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https://www.readbyqxmd.com/read/29457672/gambling-related-cognitive-distortions-predict-level-of-function-among-us-veterans-seeking-treatment-for-gambling-disorders
#1
Steven D Shirk, Megan M Kelly, Shane W Kraus, Marc N Potenza, Kendra Pugh, Christopher Waltrous, Edward Federman, Christopher Krebs, Charles E Drebing
BACKGROUND AND OBJECTIVES: Gambling Disorder (GD) is characterized by recurrent gambling behavior that is associated with significant impairment and distress, high psychiatric comorbidities, and high functional disability. The military veteran population appears particularly susceptible to developing the disorder, but relatively little has been studied among this population. The purpose of the present study is to investigate the clinical psychopathologies and comorbidities of veterans seeking treatment for problem gambling and how problem gambling may impact functioning...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29456905/a-comprehensive-review-of-the-sternal-foramina-and-its-clinical-significance
#2
REVIEW
Paul J Choi, Joe Iwanaga, R Shane Tubbs
A sternal foramen (SF), which arises from the incomplete fusion of the cartilaginous neonatal sternum, is a relatively common anatomical variation found in 2.5% to 13.8 % of all individuals. SFs are usually located at the lower third of the sternal body and their average diameter is 6.5 mm. An SF is subclinical; however, its close proximity to the thoracic organs, i.e., the heart and lungs, entails a risk of serious complications from blinded sternal interventions. Moreover, its presence can lead to misinterpretation of radiological and postmortem findings...
December 8, 2017: Curēus
https://www.readbyqxmd.com/read/29456903/winged-scapula-a-comprehensive-review-of-surgical-treatment
#3
REVIEW
Marc Vetter, Ordessia Charran, Emre Yilmaz, Bryan Edwards, Mitchel A Muhleman, Rod J Oskouian, R Shane Tubbs, Marios Loukas
Winged scapula is caused by paralysis of the serratus anterior or trapezius muscles due to damage to the long thoracic or accessory nerves, resulting in loss of strength and range of motion of the shoulder. Because this nerve damage can happen in a variety of ways, initial diagnosis may be overlooked. This paper discusses the anatomical structures involved in several variations of winged scapula, the pathogenesis of winged scapula, and several historical and contemporary surgical procedures used to treat this condition...
December 7, 2017: Curēus
https://www.readbyqxmd.com/read/29455701/estimating-the-pathways-through-which-maternal-education-affects-stunting-evidence-from-an-urban-cohort-in-south-africa
#4
Daniela Casale, Gabriel Espi, Shane A Norris
OBJECTIVE: To estimate the determinants of stunting using rich data from a birth cohort study from urban South Africa and to examine the various mechanisms, both proximate and distal, through which maternal education affects stunting. DESIGN: Multivariate regression analysis using birth cohort data, where the outcome variable was stunting at age 2 years, and multiple mediator analysis to identify pathways from maternal education to stunting. SETTING: South Africa's largest metropolitan area, Soweto-Johannesburg...
