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Chris Powers

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https://www.readbyqxmd.com/read/28545574/initiating-change-locally-in-bullying-and-aggression-through-the-school-environment-inclusive-trial-update-to-cluster-randomised-controlled-trial-protocol
#1
Chris Bonell, Anne Mathiot, Elizabeth Allen, Leonardo Bevilacqua, Deborah Christie, Diana Elbourne, Adam Fletcher, Richard Grieve, Rosa Legood, Stephen Scott, Emily Warren, Meg Wiggins, Russell M Viner
BACKGROUND: Systematic reviews suggest that multi-component interventions are effective in reducing bullying victimisation and perpetration. We are undertaking a phase III randomised trial of the INCLUSIVE multi-component intervention. This trial aims to assess the effectiveness and cost-effectiveness of the INCLUSIVE intervention in reducing aggression and bullying victimisation in English secondary schools. This paper updates the original trial protocol published in 2014 (Trials 15:381, 2014) and presents the changes in the process evaluation protocol and the secondary outcome data collection...
May 25, 2017: Trials
https://www.readbyqxmd.com/read/28538318/do-fencers-require-a-weapon-specific-approach-to-strength-and-conditioning-training
#2
Anthony N Turner, Chris J Bishop, Jon A Cree, Michael L Edwards, Shyam Chavda, Paul J Read, David M J Kirby
Turner, AN, Bishop, CJ, Cree, JA, Edwards, ML, Chavda, S, Read, PJ, and Kirby, DMJ. Do fencers require a weapon-specific approach to strength and conditioning training? J Strength Cond Res 31(6): 1662-1668, 2017-There are 3 types of weapons used in Olympic fencing: the épée, foil, and sabre. The aim of this study was to determine if fencers exhibited different physical characteristics across weapons. Seventy-nine male (n = 46) and female (n = 33) national standard fencers took part in this study. Fencers from each weapon (male and female), i...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28533558/investigating-the-causal-effect-of-smoking-on-hay-fever-and-asthma-a-mendelian-randomization-meta-analysis-in-the-carta-consortium
#3
Tea Skaaby, Amy E Taylor, Rikke K Jacobsen, Lavinia Paternoster, Betina H Thuesen, Tarunveer S Ahluwalia, Sofus C Larsen, Ang Zhou, Andrew Wong, Maiken E Gabrielsen, Johan H Bjørngaard, Claudia Flexeder, Satu Männistö, Rebecca Hardy, Diana Kuh, Sarah J Barry, Line Tang Møllehave, Charlotte Cerqueira, Nele Friedrich, Tobias N Bonten, Raymond Noordam, Dennis O Mook-Kanamori, Christian Taube, Leon E Jessen, Alex McConnachie, Naveed Sattar, Mark N Upton, Charles McSharry, Klaus Bønnelykke, Hans Bisgaard, Holger Schulz, Konstantin Strauch, Thomas Meitinger, Annette Peters, Harald Grallert, Ellen A Nohr, Mika Kivimaki, Meena Kumari, Uwe Völker, Matthias Nauck, Henry Völzke, Chris Power, Elina Hyppönen, Torben Hansen, Torben Jørgensen, Oluf Pedersen, Veikko Salomaa, Niels Grarup, Arnulf Langhammer, Pål R Romundstad, Frank Skorpen, Jaakko Kaprio, Marcus R Munafò, Allan Linneberg
Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967)...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28508868/influence-of-age-and-eosinophilic-esophagitis-on-esophageal-distensibility-in-a-pediatric-cohort
#4
Calies Menard-Katcher, Alain J Benitez, Zhaoxing Pan, Faria N Ahmed, Benjamin J Wilkins, Kelley E Capocelli, Chris A Liacouras, Ritu Verma, Jonathan M Spergel, Glenn T Furuta, Amanda B Muir
OBJECTIVES: Sequelae of eosinophilic esophagitis (EoE) include food impaction and esophageal stricture. Duration of inflammation is a predicted risk factor; however, complications remain unpredictable. Studies using the functional lumen imaging probe (FLIP) have demonstrated decreased distensibility of the esophagus in adult patients with EoE. As the impact of inflammation on the developing esophagus is unknown, we investigated esophageal distensibility in a pediatric cohort to determine the effect of age, ongoing inflammation, and fibrotic features on distensibility...
