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https://www.readbyqxmd.com/read/28599874/cisplatin-induced-arrhythmia-electrolyte-imbalance-or-disturbance-of-the-sa-node
#1
REVIEW
Rabbab Oun, Edward Rowan
Since its approval in 1979 cisplatin has become one of the most extensively used chemotherapeutics in the clinic and although cell resistance and toxicity hinder its efficacy it continues to be a gold standard regimen. Cisplatin's side effects primarily include nephrotoxicity, gastrointestinal toxicity, neurotoxicity and ototoxicity. Cardiotoxicity is generally not defined as a side effect of cisplatin. However, over the past decade there has been a surge in the amount of clinical cases reporting a vast array of cardio-toxic events occurring during or shortly after cisplatin infusion, these range from angina to cardiac ischemia and chronic heart failure...
June 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28560175/miliary-tuberculosis-with-cerebral-liver-prostate-and-retroesophageal-involvement
#2
Raquel Goncalves, Pedro Lopes, Patrícia Mendes, João Trêpa, João Rua, Rosa Sá, Isabel Ramos, J Saraiva da Cunha
Miliary tuberculosis results from the lymphohematogenous spread of Mycobacterium tuberculosis and it is a rare form of this disease. The most affected places are the lymph nodes, pleura, and osteoarticular system, but any organ can be involved. Currently the disease is still endemic in developing countries by its close association with poor living conditions and malnutrition. Other comorbidities, particularly infection by human immunodeficiency virus (HIV), diabetes mellitus, smoking and alcoholism are of great importance in the epidemiology of this disease...
2017: IDCases
https://www.readbyqxmd.com/read/28521476/differentiation-between-gastrointestinal-schwannomas-and-gastrointestinal-stromal-tumors-by-computed-tomography
#3
Ming-Yan He, Rong Zhang, Zhenpeng Peng, Yin Li, Ling Xu, Mengjie Jiang, Zi-Ping Li, Shi-Ting Feng
The aim of the present study was to identify computed tomography (CT) features to assist in differentiating gastrointestinal schwannomas from gastrointestinal stromal tumors (GISTs). CT images of gastrointestinal schwannomas (n=15) and GISTs (n=50) were analyzed. The absolute CT values of tumor/aorta during plain scan/arterial phase/venous phase were recorded as tumor plain scan (Tp)/aorta plain scan (Ap), tumor arterial phase (Ta)/aorta arterial phase (Aa) and tumor venous phase (Tv)/aorta venous phase (Av), respectively, and normalized CT values of the three phases were calculated as Sp=Tp/Ap, Sa=Ta/Aa and Sv=Tv/Av, respectively...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28515358/irf5-distinguishes-severe-asthma-in-humans-and-drives-th1-phenotype-and-airway-hyperreactivity-in-mice
#4
Timothy B Oriss, Mahesh Raundhal, Christina Morse, Rachael E Huff, Sudipta Das, Rachel Hannum, Marc C Gauthier, Kathryn L Scholl, Krishnendu Chakraborty, Seyed M Nouraie, Sally E Wenzel, Prabir Ray, Anuradha Ray
Severe asthma (SA) is a significant problem both clinically and economically, given its poor response to corticosteroids (CS). We recently reported a complex type 1-dominated (IFN-γ-dominated) immune response in more than 50% of severe asthmatics despite high-dose CS treatment. Also, IFN-γ was found to be critical for increased airway hyperreactivity (AHR) in our model of SA. The transcription factor IRF5 expressed in M1 macrophages can induce a Th1/Th17 response in cocultured human T cells. Here we show markedly higher expression of IRF5 in bronchoalveolar lavage (BAL) cells of severe asthmatics as compared with that in cells from milder asthmatics or healthy controls...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28508144/radical-lymph-node-dissection-along-the-proximal-splenic-artery-during-laparoscopic-gastrectomy-for-gastric-cancer-using-the-left-lateral-approach
#5
Shingo Kanaji, Satoshi Suzuki, Masashi Yamamoto, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Yasuo Sumi, Yoshihiro Kakeji
BACKGROUND: Recent technical improvements allow safe laparoscopic lymph node dissection (LND) in gastric cancer.1 (,) 2 In suprapancreatic LND, careful LND around the celiac artery (CA) is essential. From a patient's right side, deep LND is performed around the right side of the CA after dissecting around the common hepatic artery (CHA). For LND around the left side of the CA on the same operative axis as the right side, we developed a new procedure for LND along the proximal splenic artery (SA), performed from the patient's left side...
