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https://www.readbyqxmd.com/read/29028942/association-of-high-evidence%C3%A2-gastric-cancer%C3%A2-susceptibility-loci-and-somatic-gene-expression-levels-with-survival
#1
Hyuna Sung, Nan Hu, Howard H Yang, Carol A Giffen, Bin Zhu, Lei Song, Hua Su, Chaoyu Wang, Dominick M Parisi, Alisa M Goldstein, Philip R Taylor, Paula L Hyland
Eleven high-evidence single-nucleotide polymorphisms (SNPs) at 9 loci for gastric cancer (GC) risk were reported, but their associations with survival remains unknown. In this study, we examined associations between SNP and GC survival by anatomic location and histology among 1147 incident cases from the Shanxi Upper Gastrointestinal Genetics Project. We further examined if SNPs were expression quantitative trait loci (eQTL) in normal and tumor gastric tissues, and whether tumor vs. normal somatic mRNA differences in 126 cases were associated with survival...
September 27, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028287/a-validated-model-for-the-22-item-sino-nasal-outcome-test-subdomain-structure-in-chronic-rhinosinusitis
#2
Allen L Feng, Nicholas C Wesely, Lloyd P Hoehle, Katie M Phillips, Alisa Yamasaki, Adam P Campbell, Luciano L Gregorio, Thomas E Killeen, David S Caradonna, Josh C Meier, Stacey T Gray, Ahmad R Sedaghat
BACKGROUND: Previous studies have identified subdomains of the 22-item Sino-Nasal Outcome Test (SNOT-22), reflecting distinct and largely independent categories of chronic rhinosinusitis (CRS) symptoms. However, no study has validated the subdomain structure of the SNOT-22. This study aims to validate the existence of underlying symptom subdomains of the SNOT-22 using confirmatory factor analysis (CFA) and to develop a subdomain model that practitioners and researchers can use to describe CRS symptomatology...
October 13, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29020471/culture-positive-endogenous-endophthalmitis-an-eleven-year-retrospective-study-in-the-central-region-of-thailand
#3
Sukhum Silpa-Archa, Alisa Ponwong, Janine M Preble, C Stephen Foster
PURPOSE: To report the characteristics of infection and prognostic factors of endogenous endophthalmitis (EE) over an 11-year period. METHODS: The clinical records of 41 eyes of 36 patients diagnosed with culture-proven EE at the Rajavithi Hospital were retrospectively reviewed. RESULTS: Median age at presentation was 58 years. Liver abscess (19%) and urinary tract infections (19%) were the most common sources of infection. The most common causative agents were gram-negative organisms (48%)...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29018598/the-plasmodium-berghei-rc-strain-is-highly-diverged-and-harbors-putatively-novel-drug-resistance-variants
#4
Warangkhana Songsungthong, Supasak Kulawonganunchai, Alisa Wilantho, Sissades Tongsima, Pongpisid Koonyosying, Chairat Uthaipibull, Sumalee Kamchonwongpaisan, Philip J Shaw
BACKGROUND: The current first line drugs for treating uncomplicated malaria are artemisinin (ART) combination therapies. However, Plasmodium falciparum parasites resistant to ART and partner drugs are spreading, which threatens malaria control efforts. Rodent malaria species are useful models for understanding antimalarial resistance, in particular genetic variants responsible for cross resistance to different compounds. METHODS: The Plasmodium berghei RC strain (PbRC) is described as resistant to different antimalarials, including chloroquine (CQ) and ART...
