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https://www.readbyqxmd.com/read/29678866/gaps-in-guidelines-for-the-management-of-diabetes-in-low-and-middle-income-versus-high-income-countries-a-systematic-review
#1
REVIEW
Mayowa O Owolabi, Joseph O Yaria, Meena Daivadanam, Akintomiwa I Makanjuola, Gary Parker, Brian Oldenburg, Rajesh Vedanthan, Shane Norris, Ayodele R Oguntoye, Morenike A Osundina, Omarys Herasme, Sulaiman Lakoh, Luqman O Ogunjimi, Sarah E Abraham, Paul Olowoyo, Carolyn Jenkins, Wuwei Feng, Hernán Bayona, Sailesh Mohan, Rohina Joshi, Ruth Webster, Andre P Kengne, Antigona Trofor, Lucia Maria Lotrean, Devarsetty Praveen, Jessica H Zafra-Tanaka, Maria Lazo-Porras, Kirsten Bobrow, Michaela A Riddell, Konstantinos Makrilakis, Yannis Manios, Bruce Ovbiagele
OBJECTIVE: The extent to which diabetes (DM) practice guidelines, often based on evidence from high-income countries (HIC), can be implemented to improve outcomes in low- and middle-income countries (LMIC) is a critical challenge. We carried out a systematic review to compare type 2 DM guidelines in individual LMIC versus HIC over the past decade to identify aspects that could be improved to facilitate implementation. RESEARCH DESIGN AND METHODS: Eligible guidelines were sought from online databases and websites of diabetes associations and ministries of health...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29678540/quantitative-diffusion-mri-using-reduced-field-of-view-and-multi-shot-acquisition-techniques-validation-in-phantoms-and-prostate-imaging
#2
Yuxin Zhang, James Holmes, Iñaki Rabanillo, Arnaud Guidon, Shane Wells, Diego Hernando
PURPOSE: To evaluate the reproducibility of quantitative diffusion measurements obtained with reduced Field of View (rFOV) and Multi-shot EPI (msEPI) acquisitions, using single-shot EPI (ssEPI) as a reference. METHODS: Diffusion phantom experiments, and prostate diffusion-weighted imaging in healthy volunteers and patients with known or suspected prostate cancer were performed across the three different sequences. Quantitative diffusion measurements of apparent diffusion coefficient, and diffusion kurtosis parameters (healthy volunteers), were obtained and compared across diffusion sequences (rFOV, msEPI, and ssEPI)...
April 17, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29678436/three-cases-of-anaphylaxis-to-protamine-management-of-anticoagulation-reversal
#3
Kamen Valchanov, Florian Falter, Shane George, Christina Burt, Andrew Roscoe, Choo Ng, Martin Besser, Shuaib Nasser
No abstract text is available yet for this article.
March 13, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29676956/high-intensity-interval-training-after-stroke-an-opportunity-to-promote-functional-recovery-cardiovascular-health-and-neuroplasticity
#4
Jennifer Crozier, Marc Roig, Janice J Eng, Marilyn MacKay-Lyons, Joyce Fung, Michelle Ploughman, Damian M Bailey, Shane N Sweet, Nicholas Giacomantonio, Alexander Thiel, Michael Trivino, Ada Tang
INTRODUCTION: Stroke is the leading cause of adult disability. Individuals poststroke possess less than half of the cardiorespiratory fitness (CRF) as their nonstroke counterparts, leading to inactivity, deconditioning, and an increased risk of cardiovascular events. Preserving cardiovascular health is critical to lower stroke risk; however, stroke rehabilitation typically provides limited opportunity for cardiovascular exercise. Optimal cardiovascular training parameters to maximize recovery in stroke survivors also remains unknown...
