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https://www.readbyqxmd.com/read/27858518/three-united-laparoscopic-surgery-for-the-treatment-of-gastric-cardia-cancer-a-comparative-study-with-laparotomy-and-laparoscopy-assisted-surgery
#1
Zhanxue Zhang, Shuyuan Sun, Jinchun Qi, Shaofan Qiu, Haijun Wang, Lina Ru, Lin Lin, Zhong Li, Zongmao Zhao
BACKGROUND & AIM: Gastric cancer is a leading cause of cancer-related mortality worldwide. We have invented a novel hand-assist device that allows the placement of surgical instruments and the maneuvering of the surgeon's hand, and we have established a new hand-assisted laparoscopic technique called Three United Laparoscopic Surgery (TULS) for laparoscopic dissection of advanced gastric cancer. The present study aimed at exploring the usefulness of TULS in the treatment of advanced gastric cardia cancer...
November 18, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27753995/ed-06-3-blood-pressure-phenotype-associated-with-cardiovascular-risk-in-young-adults
#2
Yuichiro Yano
Younger adults (ages ≤50 years) are increasingly prone to stroke, chronic kidney disease (CKD), and worsening cardiovascular disease (CVD) mortality in the US. An alarming increase in prevalence of high blood pressure (BP) related to the obesity epidemic appears to underlie these adverse trends. However, what specific BP characteristics measured in young adulthood optimally predict incident CVD and CKD later in life remains to be determined. Therefore, an optimization of diagnostic and therapeutic strategies in BP management for young adults is challenging but essential...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27678324/stomach-cancer-burden-in-central-and-south-america
#3
Monica S Sierra, Patricia Cueva, Luis Eduardo Bravo, David Forman
RATIONALE AND OBJECTIVE: Stomach cancer mortality rates in Central and South America (CSA) are among the highest in the world. We describe the current burden of stomach cancer in CSA. METHODS: We obtained regional and national-level cancer incidence data from 48 population-based registries (13 countries) and nation-wide cancer deaths from WHO's mortality database (18 countries). We estimated world population age-standardized incidence (ASR) and mortality (ASMR) rates per 100,000 and estimated annual percent change to describe time trends...
September 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27642906/ed-06-3-blood-pressure-phenotype-associated-with-cardiovascular-risk-in-young-adults
#4
Yuichiro Yano
Younger adults (ages ≤50 years) are increasingly prone to stroke, chronic kidney disease (CKD), and worsening cardiovascular disease (CVD) mortality in the US. An alarming increase in prevalence of high blood pressure (BP) related to the obesity epidemic appears to underlie these adverse trends. However, what specific BP characteristics measured in young adulthood optimally predict incident CVD and CKD later in life remains to be determined. Therefore, an optimization of diagnostic and therapeutic strategies in BP management for young adults is challenging but essential...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27523409/-radiotherapy-in-cancers-of-the-oesophagus-the-gastric-cardia-and-the-stomach
#5
G Créhange, F Huguet, L Quero, T V N'Guyen, X Mirabel, T Lacornerie
Localized oesophageal and gastric cancers have a poor prognosis. In oesophageal cancer, external radiotherapy combined with concomitant chemotherapy is accepted as part of the therapeutic armamentarium in a curative intent in the preoperative setting for resectable tumours; or without surgery in inoperable patients or non-resectable tumours due to wide local and/or regional extension. Data from the literature show conflicting results with no clinical evidence in favour of either a unique dose protocol or consensual target volume definition in the setting of exclusive chemoradiation...
September 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27499162/helicobacter-pylori-infection-and-risk-of-gastric-cancer-in-korea-a-quantitative-systematic-review
#6
Jong-Myon Bae, Eun Hee Kim
OBJECTIVES: In the context of the global decrease in mortality due to gastric cancer, previous studies have reported that the effect of chronic Helicobacter pylori (H. pylori) infection on the incidence of gastric cancer varies among regions. This systematic review was conducted to investigate H. pylori as a risk factor for gastric cancer in Korea, where the incidence of gastric cancer is among the highest in the world. METHODS: A search strategy was established to identify articles published in Korean as well as in English...