May 15, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28499865/implication-of-altered-autonomic-control-for-orthostatic-tolerance-in-sci
#6
REVIEW
Jill Maria Wecht, William A Bauman
Neural output from the sympathetic and parasympathetic branches of the autonomic nervous system (ANS) are integrated to appropriately control cardiovascular responses during routine activities of daily living including orthostatic positioning. Sympathetic control of the upper extremity vasculature and the heart arises from the thoracic cord between T1 and T5, whereas splanchnic bed and lower extremity vasculature receive sympathetic neural input from the lower cord between segments T5 and L2. Although the vasculature is not directly innervated by the parasympathetic nervous system, the SA node is innervated by post-ganglionic vagal nerve fibers via cranial nerve X...
May 3, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28495249/heart-rate-variability-to-monitor-performance-in-elite-athletes-criticalities-and-avoidable-pitfalls
#7
Daniela Lucini, Ilaria Marchetti, Antonio Spataro, Mara Malacarne, Manuela Benzi, Stefano Tamorri, Roberto Sala, Massimo Pagani
BACKGROUND: Spectral analysis of Heart Rate Variability (HRV) is a simple, non-invasive technique that is widely used in sport to assess sympatho-vagal regulation of the heart. Its employment is increasing partly due to the rising usage of wearable devices. However data acquisition using these devices may be suboptimal because they cannot discriminate between sinus and non-sinus beats and do not record any data regarding respiratory frequency. This information is mandatory for a correct clinical interpretation...
May 3, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28469934/systolic-blood-pressure-but-not-electrocardiogram-qrs-duration-is-associated-with-heart-rate-variability-hrv-a-cross-sectional-study-in-rural-australian-non-diabetics
#8
Yvonne Yin Leng Lee, Herbert F Jelinek, Craig S McLachlan
BACKGROUND: A positive correlation between ECG derived QRS duration and heart rate variability (HRV) parameters had previously been reported in young healthy adults. We note this study used a narrow QRS duration range, and did not adjust for systolic blood pressure. Our aims are to investigate associations between systolic blood pressure (SBP), QRS duration and HRV in a rural aging population. METHODS: A retrospective cross sectional population was obtained from the CSU Diabetes Screening Research Initiative data base where 200 participants had no diabetes or pre-diabetes...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28449114/neuro-symbolic-representation-learning-on-biological-knowledge-graphs
#9
Mona Alshahrani, Mohammed Asif Khan, Omar Maddouri, Akira R Kinjo, Núria Queralt-Rosinach, Robert Hoehndorf
Motivation: Biological data and knowledge bases increasingly rely on Semantic Web technologies and the use of knowledge graphs for data integration, retrieval and federated queries. In the past years, feature learning methods that are applicable to graph-structured data are becoming available, but have not yet widely been applied and evaluated on structured biological knowledge. Results: We develop a novel method for feature learning on biological knowledge graphs...
April 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28440794/se-sad-serial-femtosecond-crystallography-datasets-from-selenobiotinyl-streptavidin
#10
Chun Hong Yoon, Hasan DeMirci, Raymond G Sierra, E Han Dao, Radman Ahmadi, Fulya Aksit, Andrew L Aquila, Alexander Batyuk, Halilibrahim Ciftci, Serge Guillet, Matt J Hayes, Brandon Hayes, Thomas J Lane, Meng Liang, Ulf Lundström, Jason E Koglin, Paul Mgbam, Yashas Rao, Theodore Rendahl, Evan Rodriguez, Lindsey Zhang, Soichi Wakatsuki, Sébastien Boutet, James M Holton, Mark S Hunter
We provide a detailed description of selenobiotinyl-streptavidin (Se-B SA) co-crystal datasets recorded using the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS) for selenium single-wavelength anomalous diffraction (Se-SAD) structure determination. Se-B SA was chosen as the model system for its high affinity between biotin and streptavidin where the sulfur atom in the biotin molecule (C10H16N2O3S) is substituted with selenium. The dataset was collected at three different transmissions (100, 50, and 10%) using a serial sample chamber setup which allows for two sample chambers, a front chamber and a back chamber, to operate simultaneously...
