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https://www.readbyqxmd.com/read/27895045/cardiorespiratory-fitness-and-highly-sensitive-cardiac-troponin-levels-in-a-preventive-medicine-cohort
#1
Laura F DeFina, Benjamin L Willis, Nina B Radford, Robert H Christenson, Christopher R deFilippi, James A de Lemos
BACKGROUND: Cardiorespiratory fitness (CRF) and highly sensitive cardiac troponin T (hs-cTnT) are associated with risk of all-cause and cardiovascular mortality as well as incident heart failure. A link of low CRF to subclinical cardiac injury may explain this association. We hypothesized that CRF would be inversely associated with hs-cTnT measured in healthy adults over age 50. METHODS AND RESULTS: We evaluated 2498 participants (24.7% female, mean age 58.7 years) from the Cooper Center Longitudinal Study between August 2008 and January 2012...
November 28, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27865153/efficient-multi-scale-3d-cnn-with-fully-connected-crf-for-accurate-brain-lesion-segmentation
#2
Konstantinos Kamnitsas, Christian Ledig, Virginia F J Newcombe, Joanna P Simpson, Andrew D Kane, David K Menon, Daniel Rueckert, Ben Glocker
We propose a dual pathway, 11-layers deep, three-dimensional Convolutional Neural Network for the challenging task of brain lesion segmentation. The devised architecture is the result of an in-depth analysis of the limitations of current networks proposed for similar applications. To overcome the computational burden of processing 3D medical scans, we have devised an efficient and effective dense training scheme which joins the processing of adjacent image patches into one pass through the network while automatically adapting to the inherent class imbalance present in the data...
October 29, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27753997/ed-07-2-to-lift-walk-or-run-what-is-the-optimal-mode-of-exercise-to-reduce-hypertension-and-prevent-cardiovascular-disease
#3
Peter Kokkinos
A plethora of evidence exists supporting that structured aerobic exercise or activities that increase cardiorespiratory fitness (CRF) lower resting blood pressure (BP) in patients with hypertension (HTN). Relatively few studies have assessed the effects of anaerobic or resistance exercise on BP. Thus, its role in managing HTN is not defined. Also, possible risks related with exercise in hypertensive patients have not been adequately addressed.In addition to lowering BP, CRF attenuates the incidence of HTN. A substantial part of the age-related progression to HTN is not an inevitable outcome of aging as once thought, but a consequence of lifestyle characterized by high-fat/salt diets and physical inactivity...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642908/ed-07-2-to-lift-walk-or-run-what-is-the-optimal-mode-of-exercise-to-reduce-hypertension-and-prevent-cardiovascular-disease
#4
Peter Kokkinos
A plethora of evidence exists supporting that structured aerobic exercise or activities that increase cardiorespiratory fitness (CRF) lower resting blood pressure (BP) in patients with hypertension (HTN). Relatively few studies have assessed the effects of anaerobic or resistance exercise on BP. Thus, its role in managing HTN is not defined. Also, possible risks related with exercise in hypertensive patients have not been adequately addressed.In addition to lowering BP, CRF attenuates the incidence of HTN. A substantial part of the age-related progression to HTN is not an inevitable outcome of aging as once thought, but a consequence of lifestyle characterized by high-fat/salt diets and physical inactivity...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27577396/transcription-of-case-report-forms-from-unstructured-referral-letters-a-semantic-text-analytics-approach
#5
Syed Sibte Raza Abidi, Abhinav Kumar Singh, Sean Christie
In this paper we present a framework for the semi-automatic extraction of medical entities from referral letters and use them to transcribe a case report form. Our framework offers the functionality to: (a) extract the medical entity from the unstructured referral letters, (b) classify them according to their semantic type, and (c) transcribe a case report form based on the extracted information from the referral letter. We take a semantic text analytics approach where SNOMED-CT ontology is used to both classify referral concepts and to establish semantic similarities between referral concepts and CRF elements...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27468477/-effect-of-fushengong-decoction-on-the-expression-of-nephrin-mrna-in-kidney-of-rats-with-chronic-renal-failure
#6
Ling Wang, Xue-kuan Huang, Lei Wan, Yu Yang
OBJECTIVE: To investigate the effect of Fushengong Decoction on the expression of nephrin mRNA in renal tissue of rats with chronic renal failure (CRF). METHODS: Fifty five male SD rats were randomly divided into five groups: control group, CRF model group, and low, medium and high Fushengong Decoction dose groups. Rats in control group were fed with standard chow, while the other four groups were fed with adenine to make CRF. The rats in control group received intra-gastric normal saline (NS) of 20 mL/(kg · d) for 30 d, while those in low, medium and high Fushengong Decoction dose groups received Fushengong Decoction at the dose of 4 g/kg, 8 g/kg and 16 g/kg respectively, once a day for 30 d...