May 16, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28500271/causal-associations-of-adiposity-and-body-fat-distribution-with-coronary-heart-disease-stroke-subtypes-and-type-2-diabetes-a-mendelian-randomization-analysis
#5
Caroline Dale, Ghazaleh Fatemifar, Tom Palmer, Jonathan White, David Prieto-Merino, Delilah Zabaneh, Jorgen E L Engmann, Tina Shah, Andrew Wong, Helen R Warren, Stela McLachlan, Stella Trompet, Max Moldovan, Richard W Morris, Reecha Sofat, Meena Kumari, Elina Hyppönen, Barbara J Jefferis, Tom R Gaunt, Yoav Ben-Shlomo, Ang Zhou, Aleksandra Gentry-Maharaj, Andy Ryan, Renée de Mutsert, Raymond Noordam, Mark J Caulfield, J Wouter Jukema, Bradford B Worrall, Patricia B Munroe, Usha Menon, Chris Power, Diana Kuh, Debbie A Lawlor, Steve E Humphries, Dennis O Mook-Kanamori, George Davey Smith, Naveed Sattar, Mika Kivimaki, Jacqueline F Price, Frank Dudbridge, Aroon D Hingorani, Michael V Holmes, Juan-Pablo Casas
Background -Implications of different adiposity measures on cardiovascular disease aetiology remain unclear. In this paper we quantify and contrast causal associations of central adiposity (waist:hip ratio adjusted for BMI (WHRadjBMI)) and general adiposity (body mass index (BMI)) with cardiometabolic disease. Methods -97 independent single nucleotide polymorphisms (SNPs) for BMI and 49 SNPs for WHRadjBMI were used to conduct Mendelian randomization analyses in 14 prospective studies supplemented with CHD data from CARDIoGRAMplusC4D (combined total 66,842 cases), stroke from METASTROKE (12,389 ischaemic stroke cases), type 2 diabetes (T2D) from DIAGRAM (34,840 cases), and lipids from GLGC (213,500 participants) consortia...
May 12, 2017: Circulation
https://www.readbyqxmd.com/read/28489547/a-172-mu-w-compressively-sampled-photoplethysmographic-ppg-readout-asic-with-heart-rate-estimation-directly-from-compressively-sampled-data
#6
Venkata Rajesh Pamula, Jose Manuel Valero-Sarmiento, Long Yan, Alper Bozkurt, Chris Van Hoof, Nick Van Helleputte, Refet Firat Yazicioglu, Marian Verhelst
A compressive sampling (CS) photoplethysmographic (PPG) readout with embedded feature extraction to estimate heart rate (HR) directly from compressively sampled data is presented. It integrates a low-power analog front end together with a digital back end to perform feature extraction to estimate the average HR over a 4 s interval directly from compressively sampled PPG data. The application-specified integrated circuit (ASIC) supports uniform sampling mode (1x compression) as well as CS modes with compression ratios of 8x, 10x, and 30x...
June 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28488792/comprehensive-database-of-manufactured-gas-plant-tars-part-a-database
#7
Christopher Gallacher, Russell Thomas, Richard Lord, Robert M Kalin, Chris Taylor
RATIONALE: Coal tars are a mixture of organic and inorganic compounds and were by-products from the manufactured gas and coke making industries. Different manufacturing processes have resulted in the production of distinctly different tar compositions. This study presents a comprehensive database of compounds produced using two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GCxGC/TOFMS), analysing 16 tar samples produced by 5 distinct production processes...
May 10, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28482762/power-training-in-chronic-stroke-individuals-differences-between-responders-and-nonresponders
#8
Stacey E Aaron, Jennifer L Hunnicutt, Aaron E Embry, Mark G Bowden, Chris M Gregory
BACKGROUND: Lower extremity muscle weakness is a primary contributor to post-stroke dysfunction. Resistance training is an effective treatment for hemiparetic weakness and improves walking performance. Post-stroke subject characteristics that do or do not improve walking speed following resistance training are unknown. OBJECTIVE: The purpose of this paper was to describe baseline characteristics, as well as responses to training, associated with achieving a minimal clinically important difference (MCID) in walking speed (≥0...
May 8, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28469750/the-effect-of-previous-wingate-performance-using-one-body-region-on-subsequent-wingate-performance-using-a-different-body-region
#9
Leonie Harvey, Matthew Bousson, Chris McLellan, Dale Lovell
The 30 second Wingate Anaerobic Test (WAnT) is the gold standard measure of anaerobic performance. The present investigation aimed to determine if a previous WAnT using one body region significantly affected a subsequent WAnT using a different body region. Twelve male university students (n = 12, 23 ± 2 years, 84 ± 16.1 kg, 178.5 ± 7.4 cm) volunteered to complete two repeated WAnT protocols (either lower body WAnT followed by an upper body WAnT or vice versa) on two separate testing occasions. The upper body WAnT was conducted on a modified electromagnetically braked cycle ergometer using a flywheel braking force corresponding to 5% bodyweight...