2017: PeerJ
https://www.readbyqxmd.com/read/29018540/efficacy-of-individualised-diets-in-patients-with-irritable-bowel-syndrome-a-randomised-controlled-trial
#5
Ather Ali, Theresa R Weiss, Douglas McKee, Alisa Scherban, Sumiya Khan, Maxine R Fields, Damian Apollo, Wajahat Z Mehal
BACKGROUND: Patients with irritable bowel syndrome (IBS) are often placed on diets guided by food intolerance assays, although these have not been validated. We assessed the effects of individualised diets in patients with IBS guided by a leucocyte activation test. METHODS: This is a parallel-group, double-blind, randomised controlled trial of 58 adults with IBS seen at an academic health centre in Northeast USA. Peripheral venous blood was analysed using a leucocyte activation test; individual foods were reported to produce positive or negative results...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29017561/trial-and-error-evaluating-and-refining-a-community-model-of-hiv-testing-in-australia
#6
Kathleen E Ryan, Alisa Pedrana, David Leitinger, Anna L Wilkinson, Peter Locke, Margaret E Hellard, Mark Stoové
BACKGROUND: The 2012 regulatory approval of HIV rapid point of care (RPOC) tests in Australia and a national strategic focus on HIV testing provided a catalyst for implementation of non-clinical HIV testing service models. PRONTO! opened in 2013 as a two-year trial delivering peer-led community-based HIV RPOC tests targeting gay, bisexual and other men who have sex with men (GBM), with the aim of increasing HIV testing frequency. Initial data suggested this aim was not achieved and, as part of a broader service evaluation, we sought to explore client acceptability and barriers to testing at PRONTO! to refine the service model...
October 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28992250/equivalency-of-the-quality-of-sublethal-lesions-after-photons-and-high-linear-energy-transfer-ion-beams
#7
Yoshiya Furusawa, Mizuho Nakano-Aoki, Yoshitaka Matsumoto, Ryoichi Hirayama, Alisa Kobayashi, Teruaki Konishi
The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Accelerator in the Chiba facility. The cells were kept at room temperature and then exposed to a secondary test dose of X-rays. Based on the repair kinetics study, the surviving fraction of cells quickly increased with the repair time, and reached a plateau in 2-3 h, even when cells had received priming monoenergetic high-LET beams or spread-out Bragg peak beams as well as X-ray irradiation...
July 11, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28990841/utilization-patterns-of-systemic-corticosteroid-use-for-chronic-rhinosinusitis
#8
Stacey T Gray, Katie M Phillips, Lloyd P Hoehle, Allen L Feng, Alisa Yamasaki, David S Caradonna, Ahmad R Sedaghat
OBJECTIVE: We sought to characterize the utilization pattern and factors associated with use of systemic corticosteroids for CRS. METHODS: This was a cross-sectional study of 236 participants with CRS who were prospectively recruited. Participants reported the number of CRS-related oral corticosteroid courses taken in the last year. Baseline CRS symptomatology was measured using the 22-item Sinonasal Outcome Test (SNOT-22) and SNOT-22 sleep, nasal, otologic/facial pain and emotional subdomain scores...
October 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28988363/safety-of-shortened-infusion-times-for-combined-ipilimumab-and-nivolumab
#9
Maximilian Gassenmaier, Hans-Peter Lipp, Alexander Scheu, Nikolaus Benjamin Wagner, Lukas Kofler, Alisa Mueller, Dennis Doecker, Thomas Kurt Eigentler, Claus Garbe, Andrea Forschner
BACKGROUND: Combined ipilimumab and nivolumab induces encouraging response rates in patients with unresectable or metastatic melanoma. However, the approved protocol for dual checkpoint inhibition (3 mg/kg ipilimumab over 90 min and 1 mg/kg nivolumab over 60 min) is time-intensive and several trials have shown that both single agents can be safely administered at faster infusion rates. AIM: To investigate whether combined checkpoint inhibition with 3 mg/kg ipilimumab and 1 mg/kg nivolumab can be safely administered over 30 min per agent...
October 7, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28980502/marginal-structural-models-to-estimate-the-effects-of-time-varying-treatments-on-clustered-outcomes-in-the-presence-of-interference
#10
Jiwei He, Alisa Stephens-Shields, Marshall Joffe
Marginal structural models are a class of causal models useful for characterizing the effect of treatment in the presence of time-varying confounding. They are more widely used than structural nested models, partly because these models are easier to understand and to implement. We extend marginal structural models to situations with clustered observations with unit- and cluster-level treatment and introduce an appropriate inferential method. We consider how to formulate models with cluster-level and unit-level treatments...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28942660/pathways-to-the-elimination-of-hepatitis-c-prioritising-access-for-all
#11
Alisa E Pedrana, Rachel Sacks-Davis, Joseph S Doyle, Margaret E Hellard
No abstract text is available yet for this article.
