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https://www.readbyqxmd.com/read/27910101/early-safety-and-efficacy-of-fingolimod-treatment-in-denmark
#1
A Voldsgaard, N Koch-Henriksen, M Magyari, F Sellebjerg, P S Sørensen, A B Oturai
BACKGROUND: Initiation of fingolimod treatment is associated with a transient decrease of heart rate, and atrioventricular (AV) conduction block may occur. OBJECTIVE: To evaluate the therapeutic effect and safety of fingolimod treatment in MS patients in Denmark with focus on cardiac and pulmonary side effects at treatment onset. MATERIALS & METHODS: We analysed data from the first 496 fingolimod-treated Danish patients, observed for at least 3 months...
January 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27909532/ajmaline-challenge-to-unmask-infrahisian-disease-in-patients-with-recurrent-and-unexplained-syncope-preserved-ejection-fraction-with-or-without-conduction-abnormalities-on-surface-ecg
#2
Francesco Pentimalli, Luca Bacino, Matteo Ghione, Giambattista Siri, Massimo Gazzarata, Paolo Bellotti
Background: Pharmacological challenge with class I antiarrhythmic drug is a recommended diagnostic test in patients with unexplained syncope only in the presence of bundle branch block, when non-invasive tests have failed to make the diagnosis. Its role in patients with minor or no conduction disturbances on 12-leads ECG has not been evaluated yet. It is also not clear which are the values of His-Ventricular interval to be considered diagnostic. We sought to evaluate the role of ajmaline challenge in unmasking the presence of an infrahisian disease in patients with recurrent and unexplained syncope, regardless of the existence of conduction disturbances on surface ECG...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909527/diagnostic-and-management-difficulties-of-complete-atrioventricular-block-in-children-in-marrakech-a-report-of-three-cases-with-a-review-of-the-literature
#3
Mounia Khramaz Md, Salwa Elkarimi, Dounia Benzerroual, Mustapha Elhattaoui, Fahd Aboutofail, Drissi Boumzebra, Rachid Elhaouati
Complete atrioventricular (AV) block is a rare affection in children. It is the consequence of abnormal conduction tissue within a cardiac malformation or it is due to cardiac injury. Yet the etiology of late complete atrioventricular block in child remains mostly unknown. The treatment of children's Complete atrioventricular block is the implantation of a pacemaker with immediate results satisfactory in the absence of associated cardiomyopathy. In this observation we will treat three cases.
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909515/myocardial-biopsy-in-idiopathic%C3%A2-atrial-fibrillation-and-other-arrhythmias-nosological-diagnosis-clinical-and-morphological-parallels-and-treatment
#4
O V Blagova, A V Nedostup, E A Kogan, V A Sulimov, S A Abugov, A G Kupriyanova, V A Zaydenov, A E Donnikov, E V Zaklyazminskaya, E A Okisheva
BACKGROUND: The nosological nature of "idiopathic" arrhythmias and the effect of etiotropic and pathogenetic treatment are often unknown. METHODS AND RESULTS: 19 patients (42.6±11.3 years, 9 women) with atrial fibrillation (n = 16), supraventricular (n = 10) and ventricular (n = 4) premature beats, supraventricular (n = 2) and ventricular tachycardia (n = 1), left bundle branch block (n= 2), AV block (n = 2) without structural heart changes. Viruses were identified (polymerase chain reaction, PCR) along with measurement of anti-heart antibodies (AHA) and endomyocardial biopsy (EMB)...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909513/assessment-of-sinoatrial-node-function-in-patients-with-persistent-and-long-standing-persistent-forms-of-atrial-fibrillation-after-maze-iii-procedure-combined-with-mitral-valve-operation
#5
Kulikov Aleksei A, Bokeria Leo A
RESEARCH OBJECTIVE: Assessment of sinoatrial node function after Maze III procedure combined with a mitral valve operation. METHODS: 100 patients were included in the research with persistent and long-standing persistent forms of atrial fibrillation (AF) and need of operative treatment concerning valve disease. The following preoperative preparation methods were executed to all patients: Electrocardiogram in 12 standard assignments;Two-dimensional echocardiographic with assessment of systolic and diastolic functions of the left ventricle, size of the left atrium and grade of valve disease;Transesophageal echocardiography for exclusion of blood clots in the left atrium and left atrial appendage;Coronary angiography for exclusion of coronary heart disease;Computer tomography for examination of cardiac chambers and anatomic characteristics of pulmonary veins...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909484/lyme-arrhythmia-in-an-avid-golfer-a-diagnostic-challenge-and-a-therapeutic-dilemma
