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https://www.readbyqxmd.com/read/28221725/-from-the-great-mystery-with-which-anatomical-pursuits-have-hitherto-been-shrouded
#1
EDITORIAL
R Shane Tubbs
No abstract text is available yet for this article.
March 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28221240/the-residual-vaccine-preventable-burden-of-rotavirus-disease
#2
Bethany K Sederdahl, Jumi Yi, Robert Jerris, Scott E Gillespie, Lars F Westblade, Colleen S Kraft, Andi L Shane, Ben Lopman, Evan J Anderson
From July 2007-June 2015, 61% of rotavirus-positive, vaccine-eligible children were unvaccinated for rotavirus. Of these, 67% of children had received DTaP within the recommended age for rotavirus vaccine initiation. Improving linkage between rotavirus and DTaP administration may impact the residual burden of U.S. rotavirus disease.
February 15, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28218468/igf-1-receptor-expression-on-circulating-osteoblast-progenitor-cells-predicts-tissue-based-bone-formation-rate-and-response-to-teriparatide-in-premenopausal-women-with-idiopathic-osteoporosis
#3
Adi Cohen, Stavroula Kousteni, Brygida Bisikirska, Jayesh G Shah, J Sanil Manavalan, Robert R Recker, Joan Lappe, David W Dempster, Hua Zhou, Donald J McMahon, Mariana Bucovsky, Mafo Kamanda-Kosseh, Julie Stubby, Elizabeth Shane
We have previously reported that premenopausal women with idiopathic osteoporosis (IOP) have profound microarchitectural deficiencies and heterogeneous bone remodeling. Those with the lowest bone formation rate have higher baseline serum IGF-1 levels and less robust response to teriparatide. Because IGF-1 stimulates bone formation and is critical for teriparatide action on osteoblasts, these findings suggest a state of IGF-1 resistance in some IOP women. To further investigate the hypothesis that osteoblast and IGF-1 related mechanisms mediate differential responsiveness to teriparatide in IOP, we studied circulating osteoblast progenitor (COP) cells and their IGF-1 receptor (IGF-1R) expression...
February 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28218432/becn2-interacts-with-atg14-through-a-metastable-coiled-coil-to-mediate-autophagy
#4
Minfei Su, Yue Li, Shane Wyborny, David Neau, Srinivas Chakravarthy, Beth Levine, Christopher L Colbert, Sangita C Sinha
ATG14 binding to BECN/Beclin homologs is essential for autophagy, a critical catabolic homeostasis pathway. Here we show that the α-helical, coiled-coil domain (CCD) of BECN2, a recently identified mammalian BECN1 paralog, forms an anti-parallel, curved homodimer with seven pairs of non-ideal packing interactions, while the BECN2 CCD and ATG14 CCD form a parallel, curved heterodimer stabilized by multiple, conserved polar interactions. Compared to BECN1, the BECN2 CCD forms a weaker homodimer, but binds more tightly to the ATG14 CCD...
February 20, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28216684/perioperative-analgesic-use-by-ontario-veterinarians-2012
#5
Jessica Reimann, Cate Dewey, Shane W Bateman, Carolyn Kerr, Ron Johnson
The objectives of this study were to describe the routine use of analgesics by Ontario veterinarians for common surgeries in dogs and cats, and to compare routine use of analgesics between species and surgeries, using Chi-square analyses. In total, 239 veterinarians responded to the questionnaires; a response rate of 13.1%. Fifty-two percent to 79% of veterinarians used meloxicam for both species and all surgeries. Approximately 9% of veterinarians did not use analgesics for dog ovariohysterectomy and castration, while 16% to 22% did not use analgesics for these surgeries in cats...
February 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28216146/divergent-levels-of-marker-chromosomes-in-an-hipsc-based-model-of%C3%A2-psychosis
#6
Julia Tcw, Claudia M B Carvalho, Bo Yuan, Shen Gu, Alyssa N Altheimer, Shane McCarthy, Dheeraj Malhotra, Jonathan Sebat, Arthur J Siegel, Uwe Rudolph, James R Lupski, Deborah L Levy, Kristen J Brennand
In the process of generating presumably clonal human induced pluripotent stem cells (hiPSCs) from two carriers of a complex structural rearrangement, each having a psychotic disorder, we also serendipitously generated isogenic non-carrier control hiPSCs, finding that the rearrangement occurs as an extrachromosomal marker (mar) element. All confirmed carrier hiPSCs and differentiated neural progenitor cell lines were found to be mosaic. We caution that mar elements may be difficult to functionally evaluate in hiPSC cultures using currently available methods, as it is difficult to distinguish cells with and without mar elements in live mosaic cultures...
