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Chris Powers

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https://www.readbyqxmd.com/read/29456285/improved-power-and-long-term-performance-of-microbial-fuel-cell-with-fe-n-c-catalyst-in-air-breathing-cathode
#1
Iwona Gajda, John Greenman, Carlo Santoro, Alexey Serov, Chris Melhuish, Plamen Atanassov, Ioannis A Ieropoulos
Power output limitation is one of the main challenges that needs to be addressed for full-scale applications of the Microbial Fuel Cell (MFC) technology. Previous studies have examined electrochemical performance of different cathode electrodes including the development of novel iron based electrocatalysts, however the long-term investigation into continuously operating systems is rare. This work aims to study the application of platinum group metals-free (PGM-free) catalysts integrated into an air-breathing cathode of the microbial fuel cell operating on activated sewage sludge and supplemented with acetate as the carbon energy source...
February 1, 2018: Energy: Technologies, Resources, Reserves, Demands, Impact, Conservation, Management, Policy
https://www.readbyqxmd.com/read/29453304/protocol-investigating-the-clinical-utility-of-an-objective-measure-of-attention-impulsivity-and-activity-qbtest-for-optimising-medication-management-in-children-and-young-people-with-adhd-qbtest-utility-for-optimising-treatment-in-adhd-quota-a-feasibility
#2
Charlotte L Hall, Marilyn James, Sue Brown, Jennifer L Martin, Nikki Brown, Kim Selby, Julie Clarke, Hena Vijayan, Boliang Guo, Kapil Sayal, Chris Hollis, Madeleine J Groom
INTRODUCTION: Attention-deficit hyperactivity disorder (ADHD) is characterised by symptoms of inattention, hyperactivity and impulsivity. To improve outcomes, the National Institute for Health and Care Excellence ADHD guidelines recommend regular monitoring of symptoms when children commence medication. However, research suggests that routine monitoring rarely happens, and clinicians often rely on subjective information such as reports from parents and teachers to ascertain improvement...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29435161/nonlinear-mixed-effects-dose-response-modeling-in-high-throughput-drug-screens-application-to-melanoma-cell-line-analysis
#3
Kuan-Fu Ding, Emanuel F Petricoin, Darren Finlay, Hongwei Yin, William P D Hendricks, Chris Sereduk, Jeffrey Kiefer, Aleksandar Sekulic, Patricia M LoRusso, Kristiina Vuori, Jeffrey M Trent, Nicholas J Schork
Cancer cell lines are often used in high throughput drug screens (HTS) to explore the relationship between cell line characteristics and responsiveness to different therapies. Many current analysis methods infer relationships by focusing on one aspect of cell line drug-specific dose-response curves (DRCs), the concentration causing 50% inhibition of a phenotypic endpoint (IC50). Such methods may overlook DRC features and do not simultaneously leverage information about drug response patterns across cell lines, potentially increasing false positive and negative rates in drug response associations...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29422951/impact-of-regionalisation-of-a-national-rheumatic-heart-disease-registry-the-ugandan-experience
#4
Emmy Okello, Chris T Longenecker, Amy Scheel, Twalib Aliku, Joselyn Rwebembera, Grace Mirembe, Craig Sable, Peter Lwabi, Andrea Beaton
Objectives: Rheumatic heart disease (RHD) remains a major driver of cardiovascular morbidity and mortality in low-resource settings. Registry-based care for RHD has been advocated as a powerful tool to improve clinical care and track quality metrics. Data collected through an RHD registry may also reveal epidemiological and geospatial trends, as well as insight into care utilisation. Uganda established a central RHD registry at the country's only tertiary cardiac centre in 2010. In 2014 RHD care and registry enrolment expanded to the Western region and in 2015 to the North...
