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Cancer cells AND Lactic acid

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https://www.readbyqxmd.com/read/29782350/effect-of-pyruvate-kinase-m2-regulating-aerobic-glycolysis-on-chemotherapy-resistance-of-estrogen-receptor-positive-breast-cancer
#1
Yuejun Qian, Lina Bi, Yingxu Yang, Dong Wang
This study aims to explore the effect and mechanism of pyruvate kinase M2 (PKM2) on chemotherapy resistance of estrogen receptor-positive breast cancer (ER BC) by regulating aerobic glycolysis. The expression of PKM2 in ER BC MCF-7 cells, T47D cells and MCF-7/ADR cells (which are subject to adriamycin/ADR induction) were determined by quantitative real-time PCR and western blot. MCF-7/ADR (M/A) cells were grouped into blank group (M/A), negative group (M/A+NC), low expression of PKM2 group (M/A+si-PKM2 group), overexpression of PKM2 group (M/A+PKM2 group) and glycolysis inhibition group (M/A+PKM2+2-DG group)...
May 18, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29778872/derivatization-method-for-the-quantification-of-lactic-acid-in-cell-culture-media-via-gas-chromatography-and-applications-in-the-study-of-cell-glycometabolism
#2
Hua-Yin Zhang, Ping-Ping Zhang, Xiao-Xin Tan, Ze-Ze Wang, Kao-Qi Lian, Xiang-Dong Xu, Wei-Jun Kang
Lactic acid represents an important metabolite that reflects mitochondria function and may further serve as energy source for cancer cells. In light of this physiological and pathological significance, we developed a novel and sensitive gas chromatography method to detect lactic acid in cell culture media. Here, ethyl chloroformate was selected as derivative reagent and the derivatization process was further optimized in terms of number of reagents and reaction time as well as extraction reagents. Under optimal conditions, good linearity was achieved in the tested calibration range...
May 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29778525/mucus-penetrating-nanoparticles-promising-drug-delivery-systems-for-the-photodynamic-therapy-of-intestinal-cancer
#3
Juliane Anderski, Laura Mahlert, Dennis Mulac, Klaus Langer
Photodynamic therapy (PDT) is an auspicious therapy approach for the treatment of cancer. Despite its numerous benefits, the drug delivery of the used photosensitizer (PS) to target locations inside the human body remains a main therapy challenge, since the standard intravenous PS injection often causes systemic side-effects. To circumvent this therapy drawback, the oral application represents a promising administration alternative. Especially for the treatment of intestinal cancer it offers the possibility of a local treatment with a reduced likelihood for adverse drug reactions...
May 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29772209/prolyl-hydroxylase-2-a-promising-target-to-inhibit-hypoxia-induced-cellular-metabolism-in-cancer-cells
#4
REVIEW
Lakhveer Singh, Sara Aldosary, Abdulaziz S Saeedan, M Nazam Ansari, Gaurav Kaithwas
Hypoxia-inducible factor-1α (HIF-1α) shifts the metabolism of glucose from highly efficient oxidative phosphorylation to less efficient glycolysis. Pyruvic acid thus accumulated is oxidized to lactic acid which is pumped out in the tumor microenvironment. Protons generated from the pentose phosphate pathway (PPP) and upon hydrolysis of ATP further enhance the acidity in the tumor microenvironment. The resultant pH in the tumor microenvironment activates an endoplasmic reticulum protein: sterol regulatory element binding protein-1c (SREBP-1c), which once activated enhances proliferation of the tumor cell...
May 14, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29770812/reduction-photo-dual-responsive-polymeric-prodrug-nanoparticles-for-programmed-sirna-and-doxorubicin-delivery
#5
Ming Wu, Jiong Li, Xinyi Lin, Zuwu Wei, Da Zhang, Bixing Zhao, Xiaolong Liu, Jingfeng Liu
Dual and multi-stimuli responsive polymeric nanoparticles that respond to two or more signals can further improve drug release performance compared with nanoparticles that respond to a single stimulus. However, usage of such nanoparticles to deliver siRNA and chemotherapeutic drugs in a sequential manner are currently very rare; meanwhile, this technology is vital to optimize the efficacy of chemotherapy towards cancer cells with multidrug resistance. By loading o-nitrobenzyl ester derivative caged DOX (DOC) into the inner poly(lactic-co-glycolic acid) (PLGA) core and adsorbing siRNA of P-gp protein onto the cationic polymeric shell derived from a disulfide-containing alkyl modified polyethylenimine (C16-S-S-PEI), here, a reduction/photo dual responsive device (RPDRD) is successfully designed for programmed P-gp siRNA and doxorubicin delivery...