May 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/27389132/magnitude-of-rib-fracture-displacement-predicts-opioid-requirements
#7
Nikolay Bugaev, Janis L Breeze, Majid Alhazmi, Hassan S Anbari, Sandra S Arabian, Sharon Holewinski, Reuven Rabinovici
INTRODUCTION: It is unknown whether the magnitude of rib fracture (RF) displacement predicts pain medication requirements in blunt chest trauma patients. METHODS: Adult blunt RF patients undergoing computed tomography (CT) of the chest admitted to an urban Level 1 trauma center (2007-2012) were retrospectively reviewed. Pain management in those with displaced RF (DRF), nondisplaced RF (NDRF), or combined DRF and NDRF (CRF) was compared by univariate analysis. Linear regression models were developed to determine whether total opioid requirements [expressed as log morphine equianalgesic dose (MED)] could be predicted by the magnitude of RF displacement (expressed as the sum of the Euclidean distance of all displaced RF) or number of RF, after adjusting for patient and injury characteristics...
October 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27210720/bone-marrow-mesenchymal-stromal-cells-ameliorate-angiogenesis-and-renal-damage-via-promoting-pi3k-akt-signaling-pathway-activation-in-vivo
#8
Xiaojing Jia, Jinbing Pan, Xiuhua Li, Na Li, Yan Han, Xing Feng, Jianjun Cui
OBJECTIVE: The objective of this study was to investigate the effects of the intravenous transplantation of bone marrow mesenchymal stromal cells (BM-MSCs) on the repair of glomerular endothelia and angiogenesis in rats with chronic renal failure (CRF). Furthermore, the mechanism of BM-MSCs promoting angiogenesis was explored by detection of Akt and P-Akt protein expression in rat kidney tissue. MATERIAL AND METHODS: A rat model with CRF was established by adenine...
July 2016: Cytotherapy
https://www.readbyqxmd.com/read/26903149/an-integrated-lipidomics-and-metabolomics-reveal-nephroprotective-effect-and-biochemical-mechanism-of-rheum-officinale-in-chronic-renal-failure
#9
Zhi-Hao Zhang, Nosratola D Vaziri, Feng Wei, Xian-Long Cheng, Xu Bai, Ying-Yong Zhao
Chronic renal failure (CRF) is a major public health problem worldwide. Earlier studies have revealed salutary effects of rhubarb extracts in CRF. In this study, we employed lipidomic and metabolomic approaches to identify the plasma biomarkers and to determine the effect of treatment with petroleum ether, ethyl acetate and n-butanol extracts of rhubarb in a rat model of CRF with adenine-induced chronic tubulointerstitial nephropathy. In addition, clinical biochemistry, histological evaluation and pro-fibrotic protein expression were analyzed...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26780729/stress-hormone-potentiates-zn-2-induced-neurotoxicity-via-trpm7-channel-in-dopaminergic-neuron
#10
Yonjung Kim, Hyun Geun Oh, Yoon Young Cho, Oh-Hoon Kwon, Myoung Kyu Park, Sungkwon Chung
Zinc toxicity is one of the key factors responsible for the neuronal injuries associated with various neurological conditions. Zinc accumulation in some cells is accompanied by the increase of blood stress hormone levels, which might indicate a functional connection between stress and zinc toxicity. However, the cellular mechanism for the effect of stress on zinc toxicity is not known. Recently, it was reported that the zinc permeable transient receptor potential melastatin 7 (TRPM7) channel may represent a novel target for neurological disorders where zinc toxicity plays an important role...
February 5, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26605169/short-term-effect-of-percutaneous-bipolar-continuous-radiofrequency-on-sacral-nerves-in-patients-treated-for-neurogenic-detrusor-overactivity-after-spinal-cord-injury-a-randomized-controlled-feasibility-study
#11
Jin Hyun Kim, Sang Ho Ahn, Yun Woo Cho, Sang Gyu Kwak, Hyo Sung Kim
OBJECTIVE: To investigate the short-term effects of bipolar radiofrequency applied to sacral nerves to treat neurogenic detrusor overactivity in patients with spinal cord injury. METHODS: Ten patients with spinal cord injury with neurogenic detrusor overactivity were recruited. These subjects were randomized to two groups: intervention (n=5) and control (n=5), members of which received conventional treatment. Voiding diary, International Consultation on Incontinence Questionnaire (ICIQ) and the urinary incontinence quality of life scale (IQOL) data were obtained and an urodynamic study (UDS) was performed before and after intervention...
