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https://www.readbyqxmd.com/read/28639824/upside-down-perceived-space-affects-object-based-attention
#1
Frank Papenmeier, Hauke S Meyerhoff, Alisa Brockhoff, Georg Jahn, Markus Huff
Object-based attention influences the subjective metrics of surrounding space. However, does perceived space influence object-based attention, as well? We used an attentive tracking task that required sustained object-based attention while objects moved within a tracking space. We manipulated perceived space through the availability of depth cues and varied the orientation of the tracking space. When rich depth cues were available (appearance of a voluminous tracking space), the upside-down orientation of the tracking space (objects appeared to move high on a ceiling) caused a pronounced impairment of tracking performance compared with an upright orientation of the tracking space (objects appeared to move on a floor plane)...
July 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28636944/transduction-of-repetitive-mechanical-stimuli-by-piezo1-and-piezo2-ion-channels
#2
Amanda H Lewis, Alisa F Cui, Malcolm F McDonald, Jörg Grandl
Several cell types experience repetitive mechanical stimuli, including vein endothelial cells during pulsating blood flow, inner ear hair cells upon sound exposure, and skin cells and their innervating dorsal root ganglion (DRG) neurons when sweeping across a textured surface or touching a vibrating object. While mechanosensitive Piezo ion channels have been clearly implicated in sensing static touch, their roles in transducing repetitive stimulations are less clear. Here, we perform electrophysiological recordings of heterologously expressed mouse Piezo1 and Piezo2 responding to repetitive mechanical stimulations...
June 20, 2017: Cell Reports
https://www.readbyqxmd.com/read/28636714/characteristics-and-alternative-treatment-outcomes-of-antimalarial-refractory-cutaneous-lupus-erythematosus
#3
Renee Fruchter, Drew J B Kurtzman, Mital Patel, Joseph Merola, Andrew G Franks, Ruth Ann Vleugels, Alisa N Femia
No abstract text is available yet for this article.
June 21, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28630947/evolution-of-geographic-atrophy-in-participants-treated-with-ranibizumab-for-neovascular-age-related-macular-degeneration
#4
Alisa T Thavikulwat, Naima Jacobs-El, Jane S Kim, Elvira Agrón, Jesia Hasan, Catherine B Meyerle, David Valent, Catherine A Cukras, Henry E Wiley, Wai T Wong, Emily Y Chew
PURPOSE: To evaluate the risk factors, incidence, and rate of progression of geographic atrophy (GA) in eyes with neovascular age-related macular degeneration (nAMD) treated with ranibizumab. DESIGN: Post-hoc analysis of a prospective clinical study. PARTICIPANTS: 69 participants with nAMD in at least one eye. METHODS: Participants were prospectively treated in the study eye with 0.5 mg intravitreal ranibizumab. Study eyes received 4 monthly injections followed by pro re nata injections until a fluid-free macula was achieved on optical coherence tomography...
January 2017: Ophthalmology retina
https://www.readbyqxmd.com/read/28616700/evaluation-of-irradiation-effects-of-near-infrared-free-electron-laser-of-silver-alloy-for-dental-application
#5
Takao Kuwada-Kusunose, Alisa Kusunose, Masanobu Wakami, Chikako Takebayashi, Haruhiko Goto, Masahiro Aida, Takeshi Sakai, Keisuke Nakao, Kyoko Nogami, Manabu Inagaki, Ken Hayakawa, Kunihiro Suzuki, Toshiro Sakae
In the application of lasers in dentistry, there is a delicate balance between the benefits gained from laser treatment and the heat-related damage arising from laser irradiation. Hence, it is necessary to understand the different processes associated with the irradiation of lasers on dental materials. To obtain insight for the development of a safe and general-purpose laser for dentistry, the present study examines the physical effects associated with the irradiation of a near-infrared free-electron laser (FEL) on the surface of a commonly used silver dental alloy...