2018: Heart Asia
https://www.readbyqxmd.com/read/29417833/clinical-response-to-treatment-in-inpatients-with-depression-correlates-with-changes-in-activity-levels-and-psychomotor-speed
#5
Ian Re Averill, Marie Crowe, Chris M Frampton, Ben Beaglehole, Cameron J Lacey, Jennifer Jordan, Lynere D Wilson, Katie M Douglas, Richard J Porter
BACKGROUND: Monitoring clinical response to treatment in depressed inpatients, particularly identifying early improvement, may be sub-optimal. This may impact adversely on patients through longer admissions and sub-optimal pharmacotherapy. Psychomotor speed is a prominent neuropsychological function which changes as recovery occurs. This study examines simple techniques used to quantify psychomotor change and their potential to contribute to monitoring recovery. METHODS: Activity levels were continuously monitored in patients diagnosed with a major depressive episode from four acute psychiatric wards using two actigraphs (commercial and scientific) for 3 weeks and linear regression used to calculate a gradient to express rate of change...
February 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29400863/broadband-bright-twin-beams-and-their-upconversion
#6
Maria V Chekhova, Semen Germanskiy, Dmitri B Horoshko, Galiya Kh Kitaeva, Mikhail I Kolobov, Gerd Leuchs, Chris R Phillips, Pavel A Prudkovskii
We report on the observation of broadband (40 THz) bright twin beams through high-gain parametric downconversion in an aperiodically poled lithium niobate crystal. The output photon number is shown to scale exponentially with the pump power and not with the pump amplitude, as in homogeneous crystals. Photon number correlations and the number of frequency/temporal modes are assessed by spectral covariance measurements. By using sum-frequency generation on the surface of a non-phase-matched crystal, we measure a cross-correlation peak with the temporal width of 90 fs...
February 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29390789/pressurized-transient-otoacoustic-emissions-measured-using-click-and-chirp-stimuli
#7
Douglas H Keefe, M Patrick Feeney, Lisa L Hunter, Denis F Fitzpatrick, Chris A Sanford
Transient-evoked otoacoustic emission (TEOAE) responses were measured in normal-hearing adult ears over frequencies from 0.7 to 8 kHz, and analyzed with reflectance/admittance data to measure absorbed sound power and the tympanometric peak pressure (TPP). The mean TPP was close to ambient. TEOAEs were measured in the ear canal at ambient pressure, TPP, and fixed air pressures from 150 to -200 daPa. Both click and chirp stimuli were used to elicit TEOAEs, in which the incident sound pressure level was constant across frequency...
January 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29387458/natriuretic-peptide-based-screening-and-prevention-of-heart-failure
#8
Joe Gallagher, Chris Watson, Patricia Campbell, Mark Ledwidge, Kenneth McDonald
There is increasing interest in the concept of personalised medicine, whereby conditions with common pathophysiologies are targeted together, and also using biomarkers to identify patients who will most benefit from certain interventions. Several data sets indicate that natriuretic peptides are effective in refining risk prediction for heart failure and cardiovascular disease and add predictive power to conventional risk factors. To date two trials have tested the approach of using natriuretic peptides as part of a strategy to identify those at highest risk of cardiovascular events: St...
November 2017: Cardiac Failure Review
https://www.readbyqxmd.com/read/29384838/probiotics-for-preterm-infants-a-strain-specific-systematic-review-and-network-meta-analysis
#9
Chris H P van den Akker, Johannes B van Goudoever, Hania Szajewska, Nicholas D Embleton, Iva Hojsak, Daan Reid, Raanan Shamir
OBJECTIVES: Several randomised controlled trials (RCTs) on the use of probiotics to reduce morbidity and mortality in preterm infants have provided inconsistent results. Whilst meta-analyses that group all of the used strains together, suggest efficacy, it is not possible to determine the most effective strain which is more relevant to the clinician. We therefore used a network meta-analysis (NMA) approach in order to identify strains with greatest efficacy. METHODS: A PubMed search identified placebo-controlled or head-to-head RCTs investigating probiotics in preterm infants...
