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Rebecca D Blanchard, Stephen DeMeo, Alisa Nagler
No abstract text is available yet for this article.
October 4, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Kristin W Samuelson, Alisa Bartel, Racquel Valadez, Joshua T Jordan
Objective: Posttraumatic stress disorder (PTSD) is associated with mild neurocognitive deficits, yet clients often complain of cognitive problems that exceed what their objective performance demonstrates. In addition, PTSD is associated with negative appraisals about the self, traumatic event, and one's ability to cope. This study examined posttraumatic cognitions as a moderator, and trauma coping self-efficacy as a mediator, of the relationship between PTSD symptoms and self-report of cognitive problems. Method: A sample of 268 trauma-exposed adults completed the PTSD Checklist for DSM-5, the Posttraumatic Cognitions Inventory, the Trauma Coping Self-Efficacy Scale, the Cognitive Self-Report Questionnaire, and the Quality of Life Scale...
October 13, 2016: Psychological Trauma: Theory, Research, Practice and Policy
Magnolia Bostick, Nathalie Bolduc, Alisa Lehman, Andrew Farmer
Next-generation sequencing is empowering a deeper understanding of biology by enabling RNA expression analysis over the entire transcriptome with high sensitivity and a wide dynamic range. One powerful application within this field is stranded RNA sequencing (RNA-seq), which is necessary to distinguish overlapping genes and to conduct comprehensive annotation and quantification of long non-coding RNAs. Commonly used methods for generating strand-specific RNA-seq libraries are often complicated by protocols that require several rounds of enzymatic treatments and clean-up steps, making them time-intensive, insensitive, and unsuitable for processing several samples simultaneously...
October 10, 2016: Current Protocols in Molecular Biology
Rachel N Fish, Magnolia Bostick, Alisa Lehman, Andrew Farmer
RNA sequencing (RNA-seq) is a powerful method for analyzing cell state, with minimal bias, and has broad applications within the biological sciences. However, transcriptome analysis of seemingly homogenous cell populations may in fact overlook significant heterogeneity that can be uncovered at the single-cell level. The ultra-low amount of RNA contained in a single cell requires extraordinarily sensitive and reproducible transcriptome analysis methods. As next-generation sequencing (NGS) technologies mature, transcriptome profiling by RNA-seq is increasingly being used to decipher the molecular signature of individual cells...
October 10, 2016: Current Protocols in Molecular Biology
Nathalie Bolduc, Alisa P Lehman, Andrew Farmer
Chromatin immunoprecipitation (ChIP) followed by high-throughput sequencing (ChIP-seq) has become the gold standard for mapping of transcription factors and histone modifications throughout the genome. However, for ChIP experiments involving few cells or targeting low-abundance transcription factors, the small amount of DNA recovered makes ligation of adapters very challenging. In this unit, we describe a ChIP-seq workflow that can be applied to small cell numbers, including a robust single-tube and ligation-free method for preparation of sequencing libraries from sub-nanogram amounts of ChIP DNA...
October 10, 2016: Current Protocols in Molecular Biology
Megan S C Lim, Cassandra J C Wright, Elise R Carrotte, Alisa E Pedrana
Issue addressed: Social networking sites (SNS) are increasingly popular platforms for health promotion. Advancements in SNS health promotion require quality evidence; however, interventions are often not formally evaluated. This study aims to describe evaluation practices used in SNS health promotion.Methods: A systematic review was undertaken of Medline, PsycINFO, Scopus, EMBASE, CINAHL Plus, Communication and Mass Media Complete, and Cochrane Library databases. Articles published between 2006 and 2013 describing any health promotion intervention delivered using SNS were included...
October 6, 2016: Health Promotion Journal of Australia
Alisa N Almas, Kathryn A Degnan, Charles A Nelson, Charles H Zeanah, Nathan A Fox
Young children removed from institutions and placed into foster care or adoptive homes have been shown to experience significant gains in IQ relative to children who remain in institutions. Less is known about the long-term impact of severe early deprivation on development in late childhood. Data are presented from a follow-up of children at 12 years of age in the Bucharest Early Intervention Project, a randomized clinical trial of foster care for institutionally reared children. Of the original 136 children in the study, 107 were tested with the Wechsler Intelligence Scale for Children-IV...
