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Chris Powers

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https://www.readbyqxmd.com/read/28718977/effect-of-simulated-gastrointestinal-digestion-and-fermentation-on-polyphenolic-content-and-bioactivity-of-brown-seaweed-phlorotannin-rich-extracts
#1
Giulia Corona, Maria Magdalena Coman, Yuxuan Guo, Sarah Hotchkiss, Chris Gill, Parveen Yaqoob, Jeremy P E Spencer, Ian Rowland
SCOPE: Unlike other classes of polyphenols, there is a lack of knowledge regarding brown seaweed phlorotannins and their bioactivity. We investigated the impact of in vitro gastrointestinal digestion and colonic fermentation on the bioactivity of a seaweed phlorotannin extract from Ascophyllum nodosum and its high molecular weight (HMW) and low molecular weight (LMW) fractions. METHODS AND RESULTS: The highest phlorotannin and total polyphenol (TP) concentration was observed in the HMW fraction...
July 18, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28701505/remotely-sensed-wind-speed-predicts-soaring-behaviour-in-a-wide-ranging-pelagic-seabird
#2
Rory Gibb, Akiko Shoji, Annette L Fayet, Chris M Perrins, Tim Guilford, Robin Freeman
Global wind patterns affect flight strategies in many birds, including pelagic seabirds, many of which use wind-powered soaring to reduce energy costs during at-sea foraging trips and migration. Such long-distance movement patterns are underpinned by local interactions between wind conditions and flight behaviour, but these fine-scale relationships are far less well understood. Here we show that remotely sensed ocean wind speed and direction are highly significant predictors of soaring behaviour in a migratory pelagic seabird, the Manx shearwater (Puffinus puffinus)...
July 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28689855/planyourlifespan-org-an-intervention-to-help-seniors-make-choices-for-their-fourth-quarter-of-life-results-from-the-randomized-clinical-trial
#3
Lee A Lindquist, Vanessa Ramirez-Zohfeld, Priya D Sunkara, Chris Forcucci, Dianne S Campbell, Phyllis Mitzen, Jody D Ciolino, Dyanna Gregory, Gayle Kricke, Kenzie A Cameron
OBJECTIVE: Few older adults contemplate their home support and health needs that may be required for aging-in-place. We sought to assess the efficacy of PlanYourLifespan.org (PYL), in influencing seniors' planning behaviors, perception of the importance of planning, and confidence accessing services. METHOD: Randomized controlled trial, of adults, age ≥65 years in urban, suburban, rural areas of Texas, Illinois, Indiana. RESULTS: Among 385 participants, mean age was 71...
June 27, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28686555/heat-related-mortality-in-japan-after-the-2011-fukushima-disaster-an-analysis-of-potential-influence-of-reduced-electricity-consumption
#4
Yoonhee Kim, Antonio Gasparrini, Masahiro Hashizume, Yasushi Honda, Chris Fook Sheng Ng, Ben Armstrong
BACKGROUND: In March 2011, the Great East Japan Earthquake devastated several power stations and caused severe electricity shortages. This accident was followed by the implementation of policies to reduce summer electricity consumption in the affected areas, for example, by limiting air-conditioning (AC) use. This provided a natural experimental scenario to investigate if these policies were associated with an increase in heat-related mortality. OBJECTIVES: We examined whether the reduced electricity consumption in warm season modified heat-related mortality from 2008 to 2012...
July 6, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28671471/solution-processed-carbon-nanotube-true-random-number-generator
#5
William A Gaviria Rojas, Julian J McMorrow, Michael L Geier, Qianying Tang, Chris H Kim, Tobin J Marks, Mark C Hersam
With the growing adoption of interconnected electronic devices in consumer and industrial applications, there is an increasing demand for robust security protocols when transmitting and receiving sensitive data. Toward this end, hardware true random number generators (TRNGs), commonly used to create encryption keys, offer significant advantages over software pseudorandom number generators. However, the vast network of devices and sensors envisioned for the "Internet of Things" will require small, low-cost, and mechanically flexible TRNGs with low computational complexity...
July 7, 2017: Nano Letters
https://www.readbyqxmd.com/read/28658073/monitoring-changes-in-power-speed-agility-and-endurance-in-elite-cricketers-during-the-off-season
#6
Chris Bishop, Ross Herridge, Anthony Turner
The purpose of this study was to monitor changes in power, speed, agility and endurance in elite cricketers during the 20-week off-season period. Fourteen elite male cricketers (age 26.2 ± 5.3years; height 180.8 ± 8.5cm; mass 83.5 ± 6.7kg) conducted a physical testing battery in week 1 and week 18 of the off-season period. The testing included a yoyo intermittent recovery test (yoyo IRT), bilateral and unilateral countermovement jumps (CMJ), squat jump (SJ), broad jump (BJ), drop jump (to calculate reactive strength index - [RSI]), pro agility and 5, 10, 20m sprint tests...
