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Chris Powers

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https://www.readbyqxmd.com/read/27934696/high-throughput-allele-specific-expression-across-250-environmental-conditions
#1
Gregory A Moyerbrailean, Allison L Richards, Daniel Kurtz, Cynthia A Kalita, Gordon O Davis, Chris T Harvey, Adnan Alazizi, Donovan Watza, Yoram Sorokin, Nancy Hauff, Xiang Zhou, Xiaoquan Wen, Roger Pique-Regi, Francesca Luca
Gene-by-environment (GxE) interactions determine common disease risk factors and biomedically relevant complex traits. However, quantifying how the environment modulates genetic effects on human quantitative phenotypes presents unique challenges. Environmental covariates are complex and difficult to measure and control at the organismal level, as found in GWAS and epidemiological studies. An alternative approach focuses on the cellular environment using in vitro treatments as a proxy for the organismal environment...
December 2016: Genome Research
https://www.readbyqxmd.com/read/27932852/evolutionary-connectionism-algorithmic-principles-underlying-the-evolution-of-biological-organisation-in-evo-devo-evo-eco-and-evolutionary-transitions
#2
Richard A Watson, Rob Mills, C L Buckley, Kostas Kouvaris, Adam Jackson, Simon T Powers, Chris Cox, Simon Tudge, Adam Davies, Loizos Kounios, Daniel Power
The mechanisms of variation, selection and inheritance, on which evolution by natural selection depends, are not fixed over evolutionary time. Current evolutionary biology is increasingly focussed on understanding how the evolution of developmental organisations modifies the distribution of phenotypic variation, the evolution of ecological relationships modifies the selective environment, and the evolution of reproductive relationships modifies the heritability of the evolutionary unit. The major transitions in evolution, in particular, involve radical changes in developmental, ecological and reproductive organisations that instantiate variation, selection and inheritance at a higher level of biological organisation...
2016: Evolutionary Biology
https://www.readbyqxmd.com/read/27930676/stochastic-simulation-service-bridging-the-gap-between-the-computational-expert-and-the-biologist
#3
Brian Drawert, Andreas Hellander, Ben Bales, Debjani Banerjee, Giovanni Bellesia, Bernie J Daigle, Geoffrey Douglas, Mengyuan Gu, Anand Gupta, Stefan Hellander, Chris Horuk, Dibyendu Nath, Aviral Takkar, Sheng Wu, Per Lötstedt, Chandra Krintz, Linda R Petzold
We present StochSS: Stochastic Simulation as a Service, an integrated development environment for modeling and simulation of both deterministic and discrete stochastic biochemical systems in up to three dimensions. An easy to use graphical user interface enables researchers to quickly develop and simulate a biological model on a desktop or laptop, which can then be expanded to incorporate increasing levels of complexity. StochSS features state-of-the-art simulation engines. As the demand for computational power increases, StochSS can seamlessly scale computing resources in the cloud...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27918669/the-within-season-distribution-of-external-training-and-racing-workload-in-professional-male-road-cyclist
#4
Alan J Metcalfe, Paolo Menaspà, Vincent Villerius, Marc Quod, Jeremiah J Peiffer, Andrew D Govus, Chris R Abbiss
PURPOSE: To describe the within-season external workloads of professional male road cyclists for optimal training prescription. METHODS: Training and racing of four international competitive professional male cyclists (age 24 ± 2 y, body mass 77.6 ± 1.5 kg) were monitored for 12 months prior to the world team time trial championships. Three within-season phases leading up to the team time trial world championships on 20(th) Sept 2015 were defined as phase one (Oct - Jan), phase two (Feb - May) and phase three (June - Sept)...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27917177/progress-on-optimizing-miscanthus-biomass-production-for-the-european-bioeconomy-results-of-the-eu-fp7-project-optimisc
#5
Iris Lewandowski, John Clifton-Brown, Luisa M Trindade, Gerard C van der Linden, Kai-Uwe Schwarz, Karl Müller-Sämann, Alexander Anisimov, C-L Chen, Oene Dolstra, Iain S Donnison, Kerrie Farrar, Simon Fonteyne, Graham Harding, Astley Hastings, Laurie M Huxley, Yasir Iqbal, Nikolay Khokhlov, Andreas Kiesel, Peter Lootens, Heike Meyer, Michal Mos, Hilde Muylle, Chris Nunn, Mensure Özgüven, Isabel Roldán-Ruiz, Heinrich Schüle, Ivan Tarakanov, Tim van der Weijde, Moritz Wagner, Qingguo Xi, Olena Kalinina