January 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29380957/pilot-study-an-acute-bout-of-high-intensity-interval-exercise-increases-12-5%C3%A2-h-gh-secretion
#10
Sarah E Deemer, Todd J Castleberry, Chris Irvine, Daniel E Newmire, Michael Oldham, George A King, Vic Ben-Ezra, Brian A Irving, Kyle D Biggerstaff
The purpose of this study was to test the hypothesis that high-intensity interval exercise (HIE) significantly increases growth hormone (GH) secretion to a greater extent than moderate-intensity continuous exercise (MOD) in young women. Five young, sedentary women (mean ± SD; age: 22.6±1.3 years; BMI: 27.4±3.1 kg/m2 ) were tested during the early follicular phase of their menstrual cycle on three occasions. For each visit, participants reported to the laboratory at 1700 h, exercised from 1730-1800 h, and remained in the laboratory until 0700 h the following morning...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29377156/guided-undersampling-classification-for-automated-radiation-therapy-quality-assurance-of-prostate-cancer-treatment
#11
W Eric Brown, Kisuk Sung, Dionne M Aleman, Erick Moreno-Centeno, Thomas G Purdie, Chris J McIntosh
PURPOSE: To test the use of well-studied and widely used classification methods alongside newly developed data filtering techniques specifically designed for imbalanced-data classification in order to demonstrate proof of principle for an automated radiation therapy (RT) quality assurance process on prostate cancer treatment. METHODS: A series of acceptable (majority class, n = 61) and erroneous (minority class, n = 12) RT plans as well as a disjoint set of acceptable plans used to develop features (n = 273) were used to develop a data set for testing...
January 29, 2018: Medical Physics
https://www.readbyqxmd.com/read/29373431/the-importance-of-strength-and-power-on-key-performance-indicators-in-elite-youth-soccer
#12
Christopher E Wing, Anthony N Turner, Chris J Bishop
The purpose of this investigation was to examine the importance of strength and power in relation to key performance indicators (KPI's) within competitive soccer match play. This was achieved through using an experimental approach where fifteen subjects were recruited from a professional soccer club's scholarship squad during the 2013/14 season. Following anthropometric measures, power and strength were assessed across a range of tests which included the squat jump (SJ), countermovement jump (CMJ), 20 metre (m) sprint and arrowhead change of direction test...
January 24, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29361034/exploring-dna-variant-segregation-types-in-pooled-genome-sequencing-enables-effective-mapping-of-weeping-trait-in-malus
#13
Laura Dougherty, Raksha Singh, Susan Brown, Chris Dardick, Kenong Xu
To unlock the power of next generation sequencing-based bulked segregant analysis in allele discovery in out-crossing woody species, and to understand the genetic control of weeping trait, an F1 population from cross 'Cheal's Weeping' × 'Evereste' was used to create two genomic DNA pools 'weeping (17 progeny)' and 'standard (16 progeny)'. Illumina pair-end (2x151bp) sequencing of the pools to a 27.1x (weeping) and a 30.4x (standard) genome (742.3Mb) coverage allowed detection of 84,562 DNA variants specific to 'weeping', 92,148 specific to 'standard' and 173,169 common to both pools...
January 18, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29357865/-deathbedlive-the-end-of-life-trajectory-reflected-in-a-cancer-patient-s-tweets
#14
Joanna Taylor, Claudia Pagliari
BACKGROUND: Understanding physical and psycho-social illness trajectories towards the end of life can help in the planning of palliative and supportive care. With terminal patients increasingly seeking and sharing health information and support via social media, it is timely to examine whether these trajectories are reflected in their digital narratives. In this exploratory study, we analysed the Twitter feed of prominent cancer sufferer and physician, Kate Granger, over the final 6 months of her life...
January 22, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29356948/effect-of-dietary-nitrate-supplementation-on-thermoregulatory-and-cardiovascular-responses-to-submaximal-cycling-in-the-heat
#15
Georgina L Kent, Brian Dawson, Gregory R Cox, Chris R Abbiss, Kurt J Smith, Kevin D Croft, Zi Xiang Lim, Annette Eastwood, Louise M Burke, Peter Peeling
PURPOSE: This study investigated whether reported improvements in blood flow distribution, and the possible related effects on thermoregulation during exercise following supplementation with beetroot juice (BR), a rich source of dietary nitrate (NO3-), are mitigated in the heat. METHODS: 12 male endurance-trained cyclists (age 27 ± 6 years, VO2peak 68.6 ± 8.1 ml kg-1 min-1) completed two 60 min submaximal cycling trials at 60% of VO2peak power output...
