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Erythrocyte aggregation

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https://www.readbyqxmd.com/read/29350685/re-orchestration-of-blood-flow-by-micro-circulations
#1
P A R Meyer
Haemoglobin Video Imaging (HVI) demonstrates conjunctival and episcleral blood flow in man with the resolution of a single erythrocyte. A new method for establishing vessel hierarchy in micro-circulations is described, which recognises either delivery or drainage vessels and references vessel order to the capillary. These tools have been used to characterise blood flow.Anterior ciliary arteries show pulsatile variation in diameter. The episcleral arterial circle that they supply has functional apices with pulsatile flow reversal...
January 19, 2018: Eye
https://www.readbyqxmd.com/read/29332028/possible-erythrocyte-contributions-to-and-exacerbation-of-the-post-thrombolytic-no-reflow-phenomenon
#2
Shang-Jen Yu, James P Buerck, Edgar A O'Rear, Thomas L Whitsett
BACKGROUND: Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation. OBJECTIVE: To assess possible red cell contributions to post thrombolytic no-reflow phenomenon. METHODS: Blood clots were formed by recalcifying 1 ml of citrated fresh human venous blood and then lysed by adding 1,000 units of streptokinase (SK) at several intervals within 1 hour...
January 11, 2018: Biorheology
https://www.readbyqxmd.com/read/29318859/-xingnao-kaiqiao-acupuncture-acupuncture-technique-for-restoring-consciousness-combined-with-hyperbaric-oxygen-in-patients-with-hypoxic-ischemic-encephalopathy-clinical-observation-and-its-influence-on-blood-rheology
#3
Sheng-Yu Zhang, Shao-Bing Liu, Hong-Wu Xie, Yi-Min Chen, Kang-Lin Liao, Yong Xiang, Dun Pan
OBJECTIVE: To observe the effect of "Xingnao Kaiqiao" acupuncture(acupuncture technique for restoring consciousness) combined with hyperbaric oxygen in patients with hypoxic ischemic encephalopathy and assess its influence on blood rheology. METHODS: Forty patients with hypoxic ischemic encephalopathy were randomly divided into treatment group and control group with 20 cases in each group. The treatment group received "Xingnao Kaiqiao" acupuncture combined with hyperbaric oxygen, and the control group received hyperbaric oxygen only...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29295657/comparing-coagulation-activity-of-selaginella-tamariscina-before-and-after-stir-frying-process-and-determining-the-possible-active-constituents-based-on-compositional-variation
#4
Qian Zhang, Ya-Li Wang, Die Gao, Liang Cai, Yi-Yao Yang, Yuan-Jia Hu, Feng-Qing Yang, Hua Chen, Zhi-Ning Xia
CONTEXT: Selaginella tamariscina (P. Beauv.) Spring (Selaginellaceae) (ST) has been widely used in China as a medicine for improving blood circulation. However, its processed product, S. tamariscina carbonisatus (STC), possesses opposite haemostatic activity. OBJECTIVE: To comprehensively evaluate the activity of ST and STC on physiological coagulation system of rats, and seek potential active substances accounting for the activity transformation of ST during processing...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29215846/-possibilities-of-correction-rheological-blood-svoytv-at-chipped-and-cut-wounds-of-the-breast
#5
V V Masljakov, O A Suhanova, V G Barsukov, K G Kurkin, S A Suhanov
The purpose: research objective: to study influence of electromagnetic oscillations of millimetric range on rheological properties of blood at patients with chipped and cut wounds of a breast for the purpose of their correction. Methods. For the solution of a research objective we have carried out studying of changes of rheological properties of blood at the 22nd patient with the getting chipped and cut wounds of a breast without internal injury during the next postoperative period. All patient has executed primary surgical processing and drainage of a pleural cavity...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29195992/phenotypic-characterization-of-cronobacter-spp-strains-isolated-from-foods-and-clinical-specimens-in-brazil
#6
Natália Scudeller Umeda, Ivano de Filippis, Stephen James Forsythe, Marcelo Luiz Lima Brandão
Several Cronobacter species are opportunistic pathogens that cause infections in humans. This study evaluated the phenotypic characteristics of 57 Cronobacter strains (C. sakazakii n=41, C. malonaticus n=10, C. dublinensis n=4, and C. muytjensii n=2) isolated from food (n=54) and clinical specimens (n=3) in Brazil. These strains included sequence types (ST): ST395-ST398, ST402, ST413 and ST433-ST439, isolated from food samples, and three C. malonaticus clinical strains previous isolated from an outbreak which were ST394 (n=1) and ST440 (n=2)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29171826/tertiary-care-centre-adherence-to-unified-guidelines-for-management-of-periprosthetic-joint-infections-a-gap-analysis
#7
Mitchel D Armstrong, Alberto V Carli, Hesham Abdelbary, Stephane Poitras, Peter Lapner, Paule E Beaule
BACKGROUND: The success rate of surgical treatment for periprosthetic joint infection (PJI) remains inconsistent in the literature. Variability in PJI clinical guidelines and surgeon adherence to guidelines could affect treatment success. The objectives of this study were to appraise current recommendations for PJI management and develop a unified clinical standard of care, to perform a gap analysis of PJI cases in a tertiary institution to determine the rate of guideline adherence, and to determine if adherence to unified PJI guidelines affected 2-year treatment outcomes...