May 17, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29762617/anticancer-potential-against-cervix-cancer-hela-cell-line-of-probiotic-lactobacillus-casei-and-lactobacillus-paracasei-strains-isolated-from-human-breast-milk
#6
Muhammad Shahid Riaz Rajoka, Haobin Zhao, Yao Lu, Ziyang Lian, Na Li, Nazim Hussain, Dongyan Shao, Mingliang Jin, Qi Li, Junling Shi
Lactic acid bacteria have been categorized as probiotics and play a crucial role in human health by stimulating the supply of nutrients, shaping the immune system, and preventing the colonization of pathogenic microbes. This study investigated the mechanisms for the action of three potential probiotic Lactobacillus strains: Lactobacillus casei SR1, Lactobacillus casei SR2, and Lactobacillus paracasei SR4 isolated from human breast milk. These Lactobacillus strains were identified via 16S DNA sequencing and characterized via biochemical assays including acid resistance, bile resistance, antioxidant activity, and antibiotic susceptibility...
May 15, 2018: Food & Function
https://www.readbyqxmd.com/read/29760743/crosstalk-between-the-warburg-effect-redox-regulation-and-autophagy-induction-in-tumourigenesis
#7
REVIEW
Mokgadi Violet Gwangwa, Anna Margaretha Joubert, Michelle Helen Visagie
Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ago. Furthermore, increased reactive oxygen species (ROS) and lactate quantities increase metabolic, survival and proliferation signalling, resulting in increased tumourigenesis. In order to maintain redox balance, the cell possesses innate antioxidant defence systems such as superoxide dismutase, catalase and glutathione...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29758233/longitudinal-assessment-of-ultrasound-guided-complementary-microrna-therapy-of-hepatocellular-carcinoma
#8
Sayan Mullick Chowdhury, Taehwa Lee, Sunitha V Bachawal, Rammohan Devulapally, Lotfi Abou-Elkacem, Tristan Alan Yeung, Jennifer Wischhusen, Lu Tian, Jeremy Dahl, Ramasamy Paulmurugan, Jürgen Karl Willmann
Hepatocellular carcinoma (HCC) is the second-leading cause of cancer related deaths worldwide and new strategies to efficiently treat HCC are critically needed. The aim of this study was to assess the longitudinal treatment effects of two complementary miRNAs (miRNA-122 and antimiR-21) encapsulated in biodegradable poly lactic-co-glycolic acid (PLGA) - poly ethylene glycol (PEG) nanoparticles (PLGA-PEG-NPs), administered by an ultrasound-guided and microbubble-mediated delivery approach in doxorubicin-resistant and non-resistant human HCC xenografts...
May 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29753950/structure-of-the-lps-o-chain-from-fusobacterium-nucleatum-strain-mjr-7757-b
#9
Evgeny Vinogradov, Frank St Michael, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and still births. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report the following structure of the lipopolysaccharide O-chain of F. nucleatum strain MJR 7757 B:where Lac is (R)-1-carboxyethyl (lactic acid residue); all monosaccharides are in the pyranose form...
April 25, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/29749303/ptx-loaded-three-layer-plga-cs-alg-nanoparticle-based-on-layer-by-layer-method-for-cancer-therapy
#10
Fang Wang, Jian Yuan, Qian Zhang, Siqian Yang, Shaohua Jiang, Chaobo Huang
Poly (lactic-co-glycolic acid) (PLGA) nanoparticles are an ideal paclitaxel (PTX)-carrying system due to its biocompatibility and biodegradability. But it possessed disadvantage of drug burst release. In this research, a layer-by-layer deposition of chitosan (CS) and sodium alginate (ALG) was applied to modify the PLGA nanoparticles. The surface charges and morphology of the PLGA, PLGA/CS and PLGA/CS/ALG particles was measured by capillary electrophoresis and SEM and TEM, respectively. The drug encapsulation and loading efficiency were confirmed by ultraviolet spectrophotometer...
May 11, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29737161/anti-cancer-and-anti-migration-effects-of-combinatorial-treatment-with-5-fluorouracil-and-lactobacillus-paracasei-subsp-paracasei-ntu-101-fermented-skim-milk-extracts-on-colorectal-cancer-cells
#11
Chia-Yuan Chang, Tzu-Ming Pan
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Metabolites of lactic acid bacteria (LAB) have anti-cancer and anti-metastasis capacity. This study aimed to investigate the chemotherapeutic combination effect of Lactobacillus paracasei subsp. paracasei NTU 101-fermented skim milk (NTU101-FM) extracts and the chemotherapeutic drug 5-fluorouracil (5-FU) in a cellular CRC model. NTU101-FM extracts effectively reduced CRC cell viability but was not cytotoxic to colon epithelial cells. Moreover, they increased RAW 264...
