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Chris Powers

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https://www.readbyqxmd.com/read/28230154/compiler-aided-systematic-construction-of-large-scale-dna-strand-displacement-circuits-using-unpurified-components
#1
Anupama J Thubagere, Chris Thachuk, Joseph Berleant, Robert F Johnson, Diana A Ardelean, Kevin M Cherry, Lulu Qian
Biochemical circuits made of rationally designed DNA molecules are proofs of concept for embedding control within complex molecular environments. They hold promise for transforming the current technologies in chemistry, biology, medicine and material science by introducing programmable and responsive behaviour to diverse molecular systems. As the transformative power of a technology depends on its accessibility, two main challenges are an automated design process and simple experimental procedures. Here we demonstrate the use of circuit design software, combined with the use of unpurified strands and simplified experimental procedures, for creating a complex DNA strand displacement circuit that consists of 78 distinct species...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28227054/covariance-based-outlier-detection-with-feature-selection
#2
Chris E Zwilling, Michelle Y Wang, Chris E Zwilling, Michelle Y Wang, Chris E Zwilling, Michelle Y Wang
The present covariance based outlier detection algorithm selects from a candidate set of feature vectors that are best at identifying outliers. Features extracted from biomedical and health informatics data can be more informative in disease assessment and there are no restrictions on the nature and number of features that can be tested. But an important challenge for an algorithm operating on a set of features is for it to winnow the effective features from the ineffective ones. The powerful algorithm described in this paper leverages covariance information from the time series data to identify features with the highest sensitivity for outlier identification...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223996/untargeted-metabotyping-lolium-perenne-reveals-population-level-variation-in-plant-flavonoids-and-alkaloids
#3
Mingshu Cao, Karl Fraser, Chris Jones, Alan Stewart, Thomas Lyons, Marty Faville, Brent Barrett
Metabolomics provides a powerful platform to characterize plants at the biochemical level, allowing a search for underlying genes and associations with higher level complex traits such as yield and nutritional value. Efficient and reliable methods to characterize metabolic variation in economically important species are considered of high value to the evaluation and prioritization of germplasm and breeding lines. In this investigation, a large-scale metabolomic survey was performed on a collection of diverse perennial ryegrass (Lolium perenne L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28222264/graphene-ink-laminate-structures-on-polyvinylidene-difluoride-pvdf-for-pyroelectric-thermal-energy-harvesting-and-waste-heat-recovery
#4
Daniel Zabek, Kris Seunarine, Chris Spacie, Chris R Bowen
Thermal energy can be effectively converted into electricity using pyroelectrics, which act as small scale power generator and energy harvesters providing nW to mW of electrical power. In this paper, a novel pyroelectric harvester based on free standing polyvinilidene difluoride (PVDF) was manufactured that exploits the high thermal radiation absorbance of a screen printed graphene-ink electrode structure to facilitate the conversion of the available thermal radiation energy into electrical energy. The interconnected graphene nanoplatelets (GNPs) enable high thermal radiation absorbance and high electrical conductivity along with the ease of deposition using a screen print technique...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28218928/innovative-mental-health-clinical-placement-developing-nurses-relationship-skills
#5
Dana Perlman, Ellie Taylor, Lorna Moxham, Chris Patterson, Renee Brighton, Tim Heffernan, Susan Sumskis
Engagement in clinical placements is mandatory for all pre-registration nursing programs. Although clinical placements can be valuable, recent literature illustrates that placements within a mental health setting can vary in their educational development. The aim of the current study was to examine the potential learning benefit of 20 pre-registration nursing students in an innovative, university-accredited mental health clinical placement called Recovery Camp. Recovery Camp is a 5-day immersive clinical placement, grounded in therapeutic recreation, which involves all participants engaging in a variety of activities focused on enhancing personal recovery...
