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Chris Powers

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https://www.readbyqxmd.com/read/28442585/next-gen-sequencing-analysis-and-algorithms-for-pdx-and-cdx-models
#1
Garima Khandelwal, Maria Romina Girotti, Christopher Smowton, Sam Taylor, Chris Wirth, Marek Dynowski, Kristopher K Frese, Ged Brady, Caroline Dive, Richard Marais, Crispin Miller
Patient-derived xenograft (PDX) and CTC-derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions including the study of metastatic progression, genetic evolution and therapeutic drug responses. Since PDX and CDX models can recapitulate the highly heterogeneous characteristics of a patient tumor, as well as their response to chemotherapy, there is considerable interest in combining them with next-generation sequencing (NGS) in order to monitor the genomic, transcriptional, and epigenetic changes that accompany oncogenesis...
April 25, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28422968/the-impact-of-a-point-of-care-testing-device-on-cvd-risk-assessment-completion-in-new-zealand-primary-care-practice-a-cluster-randomised-controlled-trial-and-qualitative-investigation
#2
RANDOMIZED CONTROLLED TRIAL
Sue Wells, Natasha Rafter, Timothy Kenealy, Geoff Herd, Kyle Eggleton, Rose Lightfoot, Kim Arcus, Angela Wadham, Yannan Jiang, Chris Bullen
OBJECTIVES: To assess the effect of a point of care (POC) device for testing lipids and HbA1c in addition to testing by community laboratory facilities (usual practice) on the completion of cardiovascular disease (CVD) risk assessments in general practice. METHODS: We conducted a pragmatic, cluster randomised controlled trial in 20 New Zealand general practices stratified by size and rurality and randomised to POC device plus usual practice or usual practice alone (controls)...
2017: PloS One
https://www.readbyqxmd.com/read/28422663/a-neural-probe-with-up-to-966-electrodes-and-up-to-384-configurable-channels-in-0-13-%C3%AE-m-soi-cmos
#3
Carolina Mora Lopez, Jan Putzeys, Bogdan Cristian Raducanu, Marco Ballini, Shiwei Wang, Alexandru Andrei, Veronique Rochus, Roeland Vandebriel, Simone Severi, Chris Van Hoof, Silke Musa, Nick Van Helleputte, Refet Firat Yazicioglu, Srinjoy Mitra
In vivo recording of neural action-potential and local-field-potential signals requires the use of high-resolution penetrating probes. Several international initiatives to better understand the brain are driving technology efforts towards maximizing the number of recording sites while minimizing the neural probe dimensions. We designed and fabricated (0.13- μm SOI Al CMOS) a 384-channel configurable neural probe for large-scale in vivo recording of neural signals. Up to 966 selectable active electrodes were integrated along an implantable shank (70 μm wide, 10 mm long, 20  μm thick), achieving a crosstalk of [Formula: see text] dB...
April 14, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28409743/pet-neck-a-multicentre-randomised-phase-iii-non-inferiority-trial-comparing-a-positron-emission-tomography-computerised-tomography-guided-watch-and-wait-policy-with-planned-neck-dissection-in-the-management-of-locally-advanced-n2-n3-nodal-metastases-in-patients
#4
Hisham Mehanna, Chris C McConkey, Joy K Rahman, Wai-Lup Wong, Alison F Smith, Chris Nutting, Andrew Gj Hartley, Peter Hall, Claire Hulme, Dharmesh K Patel, Sandra Ventorin von Zeidler, Max Robinson, Bal Sanghera, Lydia Fresco, Janet A Dunn
BACKGROUND: Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histological evidence of tumour. Consequently, a significant proportion of clinicians still practise planned ND. Fludeoxyglucose positron emission tomography (PET)-computerised tomography (CT) scanning demonstrated high negative predictive values for persistent nodal disease, providing a possible alternative paradigm to ND...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28398212/effect-of-piezoelectric-substrate-on-phonon-drag-thermopower-in-monolayer-graphene
#5
Bhargavi Kalaenahalli, Shrishail S Kubakaddi, Chris Ford
The phonon-drag thermopower is studied in monolayer graphene on a piezoelectric substrate. The phonon-drag contribution S^g_PA from the extrinsic potential of piezoelectric surface acoustic (PA) phonons of a piezoelectric substrate (GaAs) is calculated as a function of temperature T and electron concentration n_s. At very low temperature, S^g_PA is found to be much greater than S^g_DA of the intrinsic deformation potential of acoustic (DA) phonons of the graphene. There is a crossover of S^g_PA and S^g_DA at around ~ 5 K...
