keyword
MENU ▼
Read by QxMD icon Read
search

Junctional Rhythm

keyword
https://www.readbyqxmd.com/read/27904846/complete-congenital-heart-block-in-a-neonate-with-a-complex-congenital-heart-defect-in-africa
#1
Clovis Nkoke, Edvine Yonta Wawo, Liliane Kuate Mfeukeu, Larissa Makamte, Sandrine Dikosso Edie, Flore Esiene Balana
Congenital heart block (CHB) is rare disorder that has a higher mortality when associated with structural congenital heart defects. Very few cases have been reported in Sub-Saharan Africa (SSA). We present a case of complete CHB associated with a complex congenital heart defect in a neonate in Cameroon. A 1-month-old neonate in Cameroon was referred for the evaluation of bradycardia. The obstetrical ultrasound done during pregnancy revealed fetal bradycardia without further evaluation. Clinical examination showed well a developed neonate with bradycardia at 62 beats/minute, and mild cyanosis with oxygen saturation at 93% at room air...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27872501/synchronization-of-heterogeneous-oscillators-under-network-modifications-perturbation-and-optimization-of-the-synchrony-alignment-function
#2
Dane Taylor, Per Sebastian Skardal, Jie Sun
Synchronization is central to many complex systems in engineering physics (e.g., the power-grid, Josephson junction circuits, and electro-chemical oscillators) and biology (e.g., neuronal, circadian, and cardiac rhythms). Despite these widespread applications-for which proper functionality depends sensitively on the extent of synchronization-there remains a lack of understanding for how systems can best evolve and adapt to enhance or inhibit synchronization. We study how network modifications affect the synchronization properties of network-coupled dynamical systems that have heterogeneous node dynamics (e...
2016: SIAM Journal on Applied Mathematics
https://www.readbyqxmd.com/read/27826129/genotypic-and-phenotypic-predictors-of-complete-heart-block-and-recovery-of-conduction-following-surgical-repair-of-congenital-heart-disease
#3
Laura Murray, Andrew H Smith, English C Flack, Kim Crum, Jill Owen, Prince J Kannankeril
BACKGROUND: Complete heart block (CHB) is a major complication after congenital heart surgery. We hypothesized that genetic and clinical factors are associated with the development of postoperative CHB and recovery of atrioventricular (AV) conduction. OBJECTIVE: To identify predictors of CHB and recovery following congenital heart surgery. METHODS: Patients undergoing congenital heart surgery at our institution from September 2007 through June 2015 were prospectively enrolled in a parent study of postoperative arrhythmias...
November 5, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27810937/deficiency-of-cpeb2-confined-chat-expression-in-the-dorsal-motor-nucleus-of-vagus-causes-hyperactivated-parasympathetic-signaling-associated-bronchoconstriction
#4
Yen-Ting Lai, Chun-Kuei Su, Si-Tse Jiang, Ya-Jen Chang, Alan Chuan-Ying Lai, Yi-Shuian Huang
: Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is an RNA-binding protein and translational regulator. To understand the physiological function of CPEB2, we generated CPEB2 knockout (KO) mice and found that most died within 3 days after birth. CPEB2 is highly expressed in the brainstem, which controls vital functions like breathing. Whole-body plethysmography revealed that KO neonates had aberrant respiration with frequent apnea. Nevertheless, the morphology and function of respiratory rhythm generator and diaphragm neuromuscular junctions appeared normal...
November 3, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27799555/cardiac-electrical-defects-in-progeroid-mice-and-hutchinson-gilford-progeria-syndrome-patients-with-nuclear-lamina-alterations
#5
José Rivera-Torres, Conrado J Calvo, Anna Llach, Gabriela Guzmán-Martínez, Ricardo Caballero, Cristina González-Gómez, Luis J Jiménez-Borreguero, Juan A Guadix, Fernando G Osorio, Carlos López-Otín, Adela Herraiz-Martínez, Nuria Cabello, Alex Vallmitjana, Raul Benítez, Leslie B Gordon, José Jalife, José M Pérez-Pomares, Juan Tamargo, Eva Delpón, Leif Hove-Madsen, David Filgueiras-Rama, Vicente Andrés
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A alterations also occur in physiological aging. It remains unknown how defective prelamin A processing affects the cardiac rhythm. We show age-dependent cardiac repolarization abnormalities in HGPS patients that are also present in the Zmpste24(-/-) mouse model of HGPS. Challenge of Zmpste24(-/-) mice with the β-adrenergic agonist isoproterenol did not trigger ventricular arrhythmia but caused bradycardia-related premature ventricular complexes and slow-rate polymorphic ventricular rhythms during recovery...