September 25, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28942199/metabolomic-findings-in-sepsis-as-a-damage-of-host-microbial-metabolism-integration
#12
REVIEW
Natalia V Beloborodova, Andrei Yu Olenin, Alisa K Pautova
Metabolomics globally evaluates the totality of the endogenous metabolites in patient's body, at the same time reflecting gene function, enzyme activity and degree of organ dysfunction in sepsis. The authors performed the analysis of the main chemical classes of low molecular weight compounds (amino acids, polyols, fatty acids, hydroxy acids, amines, nucleotides and their derivatives) that quantitatively distinguish patients with sepsis from healthy ones. The following keywords were used to find papers published in the Scopus and Web of Science databases from 2008 to 2015: (marker OR biomarker) AND (sepsis OR critical ill OR pneumonia OR hypoxia)...
September 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28941773/exploring-the-associations-between-parent-reported-biological-indoor-environment-and-airway-related-symptoms-and-allergic-diseases-in-children
#13
Alisa Weber, Nina Fuchs, Susanne Kutzora, Lana Hendrowarsito, Uta Nennstiel-Ratzel, Erika von Mutius, Caroline Herr, Stefanie Heinze
OBJECTIVES: Asthma and allergic rhinitis are diseases which require special attention in childhood. Risk factors for these diseases are manifold and include environmental factors. Previous studies have shown associations between indoor mould and respiratory diseases in children. Besides indoor mould, organic waste storage, potted plants, pets and crowding could influence the microbial indoor environment at home and the respiratory health of children. Our aim was therefore to explore the associations of these factors with airway-related symptoms and respiratory diseases in preschoolers...
September 6, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28939843/macrophage-released-adamts1-promotes-muscle-stem-cell-activation
#14
Hongqing Du, Chung-Hsuan Shih, Michael N Wosczyna, Alisa A Mueller, Joonseok Cho, Abhishek Aggarwal, Thomas A Rando, Brian J Feldman
Coordinated activation of muscle stem cells (known as satellite cells) is critical for postnatal muscle growth and regeneration. The muscle stem cell niche is central for regulating the activation state of satellite cells, but the specific extracellular signals that coordinate this regulation are poorly understood. Here we show that macrophages at sites of muscle injury induce activation of satellite cells via expression of Adamts1. Overexpression of Adamts1 in macrophages in vivo is sufficient to increase satellite cell activation and improve muscle regeneration in young mice...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28937651/perennial-grass-and-native-wildflowers-a-synergistic-approach-to-habitat-management
#15
Shereen S Xavier, Dawn M Olson, Alisa W Coffin, Timothy C Strickland, Jason M Schmidt
Marginal agricultural land provides opportunities to diversify landscapes by producing biomass for biofuel, and through floral provisioning that enhances arthropod-mediated ecosystem service delivery. We examined the effects of local spatial context (adjacent to woodland or agriculture) and irrigation (irrigation or no irrigation) on wildflower bloom and visitation by arthropods in a biofeedstocks-wildflower habitat buffer design. Twenty habitat buffer plots were established containing a subplot of Napier grass (Pennisetum perpureum Schumach) for biofeedstock, three commercial wildflower mix subplots, and a control subplot containing spontaneous weeds...
