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https://www.readbyqxmd.com/read/28228446/fibrinogen-and-fibrin-in-hemostasis-and-thrombosis
#1
Sravya Kattula, James R Byrnes, Alisa S Wolberg
No abstract text is available yet for this article.
March 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28228171/quantification-of-multicellular-organization-junction-integrity-and-substrate-features-in-collective-cell-migration
#2
Adam C Canver, Alisa Morss Clyne
Quantitative analysis of multicellular organization, cell-cell junction integrity, and substrate properties is essential to understand the mechanisms underlying collective cell migration. However, spatially and temporally defining these properties is difficult within collectively migrating cell groups due to challenges in accurate cell segmentation within the monolayer. In this paper, we present Matlab®-based algorithms to spatially quantify multicellular organization (migration distance, interface roughness, and cell alignment, area, and morphology), cell-cell junction integrity, and substrate features in confocal microscopy images of two-dimensional collectively migrating endothelial monolayers...
February 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28222448/acute-effects-of-viral-exposure-on-p-glyco-protein-function-in-the-mouse-fetal-blood-brain-barrier
#3
Enrrico Bloise, Sophie Petropoulos, Majid Iqbal, Alisa Kostaki, Tania Maria Ortiga-Carvalho, William Gibb, Stephen G Matthews
BACKGROUND/AIMS: Viral infection during pregnancy is known to affect the fetal brain. The toll-like receptor (TLR)-3 is a pattern recognition receptor activated by viruses known to elicit adverse fetal neurological outcomes. The P-glycoprotein (P-gp) efflux transporter protects the developing fetus by limiting the transfer of substrates across both the placenta and the fetal blood-brain barrier (BBB). As such, inhibition of P-gp at these blood-barrier sites may result in increased exposure of the developing fetus to environmental toxins and xenobiotics present in the maternal circulation...
February 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28219114/self-reported-youth-and-adult-exposure-to-alcohol-marketing-in-traditional-and-digital-media-results-of-a-pilot-survey
#4
David H Jernigan, Alisa Padon, Craig Ross, Dina Borzekowski
BACKGROUND: Alcohol marketing is known to be a significant risk factor for underage drinking. However, little is known about youth and adult exposure to alcohol advertising in digital and social media. This study piloted a comparative assessment of youth and adult recall of exposure to online marketing of alcohol. METHODS: From September to October 2013, a pilot survey of past 30-day exposure to alcohol advertising and promotional content in traditional and digital media was administered to a national sample of 1,192 youth (ages 13 to 20) and 1,124 adults (ages ≥21) using a prerecruited Internet panel maintained by GfK Custom Research...
February 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28214644/plant-growth-promoting-candida-sp-avgb4-with-capability-of-4-nitroaniline-biodegradation-under-drought-stress
#5
Sivagnanam Silambarasan, Alisa S Vangnai
This study focused on rhizospheric yeast capable of degrading a priority pollutant, 4-nitroaniline (4-NA), under drought stress. Candida sp. AVGB4 (AVGB4) inhabiting in soil was isolated and characterized with plant-growth promoting (PGP) traits. 4-NA-dependent growth kinetic and biodegradation kinetics were analyzed and revealed 4-NA complete degradation and tolerance property. AVGB4 proliferation, PGP activities, and 4-NA degradation activity were well maintained under drought stress induced by PEG-6000 incorporation, and could be strengthened in the presence of succinate, an organic compound generally found in plant root exudates...
