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Junctional Rhythm

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https://www.readbyqxmd.com/read/28671548/motoneurons-regulate-the-central-pattern-generator-during-drug-induced-locomotor-like-activity-in-the-neonatal-mouse
#1
Melanie Falgairolle, Joshua G Puhl, Avinash Pujala, Wenfang Liu, Michael James O'Donovan
Motoneurons are traditionally viewed as the output of the spinal cord that do not influence locomotor rhythmogenesis. We assessed the role of motoneuron firing during ongoing locomotor-like activity in neonatal mice expressing archaerhopsin-3 (Arch), halorhodopsin (eNpHR), or channelrhodopsin-2 (ChR2) in Choline acetyltransferase expressing neurons (ChAT(+)) or the LIM-homeodomain transcription factor Isl1(+) neurons. Illumination of the lumbar cord in mice expressing eNpHR or Arch in ChAT(+) or Isl1(+) neurons, depressed motoneuron discharge, transiently decreased the frequency, and perturbed the phasing of the locomotor-like rhythm...
July 3, 2017: ELife
https://www.readbyqxmd.com/read/28666343/intraoperative-arrhythmias-in-children-with-congenital-heart-disease-transient-innocent-events
#2
Charlotte A Houck, Tanwier T T K Ramdjan, Ameeta Yaksh, Christophe P Teuwen, Eva A H Lanters, Ad J J C Bogers, Natasja M S de Groot
Aims: The significance and incidences of intraoperative arrhythmias occurring in the operating room (OR) in children with congenital heart disease (CHD) are unknown. Aims of this study were to determine incidences of intraoperative arrhythmias in children with CHD and to examine whether they are associated with persistent arrhythmias during follow-up. Methods and results: Continuous ECG recordings obtained from 134 consecutive paediatric CHD patients were manually examined from the moment the aortic cross-clamp (ACC) was removed [use of ACC and cardiopulmonary bypass (CPB)], when CPB was stopped (use of only CPB) or when the sternum was closed (no use of ACC and CPB) until departure from the OR...
June 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28658116/an-interesting-implantable-cardioverter-defibrillator-treatment-for-lethal-ventricular-arrhythmias-caused-by-coronary-artery-spasm-a-case-report
#3
Jie Sun, Li Feng, Fei Li, Yanchun Zhang, Jianting Dong
RATIONALE: Coronary artery spasm (CAS) could cause serious lethal ventricular arrhythmias. While implantable cardioverter defibrillators (ICDs) have been recommend for secondary prevention of sudden cardiac death related to lethal ventricular arrhythmias. However, in resuscitated sudden cardiac death caused by CAS, the effect of ICD is still not well clear. PATIENT CONCERNS: A 60-year-old male presented with 2 episodes of syncope. Coronary angiography showed normal coronary arteries...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28576728/cellular-circadian-oscillators-in-the-suprachiasmatic-nucleus-remain-coupled-in-the-absence-of-connexin-36
#4
Tanja Diemer, Dominic Landgraf, Takako Noguchi, Haiyun Pan, Jose L Moreno, David K Welsh
In mammals, the master circadian clock resides in the suprachiasmatic nucleus (SCN). The SCN is characterized by robust circadian oscillations of clock gene expression and neuronal firing. The synchronization of circadian oscillations among individual cells in the SCN is attributed to intercellular coupling. Previous studies have shown that gap junctions, specifically those composed of connexin-36 (Cx36) subunits, are required for coupling of electrical firing among SCN neurons at a time scale of milliseconds...
