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https://www.readbyqxmd.com/read/29677687/endothelial-dysfunction-as-a-long-term-effect-of-late-onset-hypertensive-pregnancy-disorders-high-bmi-is-key
#1
L J Alma, C J M De Groot, R X De Menezes, W Hermes, P L Hordijk, I Kovačević
OBJECTIVE: Hypertensive disorders during pregnancy increase cardiovascular risk later in life by 2 to 9-fold. Endothelial activation is one of the underlying mechanisms of cardiovascular risk. Therefore, we decided to investigate endothelial activation in primiparous women, 2.5 years after a hypertensive pregnancy disorder. STUDY DESIGN: Plasma samples were taken from women 2.5 years after gestational hypertension (GH) or late onset preeclampsia (cases) and from women 2...
April 12, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29677640/18%C3%AE-glycyrrhetinic-acid-mitigates-radiation-induced-skin-damage-via-nadph-oxidase-ros-p38mapk-and-nf-%C3%AE%C2%BAb-pathways
#2
Li Su, Zeng Wang, Fei Huang, Ruilong Lan, Xiuying Chen, Deping Han, Lurong Zhang, Weijian Zhang, Jinsheng Hong
Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18β-GA treatment decreased the production of IL-1β, IL-6, PGE2 and decreased p38MAPK phosphorylation, DNA-binding activity of AP-1, and NF-κB activation in irradiated RAW264.7 macrophages. Additionally, 18β-GA suppressed NF-κB activation by inhibiting NF-κB/p65 and IκB-α phosphorylation and alleviated ROS overproduction in irradiated RAW264...
April 13, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29677632/heat-shock-induced-cathepsin-b-activity-during-ivf-and-culture-compromises-the-developmental-competence-of-bovine-embryos
#3
Ken-Ichi Yamanaka, Hafiza Khatun, Junki Egashira, Ahmed Zaky Balboula, Hideki Tatemoto, Miki Sakatani, Naoki Takenouchi, Yasuhiko Wada, Masashi Takahashi
Heat stress can cause significant reproductive dysfunction in mammals and previous studies report that expression and activity of cathepsin B (CTSB), a lysosomal cysteine protease, is negatively correlated with the developmental competence of bovine oocytes and embryos. However, the relationship between heat shock (HS) and CTSB remains largely unknown. Here, we investigated the effects of HS during IVF and early embryonic stages of IVC on CTSB activity and developmental competence in bovine embryos. HS (40 °C for 6 h during IVF and 20 h during IVC) caused a significant increase in CTSB activity irrespective of the developmental stage or duration of HS...
April 6, 2018: Theriogenology
https://www.readbyqxmd.com/read/29677620/hippocampal-fxr-plays-a-role-in-the-pathogenesis-of-depression-a-preliminary-study-based-on-lentiviral-gene-modulation
#4
Wei-Guan Chen, Jia-Xuan Zheng, Xi Xu, Yu-Ming Hu, Yu-Min Ma
As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious and worldwide neuropsychiatric disease. It was found that chronic unpredictable mild stress (CUMS) fully enhanced the protein and mRNA expressions of FXR in hippocampus, but not medial prefrontal cortex (mPFC)...
April 10, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29677618/altered-serum-levels-of-vascular-endothelial-growth-factor-in-first-episode-drug-na%C3%A3-ve-and-chronic-medicated-schizophrenia
#5
Fei Ye, Qiongqiong Zhan, Wenhuan Xiao, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
There is much evidence of a relationship between alterations in the brain's regional cellular energy metabolism and blood flow in schizophrenic. Vascular endothelial growth factor (VEGF) plays a role in the pathogenesis of neuropsychiatric illnesses. So, we compared serum VEGF levels in drug-naïve first-episode psychotic (FEP) and chronically medicated schizophrenic to examine if a correlation existed between VEGF and psychopathological symptoms. The serum VEGF levels were assessed in 46 FEP patients, 47 chronic medicated patients and 50 healthy controls...
