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Chris Powers

Chris Jeynes, Julien L Colaux
The analysis of thin films is of central importance for functional materials, including the very large and active field of nanomaterials. Quantitative elemental depth profiling is basic to analysis, and many techniques exist, but all have limitations and quantitation is always an issue. We here review recent significant advances in ion beam analysis (IBA) which now merit it a standard place in the analyst's toolbox. Rutherford backscattering spectrometry (RBS) has been in use for half a century to obtain elemental depth profiles non-destructively from the first fraction of a micron from the surface of materials: more generally, "IBA" refers to the cluster of methods including elastic scattering (RBS; elastic recoil detection, ERD; and non-Rutherford elastic backscattering, EBS), nuclear reaction analysis (NRA: including particle-induced gamma-ray emission, PIGE), and also particle-induced X-ray emission (PIXE)...
October 17, 2016: Analyst
Roz G Brant, Alan Sharpe, Tom Liptrot, Jonathan Dry, Elizabeth A Harrington, J Carl Barrett, Nicky Whalley, Chris Womack, Paul D Smith, Darren Hodgson
PURPOSE: To develop a clinically viable gene expression assay to measure RAS/RAF/MEK/ERK (RAS-ERK) pathway output suitable for hypothesis testing in non-small cell lung cancer (NSCLC) clinical studies. EXPERIMENTAL DESIGN: A published MEK-functional-activation signature (MEK signature) that measures RAS-ERK functional output was optimized for NSCLC in silico. NanoString assays were developed for the NSCLC optimized MEK signature and the 147-gene RAS signature. First, platform transfer from Affymetrix to NanoString, and signature modulation following treatment with KRAS siRNA and MEK inhibitor, were investigated in cell lines...
October 12, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Chris A Hamilton, Alan R Lemmon, Emily Moriarty Lemmon, Jason E Bond
BACKGROUND: Despite considerable effort, progress in spider molecular systematics has lagged behind many other comparable arthropod groups, thereby hindering family-level resolution, classification, and testing of important macroevolutionary hypotheses. Recently, alternative targeted sequence capture techniques have provided molecular systematics a powerful tool for resolving relationships across the Tree of Life. One of these approaches, Anchored Hybrid Enrichment (AHE), is designed to recover hundreds of unique orthologous loci from across the genome, for resolving both shallow and deep-scale evolutionary relationships within non-model systems...
October 13, 2016: BMC Evolutionary Biology
Carlos A Camillo, Christian R Osadnik, Hans van Remoortel, Chris Burtin, Wim Janssens, Thierry Troosters
The aim of this review was to identify the effectiveness of therapies added on to conventional exercise training to maximise exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Electronic databases were searched, identifying trials comparing exercise training with exercise training plus "add-on" therapy. Outcomes included peak oxygen uptake (V'O2peak), work rate and incremental/endurance cycle and field walking tests. Individual trial effects on exercise capacity were extracted and collated into eight subgroups and pooled for meta-analysis...
January 2016: ERJ Open Research
Tamara Kramer, Barbara Ch Huijgen, Marije T Elferink-Gemser, Chris Visscher
PURPOSE: To analyze how physical fitness (PF) improves in elite junior tennis players related to age, maturity, and performance level. METHODS: Elite junior tennis players (n=113 boys, n=83 girls) divided by performance level were monitored longitudinally from U14 to U16. Maturity, upper and lower body power, speed, and agility were measured during subsequent competitive seasons. Improvement was analyzed per sex using multilevel analysis. RESULTS: PF components for boys and girls improved over age (U14-U16) (ES ...
October 5, 2016: Pediatric Exercise Science
Chris Jackson, Eric D Salomaki, Christopher E Lane, Gary W Saunders
If ever there were "charismatic megaflora" of the sea, the Laminariales (kelp) would undoubtedly meet that designation. From the Northeast Pacific kelp forests, to the less diverse but nonetheless dense kelp beds ranging from the Arctic to the cold temperate waters of the Southern Hemisphere, kelp provide habitat structure and food for a variety of productive marine systems. Consequently, kelp are well represented in the literature, however, understanding their evolution has proven challenging. We used a 152-gene phylogenomics approach to better resolve the phylogeny of the "derived" kelp families (viz...
October 5, 2016: Journal of Phycology
Iain C Macaulay, Mabel J Teng, Wilfried Haerty, Parveen Kumar, Chris P Ponting, Thierry Voet
Parallel sequencing of a single cell's genome and transcriptome provides a powerful tool for dissecting genetic variation and its relationship with gene expression. Here we present a detailed protocol for G&T-seq, a method for separation and parallel sequencing of genomic DNA and full-length polyA(+) mRNA from single cells. We provide step-by-step instructions for the isolation and lysis of single cells; the physical separation of polyA(+) mRNA from genomic DNA using a modified oligo-dT bead capture and the respective whole-transcriptome and whole-genome amplifications; and library preparation and sequence analyses of these amplification products...