May 31, 2017: Neuroscience
https://www.readbyqxmd.com/read/28503133/behavioral-senescence-and-aging-related-changes-in-motor-neurons-and-brain-neuromodulator-levels-are-ameliorated-by-lifespan-extending-reproductive-dormancy-in-drosophila
#5
Sifang Liao, Susan Broughton, Dick R Nässel
The lifespan of Drosophilamelanogaster can be extended substantially by inducing reproductive dormancy (also known as diapause) by lowered temperature and short days. This increase of longevity is accompanied by lowered metabolism and increased stress tolerance. We ask here whether behavioral senescence is ameliorated during adult dormancy. To study this we kept flies for seven or more weeks in normal rearing conditions or in diapause conditions and compared to 1-week-old flies in different behavioral assays of sleep, negative geotaxis and exploratory walking...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28458438/chronic-lithium-intoxication-varying-electrocardiogram-manifestations
#6
Raja Naga Mahesh Maddala, A J Ashwal, M Sudhakar Rao, R Padmakumar
Lithium is a commonly used drug in psychiatric practice. It is used in the treatment of depression and bipolar disorder. It has a narrow therapeutic index with documented adverse effects even near therapeutic levels. It has myriad of manifestations at toxic levels. The cardiovascular effects range from relatively benign ST-T wave changes to fatal arrhythmias. We describe a case of lithium toxicity which presented as a junctional rhythm and later showed a variety of manifestations such as complete heart block, atrial fibrillation, sinus bradycardia, and finally reverted to sinus rhythm at par with serum lithium levels...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28427082/perioperative-outcomes-and-safety-of-atrial-fibrillation-catheter-ablation-in-octogenarians-a-retrospective-study-and-review-of-the-benefits-of-rhythm-control
#7
Stephanie Hakimian, Juan C Camacho, Edwin Grajeda Silvestri, Farid AbdelMalak, Elie Donath, Robert Chait
OBJECTIVES: Catheter ablation for rhythm control has emerged as a successful therapeutic option for the treatment of atrial fibrillation (AF), though it has not been well studied in octogenarians. This study evaluates its safety in octogenarians in a community hospital and reviews the benefits of rhythm control. METHODS: Among 1,592 patients undergoing AF ablation, 84 octogenarian were identified. The primary outcome was normal sinus rhythm (NSR) on electrocardiogram at discharge...
2017: Cardiology
https://www.readbyqxmd.com/read/28420965/dopamine-a-modulator-of-circadian-rhythms-in-the-central-nervous-system
#8
REVIEW
Kirill S Korshunov, Laura J Blakemore, Paul Q Trombley
Circadian rhythms are daily rhythms that regulate many biological processes - from gene transcription to behavior - and a disruption of these rhythms can lead to a myriad of health risks. Circadian rhythms are entrained by light, and their 24-h oscillation is maintained by a core molecular feedback loop composed of canonical circadian ("clock") genes and proteins. Different modulators help to maintain the proper rhythmicity of these genes and proteins, and one emerging modulator is dopamine. Dopamine has been shown to have circadian-like activities in the retina, olfactory bulb, striatum, midbrain, and hypothalamus, where it regulates, and is regulated by, clock genes in some of these areas...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28416984/the-inferior-displacement-of-the-his-bundle-and-fast-pathway-in-a-patient-with-common-type-atrioventricular-nodal-tachycardia-three-dimensional-computed-tomography-analysis
#9
Kunihiko Kiuchi, Koji Fukuzawa, Mori Shumpei, Tatsuya Nishii
A 66-year-old woman with palpitations was referred to our center for catheter ablation due to drug-refractory, common type atrioventricular nodal tachycardia (AVNRT). A selective slow pathway ablation was attempted. A fast junctional rhythm with transient ventriculoatrial block followed by transient prolongation of the A-H interval occurred immediately after the radiofrequency (RF) application at the coronary sinus ostium (CSOS) level. To assess the location of the fast pathway and His bundle, we sought to visualize the anatomy of the triangle of Koch (TOK) by three-dimensional computed tomography (CT)...
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28374333/how-to-approach-difficult-cases-of-avnrt
#10
REVIEW
Darpan S Kumar, Thomas A Dewland, Seshadri Balaji, Charles A Henrikson
Our approach to the ablation of atrioventricular nodal reciprocating tachycardia (AVNRT), the most common supraventricular tachycardia, is as follows: We first attempt ablation in the right atrial posteroseptum anterior to the coronary sinus ostium with a 4-mm non-irrigated tip catheter. If ablation within the triangle of Koch is unsuccessful with radiofrequency (RF), we switch to cryoablation and target a more superior (mid septal) region. We also utilize cryoablation if RF ablation produces transient VA block (absence of retrograde conduction during junctional rhythm) or a fast junctional rhythm (<350 msec)...
