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https://www.readbyqxmd.com/read/28102760/phf13-a-new-player-involved-in-rna-polymerase-ii-transcriptional-regulation-and-co-transcriptional-splicing
#1
Alisa Fuchs, Marcos Torroba, Sarah Kinkley
We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13's interactome. Here we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.
January 19, 2017: Transcription
https://www.readbyqxmd.com/read/28102623/ischemic-stroke-in-kawasaki-disease
#2
Wasana Prangwatanagul, Alisa Limsuwan
Pediatric stroke is considered to be rare. Stroke resulting from cerebral vasculitis is also uncommon in young children. With the increasing prevalence of Kawasaki disease (KD) diagnosis, this acquired vasculitis has been reported with various clinical presentations including neurological symptoms. Herein we describe the case of a KD patient presenting with stroke. A 15-month-old boy was referred due to stroke that occurred on the fifth day of febrile illness. He was initially admitted to another hospital due to fever and diarrhea...
January 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28095491/pro-inflammatory-cytokine-levels-in-hiv-infected-and-uninfected-pregnant-women-with-and-without-preeclampsia
#3
Niren Ray Maharaj, Alisa Phulukdaree, Savania Nagiah, Prithiksha Ramkaran, Charlette Tiloke, Anil Amichund Chuturgoon
INTRODUCTION: Preeclampsia and HIV/AIDS are inflammatory conditions that contribute significantly to adverse maternal and foetal outcomes. The immune reconstitution effects of HAART on inflammatory mediators has not been adequately studied in pregnancy and may impact on the inflammatory cytokine network in women with co-morbid preeclampsia. Our study evaluated changes in pro-inflammatory cytokines IL-2, TNF-α, IFN-γ and IL-6 in HIV infected preeclamptic women on HAART. METHODS: A prospective experimental study was conducted at Prince Mshiyeni Memorial Hospital between July 2013 and September 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28094364/effect-of-electron-spectral-diffusion-on-static-dynamic-nuclear-polarization-at-7-tesla
#4
Alisa Leavesley, Daphna Shimon, Ting Ann Siaw, Akiva Feintuch, Daniella Goldfarb, Shimon Vega, Ilia Kaminker, Songi Han
Here, we present an integrated experimental and theoretical study of (1)H dynamic nuclear polarization (DNP) of a frozen aqueous glass containing free radicals at 7 T, under static conditions and at temperatures ranging between 4 and 20 K. The DNP studies were performed with a home-built 200 GHz quasi-optics microwave bridge, powered by a tunable solid-state diode source. DNP using monochromatic and continuous wave (cw) irradiation applied to the electron paramagnetic resonance (EPR) spectrum of the radicals induces the transfer of polarization from the electron spins to the surrounding nuclei of the solvent and solutes in the frozen aqueous glass...
January 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28089378/butyrate-production-under-aerobic-growth-conditions-by-engineered-escherichia-coli
#5
Naoya Kataoka, Alisa S Vangnai, Thunyarat Pongtharangkul, Toshiharu Yakushi, Kazunobu Matsushita
Butyrate is an important industrial platform chemical. Although several groups have reported butyrate production under oxygen-limited conditions by a native producer, Clostridium tyrobutylicum, and by a metabolically engineered Escherichia coli, efforts to produce butyrate under aerobic growth conditions have met limited success. Here, we constructed a novel butyrate synthetic pathway that functions under aerobic growth conditions in E. coli, by modifying the 1-butanol synthetic pathway reported previously...