February 19, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29454119/anatomical-study-of-the-nutrient-foramina-of-the-posterior-axis-with-application-to-c2-pedicle-screw-placement
#5
Tamir Tawfik, Joe Iwanaga, Emre Yilmaz, Paul Choi, Charlotte Wilson, Emily Simonds, Jared J Marks, Haynes L Harkey, Rod J Oskouian, R Shane Tubbs
OBJECTIVE: Pedicle screws placed into C2 necessitate a thorough understanding of this bone's unique anatomy. Although multiple landmarks and measurements have been used by surgeons, these are often varied in the literature with no consensus. Herein, we studied one recently proposed landmark using the nutrient foramina of the posterior aspect of C2 for pedicle screw placement. METHODS: On 19 (38 sides) C2 dry bone specimens, the presence, size, location, and distance from the midline of the nutrient foramina found at the junction between the isthmus and lamina were documented and measured...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29450888/spatiotemporal-heterogeneity-in-prey-abundance-and-vulnerability-shapes-the-foraging-tactics-of-an-omnivore
#6
Nathaniel D Rayl, Guillaume Bastille-Rousseau, John F Organ, Matthew A Mumma, Shane P Mahoney, Colleen E Soulliere, Keith P Lewis, Robert D Otto, Dennis L Murray, Lisette P Waits, Todd K Fuller
1.Prey abundance and prey vulnerability vary across space and time, but we know little about how they mediate predator-prey interactions and predator foraging tactics. To evaluate the interplay between prey abundance, prey vulnerability, and predator space use, we examined patterns of black bear (Ursus americanus) predation of caribou (Rangifer tarandus) neonates in Newfoundland, Canada using data from 317 collared individuals (9 bears, 34 adult female caribou, 274 caribou calves). 2.During the caribou calving season, we predicted that landscape features would influence calf vulnerability to bear predation, and that bears would actively hunt calves by selecting areas associated with increased calf vulnerability...
February 16, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29450800/the-endogenous-subcellular-localisations-of-the-long-chain-fatty-acid-activating-enzymes-acsl3-and-acsl4-in-sarcoma-and-breast-cancer-cells
#7
Yassmeen Radif, Haarith Ndiaye, Vasiliki Kalantzi, Ruth Jacobs, Andrew Hall, Shane Minogue, Mark G Waugh
Fatty acid uptake and metabolism are often dysregulated in cancer cells. Fatty acid activation is a critical step that allows these biomolecules to enter cellular metabolic pathways such as mitochondrial β-oxidation for ATP generation or the lipogenic routes that generate bioactive lipids such as the inositol phospholipids. Fatty acid activation by the addition of coenzyme A is catalysed by a family of enzymes called the acyl CoA synthetase ligases (ACSL). Furthermore, enhanced expression of particular ACSL isoforms, such as ACSL4, is a feature of some more aggressive cancers and may contribute to the oncogenic phenotype...
February 15, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29450606/combination-transarterial-chemoembolization-and-microwave-ablation-improves-local-tumor-control-for-3-to-5-cm-hepatocellular-carcinoma-when-compared-with-transarterial-chemoembolization-alone
#8
Amanda R Smolock, Mircea M Cristescu, Audrey Hinshaw, Kaitlin M Woo, Shane A Wells, Timothy J Ziemlewicz, Meghan G Lubner, Prasad S Dalvie, J Louis Hinshaw, Christopher L Brace, Orhan S Ozkan, Fred T Lee, Paul Laeseke
PURPOSE: To compare transarterial chemoembolization (TACE) monotherapy to combination TACE and microwave ablation (MWA) for local control of 3- to 5-cm hepatocellular carcinoma (HCC). METHODS: Patients with HCC between 3 and 5 cm treated with TACE monotherapy or combination TACE + MWA at a single institution between 2007 and 2016 were retrospectively reviewed. Twenty-four HCCs (median diameter 3.8 cm) in 16 patients (13 males; median age 64 years) were treated using TACE monotherapy...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29450254/correlates-of-cannabis-vape-pen-use-and-knowledge-among-u-s-college-students
#9
Tessa Frohe, Robert F Leeman, Julie Patock-Peckham, Anthony Ecker, Shane Kraus, Dawn W Foster