April 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29676945/model-for-predicting-breast-cancer-risk-in-women-with-atypical-hyperplasia
#5
Amy C Degnim, Stacey J Winham, Ryan D Frank, V Shane Pankratz, William D Dupont, Robert A Vierkant, Marlene H Frost, Tanya L Hoskin, Celine M Vachon, Karthik Ghosh, Tina J Hieken, Jodi M Carter, Lori A Denison, Brendan Broderick, Lynn C Hartmann, Daniel W Visscher, Derek C Radisky
Purpose Women with atypical hyperplasia (AH) on breast biopsy have an aggregate increased risk of breast cancer (BC), but existing risk prediction models do not provide accurate individualized estimates of risk in this subset of high-risk women. Here, we used the Mayo benign breast disease cohort to develop and validate a model of BC risk prediction that is specifically for women with AH, which we have designated as AH-BC. Patients and Methods Retrospective cohorts of women age 18 to 85 years with pathologically confirmed benign AH from Rochester, MN, and Nashville, TN, were used for model development and external validation, respectively...
April 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29675161/site-selective-18-f-fluorination-of-unactivated-c-h-bonds-mediated-by-a-manganese-porphyrin
#6
Wei Liu, Xiongyi Huang, Michael S Placzek, Shane W Krska, Paul McQuade, Jacob M Hooker, John T Groves
The first direct C-H 18 F fluorination reaction of unactivated aliphatic sites using no-carrier-added [18 F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C-H bonds can be selectively converted to C-18 F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of 18 F labeled radio tracers...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674264/ultrasonic-modulation-of-neural-circuit-activity
#7
REVIEW
William J Tyler, Shane W Lani, Grace M Hwang
Ultrasound (US) is recognized for its use in medical imaging as a diagnostic tool. As an acoustic energy source, US has become increasingly appreciated over the past decade for its ability to non-invasively modulate cellular activity including neuronal activity. Data obtained from a host of experimental models has shown that low-intensity US can reversibly modulate the physiological activity of neurons in peripheral nerves, spinal cord, and intact brain circuits. Experimental evidence indicates that acoustic pressures exerted by US act, in part, on mechanosensitive ion channels to modulate activity...
April 16, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29674190/urinary-angiotensinogen-excretion-in-australian-indigenous-and-non-indigenous-pregnant-women
#8
Kirsty G Pringle, Celine Corbisier de Meaultsart, Shane D Sykes, Loretta J Weatherall, Lyniece Keogh, Don C Clausen, Gus A Dekker, Roger Smith, Claire T Roberts, Kym M Rae, Eugenie R Lumbers
The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal disease, we hypothesised that Indigenous Australian pregnant women, like non-Indigenous women with pregnancy complications, would have altered uAGT levels. The excretion of RAS proteins was measured in non-Indigenous and Indigenous Australian women with uncomplicated or complicated pregnancies (preeclampsia, diabetes/gestational diabetes, proteinuria/albuminuria, hypertension, small/large for gestational age, preterm birth), and in non-pregnant non-Indigenous women...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673875/intervention-strategies-to-improve-nutrition-and-health-behaviours-before-conception
#9
REVIEW
Mary Barker, Stephan U Dombrowski, Tim Colbourn, Caroline H D Fall, Natasha M Kriznik, Wendy T Lawrence, Shane A Norris, Gloria Ngaiza, Dilisha Patel, Jolene Skordis-Worrall, Falko F Sniehotta, Régine Steegers-Theunissen, Christina Vogel, Kathryn Woods-Townsend, Judith Stephenson
The nutritional status of both women and men before conception has profound implications for the growth, development, and long-term health of their offspring. Evidence of the effectiveness of preconception interventions for improving outcomes for mothers and babies is scarce. However, given the large potential health return, and relatively low costs and risk of harm, research into potential interventions is warranted. We identified three promising strategies for intervention that are likely to be scalable and have positive effects on a range of health outcomes: supplementation and fortification; cash transfers and incentives; and behaviour change interventions...
April 16, 2018: Lancet
https://www.readbyqxmd.com/read/29673819/a-review-of-the-treatment-of-gunshot-wounds-to-the-head-in-the-late-19-th-century
#10
REVIEW
Matthew Protas, Emre Yilmaz, Patel Ap, Joe Iwanaga, Rod J Oskouian, R Shane Tubbs
No abstract text is available yet for this article.
