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Wenckebach

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https://www.readbyqxmd.com/read/27909484/lyme-arrhythmia-in-an-avid-golfer-a-diagnostic-challenge-and-a-therapeutic-dilemma
#1
Ujjwal Rastogi, Dr Nidhi Kumars
Lyme disease is a multisystem disorder affecting dermatologic, cardiac, nervous and musculoskeletal systems. Cardiac manifestations occur in about 5% of Lyme infections and stem from the involvement of the cardiac conduction system, resulting in varying degrees of sino-atrioventricular block. Occasionally, Lyme infection may also present with myopericarditis. Unlike isolated conduction node disease, myocardial involvement presents a great diagnostic and therapeutic dilemma for the physician. We report the case of a 68 year-old male cardiologist who presented with new onset exertional dyspnea and palpitations...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27886613/computed-tomography-is-important-in-appropriately-diagnosing-patients-with-third-degree-atrioventricular-block-and-second-degree-atrioventricular-block-but-not-wenckebach-type
#2
Hiroyuki Takaoka, Nobusada Funabashi, Koya Ozawa, Masae Uehara, Marehiko Ueda, Takuro Horikoshi, Takashi Uno, Yoshio Kobayashi
PURPOSE: To evaluate CT utility for detection of cardiac or lung abnormalities in the diagnosis of organic cardiac disease in subjects with second- or third-degree atrioventricular block (AVB) excepting Wenckebach type. MATERIALS AND METHODS: A total of 50 consecutive patients (25 male; 64±15years) with de novo third- or second-degree AVB underwent both TTE and a combination of cardiac and chest 320 slice CT (Aquilion one, Toshiba Medical) and were retrospectively analyzed...
November 11, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27594686/complex-and-interacting-influences-of-the-autonomic-nervous-system-on-cardiac-electrophysiology-in-conscious-mice
#3
Heidi L Lujan, Joshua P Rivers, Stephen E DiCarlo
Mice may now be the preferred animal model for biomedical research due to its anatomical, physiological, and genetic similarity to humans. However, little is known about accentuated antagonism of chronotropic and dromotropic properties in conscious mice. Accordingly, we describe the complex and interacting influence of the autonomic nervous system on cardiac electrophysiology in conscious mice. Specifically, we report the effects of single and combined cardiac autonomic blockade on measurements of pulse interval (heart rate), atrio-ventricular interval, sinus node recovery time (SNRT), SNRT corrected for spontaneous sinus cycle, and Wenckebach cycle length in conscious mice free of the confounding influences of anesthetics and surgical trauma...
December 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27585419/second-degree-atrioventricular-block-occurring-after-tooth-extraction
#4
Takaaki Kamatani, Ayako Akizuki, Seiji Kondo, Tatsuo Shirota
Although cardiac arrhythmias are occasionally associated with dental extractions and dental anesthesia, atrioventricular block is rarely seen during dental procedures. We report a rare case of type I second-degree atrioventricular block (Wenckebach phenomenon) occurring after bilateral extraction of impacted mandibular third molars under general anesthesia in a 16-year-old Japanese girl. Under consultation with a cardiovascular physician, we carefully monitored the patient's vital signs postoperatively, including blood pressure, oxygen saturation, and electrocardiogram, using a bedside monitor...
2016: Anesthesia Progress
https://www.readbyqxmd.com/read/27384223/global-alternans-instability-and-its-effect-on-non-linear-wave-propagation-dynamical-wenckebach-block-and-self-terminating-spiral-waves
#5
Nele Vandersickel, Arne Defauw, Peter Dawyndt, Alexander V Panfilov
The main mechanism of formation of reentrant cardiac arrhythmias is via formation of waveblocks at heterogeneities of cardiac tissue. We report that heterogeneity and the area of waveblock can extend itself in space and can result formation of new additional sources, or termination of existing sources of arrhythmias. This effect is based on a new form of instability, which we coin as global alternans instability (GAI). GAI is closely related to the so-called (discordant) alternans instability, however its onset is determined by the global properties of the APD-restitution curve and not by its slope...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27117805/pharmacological-inhibition-of-ik1-by-pa-6-in-isolated-rat-hearts-affects-ventricular-repolarization-and-refractoriness
#6
Mark A Skarsfeldt, Helena Carstensen, Lasse Skibsbye, Chuyi Tang, Rikke Buhl, Bo H Bentzen, Thomas Jespersen
The inwardly rectifying potassium current (IK 1) conducted through Kir2.X channels contribute to repolarization of the cardiac action potential and to stabilization of the resting membrane potential in cardiomyocytes. Our aim was to investigate the effect of the recently discovered IK 1 inhibitor PA-6 on action potential repolarization and refractoriness in isolated rat hearts. Transiently transfected HEK-293 cells expressing IK 1 were voltage-clamped with ramp protocols. Langendorff-perfused heart experiments were performed on male Sprague-Dawley rats, effective refractory period, Wenckebach cycle length, and ventricular effective refractory period were determined following 200 nmol/L PA-6 perfusion...