April 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28398046/development-of-a-13c-nmr-chemical-shift-prediction-procedure-using-b3lyp-cc-pvdz-and-empirically-derived-systematic-error-correction-terms-a-computational-small-molecule-structure-elucidation-method
#6
Dongyue Xin, C Avery Sader, Om Choudhary, Paul-James Jones, Klaus Wagner, Christofer S Tautermann, Zheng Yang, Carl A Busacca, Reggie Saraceno, Keith R Fandrick, Nina C Gonnella, Keith Horspool, Gordon Hansen, Chris H Senanayake
An accurate and efficient procedure was developed for performing 13C NMR chemical shift calculations employing density functional theory with the gauge invariant atomic orbitals (DFT-GIAO). Benchmarking analysis was carried out, incorporating several density functionals and basis sets commonly used for prediction of 13C NMR chemical shifts, from which the B3LYP/cc-pVDZ level of theory was found to provide accurate results at low computational cost. Statistical analyses from a large data set of 13C NMR chemical shifts in DMSO are presented with TMS as the calculated reference and with empirical scaling parameters obtained from a linear regression analysis...
April 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28378896/a-comprehensive-assessment-of-immunophenotyping-performed-in-cryopreserved-peripheral-whole-blood
#7
Chris P Verschoor, Vikas Kohli, Cynthia Balion
BACKGROUND: Monitoring the frequency and phenotype of white blood cell subsets using flow cytometry (immunophenotyping) has proven to be an incredibly powerful tool in the assessment of health. Although improved technologies have aided in the practical implementation of immunophenotyping in clinical and epidemiological studies, the transportation of blood from the site of collection to a central laboratory for analysis within a reasonable timeframe may not be feasible. Hence, the purpose of the following study was to investigate the validity of cryopreserved whole blood as a simple to prepare and cost-effective biospecimen for multi-colour immunophenotyping in a large epidemiological study - namely, The Canadian Longitudinal Study on Aging (CLSA)...
April 5, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28369824/medial-gastrocnemius-and-soleus-muscle-tendon-unit-fascicle-and-tendon-interaction-during-walking-in-children-with-cerebral-palsy
#8
Lee Barber, Chris Carty, Luca Modenese, John Walsh, Roslyn Boyd, Glen Lichtwark
AIM: This study investigates the in vivo function of the medial gastrocnemius and soleus muscle-tendon units (MTU), fascicles, and tendons during walking in children with cerebral palsy (CP) and an equinus gait pattern. METHOD: Fourteen children with CP (9 males, 5 females; mean age 10y 6mo, standard deviation [SD] 2y 11mo; GMFCS level I=8, II=6), and 10 typically developing (6 males, 4 females; mean age 10y, SD 2y 1mo) undertook full body 3D gait analysis and simultaneous B-mode ultrasound images of the medial gastrocnemius and soleus fascicles during level walking...
April 1, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28369581/guild-guidance-for-information-about-linking-data-sets%C3%A2
#9
Ruth Gilbert, Rosemary Lafferty, Gareth Hagger-Johnson, Katie Harron, Li-Chun Zhang, Peter Smith, Chris Dibben, Harvey Goldstein
Record linkage of administrative and survey data is increasingly used to generate evidence to inform policy and services. Although a powerful and efficient way of generating new information from existing data sets, errors related to data processing before, during and after linkage can bias results. However, researchers and users of linked data rarely have access to information that can be used to assess these biases or take them into account in analyses. As linked administrative data are increasingly used to provide evidence to guide policy and services, linkage error, which disproportionately affects disadvantaged groups, can undermine evidence for public health...