June 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28656157/opportunities-lost-and-gained-changes-in-progenitor-competence-during-nervous-system-development
#7
REVIEW
Dylan R Farnsworth, Chris Q Doe
During development of the central nervous system, a small pool of stem cells and progenitors generate the vast neural diversity required for neural circuit formation and behavior. Neural stem and progenitor cells often generate different progeny in response to the same signaling cue (e.g. Notch or Hedgehog), including no response at all. How does stem cell competence to respond to signaling cues change over time? Recently, epigenetics particularly chromatin remodeling - has emerged as a powerful mechanism to control stem cell competence...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28650739/the-effect-of-high-intensity-exercise-and-anticipation-on-trunk-and-lower-limb-biomechanics-during-a-crossover-cutting-manoeuvre
#8
Enda F Whyte, Chris Richter, Siobhan O'connor, Kieran A Moran
We investigated the effects of high intensity, intermittent exercise (HIIP) and anticipation on trunk, pelvic and lower limb biomechanics during a crossover cutting manoeuvre. Twenty-eight male, varsity athletes performed crossover cutting manoeuvres in anticipated and unanticipated conditions pre- and post-HIIP. Kinematic and kinetic variables were captured using a motion analysis system. Statistical parametric mapping (repeated-measures ANOVA) was used to identify differences in biomechanical patterns. Results demonstrated that both unanticipation and fatigue (HIIP) altered the biomechanics of the crossover cutting manoeuvre, whereas no interactions effects were observed...
June 26, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28644195/considerations-for-selecting-field-based-strength-and-power-fitness-tests-to-measure-asymmetries
#9
Chris Bishop, Anthony Turner, Shyam Chavda, Paul Jarvis, Paul Read
The prevalence of lower limb asymmetries has been reported in numerous studies; however, methodological differences exist in the way they can be detected. Strength and jumping-based tasks have been most commonly used to examine these differences across both athlete and non-athlete populations. The aim of this review was to critically analyze the utility of strength and jumping tests that are frequently used to measure asymmetry. Reliability, validity, and considerations for assessment are examined to enhance test accuracy and effectiveness in the quantification of asymmetries during strength and jumping-based tasks...
June 19, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28643794/enrichment-of-low-frequency-functional-variants-revealed-by-whole-genome-sequencing-of-multiple-isolated-european-populations
#10
Yali Xue, Massimo Mezzavilla, Marc Haber, Shane McCarthy, Yuan Chen, Vagheesh Narasimhan, Arthur Gilly, Qasim Ayub, Vincenza Colonna, Lorraine Southam, Christopher Finan, Andrea Massaia, Himanshu Chheda, Priit Palta, Graham Ritchie, Jennifer Asimit, George Dedoussis, Paolo Gasparini, Aarno Palotie, Samuli Ripatti, Nicole Soranzo, Daniela Toniolo, James F Wilson, Richard Durbin, Chris Tyler-Smith, Eleftheria Zeggini
The genetic features of isolated populations can boost power in complex-trait association studies, and an in-depth understanding of how their genetic variation has been shaped by their demographic history can help leverage these advantageous characteristics. Here, we perform a comprehensive investigation using 3,059 newly generated low-depth whole-genome sequences from eight European isolates and two matched general populations, together with published data from the 1000 Genomes Project and UK10K. Sequencing data give deeper and richer insights into population demography and genetic characteristics than genotype-chip data, distinguishing related populations more effectively and allowing their functional variants to be studied more fully...
June 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28641265/a-new-method-for-neural-spike-alignment-the-centroid-filter
#11
Benjamin Metcalfe, Chris Clarke, Nick Donaldson, John Taylor
Recordings made directly from the nervous system are a key tool in experimental electrophysiology and the development of bioelectronic medicines. Analysis of these recordings involves the identification of signals from individual neurons, a process known as spike sorting. A critical and limiting feature of spike sorting is the need to align individual spikes in time. However, electrophysiological recordings are made in extremely noisy environments that seriously limit the performance of the spike-alignment process...
June 16, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28637423/the-relation-between-dna-methylation-patterns-and-serum-cytokine-levels-in-community-dwelling-adults-a-preliminary-study
#12
Chris P Verschoor, Lisa M McEwen, Vikas Kohli, Christina Wolfson, Dawn Me Bowdish, Parminder Raina, Michael S Kobor, Cynthia Balion
BACKGROUND: The levels of circulating cytokines fluctuate with age, acute illness, and chronic disease, and are predictive of mortality; this is also true for patterns of DNA (CpG) methylation. Given that immune cells are particularly sensitive to changes in the concentration of cytokines in their microenvironment, we hypothesized that serum levels of TNF, IL-6, IL-8 and IL-10 would correlate with genome-wide alterations in the DNA methylation levels of blood leukocytes. To test this, we evaluated community-dwelling adults (n = 14; 48-78 years old) recruited to a pilot study for the Canadian Longitudinal Study on Aging (CLSA), examining DNA methylation patterns in peripheral blood mononuclear cells using the Illumina HumanMethylation 450 K BeadChip...
