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Alisa Wray, Kathryn Bennett, Megan Boysen-Osborn, Warren Wiechmann, Shannon Toohey
Purpose: The aim of this study was to measure the effect of an iPad-based asynchronous curriculum on emergency medicine (EM) resident performance on the in-training exam (ITE). We hypothesized that the implementation of an asynchronous curriculum (replacing one hour of weekly didactic time) would result in non-inferior ITE scores compared to those scores from historical residents who had participated in the traditional five-hour weekly didactic curriculum. Methods: The study was a retrospective, non-inferiority, cohort study...
December 11, 2017: Journal of Educational Evaluation for Health Professions
René B Khan, Alisa Phulukdaree, Anil A Chuturgoon
Fumonisin B1 (FB1) is a ubiquitous contaminant of maize that is epidemiologically linked to oesophageal cancer (OC) in South Africa. FB1-induced oxidative stress mediates toxicity in animals and human cell lines, but the effects relating to OC are limited. Given the species-specific effects of FB1, this study investigated FB1-mediated toxicity and oxidative stress in spindle-shaped N-cadherin (+) CD45 (-) osteoblastic (SNO) cells. Following exposure to FB1 (0-20 μM) for 48 h, mitochondrial membrane potential and intracellular reactive oxygen species (iROS) were measured (flow cytometry)...
December 9, 2017: Toxicon: Official Journal of the International Society on Toxinology
Shields Callahan, Daniel R Mazori, Alisa N Femia
No abstract text is available yet for this article.
November 2017: Cutis; Cutaneous Medicine for the Practitioner
Erin Willis, Debopam Samanta, Alisa Kanfi
No abstract text is available yet for this article.
November 13, 2017: Pediatric Neurology
Alexandra L McCubbrey, Kristen C Allison, Alisa B Lee-Sherick, Claudia V Jakubzick, William J Janssen
Conditional and inducible Cre-loxP systems are used to target gene deletion to specific cell lineages and tissues through promoter-restricted expression of the bacterial DNA recombinase, Cre. Although Cre-loxP systems are widely used to target gene deletion in lung macrophages, limited data are published on the specificity and efficiency of "macrophage targeting" Cre lines. Using R26-stopfl/fl-TdTomato and tetOn-GFP reporter lines, we assessed the specificity and efficiency of four commercially available Cre driver lines that are often considered "macrophage specific...
2017: Frontiers in Immunology
Andreza Francisco Martins, Larissa Bail, Carmen Antonia Sanches Ito, Keite da Silva Nogueira, Tanise Vendruscolo Dalmolin, Amanda Silva Martins, Jaime Luis Lopes Rocha, Alisa W Serio, Felipe Francisco Tuon
Plazomicin is a next-generation aminoglycoside with activity against Enterobacteriaceae, including carbapenemase-producing Enterobacteriaceae (CPE). The aim of this study was to evaluate the activity of plazomicin against CPE (Klebsiella spp., Escherichia coli, Serratia spp., Enterobacter spp., Citrobacter spp., Morganella spp., Proteus spp., Providencia spp.) from different Brazilian hospitals. A total of 4000 carbapenem-resistant Enterobacteriaceae isolates were collected from clinical samples in 50 Brazilian hospitals during 2013-2015...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
Hildur Helgadottir, Håkan Olsson, Margaret A Tucker, Xiaohong R Yang, Veronica Höiom, Alisa M Goldstein
PurposeCarriers of CDKN2A mutations have high risks of melanoma and certain other cancers. In this study we examined the occurrence of tumors among CDKN2A wild type (wt) members of melanoma-prone families with CDKN2A mutations.MethodsSwedish and US melanoma-prone families with CDKN2A mutations were included. Data was collected on tumors diagnosed among family members. Among the CDKN2A mutated families, members with CDKN2A wt status who were diagnosed with melanoma were designated phenocopies.ResultsOf patients with melanoma in the CDKN2A mutated families (n = 266), 7...
December 7, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Michael Jaehme, Rajkumar Singh, Alisa A Garaeva, Ria H Duurkens, Dirk-Jan Slotboom
Membrane transporters of the bacterial pyridine nucleotide uptake (Pnu) family mediate the uptake of various B-type vitamins. For example, the PnuT transporters have specificity for vitamin B1 (thiamine). It has been hypothesized that Pnu transporters are facilitators that allow passive transport of the vitamin substrate across the membrane. Metabolic trapping by phosphorylation would then lead to accumulation of the transported substrates in the cytoplasm. However, experimental evidence for such a transport mechanism is lacking...
December 4, 2017: Journal of General Physiology
Deborah Bartz, Rie Maurer, Jessica Kremen, Jennifer M Fortin, Elizabeth Janiak, Alisa B Goldberg
Background: Depot medroxyprogesterone acetate (DMPA) contraceptive use is associated with an increased risk for Chlamydia infection. However, prior studies inadequately account for potential differences in sexual behavior between users of DMPA and users of other contraceptive methods. In this study we compare sexual risk-taking behavior in women using DMPA to women using oral contraceptive pills (OCP) to assess risk of Chlamydia trachomatis infection. Methods: In this cross-sectional study of 630 reproductive-aged women seeking routine gynecologic care (449 OCP and 181 DMPA users) sexual risk-taking was evaluated by use of the Safe Sex Behavior Questionnaire, a validated measure of sexual behaviors and attitudes...