February 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28464384/higher-yields-and-lower-methane-emissions-with-new-rice-cultivars
#10
Yu Jiang, Kees Jan van Groenigen, Shan Huang, Bruce A Hungate, Chris van Kessel, Shuijin Hu, Jun Zhang, Lianhai Wu, Xiaojun Yan, Lili Wang, Jin Chen, Xiaoning Hang, Yi Zhang, William R Horwath, Rongzhong Ye, Bruce A Linquist, Zhenwei Song, Chengyan Zheng, Aixing Deng, Weijian Zhang
Breeding high-yielding rice cultivars through increasing biomass is a key strategy to meet rising global food demands. Yet, increasing rice growth can stimulate methane (CH4 ) emissions, exacerbating global climate change, as rice cultivation is a major source of this powerful greenhouse gas. Here, we show in a series of experiments that high-yielding rice cultivars actually reduce CH4 emissions from typical paddy soils. Averaged across 33 rice cultivars, a biomass increase of 10% resulted in a 10.3% decrease in CH4 emissions in a soil with a high carbon (C) content...
May 2, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28442585/next-gen-sequencing-analysis-and-algorithms-for-pdx-and-cdx-models
#11
Garima Khandelwal, Maria Romina Girotti, Christopher Smowton, Sam Taylor, Chris Wirth, Marek Dynowski, Kristopher K Frese, Ged Brady, Caroline Dive, Richard Marais, Crispin Miller
Patient-derived xenograft (PDX) and CTC-derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions including the study of metastatic progression, genetic evolution and therapeutic drug responses. Since PDX and CDX models can recapitulate the highly heterogeneous characteristics of a patient tumor, as well as their response to chemotherapy, there is considerable interest in combining them with next-generation sequencing (NGS) in order to monitor the genomic, transcriptional, and epigenetic changes that accompany oncogenesis...
April 25, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28422968/the-impact-of-a-point-of-care-testing-device-on-cvd-risk-assessment-completion-in-new-zealand-primary-care-practice-a-cluster-randomised-controlled-trial-and-qualitative-investigation
#12
RANDOMIZED CONTROLLED TRIAL
Sue Wells, Natasha Rafter, Timothy Kenealy, Geoff Herd, Kyle Eggleton, Rose Lightfoot, Kim Arcus, Angela Wadham, Yannan Jiang, Chris Bullen
OBJECTIVES: To assess the effect of a point of care (POC) device for testing lipids and HbA1c in addition to testing by community laboratory facilities (usual practice) on the completion of cardiovascular disease (CVD) risk assessments in general practice. METHODS: We conducted a pragmatic, cluster randomised controlled trial in 20 New Zealand general practices stratified by size and rurality and randomised to POC device plus usual practice or usual practice alone (controls)...
2017: PloS One
https://www.readbyqxmd.com/read/28422663/a-neural-probe-with-up-to-966-electrodes-and-up-to-384-configurable-channels-in-0-13-mu-m-soi-cmos
#13
Carolina Mora Lopez, Jan Putzeys, Bogdan Cristian Raducanu, Marco Ballini, Shiwei Wang, Alexandru Andrei, Veronique Rochus, Roeland Vandebriel, Simone Severi, Chris Van Hoof, Silke Musa, Nick Van Helleputte, Refet Firat Yazicioglu, Srinjoy Mitra
In vivo recording of neural action-potential and local-field-potential signals requires the use of high-resolution penetrating probes. Several international initiatives to better understand the brain are driving technology efforts towards maximizing the number of recording sites while minimizing the neural probe dimensions. We designed and fabricated (0.13- μm SOI Al CMOS) a 384-channel configurable neural probe for large-scale in vivo recording of neural signals. Up to 966 selectable active electrodes were integrated along an implantable shank (70 μm wide, 10 mm long, 20  μm thick), achieving a crosstalk of [Formula: see text] dB...
June 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28409743/pet-neck-a-multicentre-randomised-phase-iii-non-inferiority-trial-comparing-a-positron-emission-tomography-computerised-tomography-guided-watch-and-wait-policy-with-planned-neck-dissection-in-the-management-of-locally-advanced-n2-n3-nodal-metastases-in-patients
#14
Hisham Mehanna, Chris C McConkey, Joy K Rahman, Wai-Lup Wong, Alison F Smith, Chris Nutting, Andrew Gj Hartley, Peter Hall, Claire Hulme, Dharmesh K Patel, Sandra Ventorin von Zeidler, Max Robinson, Bal Sanghera, Lydia Fresco, Janet A Dunn
BACKGROUND: Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histological evidence of tumour. Consequently, a significant proportion of clinicians still practise planned ND. Fludeoxyglucose positron emission tomography (PET)-computerised tomography (CT) scanning demonstrated high negative predictive values for persistent nodal disease, providing a possible alternative paradigm to ND...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28398212/effect-of-piezoelectric-substrate-on-phonon-drag-thermopower-in-monolayer-graphene
#15
Bhargavi Kalaenahalli, Shrishail S Kubakaddi, Chris Ford
The phonon-drag thermopower is studied in monolayer graphene on a piezoelectric substrate. The phonon-drag contribution S^g_PA from the extrinsic potential of piezoelectric surface acoustic (PA) phonons of a piezoelectric substrate (GaAs) is calculated as a function of temperature T and electron concentration n_s. At very low temperature, S^g_PA is found to be much greater than S^g_DA of the intrinsic deformation potential of acoustic (DA) phonons of the graphene. There is a crossover of S^g_PA and S^g_DA at around ~ 5 K...