October 6, 2016: Developmental Psychology
Katerina Medjanik, Alisa Chernenkaya, Xeniya Kozina, Sergej A Nepijko, Gunnar Öhrwall, Pascale Foury-Leylekian, Pere Alemany, Gerd Schönhense, Enric Canadell, Jean-Paul Pouget
We present high-resolution near-edge X-ray absorption fine structure (NEXAFS) measurements at the P L2/3-edges, F K-edge, C K-edge and Se M2/3-edges of the quasi-one-dimensional (1D) conductor and superconductor (TMTSF)2PF6. NEXAFS allows probing the donor and acceptor moieties separately; spectra were recorded between room temperature (RT) and 30 K at normal incidence. Spectra taken around RT were also studied as a function of the angle () between the electric field of the X-ray beam and the 1D conducting direction...
October 5, 2016: Journal of Physical Chemistry. A
Alisa Nagler, Deborah L Engle, Mariah Rudd, Saumil M Chudgar, John L Weinerth, Catherine M Kuhn, Edward Buckley, Colleen O'Connor Grochowski
BACKGROUND: There is a paucity of information regarding institutional targets for the number of undergraduate medical education (UME) graduates being matched to graduate medical education (GME) programs at their home institutions. At our institution, the Duke University, the number of UME graduates matched to GME programs declined dramatically in 2011. To better understand why this decline may have happened, we sought to identify perceived quality metrics for UME and GME learners, evaluate trends in match outcomes and educational program characteristics, and explore whether there is an ideal retention rate for UME graduates in their home institutions' GME programs...
2016: Medical Education Online
Alisa A Sharova
The most international dosing guidelines on the use of botulinum toxin type A (BTXA) drugs support a 1:1 dose relationship between OnaBTXA and IncoBTXA and 1:2.5 between OnaBTXA and AboBTXA. However, different facial zones demonstrate different doses conversion ratios. The comparative analysis of nine consensuses on the use of Abo-, Ona-, and IncoBTXA in the United States, Russia, and Europe has been performed. We conducted a review of publications adopting the key words "botulinum toxin consensus," "botulinum toxin guideline...
October 3, 2016: Journal of Cosmetic Dermatology
Alisa P Domnina, Polina V Novikova, Olga G Lyublinskaya, Valeriy V Zenin, Irina I Fridlyanskaya, Vyacheslav M Mikhailov, Nikolay N Nikolsky
Stem cell transplantation, which is based on the application of mesenchymal stem/stromal cells (MSCs), is a rapidly developing approach to the regenerative therapy of various degenerative disorders characterized by brain and heart failure, as well as skin lesions. In comparison, the use of stem cell transplantations to treat infertility has received less attention. One of the causes of miscarriages and fetal growth delay is the loss of the decidual reaction of endometrial cells. The present study modeled decidualization processes in pseudopregnant rats...
October 2016: Experimental and Therapeutic Medicine
Zhewang Lin, Min Dong, Yugang Zhang, Eunyoung Alisa Lee, Hening Lin
Diphthamide and the tRNA wobble uridine modifications both require diphthamide biosynthesis 3 (Dph3) protein as an electron donor for the iron-sulfur clusters in their biosynthetic enzymes. Here, using a proteomic approach, we identified Saccharomyces cerevisiae cytochrome b5 reductase (Cbr1) as a NADH-dependent reductase for Dph3. The NADH- and Cbr1-dependent reduction of Dph3 may provide a regulatory linkage between cellular metabolic state and protein translation.
October 3, 2016: Nature Chemical Biology
Renee Fruchter, Drew J B Kurtzman, Daniel R Mazori, Natalie A Wright, Mital Patel, Ruth Ann Vleugels, Alisa N Femia
No abstract text is available yet for this article.
September 28, 2016: Journal of the American Academy of Dermatology
Catherine Tsangaris, Vanessa Moschino, Evangelia Strogyloudi, Valentina Coatu, Andreja Ramšak, Rana Abu Alhaija, Susana Carvalho, Serena Felline, Alisa Kosyan, Yiota Lazarou, Ioannis Hatzianestis, Andra Oros, Daniela Tiganus
No abstract text is available yet for this article.
