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erythrocyte deformability

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https://www.readbyqxmd.com/read/29442482/a-study-on-the-relationship-between-plasma-selenium-concentration-and-erythrocyte-deformability-in-rat-models-of-coronary-heart-disease
#1
Changjiang Zhang, Yinzhi Deng, Yuhua Lei, Jingbo Zhao, Wen Wei, Yuanhong Li
No abstract text is available yet for this article.
February 13, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29423718/disease-severity-impacts-the-relationship-of-apelin-with-arterial-function-in-patients-with-rheumatoid-arthritis
#2
Sulé Gunter, Chanel Robinson, Gavin R Norton, Angela J Woodiwiss, Linda Tsang, Aletta M E Millen, Patrick H Dessein
Apelin can improve arterial function by enhancing the expression of endothelial nitric oxide synthase but this effect depends markedly on endothelial integrity. We hypothesized that inflammation influences the potential impact of apelin on arterial function in rheumatoid arthritis (RA). We assessed the associations of apelin concentrations with arterial stiffness (pulse wave velocity), wave reflection (augmentation index, reflected wave pressure, and reflection magnitude), and pressure pulsatility (central systolic pressure (CSP), central pulse pressure (CPP), peripheral pulse pressure (PPP), pulse pressure amplification (PPamp), and forward wave pressure (Pf)) among 170 RA patients without cardiovascular disease...
February 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29374477/epoetin-beta-pegol-for-treatment-of-anemia-ameliorates-deterioration-of-erythrocyte-quality-associated-with-chronic-kidney-disease
#3
Ken Aizawa, Ryohei Kawasaki, Yoshihito Tashiro, Yasushi Shimonaka, Michinori Hirata
BACKGROUND: Epoetin beta pegol (continuous erythropoietin receptor activator; C.E.R.A.) is currently widely used for the treatment of anemia associated with chronic kidney disease (CKD). Therapeutic control of anemia is assessed by monitoring haemoglobin (Hb) levels. However, certain qualitative aspects of erythrocytes are also impaired in CKD, including loss of deformability and shortened life-span. Therefore, monitoring Hb alone could potentially fail to reveal pathological changes in erythrocytes...
January 27, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29365311/biocompatible-coupling-of-therapeutic-fusion-proteins-to-human-erythrocytes
#4
Carlos H Villa, Daniel C Pan, Ian H Johnston, Colin F Greineder, Landis R Walsh, Elizabeth D Hood, Douglas B Cines, Mortimer Poncz, Don L Siegel, Vladimir R Muzykantov
Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuman-primate single-chain antibody fragments (scFvs) directed to human RBCs and fused scFvs with human thrombomodulin (hTM) as a representative biotherapeutic cargo (hTM-scFv). Binding fusions to RBCs on band 3/glycophorin A (GPA; Wright b [Wrb] epitope) and RhCE (Rh17/Hr0 epitope) similarly endowed RBCs with hTM activity, but differed in their effects on RBC physiology...
February 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29364234/measuring-deformability-and-red-cell-heterogeneity-in-blood-by-ektacytometry
#5
Nermi L Parrow, Pierre-Christian Violet, Hongbin Tu, James Nichols, Corinne A Pittman, Courtney Fitzhugh, Robert E Fleming, Narla Mohandas, John F Tisdale, Mark Levine
Decreased red cell deformability is characteristic of several disorders. In some cases, the extent of defective deformability can predict severity of disease or occurrence of serious complications. Ektacytometry uses laser diffraction viscometry to measure the deformability of red blood cells subject to either increasing shear stress or an osmotic gradient at a constant value of applied shear stress. However, direct deformability measurements are difficult to interpret when measuring heterogenous blood that is characterized by the presence of both rigid and deformable red cells...
January 12, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29358701/insights-into-cerebral-haemodynamics-and-oxygenation-utilising-in-vivo-mural-cell-imaging-and-mathematical-modelling
#6
Paul W Sweeney, Simon Walker-Samuel, Rebecca J Shipley
The neurovascular mechanisms underpinning the local regulation of cerebral blood flow (CBF) and oxygen transport remain elusive. In this study we have combined novel in vivo imaging of cortical microvascular and mural cell architecture with mathematical modelling of blood flow and oxygen transport, to provide new insights into CBF regulation that would be inaccessible in a conventional experimental context. Our study indicates that vasoconstriction of smooth muscle actin-covered vessels, rather than pericyte-covered capillaries, induces stable reductions in downstream intravascular capillary and tissue oxygenation...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29332028/possible-erythrocyte-contributions-to-and-exacerbation-of-the-post-thrombolytic-no-reflow-phenomenon
#7
Shang-Jen Yu, James P Buerck, Edgar A O'Rear, Thomas L Whitsett
BACKGROUND: Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation. OBJECTIVE: To assess possible red cell contributions to post thrombolytic no-reflow phenomenon. METHODS: Blood clots were formed by recalcifying 1 ml of citrated fresh human venous blood and then lysed by adding 1,000 units of streptokinase (SK) at several intervals within 1 hour...