December 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29166708/-effects-of-astragalus-polysaccharide-on-cardiac-dysfunction-in-rabbits-with-severe-scald-injury
#8
L Zhong, J H Zhan, J H Luo, X Cheng
Objective: To investigate the effects of astragalus polysaccharide (AP) on cardiac dysfunction in rabbits with severe scald injury. Methods: Sixty-four New Zealand white rabbits were divided into pure scald group and AP group according to the random number table, with 32 rabbits in each group. Rabbits in the two groups were all inflicted with 30% total body surface area full-thickness scald on the back. Immediately after injury, rabbits in two groups were intraperitoneally injected with lactated Ringer's solution once for antishock...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29145008/morphological-changes-in-erythrocytes-of-people-with-type-2-diabetes-mellitus-evaluated-with-atomic-force-microscopy-a-brief-review
#9
REVIEW
Alejandra Loyola-Leyva, Juan Pablo Loyola-Rodríguez, Marco Atzori, Francisco Javier González
Prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Cardiovascular diseases are one of the main causes of death among people with T2DM. Morphological changes in erythrocytes have been associated with higher risk of cardiovascular diseases. Atomic force microscopy (AFM) is a new technique that allows non-invasive imaging of cells and the evaluation of changes in mechanical properties. AIM: To evaluate by AFM the erythrocytes morphological changes of people with T2DM METHODS: Search was conducted from in PubMed, ScienceDirect, Scielo, and Lilacs...
November 10, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29139273/-comparative-study-on-promoting-blood-effects-of-danshen-honghua-herb-pair-with-different-preparations-based-on-chemometrics-and-multi-attribute-comprehensive-index-methods
#10
Cheng Qu, Yu-Ping Tang, Xu-Qin Shi, Gui-Sheng Zhou, Er-Xin Shang, Li-Li Shang, Jian-Ming Guo, Pei Liu, Jing Zhao, Bu-Chang Zhao, Jin-Ao Duan
To evaluate the promoting blood circulation and removing blood stasis effects of Danshen-Honghua(DH) herb pair with different preparations (alcohol, 50% alcohol and water) on blood rheology and coagulation functions in acute blood stasis rats, and optimize the best preparation method of DH based on principal component analysis(PCA), hierarchical cluster heatmap analysis and multi-attribute comprehensive index methods. Ice water bath and subcutaneous injection of adrenaline were both used to establish the acute blood stasis rat model...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29133350/extracellular-histones-induce-erythrocyte-fragility-and-anemia
#11
Farzaneh Kordbacheh, Connor H O'Meara, Lucy A Coupland, Patrick M Lelliott, Christopher R Parish
Extracellular histones have been shown to play an important pathogenic role in many diseases, primarily through their cytotoxicity towards nucleated cells and their ability to promote platelet activation with resultant thrombosis and thrombocytopenia. In contrast, little is known about the effect of extracellular histones on erythrocyte function. We demonstrate here that histones promote erythrocyte aggregation, sedimentation and, using a novel in vitro shear stress model, induce erythrocyte fragility and lysis in a concentration dependent manner...
November 13, 2017: Blood
https://www.readbyqxmd.com/read/29089816/impaired-hemorheology-in-exacerbations-of-copd
#12
Erhan Ugurlu, Emine Kilic-Toprak, Ilknur Can, Ozgen Kilic-Erkek, Goksel Altinisik, Melek Bor-Kucukatay
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. MATERIALS AND METHODS: The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29077251/in-vitro-and-in-vivo-antithrombotic-and-cytotoxicity-effects-of-ferulic-acid
#13
Jun-Hui Choi, Jong-Kook Park, Ki-Man Kim, Hyo-Jeong Lee, Seung Kim
We discovered recently in vitro and in vivo antithrombotic and cytotoxicity effects of ferulic acid. The cytotoxicity assays showed that ferulic acid (∼300 μg/mL) did not cause any significant toxicity on three cell lines, platelets, leukocytes, and erythrocytes. In vitro assays showed inhibitory effects of ferulic acid on thrombin (THR)- or collagen/epinephrine-stimulated platelet activation by inhibiting platelet aggregation, and decreasing clot retraction activity. The in vitro effect of ferulic acid on THR-stimulated platelet activation was proved by the decrease in the secretion of serotonin from the platelets...