#6
Ujjwal Rastogi, Dr Nidhi Kumars
Lyme disease is a multisystem disorder affecting dermatologic, cardiac, nervous and musculoskeletal systems. Cardiac manifestations occur in about 5% of Lyme infections and stem from the involvement of the cardiac conduction system, resulting in varying degrees of sino-atrioventricular block. Occasionally, Lyme infection may also present with myopericarditis. Unlike isolated conduction node disease, myocardial involvement presents a great diagnostic and therapeutic dilemma for the physician. We report the case of a 68 year-old male cardiologist who presented with new onset exertional dyspnea and palpitations...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27900839/multicenter-midterm-follow-up-results-using-the-gore-septal-occluder-for-atrial-septal-defect-closure-in-pediatric-patients
#7
Jochen Grohmann, Christian Wildberg, Peter Zartner, Tariq Abu-Tair, Gleb Tarusinov, Erwin Kitzmüller, Claudia Schmoor, Brigitte Stiller, Christoph Kampmann
OBJECTIVES: To assess the safety and efficacy of the Gore Septal Occluder (GSO) used for device-closure of significant secundum-type atrial septal defects (ASD II) focusing on pediatric patients. BACKGROUND: The GSO is a patch-like double disc device. Due to its design, it is assumed to be safe, even when implanted in ASDs with deficient retro-aortic rims. METHODS: Multicenter retrospective analysis of consecutive children and adolescents with a GSO in situ for at least 12 months according to a 1- to 4-year midterm follow-up...
November 30, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27855290/transcatheter-leadless-cardiac-pacing-the-new-alternative-solution
#8
Antoine Da Costa, Amandine Axiotis, Cécile Romeyer-Bouchard, Loucif Abdellaoui, Zahi Afif, Jean Baptiste Guichard, Antoine Gerbay, Karl Isaaz
INTRODUCTION: A lack of information about the feasibility and safety of leadless pacemaker (LPMs) exists in a fragile population of patients with limited venous anatomy access or conventional pacemaker (PM) contraindication. Accordingly, the goal of this prospective observational study was to report our experience with this new leadless technology in a subset of patients with contraindication or limited venous access. METHODS AND RESULTS: Between May 2015 and July 2016, 14 patients were consecutively included...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27849189/sleep-related-bradyarrhythmic-events-and-heart-rate-variability-in-apparently-healthy-individuals
#9
Tolga Çimen, Hamza Sunman, Mehmet Erat, Tolga Han Efe, Ahmet Akyel, Murat Bilgin, Sadık Açıkel, Mehmet Doğan, Ekrem Yeter
OBJECTIVE: It is thought that abnormal cardiac impulses of the autonomic nervous system during sleep are responsible for sleep-related bradyarrhythmias. Despite a proposed common etiopathogenesis and having common name of "sleep-related bradyarrhythmias," precise importance of sinoatrial or atrioventricular (AV) node involvement remains elusive. This study aimed to determine whether there is a difference in sleeprelated bradyarrhythmias from the point of view of heart rate variability (HRV)...
November 10, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27847970/interventional-vsd-closure-with-the-nit-occlud-%C3%A2-l%C3%A3%C2%AA-vsd-coil-in-110-patients-early-and-midterm-results-of-the-eureveco-registry
#10
Nikolaus A Haas, Laura Kock, Harald Bertram, Regina Boekenkamp, Daniel De Wolf, Igor Ditkivskyy, Matthias W Freund, Marc Gewillig, Christoph M Happel, Ulrike Herberg, Edvard Karthasyan, Rainer Kozlik-Feldmann, Oliver Kretschmar, Yulia Kuzmenko, Ornella Milanesi, Goetz Mueller, Giacomo Pongiglione, Stephan Schubert, Gleb Tarusinov, Christoph Kampmann
In August 2010, the Nit-Occlud(®) Lê (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud(®) Lê-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 European centers. In 102 of 111 patients (female 66), successful VSD closure was performed (mean age 8.2 years, mean weight 28.82 kg), 81 perimembranous VSDs (48 with aneurysm), 30 muscular VSDs, mean procedure time was 121...