January 11, 2018: Biorheology
https://www.readbyqxmd.com/read/29316749/-effects-of-baicalin-on-the-changes-in-hemorheology-of-acute-respiratory-distress-syndrome-in-rats
#8
Z M Zhao, Y M Zheng, Y L Zhang, S Q Li
Objective: To investigate the effect of baicalin on the changes in hemorheology and its mechanism during the development of Acute Respiratory Distress Syndrome(ARDS) induced by oleic acid (OA) in rats. Methods: Rats were randomized into 3 groups: control, ARDS (OA induction, 0.12 mg/kg) and ba-icalin-treated group (300 mg/kg). The blood samples were collected at 30 min, 1, 2, 3, 6, 12 and 6 h after OA injection. The whole blood viscosity, plasma viscosity, Maximum erythrocyte deformability index (DImax) were detected...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29309044/differentiation-of-neutrophil-like-hl-60-cells-strongly-impacts-their-rolling-on-surfaces-with-various-adhesive-properties-under-a-pressing-force
#9
Atsushi Shirai, Yoshiro Sugiyama, Jean-Paul Rieu
BACKGROUND: HL-60 cells have been used in in vitro experiments of neutrophils rolling. They lose uniform spherical appearance and enhance deformability by differentiation to neutrophil-like cells, which would affect their rolling characteristics. OBJECTIVE: We investigate the influence of differentiation and coating of target substrate on the fundamental rolling characteristics of the cells under a constant pressing force which mimics the pressing force to the vessel wall by erythrocytes in vivo...
December 29, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29306823/sensitivity-of-medaka-oryzias-latipes-to-4-nonylphenol-subacute-exposure-erythrocyte-alterations-and-apoptosis
#10
Alaa El-Din H Sayed, Chisato Kataoka, Shoji Oda, Shosaku Kashiwada, Hiroshi Mitani
The present study was undertaken to assess the effects of the endocrine-disrupting compound; 4-nonylphenol (4-NP) in medaka (Oryzias latipes). The frequencies of erythrocyte alterations, apoptosis, and micronuclei were used as biological indicators of damage. Medaka were exposed 15 days to 4-NP at three sublethal concentrations (50, 80, and 100 μg/l 4-NP) and results compared with those of a previous study using catfish as an animal model. Exposure of medaka resulted in a dose-dependent increase in the frequency of erythrocyte alterations, apoptosis and micronucleus (MN)...
December 26, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29275179/haemato-protective-influence-of-dietary-fenugreek-trigonella-foenum-graecum-l-seeds-is-potentiated-by-onion-allium-cepa-l-in-streptozotocin-induced-diabetic-rats
#11
Seetur R Pradeep, Krishnapura Srinivasan
We have recently reported the beneficial modulation of metabolic abnormalities and oxidative stress in diabetic rats by dietary fenugreek seeds and onion. This investigation evaluated the protective influence of dietary fenugreek seeds (100 g kg-1) and onion (30 g kg-1) on erythrocytes of streptozotocin-induced diabetic rats, through modulation of reduced haematological indices and antisickling potency. This study also evaluated the altered erythrocyte membrane lipid profile and beneficial countering of increased lipid peroxidation, osmotic fragility, along with reduced membrane fluidity and deformability, nitric oxide production and echinocyte formation...
December 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29238303/near-wall-migration-dynamics-of-erythrocytes-in-vivo-effects-of-cell-deformability-and-arteriolar-bifurcation
#12
Bumseok Namgung, Yan Cheng Ng, Hwa Liang Leo, Joseph M Rifkind, Sangho Kim
Red blood cell (RBC) deformability has a significant impact on microcirculation by affecting cell dynamics. Despite previous studies that have demonstrated the margination of rigid cells and particles in vitro, little information is available on the in vivo margination of deformability-impaired RBCs under physiological flow and hematocrit conditions. Thus, in this study, we examined how the deformability-dependent, RBC migration alters the cell distribution under physiological conditions, particularly in arteriolar network flows...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29215846/-possibilities-of-correction-rheological-blood-svoytv-at-chipped-and-cut-wounds-of-the-breast
#13
V V Masljakov, O A Suhanova, V G Barsukov, K G Kurkin, S A Suhanov
The purpose: research objective: to study influence of electromagnetic oscillations of millimetric range on rheological properties of blood at patients with chipped and cut wounds of a breast for the purpose of their correction. Methods. For the solution of a research objective we have carried out studying of changes of rheological properties of blood at the 22nd patient with the getting chipped and cut wounds of a breast without internal injury during the next postoperative period. All patient has executed primary surgical processing and drainage of a pleural cavity...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29185111/factors-influencing-spinal-sagittal-balance-bone-mineral-density-and-oswestry-disability-index-outcome-measures-in-patients-with-rheumatoid-arthritis
#14
Kazutaka Masamoto, Bungo Otsuki, Shunsuke Fujibayashi, Koichiro Shima, Hiromu Ito, Moritoshi Furu, Motomu Hashimoto, Masao Tanaka, Stephen Lyman, Hiroyuki Yoshitomi, Shimei Tanida, Tsuneyo Mimori, Shuichi Matsuda
PURPOSE: To identify the factors influencing spinal sagittal alignment, bone mineral density (BMD), and Oswestry Disability Index (ODI) outcome measures in patients with rheumatoid arthritis (RA). METHODS: We enrolled 272 RA patients to identify the factors influencing sagittal vertical axis (SVA). Out of this, 220 had evaluation of bone mineral density (BMD) and vertebral deformity (VD) on the sagittal plane; 183 completed the ODI questionnaire. We collected data regarding RA-associated clinical parameters and standing lateral X-ray images via an ODI questionnaire from April to December 2012 at a single center...