November 2016: Nature Protocols
Lillian Ng, Chris Bampton, Seonaigh Stevens, Penny Woods
OBJECTIVE: The objective of this study was to describe the method and relevance of infant observation as a unique and powerful learning tool for psychiatrists. CONCLUSION: Infant observation provides a privileged entry into an infant's internal world to observe its earliest mental life. Weekly consecutive observations of the mother-baby dyad, combined with the process of supervision, enable identification of emergent and changing patterns in the relationship. The discipline of observation encourages attunement to the nuances of relationships, which provides a potent tool for application in other clinical settings...
September 27, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Heather Waterman, Claire Ballinger, Caroline Brundle, Sebastien Chastin, Heather Gage, Robert Harper, David Henson, Bob Laventure, Lisa McEvoy, Mark Pilling, Nicky Olleveant, Dawn A Skelton, Penelope Stanford, Chris Todd
BACKGROUND: Published evaluations of successful interventions to prevent falls in people with sight impairment (SI) are limited. The aim of this feasibility study is to optimise the design and investigation of home safety (HS) and home exercise (HE) programmes to prevent falls in older people with SI. METHODS: A community-based feasibility study in north-west England comprising a three-arm randomised controlled trial (RCT) allocated participants to (1) a control group receiving usual care and social visits, (2) an experimental group receiving the HS programme and (3) an experimental group receiving the HS + HE programme...
September 26, 2016: Trials
Aaron S Chou, Richard Gustafson, Craig Hogan, Brittany Kamai, Ohkyung Kwon, Robert Lanza, Lee McCuller, Stephan S Meyer, Jonathan Richardson, Chris Stoughton, Raymond Tomlin, Samuel Waldman, Rainer Weiss
Measurements are reported of the cross-correlation of spectra of differential position signals from the Fermilab Holometer, a pair of colocated 39 m long, high power Michelson interferometers with flat broadband frequency response in the MHz range. The instrument obtains sensitivity to high frequency correlated signals far exceeding any previous measurement in a broad frequency band extending beyond the 3.8 MHz inverse light-crossing time of the apparatus. The dominant but uncorrelated shot noise is averaged down over 2×10^{8} independent spectral measurements with 381 Hz frequency resolution to obtain 2...
September 9, 2016: Physical Review Letters
Hui C Choo, Kazunori Nosaka, Jeremiah J Peiffer, Mohammed Ihsan, Chow C Yeo, Chris R Abbiss
This study examined the test-retest reliability of near-infrared spectroscopy (NIRS), laser Doppler flowmetry (LDF) and Doppler ultrasound to assess exercise-induced haemodynamics. Nine men completed two identical trials consisting of 25-min submaximal cycling at first ventilatory threshold followed by repeated 30-s bouts of high-intensity (90% of peak power) cycling in 32.8 ± 0.4°C and 32 ± 5% relative humidity (RH). NIRS (tissue oxygenation index [TOI] and total haemoglobin [tHb]) and LDF (perfusion units [PU]) signals were monitored continuously during exercise, and leg blood flow was assessed by Doppler ultrasound at baseline and after exercise...
September 21, 2016: Journal of Sports Sciences
Paul Comfort, Amy Regan, Lee Herrington, Chris Thomas, John McMahon, Paul Jones
CONTEXT: Regular performance (~2 x week) of Nordic curls has been shown to increase hamstring strength and reduce the risk of hamstring strain injury, although no consensus on ankle position has been provided. OBJECTIVE: The aim of this study was to compare the effects of performing Nordic curls, with the ankle in a dorsiflexed (DF) or plantar flexed (PF) position, on muscle activity of the biceps femoris (BF) and medial gastrocnemius (MG). PARTICIPANTS: Fifteen (age 22...
August 24, 2016: Journal of Sport Rehabilitation
Julian Danino, Jameel Muzaffar, Chris Metcalfe, Chris Coulson
Human evaluation and judgement may include errors that can have disastrous results. Within medicine and healthcare there has been slow progress towards major changes in safety. Healthcare lags behind other specialised industries, such as aviation and nuclear power, where there have been significant improvements in overall safety, especially in reducing risk of errors. Following several high profile cases in the USA during the 1990s, a report titled "To Err Is Human: Building a Safer Health System" was published...
