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Tom E Nightingale, Peter C Rouse, Jean-Philippe Walhin, Dylan Thompson, James L J Bilzon
OBJECTIVE: To assess the influence of a home-based exercise intervention on indices of health-related quality of life (HRQOL) in persons with spinal cord injury (SCI). DESIGN: This was a randomized controlled trial (HOMEX-SCI; ISRCTN57096451). After baseline laboratory testing and a week of free-living physical activity monitoring, eligible participants were randomly assigned (2:1 allocation ratio) to a home-based moderate-intensity upper-body exercise intervention (INT, n = 13), or a lifestyle maintenance control group (CON, n = 8), for 6 weeks...
June 11, 2018: Archives of Physical Medicine and Rehabilitation
Walid Abu Arab, Ibrahim Khadragui, Vincent Echavé, Annie Deshaies, Chantal Sirois, Marco Sirois
OBJECTIVE: Sternoclavicular joint (SCJ) infections are rarely encountered and their management is not well standardised. We reviewed our experience with the management of this condition in order to evaluate the role of surgery in the management of the SCJ infection and to provide an algorithm for its treatment. METHODS: It is a multicentre study in which we retrospectively reviewed the data files of the patients who were referred to us for surgical management of SCI infection...
September 2011: European Journal of Cardio-thoracic Surgery
Christy Rani R Grace, Marilyn H Perrin, Jozsef Gulyas, Jean E Rivier, Wylie W Vale, Roland Riek
The corticotropin-releasing factor (CRF) peptide hormone family members coordinate endocrine, behavioral, autonomic, and metabolic responses to stress and play important roles within the cardiovascular, gastrointestinal, and central nervous systems, among others. The actions of the peptides are mediated by activation of two G-protein-coupled receptors of the B1 family, CRF receptors 1 and 2 (CRF-R1 and CRF-R2α,β). The recently reported three-dimensional structures of the first extracellular domain (ECD1) of both CRF-R1 and CRF-R2β (Pioszak, A...
December 3, 2010: Journal of Biological Chemistry
Christy Rani R Grace, Laura Cervini, Jozsef Gulyas, Jean Rivier, Roland Riek
The C-terminally amidated CRF antagonist astressin binds to CRF-R1 or CRF-R2 receptors with low nanomolar affinity while the corresponding astressin-acid has >100 times less affinity. To understand the role of the amide group in binding, the conformations of astressin-amide and astressin-acid were studied in DMSO using NMR techniques. The 3D NMR structures show that the backbones of both analogs prefer an alpha-helical conformation, with a small kink around Gln(26). However, astressin-amide has a well-defined helical structure from Leu(27) to Ile(41) and a conformation very similar to the bioactive conformation reported by our group (Grace et al...
October 5, 2007: Biopolymers
J Rivier, S L Lahrichi, J Gulyas, J Erchegyi, S C Koerber, A G Craig, A Corrigan, C Rivier, W Vale
In three earlier publications (Miranda et al. J. Med. Chem. 1994, 37, 1450-1459; 1997, 40, 3651-3658; Gulyas et al. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 10575-10579) we have hypothesized that covalent constraints such as side-chain-to-side-chain lactam rings would stabilize an alpha-helical conformation shown to be important for the recognition and binding of the CRF C-terminus 30 residues, to CRF receptors. These studies led to the discovery of useful CRF antagonists such as alpha-helical CRF (alpha-hel-CRF) and Astressin both in vitro and in vivo...
July 2, 1998: Journal of Medicinal Chemistry
M Schäfer, S A Mousa, C Stein
Corticotropin-releasing factor (CRF) plays a major role at the level of the hypothalamus and pituitary to control the body's response mechanisms to stressful stimuli. The recent discovery of CRF outside the central nervous system suggests that CRF may well play a similar role in peripheral tissues, most likely in a paracrine manner. While its effects in many other peripheral tissues is not known yet, CRF and its receptors are upregulated in inflammatory pain states pointing to a key role under these circumstances...
March 26, 1997: European Journal of Pharmacology
J M Cruse, J C Keith, M L Bryant, R E Lewis
Multiple communicative pathways among the nervous, endocrine and immune systems facilitate physiological immunoregulation. Spinal cord injury (SCI) patients have decreased natural (NK cell) and adaptive (T cell) immune function and reduced blood levels of cellular adhesion molecules (CAMs) that participate in immune function and wound healing. We found decreased LFA-1 and VLA-4 on peripheral blood leukocytes in SCI patients and lower levels of CAMs in SCI patients with pressure ulcers than in those without them...
1996: Immunologic Research
N D Vaziri, S Gordon, B Nikakhtar
Serum lipid fractions were studied in ten patients with chronic renal failure (CRF) associated with long-standing spinal cord injury (SCI). A group of age-and-sex-matched patients with long-standing SCI but normal renal function were included for comparison. Serum triglycerides were markedly elevated in SCI-CRF patients. Both SCI groups exhibited moderate hypocholesterolemia. High density lipoprotein (HDL) cholesterol was severely reduced in the SCI-CRF group and moderately reduced in the SCI-control group...
June 1982: Paraplegia
N D Vaziri, R L Winer, J Toohey, K Danviriyasup, S Alikhani, I Eltorai, S Gordon, P Paule
Plasma procoagulant activities of factors XII, XI, IX, and VIII and plasma concentrations of factor XII antigen and high molecular weight kininogen (HMK) were determined in nine men with chronic renal failure (CRF) associated with long-standing spinal cord injury (SCI) treated with hemodialysis. The results were compared with those obtained in a group of 10 ambulatory CRF patients and 8 normal volunteers (control group). Congenitally deficient plasmas were used as the substrate for the measurement of procoagulant activities in a one-stage clotting assay...
May 1985: Artificial Organs
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