March 28, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28363072/radiography-in-the-field-assessing-a-lightweight-handheld-battery-powered-dentistry-unit-for-field-diagnostic-applications
#10
Katharina Seilern-Moy, Hanna Vielgrader, Hanno Gerritsmann, Chris Walzer
Radiography units are not used commonly in wildlife medicine field settings, primarily because of their weight and requirement for a power supply. In this study, a portable, battery-powered, and lightweight radiography unit, originally developed for dentistry, was assessed for its potential field applications. Radiographs of various animal species (ranging in weight from 14 g to 1,000 kg) were imaged using varying source image distance (SID) and exposure time. The quality of these images was evaluated for their resolution, image noise, and motion blur...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28344446/prediction-of-tennis-performance-in-junior-elite-tennis-players
#11
Tamara Kramer, Barbara C H Huijgen, Marije T Elferink-Gemser, Chris Visscher
Predicting current and future tennis performance can lead to improving the development of junior tennis players. The aim of this study is to investigate whether age, maturation, or physical fitness in junior elite tennis players in U13 can explain current and future tennis performance. The value of current tennis performance for future tennis performance is also investigated. A total of 86 junior elite tennis players (boys, n = 44; girls, n = 42) U13 (aged: 12.5 ± 0.3 years), and followed to U16, took part in this study...
March 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28343006/trouble-on-takeoff-crude-oil-on-feathers-reduces-escape-performance-of-shorebirds
#12
Ivan Maggini, Lisa V Kennedy, Kyle H Elliott, Karen M Dean, Robert MacCurdy, Alexander Macmillan, Chris A Pritsos, Christopher G Guglielmo
The ability to takeoff quickly and accelerate away from predators is crucial to bird survival. Crude oil can disrupt the fine structure and function of feathers, and here we tested for the first time how small amounts of oil on the trailing edges of the wings and tail of Western sandpipers (Calidris mauri) affected takeoff flight performance. In oiled birds, the distance travelled during the first 0.4s after takeoff was reduced by 29%, and takeoff angle was decreased by 10° compared to unoiled birds. Three-axis accelerometry indicated that oiled sandpipers produced less mechanical power output per wingbeat during the initial phase of flight...
March 23, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28336563/complex-multifault-rupture-during-the-2016-mw-7-8-kaik%C3%A5-ura-earthquake-new-zealand
#13
Ian J Hamling, Sigrun Hreinsdóttir, Kate Clark, John Elliott, Cunren Liang, Eric Fielding, Nicola Litchfield, Pilar Villamor, Laura Wallace, Tim J Wright, Elisabetta D'Anastasio, Stephen Bannister, David Burbidge, Paul Denys, Paula Gentle, Jamie Howarth, Christof Mueller, Neville Palmer, Chris Pearson, William Power, Philip Barnes, David J A Barrell, Russ Van Dissen, Robert Langridge, Tim Little, Andrew Nicol, Jarg Pettinga, Julie Rowland, Mark Stirling
On 14th November 2016, the northeastern South Island of New Zealand was struck by a major Mw 7.8 earthquake. Field observations, in conjunction with InSAR, GPS, and seismology reveal this to be one of the most complex earthquakes ever recorded. The rupture propagated northward for more than 170 km along both mapped and unmapped faults, before continuing offshore at its northeastern extent. Geodetic and field observations reveal surface ruptures along at least 12 major faults, including possible slip along the southern Hikurangi subduction interface, extensive uplift along much of the coastline and widespread anelastic deformation including the ~8 m uplift of a fault-bounded block...
March 23, 2017: Science
https://www.readbyqxmd.com/read/28332636/significantly-enhanced-energy-storage-density-by-modulating-the-aspect-ratio-of-batio3-nanofibers
#14
Dou Zhang, Xuefan Zhou, James Roscow, Kechao Zhou, Lu Wang, Hang Luo, Chris R Bowen
There is a growing need for high energy density capacitors in modern electric power supplies. The creation of nanocomposite systems based on one-dimensional nanofibers has shown great potential in achieving a high energy density since they can optimize the energy density by exploiting both the high permittivity of ceramic fillers and the high breakdown strength of the polymer matrix. In this paper, BaTiO3 nanofibers (NFs) with different aspect ratio were synthesized by a two-step hydrothermal method and the permittivity and energy storage of the P(VDF-HFP) nanocomposites were investigated...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28329279/performance-of-hospitals-according-to-the-esc-acca-quality-indicators-and-30-day-mortality-for-acute-myocardial-infarction-national-cohort-study-using-the-united-kingdom-myocardial-ischaemia-national-audit-project-minap-register
#15
Owen Bebb, Marlous Hall, Keith A A Fox, Tatendashe B Dondo, Adam Timmis, Hector Bueno, François Schiele, Chris P Gale
Aims: To investigate the application of the European Society of Cardiology Acute Cardiovascular Care Association quality indicators (QI) for acute myocardial infarction for the study of hospital performance and 30-day mortality. Methods and results: National cohort study (n = 118,075 patients, n = 211 hospitals, MINAP registry), 2012-13. Overall, 16 of the 20 QIs could be calculated. Eleven QIs had a significant inverse association with GRACE risk adjusted 30-day mortality (all P < 0...