November 28, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29175339/molecular-mechanisms-of-deformability-of-plasmodium-infected-erythrocytes
#15
REVIEW
Catherine Lavazec
In physiological conditions, normal erythrocytes are highly deformable due to their high surface area to volume ratio, their moderate cytoplasmic viscosity and the elasticity of their membrane skeleton. Infection with the human malaria parasite Plasmodium falciparum induces dramatic changes in cellular deformability and membrane elasticity of their host erythrocyte, in part due to the shape and the volume of the parasite itself, and to the export of parasite proteins that interact with host membrane skeletal proteins...
November 22, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29145008/morphological-changes-in-erythrocytes-of-people-with-type-2-diabetes-mellitus-evaluated-with-atomic-force-microscopy-a-brief-review
#16
REVIEW
Alejandra Loyola-Leyva, Juan Pablo Loyola-Rodríguez, Marco Atzori, Francisco Javier González
Prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Cardiovascular diseases are one of the main causes of death among people with T2DM. Morphological changes in erythrocytes have been associated with higher risk of cardiovascular diseases. Atomic force microscopy (AFM) is a new technique that allows non-invasive imaging of cells and the evaluation of changes in mechanical properties. AIM: To evaluate by AFM the erythrocytes morphological changes of people with T2DM METHODS: Search was conducted from in PubMed, ScienceDirect, Scielo, and Lilacs...
November 10, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29133350/extracellular-histones-induce-erythrocyte-fragility-and-anemia
#17
Farzaneh Kordbacheh, Connor H O'Meara, Lucy A Coupland, Patrick M Lelliott, Christopher R Parish
Extracellular histones have been shown to play an important pathogenic role in many diseases, primarily through their cytotoxicity towards nucleated cells and their ability to promote platelet activation with resultant thrombosis and thrombocytopenia. In contrast, little is known about the effect of extracellular histones on erythrocyte function. We demonstrate here that histones promote erythrocyte aggregation, sedimentation and, using a novel in vitro shear stress model, induce erythrocyte fragility and lysis in a concentration dependent manner...
November 13, 2017: Blood
https://www.readbyqxmd.com/read/29128605/erythrocytes-as-a-biological-model-for-screening-of-xenobiotics-toxicity
#18
REVIEW
Mayada Ragab Farag, Mahmoud Alagawany
Erythrocytes are the main cells in circulation. They are devoid of internal membrane structures and easy to be isolated and handled providing a good model for different assays. Red blood cells (RBCs) plasma membrane is a multi-component structure that keeps the cell morphology, elasticity, flexibility and deformability. Alteration of membrane structure upon exposure to xenobiotics could induce various cellular abnormalities and releasing of intracellular components. Therefore the morphological changes and extracellular release of haemoglobin [hemolysis] and increased content of extracellular adenosine triphosphate (ATP) [as signs of membrane stability] could be used to evaluate the cytotoxic effects of various molecules...
January 5, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29124118/chemical-analysis-and-evaluation-of-antioxidant-antimicrobial-and-photoprotective-activities-of-schinopsis-brasiliensis-engl-anacardiaceae
#19
Sarah Raquel Gomes de Lima-Saraiva, Fernanda Granja da Silva Oliveira, Raimundo Gonçalves de Oliveira Junior, Camila de Souza Araújo, Ana Paula de Oliveira, Alessandra Gomes Marques Pacheco, Larissa Araújo Rolim, Elba Lúcia Cavalcanti de Amorim, Francine Celise Siqueira César, Jackson Roberto Guedes da Silva Almeida
Schinopsis brasiliensis Engl. is a native plant of Caatinga which has high concentrations of compounds capable of absorbing ultraviolet light, suggesting its potential application for the development of sunscreen preparations. After its identification and collection, this vegetable drug was submitted to a physicochemical analysis through the preparation of ethanolic extract. The phytochemical screening and analysis of extracts were carried out by high-performance liquid chromatography (HPLC) evaluation. The antioxidant activity of the extract was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and β-carotene bleaching test...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/29089816/impaired-hemorheology-in-exacerbations-of-copd
#20
Erhan Ugurlu, Emine Kilic-Toprak, Ilknur Can, Ozgen Kilic-Erkek, Goksel Altinisik, Melek Bor-Kucukatay
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. MATERIALS AND METHODS: The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
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