This paper describes the complete findings of the EU-funded research project OPTIMISC, which investigated methods to optimize the production and use of miscanthus biomass. Miscanthus bioenergy and bioproduct chains were investigated by trialing 15 diverse germplasm types in a range of climatic and soil environments across central Europe, Ukraine, Russia, and China. The abiotic stress tolerances of a wider panel of 100 germplasm types to drought, salinity, and low temperatures were measured in the laboratory and a field trial in Belgium...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27915432/social-learning-in-a-longitudinal-integrated-clinical-placement
#6
Chris Roberts, Michele Daly, Fabian Held, David Lyle
Recent research has demonstrated that longitudinal integrated placements (LICs) are an alternative mode of clinical education to traditional placements. Extended student engagement in community settings provide the advantages of educational continuity as well as increased service provision in underserved areas. Developing and maintaining LICs require a differing approach to student learning than that for traditional placements. There has been little theoretically informed empirical research that has offered explanations of which are the important factors that promote student learning in LICs and the relationships between those factors...
December 3, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27898810/genomic-selection-for-processing-and-end-use-quality-traits-in-the-cimmyt-spring-bread-wheat-breeding-program
#7
Sarah D Battenfield, Carlos Guzmán, R Chris Gaynor, Ravi P Singh, Roberto J Peña, Susanne Dreisigacker, Allan K Fritz, Jesse A Poland
Wheat ( L.) cultivars must possess suitable end-use quality for release and consumer acceptability. However, breeding for quality traits is often considered a secondary target relative to yield largely because of amount of seed needed and expense. Without testing and selection, many undesirable materials are advanced, expending additional resources. Here, we develop and validate whole-genome prediction models for end-use quality phenotypes in the CIMMYT bread wheat breeding program. Model accuracy was tested using forward prediction on breeding lines ( = 5520) tested in unbalanced yield trials from 2009 to 2015 at Ciudad Obregon, Sonora, Mexico...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27875167/temporal-summary-images-an-approach-to-narrative-visualization-via-interactive-annotation-generation-and-placement
#8
Chris Bryan, Kwan-Liu Ma, Jonathan Woodring
Visualization is a powerful technique for analysis and communication of complex, multidimensional, and time-varying data. However, it can be difficult to manually synthesize a coherent narrative in a chart or graph due to the quantity of visualized attributes, a variety of salient features, and the awareness required to interpret points of interest (POls). We present Temporal Summary Images (TSIs) as an approach for both exploring this data and creating stories from it. As a visualization, a TSI is composed of three common components: (1) a temporal layout, (2) comic strip-style data snapshots, and (3) textual annotations...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27874117/quantitative-analyses-of-enhanced-thermoelectric-properties-of-modulation-doped-pedot-pss-undoped-si-001-nanoscale-heterostructures
#9
Dongwook Lee, Sayed Youssef Sayed, Sangyeop Lee, Chris Adam Kuryak, Jiawei Zhou, Gang Chen, Yang Shao-Horn
Poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) has high electrical conductivity (∼10(3) S cm(-1)) but it exhibits a low Seebeck coefficient (<15 μV K(-1)), resulting in a low power factor. Mixing PEDOT:PSS with nanostructured semiconductors can enhance the Seebeck coefficient and achieve an improved thermoelectric power factor. However, underlying mechanisms for those composite thermoelectric systems are scarcely understood so far. In this study, quantitative analyses on the electrical conductivity and Seebeck coefficient for the heterostructures of nanometer-thick PEDOT:PSS on single-crystal Si (001) on sapphire (SOS) are reported...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27870019/silica-uptake-and-release-in-live-and-decaying-biomass-in-a-northern-hardwood-forest
#10
Wim Clymans, Daniel J Conley, John J Battles, Patrick J Frings, Mary Margaret Koppers, Gene E Likens, Chris E Johnson
In terrestrial ecosystems, a large portion (20-80%) of the dissolved Si (DSi) in soil solution has passed through vegetation. While the importance of this "terrestrial Si filter" is generally accepted, few data exist on the pools and fluxes of Si in forest vegetation and the rate of release of Si from decomposing plant tissues. We quantified the pools and fluxes of Si through vegetation and coarse woody debris (CWD) in a northern hardwood forest ecosystem (Watershed 6, W6) at the Hubbard Brook Experimental Forest (HBEF) in New Hampshire, USA...