April 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28317276/important-considerations-in-lesion-symptom-mapping-illustrations-from-studies-of-word-comprehension
#16
Hinna Shahid, Rajani Sebastian, Tatiana T Schnur, Taylor Hanayik, Amy Wright, Donna C Tippett, Julius Fridriksson, Chris Rorden, Argye E Hillis
Lesion-symptom mapping is an important method of identifying networks of brain regions critical for functions. However, results might be influenced substantially by the imaging modality and timing of assessment. We tested the hypothesis that brain regions found to be associated with acute language deficits depend on (1) timing of behavioral measurement, (2) imaging sequences utilized to define the "lesion" (structural abnormality only or structural plus perfusion abnormality), and (3) power of the study. We studied 191 individuals with acute left hemisphere stroke with MRI and language testing to identify areas critical for spoken word comprehension...
March 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28300572/the-potential-role-of-aspiration-in-the-asthmatic-airway
#17
Eoin B Hunt, Chris Ward, Stephen Power, Ashley Sullivan, Jeffrey Pearson, Susan Lapthorne, Paul M O'Byrne, Joseph Eustace, Barry J Plant, Michael M Maher, John MacSharry, Desmond M Murphy
BACKGROUND: Many asthmatics remain sub-optimally controlled despite current treatments. Reasons include comorbidities that could aggravate asthma, including gastro-esophageal reflux (GER). We aimed to investigate whether aspiration occurs in asthmatic patients and if so does it correlate with asthma control. METHODS: Patients had ACQ-7, FeNO, and spirometry performed to characterize their level of asthma control. Barium swallow with provocation was performed to assess for predisposition to aspiration...
March 11, 2017: Chest
https://www.readbyqxmd.com/read/28283424/modelling-plankton-ecosystems-in-the-meta-omics-era-are-we-ready
#18
REVIEW
Krzysztof Franciszek Stec, Luigi Caputi, Pier Luigi Buttigieg, Domenico D'Alelio, Federico Matias Ibarbalz, Matthew B Sullivan, Samuel Chaffron, Chris Bowler, Maurizio Ribera d'Alcalà, Daniele Iudicone
Recent progress in applying meta-omics approaches to the study of marine ecosystems potentially allows scientists to study the genetic and functional diversity of plankton at an unprecedented depth and with enhanced precision. However, while a range of persistent technical issues still need to be resolved, a much greater obstacle currently preventing a complete and integrated view of the marine ecosystem is the absence of a clear conceptual framework. Herein, we discuss the knowledge that has thus far been derived from conceptual and statistical modelling of marine plankton ecosystems, and illustrate the potential power of integrated meta-omics approaches in the field...
March 7, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28268856/covariance-based-outlier-detection-with-feature-selection
#19
Chris E Zwilling, Michelle Y Wang
The present covariance based outlier detection algorithm selects from a candidate set of feature vectors that are best at identifying outliers. Features extracted from biomedical and health informatics data can be more informative in disease assessment and there are no restrictions on the nature and number of features that can be tested. But an important challenge for an algorithm operating on a set of features is for it to winnow the effective features from the ineffective ones. The powerful algorithm described in this paper leverages covariance information from the time series data to identify features with the highest sensitivity for outlier identification...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262725/a-microrna-initiated-dnazyme-motor-operating-in-living-cells
#20
Hanyong Peng, Xing-Fang Li, Hongquan Zhang, X Chris Le
Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target. The whole motor system is constructed on a 20 nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP...
March 6, 2017: Nature Communications
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