February 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28196836/label-free-dynamic-mass-redistribution-reveals-low-density-pro-survival-%C3%AE-1b-adrenergic-receptors-in-human-sw480-colon-carcinoma-cells
#6
Dorathy-Ann Harris, Ji-Min Park, Kyung Soon-Lee, Cong Xu, Nephi Stella, Chris Hague
Small molecules that target the adrenergic family of G protein-coupled receptors (GPCRs) show promising therapeutic efficacy for the treatment of various cancers. Herein, we report that human colon cancer cell line SW480 expresses low-density functional α1B-adrenergic receptors (ARs) as revealed by label-free dynamic mass redistribution (DMR) signaling technology and confirmed by quantitative reverse-transcriptase polymerase chain reaction analysis. Remarkably, while endogenous α1B-ARs are not detectable via either [3H]-prazosin binding analysis or phosphoinositol hydrolysis assays, their activation leads to robust DMR and enhanced cell viability...
February 14, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28193003/on-mass-ambiguities-in-high-resolution-shotgun-lipidomics
#7
Chris Bielow, Guido Mastrobuoni, Marica Orioli, Stefan Kempa
Mass-spectrometry-based lipidomics aims to identify as many lipid species as possible from complex biological samples. Due to the large combinatorial search space, unambiguous identification of lipid species is far from trivial. Mass ambiguities are common in direct-injection shotgun experiments, where an orthogonal separation (e.g., liquid chromatography) is missing. Using the rich information within available lipid databases, we generated a comprehensive rule set describing mass ambiguities, while taking into consideration the resolving power (and its decay) of different mass analyzers...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28185190/phenotyping-cd4-hth2-cells-by-flow-cytometry-simultaneous-detection-of-transcription-factors-secreted-cytokines-and-surface-markers
#8
Chris Goetz, Li-Jen Peng, Birte Aggeler, Jody Bonnevier
Flow cytometry is a powerful technique that allows simultaneous detection of multiple markers on a specific cell population. This method is virtually unlimited as long as the specimen of interest can be put into a single-cell suspension for staining and subsequent analysis by the flow cytometer. Most investigators using this methodology are doing so because their cell population is rare in frequency and requires multiple markers to characterize their population of interest; thus standard methods such as Western blot and IHC are unsuitable due to limitations in cell number and the number of markers available...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28177712/investigating-human-skeletal-muscle-physiology-with-unilateral-exercise-models-when-one-limb-is-more-powerful-than-two
#9
Martin J MacInnis, Chris McGlory, Martin J Gibala, Stuart M Phillips
Direct sampling of human skeletal muscle using the needle biopsy technique can facilitate insight into the biochemical and histological responses resulting from changes in exercise or feeding. However, the muscle biopsy procedure is invasive, and analyses are often expensive, which places pragmatic restraints on sample sizes. The unilateral exercise model can serve to increase statistical power and reduce the time and cost of a study. With this approach, two limbs of a participant are randomized to one of two treatments that can be applied almost concurrently or sequentially depending on the nature of the intervention...
January 24, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28162251/reliability-and-utility-of-citizen-science-reef-monitoring-data-collected-by-reef-check-australia-2002-2015
#10
Terence Done, Chris Roelfsema, Andrew Harvey, Laura Schuller, Jocelyn Hill, Marie-Lise Schläppy, Alexandra Lea, Anne Bauer-Civiello, Jennifer Loder
Reef Check Australia (RCA) has collected data on benthic composition and cover at >70 sites along >1000km of Australia's Queensland coast from 2002 to 2015. This paper quantifies the accuracy, precision and power of RCA benthic composition data, to guide its application and interpretation. A simulation study established that the inherent accuracy of the Reef Check point sampling protocol is high (<±7% error absolute), in the range of estimates of benthic cover from 1% to 50%. A field study at three reef sites indicated that, despite minor observer- and deployment-related biases, the protocol does reliably document moderate ecological changes in coral communities...
February 2, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28158196/transcriptome-wide-co-expression-analysis-identifies-lrrc2-as-a-novel-mediator-of-mitochondrial-and-cardiac-function
#11
Chris McDermott-Roe, Marion Leleu, Glenn C Rowe, Oleg Palygin, John D Bukowy, Judy Kuo, Monika Rech, Steffie Hermans-Beijnsberger, Sebastian Schaefer, Eleonora Adami, Esther E Creemers, Matthias Heinig, Blanche Schroen, Zoltan Arany, Enrico Petretto, Aron M Geurts
Mitochondrial dysfunction contributes to myriad monogenic and complex pathologies. To understand the underlying mechanisms, it is essential to define the full complement of proteins that modulate mitochondrial function. To identify such proteins, we performed a meta-analysis of publicly available gene expression data. Gene co-expression analysis of a large and heterogeneous compendium of microarray data nominated a sub-population of transcripts that whilst highly correlated with known mitochondrial protein-encoding transcripts (MPETs), are not themselves recognized as generating proteins either localized to the mitochondrion or pertinent to functions therein...