November 2016: Ecology
https://www.readbyqxmd.com/read/27863249/lineage-specific-genome-architecture-links-enhancers-and-non-coding-disease-variants-to-target-gene-promoters
#11
Biola M Javierre, Oliver S Burren, Steven P Wilder, Roman Kreuzhuber, Steven M Hill, Sven Sewitz, Jonathan Cairns, Steven W Wingett, Csilla Várnai, Michiel J Thiecke, Frances Burden, Samantha Farrow, Antony J Cutler, Karola Rehnström, Kate Downes, Luigi Grassi, Myrto Kostadima, Paula Freire-Pritchett, Fan Wang, Hendrik G Stunnenberg, John A Todd, Daniel R Zerbino, Oliver Stegle, Willem H Ouwehand, Mattia Frontini, Chris Wallace, Mikhail Spivakov, Peter Fraser
Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major missing link in understanding genome control. Here, we use promoter capture Hi-C to identify interacting regions of 31,253 promoters in 17 human primary hematopoietic cell types. We show that promoter interactions are highly cell type specific and enriched for links between active promoters and epigenetically marked enhancers...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27828877/elevated-red-cell-distribution-width-rdw-identifies-elevated-cardiovascular-disease-risk-in-patients-with-hiv-infection
#12
Sadeer G Al-Kindi, Chang H Kim, Stephen R Morris, Michael L Freeman, Nicholas T Funderburg, Benigno Rodriguez, Grace A McComsey, Jarrod E Dalton, Daniel I Simon, Michael M Lederman, Chris T Longenecker, David A Zidar
Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with Human Immunodeficiency Virus (HIV) infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (>14.5%) is independently associated with increased risk of coronary artery disease (odds ratio (OR) 1.39 [1.25-1.55]), peripheral vascular disease (OR 1.41 [1.29-1.53]), myocardial infarction (1...
November 4, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27828071/overview-of-advanced-ligo-adaptive-optics
#13
Aidan F Brooks, Benjamin Abbott, Muzammil A Arain, Giacomo Ciani, Ayodele Cole, Greg Grabeel, Eric Gustafson, Chris Guido, Matthew Heintze, Alastair Heptonstall, Mindy Jacobson, Won Kim, Eleanor King, Alexander Lynch, Stephen O'Connor, David Ottaway, Ken Mailand, Guido Mueller, Jesper Munch, Virginio Sannibale, Zhenhua Shao, Michael Smith, Peter Veitch, Thomas Vo, Cheryl Vorvick, Phil Willems
This is an overview of the adaptive optics used in Advanced LIGO (aLIGO), known as the thermal compensation system (TCS). The TCS was designed to minimize thermally induced spatial distortions in the interferometer optical modes and to provide some correction for static curvature errors in the core optics of aLIGO. The TCS is comprised of ring heater actuators, spatially tunable CO<sub>2</sub> laser projectors, and Hartmann wavefront sensors. The system meets the requirements of correcting for nominal distortion in aLIGO to a maximum residual error of 5...