October 2015: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/26322503/apocynin-improving-cardiac-remodeling-in-chronic-renal-failure-disease-is-associated-with-up-regulation-of-epoxyeicosatrienoic-acids
#12
Kun Zhang, Yu Liu, Xiaoqiang Liu, Jie Chen, Qingqing Cai, Jingfeng Wang, Hui Huang
Cardiac remodeling is one of the most common cardiac abnormalities and associated with a high mortality in chronic renal failure (CRF) patients. Apocynin, a nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase inhibitor, has been showed cardio-protective effects. However, whether apocynin can improve cardiac remodeling in CRF and what is the underlying mechanism are unclear. In the present study, we enrolled 94 participants. In addition, we used 5/6 nephrectomized rats to mimic cardiac remodeling in CRF...
September 22, 2015: Oncotarget
https://www.readbyqxmd.com/read/26316045/cardiovascular-status-after-kawasaki-disease-in-the-uk
#13
COMPARATIVE STUDY
V Shah, G Christov, T Mukasa, K S Brogan, A Wade, D Eleftheriou, M Levin, R M Tulloh, B Almeida, M J Dillon, J Marek, N Klein, P A Brogan
OBJECTIVE: Kawasaki disease (KD) is an acute vasculitis that causes coronary artery aneurysms (CAA) in young children. Previous studies have emphasised poor long-term outcomes for those with severe CAA. Little is known about the fate of those without CAA or patients with regressed CAA. We aimed to study long-term cardiovascular status after KD by examining the relationship between coronary artery (CA) status, endothelial injury, systemic inflammatory markers, cardiovascular risk factors (CRF), pulse-wave velocity (PWV) and carotid intima media thickness (cIMT) after KD...
October 2015: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/26237966/-electroacupuncture-intervention-enhances-splenic-natural-killer-cell-activity-via-inhibiting-phosphorylation-of-erk-5-in-the-hypothalamus-of-surgically-traumatized-rats
#14
Yan Chen, Jing Li, Ke-ying Zhu, Sheng Xiao, Yan-qing Wang, Gen-cheng Wu, Jun Wang
OBJECTIVE: To observe the effect of electroacupuncture (EA) on cytotoxic activity of splenic natural killer (NK) cells after surgical trauma via extracellular signal-regulated kinase (ERK) 5 pathway in the rats' hypothalamus, so as to explore its mechanism underlying improving immune disorders after surgery. METHODS: Sprague-Dawley rats were randomly divided into the following 6 groups: control, trauma model, EA, sham EA, 4 nmol-BIX 02188 (an inhibitor for ERK 5 catalytic activity) and 20 nmol-BIX 02188 (n = 6 rats per group)...
June 2015: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/26136932/effect-of-shenkang-granules-on-the-progression-of-chronic-renal-failure-in-5-6-nephrectomized-rats
#15
Y U Zhang, Nan Zhou, Hongying Wang, Sicen Wang, Jianyu He
Shenkang granules (SKGs) are a Chinese herbal medicinal formula, consisting of rhubarb (Rheum palmatum L.), Salvia miltiorrhiza, milkvetch root [Astragalus membranaceus (Fisch.) Bunge] and safflower (Carthamus tinctorius L.). The aim of the present study was to investigate the effect of SKG on chronic renal failure (CRF) in 5/6 nephrectomized (5/6 Nx) rats. The rats were randomly divided into seven groups (n=10 per group) as follows: (i) 5/6 Nx (model group; 2.25 ml/kg/day normal saline); (ii) SKGL (low dose; 5/6 Nx treated with 2 g crude drug/kg/day SKG); (iii) SKGM (moderate dose; 5/6 Nx treated with 4 g crude drug/kg/day SKG); (iv) SKGH (high dose; 5/6 Nx treated with 8 g crude drug/kg/day SKG); (v) benazepril treatment group (5/6 Nx treated with 5 mg/kg/day benazepril); (vi) Shenkang injection (SKI) group (5/6 Nx with 13...