February 9, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28215730/effects-of-intracerebral-neurotrophic-factor-application-on-motor-symptoms-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#7
REVIEW
Shane V Hegarty, David J Lee, Gerard W O'Keeffe, Aideen M Sullivan
INTRODUCTION: Neurotrophic factors (NTFs) have been evaluated for neuroprotective effects in Parkinson's disease (PD). However, clinical trials examining the efficacy of intracerebral administration of NTFs on motor symptoms in PD have produced mixed results, and are thus inconclusive. The objective of this systematic review and meta-analysis was to determine the effects of intracerebral NTF application on motor symptoms in people with PD. METHODS: We searched PubMed, MEDLINE, EMBASE, and Cochrane from inception through to March 31 2016 for open-label trials and randomized controlled trials (RCTs) which intracerebrally administered NTFs to PD patients, and which performed motor examination using the Unified Parkinson's Disease Rating Scale...
February 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28213588/a-differential-autophagy-dependent-response-to-dna-double-strand-brakes-in-bone-marrow-mesenchymal-stem-cells-from-sporadic-als-patients
#8
Shane Wald-Altman, Edward Pichinuk, Or Kakhlon, Miguel Weil
Amyotrophic Lateral Sclerosis (ALS) is an incurable motor neurodegenerative disease caused by a diversity of genetic and environmental factors leading to neuromuscular degeneration and pathophysiological implications in non-neural systems. Our previous work showed abnormal transcriptional expression levels of biomarker genes in non-neuronal cell samples from ALS patients. The same genes proved to be differentially expressed in brain, spinal cord and muscle of the SOD1(G93A) ALS mouse model. These observations support the pathophysiological relevance of the ALS biomarkers discovered in human mesenchymal stem cells (hMSC) isolated from bone marrow samples of ALS patients (ALS-hMSC)...
February 16, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28212692/oxygen-desaturation-index-differs-significantly-between-types-of-sleep-software
#9
Yvonne Ng, Simon A Joosten, Bradley A Edwards, Anthony Turton, Helen Romios, Thilini Samarasinghe, Shane Landry, Darren R Mansfield, Garun S Hamilton
STUDY OBJECTIVES: The aim of this study was to compare the oxygen desaturation index (ODI) generated by two different sleep software systems. METHODS: Participants undergoing diagnostic polysomnography for suspected obstructive sleep apnea underwent simultaneous oximetry recording using the ResMedApneaLink Plus device (AL) and Compumedics Profusion PSG3 system (Comp). The ODI was calculated by the algorithms in the respective software of each system. To determine if differences were due to algorithm or recording devices, the Comp software was also used to generate ODI values using oximetry data from the AL...
February 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28209401/the-effect-of-prophylactic-cerclage-wires-in-primary-total-hip-arthroplasty-a-biomechanical-study
#10
Andrew C Waligora, John R Owen, Jennifer S Wayne, Shane R Hess, Gregory J Golladay, William A Jiranek
BACKGROUND: Despite literature to support the use of various cerclage techniques to address intraoperative femoral fractures in total hip arthroplasty, there are limited data to support prophylactic cerclage wiring of the femur during cementless implant placement. This study aims to evaluate the effect of prophylactic calcar cerclage wires on the biomechanical parameters required to produce periprosthetic femoral fractures and on the morphology of these fracture patterns in stable cementless femoral implants...
January 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28208152/simultaneous-umbilical-hernia-repair-with-transumbilical-ventriculoperitoneal-shunt-placement
#11
Michael J Montalbano, Marios Loukas, W Jerry Oakes, R Shane Tubbs
INTRODUCTION: Recently, placement of a ventriculoperitoneal shunt via a transumbilical approach has been reported. PATIENTS AND METHODS: Herein, we report the repair of an umbilical hernia via the same incision and introduction of the distal end of a ventricultoperitoneal shunt into the peritoneal cavity in 3 patients. A case illustration is included. RESULTS: Both hernia repair and placement of the distal end of the ventriculoperitoneal shunt were uncomplicated in our small case series...
February 17, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28205675/bcftools-csq-haplotype-aware-variant-consequences
#12
Petr Danecek, Shane A McCarthy
No abstract text is available yet for this article.
February 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28205508/global-dynamics-of-non-equilibrium-gliding-in-animals
#13
Isaac Yeaton, Jake Socha, Shane Ross
Gliding flight - moving horizontally downward through the air without power - has evolved in a broad diversity of taxa and serves numerous ecologically relevant functions such as predator escape, expanding foraging locations, and finding mates, and has been suggested as an evolutionary pathway to powered flight. Historically, gliding has been conceptualized using the idealized conditions of equilibrium, in which the net aerodynamic force on the glider balances its weight. While this assumption is appealing for its simplicity, recent studies of glide trajectories have shown that equilibrium gliding is not the norm for most species...