February 16, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28210021/opiate-analgesia-treatment-reduced-early-inflammatory-response-after-severe-chest-injuries
#6
Goran Krdzalic, Nermin Musanovic, Alisa Krdzalic, Indira Mehmedagic, Amar Kesetovic
BACKGROUND: The frequency of severe chest injuries are increased. Their high morbidity is followed by systemic inflammatory response. The efficacy of pharmacological blockade of the response could prevent complications after chest injures. AIM: The aim of the study was to show an inflammatory response level, its prognostic significant and length of hospital stay after chest injures opiate analgesia treatment. METHODS: Sixty patients from Department of Thoracic Surgery with severe chest injures were included in the prospective study...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28201972/cell-based-tolerogenic-therapy-experience-from-animal-models-of-multiple-sclerosis-type-1-diabetes-and-rheumatoid-arthritis
#7
Ivana Stojanović, Mirjana Dimitrijević, Marta Vives-Pi, Maria Jose Mansilla, Irma Pujol-Autonell, Silvia Rodríguez-Fernandez, Lenka Palová-Jelínková, David P Funda, Alisa Gruden-Movsesijan, Ljiljana Sofronić-Milosavljević, Catharien M U Hilkens, Eva Martínez-Cáceres, Djordje Miljković
Cell-based tolerogenic therapy is a promising approach for the treatment of autoimmune diseases and transplant rejection. Regulatory T cells and tolerogenic dendritic cells have been particularly explored in the treatment of various autoimmune disorders in experimental models of disease. Although some of these cells have already been tested in a limited number of clinical trials, there is still a need for preclinical research on tolerogenic cells in animal models of autoimmunity. This review will focus on the relevance of data obtained from studies in experimental animal models for the use of tolerogenic cell-based therapy in humans...
14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28193109/child-neurology-education-for-pediatric-residents
#8
Dara V F Albert, Anup D Patel, Maria Behnam-Terneus, Beatriz Cunill-De Sautu, Nicole Verbeck, Alisa McQueen, H Barrett Fromme, John D Mahan
The aim of this study was to evaluate whether the current state of child neurology education during pediatric residency provides adequate preparation for pediatric practice. A survey was sent to recent graduates from 3 pediatric residency programs to assess graduate experience, perceived level of competence, and desire for further education in child neurology. Responses from generalists versus subspecialists were compared. The response rate was 32%, half in general pediatric practice. Only 22% feel very confident in approaching patients with neurologic problems...
March 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28185752/features-to-consider-when-selecting-new-digital-radiology-systems
#9
Alisa Walz-Flannigan
No abstract text is available yet for this article.
February 6, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28181889/making-the-udl-framework-universal-implications-for-individuals-with-intellectual-disability
#10
Sean J Smith, K Alisa Lowrey
No abstract text is available yet for this article.
February 2017: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28181887/applying-the-universal-design-for-learning-framework-for-individuals-with-intellectual-disability-the-future-must-be-now
#11
Sean J Smith, K Alisa Lowrey
The current research in Universal Design for Learning (UDL) for students with intellectual disability (ID) is briefly summarized and considered in light of the national goals presented by the American Association on Intellectual and Developmental Disabilities (AAIDD) in this article. Additionally, an action plan is provided for researchers and practitioners to extend knowledge on the implementation of the UDL framework inclusive of individuals with ID.
February 2017: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28181886/udl-and-intellectual-disability-what-do-we-know-and-where-do-we-go
#12
Kavita Rao, Sean J Smith, K Alisa Lowrey
As an instructional design framework that can be used to design curriculum for students with and without disabilities, Universal Design for Learning (UDL) has the potential to support meaningful inclusion of students with intellectual disability (ID) in general educational settings. This article presents an overview of the existing set of research studies on UDL application for students with ID in PreK-12 settings. The current body of research illustrates that UDL is being applied to instructional activities for students with ID to examine a variety of interventions (e...
February 2017: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28181885/a-closer-look-examining-teachers-language-around-udl-inclusive-classrooms-and-intellectual-disability
#13
K Alisa Lowrey, Aleksandra Hollingshead, Kathy Howery
The purpose of this study was to examine the language teachers used to discuss inclusion, Universal Design for Learning (UDL), and learners with intellectual disability (ID) in an effort to better understand how teachers describe the relationship between those three. Utilizing a secondary analysis procedure, interview transcripts from seven general education teachers were reanalyzed to identify language used by teachers to refer to inclusive educational settings, the implementation of UDL, and learners with intellectual disability...
