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Oleg B Shevelev, Alisa A Seryapina, Evgenii L Zavjalov, Lyudmila A Gerlinskaya, Tatiana N Goryachkovskaya, Nikolay M Slynko, Leonid V Kuibida, Sergey E Peltek, Arcady L Markel, Mikhail P Moshkin
The presented data contains information about component composition of lipophilic compounds in Ganoderma lucidum fungal body sample obtained using gas chromatography and subsequent mass spectrometry.
June 2018: Data in Brief
Bouchra Edderkaoui, Liana Sargsyan, Alisa Hetrick, Hongzhe Li
Cochlear inflammatory response to various environmental insults, including acoustic and ototoxic overexposures, has been increasingly become a topic of interest. As the immune response is associated with both pathology and protection, targeting specific components of the immune response is expected to dissect the relationships between cellular damage and inflammation-associated protection and repair in the cochlea. Duffy antigen receptor for chemokines (DARC) is a member of a group of atypical chemokine receptors, and essential for chemokine-regulated leukocyte/neutrophil trafficking during inflammation...
2018: Frontiers in Molecular Neuroscience
Caitlin C Clements, Alisa R Zoltowski, Lisa D Yankowitz, Benjamin E Yerys, Robert T Schultz, John D Herrington
Importance: The social motivation hypothesis posits that individuals with autism spectrum disorder (ASD) find social stimuli less rewarding than do people with neurotypical activity. However, functional magnetic resonance imaging (fMRI) studies of reward processing have yielded mixed results. Objectives: To examine whether individuals with ASD process rewarding stimuli differently than typically developing individuals (controls), whether differences are limited to social rewards, and whether contradictory findings in the literature might be due to sample characteristics...
June 13, 2018: JAMA Psychiatry
Alisa A Suen, Wendy N Jefferson, Carmen J Williams, Charles E Wood
Developmental exposure to estrogenic chemicals is an established risk factor for cancer of the female reproductive tract. This increase in risk has been associated with disruption of normal patterns of cellular differentiation during critical stages of morphogenesis. The goal of this study was to document uterine epithelial phenotypes over time following neonatal treatment with the synthetic estrogen diethylstilbestrol (DES) or the soy phytoestrogen genistein (GEN) in female CD-1 mice. Both DES and GEN induced three distinct populations of abnormal endometrial epithelial cells: luminal (SIX1+/P63-/CK14-/CK18+), basal (SIX1+/P63+/CK14+/CK18-), and mixed/bipotential (SIX1+/P63-/CK14+/CK18+), which were all established by early adulthood...
January 1, 2018: Toxicologic Pathology
Anne E Cust, Martin Drummond, Peter A Kanetsky, Alisa M Goldstein, Jennifer H Barrett, Stuart MacGregor, Matthew H Law, Mark M Iles, Minh Bui, John L Hopper, Myriam Brossard, Florence Demenais, John C Taylor, Clive Hoggart, Kevin M Brown, Maria Teresa Landi, Julia A Newton-Bishop, Graham J Mann, D Timothy Bishop
It is unclear to what degree genomic and traditional (phenotypic and environmental) risk factors overlap in their prediction of melanoma risk. We evaluated the incremental contribution of common genomic variants (in pigmentation, nevus and other pathways) and their overlap with traditional risk factors, using data from two population-based case-control studies from Australia (n=1,035) and the UK (n=1,460) that used the same questionnaires. Polygenic risk scores were derived from 21 gene regions associated with melanoma and odds ratios from published meta-analyses...
June 8, 2018: Journal of Investigative Dermatology
Adam E Barry, Alisa A Padon, Shawn D Whiteman, Kristen K Hicks, Amie K Carreon, Jarrett R Crowell, Kristen L Willingham, Ashley L Merianos
BACKGROUND: There is considerable evidence that exposure to alcohol marketing increases the likelihood of adolescents initiating and engaging in alcohol consumption. There is a paucity of research, however, specifically examining industry generated alcohol marketing occurring on social media/networking platforms. OBJECTIVE: The purpose of this investigation was to analyze the content of promotional advertisements by alcohol brands on Instagram. METHODS: For a 30-day period, Instagram profiles of 15 distinct alcohol brands were examined...
June 11, 2018: Substance Use & Misuse
Semen V Nesterov, Yulia A Skorobogatova, Alisa A Panteleeva, Lyubov L Pavlik, Irina B Mikheeva, Lev S Yaguzhinsky, Yaroslav R Nartsissov
The purpose of this study is to demonstrate the presence of three more receptors in mitochondria. Two N-methyl-d-aspartate receptor (NMDAR) subunits (NR1 and NR2B) are found by protein immunoblot and immunogold labeling in mitochondria fraction isolated from rat heart. These data allow supposing NMDAR presence and functioning in the inner mitochondrial membrane. There are no signs of receptor presence obtained in heart tissue lysate, that indicates the receptor localization exactly in mitochondria. The possible receptor functions discussed are its participation in calcium transport and in excitation-metabolism coupling...