June 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28615206/plasticity-and-epitope-exposure-of-the-hiv-1-envelope-trimer
#6
Rebecca L R Powell, Maxim Totrov, Vincenza Itri, Xiaomei Liu, Alisa Fox, Susan Zolla-Pazner
We recently showed that mutations in the HIV-1 Envelope (Env) destabilize the V3 loop, rendering neutralization-resistant viruses sensitive to V3-directed monoclonal antibodies (mAbs). Here we investigated the propagation of this effect on other Env epitopes, with special emphasis on V2 loop exposure. Wildtype JR-FL and 19 mutant JR-FL pseudoviruses were tested for neutralization sensitivity to 21 mAbs specific for epitopes in V2, the CD4 binding site (CD4bs), and the CD4-induced (CD4i) region. Certain glycan mutants, mutations in the gp120 hydrophobic core, and mutations in residues involved in intra-protomer interactions exposed epitopes in the V2i region (overlays the α4β7 integrin binding site) and the V3 crown, suggesting a general destabilization of the distal region of the trimer apex...
June 14, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28610121/a-new-species-of-velvet-skate-i-notoraja-i-i-sereti-i-n-sp-rajiformes-arhynchobatidae-from-papua-new-guinea
#7
William T White, Peter R Last, Ralph R Mana
A new arhynchobatin skate, Notoraja sereti n. sp., is described based on three specimens collected from off Madang (Papua New Guinea) at depths of 800-980 m. This medium-size Notoraja skate shares with other velcro skates from the Western Pacific, N. alisae, N. fijiensis, N. inusitata and N. longiventralis, a ventral surface covering of fine denticles giving the skin a velvety feel. Notoraja sereti differs from all of these species in having a shorter snout (preorbital length 10.1-11.1 vs. 11.5-14.5% TL, prenasal length 8...
March 19, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609530/cognitive-function-after-testosterone-treatment
#8
LETTER
Susan M Resnick, Alvin M Matsumoto, Alisa J Stephens-Shields
No abstract text is available yet for this article.
June 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28607334/interhospital-transfer-of-critically-ill-patients
#9
Thomas Kiss, Alisa Bölke, Peter M Spieth
Transportation of a patient between medical facilities without interruption of the medical treatment can be a challenging task. This review aims to define the term "interhospital transport" and give a general overview of the steps for organizing a transfer. Furthermore we discuss the team qualification, equipment standards and how to manage adverse events before and during transport by means of patient triage. The advanced interhospital transport of the critically ill patient can be defined as follows: "transportation of a patient between medical facilities without interruption of the medical treatment and monitoring due to the underlying disease by means of specific medical, technical equipment and knowledge with the objective of improved patient care"...
June 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28604684/sensory-integration-and-neuromodulatory-feedback-facilitate-drosophila-mechanonociceptive-behavior
#10
Chun Hu, Meike Petersen, Nina Hoyer, Bettina Spitzweck, Federico Tenedini, Denan Wang, Alisa Gruschka, Lara S Burchardt, Emanuela Szpotowicz, Michaela Schweizer, Ananya R Guntur, Chung-Hui Yang, Peter Soba
Nociception is an evolutionarily conserved mechanism to encode and process harmful environmental stimuli. Like most animals, Drosophila melanogaster larvae respond to a variety of nociceptive stimuli, including noxious touch and temperature, with stereotyped escape responses through activation of multimodal nociceptors. How behavioral responses to these different modalities are processed and integrated by the downstream network remains poorly understood. By combining trans-synaptic labeling, ultrastructural analysis, calcium imaging, optogenetics and behavioral analyses, we uncovered a circuit specific for mechanonociception but not thermonociception...
June 12, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28600875/plant-elicitor-peptides-promote-plant-defenses-against-nematodes-in-soybean
#11
Min Woo Lee, Alisa Huffaker, Devany Crippen, Robert T Robbins, Fiona Goggin
Plant elicitor peptides (Peps) are widely distributed among angiosperms, and have been shown to amplify immune responses in multiple plant families. Here we characterize three Peps from soybean (Glycine max) and describe their effects on plant defenses against two damaging agricultural pests, the root-knot nematode (Meloidogyne incognita) and the soybean cyst nematode (Heterodera glycines). Seed treatments with exogenous GmPep1, GmPep2, or GmPep3 significantly reduced the reproduction of both nematodes. Pep treatment also protected plants from the inhibitory effects of root-knot nematodes on aboveground growth, and upregulated basal expression levels of nematode-responsive defense genes...