September 29, 2016: Environmental Science and Pollution Research International
Edward Litton, Stuart Baker, Wendy N Erber, Shannon Farmer, Janet Ferrier, Craig French, Joel Gummer, David Hawkins, Alisa Higgins, Axel Hofmann, Bart De Keulenaer, Julie McMorrow, John K Olynyk, Toby Richards, Simon Towler, Robert Trengove, Steve Webb
PURPOSE: Both anaemia and allogenic red blood cell transfusion are common and potentially harmful in patients admitted to the intensive care unit. Whilst intravenous iron may decrease anaemia and RBC transfusion requirement, the safety and efficacy of administering iron intravenously to critically ill patients is uncertain. METHODS: The multicentre, randomized, placebo-controlled, blinded Intravenous Iron or Placebo for Anaemia in Intensive Care (IRONMAN) study was designed to test the hypothesis that, in anaemic critically ill patients admitted to the intensive care unit, early administration of intravenous iron, compared with placebo, reduces allogeneic red blood cell transfusion during hospital stay and increases the haemoglobin level at the time of hospital discharge...
September 30, 2016: Intensive Care Medicine
Mary-Margaret A Fill, David Sweat, Helen Morrow, Alisa Haushalter, Judy C Martin, Tyler Zerwekh, Tamal Chakraverty, Jennifer Kmet, Kevin Morris, Kelly Moore, Marion Kainer, Rendi Murphree, John R Dunn, William Schaffner, Timothy F Jones
On April 15, 2016, local public health officials in Shelby County, Tennessee, were notified of a positive measles immunoglobulin M (IgM) test for a male aged 18 months (patient A). On April 18, 2016, a second positive measles IgM test was reported for a man aged 50 years (patient B). Both patients had rash onset on April 9, 2016. The Shelby County Health Department initiated an investigation, and confirmatory testing for measles virus on oropharyngeal swabs by polymerase chain reaction (PCR) at CDC was positive for both patients...
2016: MMWR. Morbidity and Mortality Weekly Report
Angelica Marsberg, Martin Kemler, Fahimeh Jami, Jan H Nagel, Alisa Postma-Smidt, Sanushka Naidoo, Michael J Wingfield, Pedro W Crous, Joseph Spatafora, Cedar N Hesse, Barbara Robbertse, Bernard Slippers
: Botryosphaeria dothidea is the type species of Botryosphaeria (Botryosphaeriaceae, Botryosphaeriales). Fungi residing in this order are amongst the most widespread and important canker and dieback pathogens of trees worldwide, with B. dothidea one of the most common species on a large number of hosts. Its taxonomic circumscription has undergone substantial change in the past decade, making it difficult to interpret the large volume of literature linked to the name B. dothidea. This pathogen profile synthesises the current understanding of B...
September 28, 2016: Molecular Plant Pathology
Luba Dumenco, Deborah L Engle, Kristen Goodell, Alisa Nagler, Robin K Ovitsh, Shari A Whicker
After participating in a group peer-review exercise at a workshop presented by Academic Medicine and MedEdPORTAL editors at the 2015 Association of American Medical Colleges Medical Education Meeting, the authors realized that the way their work group reviewed a manuscript was very different from the way by which they each would have reviewed the paper as an individual. Further, the group peer-review process yielded more robust feedback for the manuscript's authors than did the traditional individual peer-review process...
September 27, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Alisa A Padon, Rajiv N Rimal, David Jernigan, Michael Siegel, William DeJong
Social norms affect human behavior, and underage drinking is no exception. Using the theory of normative social behavior, this study tested the proposition that the association between perceptions about the prevalence of drinking (descriptive norms) and underage drinking is strengthened when perceived pressures to conform (injunctive norms) and beliefs about the benefits of drinking (outcome expectations) are high. This proposition was tested on a nationally representative sample of underage drinkers ages 13-20 (N = 1,031) in relation to their alcohol consumption, expanding on research with college-age youth...
October 2016: Journal of Health Communication
Erica Frank, Kate Tairyan, Michelle Everton, Jennifer Chu, Craig Goolsby, Alisa Hayes, Ann Hulton
BACKGROUND: The WHO has called for the use of computer-aided education to train millions of additional health providers. We herein address this appeal with the first globally available, free, accredited, computer-aided, and peer and mentor-guided course. METHODS: The intervention studied was's first course, "Emergency Medicine (EM) for Senior Medical Students", required for the graduating Classes of 2013 at the University of Missouri (UM) and the U...
September 20, 2016: Healthcare
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