June 21, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28633477/loop-diuretics-for-chronic-heart-failure-a-foe-in-disguise-of-a-friend
#13
Chris J Kapelios, Konstantinos Malliaras, Elisabeth Kaldara, Stella Vakrou, John N Nanas
Loop diuretics are recommended for relieving symptoms and signs of congestion in patients with chronic heart failure and are administered to more than 80% of them. However, several of their effects have not systematically been studied. Numerous cohort and four interventional studies have addressed the effect of diuretics on renal function; apart from one prospective study, which showed that diuretics withdrawal is accompanied by increase in some markers of early-detected renal injury, all others converge to the conclusion that diuretics receipt, especially in high doses is associated with increased rates of renal dysfunction...
June 19, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28629390/results-of-the-first-interim-analysis-of-the-rapper-ii-trial-in-patients-with-spinal-cord-injury-ambulation-and-functional-exercise-programs-in-the-rex-powered-walking-aid
#14
Nick Birch, Jon Graham, Tom Priestley, Chris Heywood, Mohamed Sakel, Angela Gall, Andrew Nunn, Nada Signal
BACKGROUND: The RAPPER II study investigates the feasibility, safety and acceptability of using the REX self-stabilising robotic exoskeleton in people with spinal cord injury (SCI) who are obligatory wheelchair users. Feasibility is assessed by the completion of transfer into the REX device, competency in achieving autonomous control and completion of upper body exercise in an upright position in the REX device. Safety is measured by the occurrence of serious adverse events. Device acceptability is assessed with a user questionnaire...
June 19, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28612635/wearable-sensors-can-they-benefit-patients-with-chronic-kidney-disease
#15
Fokko Pieter Wieringa, Natascha Juliana Hendrika Broers, Jeroen Peter Kooman, Frank M Van Der Sande, Chris Van Hoof
This article ponders upon wearable medical measurement devices in relation to Chronic Kidney Disease (CKD) and its' associated comorbidities - and whether these might benefit CKD-patients. We aimed to map the intersection(s) of nephrology and wearable sensor technology to help technologists understand medical aspects, and clinicians to understand technological possibilities that are available (or soon will become so). Areas covered: A structured literature search on main comorbidities and complications CKD patients suffer from, was used to steer mini-reviews on wearable sensor technologies clustered around 3 themes being: Cardiovascular-related, diabetes-related and physical fitness/frailty...
June 28, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28601380/reprint-of-trouble-on-takeoff-crude-oil-on-feathers-reduces-escape-performance-of-shorebirds
#16
Ivan Maggini, Lisa V Kennedy, Kyle H Elliott, Karen M Dean, Robert MacCurdy, Alexander Macmillan, Chris A Pritsos, Christopher G Guglielmo
The ability to takeoff quickly and accelerate away from predators is crucial to bird survival. Crude oil can disrupt the fine structure and function of feathers, and here we tested for the first time how small amounts of oil on the trailing edges of the wings and tail of Western sandpipers (Calidris mauri) affected takeoff flight performance. In oiled birds, the distance travelled during the first 0.4s after takeoff was reduced by 29%, and takeoff angle was decreased by 10° compared to unoiled birds. Three-axis accelerometry indicated that oiled sandpipers produced less mechanical power output per wingbeat during the initial phase of flight...
June 7, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28595879/predictors-of-successful-hybrid-approach-chronic-total-coronary-artery-occlusion%C3%A2-stenting-an-improved-model-with-novel-correlates
#17
Stephen G Ellis, M Nicholas Burke, M Bilal Murad, John J Graham, Ramy Badawi, Catelin Toma, Henry Meltser, Ravi Nair, Chris Buller, Patrick L Whitlow
OBJECTIVES: The aim of this study was to develop a hybrid approach-specific model to predict chronic total coronary artery occlusion (CTO) percutaneous coronary intervention success, useful for experienced but not ultra-high-volume operators. BACKGROUND: CTO percutaneous coronary intervention success rates vary widely and have improved with the "hybrid approach," but current predictive models for success have major limitations. METHODS: Data were obtained from consecutively attempted patients from 7 clinical sites (9 operators, mean annual CTO volume 61 ± 17 cases)...