June 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/25956968/yishen-jiangzhuo-granules-affect-tubulointerstitial-fibrosis-via-a-mitochondrion-mediated-apoptotic-pathway
#16
Yan-fang Xu, Shi-wei Ruan, Jiu-mao Lin, Zheng Zhang
OBJECTIVE: To investigate the effect of Yishen Jiangzhuo Granules, YSJZG) on mitochondrial injury and regeneration and renal tubular epithelial cell apoptosis in chronic renal failure (CRF) rats and explore its mechanism from molecular pathology, gene, protein levels, and relative pathway. METHODS: The CRF rat model was established using 5/6 nephrectomy. Sixty rats were randomly divided into six groups: sham-operation group, model (CRF) group, Niaoduqing Granules-treated group [5 g/(kg...
December 2015: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/25937213/the-effect-of-trans-resveratrol-on-post-stroke-depression-via-regulation-of-hypothalamus-pituitary-adrenal-axis
#17
Cong Pang, Liang Cao, Fan Wu, Li Wang, Gang Wang, Yingcong Yu, Meixi Zhang, Lichao Chen, Weijie Wang, Weihong Lv, Ling Chen, Jiejin Zhu, Jianchun Pan, Hanting Zhang, Ying Xu, Lianshu Ding
Post-stroke depression (PSD) occurs about 40% among all stroke survivors, but the effective pharmacotherapy is inadequately understood. The present study investigated the effects of a natural polyphenol trans-resveratrol (RES) on behavioral changes after middle cerebral artery occlusion (MCAO) and examined what its molecular targets may be. RES was shown to decrease the infarct size and neurological scores after MCAO, suggesting the amelioration of brain damage and motor activity. RES also reversed the depressive-like behaviors 13 days after MCAO, both in the forced swimming and sucrose consumption tests...
October 2015: Neuropharmacology
https://www.readbyqxmd.com/read/25936181/-metyrapone-effect-on-gastroprotective-action-of-corticotropin-releasing-factor-administered-centrally-against-indomethacin-induced-gastric-injury
#18
M A Miazina, T R Bagaeva, L P Filaretova
In the present study, we investigated whether corticotropin-releasing factor (CRF) injected into the brain induces protection against indomethacin-caused gastric injury and the role of glucocorticoids in the protection. Gastric injury was caused by indomethacin (35 mg/kg, s.c.) in preliminary (24 h) fasted rats. CRF (10 microgram/rat, i.c.v.) was injected 30 min before administration of indomethacin. The participation of glucocorticoids was studied by metyrapone pretreatment (30 mg/kg, i.p., 30 min before CRF)...
December 2014: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
https://www.readbyqxmd.com/read/25924915/corticotropin-releasing-factor-receptor-expression-in-painful-human-dental-pulp
#19
Elizabeth Uhrich, Medha Gautam, John Hatton, Kevin Rowland
BACKGROUND: Our objective was to correlate the presence of symptoms and dental pulp injury with the amount of a subtype of corticotropin releasing factor receptor (CRF-R) in symptomatic and asymptomatic human teeth. We hypothesized that patients diagnosed with irreversible pulpitis have increased levels of CRF-R. MATERIALS AND METHODS: Dental history, diagnosis and radiographs were obtained from treatment records following extractions. Teeth were diagnosed as asymptomatic or symptomatic demonstrated by clinical and radiographic evaluation...
July 2015: Archives of Oral Biology
https://www.readbyqxmd.com/read/25632568/-effect-of-electroacupuncture-intervention-on-expression-of-pain-sensory-and-affection-processing-related-corticotropin-releasing-factor-receptor-mrna-etc-in-the-amygdala-in-neuropathic-pain-and-negative-affection-rats
#20
Xiu-mei Feng, Shu-ping Chen, Jun-ying Wang, Ya-xia Yan, Shu-bin Wang, Yong-hui Gao, Jian-liang Zhang, Jun-ling Liu
OBJECTIVE: To observe the effect of electroacupuncture .(EA) stimulation of "Zusanli" (ST 36)-"Yang- lingquan" (GB 34) on expression of pain sensory and affection processing-related corticotropin-releasing factor (CRF) receptor, glutamatergic NMDA receptor and GABA receptor subtype genes in the amygdala in chronic constrictive injury (CCI) of the sciatic nerve rats, so as to reveal its mechanism underlying pain relief. METHODS: Experiments were separately performed in 36 male Wistar rats which were randomized into normal control, CCI model and EA + CCI; normal control, CCI + negative affection (NA) model and CCl+ NA+ EA groups (n =6 in each group)...
December 2014: Zhen Ci Yan Jiu, Acupuncture Research
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