November 15, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27846458/predictive-factor-and-clinical-consequence-of-left-bundle-branch-block-after-a-transcatheter-aortic-valve-implantation
#11
Takahiko Nishiyama, Sho Tanosaki, Makoto Tanaka, Ryo Yanagisawa, Fumiaki Yashima, Takehiro Kimura, Takahide Arai, Hikaru Tsuruta, Mitsushige Murata, Yoshiyasu Aizawa, Takashi Kohno, Yuichiro Maekawa, Kentaro Hayashida, Seiji Takatsuki, Keiichi Fukuda
BACKGROUND: Atrioventricular conduction disturbances can develop after transcatherter aortic valve implantations (TAVIs) with balloon-expandable valves because the conduction system exists adjacent to the aortic valve. However, the clinical consequence of patients with new onset conduction disturbances is not clear. OBJECTIVE: This study aimed to assess the incidence and progress of new-onset conduction disturbances following TAVIs and the cardiac function evaluated by echocardiography...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27844192/-right-bundle-branch-block-during-right-ventricular-pacing
#12
Harilaos Bogossian, Fuad Hasan, Gerrit Frommeyer, Bernd Lemke, Markus Zarse
INTRODUCTION: We describe the case of a 78-year-old patient who presented for ablation of a wide complex tachycardia with right bundle branch block (RBBB) morphology. A pacemaker spike at the QRS onset indicated supraventricular tachycardia with AV synchronous ventricular pacemaker activation. METHODS: Correct positioning of the ventricular lead in the right ventricular apex was confirmed by fluoroscopy and echocardiography, excluding malpositioning of the right ventricular lead...
November 14, 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27836297/impact-of-early-initiation-of-corticosteroid-therapy-on-cardiac-function-and-rhythm-in-patients-with-cardiac-sarcoidosis
#13
Santosh K Padala, Samuel Peaslee, Mandeep S Sidhu, David A Steckman, Marc A Judson
BACKGROUND: There is limited data on the effect of corticosteroid therapy in patients with cardiac sarcoidosis (CS). We sought to examine the impact of early initiation of corticosteroid therapy, within a month of CS diagnosis, on left ventricular ejection fraction (LVEF), ventricular arrhythmias (VAs), and atrioventricular (AV) block. METHODS: We retrospectively identified 30 CS patients from a large university sarcoidosis clinic. The effect of early initiation of corticosteroid therapy on LVEF was assessed by serial echocardiography, and on VAs and AV block was assessed by Holter monitoring and/or device interrogations...
November 2, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27826129/genotypic-and-phenotypic-predictors-of-complete-heart-block-and-recovery-of-conduction-following-surgical-repair-of-congenital-heart-disease
#14
Laura Murray, Andrew H Smith, English C Flack, Kim Crum, Jill Owen, Prince J Kannankeril
BACKGROUND: Complete heart block (CHB) is a major complication after congenital heart surgery. We hypothesized that genetic and clinical factors are associated with the development of postoperative CHB and recovery of atrioventricular (AV) conduction. OBJECTIVE: To identify predictors of CHB and recovery following congenital heart surgery. METHODS: Patients undergoing congenital heart surgery at our institution from September 2007 through June 2015 were prospectively enrolled in a parent study of postoperative arrhythmias...
November 5, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27815266/role-for-galectin-3-in-calcific-aortic-valve-stenosis
#15
J Rafael Sádaba, Ernesto Martínez-Martínez, Vanessa Arrieta, Virginia Álvarez, Amaya Fernández-Celis, Jaime Ibarrola, Amaia Melero, Patrick Rossignol, Victoria Cachofeiro, Natalia López-Andrés
BACKGROUND: Aortic stenosis (AS) is a chronic inflammatory disease, and calcification plays an important role in the progression of the disease. Galectin-3 (Gal-3) is a proinflammatory molecule involved in vascular osteogenesis in atherosclerosis. Therefore, we hypothesized that Gal-3 could mediate valve calcification in AS. METHODS AND RESULTS: Blood samples and aortic valves (AVs) from 77 patients undergoing AV replacement were analyzed. As controls, noncalcified human AVs were obtained at autopsy (n=11)...