2017: Contraception and Reproductive Medicine
Merry Krisdawati Sipahutar, Jittra Piapukiew, Alisa S Vangnai
For bioaugmentation-based treatment of triclocarban (TCC), an emerging soil pollutant that is recalcitrant to biodegradation and phytotransformation, efficient TCC-degrading bacteria with an effective soil-delivering means are required. This work developed the formulated bacterial inoculant, and successfully demonstrated its TCC removal and detoxification performance in pot soil experiment with Vigna radiata plants. The soil bacterium Pseudomonas fluorescens MC46 was isolated as TCC-degrading, plant-growth promoting bacterium...
November 27, 2017: Journal of Hazardous Materials
Natalia V Beloborodova, Yulia N Sarshor, Aleksandra Yu Bedova, Ekaterina A Chernevskaya, Alisa K Pautova
INTRODUCTION: We hypothesized that aromatic microbial metabolites (AMM), such as phenyllactic (PhLA), p-hydroxyphenylacetic (p-HPhAA), and p-hydroxyphenyllactic (p-HPhLA) acids, contribute to the pathogenesis of septic shock. METHODS: Clinical and laboratory data of patients with community-acquired pneumonia were obtained on intensive care unit admission and the next day. Patients were divided into two groups based on septic shock presence or absence. The levels of AMM (PhLA, p-HPhAA, p-HPhLA, and their sum, ∑3AMM), catecholamine metabolites (3,4-dihydroxymandelic [DHMA], 3,4-dihydroxyphenylacetic [DOPAC], and homovanillic [HVA] acids), lactate, N-terminal pro-brain natriuretic peptide (NT-proBNP), inducible nitric oxide synthase (iNOS), and procalcitonin (PCT) were compared...
November 15, 2017: Shock
Yuanita Lely Rachmawati, Alisa Novianty Pratiwi, Diah Ayu Maharani
Objective: Oral health-related quality of life (OHRQoL) questionnaires have been administered to children older than 6 years. Currently, the scale of oral health outcomes for 5-year-old children (SOHO-5) has been used to determine the OHRQoL through self-reports and parental proxy reports of children aged <6 years. This study was conducted to estimate the psychometric reliability and validity after adapting the SOHO-5 to the Indonesian language. Materials and Methods: The cross-cultural adaptation was tested in children aged 5 years old and their parents...
October 2017: Journal of International Society of Preventive & Community Dentistry
Renata Gudiukaite, Alisa Gricajeva
Genetic fusion of coding ORFs or connection of proteins in a post translational process are rather novel techniques to build products called fusion proteins that possess combined characteristics of their parental biomolecules. This attractive strategy used to create new enzymes not only diversifies their functionality by improving thermostability, thermo- and catalytic activity, substrate specificity, regio- or enantio-selectivity but also facilitates their purification and increases their yield. Many examples of microbial synthetic fusion biocatalysts are associated with fused enzymes that are involved in biomass degradation...
November 27, 2017: World Journal of Microbiology & Biotechnology
Alisa Wilantho, Pamornya Deekaew, Chutika Srisuttiyakorn, Sissades Tongsima, Naraporn Somboonna
Background: Skin microbiome varies from person to person due to a combination of various factors, including age, biogeography, sex, cosmetics and genetics. Many skin disorders appear to be related to the resident microflora, yet databases of facial skin microbiome of many biogeographies, including Thai, are limited. Methods: Metagenomics derived B-RISA and 16S rRNA gene sequencing was utilized to identify the culture-independent bacterial diversity on Thai male faces (cheek and forehead areas)...
2017: PeerJ
Alisa Sumkin, Michael J Magnetta, Ryan Anderson, Deborah Farkas, Margarita Zuley, Philip Orons, Marion Hughes
No abstract text is available yet for this article.
October 31, 2017: Current Problems in Diagnostic Radiology
Anna L Wilkinson, Bridget L Draper, Alisa E Pedrana, Jason Asselin, Martin Holt, Margaret E Hellard, Mark Stoove
INTRODUCTION: Contemporary responses to HIV embrace biomedical prevention, particularly treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP). However, large-scale implementation of biomedical prevention should be ideally preceded by assessments of their community acceptability. We aimed to understand contemporary attitudes of gay and bisexual men (GBM) in Australia towards biomedical-based HIV prevention and propose a framework for their measurement and ongoing monitoring...
November 21, 2017: Sexually Transmitted Infections
Alisa Yamasaki, Lloyd P Hoehle, Katie M Phillips, Adam P Campbell, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
No abstract text is available yet for this article.
November 2017: Annals of Allergy, Asthma & Immunology
Alisa Kachikis, Linda O Eckert, Christie Walker, Eugene Oteng-Ntim, Rama Guggilla, Manish Gupta, Manasi Patwardhan, Ronald Mataya, Tamala Mallett Moore, Ana Maria Alguacil-Ramos, Cheryl Keech, Michael Gravett, Helen Murphy, Sonali Kochhar, Nancy Chescheir
No abstract text is available yet for this article.
December 4, 2017: Vaccine
Malini DeSilva, Flor M Munoz, Erick Sell, Helen Marshall, Alison Tse Kawai, Alisa Kachikis, Paul Heath, Nicola P Klein, James M Oleske, Fyezah Jehan, Hans Spiegel, Mirjana Nesin, Beckie N Tagbo, Anju Shrestha, Clare L Cutland, Linda O Eckert, Sonali Kochhar, Azucena Bardají
No abstract text is available yet for this article.
December 4, 2017: Vaccine
Alisa Padon, Rajiv N Rimal
No abstract text is available yet for this article.
September 21, 2017: Journal of Public Health Research
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