February 2017: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28165452/dek-targeting-dna-aptamers-as-therapeutics-for-inflammatory-arthritis
#14
Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, Carmelo Carmona-Rivera, M Asif Amin, Bradley J Rabquer, Marta J Gonzales-Hernandez, Julie Jorns, Smriti Mohan, Srilakshmi Yalavarthi, Dave A Pai, Kristine Angevine, Shelley J Almburg, Jason S Knight, Barbara S Adams, Alisa E Koch, David A Fox, David R Engelke, Mariana J Kaplan, David M Markovitz
Novel therapeutics are required for improving the management of chronic inflammatory diseases. Aptamers are single-stranded RNA or DNA molecules that have recently shown utility in a clinical setting, as they can specifically neutralize biomedically relevant proteins, particularly cell surface and extracellular proteins. The nuclear chromatin protein DEK is a secreted chemoattractant that is abundant in the synovia of patients with juvenile idiopathic arthritis (JIA). Here, we show that DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy...
February 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28152250/intravoxel-incoherent-motion-mri-in-the-brain-impact-of-the-fitting-model-on-perfusion-fraction-and-lesion-differentiability
#15
Vera C Keil, Burkhard Mädler, Gerrit H Gielen, Bogdan Pintea, Kanishka Hiththetiya, Alisa R Gaspranova, Jürgen Gieseke, Matthias Simon, Hans H Schild, Dariusch R Hadizadeh
PURPOSE: To investigate the effect of the choice of the curve-fitting model on the perfusion fraction (fIVIM ) with regard to tissue type characterization, correlation with microvascular anatomy, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters. Several curve-fitting models coexist in intravoxel incoherent motion (IVIM) MRI to derive the (fIVIM ). MATERIALS AND METHODS: In all, 29 patients with brain lesions (12 gliomas, 11 meningiomas, three metastases, two gliotic scars, one multiple sclerosis) underwent IVIM-MRI (32 b-values, 0 to 2000 s/mm(2) ) at 3T...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28152005/the-done-framework-creation-evaluation-and-updating-of-an-interdisciplinary-dynamic-framework-2-0-of-determinants-of-nutrition-and-eating
#16
F Marijn Stok, Stefan Hoffmann, Dorothee Volkert, Heiner Boeing, Regina Ensenauer, Marta Stelmach-Mardas, Eva Kiesswetter, Alisa Weber, Harald Rohm, Nanna Lien, Johannes Brug, Michelle Holdsworth, Britta Renner
The question of which factors drive human eating and nutrition is a key issue in many branches of science. We describe the creation, evaluation, and updating of an interdisciplinary, interactive, and evolving "framework 2.0" of Determinants Of Nutrition and Eating (DONE). The DONE framework was created by an interdisciplinary workgroup in a multiphase, multimethod process. Modifiability, relationship strength, and population-level effect of the determinants were rated to identify areas of priority for research and interventions...
2017: PloS One
https://www.readbyqxmd.com/read/28146470/rare-and-low-frequency-coding-variants-alter-human-adult-height
#17
Eirini Marouli, Mariaelisa Graff, Carolina Medina-Gomez, Ken Sin Lo, Andrew R Wood, Troels R Kjaer, Rebecca S Fine, Yingchang Lu, Claudia Schurmann, Heather M Highland, Sina Rüeger, Gudmar Thorleifsson, Anne E Justice, David Lamparter, Kathleen E Stirrups, Valérie Turcot, Kristin L Young, Thomas W Winkler, Tõnu Esko, Tugce Karaderi, Adam E Locke, Nicholas G D Masca, Maggie C Y Ng, Poorva Mudgal, Manuel A Rivas, Sailaja Vedantam, Anubha Mahajan, Xiuqing Guo, Goncalo Abecasis, Katja K Aben, Linda S Adair, Dewan S Alam, Eva Albrecht, Kristine H Allin, Matthew Allison, Philippe Amouyel, Emil V Appel, Dominique Arveiler, Folkert W Asselbergs, Paul L Auer, Beverley Balkau, Bernhard Banas, Lia E Bang, Marianne Benn, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Heiner