May 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28294644/electrocardiogram-changes-and-atrial-arrhythmias-in-individuals-carrying-sodium-channel-scn5a-d1275n-mutation
#11
Sari U M Vanninen, Kjell Nikus, Katriina Aalto-Setälä
INTRODUCTION: The cardiac sodium channel SCN5A regulates atrioventricular and ventricular depolarization as well as cardiac conduction. Patients with cardiac electrical abnormalities have an increased risk of sudden cardiac death (SCD) and cardio-embolic stroke. Optimal management of cardiac disease includes the understanding of association between the causative mutations and the clinical phenotype. A 12-lead electrocardiogram (ECG) is an easy and inexpensive tool for finding risk patients...
April 17, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28262258/safer-and-escape-junctional-rhythm-a-singular-trigger-for-pacemaker-mediated-tachycardia
#12
Pasquale Crea, Teresa Crea, Giuseppe Picciolo, Francesco Luzza
A 70-year-old man, who previously received a dual chamber pacemaker for paroxysmal AV block (Sorin Symphony DR 2550), was noted on telemetry to have multiple episodes of rapid ventricular pacing at approximately 120bpm. Evaluation of the telemetry strips revealed that all of the rapid ventricular pacing episodes were initiated by brief runs of escape junctional rhythm. Programmed bradycardia parameters were AAI SafeR with lower rate limit of 50bpm.
July 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28261081/asymmetry-factors-shaping-regular-and-irregular-bursting-rhythms-in-central-pattern-generators
#13
Irene Elices, Pablo Varona
Central Pattern Generator (CPG) circuits are neural networks that generate rhythmic motor patterns. These circuits are typically built of half-center oscillator subcircuits with reciprocally inhibitory connections. Another common property in many CPGs is the remarkable rich spiking-bursting dynamics of their constituent cells, which balance robustness and flexibility to generate their joint coordinated rhythms. In this paper, we use conductance-based models and realistic connection topologies inspired by the crustacean pyloric CPG to address the study of asymmetry factors shaping CPG bursting rhythms...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28258363/theta-rhythm-makes-the-world-go-round-dissociative-effects-of-tms-theta-versus-alpha-entrainment-of-right-ptpj-on-embodied-perspective-transformations
#14
Gerard Gooding-Williams, Hongfang Wang, Klaus Kessler
Being able to imagine another person's experience and perspective of the world is a crucial human ability and recent reports suggest that humans "embody" another's viewpoint by mentally rotating their own body representation into the other's orientation. Our recent Magnetoencephalography (MEG) data further confirmed this notion of embodied perspective transformations and pinpointed the right posterior temporo-parietal junction (pTPJ) as the crucial hub in a distributed network oscillating at theta frequency (3-7 Hz)...
March 3, 2017: Brain Topography
https://www.readbyqxmd.com/read/28256386/-reliability-study-on-the-interpretation-of-electrocardiograms-by-general-practitioners-and-trainees
#15
F J Alonso Moreno, R Orueta Sánchez, A Segura Fragoso, A I Rabadán Velasco, L Luna Del Pozo, A Villarín Castro, M Baquero Alonso, L Rodríguez Padial
OBJECTIVE: To determine the reliability of the interpretation of electrocardiograms (ECG) by general practitioners and those in training by making a comparison with the interpretation made by the cardiologist. MATERIAL AND METHODS: An observational study was conducted that included general practitioners working in the Toledo Health Area, physicians during their training in Family and Community Medicine, and cardiologists in their first 3 years of specialist training (R1-R3)...