April 25, 2017: Scientific Data
https://www.readbyqxmd.com/read/28350969/mechanisms-of-spontaneous-pacing-sinoatrial-nodal-cells-neonatal-cardiomyocytes-and-human-stem-cell-derived-cardiomyocytes
#11
Martin Morad, Xiao-Hua Zhang
The sinoatrial (SA) node is the primary site from which the mammalian heart is paced, but the mechanisms underlying the pacemaking still remain clouded. It is generally believed that the hyperpolarization-activated current If, encoded by hyperpolarization-activated cyclic nucleotide-gated (HCN) genes, contributes significantly to pacing, which in tandem with inward current generated by efflux of Ca(2+) via the Na(+)-Ca(2+) exchanger (NCX), resulting from the released Ca(2+), mediates the diastolic depolarization...
March 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28322470/anti-inflammatory-and-antioxidant-actions-of-copaiba-oil-are-related-to-liver-cell-modifications-in-arthritic-rats
#12
Cristiane V Castro Ghizoni, Ana P Arssufi Ames, Osmar A Lameira, Ciomar A Bersani Amado, Anacharis B Sá Nakanishi, Lívia Bracht, Maria R Marçal Natali, Rosane M Peralta, Adelar Bracht, Jurandir F Comar
The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15 g · kg(-1) , arthritic rats, and arthritic rats treated with copaiba oil (0...
March 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28240519/triple-negative-breast-cancer-at-the-university-hospital-mohammed-vi-%C3%A2-oujda
#13
o Al jarroudi, n Abda, Sa Brahmi, S Afqir
Introduction: The triple-negative breast cancer (TNBC), defined by the absence of receptors to oestrogen and progesterone and no histochemical expression of human epidermal receptor -2, is associated with a particularly aggressive behavior. The aim of our study was to determine the clinico-pathological, therapeutic and prognostic features associated with this type of breast cancer in Morocco. Methods: A cohort retrospective study, spread over 3 years, was conducted of 116 breast cancer patients, diagnosed between January 2009 and December 2011 at the Regional Center of Oncology...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28237016/the-situation-awareness-weighted-network-sawn-model-and-method-theory-and-application
#14
Alexander Kalloniatis, Irena Ali, Timothy Neville, Phuong La, Iain Macleod, Mathew Zuparic, Elizabeth Kohn
We introduce a novel model and associated data collection method to examine how a distributed organisation of military staff who feed a Common Operating Picture (COP) generates Situation Awareness (SA), a critical component in organisational performance. The proposed empirically derived Situation Awareness Weighted Network (SAWN) model draws on two scientific models of SA, by Endsley involving perception, comprehension and projection, and by Stanton et al. positing that SA exists across a social and semantic network of people and information objects in activities connected across a set of tasks...
May 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28229271/new-pet-ct-criterion-for-nodal-staging-in-non-small-cell-lung-cancer-measurement-of-the-ratio-of-section-area-of-standard-uptake-values-%C3%A2-2-5-lymph-node-section-area
#15
Yoshitaro Saito, Kazuhiro Imai, Koichi Ishiyama, Hajime Saito, Satoru Motoyama, Yusuke Sato, Hayato Konno, Satoshi Fujishima, Manabu Hashimoto, Yoshihiro Minamiya
BACKGROUND: The aim of the present study was to use surgical and histological results to develop a simple noninvasive technique for improving nodal staging using preoperative PET/CT in patients with resectable non-small cell lung cancer (NSCLC). METHODS: Preoperative PET/CT findings (163 patients) and pathological diagnoses after surgical resection were evaluated. Using PET/CT images, lymph node section area (SA), the maximum standardized uptake value (SUVmax), SA of SUV ≥2...