September 22, 2017: Insects
https://www.readbyqxmd.com/read/28931629/selinene-volatiles-are-essential-precursors-for-maize-defense-promoting-fungal-pathogen-resistance
#16
Yezhang Ding, Alisa Huffaker, Tobias G Köllner, Philipp Weckwerth, Christelle A M Robert, Joseph L Spencer, Alexander E Lipka, Eric A Schmelz
To ensure food security, maize (Zea mays) is a model crop for understanding useful traits underlying stress resistance. In contrast to foliar biochemicals, root defenses limiting the spread of disease remain poorly described. To better understand below-ground defenses in the field, we performed root metabolomic profiling and uncovered unexpectedly high levels of the sesquiterpene volatile β-selinene and the corresponding non-volatile antibiotic derivative, β-costic acid. The application of metabolite-based quantitative trait loci (mQTL) mapping using bi-parental populations, genome wide association studies, and near-isogenic lines (NILs) enabled the identification of terpene synthase 21 (ZmTps21) on chromosome 9 as a β-costic acid pathway candidate gene...
September 20, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28931593/active-ran-regulates-anillin-function-during-cytokinesis
#17
Daniel Beaudet, Tara Akhshi, Julia Phillipp, Christopher Law, Alisa Piekny
Cytokinesis cleaves a cell into two daughters at the end of mitosis, and must be spatially coordinated with chromosome segregation to prevent aneuploidy. The dogma is that the mitotic spindle governs the assembly and constriction of an actomyosin ring. Here, we reveal a function for active Ran in spatially restricting the ring. Our model is that during anaphase, 'free' importins, whose gradient inversely correlates with active Ran and chromatin position, function as a molecular ruler for the recruitment and localization of anillin, a contractile protein and crucial regulator of cytokinesis...
September 20, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28928616/chronic-antepartum-maternal-hyperoxygenation-in-a-case-of-severe-fetal-ebstein-s-anomaly-with-circular-shunt-physiology
#18
Alisa Arunamata, David M Axelrod, Katherine Bianco, Sowmya Balasubramanian, Amy Quirin, Theresa A Tacy
Perinatal mortality remains high among fetuses diagnosed with Ebstein's anomaly of the tricuspid valve. The subgroup of patients with pulmonary valve regurgitation is at particularly high risk. In the setting of pulmonary valve regurgitation, early constriction of the ductus arteriosus may be a novel perinatal management strategy to reduce systemic steal resulting from circular shunt physiology. We report the use of chronic antepartum maternal oxygen therapy for constriction of the fetal ductus arteriosus and modulation of fetal pulmonary vascular resistance in a late presentation of Ebstein's anomaly with severe tricuspid valve regurgitation, reversal of flow in the ductus arteriosus, and continuous pulmonary valve regurgitation...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28924262/prenatal-glucocorticoid-exposure-modifies-endocrine-function-and-behaviour-for-3-generations-following-maternal-and-paternal-transmission
#19
Vasilis G Moisiadis, Andrea Constantinof, Alisa Kostaki, Moshe Szyf, Stephen G Matthews
Fetal exposure to high levels of glucocorticoids programs long-term changes in the physiologic stress response and behaviours. However, it is not known whether effects manifest in subsequent generations of offspring following maternal (MT) or paternal (PT) transmission. We treated pregnant guinea pigs with three courses of saline or synthetic glucocorticoid (sGC) at a clinically relevant dose. Altered cortisol response to stress and behaviours transmitted to juvenile female and male F2 and F3 offspring from both parental lines...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28919002/x-linked-adrenoleukodystrophy-in-a-chimpanzee-due-to-an-abcd1-mutation-reported-in-multiple-unrelated-humans
#20
Julian Curiel, Steven Jeffrey Steinberg, Sarah Bright, Ann Snowden, Ann B Moser, Florian Eichler, Holly A Dubbs, Joseph G Hacia, John J Ely, Jocelyn Bezner, Alisa Gean, Adeline Vanderver
BACKGROUND: X-linked adrenoleukodystrophy (X-ALD) is a genetic disorder leading to the accumulation of very long chain fatty acids (VLCFA) due to a mutation in the ABCD1 gene. ABCD1 mutations lead to a variety of phenotypes, including cerebral X-ALD and adrenomyeloneuropathy (AMN) in affected males and 80% of carrier females. There is no definite genotype-phenotype correlation with intrafamilial variability. Cerebral X-ALD typically presents in childhood, but can also present in juveniles and adults...
September 1, 2017: Molecular Genetics and Metabolism
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