October 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27825551/repeated-sprint-ability-but-not-neuromuscular-fatigue-is-dependent-on-short-versus-long-duration-recovery-time-between-sprints-in-healthy-males
#14
Michael R Monks, Chris T Compton, Joseph D Yetman, Kevin E Power, Duane C Button
OBJECTIVES: During maximal intensity leg cycling sprints, previous research has shown that central and peripheral fatigue development occurs with various (<30s) short-duration recovery periods between sprints. The aim of the current study was to compare the development of neuromuscular fatigue during maximal intensity lower-body sprints interspersed with short and longer duration recovery periods. DESIGN: Crossover study. METHODS: Ten participants completed 10, 10s sprints interspersed with either 30 or 180s of recovery...
October 27, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27818113/factors-in-the-success-of-new-contact-lens-wearers
#15
Anna Sulley, Graeme Young, Chris Hunt
PURPOSE: To determine the first-year retention rate for patients fitted with contact lenses (CLs) and identify factors associated with retention and dropout. METHODS: This multi-site study was a retrospective chart review of the status of neophyte CL wearers fitted in representative UK eye care practices. RESULTS: Consecutive records for 524 patients at 29 sites were reviewed. Mean age at dispensing was 34 years (range 8-79), 68% were under 45 years and 61% female...
November 3, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27806011/do-fencers-require-a-weapon-specific-approach-to-strength-and-conditioning-training
#16
Anthony N Turner, Chris Bishop, Jon Cree, Michael Edwards, Shyam Chavda, Paul Read, David Kirby
There are three types of weapon used in Olympic fencing: the épée, foil, and sabre. The aim of this study was to determine if fencers exhibited different physical characteristics across weapons. Seventy-nine male (n = 46) and female (n = 33) national standard fencers took part in this study. Fencers from each weapon (male and female), i.e., épée (n = 19 and 10), foil (n = 22 and 14), and sabre (n = 13 and 10) were (mean ± SD) 15.9 ± 0.7 years of age, 178.5 ± 7.9 cm tall, 67.4 ± 12.2 kg in mass and had 6...
October 26, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27803392/selecting-patients-for-intra-arterial-therapy-in-the-context-of-a-clinical-trial-for-neuroprotection
#17
Patrick Lyden, Sara Weymer, Chris Coffey, Merit Cudkowicz, Samantha Berg, Sarah O'Brien, Marc Fisher, E Clarke Haley, Pooja Khatri, Jeff Saver, Steven Levine, Howard Levy, Marilyn Rymer, Lawrence Wechsler, Ashutosh Jadhav, Elizabeth McNeil, Salina Waddy, Kent Pryor
BACKGROUND AND PURPOSE: The advent of intra-arterial neurothrombectomy (IAT) for acute ischemic stroke opens a potentially transformative opportunity to improve neuroprotection studies. Combining a putative neuroprotectant with recanalization could produce more powerful trials but could introduce heterogeneity and adverse event possibilities. We sought to demonstrate feasibility of IAT in neuroprotectant trials by defining IAT selection criteria for an ongoing neuroprotectant clinical trial...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27800062/multiparametric-magnetic-resonance-imaging-for-pre-treatment-local-staging-of-prostate-cancer-a-cancer-care-ontario-clinical-practice-guideline
#18
Jennifer Salerno, Antonio Finelli, Chris Morash, Scott C Morgan, Nicholas Power, Nichola Schieda, Masoom A Haider
INTRODUCTION: The utility of T2-weighted magnetic resonance imaging (MRI) in the local staging of prostate cancer is controversial. Due to the success of multiparametric MRI in cancer localization, there is renewed interested in MRI (± functional sequences) for local staging. Guidance on pre-treatment local staging of prostate cancer by MRI was developed using systematic review methodology and expert consultation. METHODS: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and other databases were searched to identify studies comparing: (1) MRI staging vs...
