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erythrocyte deformability

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https://www.readbyqxmd.com/read/29686511/effects-of-scrambling-trumpet-creeper-flavone-on-transient-cerebral-ischemia-model-tia-in-rats
#1
Mingsan Miao, Xu Zhang, Fan Zhang, Can Wang, Xiaoyan Fang, Ming Bai, Cuishan Xu, Leshang Teng
To investigate the effects of Scrambling Trumpet Creeper flavone on neurological function score, brain tissue lesion and related biochemical indexes in rat TIA model. Methods: TIA model was induced by tail vein injection of t-butanol (t-BHP). The rats in each administration group were given large, medium and low dose of Scrambling Trumpet Creeper flavone 0.1% CMC suspension, nimodipine and Yangxueqingnao particles group 0.1% CMC suspension, model group and blank group fed the same volume 0.1% CMC. Once a day, continuous administration of 7d...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29682337/erythrocyte-membrane-failure-by-electromechanical-stress
#2
E Du, Yuhao Qiang, Jia Liu
We envision that electrodeformation of biological cells through dielectrophoresis as a new technique to elucidate the mechanistic details underlying membrane failure by electrical and mechanical stresses. Here we demonstrate the full control of cellular uniaxial deformation and tensile recovery in biological cells via amplitude-modified electric field at radio frequency by an interdigitated electrode array in microfluidics. Transient creep and cyclic experiments were performed on individually tracked human erythrocytes...
2018: Applied Sciences
https://www.readbyqxmd.com/read/29676178/afm-as-a-tool-to-evaluate-the-risk-for-cardiovascular-diseases-in-patients
#3
Ana Filipa Guedes, Luís Sargento, José Braz-Nogueira, Nuno Lousada, Carlos Moreira, Filomena A Carvalho, Nuno C Santos
Erythrocyte aggregation is an indicator of cardiovascular risk, which is influenced by plasma fibrinogen concentration. Fibrinogen levels are elevated during cardiovascular diseases. Our main goals were to understand how fibrinogen-erythrocyte binding influences erythrocyte aggregation and how it constitutes a cardiovascular risk factor in essential arterial hypertension (EAH) and chronic heart failure (CHF). Fibrinogen-erythrocyte and erythrocyte-erythrocyte adhesion measurements were conducted by atomic force microscopy (AFM)-based force spectroscopy...
2018: Annals of Medicine
https://www.readbyqxmd.com/read/29660915/hemorheological-and-metabolic-consequences-of-renal-ischemia-reperfusion-and-their-modulation-by-n-n-dimethyl-tryptamine-on-a-rat-model
#4
Katalin Peto, Norbert Nemeth, Anita Mester, Zsuzsanna Magyar, Souleiman Ghanem, Viktoria Somogyi, Bence Tanczos, Adam Deak, Laszlo Bidiga, Ede Frecska, Balazs Nemes
BACKGROUND: Micro-rheological relations of renal ischemia-reperfusion (I/R) have not been completely elucidated yet. Concerning anti-inflammatory agents, it is supposed that sigma-1 receptor agonist N,N-dimethyl-tryptamin (DMT) can be useful to reduce I/R injury. OBJECTIVE: To investigate the micro-rheological and metabolic parameters, and the effects of DMT in renal I/R in rats. METHODS: In anesthetized rats from median laparotomy both kidneys were exposed...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29620655/clinical-characteristics-and-treatment-outcomes-in-camurati-engelmann-disease-a-case-series
#5
Yoon-Myung Kim, Eungu Kang, Jin-Ho Choi, Gu-Hwan Kim, Han-Wook Yoo, Beom Hee Lee
BACKGROUND: Camurati-Engelmann disease is an extremely rare disease characterized by hyperostosis of multiple long bones. This condition is caused by heterozygous mutations in the TGFB1 gene. METHODS: We describe the clinical and genetic characteristics of 4 Korean patients with this rare disease diagnosed at Asan Medical Center in Korea between June 2012 and May 2016, to increase awareness about this condition among general physicians and orthopedists. The presenting features, biochemical findings, radiographic and nuclear imaging findings, molecular analysis, and treatment outcomes of 4 patients were reviewed retrospectively...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29607838/estimation-of-malondialdehyde-levels-in-serum-and-saliva-of-children-affected-with-sickle-cell-anemia
#6
Sudhindra Baliga, Minal Chaudhary, Sham Bhat, Pooja Bhansali, Akshat Agrawal, Satwik Gundawar
Background: Sickle cell anemia (SCA) is an inherited disorder of hemoglobin synthesis characterized by deformed erythrocytes. Hemoglobin S present in sickle-shaped erythrocytes exhibits an enhanced rate of auto-oxidation compared with normal hemoglobin A. It produces more of reactive oxygen species (ROS) which promotes oxidatively stressed environment. ROS degrade the membranes of sickle cell erythrocytes composed of polyunsaturated lipids and form malondialdehyde (MDA) as a by-product...
