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https://www.readbyqxmd.com/read/27909439/the-a-allele-of-the-single-nucleotide-polymorphism-rs630923-creates-a-binding-site-for-mef2c-resulting-in-reduced-cxcr5-promoter-activity-in-b-cell-lymphoblastic-cell-lines
#1
Nikita A Mitkin, Alisa M Muratova, Anton M Schwartz, Dmitry V Kuprash
Chemokine receptor CXCR5 is highly expressed in B-cells and under normal conditions is involved in their migration to specific areas of secondary lymphoid organs. B-cells are known to play an important role in various autoimmune diseases including multiple sclerosis (MS) where areas of demyelinating lesions attract B-cells by overexpressing CXCL13, the CXCR5 ligand. In this study, we aimed to determine the functional significance of single-nucleotide polymorphism rs630923 (A/C), which is located in cxcr5 gene promoter, and its common allele is associated with increased risk of MS...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27906177/-normalizing-the-malignant-phenotype-of-luminal-breast-cancer-cells-via-alpha-v-beta-3-integrin
#2
Hanan Abu-Tayeh, Keren Weidenfeld, Alisa Zhilin-Roth, Sagi Schif-Zuck, Sonja Thaler, Cristina Cotarelo, Tuan Z Tan, Jean P Thiery, Jeffrey E Green, Geula Klorin, Edmond Sabo, Jonathan P Sleeman, Maty Tzukerman, Dalit Barkan
Reestablishing tissue organization of breast cancer cells into acini was previously shown to override their malignant phenotype. In our study, we demonstrate that alpha(v)beta(3) integrin (Int-αvβ3), previously shown to play a role in cancer progression, promoted differentiation and growth arrest of organoids derived from luminal A breast cancer cells grown in their relevant three-dimensional microenvironment. These organoids differentiated into normal-like acini resembling a benign stage of breast tissue...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27902285/raineyella-antarctica-gen-nov-sp-nov-a-novel-psychrotolerant-d-amino-acid-utilizing-anaerobe-isolated-from-two-geographic-locations-of-the-southern-hemisphere
#3
Elena V Pikuta, Rodolfo Javier Menes, Alisa Michelle Bruce, Zhe Lyu, Nisha Patel, Yuchen Liu, Richard Brice Hoover, Hans Jürgen Busse, Paul A Lawson, William Barney Whitman
Gram-positive bacterium, strain LZ-22T, was isolated from a rhizosphere of moss Leptobryum sp. collected at the shore of Lake Zub in Antarctica. Cells were motile, straight or pleomorphic rods with sizes of 0.6-1.0 x 3.5-10 μm. The new isolate was a facultatively anaerobic, catalase positive, psychrotolerant mesophile. Growth was observed at 3-41 oC (optimum 24-30 oC), 0-7 % NaCl, w/v (optimum, 0.25 %) and pH 4.0-9.0 (optimum 7.8). The quinone system of strain LZ-22T possessed predominately menaquinones MK-9(H4)...
October 12, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27894542/effect-of-orthodontic-treatment-on-the-upper-airway-volume-in-adults
#4
Benjamin T Pliska, Isaac T Tam, Alan A Lowe, Alisa M Madson, Fernanda R Almeida
INTRODUCTION: The aim of this study was to examine the effects of orthodontic treatment with and without extractions on the anatomic characteristics of the upper airway in adults. METHODS: For this retrospective study, the pretreatment and posttreatment cone-beam computed tomography scans of 74 adult patients meeting defined eligibility criteria were analyzed. Imaging software was used to segment and measure upper airway regions including the nasopharynx, the retropalatal, and retroglossal areas of the oropharynx, as well as the total airway...