Boeing, Eric Boerwinkle, Carsten A Böger, Lori L Bonnycastle, Jette Bork-Jensen, Michiel L Bots, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Gerome Breen, Murray H Brilliant, Linda Broer, Amber A Burt, Adam S Butterworth, David J Carey, Mark J Caulfield, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Massimiliano Cocca, Francis S Collins, James P Cook, Janie Corley, Jordi Corominas Galbany, Amanda J Cox, Gabriel Cuellar-Partida, John Danesh, Gail Davies, Paul I W de Bakker, Gert J de Borst, Simon de Denus, Mark C H de Groot, Renée de Mutsert, Ian J Deary, George Dedoussis, Ellen W Demerath, Anneke I den Hollander, Joe G Dennis, Emanuele Di Angelantonio, Fotios Drenos, Mengmeng Du, Alison M Dunning, Douglas F Easton, Tapani Ebeling, Todd L Edwards, Patrick T Ellinor, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Jessica D Faul, Mary F Feitosa, Shuang Feng, Ele Ferrannini, Marco M Ferrario, Jean Ferrieres, Jose C Florez, Ian Ford, Myriam Fornage, Paul W Franks, Ruth Frikke-Schmidt, Tessel E Galesloot, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Ayush Giri, Giorgia Girotto, Scott D Gordon, Penny Gordon-Larsen, Mathias Gorski, Niels Grarup, Megan L Grove, Vilmundur Gudnason, Stefan Gustafsson, Torben Hansen, Kathleen Mullan Harris, Tamara B Harris, Andrew T Hattersley, Caroline Hayward, Liang He, Iris M Heid, Kauko Heikkilä, Øyvind Helgeland, Jussi Hernesniemi, Alex W Hewitt, Lynne J Hocking, Mette Hollensted, Oddgeir L Holmen, G Kees Hovingh, Joanna M M Howson, Carel B Hoyng, Paul L Huang, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Jan-Håkan Jansson, Gail P Jarvik, Gorm B Jensen, Min A Jhun, Yucheng Jia, Xuejuan Jiang, Stefan Johansson, Marit E Jørgensen, Torben Jørgensen, Pekka Jousilahti, J Wouter Jukema, Bratati Kahali, René S Kahn, Mika Kähönen, Pia R Kamstrup, Stavroula Kanoni, Jaakko Kaprio, Maria Karaleftheri, Sharon L R Kardia, Fredrik Karpe, Frank Kee, Renske Keeman, Lambertus A Kiemeney, Hidetoshi Kitajima, Kirsten B Kluivers, Thomas Kocher, Pirjo Komulainen, Jukka Kontto, Jaspal S Kooner, Charles Kooperberg, Peter Kovacs, Jennifer Kriebel, Helena Kuivaniemi, Sébastien Küry, Johanna Kuusisto, Martina La Bianca, Markku Laakso, Timo A Lakka, Ethan M Lange, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Eric B Larson, I-Te Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Honghuang Lin, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Yeheng Liu, Yongmei Liu, Artitaya Lophatananon, Jian'an Luan, Steven A Lubitz, Leo-Pekka Lyytikäinen, David A Mackey, Pamela A F Madden, Alisa K Manning, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas G Martin, Angela L Mazul, Karina Meidtner, Andres Metspalu, Paul Mitchell, Karen L Mohlke, Dennis O Mook-Kanamori, Anna Morgan, Andrew D Morris, Andrew P Morris, Martina Müller-Nurasyid, Patricia B Munroe, Mike A Nalls, Matthias Nauck, Christopher P Nelson, Matt Neville, Sune F Nielsen, Kjell Nikus, Pål R Njølstad, Børge G Nordestgaard, Ioanna Ntalla, Jeffrey R O'Connel, Heikki Oksa, Loes M Olde Loohuis, Roel A Ophoff, Katharine R Owen, Chris J Packard, Sandosh Padmanabhan, Colin N A Palmer, Gerard Pasterkamp, Aniruddh P Patel, Alison Pattie, Oluf Pedersen, Peggy L Peissig, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John R B Perry, Thomas N Person, Ailith Pirie, Ozren Polasek, Danielle Posthuma, Olli T Raitakari, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Frida Renström, Paul M Ridker, John D Rioux, Neil Robertson, Antonietta Robino, Olov Rolandsson, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Kevin Sandow, Yadav Sapkota, Naveed Sattar, Marjanka K Schmidt, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Svati Shah, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S Small, Albert Vernon Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Valgerdur