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27799064/mipep-recessive-variants-cause-a-syndrome-of-left-ventricular-non-compaction-hypotonia-and-infantile-death
#19
Mohammad K Eldomery, Zeynep C Akdemir, F-Nora Vögtle, Wu-Lin Charng, Patrycja Mulica, Jill A Rosenfeld, Tomasz Gambin, Shen Gu, Lindsay C Burrage, Aisha Al Shamsi, Samantha Penney, Shalini N Jhangiani, Holly H Zimmerman, Donna M Muzny, Xia Wang, Jia Tang, Ravi Medikonda, Prasanna V Ramachandran, Lee-Jun Wong, Eric Boerwinkle, Richard A Gibbs, Christine M Eng, Seema R Lalani, Jozef Hertecant, Richard J Rodenburg, Omar A Abdul-Rahman, Yaping Yang, Fan Xia, Meng C Wang, James R Lupski, Chris Meisinger, V Reid Sutton
BACKGROUND: Mitochondrial presequence proteases perform fundamental functions as they process about 70 % of all mitochondrial preproteins that are encoded in the nucleus and imported posttranslationally. The mitochondrial intermediate presequence protease MIP/Oct1, which carries out precursor processing, has not yet been established to have a role in human disease. METHODS: Whole exome sequencing was performed on four unrelated probands with left ventricular non-compaction (LVNC), developmental delay (DD), seizures, and severe hypotonia...
November 1, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27798627/genome-wide-analysis-identifies-12-loci-influencing-human-reproductive-behavior
#20
Nicola Barban, Rick Jansen, Ronald de Vlaming, Ahmad Vaez, Jornt J Mandemakers, Felix C Tropf, Xia Shen, James F Wilson, Daniel I Chasman, Ilja M Nolte, Vinicius Tragante, Sander W van der Laan, John R B Perry, Augustine Kong, Tarunveer S Ahluwalia, Eva Albrecht, Laura Yerges-Armstrong, Gil Atzmon, Kirsi Auro, Kristin Ayers, Andrew Bakshi, Danny Ben-Avraham, Klaus Berger, Aviv Bergman, Lars Bertram, Lawrence F Bielak, Gyda Bjornsdottir, Marc Jan Bonder, Linda Broer, Minh Bui, Caterina Barbieri, Alana Cavadino, Jorge E Chavarro, Constance Turman, Maria Pina Concas, Heather J Cordell, Gail Davies, Peter Eibich, Nicholas Eriksson, Tõnu Esko, Joel Eriksson, Fahimeh Falahi, Janine F Felix, Mark Alan Fontana, Lude Franke, Ilaria Gandin, Audrey J Gaskins, Christian Gieger, Erica P Gunderson, Xiuqing Guo, Caroline Hayward, Chunyan He, Edith Hofer, Hongyan Huang, Peter K Joshi, Stavroula Kanoni, Robert Karlsson, Stefan Kiechl, Annette Kifley, Alexander Kluttig, Peter Kraft, Vasiliki Lagou, Cecile Lecoeur, Jari Lahti, Ruifang Li-Gao, Penelope A Lind, Tian Liu, Enes Makalic, Crysovalanto Mamasoula, Lindsay Matteson, Hamdi Mbarek, Patrick F McArdle, George McMahon, S Fleur W Meddens, Evelin Mihailov, Mike Miller, Stacey A Missmer, Claire Monnereau, Peter J van der Most, Ronny Myhre, Mike A Nalls, Teresa Nutile, Ioanna Panagiota Kalafati, Eleonora Porcu, Inga Prokopenko, Kumar B Rajan, Janet Rich-Edwards, Cornelius A Rietveld, Antonietta Robino, Lynda