January 2018: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/29605037/age-and-gender-related-hemorheological-alterations-in-intestinal-ischemia-reperfusion-in-the-rat
#7
Anita Mester, Zsuzsanna Magyar, Akos Molnar, Viktoria Somogyi, Bence Tanczos, Katalin Peto, Norbert Nemeth
BACKGROUND: Intestinal ischemia-reperfusion (I/R) is a life-threatening clinical disorder. During I/R, the microrheological parameters of blood (red blood cell deformability and aggregation) worsen, which may contribute to microcirculatory deterioration. Age and gender also have a great influence on hemorheological parameters. We aimed to investigate the gender and age-related microrheological alterations during intestinal I/R. MATERIALS AND METHODS: After the cannulation of the left femoral artery, median laparotomy was performed in Crl:WI rats under general anesthesia...
May 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29590601/do-skeletal-dynamics-mediate-sugar-uptake-and-transport-in-human-erythrocytes
#8
Robert J Asaro, Qiang Zhu, Pedro Cabrales, Anthony Carruthers
We explore, herein, the hypothesis that transport of molecules or ions into erythrocytes may be affected and directly stimulated by the dynamics of the spectrin/actin skeleton. Skeleton/actin motions are driven by thermal fluctuations that may be influenced by ATP hydrolysis as well as by structural alterations of the junctional complexes that connect the skeleton to the cell's lipid membrane. Specifically, we focus on the uptake of glucose into erythrocytes via glucose transporter 1 and on the kinetics of glucose disassociation at the endofacial side of glucose transporter 1...
March 27, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29578460/recovery-time-course-of-erythrocyte-deformability-following-exposure-to-shear-is-dependent-upon-conditioning-shear-stress
#9
Lennart Kuck, Marijke Grau, Michael J Simmonds
BACKGROUND: Red blood cell (RBC) deformability may increase, or decrease, following application of shear stress ("shear conditioning"), depending upon the specific magnitude and duration of exposure. However, the time course of altered RBC deformability following shear remains unresolved. OBJECTIVE: We utilised shear conditioning known to increase (10 Pa) or decrease (64 Pa) RBC deformability and subsequently rested the cells; serial measurements of deformability during the rest period facilitated defining the time course of recoverability...
March 21, 2018: Biorheology
https://www.readbyqxmd.com/read/29562483/effects-of-aging-and-gender-on-micro-rheology-of-blood-in-3-to-18-months-old-male-and-female-wistar-crl-wi-rats
#10
Viktoria Somogyi, Katalin Peto, Adam Deak, Bence Tanczos, Norbert Nemeth
BACKGROUND: Age- and gender-related alterations of hemorheological parameters have not been completely elucidated to date. Experiments on older animals may give valuable information on this issue. However, the majority of rheological studies have been performed in young rodents. OBJECTIVE: We aimed to investigate the influence of aging and gender on hemorheological parameters in rats. METHODS: Coeval male (n=10) and female (n=10) Wistar (Crl:WI) rats were followed-up over 15 months...
March 12, 2018: Biorheology
https://www.readbyqxmd.com/read/29536743/investigation-of-the-effects-of-thymoquinone-on-erythrocyte-deformability-in-sepsis-treatment-which-created-by-cecal-perforation-in-rat
#11
H Bostanci, K Dikmen, F M Comu, M Arslan, A Kucuk
AIM: We aimed to study the effects of thymoquinone on erythrocyte deformability in an experimental model of sepsis given before or after the initiation of the sepsis model. METHOD: The animals were grouped as (n = 6) control, nigella sativa, sepsis, sepsis group with administration of nigella sativa before sepsis development and sepsis group with nigella sativa administration after sepsis development. Cecal ligation and puncture model (CLP) was used to induce sepsis in the animals...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29479982/protective-effect-of-erdosteine-on-erythrocyte-deformability-in-a-rat-model-of-lower-limb-ischemia-reperfusion-injury
#12
Abdullah Özer, Hüseyin Demirtaş, Faruk Metin Çomu, Dilek Erer, Yiğit Kılıç, Barış Mardin, Ayşegül Küçük, G. Levent Oktar
Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteine on erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized control group (group 'control', n = 6), an ischemia/reperfusion group without erdosteine (group 'ischemia/reperfusion', n = 6), and an ischemia/reperfusion group with erdosteine at 150 mg kg−1, intraperitoneally (group 'ischemia/reperfusion - erdosteine', n = 6)...
February 23, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29453921/changes-in-erythrocyte-deformability-during-day-and-possible-role-of-melatonin
#13
Rastislav Vazan, Katarina Plauterova, Gabriela Porubska, Jana Radosinska
OBJECTIVES: The deformability of erythrocytes is their ability to change shape in order to pass through the capillaries. Th is is necessary for quality of microcirculation and sufficient delivery of oxygen to the tissues. Th e aim of our study was to investigate the possible spontaneous changes in the erythrocyte deformability during day and evaluation of the possible direct effects of melatonin (hormone involved in regulation of biorhythms) on the erythrocyte deformability. METHODS: Samples of capillary blood were taken from 12 healthy volunteers in the morning (8:00) and early in the evening (16:30)...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29442482/a-study-on-the-relationship-between-plasma-selenium-concentration-and-erythrocyte-deformability-in-rat-models-of-coronary-heart-disease
#14
Changjiang Zhang, Yinzhi Deng, Yuhua Lei, Jingbo Zhao, Wen Wei, Yuanhong Li
No abstract text is available yet for this article.