June 5, 2018: Chemico-biological Interactions
Alisa A Garaeva, Gert T Oostergetel, Cornelius Gati, Albert Guskov, Cristina Paulino, Dirk J Slotboom
Human ASCT2 belongs to the SLC1 family of secondary transporters and is specific for the transport of small neutral amino acids. ASCT2 is upregulated in cancer cells and serves as the receptor for many retroviruses; hence, it has importance as a potential drug target. Here we used single-particle cryo-EM to determine a structure of the functional and unmodified human ASCT2 at 3.85-Å resolution. ASCT2 forms a homotrimeric complex in which each subunit contains a transport and a scaffold domain. Prominent extracellular extensions on the scaffold domain form the predicted docking site for retroviruses...
June 2018: Nature Structural & Molecular Biology
Nattapol Tammachote, Alisa Seangleulur, Supakit Kanitnate
BACKGROUND: Pain control immediately following total knee arthroplasty (TKA) has been a focus for orthopaedists. However, control of subacute pain, which may persist up to 3 months, is usually not optimized. The efficacy of epidural corticosteroids in reducing pain after surgery is documented, but data on their efficacy in controlling subacute pain after TKA are lacking. Our aim was to investigate the efficacy of an epidural corticosteroid in controlling pain in the first 3 months following TKA using a double-blinded randomized clinical trial...
June 6, 2018: Journal of Bone and Joint Surgery. American Volume
Mariana Castanheira, Andrew P Davis, Rodrigo E Mendes, Alisa W Serio, Kevin M Krause, Robert K Flamm
Plazomicin and comparators agents were tested using the CLSI reference broth microdilution method against 4,825 clinical isolates collected during 2014 and 2015 in 70 United States hospitals as part of the ALERT (Antimicrobial Longitudinal Evaluation and Resistance Trends) program. Plazomicin (MIC50/90 , 0.5/2 μg/ml) inhibited 99.2% of 4,362 Enterobacteriaceae at ≤4 μg/ml. Amikacin, gentamicin, and tobramycin inhibited 98.9%, 90.3%, and 90.3% of these isolates, respectively, applying CLSI breakpoints. The activity of plazomicin was similar among Enterobacteriaceae species with MIC50 values ranging from 0...
June 4, 2018: Antimicrobial Agents and Chemotherapy
Alisa Ritthaphai, Methichit Wattanapanitch, Manop Pithukpakorn, Worapa Heepchantree, Rungtip Soi-Ampornkul, Panchalee Mahaisavariya, Daranporn Triwongwaranat, Kovit Pattanapanyasat, Chinnavuth Vatanashevanopakorn
Dermal fibroblasts were obtained from a 48-year-old female patient with spinocerebellar ataxia type 3 (SCA3). Fibroblasts were reprogrammed by nucleofection with episomal plasmids, carrying L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1 and shRNA against p53. The SCA3 patient-specific iPSC line, MUSIi004-A, was characterized by immunofluorescence staining to verify the expression of pluripotent markers. The iPSC line exhibited an ability to differentiate into three germ layers by embryoid body (EB) formation. Karyotypic analysis of the MUSIi004-A line was normal...
May 21, 2018: Stem Cell Research
Vladislav A Parfenov, Elizaveta V Koudan, Elena A Bulanova, Pavel A Karalkin, Frederico DAS Pereira, Nikita E Norkin, Alisa D Knyazeva, Anna A Gryadunova, Oleg F Petrov, M M Vasiliev, Maxim Myasnikov, Valery P Chernikov, Vladimir A Kasyanov, Artem Yu Marchenkov, Kenneth A Brakke, Yusef D Khesuani, Utkan Demirci, Vladimir A Mironov
Tissue spheroids have been proposed as building blocks in 3D biofabrication. Conventional magnetic force-driven 2D patterning of tissue spheroids requires prior cell labeling by magnetic nanoparticles, meanwhile a label-free approach for 3D magnetic levitational assembly has been introduced. Here we present first-time report on rapid assembly of 3D tissue construct using scaffold-free, nozzle-free and label-free magnetic levitation of tissue spheroids. 
 Chondrospheres of standard size, shape and capable to fusion have been biofabricated from primary sheep chondrocytes using non-adhesive technology...
May 31, 2018: Biofabrication
Volodymyr V Oberemok, Kateryna V Laikova, Anna I Repetskaya, Igor M Kenyo, Mikhail V Gorlov, Igor N Kasich, Alisa M Krasnodubets, Nikita V Gal'chinsky, Iryna I Fomochkina, Aleksei S Zaitsev, Viktoriya V Bekirova, Eleonora E Seidosmanova, Ksenia I Dydik, Anna O Meshcheryakova, Sergey A Nazarov, Natalya N Smagliy, Edie L Chelengerova, Alina A Kulanova, Karim Deri, Mikhail V Subbotkin, Refat Z Useinov, Maksym N Shumskykh, Anatoly V Kubyshkin
Antisense oligonucleotides (ASO), short single-stranded polymers based on DNA or RNA chemistries and synthesized in vitro, regulate gene expression by binding in a sequence-specific manner to an RNA target. The functional activity and selectivity in the action of ASOs largely depends on the combination of nitrogenous bases in a target sequence. This simple and natural property of nucleic acids provides an attractive route by which scientists can create different ASO-based techniques. Over the last 50 years, planned and realized applications in the field of antisense and nucleic acid nanotechnologies have produced astonishing results and posed new challenges for further developments, exemplifying the essence of the post-genomic era...