September 13, 2016: European Archives of Oto-rhino-laryngology
Irwani Ibrahim, Win Sen Kuan, Chris Frampton, Richard Troughton, Oi Wah Liew, Jenny Pek Ching Chong, Siew Pang Chan, Li Ling Tan, Wei Qin Lin, Chris J Pemberton, Shirley Beng Suat Ooi, A Mark Richards
AIMS: This study was conducted to test the diagnostic performance of NT-proBNP for discrimination of acute decompensated heart failure (ADHF) among breathless patients presenting in an Asian compared with a Western centre. METHODS AND RESULTS: Patients with breathlessness were prospectively and contemporaneously recruited in Emergency Departments in Singapore and New Zealand (NZ). The diagnosis of ADHF was adjudicated by two clinician specialists. A total of 606 patients were recruited in Singapore and 500 in NZ...
September 13, 2016: European Journal of Heart Failure
Zoe C L Pittman, Stephen G John, Chris W McIntyre
Introduction Patient reported outcomes (PROs) are a critical metric documenting the impact of disease and treatment from the patient's perspective. A variety of generic and disease specific PRO measures (PROMs) are used in chronic kidney disease (CKD) but studies are primarily cross-sectional. None of the available PROMs are designed for frequent iterative application. Methods An online PROM for daily use in dialysis and CKD 4/5 patients was developed. The custom website utilised visual analogue scales to capture 6 PROs (general well being (GWB), pain, sleep, breathing, energy, and appetite)...
September 12, 2016: Hemodialysis International
Isla S Mackenzie, Ian Ford, Andrew Walker, Chris Hawkey, Alan Begg, Anthony Avery, Jaspal Taggar, Li Wei, Allan D Struthers, Thomas M MacDonald
INTRODUCTION: Ischaemic heart disease (IHD) is one of the most common causes of death in the UK and treatment of patients with IHD costs the National Health System (NHS) billions of pounds each year. Allopurinol is a xanthine oxidase inhibitor used to prevent gout that also has several positive effects on the cardiovascular system. The ALL-HEART study aims to determine whether allopurinol improves cardiovascular outcomes in patients with IHD. METHODS AND ANALYSIS: The ALL-HEART study is a multicentre, controlled, prospective, randomised, open-label blinded end point (PROBE) trial of allopurinol (up to 600 mg daily) versus no treatment in a 1:1 ratio, added to usual care, in 5215 patients aged 60 years and over with IHD...
2016: BMJ Open
Sherri Ogston-Tuck, Kath Baume, Chris Clarke, Simon Heng
BACKGROUND: For decades film has proved to be a powerful form of communication. Whether produced as entertainment, art or documentary, films have the capacity to inform and move us. Films are a highly attractive teaching instrument and an appropriate teaching method in health education. It is a valuable tool for studying situations most transcendental to human beings such as pain, disease and death. OBJECTIVES: The objectives were to determine how this helps students engage with their role as health care professionals; to determine how they view the personal experience of illness, disease, disability or death; and to determine how this may impact upon their provision of patient care...
November 2016: Nurse Education Today
Cameron S McElroy, Elysia Min, Jie Huang, Joan E Loader, Tara B Hendry-Hofer, Rhonda B Garlick, Jackie S Rioux, Livia A Veress, Russell Smith, Chris Osborne, Dana R Anderson, Wesley W Holmes, Danielle C Paradiso, Carl W White, Brian J Day
Sulfur mustard (bis 2-chloroethyl ethyl sulfide, SM) is a powerful bi-functional vesicating chemical warfare agent. SM tissue injury is partially mediated by the overproduction of reactive oxygen species resulting in oxidative stress. We hypothesized that using a catalytic antioxidant (AEOL 10150) to alleviate oxidative stress and secondary inflammation following exposure to SM would attenuate the toxic effects of SM inhalation. Adult male rats were intubated and exposed to SM (1.4 mg/kg), a dose that produces an LD50 at approximately 24 h...
September 7, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
Carley Gasaway, Maria Mastalerz, Fed Krause, Chris Clarkson, Chris Debuhr
Samples of Late Devonian/Early Mississippian New Albany Shale from the Illinois Basin, having maturities ranging from early mature to postmature, were analysed using micro-Fourier transform infrared (FTIR) spectroscopy, ImageJ processing software and scanning electron microscopic X-ray spectroscopy to explore the distribution, connectivity and chemical composition of organic matter, clay minerals, carbonate minerals and quartz, and to further test the applicability of micro-FTIR mapping to study shale heterogeneity...
September 6, 2016: Journal of Microscopy
Jieun Lee, Mathias Wipf, Luye Mu, Chris Adams, Jennifer Hannant, Mark A Reed
We report a method to suppress streaming potential using an Ag-coated microfluidic channel on a p-type silicon nanowire (SiNW) array measured by a multiplexed electrical readout. The metal layer sets a constant electrical potential along the microfluidic channel for a given reference electrode voltage regardless of the flow velocity. Without the Ag layer, the magnitude and sign of the surface potential change on the SiNW depends on the flow velocity, width of the microfluidic channel and the device's location inside the microfluidic channel with respect to the reference electrode...
August 24, 2016: Biosensors & Bioelectronics
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