July 2016: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/27343783/construction-of-a-tool-to-measure-perceptions-about-the-use-of-the-world-health-organization-safe-surgery-checklist-program
#7
Luis Antonio Dos Santos Diego, Fabiane Cardia Salman, João Henrique Silva, Julio Cezar Brandão, Getúlio de Oliveira Filho, Antonio Fernando Carneiro, Airton Bagatini, José Mariano de Moraes
BACKGROUND: The World Health Organization (WHO) has recommended greater attention to patient safety, particularly regarding preventable adverse events. The Safe Surgery Saves Lives (CSSV) program was released recommending the application of a surgical checklist for items on the safety of procedures. The checklist implementation reduced the hospital mortality rate in the first 30 days. In Brazil, we found no studies of anesthesiologists' adherence to the practice of the checklist. OBJECTIVE: The main objective was to develop a tool to measure the attitude of anesthesiologists and residents regarding the use of checklist in the perioperative period...
July 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27183032/association-of-leisure-time-physical-activity-with-risk-of-26-types-of-cancer-in-1-44-million-adults
#8
Steven C Moore, I-Min Lee, Elisabete Weiderpass, Peter T Campbell, Joshua N Sampson, Cari M Kitahara, Sarah K Keadle, Hannah Arem, Amy Berrington de Gonzalez, Patricia Hartge, Hans-Olov Adami, Cindy K Blair, Kristin B Borch, Eric Boyd, David P Check, Agnès Fournier, Neal D Freedman, Marc Gunter, Mattias Johannson, Kay-Tee Khaw, Martha S Linet, Nicola Orsini, Yikyung Park, Elio Riboli, Kim Robien, Catherine Schairer, Howard Sesso, Michael Spriggs, Roy Van Dusen, Alicja Wolk, Charles E Matthews, Alpa V Patel
IMPORTANCE: Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE: To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking. DESIGN, SETTING, AND PARTICIPANTS: We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004)...
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27179730/genetic-loci-associated-with-ideal-cardiovascular-health-a-meta-analysis-of-genome-wide-association-studies
#9
Norrina B Allen, Donald Lloyd-Jones, Shih-Jen Hwang, Laura Rasmussen-Torvik, Myriam Fornage, Alanna C Morrison, Abigail S Baldridge, Eric Boerwinkle, Daniel Levy, L Adrienne Cupples, Caroline S Fox, George Thanassoulis, Line Dufresne, Martha Daviglus, Andrew D Johnson, Jared Reis, Jerome Rotter, Walter Palmas, Mathew Allison, James S Pankow, Christopher J O'Donnell
BACKGROUND: Multiple genetic loci are associated with clinical cardiovascular (CV) disease and individual CV risk factors. Individuals with ideal levels of all major CV risk factors have very low risk for CV disease morbidity or mortality. Ideal levels of risk factors can be attained by lifestyle modifications; however, little is known about gene variants associated with ideal CV health. Our objective was to carry out a genome-wide association study on the trait. METHODS AND RESULTS: We examined 2 dichotomous phenotypes of ideal CV health-clinical (untreated cholesterol <200 mg/dL, untreated blood pressure <120/<80, not diabetic) and clinical+behavioral (clinical plus: not a current smoker, body mass index <25 kg/m(2))-among white participants aged 50±5 years...
May 2016: American Heart Journal
https://www.readbyqxmd.com/read/27170766/helicobacter-pylori-blood-biomarker-for-gastric-cancer-risk-in-east-asia
#10
Hui Cai, Fei Ye, Angelika Michel, Gwen Murphy, Shizuka Sasazuki, Philip R Taylor, You-Lin Qiao, Sue K Park, Keun-Young Yoo, Sun Ha Jee, Eo Rin Cho, Jeongseon Kim, Sheau-Chiann Chen, Christian C Abnet, Shoichiro Tsugane, Qiuyin Cai, Xiao-Ou Shu, Wei Zheng, Michael Pawlita, Meira Epplein
BACKGROUND: Incidence and mortality rates for gastric cancer, the fifth most commonly diagnosed and third most deadly cancer worldwide, are highest in East Asia. We sought to identify gastric cancer risk biomarkers among eight prospective studies from China, Japan and Korea. METHODS: This pooled nested case-control study included 1608 incident non-cardia gastric cancer cases and 1958 matched controls. Pre-diagnostic antibody levels to 15 Helicobacter pylori proteins were assessed using multiplex serology...