February 27, 2017: Semergen
https://www.readbyqxmd.com/read/28245529/synchrony-and-so-much-more-diverse-roles-for-electrical-synapses-in-neural-circuits
#16
REVIEW
Barry W Connors
Electrical synapses are neuronal gap junctions that are ubiquitous across brain regions and species. The biophysical properties of most electrical synapses are relatively simple-transcellular channels allow nearly ohmic, bidirectional flow of ionic current. Yet these connections can play remarkably diverse roles in different neural circuit contexts. Recent findings illustrate how electrical synapses may excite or inhibit, synchronize or desynchronize, augment or diminish rhythms, phase-shift, detect coincidences, enhance signals relative to noise, adapt, and interact with nonlinear membrane and transmitter-release mechanisms...
May 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28213312/multiple-myocardial-abscesses-secondary-to-late-stent-infection
#17
Ayman Elbadawi, Marwan Saad, Islam Y Elgendy, Aneeqa Zafar, Ming-Yan Chow
A 53-year-old woman presented to our hospital with dizziness and low-grade fever. She underwent percutaneous coronary intervention to the obtuse marginal artery with a drug-eluting stent 20 months prior to this presentation. Physical examination was remarkable for bradycardia. Electrocardiogram showed a junctional rhythm with heart rate of 35 bpm. Blood and urine cultures were negative. Despite successful urgent pacemaker placement, she had cardiac arrest the following day with unsuccessful cardiopulmonary resuscitation attempt...
May 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28184977/lateral-atrial-tunnel-fontan-operation-predisposes-to-the-junctional-rhythm
#18
Katarzyna Januszewska, Anna Schuh, Anja Lehner, Robert Dalla-Pozza, Edward Malec
The goal of the study was to compare the early postoperative course after fenestrated lateral atrial tunnel (LT) and non-fenestrated extracardiac conduit (EC) Fontan operation (FO) in a single center where both techniques were parallelly used. Between 2004 and 2012, 56(32.7%) children underwent LT and 113(66.1%) EC FO. The mean age was 3.7 ± 2.9 years and mean weight was 14.6 ± 7.3 kg. The most common malformation was hypoplastic left heart syndrome (50.9%). The general approach was to perform LT in children after hemi-Fontan operation and EC in patients after Glenn anastomosis...
April 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28087519/sympathetic-modulation-of-electrical-activation-in-normal-and-infarcted-myocardium-implications-for-arrhythmogenesis
#19
Olujimi A Ajijola, Robert L Lux, Anadjeet Khahera, OhJin Kwon, Eric Aliotta, Daniel B Ennis, Michael C Fishbein, Jeffrey L Ardell, Kalyanam Shivkumar
The influence of cardiac sympathetic innervation on electrical activation in normal and chronically infarcted ventricular myocardium is not understood. Yorkshire pigs with normal hearts (NL, n = 12) or anterior myocardial infarction (MI, n = 9) underwent high-resolution mapping of the anteroapical left ventricle at baseline and during left and right stellate ganglion stimulation (LSGS and RSGS, respectively). Conduction velocity (CV), activation times (ATs), and directionality of propagation were measured. Myocardial fiber orientation was determined using diffusion tensor imaging and histology...
March 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27997060/comparison-of-left-atrial-bipolar-voltage-and-scar-using-multielectrode-fast-automated-mapping-versus-point-by-point-contact-electroanatomic-mapping-in-patients-with-atrial-fibrillation-undergoing-repeat-ablation
#20
Jackson J Liang, Melissa A Elafros, Daniele Muser, Rajeev K Pathak, Pasquale Santangeli, Gregory E Supple, Robert D Schaller, David S Frankel, Sanjay Dixit
INTRODUCTION: Bipolar voltage criteria to delineate left atrial (LA) scar have been derived using point-by-point (PBP) contact electroanatomical mapping. It remains unclear how PBP-derived LA scar correlates with multielectrode fast automated mapping (ME-FAM) derived scar. We aimed to correlate scar and bipolar voltages from LA maps created using PBP versus ME-FAM. METHODS AND RESULTS: In consecutive patients undergoing repeat AF ablation, 2 separate LA maps were created using PBP and ME-FAM during sinus rhythm before ablation...
December 20, 2016: Journal of Cardiovascular Electrophysiology
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