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29673339/different-adiposity-indices-and-their-association-with-blood-pressure-and-hypertension-in-middle-aged-urban-black-south-african-men-and-women-findings-from-the-awi-gen-south-african-soweto-site
#11
Pedro T Pisa, Lisa K Micklesfield, Juliana Kagura, Michele Ramsay, Nigel J Crowther, Shane A Norris
BACKGROUND: To report associations between different adiposity indices [anthropometric and dual-energy X-ray absorptiometry (DXA) measures] and blood pressure (BP) and hypertension in urban black South African adults. METHODS: Anthropometric and DXA whole body measures were performed on 1026 men and 982 women. Participants were classified as being hypertensive if they had a systolic BP (SBP) ≥ 140 mmHg and/or diastolic (DBP) ≥ 90 mmHg. Within each gender the relationship of adiposity with BP and hypertension risk was assessed using linear and logistic regression models respectively...
April 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29672865/dietary-iron-fortification-normalizes-fetal-hematology-hepcidin-and-iron-distribution-in-a-rat-model-of-prenatal-alcohol-exposure
#12
Shane M Huebner, Kaylee K Helfrich, Nipun Saini, Sharon E Blohowiak, Adrienne A Cheng, Pamela J Kling, Susan M Smith
BACKGROUND: Prenatal alcohol exposure (PAE) causes neurodevelopmental disability. Clinical and animal studies show gestational iron deficiency exacerbates PAE's behavioral and growth deficits. In rat, PAE manifests an inability to establish iron homeostasis, increasing hepcidin (maternal and fetal) and fetal liver iron while decreasing brain iron and promoting anemia. Here, we hypothesize dietary iron fortification during pregnancy may mitigate alcohol's disruption of fetal iron homeostasis...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29671860/future-directions-in-disseminating-research-findings-to-urban-alaska-native-people
#13
Aliassa L Shane, Charlene R Apok, Michael J Doyle, Vanessa Y Hiratsuka, Denise A Dillard, Karen Caindec
Southcentral Foundation (SCF), a tribal health organization based in Anchorage, Alaska, operates and plans health care services in response to the priorities and tribal values of Alaska Native and American Indian (AN/AI) people, including traditional concepts of wellness, reciprocity, and working in relationship. In an effort to better incorporate AN/AI priorities and values in research dissemination, the SCF Research Department hosted the Alaska Native Health Research Forum (Forum) in May 2016. In this paper, we describe the communication strategies used by the SCF Public Relations Department, which were shared with Forum attendees, describe attendee recommendations for researchers to consider and implement, and then discuss future directions for dissemination...
2018: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
https://www.readbyqxmd.com/read/29670780/syphilis-related-eye-disease-presenting-as-bilateral-papilledema-retinal-nerve-fiber-layer-hemorrhage-and-anterior-uveitis-in-a-penicillin-allergic-patient
#14
Jamie Dietze, Shane Havens
Purpose . Treponema pallidum is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Human immunodeficiency virus (HIV) is known to expedite the progression of syphilis when patients are coinfected, thus compounding the potential ophthalmic presentations...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29669782/the-respiratory-environment-diverts-the-development-of-antiviral-memory-cd8-t-cells
#15
Hillary L Shane, Katie L Reagin, Kimberly D Klonowski
Our understanding of memory CD8+ T cells has been largely derived from acute, systemic infection models. However, memory CD8+ T cells generated from mucosal infection exhibit unique properties and, following respiratory infection, are not maintained in the lung long term. To better understand how infection route modifies memory differentiation, we compared murine CD8+ T cell responses to a vesicular stomatitis virus (VSV) challenge generated intranasally (i.n.) or i.v. The i.n. infection resulted in greater peak expansion of VSV-specific CD8+ T cells...