Introduction: The proliferation of electronic devices, such as vape-pens, has provided alternative means for cannabis use. Research has found cannabis-vaping (i.e., vape-pen use) is associated with lower perceived risks and higher cannabis use. Knowledge of these products may increase likelihood of subsequent use. As policies for cannabis shift, beliefs that peers and family approve of this substance use (injunctive norms) increase and there has been an increase in vape-pen use among young adults (18-35 year olds); however, correlates thereof remain unknown...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29449855/microrna160-modulates-plant-development-and-heat-shock-protein-gene-expression-to-mediate-heat-tolerance-in-arabidopsis
#10
Jeng-Shane Lin, Chia-Chia Kuo, I-Chu Yang, Wei-An Tsai, Yu-Hsing Shen, Chih-Ching Lin, Yi-Chen Liang, Yu-Chi Li, Yun-Wei Kuo, Yu-Chi King, Hsi-Mei Lai, Shih-Tong Jeng
Global warming is causing a negative impact on plant growth and adversely impacts on crop yield. MicroRNAs (miRNAs) are critical in regulating the expression of genes involved in plant development as well as defense responses. The effects of miRNAs on heat-stressed Arabidopsis warrants further investigation. Heat stress increased the expression of miR160 and its precursors but considerably reduced that of its targets, ARF10, ARF16 , and ARF17 . To study the roles of miR160 during heat stress, transgenic Arabidopsis plants overexpressing miR160 precursor a (160OE) and artificial miR160 (MIM160), which mimics an inhibitor of miR160, were created...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29447790/fine-particulate-matter-and-incident-coronary-heart-disease-in-the-regards-cohort
#11
Matthew Shane Loop, Leslie A McClure, Emily B Levitan, Mohammad Z Al-Hamdan, William L Crosson, Monika M Safford
Chronic exposure to fine particulate matter (PM 2.5 ) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of the effect of chronic exposure to PM 2.5 on risk for CHD do not generalize to more diverse samples. METHODS: Therefore, we estimated the relationship between chronic exposure to PM 2...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447658/primary-anetoderma-with-undifferentiated-connective-tissue-disease
#12
Lana X Tong, Jenna Beasley, Shane Meehan, Evan Rieder, Miriam Pomeranz, Kristen Lo Sicco, Alisa Femia, Randie Kim, Andrew G Franks
Anetoderma is a rare benign elastolytic disorder that is characterized by focal loss of elastin fibers on histopathology and is often recalcitrant to treatment. We present a case of a patient with a 20-year history of pruritic and painful hyperpigmented atrophic papules clustered on the neck, axillae, inframammary folds, and right medial thigh. Although the histopathologyof her axillary lesions was consistent with anetoderma, her clinical presentation is unusual given the extent of involvement, reported pain and pruritus, and sharp demarcation of the distribution...
December 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447654/papular-mucinosis-or-localized-lichen-myxedematosis-lm-discrete-papular-type
#13
Mitalee P Christman, Kumar Sukhdeo, Randie H Kim, Shane Meehan, Evan Rieder, Kristen Lo Sicco, Andrew Franks
Lichen myxedematosus is condition characterized by localized areas of dermal deposition of mucin, presenting with firm papules localized to few areas of the body. The condition needs to be excluded from scleromyxedema, which, in addition to the firm papular eruption, has areas of induration and is usually associated with a monoclonal gammopathyand systemic symptoms. We present a 62-year-old woman with a several-year history of asymptomatic, firm papules over the face and arms with no evidence of thyroid disease or a monoclonal gammopathy,which is consistent with a diagnosis of localized lichen myxedematosus, the discrete papular variant...
December 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29446948/a-structure-activity-relationship-study-of-bitopic-n6-substituted-adenosine-derivatives-as-biased-adenosine-a1-receptor-agonists
#14
Luigi Aurelio, Jo-Anne Baltos, Leigh Ford, Anh T N Nguyen, Manuela Jörg, Shane M Devine, Celine Valant, Paul J White, Arthur Christopoulos, Lauren T May, Peter J Scammells
Herein, we investigate the structure-activity relationships of a series of compounds derived from the bitopic N6-substituted adenosine derivative 1, a previously reported biased ligand at the A1 adenosine receptor. Modifications were made to the orthosteric adenosine pharmacophore, the linker and the allosteric 2-amino-3-benzoylthiophene pharmacophore to probe the structure-activity relationships, both in terms of the effect of these modifications on biased signalling as well as receptor subtype selectivity...
