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https://www.readbyqxmd.com/read/28212532/long-non-coding-rna-ptenp1-functions-as-a-cerna-to-modulate-pten-level-by-decoying-mir-106b-and-mir-93-in-gastric-cancer
#1
Rupeng Zhang, Yuenan Guo, Zhenchi Ma, Gang Ma, Qiang Xue, Fangxuan Li, Liren Liu
Recent studies have shown that competing endogenous RNAs (ceRNAs) play an important role in the regulation of gene expression, and participate in a wide range of biological processes, including carcinogenesis. Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies. However, whether a PTENP1~miRNA~PTEN ceRNA network exists and how it functions in gastric cancer (GC) remains elusive. In order to identify and characterize the PTENP1~miRNA~PTEN ceRNA network in GC, we first determined PTENP1 levels in clinical GC samples and found that PTENP1 and PTEN were concurrently downregulated in these samples...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212138/deep-learning-in-mammography-diagnostic-accuracy-of-a-multipurpose-image-analysis-software-in-the-detection-of-breast-cancer
#2
Anton S Becker, Magda Marcon, Soleen Ghafoor, Moritz C Wurnig, Thomas Frauenfelder, Andreas Boss
OBJECTIVES: The aim of this study was to evaluate the diagnostic accuracy of a multipurpose image analysis software based on deep learning with artificial neural networks for the detection of breast cancer in an independent, dual-center mammography data set. MATERIALS AND METHODS: In this retrospective, Health Insurance Portability and Accountability Act-compliant study, all patients undergoing mammography in 2012 at our institution were reviewed (n = 3228). All of their prior and follow-up mammographies from a time span of 7 years (2008-2015) were considered as a reference for clinical diagnosis...
February 16, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28209059/phase-behavior-of-aqueous-suspension-of-laponite-new-insights-with-microscopic-evidence
#3
Shweta Jatav, Yogesh M Joshi
Investigating microstructure of suspensions with particles having anisotropic shape that share complex interactions is a challenging task leading to competing claims. This work investigates phase behavior of one such system: aqueous Laponite suspension, which is highly contested in the literature, using rheological and microscopic tools. Remarkably, we observe that over a broad range of Laponite (1.4 to 4 weight %) and salt concentrations (0 to 7 mM), the system overwhelmingly demonstrates all the rheological characteristics of the sol-gel transition leading to a percolated network...
February 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28207172/drivers-of-redistribution-of-fishing-and-non-fishing-effort-after-the-implementation-of-a-marine-protected-area-network
#4
Reniel B Cabral, Steven D Gaines, Brett A Johnson, Tom W Bell, Crow White
Marine spatial planning (MSP) is increasingly utilized to sustainably manage ocean uses. Marine protected areas (MPAs), a form of spatial management in which parts of the ocean are regulated to fishing, are now a common tool in MSP for conserving marine biodiversity and managing fisheries. However, the use of MPAs in MSP often neglects, or simplifies, the redistribution of fishing and non-fishing activities inside and outside of MPAs following their implementation. This redistribution of effort can have important implications for effective MSP...
October 3, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28196374/the-visual-white-matter-the-application-of-diffusion-mri-and-fiber-tractography-to-vision-science
#5
Ariel Rokem, Hiromasa Takemura, Andrew S Bock, K Suzanne Scherf, Marlene Behrmann, Brian A Wandell, Ione Fine, Holly Bridge, Franco Pestilli
Visual neuroscience has traditionally focused much of its attention on understanding the response properties of single neurons or neuronal ensembles. The visual white matter and the long-range neuronal connections it supports are fundamental in establishing such neuronal response properties and visual function. This review article provides an introduction to measurements and methods to study the human visual white matter using diffusion MRI. These methods allow us to measure the microstructural and macrostructural properties of the white matter in living human individuals; they allow us to trace long-range connections between neurons in different parts of the visual system and to measure the biophysical properties of these connections...