April 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29677617/high-annealing-temperature-induced-rapid-grain-coarsening-for-efficient-perovskite-solar-cells
#6
Xiaobing Cao, Lili Zhi, Yi Jia, Yahui Li, Xian Cui, Ke Zhao, Lijie Ci, Kongxian Ding, Jinquan Wei
Thermal annealing plays multiple roles in fabricating high quality perovskite films. Generally, it might result in large perovskite grains by elevating annealing temperature, but might also lead to decomposition of perovskite. Here, we study the effects of annealing temperature on the coarsening of perovskite grains in a temperature range from 100 to 250 °C, and find that the coarsening rate of the perovskite grain increase significantly with the annealing temperature. Compared with the perovskite films annealed at 100 °C, high quality perovskite films with large columnar grains are obtained by annealing perovskite precursor films at 250 °C for only 10 s...
April 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29677599/bactericidal-activity-and-mechanisms-of-biobr-agbr-under-both-dark-and-visible-light-irradiation-conditions
#7
Ting Feng, Jialiang Liang, Zhiyao Ma, Mian Li, Meiping Tong
BiOBr-AgBr hybrid photocatalysts were synthesized via a facile precipitation and in-situ ion exchange method at room temperature. The as-synthesized photocatalysts were well characterized with different techniques. The disinfection activities of BiOBr-AgBr towards model bacterial strain Gram-negative Escherichia coli (E. coli) were tested under both dark and visible light irradiation conditions. 1 × 107 CFU/mL of E. coli cells could be completely inactivated by BiOBr-AgBr with the optimal silver amount (BiOBr-0...
April 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29677593/lucky-or-clever-from-expectations-to-responsibility-judgments
#8
Tobias Gerstenberg, Tomer D Ullman, Jonas Nagel, Max Kleiman-Weiner, David A Lagnado, Joshua B Tenenbaum
How do people hold others responsible for the consequences of their actions? We propose a computational model that attributes responsibility as a function of what the observed action reveals about the person, and the causal role that the person's action played in bringing about the outcome. The model first infers what type of person someone is from having observed their action. It then compares a prior expectation of how a person would behave with a posterior expectation after having observed the person's action...
April 17, 2018: Cognition
https://www.readbyqxmd.com/read/29677583/grandparents-and-children-s-stunting-in-sub-saharan-africa
#9
Sandor Schrijner, Jeroen Smits
Globally an estimated 159 million children under 5 years of age are being too short for one's age (stunted). More than one third of these children is living in Africa. Given the substantial number of sub-Saharan African (SSA) children living in households with co-residing grandparents and the negative effects of stunting on productivity and economic growth, gaining insight into the role grandparents play for children's stunting, has become increasingly important. By applying multilevel logistic regression analysis on a database with information on 344,748 children aged 6-60 months living in 31 SSA countries, the strength of the relationship between grandparental co-residence and children's stunting is examined...
March 26, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29677568/validation-of-the-cps-eg-and-neo-bioscore-staging-systems-after-preoperative-systemic-therapy-for-breast-cancer-in-a-single-center-in-china
#10
Ling Xu, Xuening Duan, Bin Zhou, Yinhua Liu, Jingming Ye, Zhaorui Liu, Chao Ma, Hong Zhang, Shuang Zhang, Lanbo Zhang, Jianxin Zhao, Yuanjia Cheng
BACKGROUND: Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in determining treatment in breast cancer patients. Many researchers have sought to develop a system to quantitate residual tumor and its correlation with prognosis after PST. This retrospective study validated the CPS + EG staging system and Neo-Bioscore in a single center in China. METHODS: Data from patients with non-metastatic primary breast cancer who were treated with PST and surgery from Jan...