April 2016: Physiological Reports
https://www.readbyqxmd.com/read/27098002/electrical-remodeling-of-the-atrioventricular-node-caused-by-persistent-atrial-fibrillation-in-humans
#7
Akinori Sairaku, Yukiko Nakano, Kazuyoshi Suenari, Takehito Tokuyama, Hiroshi Kawazoe, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Yasuki Kihara
BACKGROUND: An animal experiment showed that long-term atrial pacing or persistent atrial fibrillation (AF) caused electrical remodeling of the atrioventricular (AV) node. We aimed to test the hypothesis that persistent AF decreases the AV conductivity in human hearts. METHODS AND RESULTS: We retrospectively compared the cardiac electrophysiological properties between patients with paroxysmal AF who underwent catheter ablation (PXAF, N = 254) and those with persistent or longstanding persistent AF (PSAF, N = 213)...
August 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27094587/wide-qrs-complex-tachycardia-in-a-patient-with-concealed-accessory-pathway-what-is-the-mechanism
#8
Marek Jastrzebski, Maciej Pitak, Andrzej Rudzinski, Danuta Czarnecka
No abstract text is available yet for this article.
September 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27064645/heart-specific-overexpression-of-the-human-short-clc-3-chloride-channel-isoform-limits-myocardial-ischemia-induced-erp-and-qt-prolongation
#9
Ying Yu, Linda Ye, Yi-Gang Li, Dean J Burkin, Dayue Darrel Duan
INTRODUCTION: Ischemia causes myocardial infarction and arrhythmias. Up-regulation of cardiac CLC-3 chloride channels is important for ischemic preconditioning-induced second-window protection against myocardial infarction. But its consequences in ischemia-induced electrical remodeling are still unknown. METHODS: The recently-characterized heart-specific overexpression of human short CLC-3 isoform (hsCLC-3(OE)) mice was used to study the effects of CLC-3 up-regulation on cardiac electrophysiology under ischemia/reperfusion conditions...
July 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27021518/prolongation-of-atrio-ventricular-node-conduction-in-a-rabbit-model-of-ischaemic-cardiomyopathy-role-of-fibrosis-and-connexin-remodelling
#10
Ashley M Nisbet, Patrizia Camelliti, Nicola L Walker, Francis L Burton, Stuart M Cobbe, Peter Kohl, Godfrey L Smith
Conduction abnormalities are frequently associated with cardiac disease, though the mechanisms underlying the commonly associated increases in PQ interval are not known. This study uses a chronic left ventricular (LV) apex myocardial infarction (MI) model in the rabbit to create significant left ventricular dysfunction (LVD) 8weeks post-MI. In vivo studies established that the PQ interval increases by approximately 7ms (10%) with no significant change in average heart rate. Optical mapping of isolated Langendorff perfused rabbit hearts recapitulated this result: time to earliest activation of the LV was increased by 14ms (16%) in the LVD group...
May 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/26972302/hyperhomocysteinemia-alters-sinoatrial-and-atrioventricular-nodal-function-role-of-magnesium-in-attenuating-these-effects
#11
Chirag V Soni, Suresh C Tyagi, Nathan D Todnem, Srikanth Givvimani, Sathnur B Pushpakumar, Juan Villafane, Claudio Maldonado
Patients with hyperhomocysteinemia (HHcy), or elevated plasma homocysteine (Hcy), are at higher risk of developing arrhythmias and sudden cardiac death; however, the mechanisms are unknown. In this study, the effects of HHcy on sinus node function, atrioventricular conduction, and ventricular vulnerability were investigated by electrophysiological (EP) analysis, and the role of magnesium (Mg(2+)), an endogenous N-methyl-D-aspartate (NMDA) receptor antagonist, in attenuating EP changes due to HHcy was explored...
March 2016: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/26920166/diagnostic-and-prognostic-implications-of-surface-recordings-from-patients-with-atrioventricular-block
#12
REVIEW
William P Nelson
The atrioventricular (AV) bridge is vulnerable to many circumstances that depress conduction. Abnormal impulse transmission may be caused by drugs, autonomic effects, or destructive processes. Type 1 (Wenckebach) AV block is owing to depressed AV nodal conduction and is recognized by a prolonging PR interval ending in a "dropped beat." Type II (Mobitz) AV block is owing to abnormal infranodal conduction, and is usually accompanied by bundle branch block. Second-degree AV block with 2:1 conduction can be a difficult problem...