April 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28398046/development-of-a-13-c-nmr-chemical-shift-prediction-procedure-using-b3lyp-cc-pvdz-and-empirically-derived-systematic-error-correction-terms-a-computational-small-molecule-structure-elucidation-method
#16
Dongyue Xin, C Avery Sader, Om Chaudhary, Paul-James Jones, Klaus Wagner, Christofer S Tautermann, Zheng Yang, Carl A Busacca, Reginaldo A Saraceno, Keith R Fandrick, Nina C Gonnella, Keith Horspool, Gordon Hansen, Chris H Senanayake
An accurate and efficient procedure was developed for performing (13)C NMR chemical shift calculations employing density functional theory with the gauge invariant atomic orbitals (DFT-GIAO). Benchmarking analysis was carried out, incorporating several density functionals and basis sets commonly used for prediction of (13)C NMR chemical shifts, from which the B3LYP/cc-pVDZ level of theory was found to provide accurate results at low computational cost. Statistical analyses from a large data set of (13)C NMR chemical shifts in DMSO are presented with TMS as the calculated reference and with empirical scaling parameters obtained from a linear regression analysis...
May 2, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28378896/a-comprehensive-assessment-of-immunophenotyping-performed-in-cryopreserved-peripheral-whole-blood
#17
Chris P Verschoor, Vikas Kohli, Cynthia Balion
BACKGROUND: Monitoring the frequency and phenotype of white blood cell subsets using flow cytometry (immunophenotyping) has proven to be an incredibly powerful tool in the assessment of health. Although improved technologies have aided in the practical implementation of immunophenotyping in clinical and epidemiological studies, the transportation of blood from the site of collection to a central laboratory for analysis within a reasonable timeframe may not be feasible. Hence, the purpose of the following study was to investigate the validity of cryopreserved whole blood as a simple to prepare and cost-effective biospecimen for multi-colour immunophenotyping in a large epidemiological study-namely, The Canadian Longitudinal Study on Aging (CLSA)...
April 5, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28369824/medial-gastrocnemius-and-soleus-muscle-tendon-unit-fascicle-and-tendon-interaction-during-walking-in-children-with-cerebral-palsy
#18
Lee Barber, Chris Carty, Luca Modenese, John Walsh, Roslyn Boyd, Glen Lichtwark
AIM: This study investigates the in vivo function of the medial gastrocnemius and soleus muscle-tendon units (MTU), fascicles, and tendons during walking in children with cerebral palsy (CP) and an equinus gait pattern. METHOD: Fourteen children with CP (9 males, 5 females; mean age 10y 6mo, standard deviation [SD] 2y 11mo; GMFCS level I=8, II=6), and 10 typically developing (6 males, 4 females; mean age 10y, SD 2y 1mo) undertook full body 3D gait analysis and simultaneous B-mode ultrasound images of the medial gastrocnemius and soleus fascicles during level walking...
April 1, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28369581/guild-guidance-for-information-about-linking-data-sets%C3%A2
#19
Ruth Gilbert, Rosemary Lafferty, Gareth Hagger-Johnson, Katie Harron, Li-Chun Zhang, Peter Smith, Chris Dibben, Harvey Goldstein
Record linkage of administrative and survey data is increasingly used to generate evidence to inform policy and services. Although a powerful and efficient way of generating new information from existing data sets, errors related to data processing before, during and after linkage can bias results. However, researchers and users of linked data rarely have access to information that can be used to assess these biases or take them into account in analyses. As linked administrative data are increasingly used to provide evidence to guide policy and services, linkage error, which disproportionately affects disadvantaged groups, can undermine evidence for public health...
March 28, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28363072/radiography-in-the-field-assessing-a-lightweight-handheld-battery-powered-dentistry-unit-for-field-diagnostic-applications
#20
Katharina Seilern-Moy, Hanna Vielgrader, Hanno Gerritsmann, Chris Walzer
Radiography units are not used commonly in wildlife medicine field settings, primarily because of their weight and requirement for a power supply. In this study, a portable, battery-powered, and lightweight radiography unit, originally developed for dentistry, was assessed for its potential field applications. Radiographs of various animal species (ranging in weight from 14 g to 1,000 kg) were imaged using varying source image distance (SID) and exposure time. The quality of these images was evaluated for their resolution, image noise, and motion blur...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
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