January 11, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28087565/perturbation-of-retinoid-homeostasis-increases-malformation-risk-in-embryos-exposed-to-pregestational-diabetes
#6
Leo M Y Lee, Maran B W Leung, Rachel C Y Kwok, Yun-Chung Leung, Chi-Chiu Wang, Peter J McCaffery, Andrew J Copp, Alisa S W Shum
Pregestational diabetes is highly associated with increased risk of birth defects. However, factors that can increase or reduce expressivity and penetrance of malformations in diabetic pregnancies remain poorly identified. All-trans retinoic acid (RA) plays crucial roles in embryogenesis. Here, we find that Cyp26a1, which encodes a key enzyme for catabolic inactivation of RA required for tight control of local RA concentrations, is significantly down-regulated in embryos of diabetic mice. Embryonic tissues expressing Cyp26a1 show reduced efficiency of RA clearance...
January 13, 2017: Diabetes
https://www.readbyqxmd.com/read/28079442/buchbesprechungen
#7
Christian M Heidl, Alisa Hemberger
No abstract text is available yet for this article.
January 2017: Pflege
https://www.readbyqxmd.com/read/28071753/de-novo-assembly-annotation-and-characterization-of-the-whole-brain-transcriptome-of-male-and-female-syrian-hamsters
#8
Katharine E McCann, David M Sinkiewicz, Alisa Norvelle, Kim L Huhman
Hamsters are an ideal animal model for a variety of biomedical research areas such as cancer, virology, circadian rhythms, and behavioural neuroscience. The use of hamsters has declined, however, most likely due to the dearth of genetic tools available for these animals. Our laboratory uses hamsters to study acute social stress, and we are beginning to investigate the genetic mechanisms subserving defeat-induced behavioural change. We have been limited, however, by the lack of genetic resources available for hamsters...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28059985/effect-of-peer-to-peer-nurse-physician-collaboration-on-attitudes-toward-the-nurse-physician-relationship
#9
Pamela B Edwards, Jean B Rea, Marilyn H Oermann, Ellen J Hegarty, Judy R Prewitt, Mariah Rudd, Susan Silva, Alisa Nagler, David A Turner, Stephen D DeMeo
The goal of this study was to pilot a novel peer-to-peer nurse-physician collaboration program and assess for changes in attitudes toward collaboration among a group of newly licensed nurses and resident physicians (n = 39). The program included large group meetings, with discussion of key concepts related to interprofessional collaboration. In unit-based teams, the registered nurses and physicians developed a quality improvement project to meet a need on their unit. Creating learning activities like this program enable nursing professional development specialists to promote interprofessional collaboration and learning...
January 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28030435/feasibility-and-technique-for-transvaginal-natural-orifice-transluminal-endoscopic-surgery-liver-resection-a-porcine-model
#10
Toshio Katagiri, Yuichiro Otsuka, Santiago Horgan, Bryan J Sandler, Garth R Jacobsen, Alisa M Coker, Masaru Tsuchiya, Tetsuya Maeda, Hironori Kaneko
INTRODUCTION: Natural orifice transluminal endoscopic surgery (NOTES) is a challenging minimally invasive procedure. Although laparoscopic techniques for liver resection are gaining acceptance worldwide, few studies have investigated NOTES liver resection. We used a porcine model to assess the feasibility and safety of transvaginal NOTES liver resection (TV NOTES LR). MATERIALS AND METHODS: Nine female pigs underwent TV NOTES LR. A nonsurvival acute porcine model with general anesthesia was used in all cases...
December 26, 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28029346/practice-patterns-in-postoperative-echocardiographic-surveillance-after-congenital-heart-surgery-in-children-a-single-center-experience
#11
Alisa Arunamata, David M Axelrod, Alaina K Kipps, Doff B McElhinney, Andrew Y Shin, Frank L Hanley, Inger L Olson, Stephen J Roth, Elif Seda Selamet Tierney
OBJECTIVES: To review current institutional practice and describe factors contributing to variation in inpatient postoperative imaging surveillance after congenital heart surgery. STUDY DESIGN: We reviewed records of all children who underwent congenital heart surgery from June to December 2014. Number and primary indications for postoperative transthoracic echocardiograms (TTEs), providers involved, cardiovascular intensive care unit (CVICU) and total hospital length of stay, and Risk-Adjustment for Congenital Heart Surgery-1 scores were recorded...
