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Erythrocyte aggregation

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https://www.readbyqxmd.com/read/28536678/the-role-and-mechanism-of-erythrocyte-invasion-by-francisella-tularensis
#1
Deanna M Schmitt, Rebecca Barnes, Taylor Rogerson, Ashley Haught, Leanne K Mazzella, Matthew Ford, Tricia Gilson, James W-M Birch, Anders Sjöstedt, Douglas S Reed, Jonathan M Franks, Donna B Stolz, James Denvir, Jun Fan, Swanthana Rekulapally, Donald A Primerano, Joseph Horzempa
Francisella tularensis is an extremely virulent bacterium that can be transmitted naturally by blood sucking arthropods. During mammalian infection, F. tularensis infects numerous types of host cells, including erythrocytes. As erythrocytes do not undergo phagocytosis or endocytosis, it remains unknown how F. tularensis invades these cells. Furthermore, the consequence of inhabiting the intracellular space of red blood cells (RBCs) has not been determined. Here, we provide evidence indicating that residing within an erythrocyte enhances the ability of F...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28529915/hemolytic-uremic-syndrome-in-adults-a-case-report
#2
Fabiel Gerardo Pérez-Cruz, Patricia Villa-Díaz, María Consuelo Pintado-Delgado, María Loreto Fernández Rodríguez, Ana Blasco-Martínez, María Pérez-Fernández
Thrombotic microangiopathies (TMA) are microvascular occlusive disorders characterized by platelet aggregation and mechanical damage to erythrocytes, clinically characterized by microangiopatic haemolytic anemia, thrombocytopenia and organ injury. We are reporting a case of a woman patient with severe hemolytic uremic syndrome associated to infectious diarrhoea caused by Shiga toxin-producing pathogen, who were admitted to our intensive care unit. The patient described developed as organ injury, neurological failure and acute renal failure, with need of haemodialysis technique...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28514397/-vascular-permeability-and-intravascular-erythrocyte-aggregation-in-young-people-after-smoking-cessation
#3
B Z Sirotin, N V Korneeva
AIM: To study the parameters of microcirculation and permeability of the microvessels in young people who have ceased smoking. SUBJECTS AND METHODS: The study enrolled 35 healthy young adults (male to female ratio, 20:15; mean age, 21.71±0.46 years) who had stopped smoking 1 month to 10 years (mean 2.63±0.43 years) ago. The compared group consisted of 16 smokers (male to female ratio, 6:10; mean age, 21.62±0.72 years) and 29 non-smokers (male to female ratio, 8:21; mean age, 21...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28507436/design-of-polyaspartic-acid-peptide-poly-ethylene-glycol-poly-%C3%AE%C2%B5-caprolactone-nanoparticles-as-a-carrier-of-hydrophobic-drugs-targeting-cancer-metastasized-to-bone
#4
Jinsong Liu, Youyun Zeng, Shuai Shi, Lihua Xu, Hualin Zhang, Janak L Pathak, Yihuai Pan
Treatment of cancer metastasized to bone is still a challenge due to hydrophobicity, instability, and lack of target specificity of anticancer drugs. Poly (ethylene glycol)-poly (ε-caprolactone) polymer (PEG-PCL) is an effective, biodegradable, and biocompatible hydrophobic drug carrier, but lacks bone specificity. Polyaspartic acid with eight peptide sequences, that is, (Asp)8, has a strong affinity to bone surface. The aim of this study was to synthesize (Asp)8-PEG-PCL nanoparticles as a bone-specific carrier of hydrophobic drugs to treat cancer metastasized to bone...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28482621/effect-of-whole-body-cryotherapy-on-the-rheological-parameters-of-blood-in-older-women-with-spondyloarthrosis
#5
Aleksandra Kulis, Anna Misiorek, Jakub Marchewka, Jacek Głodzik, Aneta Teległów, Zbigniew Dąbrowski, Anna Marchewka
BACKGROUND: Cryotherapy is a physiotherapy method used to treat back pain in older persons. OBJECTIVE: This study aims to evaluate the changes in the rheological parameters of blood in older women with spondyloarthrosis, who underwent whole-body cryotherapy. METHODS: The experimental group comprised 69 older women with lumbar spondyloarthrosis, aged between 65 and 70 years. Due to the methodology of the procedure, the experimental group was randomly divided into three groups...