March 2016: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/26751760/wenckebach-second-degree-heart-block-and-the-company-it-keeps
#13
Isaac R Whitman, Nitish Badhwar
No abstract text is available yet for this article.
March 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/26737292/formation-of-second-degree-atrioventricular-blocks-in-the-cardiac-heterogeneous-oscillator-model
#14
Elena Ryzhii, Maxim Ryzhii
We study formation of second-degree atrioventricular blocks (Wenckebach and Mobitz types) with reduction of coupling between nodes in the heterogeneous oscillator model of cardiac conduction system. We demonstrate that maximal possible number of physiological mode lock patterns in both cases appears at a particular value of coupling coefficient. For the type II atrioventricular block total conduction ratio at high sinus rates might be represented by a product of conduction ratios of atrioventricular nodal and infrahisian blocks...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26723506/atrial-tachycardia-with-wenckebach-atrioventricular-conduction-mechanism-what-is-the-origin-of-the-beat-following-the-pause
#15
Vincenzo Carbone, Maria Pia Calabrò, Vincenzo Marafioti, Giuseppe Oreto
No abstract text is available yet for this article.
January 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/26354228/late-complete-atrioventricular-block-after-closure-of-an-atrial-septal-defect-with-a-gore-septal-occluder-gso%C3%A2
#16
Sven Dittrich, Matthias Sigler, Helga Priessmann
Temporary intermittent complete heart block (CHB) occurred the day after interventional closure of an ASD with a 30 mm Gore Septal Occluder (GSO™) in a 2 years and 11-month-old female. CHB disappeared without further treatment and stable sinus rhythm recovered within 3 days. Only short episodes of 2nd degree AV-block (Wenckebach periodicity) at rare intervals were documented in Holter-monitors the following 2 months. Eleven months after device implantation the patient suffered from long lasting episodes of CHB...
April 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/26336508/the-origins-of-electrocardiography-in-poland
#17
Ryszard W Gryglewski
The progress of science and technology in the 19(th) century enabled better understanding of the electrical activity that occurs during a heartbeat. However, it was only the construction and introduction of the galvanometer that cleared the way for appropriate experimental and clinical studies. Marey, Waller, Wenckebach, Einthoven, and Pardee are just examples of the world's pioneers of electrocardiography. Polish researchers, including Cybulski, Eiger, Rzętkowski, Surzycki, and Latkowski, also contributed to the development of this area of study...
June 2015: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/26265275/first-dose-effects-of-fingolimod-pooled-safety-data-from-three-phase-3-studies
#18
RANDOMIZED CONTROLLED TRIAL
John P DiMarco, Paul O'Connor, Jeffrey A Cohen, Anthony T Reder, Lixin Zhang-Auberson, Dejun Tang, William Collins, Ludwig Kappos
Fingolimod treatment initiation is associated with a transient slowing of heart rate and atrioventricular conduction. This report presents first-dose fingolimod effects (0.5mg or 1.25mg) on cardiac parameters using phase 3 FREEDOMS, FREEDOMS II and TRANSFORMS pooled study data (n=3635 patients). Vital signs were recorded hourly for ≥6h; 12-lead electrocardiogram (ECG) was obtained at baseline and at 6h post-dose. Clinical events were graded at the first-dose administrator׳s discretion. At screening, on day 1 and at month 3, 1073 patients underwent 24-h ambulatory electrocardiogram monitoring...
September 2014: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/26264482/bradycardia-sinus-and-av-node-dysfunction
#19
Cara N Pellegrini, Melvin M Scheinman
The surface electrocardiogram (ECG) holds many clues with regard to the etiology of bradycardia and site of atrioventricular (AV) block. Bedside maneuvers may prove helpful in cases of 2:1 AV block or situations where the data is not all concordant. Wenckebach conduction may occur in any region of the heart, and there are nonpathologic mimickers of Mobitz II AV block as well. The surface ECG may aid in the inference of etiology for better than expected or slowed rather than blocked AV conduction. Sinus node dysfunction may present in several forms and often accompanies other conduction system disease...
September 2015: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/26139310/a-stepwise-approach-to-the-induction-of-idiopathic-fascicular-ventricular-tachycardia
#20
Arun Gopi, Sandeep G Nair, Abhijeet Shelke, Daljeet Kaur Saggu, Sachin Yalagudri, Prabhakar Reddy, Calambur Narasimhan
PURPOSE: Noninducibility of the clinical tachycardia is a major limitation while mapping and ablating idiopathic fascicular ventricular tachycardia (FVT). There is very little data on systematic induction protocols in this entity. Our aim was to study the role of systematic induction protocols in patients with clinically documented ventricular tachycardia (VT). METHODS: Programmed electrical stimulation was performed at baseline from high right atrium, right ventricular apex, right ventricular outflow tract and from left ventricle as per the protocol...
October 2015: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
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