February 23, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28205094/knockdown-of-cardiac-kir3-1-gene-with-sirna-can-improve-bradycardia-in-an-experimental-sinus-bradycardia-rat-model
#16
Yang Li, Xiaodan Fu, Zhi Zhang, Bo Yu
The objective of this study was to explore whether the inhibition of potassium inwardly rectifying channel (Kir3.1) with short interfering RNA (siRNA) can improve bradycardia in an experimental sinus bradycardia rat model. 54 Sprague Dawley (SD) rats were randomly divided into three groups: experimental group, control group, and sham group. Sinus bradycardia model was established in SD rats through chemical ablation of sinoatrial (SA) node with 20% formaldehyde. Variations of Kir3.1 expression at mRNA and protein level were examined with qPCR and Western blotting...
May 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28196610/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-nodal-staging-in-non-small-cell-lung-carcinoma
#17
D Coutinho, A Oliveira, S Campainha, S Neves, M Guerra, J Miranda, A Furtado, D Tente, A Sanches, J Almeida, J Moura E Sá
INTRODUCTION: Lung cancer staging has recently evolved to include endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for nodal assessment. AIM: Evaluate the performance and safety of EBUS-TBNA as a key component of a staging algorithm for non-small cell lung carcinoma (NSCLC) and as a single investigation technique for diagnosis and staging of NSCLC. METHODS: Patients undergoing EBUS-TBNA for NSCLC staging at our institution between April 1, 2010 and December 31, 2014 were consecutively included with prospective data collection...
February 9, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28187776/mycobacterium-bovis-in-a-european-bison-bison-bonasus-raises-concerns-about-tuberculosis-in-brazilian-captive-wildlife-populations-a-case-report
#18
Cristina Kraemer Zimpel, Juliana Sperotto Brum, Antônio Francisco de Souza Filho, Alexander Welker Biondo, João Henrique Perotta, Cristina Corsi Dib, Marcelo Bonat, José Soares Ferreira Neto, Paulo Eduardo Brandão, Marcos Bryan Heinemann, Ana Marcia Sa Guimaraes
BACKGROUND: Tuberculosis caused by Mycobacterium bovis is an important worldwide zoonosis and has been reported to cause clinical disease in several animal species, including captive wildlife. This report describes a case of M. bovis infection in a European bison from a Brazilian zoo and compiles a number of literature reports that raise concern regarding tuberculosis among captive wildlife in Brazil. CASE PRESENTATION: A 13 year-old captive-born male bison (Bison bonasus) from a Brazilian zoo began presenting weight loss, diarrhea and respiratory symptoms, which inevitably led to his death...
February 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28187493/recurrence-of-hepatocellular-carcinoma-after-liver-transplantation-is-there-a-place-for-resection
#19
Elena Fernandez-Sevilla, Marc-Antoine Allard, Jasmijn Selten, Nicolas Golse, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, René Adam
Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is widely considered as a terminal condition. Therefore, the role of surgery is uncertain in this case. The purpose of this study was to identify the prognostic factors of survival after post-LT HCC recurrence and to evaluate the impact of surgery in this setting. All patients transplanted for HCC between 1991 and 2013 in a single institution and who further developed a post-LT recurrence were included in this study. Univariate and multivariate analyses were performed to identify factors affecting postrecurrence survival...
April 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28180046/risk-of-delayed-lymph-node-metastasis-in-clinically-n0-esthesioneuroblastoma
#20
Justin G Peacock, William S Harmsen, Michael J Link, Jamie J Van Gompel, Caterina Giannini, Kerry D Olsen, Yolanda I Garces, Michelle A Neben Wittich, Daniel J Ma, Sean S Park, Robert L Foote
Objective To determine both the rate of delayed cervical lymph node metastasis in patients with esthesioneuroblastoma (ENB) and a clinically N0 untreated neck and the effectiveness of salvage treatment. Design Retrospective review. Setting Tertiary academic medical center. Participants All patients from January 1, 1965, to December 31, 2010, who received definitive treatment for ENB. Main Outcome Measures The study involved 52 patients: 27 (52%) patients underwent surgery and adjuvant radiotherapy (SART) to the primary site only and 25 (48%) underwent surgery alone (SA) as treatment of the primary site, without elective neck dissection...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
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