systems implicated in the pathogenesis of multiple sclerosis (MS). Recently, great attention has been drawn to studying the effects of biogenic amines on Th17-cells, which play one of the central roles in the development of inflammatory lesions in MS. Results of these studies suggest that, depending on the activation of particular receptors, biogenic amines can both enhance and inhibit Th17-cell functions. Based on these data, targeting biogenic amines and their receptors could be explored as a new kind of additional disease-modifying treatment of MS...
February 12, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29454137/mechanisms-and-management-of-refractory-ventricular-arrhythmias-in-the-age-of-autonomic-modulation
#9
Jason S Bradfield, Olujimi A Ajijola, Marmar Vaseghi, Kalyanam Shivkumar
Ventricular arrhythmias are responsible for hundreds of thousands of deaths every year. Catheter ablation of ventricular tachycardia (VT) is an essential component of the management of these life-threatening arrhythmias. However, in many patients, despite medical and interventional therapy, VT recurs. Further, some VT substrates (mid-myocardial, left ventricular summit, intra-septal) are not easily targeted, due to limitations of currently available technology. In certain clinical settings, ventricular fibrillation (VF) episodes that have premature ventricular contraction (PVC) triggers can also be targeted with catheter ablation...
February 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29454107/archetype-modeling-methodology
#10
David Moner, José Alberto Maldonado, Montserrat Robles
Clinical Information Models (CIMs) expressed as archetypes play an essential role in the design and development of current Electronic Health Record (EHR) information structures. Although there exist many experiences about using archetypes in the literature, a comprehensive and formal methodology for archetype modeling does not exist. Having a modeling methodology is essential to develop quality archetypes, in order to guide the development of EHR systems and to allow the semantic interoperability of health data...
February 14, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29454093/silencing-circular-rna-hsa_circ_0000977-suppresses-pancreatic-ductal-adenocarcinoma-progression-by-stimulating-mir-874-3p-and-inhibiting-plk1-expression
#11
Wen-Jie Huang, Yun-Chao Wang, Song-Song Liu, Jia-Li Yang, Shi-Xiang Guo, Li-Jiang Wang, Huai-Zhi Wang, Ying-Fang Fan
Circular RNAs (CircRNAs) are a novel type of endogenous noncoding RNAs that regulate target gene expression by interacting with microRNA (miRNA). Emerging evidence shows that dysregulation of circRNAs plays important roles in biological and pathological processes, including cancer development and progression. The functional role of circRNA in PDAC (pancreatic ductal adenocarcinoma) remains to be investigated. In this study, high throughput microarray assay revealed that hsa_circ_0000977 was aberrantly up-regulated in pancreatic cancer tissues; this was also validated by qRT-PCR...
February 14, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29454089/genome-wide-gene-expression-analysis-of-45-days-pregnant-fetal-cotyledons-vis-a-vis-non-pregnant-caruncles-in-buffalo-bubalus-bubalis
#12
Masoud Lotfan, Syed Azmal Ali, Munnalal Yadav, Suman Chuadhary, Manoj Kumar Jena, Sudarshan Kumar, Ashok Kumar Mohanty
The crosstalk between fetus and mother starts with the onset of placental attachment to the uterus. The cotyledons and caruncles are the two anatomically distinct structures that play a crucial role in this physiological communication. Using Agilent Gene Chip Genome microarray, we measured the expression profile of pregnancy cotyledons in comparison to caruncular reminiscence of the uteri in non-pregnant buffalo (Bubalus bubalis) for the detection of the early post-pregnancy rapid changes in cellular expression of mRNA transcripts...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29454088/hsf4-transcriptional-regulates-hmox-1-expression-in-hlecs
#13
Shengjie Liao, Zhen Qu, Linqiang Li, Benwen Zhou, Meng Gao, Mi Huang, Duanzhuo Li
The major causes for cataract formation are free radicals, which are neutralized by the endogenous antioxidants. However, how the human lens clean these harmful free radicals is still unclear. Transcriptional factor heat shock factor 4 (HSF4) is a cataract-causing gene and plays important roles during lens development. Here we show that HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE element in HMOX-1 promoter to mediate its mRNA transcription and protein accumulation...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29454065/impact-of-food-additives-on-the-gut-brain-axis
#14
Mary K Holder, Benoit Chassaing
The mammalian intestinal tract is heavily colonized with a complex community of micro-organisms, present at a very high density, and containing an estimated amount of 10 14 bacteria. The microbiota generally benefits the host, as it plays a central role in maturing the immune system, protecting against infection by entero-pathogens such as Clostridium difficile, and favoring nutrient digestion/energy extraction in our intestine. An altered microbiota, however, can become detrimental and lead to inflammation, metabolic disorders, and even altered behavior/neuroinflammation...