June 10, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28594977/association-of-glaucoma-related-optical-coherence-tomography-measured-macular-damage-with-vision-related-quality-of-life
#12
Alisa J Prager, Donald C Hood, Jeffrey M Liebmann, C Gustavo De Moraes, Lama A Al-Aswad, Qi Yu, George A Cioffi, Dana M Blumberg
Importance: Little is known about the association between structural macular damage and self-reported visual function of people with glaucoma. Objective: To determine the association between vision-related quality of life among patients with primary open-angle glaucoma with structural macular retinal ganglion cell plus inner plexiform layer (RGC+IPL) loss identified by spectral-domain optical coherence tomography (SD-OCT) machine-generated deviation maps and thickness measurements...
June 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28582948/the-big-sell-managing-stigma-and-workplace-discrimination-following-moderate-to-severe-brain-injury
#13
Mary Stergiou-Kita, Alisa Grigorovich, Thecla Damianakis, Guylaine Le Dorze, Christine David, Carolyn Lemsky, Debbie Hebert
BACKGROUND: Misperceptions regarding persons with brain injuries (PWBI) can lead to stigmatization, workplace discrimination and, in turn, influence PWBIs full vocational integration. OBJECTIVE: In this study we explored how stigma may influence return-to-work processes, experiences of stigma and discrimination at the workplace for persons with (moderate to severe) brain injuries, and strategies that can be employed to manage disclosure. METHODS: Exploratory qualitative study; used in-depth interviews and an inductive thematic analytical approach in data analysis...
June 1, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28581887/impact-of-s-sulfocysteine-on-fragments-and-trisulfide-bond-linkages-in-monoclonal-antibodies
#14
Ronja Seibel, Sandra Maier, Alisa Schnellbaecher, Susanne Bohl, Maria Wehsling, Anne Zeck, Aline Zimmer
The quality of recombinant proteins such as monoclonal antibodies produced using Chinese hamster ovary cell-based mammalian systems is dependent on many factors, including cell line, process and cell culture media. Due to these factors, the generated product is heterogeneous and may have chemically-induced modifications or post-translational modifications that affect antibody stability, functionality and, in some cases, patient safety. This study demonstrates that S-sulfocysteine, a cysteine derivative, can increase the antibody specific productivity in different cell lines cultivated with different processes while minimizing trisulfide linkages in generated mAbs, mainly between heavy and light chain...
June 5, 2017: MAbs
https://www.readbyqxmd.com/read/28573899/exploring-the-feasibility-of-incorporating-sexual-education-into-routine-adolescent-office-visits
#15
Holly A Rankin, Alisa LoSasso, Beth I Schwartz
No abstract text is available yet for this article.
June 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28569009/myeloid-sarcoma-identified-on-liquid-based-cervical-cytology-samples-a-report-of-two-cases
#16
Jessica S Snider, Yekaterina Eichel, Alisa M Caudell, Olga S Chajewski, Jack Yang, Kathryn G Lindsey
The purpose of the Papanicolaou (Pap) smear is to detect primary squamous lesions of the uterine cervix. Although most successful at detection of squamous lesions, the Pap may also detect metastatic carcinomas, sarcomas, and melanomas. We report two rare cases of myeloid sarcoma (MS) of the uterine cervix identified on screening Pap smears with concurrent confirmatory cervical biopsies. The purpose of our study is to identify and report cytologic features of MS on Pap smears utilizing a liquid-based ThinPrep method, which has not been previously documented in literature...
May 31, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28567505/perspectives-on-medical-education-special-edition-lessons-learned-from-health-professions-education-scholarship-failures-surprises
#17
EDITORIAL
Lara Varpio, Alisa Nagler
No abstract text is available yet for this article.
June 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/28556790/dna-methylation-profiling-of-human-prefrontal-cortex-neurons-in-heroin-users-shows-significant-difference-between-genomic-contexts-of-hyper-and-hypomethylation-and-a-younger-epigenetic-age
#18
Alexey Kozlenkov, Andrew E Jaffe, Alisa Timashpolsky, Pasha Apontes, Sergei Rudchenko, Mihaela Barbu, William Byne, Yasmin L Hurd, Steve Horvath, Stella Dracheva
We employed Illumina 450 K Infinium microarrays to profile DNA methylation (DNAm) in neuronal nuclei separated by fluorescence-activated sorting from the postmortem orbitofrontal cortex (OFC) of heroin users who died from heroin overdose (N = 37), suicide completers (N = 22) with no evidence of heroin use and from control subjects who did not abuse illicit drugs and died of non-suicide causes (N = 28). We identified 1298 differentially methylated CpG sites (DMSs) between heroin users and controls, and 454 DMSs between suicide completers and controls (p < 0...