February 13, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29423718/disease-severity-impacts-the-relationship-of-apelin-with-arterial-function-in-patients-with-rheumatoid-arthritis
#15
Sulé Gunter, Chanel Robinson, Gavin R Norton, Angela J Woodiwiss, Linda Tsang, Aletta M E Millen, Patrick H Dessein
Apelin can improve arterial function by enhancing the expression of endothelial nitric oxide synthase but this effect depends markedly on endothelial integrity. We hypothesized that inflammation influences the potential impact of apelin on arterial function in rheumatoid arthritis (RA). We assessed the associations of apelin concentrations with arterial stiffness (pulse wave velocity), wave reflection (augmentation index, reflected wave pressure, and reflection magnitude), and pressure pulsatility (central systolic pressure (CSP), central pulse pressure (CPP), peripheral pulse pressure (PPP), pulse pressure amplification (PPamp), and forward wave pressure (Pf)) among 170 RA patients without cardiovascular disease...
February 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29374477/epoetin-beta-pegol-for-treatment-of-anemia-ameliorates-deterioration-of-erythrocyte-quality-associated-with-chronic-kidney-disease
#16
Ken Aizawa, Ryohei Kawasaki, Yoshihito Tashiro, Yasushi Shimonaka, Michinori Hirata
BACKGROUND: Epoetin beta pegol (continuous erythropoietin receptor activator; C.E.R.A.) is currently widely used for the treatment of anemia associated with chronic kidney disease (CKD). Therapeutic control of anemia is assessed by monitoring haemoglobin (Hb) levels. However, certain qualitative aspects of erythrocytes are also impaired in CKD, including loss of deformability and shortened life-span. Therefore, monitoring Hb alone could potentially fail to reveal pathological changes in erythrocytes...
January 27, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29365311/biocompatible-coupling-of-therapeutic-fusion-proteins-to-human-erythrocytes
#17
Carlos H Villa, Daniel C Pan, Ian H Johnston, Colin F Greineder, Landis R Walsh, Elizabeth D Hood, Douglas B Cines, Mortimer Poncz, Don L Siegel, Vladimir R Muzykantov
Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuman-primate single-chain antibody fragments (scFvs) directed to human RBCs and fused scFvs with human thrombomodulin (hTM) as a representative biotherapeutic cargo (hTM-scFv). Binding fusions to RBCs on band 3/glycophorin A (GPA; Wright b [Wrb ] epitope) and RhCE (Rh17/Hr0 epitope) similarly endowed RBCs with hTM activity, but differed in their effects on RBC physiology...
February 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29364234/measuring-deformability-and-red-cell-heterogeneity-in-blood-by-ektacytometry
#18
Nermi L Parrow, Pierre-Christian Violet, Hongbin Tu, James Nichols, Corinne A Pittman, Courtney Fitzhugh, Robert E Fleming, Narla Mohandas, John F Tisdale, Mark Levine
Decreased red cell deformability is characteristic of several disorders. In some cases, the extent of defective deformability can predict severity of disease or occurrence of serious complications. Ektacytometry uses laser diffraction viscometry to measure the deformability of red blood cells subject to either increasing shear stress or an osmotic gradient at a constant value of applied shear stress. However, direct deformability measurements are difficult to interpret when measuring heterogenous blood that is characterized by the presence of both rigid and deformable red cells...
January 12, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29358701/insights-into-cerebral-haemodynamics-and-oxygenation-utilising-in-vivo-mural-cell-imaging-and-mathematical-modelling
#19
Paul W Sweeney, Simon Walker-Samuel, Rebecca J Shipley
The neurovascular mechanisms underpinning the local regulation of cerebral blood flow (CBF) and oxygen transport remain elusive. In this study we have combined novel in vivo imaging of cortical microvascular and mural cell architecture with mathematical modelling of blood flow and oxygen transport, to provide new insights into CBF regulation that would be inaccessible in a conventional experimental context. Our study indicates that vasoconstriction of smooth muscle actin-covered vessels, rather than pericyte-covered capillaries, induces stable reductions in downstream intravascular capillary and tissue oxygenation...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29332028/possible-erythrocyte-contributions-to-and-exacerbation-of-the-post-thrombolytic-no-reflow-phenomenon
#20
Shang-Jen Yu, James P Buerck, Edgar A O'Rear, Thomas L Whitsett
BACKGROUND: Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation. OBJECTIVE: To assess possible red cell contributions to post-thrombolytic no-reflow phenomenon. METHODS: Blood clots were formed by recalcifying 1 ml of citrated fresh human venous blood and then lysed by adding 1,000 units of streptokinase (SK) at several intervals within 1 hour...
2018: Biorheology
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