December 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27894125/intronic-polyadenylation-of-pdgfr%C3%AE-in-resident-stem-cells-attenuates-muscle-fibrosis
#5
Alisa A Mueller, Cindy T van Velthoven, Kathryn D Fukumoto, Tom H Cheung, Thomas A Rando
Platelet-derived growth factor receptor α (PDGFRα) exhibits divergent effects in skeletal muscle. At physiological levels, signalling through this receptor promotes muscle development in growing embryos and angiogenesis in regenerating adult muscle. However, both increased PDGF ligand abundance and enhanced PDGFRα pathway activity cause pathological fibrosis. This excessive collagen deposition, which is seen in aged and diseased muscle, interferes with muscle function and limits the effectiveness of gene- and cell-based therapies for muscle disorders...
November 28, 2016: Nature
https://www.readbyqxmd.com/read/27890285/invertebrate-oncology-diseases-diagnostics-and-treatment
#6
REVIEW
Alisa L Newton, Gregory A Lewbart
Neoplasia is a documented occurrence across invertebrate taxa, but challenges remain with regard to tumor diagnosis and treatment. Literature reports of neoplasia are frequent in mollusks and insects, infrequent in Cnidaria and crustaceans, and are yet to be documented in Porifera and echinoderms. A significant contribution could be made by veterinary practitioners documenting and treating neoplasms in invertebrates. Traditional methods of veterinary diagnosis are encouraged, but the anatomy and tissue biology of each invertebrate species need to be considered...
January 2017: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/27888942/lessons-learned-from-two-decades-of-patient-and-family-centered-care-in-radiology-part-2-building-a-culture
#7
James V Rawson, Layne Mitchell, Lewis Golden, Alisa Murdock, G Rebecca Haines
As reimbursements are increasingly linked to patient experience, physicians and hospitals will need to find ways to incorporate patient and family input into operational decisions. Rather than starting from the beginning, health systems could learn from practitioners who have been experimenting in this space and are willing to share their experience. The authors share lessons learned from two decades of experience incorporating patient and family advisers into the clinical operation of a radiology department and the resulting culture change...
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27888941/lessons-learned-from-two-decades-of-patient-and-family-centered-care-in-radiology-part-1-getting-started
#8
James V Rawson, Layne Mitchell, Lewis Golden, Alisa Murdock, G Rebecca Haines
Patient- and family-centered care has a long history, but the application of these principles to radiology is limited by infrequent direct patient contact for many radiologists; scarce peer-reviewed data in the radiology literature; and sparse access to implementation strategies, tools, and best practices. In a series of two articles, the authors share two decades of lessons learned from implementing patient- and family-centered care in a radiology department.
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27887580/factors-associated-with-difficulty-accessing-health-care-for-infants-in-canada-mothers-reports-from-the-cross-sectional-maternity-experiences-survey
#9
Alisa D Brandon, Christy Costanian, Manal F El Sayed, Hala Tamim
BACKGROUND: Approximately 13% of Canadian mothers report difficulty accessing health care for their infants, yet little is known about the factors associated with difficulty. Therefore, we examined factors associated with difficulty accessing non-routine health care for Canadian infants, from birth to 14 months of age, as reported by their mothers. METHODS: Data was drawn from the Maternity Experiences Survey (MES), a cross-sectional, nationally representative survey of mothers who gave birth between November 2005 and May 2006, aged 15 years or older, and lived with their infants at the time of survey administration...
November 25, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27884764/targeted-direct-acting-antiviral-treatment-for-chronic-hepatitis-c-a-financial-reality-or-an-obstacle-to-elimination
#10
EDITORIAL
Margaret Hellard, Alisa Pedrana, Nick Scott
No abstract text is available yet for this article.
November 21, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27878206/new-findings-on-venous-thrombogenesis
#11
James R Byrnes, Alisa S Wolberg
Venous thrombosis (VT) is the third most common cause of cardiovascular death worldwide. Complications from VT and pulmonary embolism are the leading cause of lost disability-adjusted life years. Risks include genetic (e.g., non-O blood group, activated protein C resistance, hyperprothrombinemia) and acquired (e.g., age, surgery, cancer, pregnancy, immobilisation, female hormone use) factors. Pathophysiologic mechanisms that promote VT are incompletely understood, but involve abnormalities in blood coagulability, vessel function, and flow (so-called Virchow's Triad)...