May 2, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28480839/effect-of-progesterone-and-synthetic-progestins-on-whole-blood-clot-formation-and-erythrocyte-structure
#6
Albe C Swanepoel, Odette Emmerson, Etheresia Pretorius
Combined oral contraceptive (COC) use is a risk factor for venous thrombosis (VT) and related to the specific type of progestin used. VT is accompanied by inflammation and pathophysiological clot formation, that includes aberrant erythrocytes and fibrin(ogen) interactions. In this paper, we aim to determine the influence of progesterone and different synthetic progestins found in COCs on the viscoelasticity of whole blood clots, as well as erythrocyte morphology and membrane ultrastructure, in an in vitro laboratory study...
May 8, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28458720/role-of-red-blood-cells-in-haemostasis-and-thrombosis
#7
Rustem I Litvinov, John W Weisel
In contrast to an obsolete notion that erythrocytes, or red blood cells (RBCs), play a passive and minor role in hemostasis and thrombosis, over the past decades there has been increasing evidence that RBCs have biologically and clinically important functions in blood clotting and its disorders. This review summarizes the main mechanisms that underlie the involvement of RBCs in hemostasis and thrombosis in vivo, such as rheological effects on blood viscosity and platelet margination, aggregation and deformability of RBCs; direct adhesion and indirect biochemical interactions with endothelial cells and platelets, etc...
February 2017: ISBT Science Series
https://www.readbyqxmd.com/read/28450113/a-co-releasing-molecule-prevents-annexin-a2-down-regulation-and-associated-disorders-in-lps-administered-rat-lung
#8
Kana Unuma, Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura
To investigate septic lung injuries and the possible relief from injury by carbon monoxide (CO), rats were intraperitoneally (i.p.) administered water or the water-soluble CO-releasing molecule CORM (30 mg/kg body weight), followed by the successive administration of PBS or lipopolysaccharide (LPS, 15 mg/kg body weight, 6 h). The results in four experimental groups (control, LPS, LPS + CORM, CORM, n = 3 or 4 in each groups) were examined. Histological examination revealed the intravascular aggregation of erythrocytes in the lungs of the LPS group, and serological analysis showed a significant increase in D-dimer in the LPS group...
April 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28429229/microcirculatory-bed-microcirculation-and-smoking-associated-endothelial-dysfunction-in-young-adults
#9
N V Korneeva, B Z Sirotin
Computer-assisted video biomicroscopy of bulbar conjunctiva was employed to examine the sequelae of endothelial dysfunction manifested by microcirculatory bed abnormalities and microcirculation disturbances. The signs of endothelial dysfunction provoked by tobacco smoking in young adults disappeared after cessation of smoking, which resulted in pronounced widening of arterioles and capillaries as well as moderation of intravascular erythrocyte aggregation.
April 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28420171/pannexin-and-connexin-mediated-intercellular-communication-in-platelet-function
#10
REVIEW
Filippo Molica, Florian B Stierlin, Pierre Fontana, Brenda R Kwak
The three major blood cell types, i.e., platelets, erythrocytes and leukocytes, are all produced in the bone marrow. While red blood cells are the most numerous and white cells are the largest, platelets are small fragments and account for a minor part of blood volume. However, platelets display a crucial function by preventing bleeding. Upon vessel wall injury, platelets adhere to exposed extracellular matrix, become activated, and form a platelet plug preventing hemorrhagic events. However, when platelet activation is exacerbated, as in rupture of an atherosclerotic plaque, the same mechanism may lead to acute thrombosis causing major ischemic events such as myocardial infarction or stroke...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28400185/purification-and-characterization-of-cc-lec-c-type-lactose-binding-lectin-a-platelet-aggregation-and-blood-clotting-inhibitor-from-cerastes-cerastes-venom
#11
Saoud Samah, Chérifi Fatah, Berjeaud Jean-Marc, Kellou-Taîri Safia, Laraba-Djebari Fatima
In this study, we reported for the first time the biochemical and structural characterization of Cc-Lec, a C-type lectin purified from Cerastes cerastes venom by affinity chromatography. This lectin was homogeneous by SDS-PAGE, and was shown to be a 34 271.59Da polypeptide by Electrospray mass spectrometry MS-ES-TOF. Its identified sequence of 160 amino acids corresponding to one subunit, revealed a high identity with other related proteins. Cc-Lec modeled 3D structure appeared as homodimer cross-linked by one disulfide bridge...