2017: PloS One
https://www.readbyqxmd.com/read/28157879/design-of-a-noncooled-fiber-collimator-for-compact-high-efficiency-fiber-laser-arrays
#12
Leonid A Beresnev, R Andrew Motes, Keith J Townes, Patrick Marple, Kristan Gurton, Anthony R Valenzuela, Chatt Williamson, Jony J Liu, Chris Washer
A high-power fiber laser collimator and array of collimators are described with optical architecture, allowing one to transmit almost 100% of the full power output from fiber facets. In the case of coherent beam combining, more than 70% of the full power can be focused into a diffraction limited spot determined by the diameter of the conformal aperture. The truncated-Gaussian beam tails are not trapped inside the array but are redirected through the output lenses and dispersed outside of the array along with the main collimated beam, thus eliminating the requirement for cooling the array...
January 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28155918/surface-mediated-cooperative-interactions-of-drugs-enhance-mechanical-forces-for-antibiotic-action
#13
Joseph W Ndieyira, Joe Bailey, Samadhan B Patil, Manuel Vögtli, Matthew A Cooper, Chris Abell, Rachel A McKendry, Gabriel Aeppli
The alarming increase of pathogenic bacteria that are resistant to multiple antibiotics is now recognized as a major health issue fuelling demand for new drugs. Bacterial resistance is often caused by molecular changes at the bacterial surface, which alter the nature of specific drug-target interactions. Here, we identify a novel mechanism by which drug-target interactions in resistant bacteria can be enhanced. We examined the surface forces generated by four antibiotics; vancomycin, ristomycin, chloroeremomycin and oritavancin against drug-susceptible and drug-resistant targets on a cantilever and demonstrated significant differences in mechanical response when drug-resistant targets are challenged with different antibiotics although no significant differences were observed when using susceptible targets...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28153336/genome-wide-regional-heritability-mapping-identifies-a-locus-within-the-tox2-gene-associated-with-major-depressive-disorder
#14
Yanni Zeng, Pau Navarro, Masoud Shirali, David M Howard, Mark J Adams, Lynsey S Hall, Toni-Kim Clarke, Pippa A Thomson, Blair H Smith, Alison Murray, Sandosh Padmanabhan, Caroline Hayward, Thibaud Boutin, Donald J MacIntyre, Cathryn M Lewis, Naomi R Wray, Divya Mehta, Brenda W J H Penninx, Yuri Milaneschi, Bernhard T Baune, Tracy Air, Jouke-Jan Hottenga, Hamdi Mbarek, Enrique Castelao, Giorgio Pistis, Thomas G Schulze, Fabian Streit, Andreas J Forstner, Enda M Byrne, Nicholas G Martin, Gerome Breen, Bertram Müller-Myhsok, Susanne Lucae, Stefan Kloiber, Enrico Domenici, Ian J Deary, David J Porteous, Chris S Haley, Andrew M McIntosh
BACKGROUND: Major depressive disorder (MDD) is the second largest cause of global disease burden. It has an estimated heritability of 37%, but published genome-wide association studies have so far identified few risk loci. Haplotype-block-based regional heritability mapping (HRHM) estimates the localized genetic variance explained by common variants within haplotype blocks, integrating the effects of multiple variants, and may be more powerful for identifying MDD-associated genomic regions...
December 16, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28151935/cannabinoid-antagonist-slv326-induces-convulsive-seizures-and-changes-in-the-interictal-eeg-in-rats
#15
Martin F J Perescis, Natasja de Bruin, Liesbeth Heijink, Chris Kruse, Lyudmila Vinogradova, Annika Lüttjohann, Gilles van Luijtelaar, Clementina M van Rijn
Cannabinoid CB1 antagonists have been investigated for possible treatment of e.g. obesity-related disorders. However, clinical application was halted due to their symptoms of anxiety and depression. In addition to these adverse effects, we have shown earlier that chronic treatment with the CB1 antagonist rimonabant may induce EEG-confirmed convulsive seizures. In a regulatory repeat-dose toxicity study violent episodes of "muscle spasms" were observed in Wistar rats, daily dosed with the CB1 receptor antagonist SLV326 during 5 months...