May 30, 2017: Genes
https://www.readbyqxmd.com/read/28552196/whole-genome-sequencing-coupled-to-imputation-discovers-genetic-signals-for-anthropometric-traits
#19
Ioanna Tachmazidou, Dániel Süveges, Josine L Min, Graham R S Ritchie, Julia Steinberg, Klaudia Walter, Valentina Iotchkova, Jeremy Schwartzentruber, Jie Huang, Yasin Memari, Shane McCarthy, Andrew A Crawford, Cristina Bombieri, Massimiliano Cocca, Aliki-Eleni Farmaki, Tom R Gaunt, Pekka Jousilahti, Marjolein N Kooijman, Benjamin Lehne, Giovanni Malerba, Satu Männistö, Angela Matchan, Carolina Medina-Gomez, Sarah J Metrustry, Abhishek Nag, Ioanna Ntalla, Lavinia Paternoster, Nigel W Rayner, Cinzia Sala, William R Scott, Hashem A Shihab, Lorraine Southam, Beate St Pourcain, Michela Traglia, Katerina Trajanoska, Gialuigi Zaza, Weihua Zhang, María S Artigas, Narinder Bansal, Marianne Benn, Zhongsheng Chen, Petr Danecek, Wei-Yu Lin, Adam Locke, Jian'an Luan, Alisa K Manning, Antonella Mulas, Carlo Sidore, Anne Tybjaerg-Hansen, Anette Varbo, Magdalena Zoledziewska, Chris Finan, Konstantinos Hatzikotoulas, Audrey E Hendricks, John P Kemp, Alireza Moayyeri, Kalliope Panoutsopoulou, Michal Szpak, Scott G Wilson, Michael Boehnke, Francesco Cucca, Emanuele Di Angelantonio, Claudia Langenberg, Cecilia Lindgren, Mark I McCarthy, Andrew P Morris, Børge G Nordestgaard, Robert A Scott, Martin D Tobin, Nicholas J Wareham, Paul Burton, John C Chambers, George Davey Smith, George Dedoussis, Janine F Felix, Oscar H Franco, Giovanni Gambaro, Paolo Gasparini, Christopher J Hammond, Albert Hofman, Vincent W V Jaddoe, Marcus Kleber, Jaspal S Kooner, Markus Perola, Caroline Relton, Susan M Ring, Fernando Rivadeneira, Veikko Salomaa, Timothy D Spector, Oliver Stegle, Daniela Toniolo, André G Uitterlinden, Inês Barroso, Celia M T Greenwood, John R B Perry, Brian R Walker, Adam S Butterworth, Yali Xue, Richard Durbin, Kerrin S Small, Nicole Soranzo, Nicholas J Timpson, Eleftheria Zeggini
Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole-genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of 12 anthropometric traits associated with height, body mass, and fat distribution in up to 267,616 individuals. We report 106 genome-wide significant signals that have not been previously identified, including 9 low-frequency variants pointing to functional candidates...
June 1, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28550991/production-of-1-3-diols-in-escherichia-coli
#20
Naoya Kataoka, Alisa S Vangnai, Thunyarat Pongtharangkul, Toshiharu Yakushi, Kazunobu Matsushita
To expand the diversity of chemical compounds produced through microbial conversion, a platform pathway for the production of widely used industrial chemicals, 1,3-diols, was engineered in Escherichia coli. The pathway was designed by modifying the previously reported (R)-1,3-butanediol synthetic pathway to consist of pct (propionate CoA-transferase) from Megasphaera elsdenii, bktB (thiolase), phaB (NADPH-dependent acetoacetyl-CoA reductase) from Ralstonia eutropha, bld (butyraldehyde dehydrogenase) from Clostridium saccharoperbutylacetonicum, and the endogenous alcohol dehydrogenase(s) of E...
May 18, 2017: Bioresource Technology
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