May 8, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29725407/the-enhanced-delivery-of-salinomycin-to-cd133-ovarian-cancer-stem-cells-through-cd133-antibody-conjugation-with-poly-lactic-co-glycolic-acid-poly-ethylene-glycol-nanoparticles
#12
Yi Mi, Yuqin Huang, Jie Deng
Ovarian cancer is the most lethal gynecologic malignancy, and ovarian cancer stem cells (CSCs) serve a pivotal function in the metastasis and recurrence of ovarian cancer. Multiple previous studies have validated CD133 as a marker of ovarian CSCs. Although salinomycin is a promising therapeutic agent that has been demonstrated to kill CSCs in various types of cancer, poor aqueous solubility hampers its clinical application. The present study used salinomycin-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles conjugated with CD133 antibodies (CD133-SAL-NP) to eliminate CD133+ ovarian CSCs...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29695174/preparation-of-psoralen-polymer-lipid-hybrid-nanoparticles-and-their-reversal-of-multidrug-resistance-in-mcf-7-adr-cells
#13
Qingqing Huang, Tiange Cai, Qianwen Li, Yinghong Huang, Qian Liu, Bingyue Wang, Xi Xia, Qi Wang, John C C Whitney, Susan P C Cole, Yu Cai
Multidrug resistance (MDR) is the leading cause of failure for breast cancer in the clinic. Thus far, polymer-lipid hybrid nanoparticles (PLN) loaded chemotherapeutic agents has been used to overcome MDR in breast cancer. In this study, we prepared psoralen polymer-lipid hybrid nanoparticles (PSO-PLN) to reverse drug resistant MCF-7/ADR cells in vitro and in vivo. PSO-PLN was prepared by the emulsification evaporation-low temperature solidification method. The formulation, water solubility and bioavailability, particle size, zeta potential and entrapment efficiency, and in vitro release experiments were optimized in order to improve the activity of PSO to reverse MDR...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29685122/treatment-of-pancreatic-ductal-adenocarcinoma-with-tumor-antigen-specific-targeted-delivery-of-paclitaxel-loaded-plga-nanoparticles
#14
Shu-Ta Wu, Anthony J Fowler, Corey B Garmon, Adam B Fessler, Joshua D Ogle, Kajal R Grover, Bailey C Allen, Chandra D Williams, Ru Zhou, Mahboubeh Yazdanifar, Craig A Ogle, Pinku Mukherjee
BACKGROUND: Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancers with a 5-year survival below 10%. Systemic delivery of chemotherapy drugs has severe side effects in patients with PDA and does not significantly improve overall survival rate. It is highly desirable to advance the therapeutic efficacy of chemotherapeutic drugs by targeting their delivery and increasing accumulation at the tumor site. MUC1 is a membrane-tethered glycoprotein that is aberrantly overexpressed in > 80% of PDA thus making it an attractive antigenic target...
April 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29664420/controlled-release-of-18-%C3%AE-glycyrrhetic-acid-by-nanodelivery-systems-increases-cytotoxicity-on-oral-carcinoma-cell-line
#15
Ilaria Cacciotti, Laura Chronopoulou, Cleofe Palocci, Adriana Amalfitano, Monica Cantiani, Massimo Cordaro, Carlo Lajolo, Cinzia Callà, Alma Boninsegna, Donatella Lucchetti, Patrizia Gallenzi, Alessandro Sgambato, Giuseppina Nocca, Alessandro Arcovito
The topical treatment for oral mucosal diseases is often based on products optimized for dermatologic applications; consequently, a lower therapeutic effect may be present.
 18-β-Glycyrrhetic Acid (GA) is extracted from Glycirrhiza glabra. The first aim of this study was to test the cytotoxicity of GA on PE/CA-PJ15 cells. The second aim was to propose and test two different delivery systems, i.e. nanoparticles and fibers, to guarantee a controlled release of GA in vitro. We used chitosan and poly(lactic-co-glycolic) acid based nanoparticles and polylactic acid fibers...