Steinthorsdottir, Heather M Stringham, Michael Stumvoll, Praveen Surendran, Leen M 't Hart, Katherine E Tansey, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Gerard Tromp, Stella Trompet, Emmanouil Tsafantakis, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Jonathan P Tyrer, Rudolf Uher, André G Uitterlinden, Sheila Ulivi, Sander W van der Laan, Andries R Van Der Leij, Cornelia M van Duijn, Natasja M van Schoor, Jessica van Setten, Anette Varbo, Tibor V Varga, Rohit Varma, Digna R Velez Edwards, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Diego Vozzi, Mark Walker, Feijie Wang, Carol A Wang, Shuai Wang, Yiqin Wang, Nicholas J Wareham, Helen R Warren, Jennifer Wessel, Sara M Willems, James G Wilson, Daniel R Witte, Michael O Woods, Ying Wu, Hanieh Yaghootkar, Jie Yao, Pang Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, Wei Zhao, He Zheng, Wei Zhou, Jerome I Rotter, Michael Boehnke, Sekar Kathiresan, Mark I McCarthy, Cristen J Willer, Kari Stefansson, Ingrid B Borecki, Dajiang J Liu, Kari E North, Nancy L Heard-Costa, Tune H Pers, Cecilia M Lindgren, Claus Oxvig, Zoltán Kutalik, Fernando Rivadeneira, Ruth J F Loos, Timothy M Frayling, Joel N Hirschhorn, Panos Deloukas, Guillaume Lettre
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors...
February 9, 2017: Nature
https://www.readbyqxmd.com/read/28143793/parent-and-provider-experience-and-shared-understanding-after-a-family-centered-nighttime-communication-intervention
#18
Alisa Khan, Jennifer Baird, Jayne E Rogers, Stephannie L Furtak, Kathryn A Williams, Brenda Allair, Katherine P Litterer, Meesha Sharma, Alla Smith, Mark A Schuster, Christopher P Landrigan
OBJECTIVE: To assess parent and provider experience and shared understanding after a family-centered, multidisciplinary nighttime communication intervention (nurse-physician brief, family huddle, family update sheet). METHODS: Prospective intervention study at a children's hospital from 5/2013-10/2013 (pre-intervention) and 5/2014-10/2014 (post-intervention). Participants included 464 parents, 176 nurses, and 52 resident-physicians of 582 hospitalized 0-17-year-old patients...
January 28, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28125554/o-006-rapid-infliximab-infusion-in-children-with-inflammatory-bowel-disease-a-multi-center-north-american-experience
#19
Wael El-Matary, Charles Samson, Alisa Crim, Sabina Ali, Andrew Grossman
BACKGROUND: Infusions of infliximab (IFX), a chimeric monoclonal antibody against tumor necrosis factor alpha (TNF-α) used to treat inflammatory bowel disease (IBD), can lead to development of anti-IFX antibodies (ATI), increasing risk of subsequent infusion reactions (IRs). IRs have been reported in as many as 5% of infusions and up to 10% to 20% of patients. The safety of rapid IFX infusion has been under-evaluated in children. In a multi-center study, the incidence of IRs associated with rapid infusion of IFX was examined...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28122276/role-of-plant-growth-promoting-ochrobactrum-sp-mc22-on-triclocarban-degradation-and-toxicity-mitigation-to-legume-plants
#20
Merry Krisdawati Sipahutar, Alisa S Vangnai
Triclocarban (TCC) is an emerging and persistent pollutant once released into environment. In this study, TCC-degrading Ochrobactrum sp. MC22, was isolated and characterized. This is the first report on plant-growth promoting bacterium with versatile capability of TCC degradation under aerobic and anaerobic conditions. The aerobic degradation of TCC occurred completely of which the kinetic analysis revealed a non-self-inhibitive substrate effect, and broad-concentration-range degradation efficiency (ranging from 0...
January 16, 2017: Journal of Hazardous Materials
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