May 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Alisa Kachikis, Ann-Beth Moller, Tomas Allen, Lale Say, Doris Chou
INTRODUCTION: Equity is a cross-cutting theme within the Sustainable Development Goals (SDGs) and central to the effort to improve maternal and child health globally. One key strategy to prevent maternal death set out in SDG 3 is assistance by a skilled birth attendant (SBA) at childbirth (indicator 3.1.2). However, the increased coverage of SBAs globally has not been reflected by the same degree of decrease in maternal mortality and has been reported to have higher levels of inequality than other maternal health interventions...
May 26, 2018: BMJ Open
Csenge Szeverenyi, Zoltan Kekecs, Alisa Johnson, Gary Elkins, Zoltan Csernatony, Katalin Varga
The present study aims to assess the effectiveness of psychosocial techniques to decrease postoperative pain and improve perioperative clinical care in orthopedic surgery. A systematic review and meta-analysis was performed to evaluate the effects of psychosocial methods among adults undergoing orthopedic surgeries. The systematic review included both randomized and non-randomized trials, but only randomized controlled clinical trials (RCTs) were included in the meta-analysis. Key outcomes were postoperative pain, analgesic requirement, perioperative anxiety, quality of life, and recovery...
May 24, 2018: Journal of Pain: Official Journal of the American Pain Society
Cosimo Damiano Altomare, Alisa A Nevskaya, Maria D Matveeva, Tatiana N Borisova, Mauro Niso, Nicola Antonio Colabufo, Angelina Boccarelli, Rosa Purgatorio, Modesto de Candia, Saverio Cellamare, Leonid G Voskressensky
A number of aza-heterocyclic compounds, which share with members of the lamellarin alkaloids' family the 5,6-dihydropyrrolo[2,1-a]isoquinoline (DHPIQ) scaffold, were synthesized and evaluated for their ability to reverse in vitro multidrug resistance (MDR) in cancer cells, through inhibition of P-glycoprotein (P-gp) and/or multidrug-resistance-associated protein-1 (MRP-1). Most of the investigated DHPIQs proved to be selective P-gp modulators, and the most potent ones, which are 2-carbaldehydes (3 and 4) or a thiosemicarbazone derivative (10), attained submicromolar inhibition potencies (average IC50s of 0...
May 26, 2018: ChemMedChem
Amir Arav, Yehudit Natan, Dorit Kalo, Alisa Komsky-Elbaz, Zvika Roth, Paolo Emanuele Levi-Setti, Milton Leong, Pasquale Patrizio
PURPOSE: This paper reports the use of a novel automatic vitrification device (Sarah, Fertilesafe, Israel) for cryopreservation of oocytes and embryos. METHODS: Mice oocytes (n = 40) and embryos (8 cells, n = 35 and blastocysts, n = 165), bovine embryos (2PN, n = 35), and MII oocytes (n = 84) were vitrified using this automated device. A total of 42 (2 cells) mice embryos, 20 (2PN) bovine embryos, and 150 MII bovine oocytes were used as fresh controls and grown to blastocysts...
May 25, 2018: Journal of Assisted Reproduction and Genetics
Alisa Baron, Lisa M Bedore, Elizabeth D Peña, Samantha D Lovgren-Uribe, Amanda A López, Elizabeth Villagran
Purpose: The purpose of this analysis was to understand how grammatical morpheme production in Spanish for typically developing Spanish-English bilingual children relates to mean length of utterance in words (MLUw) and the extent to which different bilingual profiles influence order of grammatical morpheme acquisition. Method: Participants included 228 Spanish-English bilingual children ages 4;0-7;6 (years;months). Grammatical morpheme accuracy was evaluated using an experimental version of the Bilingual English-Spanish Assessment (Peña, Gutiérrez-Clellen, Iglesias, Goldstein, & Bedore, 2014)...
May 9, 2018: American Journal of Speech-language Pathology
Gudrun Kaiser, Alisa Schormann, Johanna N Kues, Cornelia Weise
No abstract text is available yet for this article.
May 22, 2018: Psychotherapy and Psychosomatics
Vadym V Biloshytskyi, Alisa V Pachevska, Alina V Biloshytska, Valerii M Istoshyn, Maryna V Biloshytska, Olha B Shevnia
OBJECTIVE: Introduction: In recent years, a stroke has been the cause of high lethality, long-term and sustained disability, the problem of which is still far from being resolved. The root cause of stroke is atherosclerosis. The aim: Study of neurotrophic and neuroprotective functions of apoE in rat brain tissue in experimental atherosclerosis. PATIENTS AND METHODS: Materials and methods: The study included 60 sexually mature rats. The model of experimental atherosclerosis was created by Anichkov method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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