February 14, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29454056/biophysical-and-immunological-characterization-of-2-drib-modified-hsa-and-its-implications-in-diabetes-mellitus
#15
Ishrat Jahan Saifi, Km Neelofar, M R Ajmal, Sheelu Shafiq Siddiqi
Glycoxidation of protein may lead to develop diabetes. In the present study, different concentrations of 2-deoxy d-ribose (2-dRib) were used to modify human serum albumin (HSA). Nitro Blue Tetrazolium (NBT) assay results showed that yield of the fructosamine content was directly proportional to the concentration of 2-dRib. UV and fluorescence spectroscopy results showed an increment in hyperchromicity and decrease in fluorescence intensity of 2-dRib modified HSA as compared to native HSA. Further secondary structural changes were confirmed by UV-circular dichroism (UV-CD) and Fourier transform infrared spectroscopy (FT-IR)...
February 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454035/high-and-low-doses-of-cocaine-intake-are-differentially-regulated-by-dopamine-d2-receptors-in-the-ventral-tegmental-area-and-the-nucleus-accumbens
#16
R Chen, S McIntosh, S E Hemby, H Sun, T Sexton, Thomas Martin, S R Childers
Dopamine D2 receptors (D2Rs) in the ventral tegmental area (VTA) and the nucleus accumbens (NAc) are associated with vulnerability to addiction; however, whether D2Rs in these two brain regions play differential roles in regulation of drug intake is unknown. Here, we compared the effect of decreased mRNA level of Drd2 in each region on cocaine self-administration in a dose-response function. Drd2 mRNA levels in rat VTA or NAc were knocked down by bilateral microinjection of lentivirus coding shRNAs against rat Drd2...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29453993/the-tegumental-allergen-like-proteins-of-schistosoma-mansoni-a-biochemical-study-of-smtal4-tal13
#17
Jack Carson, Charlotte M Thomas, Aaron McGinty, Gustavo Takata, David J Timson
Schistosoma mansoni, like other trematodes, expresses a number of unusual calcium binding proteins which consist of an EF-hand domain joined to a dynein light chain-like (DLC-like) domain by a flexible linker. These proteins have been implicated in host immune responses and drug binding. Three members of this protein family from S. mansoni (SmTAL1, SmTAL2 and SmTAL3) have been well characterised biochemically. Here we characterise the remaining family members from this species (SmTAL4-13). All of these proteins form homodimers and all except SmTAL5 bind to calcium and manganese ions...
February 14, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29453990/atp-activated-p2x7-receptor-in-the-pathophysiology-of-mood-disorders-and-as-an-emerging-target-for-the-development-of-novel-antidepressant-therapeutics
#18
REVIEW
Linyu Wei, Sharifah A Syed Mortadza, Jing Yan, Libin Zhang, Lu Wang, Yaling Yin, Chaokun Li, Sylvie Chalon, Patrick Emond, Catherine Belzung, Dongliang Li, Chengbiao Lu, Sebastien Roger, Lin-Hua Jiang
Mood disorders are a group of psychiatric conditions that represent leading global disease burdens. Increasing evidence from clinical and preclinical studies supports that innate immune system dysfunction plays an important part in the pathophysiology of mood disorders. P2X7 receptor, belonging to the ligand-gated ion channel P2X subfamily of purinergic P2 receptors for extracellular ATP, is highly expressed in immune cells including microglia in the central nervous system (CNS) and has a vital role in mediating innate immune response...
February 14, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29453986/sterol-o-acyltransferase-1-deficiency-improves-defective-insulin-signaling-in-the-brains-of-mice-fed-a-high-fat-diet
#19
Ning Xu, Hao Meng, Tian-Yi Liu, Ying-Li Feng, Yuan Qi, Dong-Huan Zhang, Hong-Lei Wang
Insulin resistance induced by a high-fat diet (HFD) is related to metabolic diseases, and sterol O-acyltransferase 1 (SOAT1) is a key enzyme for the biosynthesis of cholesteryl ester. In the present study, wild-type (WT) mice and SOAT1-knockout (KO) mice with a C57BL6 background fed a HFD were used to explore the role of SOAT1 in the hypothalamus. The results show that the WT mice exhibited a significant increase in body weight as well as hepatic histologic changes; they also had a lower glucose and insulin tolerance than the WT mice fed a normal diet...
February 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29453985/zika-virus-infected-primary-microglia-impairs-npcs-proliferation-and-differentiation
#20
Jin Wang, Jing Liu, Rui Zhou, Xin Ding, Qipeng Zhang, Chenyu Zhang, Liang Li
Zika virus (ZIKV) can lead to severe birth defects especially microcephaly in newborns by infecting human neural progenitors and impairing brain development. However, as the resident immune cells in the brain, the role of microglia in the ZIKV pathology is not clearly defined. To understand the interplay between immune response and neural cells, we investigate the interaction between microglia and NPCs during ZIKV infection. Our results demonstrate that primary microglia infected with ZIKV induces an inflammatory response similar to that in human, producing high level of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 1β (IL-1β) and inducible nitric oxide synthase (iNOS)...
February 14, 2018: Biochemical and Biophysical Research Communications
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