March 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29354647/guidelines-and-recommendations-on-yeast-cell-death-nomenclature
#16
REVIEW
Didac Carmona-Gutierrez, Maria Anna Bauer, Andreas Zimmermann, Andrés Aguilera, Nicanor Austriaco, Kathryn Ayscough, Rena Balzan, Shoshana Bar-Nun, Antonio Barrientos, Peter Belenky, Marc Blondel, Ralf J Braun, Michael Breitenbach, William C Burhans, Sabrina Büttner, Duccio Cavalieri, Michael Chang, Katrina F Cooper, Manuela Côrte-Real, Vítor Costa, Christophe Cullin, Ian Dawes, Jörn Dengjel, Martin B Dickman, Tobias Eisenberg, Birthe Fahrenkrog, Nicolas Fasel, Kai-Uwe Fröhlich, Ali Gargouri, Sergio Giannattasio, Paola Goffrini, Campbell W Gourlay, Chris M Grant, Michael T Greenwood, Nicoletta Guaragnella, Thomas Heger, Jürgen Heinisch, Eva Herker, Johannes M Herrmann, Sebastian Hofer, Antonio Jiménez-Ruiz, Helmut Jungwirth, Katharina Kainz, Dimitrios P Kontoyiannis, Paula Ludovico, Stéphen Manon, Enzo Martegani, Cristina Mazzoni, Lynn A Megeney, Chris Meisinger, Jens Nielsen, Thomas Nyström, Heinz D Osiewacz, Tiago F Outeiro, Hay-Oak Park, Tobias Pendl, Dina Petranovic, Stephane Picot, Peter Polčic, Ted Powers, Mark Ramsdale, Mark Rinnerthaler, Patrick Rockenfeller, Christoph Ruckenstuhl, Raffael Schaffrath, Maria Segovia, Fedor F Severin, Amir Sharon, Stephan J Sigrist, Cornelia Sommer-Ruck, Maria João Sousa, Johan M Thevelein, Karin Thevissen, Vladimir Titorenko, Michel B Toledano, Mick Tuite, F-Nora Vögtle, Benedikt Westermann, Joris Winderickx, Silke Wissing, Stefan Wölfl, Zhaojie J Zhang, Richard Y Zhao, Bing Zhou, Lorenzo Galluzzi, Guido Kroemer, Frank Madeo
Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel-lular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the defi-nition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria...
January 1, 2018: Microbial Cell
https://www.readbyqxmd.com/read/29350916/rhombohedral-to-cubic-conversion-of-gete-via-mnte-alloying-leads-to-ultralow-thermal-conductivity-electronic-band-convergence-and-high-thermoelectric-performance
#17
Zheng Zheng, Xianli Su, Rigui Deng, Constantinos C Stoumpos, Hongyao Xie, Wei Liu, Yonggao Yan, Shiqiang Hao, Ctirad Uher, Chris Wolverton, Mercouri G Kanatzidis, Xinfeng Tang
In this study, a series of Ge1-xMnxTe (x=0-0.21) compounds were prepared by melting-quenching-annealing process combined with Spark Plasma Sintering (SPS). The effect of alloying MnTe into GeTe on the structure and thermoelectric properties of Ge1-xMnxTe is profound. With increasing content of MnTe, the structure of the Ge1-xMnxTe compounds gradually changes from rhombohedral to cubic, and the known R3m to Fm-3m phase transition temperature of GeTe moves from 700 K closer to room temperature. First-principles density functional theory calculations show that alloying MnTe into GeTe decreases the energy difference between the light and heavy valence bands in both the R3m and the Fm-3m structures, enhancing a multi-band character of the valence band edge that increases the hole carrier effective mass...