M Rose, Rico Rueedi, Kathleen A Ryan, Yasaman Saba, Daniel Schmidt, Jennifer A Smith, Lisette Stolk, Elizabeth Streeten, Anke Tönjes, Gudmar Thorleifsson, Sheila Ulivi, Juho Wedenoja, Juergen Wellmann, Peter Willeit, Jie Yao, Loic Yengo, Jing Hua Zhao, Wei Zhao, Daria V Zhernakova, Najaf Amin, Howard Andrews, Beverley Balkau, Nir Barzilai, Sven Bergmann, Ginevra Biino, Hans Bisgaard, Klaus Bønnelykke, Dorret I Boomsma, Julie E Buring, Harry Campbell, Stefania Cappellani, Marina Ciullo, Simon R Cox, Francesco Cucca, Daniela Toniolo, George Davey-Smith, Ian J Deary, George Dedoussis, Panos Deloukas, Cornelia M van Duijn, Eco J C de Geus, Johan G Eriksson, Denis A Evans, Jessica D Faul, Cinzia Felicita Sala, Philippe Froguel, Paolo Gasparini, Giorgia Girotto, Hans-Jörgen Grabe, Karin Halina Greiser, Patrick J F Groenen, Hugoline G de Haan, Johannes Haerting, Tamara B Harris, Andrew C Heath, Kauko Heikkilä, Albert Hofman, Georg Homuth, Elizabeth G Holliday, John Hopper, Elina Hyppönen, Bo Jacobsson, Vincent W V Jaddoe, Magnus Johannesson, Astanand Jugessur, Mika Kähönen, Eero Kajantie, Sharon L R Kardia, Bernard Keavney, Ivana Kolcic, Päivikki Koponen, Peter Kovacs, Florian Kronenberg, Zoltan Kutalik, Martina La Bianca, Genevieve Lachance, William G Iacono, Sandra Lai, Terho Lehtimäki, David C Liewald, Cecilia M Lindgren, Yongmei Liu, Robert Luben, Michael Lucht, Riitta Luoto, Per Magnus, Patrik K E Magnusson, Nicholas G Martin, Matt McGue, Ruth McQuillan, Sarah E Medland, Christa Meisinger, Dan Mellström, Andres Metspalu, Michela Traglia, Lili Milani, Paul Mitchell, Grant W Montgomery, Dennis Mook-Kanamori, Renée de Mutsert, Ellen A Nohr, Claes Ohlsson, Jørn Olsen, Ken K Ong, Lavinia Paternoster, Alison Pattie, Brenda W J H Penninx, Markus Perola, Patricia A Peyser, Mario Pirastu, Ozren Polasek, Chris Power, Jaakko Kaprio, Leslie J Raffel, Katri Räikkönen, Olli Raitakari, Paul M Ridker, Susan M Ring, Kathryn Roll, Igor Rudan, Daniela Ruggiero, Dan Rujescu, Veikko Salomaa, David Schlessinger, Helena Schmidt, Reinhold Schmidt, Nicole Schupf, Johannes Smit, Rossella Sorice, Tim D Spector, John M Starr, Doris Stöckl, Konstantin Strauch, Michael Stumvoll, Morris A Swertz, Unnur Thorsteinsdottir, A Roy Thurik, Nicholas J Timpson, Joyce Y Tung, André G Uitterlinden, Simona Vaccargiu, Jorma Viikari, Veronique Vitart, Henry Völzke, Peter Vollenweider, Dragana Vuckovic, Johannes Waage, Gert G Wagner, Jie Jin Wang, Nicholas J Wareham, David R Weir, Gonneke Willemsen, Johann Willeit, Alan F Wright, Krina T Zondervan, Kari Stefansson, Robert F Krueger, James J Lee, Daniel J Benjamin, David Cesarini, Philipp D Koellinger, Marcel den Hoed, Harold Snieder, Melinda C Mills
The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort...
October 31, 2016: Nature Genetics
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