June 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/26988559/lutzomyia-migonei-is-a-permissive-vector-competent-for-leishmania-infantum
#11
Vanessa Cristina Fitipaldi Veloso Guimarães, Katerina Pruzinova, Jovana Sadlova, Vera Volfova, Jitka Myskova, Sinval Pinto Brandão Filho, Petr Volf
BACKGROUND: Leishmania infantum is the most widespread etiological agent of visceral leishmaniasis (VL) in the world, with significant mortality rates in human cases. In Latin America, this parasite is primarily transmitted by Lutzomyia longipalpis, but the role of Lutzomyia migonei as a potential vector for this protozoan has been discussed. Laboratory and field investigations have contributed to this hypothesis; however, proof of the vector competence of L. migonei has not yet been provided...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/26811556/computed-tomography-angiography-in-patients-with-active-gastrointestinal-bleeding
#12
REVIEW
Fatima Regina Silva Reis, Patricia Prando Cardia, Giuseppe D'Ippolito
Gastrointestinal bleeding represents a common medical emergency, with considerable morbidity and mortality rates, and a prompt diagnosis is essential for a better prognosis. In such a context, endoscopy is the main diagnostic tool; however, in cases where the gastrointestinal hemorrhage is massive, the exact bleeding site might go undetected. In addition, a trained professional is not always present to perform the procedure. In an emergency setting, optical colonoscopy presents limitations connected with the absence of bowel preparation, so most of the small bowel cannot be assessed...
November 2015: Radiologia Brasileira
https://www.readbyqxmd.com/read/26618471/association-of-fitness-in-young-adulthood-with-survival-and-cardiovascular-risk-the-coronary-artery-risk-development-in-young-adults-cardia-study
#13
Ravi V Shah, Venkatesh L Murthy, Laura A Colangelo, Jared Reis, Bharath Ambale Venkatesh, Ravi Sharma, Siddique A Abbasi, David C Goff, J Jeffrey Carr, Jamal S Rana, James G Terry, Claude Bouchard, Mark A Sarzynski, Aaron Eisman, Tomas Neilan, Saumya Das, Michael Jerosch-Herold, Cora E Lewis, Mercedes Carnethon, Gregory D Lewis, Joao A C Lima
IMPORTANCE: Although cardiorespiratory fitness (CRF) is prognostic in older adults, the effect of CRF during early adulthood on long-term cardiovascular structure, function, and prognosis is less clear. OBJECTIVE: To examine whether CRF in young adults is associated with long-term clinical outcome and subclinical cardiovascular disease (CVD). DESIGN, SETTING, AND PARTICIPANTS: Prospective study of 4872 US adults aged 18 to 30 years who underwent treadmill exercise testing at a baseline study visit from March 25, 1985, to June 7, 1986, and 2472 individuals who underwent a second treadmill test 7 years later...
January 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/26582388/-construction-of-a-tool-to-measure-perceptions-about-the-use-of-the-world-health-organization-safe-surgery-checklist-program
#14
Luis Antonio Dos Santos Diego, Fabiane Cardia Salman, João Henrique Silva, Julio Cezar Brandão, Getúlio de Oliveira Filho, Antonio Fernando Carneiro, Airton Bagatini, José Mariano de Moraes
BACKGROUND: The World Health Organization (WHO) has recommended greater attention to patient safety, particularly regarding preventable adverse events. The Safe Surgery Saves Lives (CSSV) program was released recommending the application of a surgical checklist for items on the safety of procedures. The checklist implementation reduced the hospital mortality rate in the first 30 days. In Brazil, we found no studies of anesthesiologists' adherence to the practice of the checklist. OBJECTIVE: The main objective was to develop a tool to measure the attitude of anesthesiologists and residents regarding the use of checklist in the perioperative period...
July 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/26458406/dna-methylation-inhibitor-decitabine-promotes-mgc803-gastric-cancer-cell-migration-and-invasion-via-the-upregulation-of-nedd4%C3%A2-1
#15
Dong Li, Chun-Yan Xu, Rong-Jun Cui, Jie-Bing Tang, Hui Sun, Zheng-Kai Yang, Jing-Yi Bu, Ping Lin, Ning Huang, Yan-Dan Du, Xiao-Guang Yu
Gastric cancer is the fourth most common cancer type and the second leading cause of cancer‑associated mortality worldwide. Metastasis is a crucial feature of its progression. DNA methylation provides a key epigenetic signature in the epigenetic regulation pathway, and is implicated in transcriptional regulation. CpG sites, which are associated with gene transcriptional activity, are underrepresented in the mammalian genome and tend to be clustered within CpG islands (CGIs) located in the vicinity of the transcription start sites of the majority of the protein‑coding genes in humans...