April 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28395141/an-efficient-microscale-technique-for-determining-the-erythrocyte-sedimentation-rate
#12
Akhil Chaturvedi, Sujith Kumar Nagaraj, Sai Siva Gorthi, Chandra Sekhar Seelamantula
The erythrocyte sedimentation rate (ESR) is a commonly used test to screen for inflammatory conditions such as infections, autoimmune diseases, and cancers. However, it is a bulk macroscale test that requires a relatively large blood sample and takes a long time to run. Moreover, it provides no information regarding cell sizes or interactions, which can be highly variable. To overcome these drawbacks, we developed a microfluidic microscopy-based protocol to dynamically track settling red blood cells (RBCs) to quantify velocity of cell settling, as a surrogate for the ESR...
April 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28375423/front-microrheology-of-the-non-newtonian-behaviour-of-blood-scaling-theory-of-erythrocyte-aggregation-by-aging
#13
C Trejo-Soto, E Costa-Miracle, I Rodriguez-Villarreal, J Cid, M Castro, T Alarcon, A Hernandez-Machado
We introduce a new framework to study the non-Newtonian behaviour of fluids at the microscale based on the analysis of front advancement. We apply this methodology to study the non-linear rheology of blood in microchannels. We carry out experiments in which the non-linear viscosity of blood samples is quantified at different haematocrits and ages. Under these conditions, blood exhibits a power-law dependence on the shear rate. In order to analyse our experimental data, we put forward a scaling theory which allows us to define an adhesion scaling number...
April 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28374705/-effects-of-chronic-tabacco-smoking-on-the-cerebral-blood-flow
#14
N V Zakharchuk, V A Nevzorova, V M Chertok, N S Sarafanova
AIM: To study an effect of chronic smoking on cerebral hemodynamics and cerebrovascular reactivity in different segments of the arterial system of the brain in men. MATERIAL AND METHODS: Male patients enrolled in the study were divided into two groups: controls (n=11) and smokers (n=24) with index 30.7 pack-year smoking history. Haemorheological parameters: viscosity of blood, aggregation of erythrocytes, hematocrit, fibrinogen were evaluated in both groups. Using carotid duplex ultrasound (MyLab 50 Esaote, Italy), intima-media thickness (IMT) of common carotid arteries (CCA) was measured...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28373047/sodium-alginate-and-gum-acacia-hydrogels-of-zinc-oxide-nanoparticles-reduce-hemolytic-and-oxidative-stress-inflicted-by-zinc-oxide-nanoparticles-on-mammalian-cells
#15
R Raguvaran, Anju Manuja, Balvinder K Manuja, T Riyesh, Sandeep Singh, M Kesavan, U Dimri
Zinc oxide nanoparticles are important nanomaterials currently under research due to their applicability in nanomedicine. Toxicity of ZnO NPs has been extensively studied and has been shown to affect various cell types and animal systems. In this study, we investigated hemolytic potential and oxidative stress inflicted by ZnO NPs and ZnO NPs-loaded-sodium alginate-gum acacia hydrogels on horse erythrocytes and African green monkey kidney (Vero) cells. Our study provides a better understanding of the hemolytic and oxidative effects of interaction of ZnO NPs and ZnO NPs released from polymeric hydrogels with the biological system...