February 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28194982/porous-aromatic-framework-48-gel-hybrid-material-coated-solid-phase-microextraction-fiber-for-the-determination-of-the-migration-of-styrene-from-polystyrene-food-contact-materials
#6
Yuanyuan Jin, Zhongyue Li, Lei Yang, Jun Xu, Le Zhao, Zhonghao Li, Jiajia Niu
A novel solid-phase microextraction (SPME) fiber was fabricated by a porous aromatic framework 48 (PAF-48)/gel hybrid material through a sol-gel process. PAF-48 is a porous organic framework (POF) material that was polymerized from 1,3,5-triphenylbenzene. The uniform pore structure, high surface area, continuous conjugate network, and hydrophobicity make PAF-48 expected to have special abilities to absorb and extract styrene as well as some other harmful volatile aromatic compounds (VACs). The PAF-48/gel-coated fiber was explored for the extraction of styrene and six VACs (benzene, toluene, ethylbenzene, and xylenes) from aqueous food simulants followed by gas chromatography (GC) separation...
January 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28194254/long-term-continuous-ambulatory-ecg-monitors-and-external-cardiac-loop-recorders-for-cardiac-arrhythmia-a-health-technology-assessment
#7
(no author information available yet)
BACKGROUND: Ambulatory electrocardiography (ECG) monitors are often used to detect cardiac arrhythmia. For patients with symptoms, an external cardiac loop recorder will often be recommended. The improved recording capacity of newer Holter monitors and similar devices, collectively known as longterm continuous ambulatory ECG monitors, suggests that they will perform just as well as, or better than, external loop recorders. This health technology assessment aimed to evaluate the effectiveness, cost-effectiveness, and budget impact of longterm continuous ECG monitors compared with external loop recorders in detecting symptoms of cardiac arrhythmia...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28191928/self-assembling-multidomain-peptide-nanofibers-for-delivery-of-bioactive-molecules-and-tissue-regeneration
#8
Amanda N Moore, Jeffrey D Hartgerink
Multidomain peptides (MDPs) are a class of self-assembling peptides that are organized in a β-sheet motif, resulting in a nanofibrous architecture. This structure is stabilized by hydrophobic packing in the fiber core and a hydrogen-bonding network down the fiber long axis. Under easily controllable conditions, regulated by electrostatic interactions between the peptides and the pH and salt composition of the solvent, the nanofiber length can be dramatically extended, resulting in fiber entanglement and hydrogel formation...
February 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28187255/redox-route-from-inorganic-precursor-li2c2-to-nanopatterned-carbon
#9
Paul Simon, Xian-Juan Feng, Matej Bobnar, Peter Höhn, Ulrich Schwarz, Wilder Carrillo-Cabrera, Michael Baitinger, Yuri Grin
We present the synthesis route to carbon with hierarchical morphology on the nanoscale. The structures are generated using crystalline orthorhombic lithium carbide (Li2C2) as precursor with nanolamellar organization. Careful treatment by SnI4 oxidizes carbon at the fairly low temperature of 80 °C to the elemental state and keeps intact the initial crystallite shape, the internal lamellar texture of particles, and the lamellae stacking. The reaction product is amorphous but displays in the microstructure parallel band-like arrangements with diameters in the range of 200-500 nm...