April 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29663927/encapsulation-of-5-flurouracil-into-plga-nanofibers-and-enhanced-anticancer-effect-in-combination-with-ajwa-dates-extract-phoenix-dactylifera-l
#16
Fazal Khan, Musab Aldhahri, Mohammad Asif Hussain, Kalamegam Gauthaman, Adnan Memic, Adel Abuzenadah, Taha Kumosani, Elie Barbour, Nazeeh Shuja Alothmany, Rabah Wasil Aldhaheri
Side effects connected with chemotherapeutic agents used in cancer treatment has led to alternative modalities of combinatorial therapies in an attempt to reduce the drug dosage and associated risks. In the current study we evaluated the potential use of Ajwa Dates Extract (ADE), reported to have anti-cancer effects, as an adjuvant therapy in combination with 5-flurouracil (5FU) against the human-breast-adenocarcinoma cell line (MFC-7) in vitro. The effects of ADE alone and in combination with 5-FU were evaluated in terms of cell viability and cytotoxicity...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29662176/cancer-cell-secreted-exosomal-mir-105-promotes-tumour-growth-through-the-myc-dependent-metabolic-reprogramming-of-stromal-cells
#17
Wei Yan, Xiwei Wu, Weiying Zhou, Miranda Y Fong, Minghui Cao, Juan Liu, Xiaojing Liu, Chih-Hong Chen, Oluwole Fadare, Donald P Pizzo, Jiawen Wu, Liang Liu, Xuxiang Liu, Andrew R Chin, Xiubao Ren, Yuan Chen, Jason W Locasale, Shizhen Emily Wang
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and buffer the negative effects of environmental changes. Extracellular microRNAs (miRNAs) have recently been implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-cancer-secreted, extracellular-vesicle-encapsulated miR-105, which is induced by the oncoprotein MYC in cancer cells and, in turn, activates MYC signalling in cancer-associated fibroblasts (CAFs) to induce a metabolic program...
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29619850/salinomycin-nanoparticles-interfere-with-tumor-cell-growth-and-the-tumor-microenvironment-in-an-orthotopic-model-of-pancreatic-cancer
#18
Zahra Daman, Homa Faghihi, Hamed Montazeri
Recently, Salinomycin (SAL) has been reported to inhibit proliferation and induce apoptosis in various tumors. The aim of this study was to deliver SAL to orthotopic model of pancreatic cancer by the aid of poly (lactic-co-glycolic acid) (PLGA) nanoparticles. The nanoparticles were physico-chemically characterized and evaluated for cytotoxicity on Luciferase-transduced AsPC-1 cells in vitro as well as implanted orthotopically into the pancreas of nude mice. SAL (3.5 mg/kg every other day) blocked tumor growth by 52% compared to the control group after 3 weeks of therapy...
April 5, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29617063/folate-conjugated-polymeric-micelle-hb-loaded-on-targeting-effect-by-intraperitoneal-to-ovarian-cancer-in-vitro-and-in-vivo
#19
Jie Li, Shu Yao, Kai Wang, Zaijun Lu, Xuantao Su, Li Li, Cunzhong Yuan, Jinbo Feng, Shi Yan, Beihua Kong, Kun Song
Photodynamic therapy (PDT) is considered as an innovative and attractive modality to treat ovarian cancer. In this study, a biodegradable polymer poly (ethylene glycol)-poly (lactic acid)(PLA)-folate (FA-PEG-PLA) was prepared in order to synthesize an active targeting, water soluble and pharmacomodulated photosensitizer nano-carriers. The drug loading content, encapsulation efficiency, in vitro and in vivo release were characterized, in which HB/FA-PEG-PLA micelles had a high encapsulation efficiency and much slower control release for drugs compared to free drugs (p<0...
April 4, 2018: Cancer Science
https://www.readbyqxmd.com/read/29606871/ultrasound-molecular-imaging-of-breast-cancer-in-mcf-7-orthotopic-mice-using-gold-nanoshelled-poly-lactic-co-glycolic-acid-nanocapsules-a-novel-dual-targeted-ultrasound-contrast-agent
#20
Li Xu, Jing Du, Caifeng Wan, Yu Zhang, Shaowei Xie, Hongli Li, Hong Yang, Fenghua Li
Background: The development of nanoscale molecularly targeted ultrasound contrast agents (UCAs) with high affinity and specificity is critical for ultrasound molecular imaging in the early detection of breast cancer. Purpose: To prospectively evaluate ultrasound molecular imaging with dual-targeted gold nanoshelled poly(lactide-co-glycolic acid) nanocapsules carrying vascular endothelial growth factor receptor type 2 (VEGFR2) and p53 antibodies (DNCs) in MCF-7 orthotopic mice model...
2018: International Journal of Nanomedicine
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