April 17, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29677558/robust-generalized-mittag-leffler-synchronization-of-fractional-order-neural-networks-with-discontinuous-activation-and-impulses
#11
A Pratap, R Raja, C Sowmiya, O Bagdasar, Jinde Cao, G Rajchakit
Fractional order system is playing an increasingly important role in terms of both theory and applications. In this paper we investigate the global existence of Filippov solutions and the robust generalized Mittag-Leffler synchronization of fractional order neural networks with discontinuous activation and impulses. By means of growth conditions, differential inclusions and generalized Gronwall inequality, a sufficient condition for the existence of Filippov solution is obtained. Then, sufficient criteria are given for the robust generalized Mittag-Leffler synchronization between discontinuous activation function of impulsive fractional order neural network systems with (or without) parameter uncertainties, via a delayed feedback controller and M-Matrix theory...
April 4, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29677555/matrix-architecture-plays-a-pivotal-role-in-3d-osteoblast-migration-the-effect-of-interstitial-fluid-flow
#12
Cristina Del Amo, Vanesa Olivares, Mar Cóndor, Alejandro Blanco, Jorge Santolaria, Jesús Asín, Carlos Borau, José Manuel García-Aznar
Osteoblast migration is a crucial process in bone regeneration, which is strongly regulated by interstitial fluid flow. However, the exact role that such flow exerts on osteoblast migration is still unclear. To deepen the understanding of this phenomenon, we cultured human osteoblasts on 3D microfluidic devices under different fluid flow regimes. Our results show that a slow fluid flow rate by itself is not able to alter the 3D migratory patterns of osteoblasts in collagen-based gels but that at higher fluid flow rates (increased flow velocity) may indirectly influence cell movement by altering the collagen microstructure...
April 10, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29677551/growth-detection-and-virulence-of-listeria-monocytogenes-in-the-presence-of-other-microorganisms-microbial-interactions-from-species-to-strain-level
#13
REVIEW
Evangelia A Zilelidou, Panagiotis N Skandamis
Like with all food microorganisms, many basic aspects of L. monocytogenes life are likely to be influenced by its interactions with bacteria living in close proximity. This pathogenic bacterium is a major concern both for the food industry and health organizations since it is ubiquitous and able to withstand harsh environmental conditions. Due to the ubiquity of Listeria monocytogenes, various strains may contaminate foods at different stages of the supply chain. Consequently, simultaneous exposure of consumers to multiple strains is also possible...
April 12, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29677542/innovative-perception-on-using-tiron-to-modulate-the-hepatotoxicity-induced-by-titanium-dioxide-nanoparticles-in-male-rats
#14
Ashraf Morgan, Marwa A Ibrahim, Mona K Galal, Hanan A Ogaly, Reham M Abd-Elsalam
The extensive application of titanium dioxide nanoparticles (TiO2 NPs) in the food industry arouses a debate regarding the probable risk associated with their use. Several recent studies reported that most nanoparticles (NPs) have adverse actions on the liver. The objective of this study is to examine whether Tiron plays a modulatory role against apoptotic damage induced by TiO2 NPs in rat livers. Forty rats were randomly divided into 4 groups; a control group received phosphate-buffered saline, an intoxicated group received 100 mg/kg/day of TiO2 NPs for 60 days, a treated group received 470 mg/kg/day of Tiron for the last 14 days after TiO2 NPs administration, and a Tiron group received Tiron only as previously mentioned...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677539/fibromyalgia-and-nutrition-therapeutic-possibilities
#15
REVIEW
Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Jan Aaseth
Fibromyalgia (FM) is a complex chronic condition of unknown etiology, characterized by deep and widespread pain, sleep problems, cognitive impairment, fatigue, and other well-known functional symptoms. Recently, it has been proposed that an imbalance of nutritive components, including essential metal ions and vitamins, might play a critical role in the development of FM. Muscle pain has been associated with deficiencies in amino acids, magnesium, selenium, vitamins B and D, as well as with the harmful effects of heavy metals, such as mercury, cadmium, and lead...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677519/suspended-graphene-oxide-nanosheets-maintain-the-self-renewal-of-mouse-embryonic-stem-cells-via-down-regulating-the-expression-of-vinculin
#16
Guoxin Jing, Zhaojie Wang, Xizhen Zhuang, Xiaolie He, Huijun Wu, Qingxiu Wang, Liming Cheng, Zhongmin Liu, Shilong Wang, Rongrong Zhu
Graphene oxide (GO), with good hydrophilicity and biocompatibility, is widely explored as a carrier for various factors in the field of stem cell differentiation. However, its function of sustaining the stemness of mouse embryonic stem cells (mESCs) and the underlying mechanisms of this process remains undiscovered. Herein, we explored the biofunction of GO on mESCs and revealed the involved signaling pathways and key gene. The alkaline phosphatase activity detection, pluripotency genes quantification and the teratomas formation in vivo confirmed that GO nanosheets could sustain the self-renewal ability of mESCs instead of influencing its pluripotency...