February 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28186182/topological-determinants-of-self-sustained-activity-in-a-simple-model-of-excitable-dynamics-on-graphs
#10
Christoph Fretter, Annick Lesne, Claus C Hilgetag, Marc-Thorsten Hütt
Simple models of excitable dynamics on graphs are an efficient framework for studying the interplay between network topology and dynamics. This topic is of practical relevance to diverse fields, ranging from neuroscience to engineering. Here we analyze how a single excitation propagates through a random network as a function of the excitation threshold, that is, the relative amount of activity in the neighborhood required for the excitation of a node. We observe that two sharp transitions delineate a region of sustained activity...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28182140/enhancing-health-and-independent-living-for-veterans-with-disabilities-by-leveraging-community-based-resources
#11
Jennifer Hale-Gallardo, Huanguang Jia, Tony Delisle, Charles E Levy, Valentina Osorio, Jennifer A Smith, Elizabeth M Hannold
The number of US veterans with disabilities has increased in recent years as service members have returned home with extensive injuries and veterans from previous wars acquire functional limitations as a consequence of aging with chronic diseases. Veterans with severe disabilities need assistance and support to maintain independence at home and to avoid institutionalization. The US Department of Veterans Affairs (VA) strives to network with community organizations to achieve the best possible outcomes for veterans...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28173789/participatory-science-and-innovation-for-improved-sanitation-and-hygiene-process-and-outcome-evaluation-of-project-shine-a-school-based-intervention-in-rural-tanzania
#12
Erin Hetherington, Matthijs Eggers, Joyce Wamoyi, Jennifer Hatfield, Mange Manyama, Susan Kutz, Sheri Bastien
BACKGROUND: Diarrheal disease is a major cause of mortality and morbidity in low and middle income countries with children being disproportionately affected. Project SHINE (Sanitation & Hygiene INnovation in Education) is a grassroots participatory science education and social entrepreneurship model to engage youth and the wider community in the development of sustainable strategies to improve sanitation and hygiene. METHODS: Based in rural and remote Tanzania, this pilot study engaged pastoralist high-school students and communities in the development and evaluation of culturally and contextually relevant strategies to improve sanitation and hygiene...
February 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28167765/low-hesperian-pco2-constrained-from-in-situ-mineralogical-analysis-at-gale-crater-mars
#13
Thomas F Bristow, Robert M Haberle, David F Blake, David J Des Marais, Jennifer L Eigenbrode, Alberto G Fairén, John P Grotzinger, Kathryn M Stack, Michael A Mischna, Elizabeth B Rampe, Kirsten L Siebach, Brad Sutter, David T Vaniman, Ashwin R Vasavada
Carbon dioxide is an essential atmospheric component in martian climate models that attempt to reconcile a faint young sun with planetwide evidence of liquid water in the Noachian and Early Hesperian. In this study, we use mineral and contextual sedimentary environmental data measured by the Mars Science Laboratory (MSL) Rover Curiosity to estimate the atmospheric partial pressure of CO2 (PCO2) coinciding with a long-lived lake system in Gale Crater at ∼3.5 Ga. A reaction-transport model that simulates mineralogy observed within the Sheepbed member at Yellowknife Bay (YKB), by coupling mineral equilibria with carbonate precipitation kinetics and rates of sedimentation, indicates atmospheric PCO2 levels in the 10s mbar range...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28166613/melanocytic-nevus-count-and-dermoscopic-features-do-not-differ-in-psoriatic-patients-undergoing-biological-agent-versus-conventional-drug-therapy
#14
Serpil Pirmit, Nahide Onsun, Ozlem Su, Dilek B Ozkaya
BACKGROUND: Psoriasis is a chronic immune-mediated disease and treatment of psoriasis includes conventional immunosuppressive agents and biological agents. There are a few data on the relationship between psoriasis and melanocytic lesions. Either benign or malignant proliferations may be seen with immunosuppressive treatment. Eruptive nevi and malignant melanoma (MM) have been reported also associated with biological agents There is raising link biological treatment and malignancies. The objective of this paper is to examine the effects of biological agents versus conventional drugs on melanocytic nevi count and dermoscopical features...