November 23, 2016: Hämostaseologie
https://www.readbyqxmd.com/read/27873398/from-the-coliseum-to-the-convention-centre-a-reflection-on-the-current-state-of-medical-education-conferences-and-conference-goers
#12
Rebecca D Blanchard, Deborah L Engle, Lisa D Howley, Shari A Whicker, Alisa Nagler
The advancement of knowledge and development of policy in the field of medical education require critical academic discourse among the most intelligent medical educators; and critical academic discourse requires coffee. In this essay, we reflect on the state of professional development conferences in the field of medical education and the rituals that surround their success. Having begun in ancient Greece, symposia were ripe with debauchery. Today, sedated by the light brown walls of hotel conference centres, symposia are more serious endeavours, engaging men and women in the sometimes turbulent waters of epistemological debate...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27862604/whole-genome-sequencing-of-cytogenetically-balanced-chromosome-translocations-identifies-potentially-pathological-gene-disruptions-and-highlights-the-importance-of-microhomology-in-the-mechanism-of-formation
#13
Daniel Nilsson, Maria Pettersson, Peter Gustavsson, Alisa Förster, Wolfgang Hofmeister, Josephine Wincent, Vasilios Zachariadis, Britt-Marie Anderlid, Ann Nordgren, Outi Mäkitie, Valtteri Wirta, Max Käller, Francesco Vezzi, James R Lupski, Magnus Nordenskjöld, Elisabeth Syk Lundberg, Claudia M B Carvalho, Anna Lindstrand
Most balanced translocations are thought to result mechanistically from non-homologous endjoining (NHEJ) or, in rare cases of recurrent events, by nonallelic homologous recombination (NAHR). Here, we use low coverage mate pair whole genome sequencing to fine map rearrangement breakpoint junctions in both phenotypically normal and affected translocation carriers. In total, 46 junctions from 22 carriers of balanced translocations were characterized. Genes were disrupted in 48% of the breakpoints; recessive genes in four normal carriers and known dominant intellectual disability genes in three affected carriers...
November 16, 2016: Human Mutation
https://www.readbyqxmd.com/read/27836535/effect-of-the-herbicide-atrazine-and-its-metabolite-dact-on-bovine-sperm-quality
#14
Alisa Komsky-Elbaz, Zvi Roth
Atrazine (ATZ), one of the most extensively used herbicides, is considered a ubiquitous environmental contaminant. ATZ is a known endocrine disruptor, and deleterious effects on reproductive function have been shown, even at low, ecologically relevant doses (0.1-3μg/L). Once it enters the body, ATZ is metabolized to various metabolites, which are further detected in the urine, serum and tissues. In mammals, the major ATZ metabolite is diaminochlorotriazine (DACT). The current study focuses on direct effects of low doses of ATZ and DACT on bovine sperm isolated from ejaculates or epididymis compartments (head, body and tail)...
November 9, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27826811/inducible-de-novo-biosynthesis-of-isoflavonoids-in-soybean-leaves-by-spodoptera-litura-derived-elicitors-tracer-techniques-aided-by-high-resolution-lcms
#15
Ryu Nakata, Yuki Kimura, Kenta Aoki, Naoko Yoshinaga, Masayoshi Teraishi, Yutaka Okumoto, Alisa Huffaker, Eric A Schmelz, Naoki Mori
Isoflavonoids are a characteristic family of natural products in legumes known to mediate a range of plant-biotic interactions. For example, in soybean (Glycine max: Fabaceae) multiple isoflavones are induced and accumulate in leaves following attack by Spodoptera litura (Lepidoptera: Noctuidae) larvae. To quantitatively examine patterns of activated de novo biosynthesis, soybean (Var. Enrei) leaves were treated with a combination of plant defense elicitors present in S. litura gut content extracts and L-α-[(13)C9, (15)N]phenylalanine as a traceable isoflavonoid precursor...