October 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/28029127/organophosphorous-pesticide-detection-in-olive-oil-by-using-a-miniaturized-easy-to-use-and-cost-effective-biosensor-combined-with-quechers-for-sample-clean-up
#12
Fabiana Arduini, Matteo Forchielli, Viviana Scognamiglio, Kozitsina Alisa Nikolaevna, Danila Moscone
Herein, we report a portable electrochemical biosensor based on butyrylcholinesterase (BChE) immobilized on carbon black (CB)-modified screen-printed electrodes (SPEs) for the detection of organophosphorous pesticides in olive oil. The BChE/CB-SPE biosensor was developed to detect paraoxon in standard solutions as well as in olive oil samples previously treated with the QuEChERS method to extract pesticides from the whole fatty matrix. The biosensor shows a linear concentration range of between 20 and 100 ppb for paraoxon both in standard solutions (phosphate buffer 0...
December 24, 2016: Sensors
https://www.readbyqxmd.com/read/28027802/assessing-pesticide-wet-deposition-risk-within-a-small-agricultural-watershed-in-the-southeastern-coastal-plain-usa
#13
Thomas L Potter, Alisa W Coffin
Pesticide volatilization and deposition with precipitation is widely documented and has been connected to adverse ecological impact. Here we describe a 3-yr study of current use and legacy pesticides in event-based rain samples within a 123-ha agricultural watershed. Crops in farm fields were documented quarterly with data used to estimate target compound use. The median number of pesticide detections in samples was 6. The fungicide, chlorothalonil which was used most intensively was detected in nearly all samples...
December 24, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28024868/germline-mutations-in-palb2-brca1-and-rad51c-which-regulate-dna-recombination-repair-in-patients-with-gastric-cancer
#14
Ruta Sahasrabudhe, Paul Lott, Mabel Bohorquez, Ted Toal, Ana P Estrada, John J Suarez, Alejandro Brea-Fernández, José Cameselle-Teijeiro, Carla Pinto, Irma Ramos, Alejandra Mantilla, Rodrigo Prieto, Alejandro Corvalan, Enrique Norero, Carolina Alvarez, Teresa Tapia, Pilar Carvallo, Luz M Gonzalez, Alicia Cock-Rada, Angela Solano, Florencia Neffa, Adriana Della Valle, Chris Yau, Gabriela Soares, Alexander Borowsky, Nan Hu, Li-Ji He, Xiao-You Han, Philip R Taylor, Alisa M Goldstein, Javier Torres, Magdalena Echeverry, Clara Ruiz-Ponte, Manuel R Teixeira, Luis G Carvajal Carmona
Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. We then analyzed sequences of candidate genes in 333 independent HDGC and non-HDGC cases. We identified 11 cases with mutations in PALB2, BRCA1, or RAD51C genes, which regulate homologous DNA recombination...
December 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/28018998/fibrinolysis-in-patients-with-a-mild-to-moderate-bleeding-tendency-of-unknown-cause
#15
Johanna Gebhart, Sylvia Kepa, Stefanie Hofer, Silvia Koder, Alexandra Kaider, Alisa S Wolberg, Helmuth Haslacher, Peter Quehenberger, Ernst Eigenbauer, Simon Panzer, Christine Mannhalter, Ingrid Pabinger
In more than 50% of patients with a mild-to-moderate bleeding tendency, no underlying cause can be identified (bleeding of unknown cause, BUC). Data on parameters of fibrinolysis in BUC are scarce in the literature and reveal discrepant results. It was the aim of this study to investigate increased fibrinolysis as a possible mechanism of BUC. We included 270 patients (227 females, median age 44 years, 25-75(th) percentile 32-58) with BUC and 98 healthy controls (65 females, median age 47 years, 25-75(th)percentile 39-55)...