April 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28161881/nutrient-loads-from-agricultural-and-forested-areas-in-finland-from-1981-up-to-2010-can-the-efficiency-of-undertaken-water-protection-measures-seen
#15
Sirkka Tattari, Jari Koskiaho, Maiju Kosunen, Ahti Lepistö, Jarmo Linjama, Markku Puustinen
Long-term data from a network of intensively monitored research catchments in Finland was analysed. We studied temporal (1981-2010) and spatial variability in nitrogen (N) and phosphorus (P), from 1987 losses, both from agricultural and forestry land. Based on trend analysis, total nitrogen (TN) concentrations increased in two of the four agricultural sites and in most of the forested sites. In agricultural catchments, the total phosphorus (TP) trends were decreasing in two of the four catchments studied. Dissolved P (DRP) concentrations increased in two catchments and decreased in one...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28161289/climbing-brain-levels-of-organisation-from-genes-to-consciousness
#16
REVIEW
Jean-Pierre Changeux
Given the tremendous complexity of brain organisation, here I propose a strategy that dynamically links stages of brain organisation from genes to consciousness, at four privileged structural levels: genes; transcription factors (TFs)-gene networks; synaptic epigenesis; and long-range connectivity. These structures are viewed as nested and reciprocally inter-regulated, with a hierarchical organisation that proceeds on different timescales during the course of evolution and development. Interlevel bridging mechanisms include intrinsic variation-selection mechanisms, which offer a community of bottom-up and top-down models linking genes to consciousness in a stepwise manner...
February 1, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28157932/ion-photon-entanglement-and-quantum-frequency-conversion-with-trapped-ba-sup-sup-ions
#17
J D Siverns, X Li, Q Quraishi
Trapped ions are excellent candidates for quantum nodes, as they possess many desirable features of a network node including long lifetimes, on-site processing capability, and production of photonic flying qubits. However, unlike classical networks in which data may be transmitted in optical fibers and where the range of communication is readily extended with amplifiers, quantum systems often emit photons that have a limited propagation range in optical fibers and, by virtue of the nature of a quantum state, cannot be noiselessly amplified...
January 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28157364/anderson-transition-for-classical-transport-in-composite-materials
#18
N Benjamin Murphy, Elena Cherkaev, Kenneth M Golden
The Anderson transition in solids and optics is a wave phenomenon where disorder induces localization of the wave functions. We find here that the hallmarks of the Anderson transition are exhibited by classical transport at a percolation threshold-without wave interference or scattering effects. As long range order or connectedness develops, the eigenvalue statistics of a key random matrix governing transport cross over toward universal statistics of the Gaussian orthogonal ensemble, and the field eigenvectors delocalize...
January 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28152748/patient-activation-measures-distress-levels-and-causes-of-distress-in-chronic-lymphocytic-leukemia
#19
Emily Van Laar, Uma Borate, Bradford E Jackson, Maria Pisu, Pamela M Peters, Thomas Wayne Butler, Randall S Davis, Amitkumar Mehta, Aras Acemgil, Sara J Knight, Monika M Safford, Gabrielle Betty Rocque
: 201 Background: Patients with chronic lymphocytic leukemia (CLL) reporting high levels of distress due to knowledge gaps and emotional concerns can have negative outcomes and suffer from lower quality of life. Understanding patients' activation levels, causes of distress, knowledge gaps, and psychosocial needs are crucial in high quality care. Optimally activated, educated and empowered patients are better positioned to communicate effectively with providers regarding selection of, and adherence to, CLL treatment protocols and long-term care plans, and potentially improving quality of life...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28145494/topological-characteristics-of-the-hong-kong-stock-market-a-test-based-p-threshold-approach-to-understanding-network-complexity
#20
Ronghua Xu, Wing-Keung Wong, Guanrong Chen, Shuo Huang
In this paper, we analyze the relationship among stock networks by focusing on the statistically reliable connectivity between financial time series, which accurately reflects the underlying pure stock structure. To do so, we firstly filter out the effect of market index on the correlations between paired stocks, and then take a t-test based P-threshold approach to lessening the complexity of the stock network based on the P values. We demonstrate the superiority of its performance in understanding network complexity by examining the Hong Kong stock market...
February 1, 2017: Scientific Reports
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