Qian Yan, Xinxin Zhang, Yi Xie, Jing Yang, Chengxin Liu, Miaofen Zhang, Wenjiang Zheng, Xueying Lin, Hui-Ting Huang, Xiaohong Liu, Yong Jiang, Shao-Feng Zhan, Xiufang Huang
Airway epithelial transcriptome analysis of asthma patients with different severity was used to disentangle the immune infiltration mechanisms affecting asthma exacerbation, which may be advantageous to asthma treatment. Here we introduce various bioinformatics methods and develop two models: an OVA/CFA-induced neutrophil asthma mouse model and an LPS-induced human bronchial epithelial cell damage model. Our objective is to investigate the molecular mechanisms, potential targets, and therapeutic strategies associated with asthma severity...
February 14, 2024: Communications Biology