2017: PloS One
https://www.readbyqxmd.com/read/28147531/communication-improved-ab-initio-molecular-dynamics-by-minimally-biasing-with-experimental-data
#16
Andrew D White, Chris Knight, Glen M Hocky, Gregory A Voth
Accounting for electrons and nuclei simultaneously is a powerful capability of ab initio molecular dynamics (AIMD). However, AIMD is often unable to accurately reproduce properties of systems such as water due to inaccuracies in the underlying electronic density functionals. This shortcoming is often addressed by added empirical corrections and/or increasing the simulation temperature. We present here a maximum-entropy approach to directly incorporate limited experimental data via a minimal bias. Biased AIMD simulations of water and an excess proton in water are shown to give significantly improved properties both for observables which were biased to match experimental data and for unbiased observables...
January 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28146253/the-most-reasonable-explanation-of-the-dress-implicit-assumptions-about-illumination
#17
Christoph Witzel, Chris Racey, J Kevin O'Regan
Millions of Internet users around the world challenged science by asking why a certain photo of a dress led different observers to have surprisingly different judgments about the color of the dress. The reason this particular photo produces so diverse a variety of judgments presumably is that the photo allows a variety of interpretations about the illumination of the dress. The most obvious explanation from color science should be that observers have different implicit assumptions about the illumination in the photo...
February 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28144411/temporal-changes-in-technical-and-physical-performances-during-a-small-sided-game-in-elite-youth-soccer-players
#18
Alexandre Moreira, Marcelo Saldanha Aoki, Chris Carling, Rafael Alan Rodrigues Lopes, Ademir Felipe Schultz de Arruda, Marcelo Lima, Umberto Cesar Correa, Paul S Bradley
BACKGROUND: There have been claims that small-sided games (SSG) may generate an appropriate environment to develop youth players' technical performance associated to game-related problem solving. However, the temporal change in technical performance parameters of youth players during SSG is still unknown. OBJECTIVES: The aim of this study was to examine temporal changes in technical and physical performances during a small-sided game (SSG) in elite soccer players...
December 2016: Asian Journal of Sports Medicine
https://www.readbyqxmd.com/read/28139353/suspected-acs-patients-presenting-with-myocardial-damage-or-a-type-2-myocardial-infarction-have-a-similar-late-mortality-to-patients-with-a-type-1-myocardial-infarction-a-report-from-the-australian-and-new-zealand-2012-snapshot-acs-study
#19
Aisha Etaher, Derek Chew, Julie Redfern, Tom Briffa, Chris Ellis, Christopher Hammett, Jeffrey Lefkovits, John Elliott, Louise Cullen, David Brieger, John K French
BACKGROUND: Cardiac troponin (T and I) are considered the standard markers for detection of myocardial damage and the diagnosis of acute coronary syndrome (ACS) among patients who present to an emergency department with chest pain. However, these markers can be released in other situations and may be associated with short- and long-term clinical outcomes. In this study, we examine late mortality rates among patients presenting with a suspected ACS due to an unstable coronary plaque and those patients having a non-ACS...
December 31, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28137854/siberian-arctic-black-carbon-sources-constrained-by-model-and-observation
#20
Patrik Winiger, August Andersson, Sabine Eckhardt, Andreas Stohl, Igor P Semiletov, Oleg V Dudarev, Alexander Charkin, Natalia Shakhova, Zbigniew Klimont, Chris Heyes, Örjan Gustafsson
Black carbon (BC) in haze and deposited on snow and ice can have strong effects on the radiative balance of the Arctic. There is a geographic bias in Arctic BC studies toward the Atlantic sector, with lack of observational constraints for the extensive Russian Siberian Arctic, spanning nearly half of the circum-Arctic. Here, 2 y of observations at Tiksi (East Siberian Arctic) establish a strong seasonality in both BC concentrations (8 ng⋅m(-3) to 302 ng⋅m(-3)) and dual-isotope-constrained sources (19 to 73% contribution from biomass burning)...
January 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
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