December 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26416411/defining-the-impact-of-surgical-approach-on-perioperative-outcomes-for-patients-with-gastric-cardia-malignancy
#16
Ryan W Day, Brian D Badgwell, Keith F Fournier, Paul F Mansfield, Thomas A Aloia
BACKGROUND: Gastric cardia cancer is currently treated with several operations. The purpose of the current study was to compare outcomes associated with three common operative approaches. METHODS: The ACS-NSQIP Participant Use File was searched to identify all patients with gastric cardia malignancy who underwent total gastrectomy (TG), transhiatal esophagectomy (THE), or thoraco-abdominal esophagectomy (TAE) between 2005 and 2012. Demographic, perioperative risk factors, and outcomes were analyzed...
January 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26391135/can-antihypertensive-treatment-restore-the-risk-of-cardiovascular-disease-to-ideal-levels-the-coronary-artery-risk-development-in-young-adults-cardia-study-and-the-multi-ethnic-study-of-atherosclerosis-mesa
#17
MULTICENTER STUDY
Kiang Liu, Laura A Colangelo, Martha L Daviglus, David C Goff, Mark Pletcher, Pamela J Schreiner, Christopher T Sibley, Gregory L Burke, Wendy S Post, Erin D Michos, Donald M Lloyd-Jones
BACKGROUND: It is unclear whether antihypertensive treatment can restore cardiovascular disease risk to the risk level of persons with ideal blood pressure (BP) levels. METHODS AND RESULTS: Data from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Coronary Artery Risk Development in Young Adults (CARDIA) study were analyzed. Outcomes were compared among participants without or with antihypertensive treatment at 3 BP levels: <120/<80 mm Hg, systolic BP 120 to 139 mm Hg or diastolic BP 80 to 89 mm Hg (120 to 129/≤80 mm Hg for participants with diabetes), and systolic BP ≥140 or diastolic BP ≥90 mm Hg (systolic BP ≥130 or diastolic BP ≥80 mm Hg for participants with diabetes)...
September 21, 2015: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26275537/long-term-outcomes-of-combined-endoscopic-laparoscopic-intragastric-enucleation-of-presumed-gastric-stromal-tumors
#18
Jeffrey S Mino, Alfredo D Guerron, Rosebel Monteiro, Kevin El-Hayek, Jeffrey L Ponsky, Deepa T Patil, R Matthew Walsh
PURPOSE: Definitive surgical treatment of gastric myogenic neoplasms such as gastrointestinal stromal tumors (GISTs) typically involves full-thickness resection of the lesion with normal gastric wall as the margin. This is not readily possible with proximal gastric lesions near the gastroesophageal junction, nor necessary for small incidental lesions. We have employed a combined endoscopic/laparoscopic intraluminal enucleation technique for selected patients and report long-term surveillance following this novel technique...
May 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26215366/-long-term-outcome-of-neoadjuvant-radiochemotherapy-followed-by-surgery-for-esophageal-cancer-a-single-institution-retrospective-study-of-102-patients
#19
A Ruffier-Loubière, G Janoray, S Chapet, L de Calan, P Dumont, É Dorval, I Orain, G Calais
PURPOSE AND OBJECTIVES: To report survival and morbidity of a large homogeneous cohort of patients with a locally advanced esophageal or cardia carcinoma and put in evidence predictive factors of locoregional control and survival. PATIENTS AND METHODS: Hundred and two patients were treated at the university hospital of Tours between 1990 and 2010 and received neo-adjuvant chemoradiation therapy with external irradiation (40Gy-44Gy) and two courses of chemotherapy (5-fluoro-uracile and cisplatine)...
August 2015: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/25986493/intrathoracic-anastomotic-leakage-after-gastroesophageal-cancer-resection-is-associated-with-increased-risk-of-recurrence
#20
Steen C Kofoed, Dan Calatayud, Lone S Jensen, Frederik Helgstrand, Michael P Achiam, Pieter De Heer, Lars B Svendsen
OBJECTIVE: Intrathoracic anastomotic leakage after intended curative resection for cancer in the esophagus or gastroesophageal junction has a negative impact on long-term survival. The aim of this study was to investigate whether an anastomotic leakage was associated with an increased recurrence rate. METHODS: This nationwide study included consecutively collected data on patients undergoing curative surgical resection with intrathoracic anastomosis, alive 8 weeks postoperatively, between 2003 and 2011...
July 2015: Journal of Thoracic and Cardiovascular Surgery
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