January 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29346087/a-not-for-profit-regulatory-model-for-legal-recreational-cannabis-insights-from-the-regulation-of-gaming-machine-gambling-in-new-zealand
#18
Chris Wilkins
A dozen or more regulatory frameworks have been proposed for legal cannabis but many of the "not-for-profit" options have yet to be developed in any detail, reducing the likelihood they will be seriously considered by policy makers. New Zealand's innovative "not-for-profit" regulatory regime for gaming machine gambling (i.e. "slot machines") has reversed the previous increase in gambling expenditure, empowered local councils to cap the number of gambling venues, and is unique in requiring the societies operating gaming machines to distribution 40% of the gross expenditure from machines (i...
January 12, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29343764/genome-wide-association-study-in-79-366-european-ancestry-individuals-informs-the-genetic-architecture-of-25-hydroxyvitamin-d-levels
#19
Xia Jiang, Paul F O'Reilly, Hugues Aschard, Yi-Hsiang Hsu, J Brent Richards, Josée Dupuis, Erik Ingelsson, David Karasik, Stefan Pilz, Diane Berry, Bryan Kestenbaum, Jusheng Zheng, Jianan Luan, Eleni Sofianopoulou, Elizabeth A Streeten, Demetrius Albanes, Pamela L Lutsey, Lu Yao, Weihong Tang, Michael J Econs, Henri Wallaschofski, Henry Völzke, Ang Zhou, Chris Power, Mark I McCarthy, Erin D Michos, Eric Boerwinkle, Stephanie J Weinstein, Neal D Freedman, Wen-Yi Huang, Natasja M Van Schoor, Nathalie van der Velde, Lisette C P G M de Groot, Anke Enneman, L Adrienne Cupples, Sarah L Booth, Ramachandran S Vasan, Ching-Ti Liu, Yanhua Zhou, Samuli Ripatti, Claes Ohlsson, Liesbeth Vandenput, Mattias Lorentzon, Johan G Eriksson, M Kyla Shea, Denise K Houston, Stephen B Kritchevsky, Yongmei Liu, Kurt K Lohman, Luigi Ferrucci, Munro Peacock, Christian Gieger, Marian Beekman, Eline Slagboom, Joris Deelen, Diana van Heemst, Marcus E Kleber, Winfried März, Ian H de Boer, Alexis C Wood, Jerome I Rotter, Stephen S Rich, Cassianne Robinson-Cohen, Martin den Heijer, Marjo-Riitta Jarvelin, Alana Cavadino, Peter K Joshi, James F Wilson, Caroline Hayward, Lars Lind, Karl Michaëlsson, Stella Trompet, M Carola Zillikens, Andre G Uitterlinden, Fernando Rivadeneira, Linda Broer, Lina Zgaga, Harry Campbell, Evropi Theodoratou, Susan M Farrington, Maria Timofeeva, Malcolm G Dunlop, Ana M Valdes, Emmi Tikkanen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Mika Kähönen, Olli T Raitakari, Vera Mikkilä, M Arfan Ikram, Naveed Sattar, J Wouter Jukema, Nicholas J Wareham, Claudia Langenberg, Nita G Forouhi, Thomas E Gundersen, Kay-Tee Khaw, Adam S Butterworth, John Danesh, Timothy Spector, Thomas J Wang, Elina Hyppönen, Peter Kraft, Douglas P Kiel
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC23A, and P = 1...
January 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29336946/ldl-cholesterol-how-low-to-go
#20
REVIEW
Chris J Packard
Epidemiology and the results of large-scale outcome trials indicate that the association of LDL with atherosclerotic cardiovascular disease is causal, and continuous not only across levels seen in the general population but also down to sub-physiological values. There is no scientific basis, therefore, to set a target or 'floor' for LDL cholesterol lowering, and this presents a clinical and conceptual dilemma for prescribers, patients, and payers. With the advent of powerful agents such as proprotein convertase/subtilisin kexin type 9 (PCSK9) inhibitors, LDL cholesterol can be lowered profoundly but health economic constraints mandate that this therapeutic approach needs to be selective...
December 28, 2017: Trends in Cardiovascular Medicine
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