November 8, 2016: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/27824753/naproxen-sodium-for-pain-control-with-intrauterine-device-insertion-a-randomized-controlled-trial
#16
Lynn L Ngo, Kari P Braaten, Eva Eichen, Jennifer Fortin, Rie Maurer, Alisa B Goldberg
OBJECTIVE: To evaluate whether 550 mg oral naproxen sodium given 1 hour before intrauterine device (IUD) insertion is effective for pain relief as compared with placebo. METHODS: This was a randomized, double-blind, placebo-controlled trial. The primary outcome was pain with IUD insertion measured on a 100-mm visual analog scale (VAS). Our sample size was calculated to detect a 15-mm difference in VAS scores with 80% power (α=0.05). Secondary outcomes included pain with tenaculum placement, uterine sounding, and 5 and 15 minutes postinsertion...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27814729/assessment-of-the-scope-and-practice-of-evaluation-among-medical-donation-programs
#17
Alisa M Jenny, Meng Li, Elizabeth Ashbourne, Myron Aldrink, Christine Funk, Andy Stergachis
BACKGROUND: Medical donation programs for drugs, other medical products, training and other supportive services can improve access to essential medicines in low- and middle-income countries (LMICs) and provide emergency and disaster relief. The scope and extent to which medical donation programs evaluate their impact on recipients and health systems is not well documented. METHODS: We conducted a survey of the member organizations of the Partnership for Quality Medical Donations (PQMD), a global alliance of non-profit and corporate organizations, to identify evaluations conducted in conjunction with donation programs...
November 4, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27812215/paradoxical-sensitivity-to-an-integrated-stress-response-blocking-mutation-in-vanishing-white-matter-cells
#18
Yusuke Sekine, Alisa Zyryanova, Ana Crespillo-Casado, Niko Amin-Wetzel, Heather P Harding, David Ron
The eukaryotic translation initiation factor eIF2B promotes mRNA translation as a guanine nucleotide exchange factor (GEF) for translation initiation factor 2 (eIF2). Endoplasmic reticulum (ER) stress-mediated activation of the kinase PERK and the resultant phosphorylation of eIF2's alpha subunit (eIF2α) attenuates eIF2B GEF activity thereby inducing an integrated stress response (ISR) that defends against protein misfolding in the ER. Mutations in all five subunits of human eIF2B cause an inherited leukoencephalopathy with vanishing white matter (VWM), but the role of the ISR in its pathogenesis remains unclear...
2016: PloS One
https://www.readbyqxmd.com/read/27810703/histone-deacetylase-and-acetyltransferase-inhibitors-modulate-behavioral-responses-to-social-stress
#19
Katharine E McCann, Anna M Rosenhauer, Genna M F Jones, Alisa Norvelle, Dennis C Choi, Kim L Huhman
Histone acetylation has emerged as a critical factor regulating learning and memory both during and after exposure to stressful stimuli. There are drugs that we now know affect histone acetylation that are already in use in clinical populations. The current study uses these drugs to examine the consequences of acutely increasing or decreasing histone acetylation during exposure to social stress. Using an acute model of social defeat in Syrian hamsters, we systemically and site-specifically administered drugs that alter histone acetylation and measured subsequent behavior and immediate-early gene activity...
January 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27809328/alchemical-screening-of-ionic-crystals
#20
Alisa Solovyeva, O Anatole von Lilienfeld
We introduce alchemical perturbations as a rapid and accurate tool to estimate fundamental structural and energetic properties in pure and mixed ionic crystals. We investigated formation energies, lattice constants, and bulk moduli for all sixteen iso-valence-electron combinations of pure pristine alkali halides involving elements Me ∈ {Na, K, Rb, Cs} and X ∈ {F, Cl, Br, I}. For rock salt, zinc-blende, and cesium chloride symmetry, alchemical Hellmann-Feynman derivatives, evaluated along lattice scans of sixteen reference crystals, have been obtained for coupling to all respective 16 × 15 target crystals...
November 16, 2016: Physical Chemistry Chemical Physics: PCCP
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