April 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29677517/gpr68-senses-flow-and-is-essential-for-vascular-physiology
#17
Jie Xu, Jayanti Mathur, Emilie Vessières, Scott Hammack, Keiko Nonomura, Julie Favre, Linda Grimaud, Matt Petrus, Allain Francisco, Jingyuan Li, Van Lee, Fu-Li Xiang, James K Mainquist, Stuart M Cahalan, Anthony P Orth, John R Walker, Shang Ma, Viktor Lukacs, Laura Bordone, Michael Bandell, Bryan Laffitte, Yan Xu, Shu Chien, Daniel Henrion, Ardem Patapoutian
Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark of endothelial dysfunction and a precursor to a wide array of vascular diseases, such as hypertension and atherosclerosis. Yet the molecules responsible for sensing flow (shear stress) within endothelial cells remain largely unknown. We designed a 384-well screening system that applies shear stress on cultured cells...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677511/an-integrated-genome-wide-crispra-approach-to-functionalize-lncrnas-in-drug-resistance
#18
Assaf C Bester, Jonathan D Lee, Alejandro Chavez, Yu-Ru Lee, Daphna Nachmani, Suhani Vora, Joshua Victor, Martin Sauvageau, Emanuele Monteleone, John L Rinn, Paolo Provero, George M Church, John G Clohessy, Pier Paolo Pandolfi
Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia (AML), we developed a comprehensive and integrated genome-wide platform based on a dual protein-coding and non-coding integrated CRISPRa screening (DICaS). Putative resistance genes were initially identified using pharmacogenetic data from 760 human pan-cancer cell lines. Subsequently, genome scale functional characterization of both coding and long non-coding RNA (lncRNA) genes by CRISPR activation was performed...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677509/beyond-host-defense-emerging-functions-of-the-immune-system-in-regulating-complex-tissue-physiology
#19
REVIEW
Lucille C Rankin, David Artis
The essential roles played by the immune system in the discrimination between self- versus non/altered-self and its integral role in promoting host defense against invading microbes and tumors have been extensively studied for many years. In these contexts, significant advances have been made in defining the molecular and cellular networks that orchestrate cell-cell communication to mediate host defense and pathogen expulsion. Notably, recent studies indicate that in addition to these classical immune functions, cells of the innate and adaptive immune system also sense complex tissue- and environment-derived signals, including those from the nervous system and the diet...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677483/design-synthesis-and-biological-evaluation-of-pyrimidine-based-derivatives-as-vegfr-2-tyrosine-kinase-inhibitors
#20
Wuji Sun, Shengquan Hu, Shubiao Fang, Hong Yan
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has already become an attractive approach for cancer therapy. In this study, a novel pyrimidine-based derivative 7j was designed as lead compound, and three series of potent VEGFR-2 inhibitors were synthesized and biologically evaluated against A549 and HepG2 cell lines. Compounds 7d, 9s and 13n exhibited superior inhibitory activities against A549 cell with IC50 ranged from 9...
April 13, 2018: Bioorganic Chemistry
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