March 31, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28323046/centaurium-erythraea-methanol-extract-protects-red-blood-cells-from-oxidative-damage-in-streptozotocin-induced-diabetic-rats
#16
Miloš Đorđević, Mirjana Mihailović, Jelena Arambašić Jovanović, Nevena Grdović, Aleksandra Uskoković, Anja Tolić, Marija Sinadinović, Jovana Rajić, Danijela Mišić, Branislav Šiler, Goran Poznanović, Melita Vidaković, Svetlana Dinić
ETHNOPHARMACOLOGICAL RELEVANCE: Centaurium erythraea Rafn (CE) is a traditional medicinal herb in Serbia with antidiabetic, digestive, antipyretic and antiflatulent effects. AIM OF THE STUDY: To investigate the potential protective effects of the methanol extract of the aerial parts of CE against glyco-oxidative stress in red blood cells (RBCs) in rats with experimentally induced diabetes. MATERIAL AND METHODS: Diabetes was induced in Wistar rats by intraperitoneal (i...
March 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28303012/tryptophan-end-tagging-for-promoted-lipopolysaccharide-interactions-and-anti-inflammatory-effects
#17
Shalini Singh, Aritreyee Datta, Artur Schmidtchen, Anirban Bhunia, Martin Malmsten
The objective of the present study is the investigation of possibilities for boosting peptide anti-inflammatory effects by tryptophan end-tagging, including identification of underlying mechanisms for this. In doing so, effects of tryptophan end-tagging of KYE21 (KYEITTIHNLFRKLTHRLFRR), a peptide derived from heparin co-factor II, on membrane and lipopolysaccharide (LPS) interactions were investigated by ellipsometry, NMR, fluorescence spectroscopy, and circular dichroism measurements. Through its N-terminal W stretch, WWWKYE21 displays higher membrane binding, liposome rupture, and bacterial killing than unmodified KYE21...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279845/design-synthesis-and-evaluation-of-novel-ferulic-acid-o-alkylamine-derivatives-as-potential-multifunctional-agents-for-the-treatment-of-alzheimer-s-disease
#18
Zhipei Sang, Wanli Pan, Keren Wang, Qinge Ma, Lintao Yu, Yan Yang, Ping Bai, Chaoliang Leng, Qian Xu, Xiaoqing Li, Zhenghuai Tan, Wenmin Liu
A series of novel ferulic acid-O-alkylamines derivatives were designed, synthesized, and evaluated as multitarget-directed ligands against Alzheimer's disease. In vitro studies displayed that all the synthesized target compounds showed impressive inhibitory activity against butyrylcholinesterase (BuChE), significant inhibition/disaggregation of self-induced β-amyloid (Aβ) aggregation and acted as potential antioxidants. Particularly, compound 7f, one of the most potent BuChE inhibitor (IC50 value of 0.021 μM for equine serum BuChE, 8...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28256646/magnetic-nanoparticles-for-drug-targeting-from-design-to-insights-into-systemic-toxicity-preclinical-evaluation-of-hematological-vascular-and-neurobehavioral-toxicology
#19
Mariela A Agotegaray, Adrián E Campelo, Roberto D Zysler, Fernanda Gumilar, Cristina Bras, Ariel Gandini, Alejandra Minetti, Virginia L Massheimer, Verónica L Lassalle
A simple two-step drug encapsulation method was developed to obtain biocompatible magnetic nanocarriers for the potential targeted treatment of diverse diseases. The nanodevice consists of a magnetite core coated with chitosan (Chit@MNPs) as a platform for diclofenac (Dic) loading as a model drug (Dic-Chit@MNPs). Mechanistic and experimental conditions related to drug incorporation and quantification are further addressed. This multi-disciplinary study aims to elucidate the toxicological impact of the MNPs at hematological, vascular, neurological and behavioral levels...
March 3, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28255347/enhanced-blood-suspensibility-and-laser-activated-tumor-specific-drug-release-of-theranostic-mesoporous-silica-nanoparticles-by-functionalizing-with-erythrocyte-membranes
#20
Jinghan Su, Huiping Sun, Qingshuo Meng, Pengcheng Zhang, Qi Yin, Yaping Li
Mesoporous silica nanoparticles (MSNs), with their large surface area and tunable pore sizes, have been widely applied for anticancer therapeutic cargos delivery with a high loading capacity. However, easy aggregation in saline buffers and limited blood circulation lifetime hinder their delivery efficiency and the anticancer efficacy. Here, new multifunctional MSNs-supported red-blood-cell (RBC)-mimetic theranostic nanoparticles with long blood circulation, deep-red light-activated tumor imaging and drug release were reported...
2017: Theranostics
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