February 15, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29444345/completed-suicide-among-methamphetamine-users-a-national-study
#15
Shane Darke, Sharlene Kaye, Johan Duflou, Julia Lappin
All Australian cases of methamphetamine-related suicide (2009-2015) retrieved from the National Coronial Information System were examined to determine crude mortality rates, characteristics and circumstances of death, and blood toxicology. There were 300 cases, 18.2% of all methamphetamine-related deaths, and 1.6% of all completed suicides. The mean age was 33.1 years, and 77.0% were male. The crude mortality rate was 1.9 per 10 6 , with males having a significantly higher rate than females (2.9 vs. 0.9 per 10 6 )...
February 14, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29442577/high-rate-of-return-to-yoga-for-athletes-after-hip-arthroscopy-for-femoroacetabular-impingement-syndrome
#16
Rachel M Frank, Gift Ukwuani, Bradley Allison, Ian Clapp, Shane J Nho
BACKGROUND: Femoroacetabular impingement syndrome (FAIS) is most commonly diagnosed in patients who perform activities that require repetitive hip flexion and rotational loading. Yoga is an activity growing in popularity that involves these motions. The purpose of this study was to evaluate patients' ability to return to yoga after hip arthroscopy for FAIS. HYPOTHESIS: There would be a high rate of return to yoga after hip arthroscopy. STUDY DESIGN: Retrospective analysis...
February 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29440592/eligulum-a-regulates-lateral-branch-and-leaf-development-in-barley
#17
Ron J Okagaki, Allison Haaning, Hatice Bilgic, Shane Heinen, Arnis Druka, Micha Bayer, Robbie Waugh, Gary J Muehlbauer
The shoot apical and axillary meristems control shoot development, effectively influencing lateral branch and leaf formation. The barley (Hordeum vulgare L.) uniculm2 (cul2) mutation blocks axillary meristem development and mutant plants lack lateral branches (tillers) that normally develop from the crown. A genetic screen for cul2 suppressors recovered two recessive alleles of ELIGULUM-A (ELI-A) that partially rescued the cul2 tillering phenotype. Mutations in ELI-A produce shorter plants with fewer tillers and disrupt the leaf blade-sheath boundary, producing liguleless leaves and reduced secondary cell wall development in stems and leaves...
February 12, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29437957/normal-aging-induces-a1-like-astrocyte-reactivity
#18
Laura E Clarke, Shane A Liddelow, Chandrani Chakraborty, Alexandra E Münch, Myriam Heiman, Ben A Barres
The decline of cognitive function occurs with aging, but the mechanisms responsible are unknown. Astrocytes instruct the formation, maturation, and elimination of synapses, and impairment of these functions has been implicated in many diseases. These findings raise the question of whether astrocyte dysfunction could contribute to cognitive decline in aging. We used the Bac-Trap method to perform RNA sequencing of astrocytes from different brain regions across the lifespan of the mouse. We found that astrocytes have region-specific transcriptional identities that change with age in a region-dependent manner...
February 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29437277/identification-of-native-and-post-translationally-modified-hla-b-57-01-restricted-hiv-envelope-derived-epitopes-using-immunoproteomics
#19
Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda W S Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane Thomas, Stephen J Kent, Nicola Ternette, Damian F J Purcell, Jamie Rossjohn, Anthony W Purcell
The recognition of pathogen-derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antigens are degraded in the cytosol and short peptides assemble with class I human leukocyte antigen (HLA) molecules in the endoplasmic reticulum (ER). These peptide-HLA complexes egress to the cell surface and are scrutinized by cytotoxic CD8+ T-cells leading to the eradication of the infected cell. Here we identify naturally presented HLA-B*57:01 bound peptides derived from the envelope protein of the human immunodeficiency virus (HIVenv)...
February 13, 2018: Proteomics
https://www.readbyqxmd.com/read/29436081/-we-anatomists-are-like-porters-in-paris%C3%A2
#20
EDITORIAL
R Shane Tubbs
No abstract text is available yet for this article.
March 2018: Clinical Anatomy
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