October 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27789000/sinus-node-injury-during-adjunctive-superior-vena-cava-isolation-in-a-patient-with-triggered-atrial-fibrillation
#6
Andrés F Miranda-Arboleda, Jeffrey Munro, Komandoor Srivathsan
INTRODUCTION: Atrial fibrillation is the most common sustained heart arrhythmia. Premature beats arising from foci other than pulmonary veins have been related to its pathogenesis. METHODS AND RESULTS: A 64-year-old female underwent superior vena cava (SVC) isolation after triggers were identified originating from the SVC following pulmonary vein isolation; immediately after SVC isolation, she developed junctional rhythm with symptomatic hypotension requiring emergent management...
May 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/27766317/myocardial-architecture-and-patient-variability-in-clinical-patterns-of-atrial-fibrillation
#7
Kishan A Manani, Kim Christensen, Nicholas S Peters
Atrial fibrillation (AF) increases the risk of stroke by a factor of 4-5 and is the most common abnormal heart rhythm. The progression of AF with age, from short self-terminating episodes to persistence, varies between individuals and is poorly understood. An inability to understand and predict variation in AF progression has resulted in less patient-specific therapy. Likewise, it has been a challenge to relate the microstructural features of heart muscle tissue (myocardial architecture) with the emergent temporal clinical patterns of AF...
October 2016: Physical Review. E
https://www.readbyqxmd.com/read/27725543/infective-endocarditis-with-intermittent-atrioventricular-block-and-pseudoaneurysm-of-the-mitral-aortic-intervalvular-fibrosa-in-a-patient-with-severe-aortic-stenosis
#8
Hideyuki Hasebe, Akira Takanohashi, Kazuaki Shirota, Hajime Nakamura
Atrioventricular (AV) block and pseudoaneurysm of the mitral-aortic intervalvular fibrosa (P-MAIVF) are rare complications of infective endocarditis (IE). A 72-year-old man with severe aortic stenosis was hospitalized due to IE. After admission, intermittent AV block and P-MAIVF were noted. Interestingly, an accelerated junctional rhythm was observed during the process of AV block resolution. Elective surgery, which included patch closure of the fistula and replacement of the aortic valve, was successfully performed...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27693814/retinal-gap-junctions-are-involved-in-rhythmogenesis-of-neuronal-activity-at-remote-locations-study-on-infra-slow-oscillations-in-the-rat-olivary-pretectal-nucleus
#9
Patrycja Orlowska-Feuer, Jagoda S Jeczmien-Lazur, Hanna J Szkudlarek, Marian H Lewandowski
A subpopulation of olivary pretectal nucleus (OPN) neurons fire action potentials in a rhythmic manner with an eruption of activity occurring approximately every two minutes. These infra-slow oscillations depend critically on functional retinal input and are subject to modulation by light. Interestingly, the activity of photoreceptors is necessary for the emergence of the rhythm and while classic photoreceptors (rods and cones) are necessary in darkness and dim light, melanopsin photoreceptors are indispensable in bright light...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27555091/early-cardiac-electrographic-and-molecular-remodeling-in-a-model-of-status-epilepticus-and-acquired-epilepsy
#10
Amy L Brewster, Kyle Marzec, Alexandria Hairston, Marvin Ho, Anne E Anderson, Yi-Chen Lai
OBJECTIVES: A myriad of acute and chronic cardiac alterations are associated with status epilepticus (SE) including increased sympathetic tone, rhythm and ventricular repolarization disturbances. Despite these observations, the molecular processes underlying SE-associated myocardial remodeling remain to be identified. Here we determined early SE-associated myocardial electrical and molecular alterations using a model of SE and acquired epilepsy. METHODS: We performed electrocardiography (ECG) assessments in rats beginning at 2 weeks following kainate-induced SE, and calculated short-term variability (STV) of the corrected QT intervals (QTc) as a marker of ventricular stability...