April 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29669249/the-transcription-factor-runx3-establishes-chromatin-accessibility-of-cis-regulatory-landscapes-that-drive-memory-cytotoxic-t-lymphocyte-formation
#16
Dapeng Wang, Huitian Diao, Adam J Getzler, Walter Rogal, Megan A Frederick, Justin Milner, Bingfei Yu, Shane Crotty, Ananda W Goldrath, Matthew E Pipkin
T cell receptor (TCR) stimulation of naive CD8+ T cells initiates reprogramming of cis-regulatory landscapes that specify effector and memory cytotoxic T lymphocyte (CTL) differentiation. We mapped regions of hyper-accessible chromatin in naive cells during TCR stimulation and discovered that the transcription factor (TF) Runx3 promoted accessibility to memory CTL-specific cis-regulatory regions before the first cell division and was essential for memory CTL differentiation. Runx3 was specifically required for accessibility to regions highly enriched with IRF, bZIP and Prdm1-like TF motifs, upregulation of TFs Irf4 and Blimp1, and activation of fundamental CTL attributes in early effector and memory precursor cells...
April 17, 2018: Immunity
https://www.readbyqxmd.com/read/29667838/general-synthetic-strategy-for-libraries-of-supported-multicomponent-metal-nanoparticles
#17
Hui Yang, Siobhan J Bradley, Xin Wu, Andrew Chan, Geoffrey I N Waterhouse, Thomas Nann, Jian Zhang, Paul E Kruger, Shengqian Ma, Shane G Telfer
Nanoparticles comprising three or more different metals are challenging to prepare. General methods that tackle this challenge are highly sought after as multicomponent metal nanoparticles display favorable properties in applications such as catalysis, biomedicine, and imaging. Herein, we report a practical and versatile approach for the synthesis of nanoparticles composed of up to four different metals. This method relies on the thermal decomposition of nanostructured composite materials assembled from platinum nanoparticles, a metal-organic framework (ZIF-8), and a tannic acid coordination polymer...
April 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29666777/injury-of-the-radial-nerve-in-the-arm-a-review
#18
REVIEW
Taroob J Latef, Muhammad Bilal, Marc Vetter, Joe Iwanaga, Rod J Oskouian, R Shane Tubbs
Compression of the radial nerve is most commonly described at the supinator muscle (i.e., arcade of Frohse). However, radial nerve compression can occur in the arm. Therefore, the purpose of this article is to review both etiologies of radial nerve entrapment and the sites at which this can occur in the arm. The clinical presentation of radial nerve entrapment in the arm and how it differs from that of entrapment at other sites is reviewed and the conditions potentially predisposing to nerve entrapment are described...
February 16, 2018: Curēus
https://www.readbyqxmd.com/read/29666412/extensive-t-cell-cross-reactivity-between-diverse-seasonal-influenza-strains-in-the-ferret-model
#19
Adrian J Reber, Nedzad Music, Jin Hyang Kim, Shane Gansebom, Jufu Chen, Ian York
Influenza virus causes widespread, yearly epidemics by accumulating surface protein mutations to escape neutralizing antibodies established from prior exposure. In contrast to antibody epitopes, T cell mediated immunity targets influenza epitopes that are more highly conserved and have potential for cross-protection. The extent of T cell cross-reactivity between a diverse array of contemporary and historical influenza strains was investigated in ferrets challenged with 2009 pandemic H1N1 influenza or the seasonal H3N2 strain, A/Perth/16/2009...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665491/methamphetamine-use-and-future-risk-for-parkinson-s-disease-evidence-and-clinical-implications
#20
REVIEW
Julia M Lappin, Shane Darke, Michael Farrell
BACKGROUND: Methamphetamine use has been posited to be a risk factor for the development of Parkinson's disease (PD) and parkinsonism. The clinical implications of a potential association between methamphetamine use and PD are considered. METHODS: A review of methamphetamine and PD and parkinsonism was conducted, including evidence from animal models, clinical and population studies. RESULTS: There is biological plausibility to a link between methamphetamine use and PD...
April 10, 2018: Drug and Alcohol Dependence
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