June 12, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28592196/the-use-of-self-directed-relapse-prevention-booklets-to-assist-in-maintaining-abstinence-after-a-6-week-group-smoking-cessation-treatment-program-a-randomized-controlled-trial
#18
Susan Veldheer, Shari Hrabovsky, Jessica Yingst, Chris Sciamanna, Arthur Berg, Jonathan Foulds
BACKGROUND: Identifying effective relapse prevention interventions is a vital step to help smokers maintain abstinence for the long term. AIMS: The purpose of this study is to determine if providing recently quit smokers with self-directed relapse prevention booklets is effective at maintaining abstinence after intensive group smoking cessation treatment. METHOD: Two hundred and twenty-five participants were randomized to receive Forever Free (FF) relapse prevention booklets or a control booklet (Surgeon General's report, SG) at the end of a 6-week group treatment program...
June 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28575022/investigating-the-effect-of-forestry-on-leaf-litter-arthropods-algonquin-park-ontario-canada
#19
M Alex Smith, Amanda Boyd, Amelia Chan, Simonne Clout, Paulson des Brisay, Sarah Dolson, Thanushi Eagalle, Sean Espinola, Aaron Fairweather, Sydney Frank, Christopher Fruetel, Cristina Garrido Cortes, James Hall, Chris Ho, Eryk Matczak, Sandra McCubbin, Megan McPhee, Kate A Pare, Kelsie Paris, Ellen Richard, Morgan Roblin, Cassandra Russell, Ryan Snyder, Carolyn Trombley, Tyler Schmitt, Caitlin Vandermeer, Connor Warne, Natasha Welch, Chelsie Xavier-Blower
Arthropods are the most diverse taxonomic group of terrestrial eukaryotes and are sensitive to physical alterations in their environment such as those caused by forestry. With their enormous diversity and physical omnipresence, arthropods could be powerful indicators of the effects of disturbance following forestry. When arthropods have been used to measure the effects of disturbance, the total diversity of some groups is often found to increase following forestry. However, these findings are frequently derived using a coarse taxonomic grain (family or order) to accommodate for various taxonomic impediments (including cryptic diversity and poorly resourced taxonomists)...
2017: PloS One
https://www.readbyqxmd.com/read/28552196/whole-genome-sequencing-coupled-to-imputation-discovers-genetic-signals-for-anthropometric-traits
#20
Ioanna Tachmazidou, Dániel Süveges, Josine L Min, Graham R S Ritchie, Julia Steinberg, Klaudia Walter, Valentina Iotchkova, Jeremy Schwartzentruber, Jie Huang, Yasin Memari, Shane McCarthy, Andrew A Crawford, Cristina Bombieri, Massimiliano Cocca, Aliki-Eleni Farmaki, Tom R Gaunt, Pekka Jousilahti, Marjolein N Kooijman, Benjamin Lehne, Giovanni Malerba, Satu Männistö, Angela Matchan, Carolina Medina-Gomez, Sarah J Metrustry, Abhishek Nag, Ioanna Ntalla, Lavinia Paternoster, Nigel W Rayner, Cinzia Sala, William R Scott, Hashem A Shihab, Lorraine Southam, Beate St Pourcain, Michela Traglia, Katerina Trajanoska, Gialuigi Zaza, Weihua Zhang, María S Artigas, Narinder Bansal, Marianne Benn, Zhongsheng Chen, Petr Danecek, Wei-Yu Lin, Adam Locke, Jian'an Luan, Alisa K Manning, Antonella Mulas, Carlo Sidore, Anne Tybjaerg-Hansen, Anette Varbo, Magdalena Zoledziewska, Chris Finan, Konstantinos Hatzikotoulas, Audrey E Hendricks, John P Kemp, Alireza Moayyeri, Kalliope Panoutsopoulou, Michal Szpak, Scott G Wilson, Michael Boehnke, Francesco Cucca, Emanuele Di Angelantonio, Claudia Langenberg, Cecilia Lindgren, Mark I McCarthy, Andrew P Morris, Børge G Nordestgaard, Robert A Scott, Martin D Tobin, Nicholas J Wareham, Paul Burton, John C Chambers, George Davey Smith, George Dedoussis, Janine F Felix, Oscar H Franco, Giovanni Gambaro, Paolo Gasparini, Christopher J Hammond, Albert Hofman, Vincent W V Jaddoe, Marcus Kleber, Jaspal S Kooner, Markus Perola, Caroline Relton, Susan M Ring, Fernando Rivadeneira, Veikko Salomaa, Timothy D Spector, Oliver Stegle, Daniela Toniolo, André G Uitterlinden, Inês Barroso, Celia M T Greenwood, John R B Perry, Brian R Walker, Adam S Butterworth, Yali Xue, Richard Durbin, Kerrin S Small, Nicole Soranzo, Nicholas J Timpson, Eleftheria Zeggini
Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole-genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of 12 anthropometric traits associated with height, body mass, and fat distribution in up to 267,616 individuals. We report 106 genome-wide significant signals that have not been previously identified, including 9 low-frequency variants pointing to functional candidates...
June 1, 2017: American Journal of Human Genetics
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