November 2016: Epilepsia
https://www.readbyqxmd.com/read/27545043/mir-208b-upregulation-interferes-with-calcium-handling-in-hl-1-atrial-myocytes-implications-in-human-chronic-atrial-fibrillation
#11
Susana Cañón, Ricardo Caballero, Adela Herraiz-Martínez, Marta Pérez-Hernández, Begoña López, Felipe Atienza, José Jalife, Leif Hove-Madsen, Eva Delpón, Antonio Bernad
microRNAs (miR) have considerable potential as therapeutic tools in cardiac diseases. Alterations in atrial miR are involved in the development of atrial fibrillation (AF), but the molecular mechanism underlying their contribution to atrial remodeling in chronic atrial fibrillation (CAF) is only partially understood. Here we used miR array to analyze the miR profile of atrial biopsies from sinus rhythm (SR) and CAF patients. qRT-PCR identified a distinctive CAF-miR signature and described conserved miR-208b upregulation in human and ovine AF atrial tissue...
August 18, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27539163/catecholaminergic-polymorphic-ventricular-tachycardia-associated-with-sinus-node-dysfunction-and-junctional-rhythm-case-report-and-literature-review
#12
Natale Daniele Brunetti, Pier Luigi Pellegrino, Girolamo D'Arienzo, Rafel Sai, Luigi Ziccardi, Francesco Santoro, Antonio Gaglione, Matteo Di Biase
We report the case of a 38-year-old woman with history of syncope and polymorphic ventricular tachycardia; tachycardia was inducible at exercise stress test, not at electrophysiologic study. Phases of QT prolongation were found at ambulatory electrocardiogram monitoring. The woman came to our attention for periodic control of implantable loop recorder. Rest electrocardiogram at admission unexpectedly showed sinus bradycardia, junctional rhythm, and ventricular premature beats. Furthermore, loop recorder control revealed a short run of bidirectional tachycardia, not associated with syncope...
July 28, 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27530090/acute-sinus-node-dysfunction-after-atrial-ablation-incidence-risk-factors-and-management
#13
Ammar M Killu, Erin A Fender, Abhishek J Deshmukh, Thomas M Munger, Philip Araoz, Peter A Brady, Yong-Mei Cha, Douglas L Packer, Paul A Friedman, Samuel J Asirvatham, Peter A Noseworthy, Siva K Mulpuru
BACKGROUND: Many patients with atrial fibrillation (AF) or atrial flutter (Aflutter) have concomitant sinus node dysfunction (SND). Ablation may result in injury to the sinus node complex or its blood supply resulting in sinus arrest and need for temporary pacing. We sought to characterize patients who develop acute SND (ASND) during/immediately after AF/Aflutter ablation. METHODS: We performed a retrospective analysis of AF/Aflutter ablation patients between January 1, 2010 and February 28, 2015 to characterize those who required temporary pacemaker (TPM) implantation due to ASND (sinus arrest, sinus bradycardia <40 beats/min, or junctional rhythm with hemodynamic compromise) following atrial ablation...
October 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27510622/potassium-channels-in-the-cx43-gap-junction-perinexus-modulate-ephaptic-coupling-an-experimental-and-modeling-study
#14
Rengasayee Veeraraghavan, Joyce Lin, James P Keener, Robert Gourdie, Steven Poelzing
It was recently demonstrated that cardiac sodium channels (Nav1.5) localized at the perinexus, an intercalated disc (ID) nanodomain associated with gap junctions (GJ), may contribute to electrical coupling between cardiac myocytes via an ephaptic mechanism. Impairment of ephaptic coupling by acute interstitial edema (AIE)-induced swelling of the perinexus was associated with arrhythmogenic, anisotropic conduction slowing. Given that Kir2.1 has also recently been reported to localize at intercalated discs, we hypothesized that Kir2...
October 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27457110/junctional-bradycardia-is-a-potential-risk-factor-of-stroke
#15
Gwang Sil Kim, Jae-Sun Uhm, Tae-Hoon Kim, Hancheol Lee, Junbeom Park, Jin-Kyu Park, Boyoung Joung, Hui-Nam Pak, Moon-Hyoung Lee
BACKGROUND: This study aimed to determine the risk of thromboembolic events in patients with junctional bradycardia(JB). METHODS: We retrospectively reviewed electrocardiograms(ECGs) for 380,682 patients. Those with JB on an ECG at least twice over a ≥3-month interval were included for analysis. We additionally included 138 CHADS2 score-matched patients(age, 68.4 ± 15.7 years; male, 52.2%) in sinus rhythm as a control group. Between the JB patients(with or without retrograde P wave) and controls, we compared incidences of ischemic stroke and a composite of ischemic stroke, renal infarction, ischemic colitis, acute limb ischemia, and pulmonary embolism...