November 4, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27815173/stable-gastric-pentadecapeptide-bpc-157-and-bupivacaine
#16
Gordana Zivanovic-Posilovic, Diana Balenovic, Ivan Barisic, Dean Strinic, Vasilije Stambolija, Mario Udovicic, Sandra Uzun, Domagoj Drmic, Josipa Vlainic, Martina Lovric Bencic, Aleksandra Sindic, Sven Seiwerth, Predrag Sikiric
Bupivacaine toxicity following accidental overdose still lacks therapeutic solution. However, there are major arguments for testing BPC 157 against bupivacaine toxicity in vivo in rats, in particular, and then finally, in vitro. These are: the lack of any known BPC 157 toxicity, a lifesaving effect via the mitigation of arrhythmias in rats underwent hyperkalemia or digitalis toxicity, the elimination of hyperkalemia and arrhythmias in rats underwent succinylcholine toxicity and finally, the reduction of potassium-induced depolarization in vitro (in HEK293 cells) in severe hyperkalemia...
December 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27805004/mir-19b-regulates-ventricular-action-potential-duration-in-zebrafish
#17
Alexander Benz, Mandy Kossack, Dominik Auth, Claudia Seyler, Edgar Zitron, Lonny Juergensen, Hugo A Katus, David Hassel
Sudden cardiac death due to ventricular arrhythmias often caused by action potential duration (APD) prolongation is a common mode of death in heart failure (HF). microRNAs, noncoding RNAs that fine tune gene expression, are frequently dysregulated during HF, suggesting a potential involvement in the electrical remodeling process accompanying HF progression. Here, we identified miR-19b as an important regulator of heart function. Zebrafish lacking miR-19b developed severe bradycardia and reduced cardiac contractility...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27789001/trade-off-between-elimination-of-premature-ventricular-complexes-and-loss-of-synchronized-left-ventricular-pacing-improved-cardiac-function-in-a-patient-with-heart-failure
#18
Hideyuki Hasebe, Masataka Iida, Naoki Hatano, Toshiro Muramatsu
Synchronized left ventricular pacing (sLVP) via adaptive cardiac resynchronization therapy (aCRT) algorithm might enhance the efficacy of CRT. A 71-year-old female was admitted with the diagnosis of heart failure. Electrocardiograms revealed left bundle branch block with QRS width of 144 ms, and frequent premature ventricular complexes (PVCs). A CRT device was implanted, and sLVP via a CRT algorithm was provided. Frequent PVCs arising from the His-bundle suppressed effective sLVP percentage. Radiofrequency application at the His-bundle successfully eliminated the PVCs, but induced complete atrioventricular (AV) block, leading to loss of sLVP...
May 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/27784284/case-report-severe-bradycardia-a-reversible-cause-of-cardio-renal-cerebral-syndrome
#19
Mabel Aoun, Randa Tabbah
BACKGROUND: Cardio-Renal Syndromes were first classified in 2008 and divided into five subtypes. The type 1 Cardio-Renal Syndrome (CRS) is characterized by acute decompensation of heart failure leading to acute kidney injury (AKI). Bradyarrhythmia was not mentioned in the classification as a cause for low cardiac output (CO) in type 1 CRS. Besides, CRS was not previously associated with central nervous system (CNS) injury despite the fact that cardiac, renal and neurological diseases can coexist...
October 26, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27766308/cardiac-disease-and-arrhythmogenesis-mechanistic-insights-from-mouse-models
#20
Lois Choy, Jie Ming Yeo, Vivian Tse, Shing Po Chan, Gary Tse
The mouse is the second mammalian species, after the human, in which substantial amount of the genomic information has been analyzed. With advances in transgenic technology, mutagenesis is now much easier to carry out in mice. Consequently, an increasing number of transgenic mouse systems have been generated for the study of cardiac arrhythmias in ion channelopathies and cardiomyopathies. Mouse hearts are also amenable to physical manipulation such as coronary artery ligation and transverse aortic constriction to induce heart failure, radiofrequency ablation of the AV node to model complete AV block and even implantation of a miniature pacemaker to induce cardiac dyssynchrony...
September 2016: IJC Heart & Vasculature
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