February 16, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28204995/dalteparin-or-vitamin-k-antagonists-to-prevent-recurrent-venous-thromboembolism-in-cancer-patients-a-patient-level-economic-analysis-for-france-and-austria
#14
George Dranitsaris, Lesley G Shane, Jean-Philippe Galanaud, Gunar Stemer, Philippe Debourdeau, Seth Woodruff
BACKGROUND: International guidelines recommend extended duration secondary prophylaxis in cancer patients who develop primary venous thromboembolism (VTE). Agent selection is guided in part by one large randomized trial (i.e., CLOT; Lee et al., N Engl J Med 349:146-53, 2003) which demonstrated that dalteparin reduced the relative risk of recurrence by 52% compared with oral vitamin K antagonists (VKA; HR = 0.48, 95% CI, 0.30 to 0.77). In a subgroup analysis from that same trial, patients with renal impairment also derived benefit with dalteparin (VTE rates = 3% vs...
February 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28203210/auditory-and-visual-electrophysiology-of-deaf-children-with-cochlear-implants-implications-for-cross-modal-plasticity
#15
David P Corina, Shane Blau, Todd LaMarr, Laurel A Lawyer, Sharon Coffey-Corina
Deaf children who receive a cochlear implant early in life and engage in intensive oral/aural therapy often make great strides in spoken language acquisition. However, despite clinicians' best efforts, there is a great deal of variability in language outcomes. One concern is that cortical regions which normally support auditory processing may become reorganized for visual function, leaving fewer available resources for auditory language acquisition. The conditions under which these changes occur are not well understood, but we may begin investigating this phenomenon by looking for interactions between auditory and visual evoked cortical potentials in deaf children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28202156/the-status-value-theory-of-power-and-mechanisms-of-micro-stratification-theory-and-new-experimental-evidence
#16
Shane R Thye, Ashley Harrell
This paper employs sociological theories of status and power to explore the mechanisms wherein status characteristics produce power in exchange relations. Theories in the status and exchange literature suggest that status characteristics produce power most strongly when actors possess (i) multiple differentiating status characteristics, and (ii) multiple resources. An experiment manipulating these factors finds that the former is related to expectations of competence while the latter induces perceptions of status value - mechanisms whereby status produces power...
March 2017: Social Science Research
https://www.readbyqxmd.com/read/28199788/development-of-fluorescence-surrogates-to-predict-the-photochemical-transformation-of-pharmaceuticals-in-wastewater-effluents
#17
Shuwen Yan, Bo Yao, Lushi Lian, Xinchen Lu, Shane A Snyder, Rui Li, Weihua Song
The photochemical transformation of pharmaceutical and personal care products (PPCPs) in wastewater effluents is an emerging concern for environmental scientists. In the current study, the photodegradation of 29 PPCPs was examined in effluents under simulated solar irradiation. Direct photodegradation, triplet state effluent organic matter (3EfOM*)-mediated and hydroxyl radical (HO•)-mediated degradation are three major pathways in the removal process. With the photodegradation of trace levels of PPCPs, the excitation-emission matrix (EEM) fluorescence intensities of the effluents were also gradually reduced...
February 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28197991/transformation-of-porokeratosis-ptychotropica-into-invasive-squamous-cell-carcinoma
#18
Daniel R Mazori, Marianna Shvartsbeyn, Shane A Meehan, Sara L Tarsis
No abstract text is available yet for this article.
February 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28196971/multilocus-sequence-typing-identifies-an-avian-like-chlamydia-psittaci-strain-involved-in-equine-placentitis-and-associated-with-subsequent-human-psittacosis
#19
LETTER
Martina Jelocnik, James Branley, Jane Heller, Shane Raidal, Susan Alderson, Francesca Galea, Melinda Gabor, Adam Polkinghorne
No abstract text is available yet for this article.
February 15, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28196937/magnetic-resonance-imaging-plaque-hemorrhage-for-risk-stratification-in-carotid-artery-disease-with-moderate-risk-under-current-medical-therapy
#20
Akram A Hosseini, Richard J Simpson, Nishath Altaf, Philip M Bath, Shane T MacSweeney, Dorothee P Auer
BACKGROUND AND PURPOSE: Magnetic resonance imaging (MRI)-defined carotid plaque hemorrhage (MRIPH) can predict recurrent cerebrovascular ischemic events in severe symptomatic carotid stenosis. It is less clear whether MRIPH can improve risk stratification despite optimized medical secondary prevention in those with moderate risk. METHODS: One-hundred fifty-one symptomatic patients with 30% to 99% carotid artery stenosis (median age: 77, 60.5% men) clinically deemed to not benefit from endarterectomy were prospectively recruited to undergo MRI and clinical follow-up (mean, 22 months)...
February 14, 2017: Stroke; a Journal of Cerebral Circulation
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