2016: BMC Neurology
https://www.readbyqxmd.com/read/27421240/is-electrical-coupling-involved-in-the-generation-of-posterior-hypothalamic-theta-rhythm
#16
Renata Bocian, Bartosz Caban, Paulina Kłos-Wojtczak, Jan Konopacki, Tomasz Kowalczyk
Data obtained in in vitro experiments and urethane anaesthetized animals have revealed that the mechanisms responsible for the generation of hippocampal cholinergic theta rhythm are specifically affected by the administration of broad spectrum gap junctions (GJs) blocker - carbenoxolone (CBX). The aim of this study was to examine the effect of GJs modulation on the production of posterior hypothalamic theta. Specifically, we were interested in evaluating whether CBX could attenuate the theta rhythm recorded from the supramammillary nucleus and posterior hypothalamic nuclei, in both in vitro and in vivo preparations...
September 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27414735/gap-junction-modifiers-regulate-electrical-activities-of-the-sinoatrial-node-and-pulmonary-vein-therapeutic-implications-in-atrial-arrhythmogenesis
#17
Chien-Jung Chang, Chen-Chuan Cheng, Yao-Chang Chen, Yu-Hsun Kao, Shih-Ann Chen, Yi-Jen Chen
BACKGROUND: Gap junction (GJ) dysfunctions predispose cardiac tissues to various arrhythmias. Sinoatrial node (SAN) and pulmonary veins (PVs) are closely related atrial dysrhythmia. This study evaluated whether GJ modifications modulate SAN and PVs electrical activities. METHODS: Conventional microelectrodes were used to record action potentials in isolated rabbit SAN, PVs, and connected PV-SAN tissue preparations before and after heptanol (GJ inhibitor) and PQ1 (GJ enhancer) administration with and without isoproterenol...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27396923/electrocardiographic-responses-to-deer-hunting-in-men-and-women
#18
Steven D Verba, Brock T Jensen, Jeffrey S Lynn
OBJECTIVE: Deer hunting includes various stimuli resulting in augmented sympathetic activity, increased heart rate (HR) response, and rhythm changes. Collectively, these superimposed stresses may increase an individual's risk for cardiovascular events. We undertook this study to evaluate HR and rhythm responses in multiple phases of deer hunting in men and women with and without cardiovascular disease (CVD). METHODS: Nineteen participants age 38.3 ± 13.8 years (mean ± SD) with body mass index 29...
September 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/27377173/co2-evoked-release-of-pge2-modulates-sighs-and-inspiration-as-demonstrated-in-brainstem-organotypic-culture
#19
David Forsberg, Zachi Horn, Evangelia Tserga, Erik Smedler, Gilad Silberberg, Yuri Shvarev, Kai Kaila, Per Uhlén, Eric Herlenius
Inflammation-induced release of prostaglandin E2 (PGE2) changes breathing patterns and the response to CO2 levels. This may have fatal consequences in newborn babies and result in sudden infant death. To elucidate the underlying mechanisms, we present a novel breathing brainstem organotypic culture that generates rhythmic neural network and motor activity for 3 weeks. We show that increased CO2 elicits a gap junction-dependent release of PGE2. This alters neural network activity in the preBötzinger rhythm-generating complex and in the chemosensitive brainstem respiratory regions, thereby increasing sigh frequency and the depth of inspiration...
2016: ELife
https://www.readbyqxmd.com/read/27371412/normal-sinus-rhythm-sinus-bradycardia-is-common-in-young-children-post-extracardiac-fontan
#20
William N Evans, Ruben J Acherman, Humberto Restrepo
We hypothesized that normal sinus rhythm-sinus bradycardia is common in young children following extracardiac Fontan. After excluding patients with sinus pauses, junctional rhythm, tachy-brady syndrome, frequent ectopics, or ectopic atrial rhythm, we found an ambulatory 24-h Holter monitor average heart rate of 78 ± 12 beats per minute (bpm) in 33 post-extracardiac Fontan children with a median age of 6 years (5-10). A 24-h average heart rate of 78 ± 12 bpm is statistically significantly lower than a 24-h average heart rate value of 90 ± 10 bpm derived from a similarly aged control population (p < 0...
October 2016: Pediatric Cardiology
keyword
keyword
107348
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"