December 26, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/28000488/skeletal-maturity-assessment-using-mandibular-canine-calcification-stages
#16
Vildana Džemidžić, Alisa Tiro, Amila Zukanović, Ismeta Redžić, Enita Nakaš
OBJECTIVE: The aims of this study were: to investigate the relationship between mandibular canine calcification stages and skeletal maturity; and to evaluate whether the mandibular canine calcification stages may be used as a reliable diagnostic tool for skeletal maturity assessment. MATERIALS AND METHODS: This study included 151 subjects: 81 females and 70 males, with ages ranging from 9 to 16 years (mean age: 12.29±1.86 years). The inclusion criteria for subjects were as follows: age between 9 and 16 years; good general health without any hormonal, nutritional, growth or dental development problems...
November 2016: Acta Medica Academica
https://www.readbyqxmd.com/read/27983608/refractive-index-sensing-with-d-shaped-plastic-optical-fibers-for-chemical-and-biochemical-applications
#17
Filipa Sequeira, Daniel Duarte, Lúcia Bilro, Alisa Rudnitskaya, Maria Pesavento, Luigi Zeni, Nunzio Cennamo
We report the optimization of the length of a D-shaped plastic optical fiber (POF) sensor for refractive index (RI) sensing from a numerical and experimental point of view. The sensing principle is based on total internal reflection (TIR). POFs with 1 mm in diameter were embedded in grooves, realized in planar supports with different lengths, and polished to remove the cladding and part of the core. All D-shaped POF sensors were tested using aqueous medium with different refractive indices (from 1.332 to 1...
December 13, 2016: Sensors
https://www.readbyqxmd.com/read/27982709/assessing-youth-appealing-content-in-alcohol-advertisements-application-of-a-content-appealing-to-youth-cay-index
#18
Alisa A Padon, Rajiv N Rimal, William DeJong, Michael Siegel, David Jernigan
Underage drinking is a serious public health problem in the United States, and youth exposure to alcohol advertising has been indicated as a possible contributing factor. Although a number of studies have identified advertising content features that youth find appealing, a key limitation of this research is the absence of a broader tool to examine those features, especially those used by alcohol brands that are popular with underage drinkers. We created an index of content elements found in the research literature to be appealing to youth, and then used this index in a content analysis to identify the degree to which youth-appealing content appeared in a sample of alcohol ads that aired on television shows popular among youth...
December 16, 2016: Health Communication
https://www.readbyqxmd.com/read/27977500/violent-extremism-community-based-violence-prevention-and-mental-health-professionals
#19
Stevan M Weine, Andrew Stone, Aliya Saeed, Stephen Shanfield, John Beahrs, Alisa Gutman, Aida Mihajlovic
New community-based initiatives being developed to address violent extremism in the United States are utilizing mental health services and leadership. This article reviews current approaches to preventing violent extremism, the contribution that mental illness and psychosocial problems can make to violent extremism, and the rationale for integrating mental health strategies into preventing violent extremism. The authors describe a community-based targeted violence prevention model and the potential roles of mental health professionals...
January 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27958734/novel-irreversible-agonists-acting-at-the-a1-adenosine-receptor
#20
Manuela Jörg, Alisa Glukhova, Alaa Abdul-Ridha, Elizabeth A Vecchio, Anh T N Nguyen, Patrick M Sexton, Paul J White, Lauren T May, Arthur Christopoulos, Peter J Scammells
The A1 adenosine receptor (A1AR) is an important G protein-coupled receptor that regulates a range of physiological functions. Herein we report the discovery of novel irreversible agonists acting at the A1AR, which have the potential to serve as useful research tools for studying receptor structure and function. A series of novel adenosine derivatives bearing electrophilic substituents was synthesized, and four compounds, 8b, 15a, 15b, and 15d, were shown to possess similar potency and efficacy to the reference high efficacy agonist, NECA, in an assay of ERK1/2 phosphorylation assay...
December 22, 2016: Journal of Medicinal Chemistry
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