October 27, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29068226/sequence-control-as-a-powerful-tool-for-improving-the-selectivity-of-antimicrobial-polymers
#14
Agnes Kuroki, Parveen Sangwan, Yue Qu, Raoul Peltier, Carlos Sanchez-Cano, John Moat, Christopher G Dowson, Elizabeth G L Williams, Katherine E S Locock, Matthias Hartlieb, Sebastien Perrier
Antimicrobial polymers appear as a promising alternative to tackle the current development of bacterial resistance against conventional antibiotics as they rely on bacterial membrane disruption. This study investigates the effect of segmentation of hydrophobic and cationic functionalities on antimicrobial polymers over their selectivity between bacteria and mammalian cells. Using RAFT technology, statistical, diblock and highly segmented multiblock copolymers were synthesized in a controlled manner. Polymers were analysed by HPLC and the segmentation was found to have a significant influence on their overall hydrophobicity...
October 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29052682/probing-blood-cell-mechanics-of-hematologic-processes-at-the-single-micron-level
#15
Jordan C Ciciliano, Reza Abbaspour, Julia Woodall, Caroline Wu, Muhannad S Bakir, Wilbur A Lam
Blood cells circulate in a dynamic fluidic environment, and during hematologic processes such as hemostasis, thrombosis, and inflammation, blood cells interact biophysically with a myriad of vascular matrices-blood clots and the subendothelial matrix. While it is known that adherent cells physiologically respond to the mechanical properties of their underlying matrices, how blood cells interact with their mechanical microenvironment of vascular matrices remains poorly understood. To that end, we developed microfluidic systems that achieve high fidelity, high resolution, single-micron PDMS features that mimic the physical geometries of vascular matrices...
November 7, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29050398/delineating-sptan1-associated-phenotypes-from-isolated-epilepsy-to-encephalopathy-with-progressive-brain-atrophy
#16
Steffen Syrbe, Frederike L Harms, Elena Parrini, Martino Montomoli, Ulrike Mütze, Katherine L Helbig, Tilman Polster, Beate Albrecht, Ulrich Bernbeck, Ellen van Binsbergen, Saskia Biskup, Lydie Burglen, Jonas Denecke, Bénédicte Heron, Henrike O Heyne, Georg F Hoffmann, Frauke Hornemann, Takeshi Matsushige, Ryuki Matsuura, Mitsuhiro Kato, G Christoph Korenke, Alma Kuechler, Constanze Lämmer, Andreas Merkenschlager, Cyril Mignot, Susanne Ruf, Mitsuko Nakashima, Hirotomo Saitsu, Hannah Stamberger, Tiziana Pisano, Jun Tohyama, Sarah Weckhuysen, Wendy Werckx, Julia Wickert, Francesco Mari, Nienke E Verbeek, Rikke S Møller, Bobby Koeleman, Naomichi Matsumoto, William B Dobyns, Domenica Battaglia, Johannes R Lemke, Kerstin Kutsche, Renzo Guerrini
De novo in-frame deletions and duplications in the SPTAN1 gene, encoding the non-erythrocyte αII spectrin, have been associated with severe West syndrome with hypomyelination and pontocerebellar atrophy. We aimed at comprehensively delineating the phenotypic spectrum associated with SPTAN1 mutations. Using different molecular genetic techniques, we identified 20 patients with a pathogenic or likely pathogenic SPTAN1 variant and reviewed their clinical, genetic and imaging data. SPTAN1 de novo alterations included seven unique missense variants and nine in-frame deletions/duplications of which 12 were novel...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29042768/systemic-toxicity-induced-by-aggregated-layered-double-hydroxide-nanoparticles
#17
Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao
Layered double hydroxide (LDH) nanoparticles are emerging as one of the promising nanomaterials for biomedical applications, but their systemic toxicity in vivo has received little attention. In the present study, the effects of inorganic nanoparticle aggregation on their systemic toxicity were examined. Remarkably, aggregation was observed after the mixing of naked LDH nanoparticles with saline or erythrocytes. Significant accumulation of the naked LDH nanoparticles in the lungs of mice was detected 1 h after intravenous administration, and the survival rate of mice was 0% after 6 repeated injections...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29036796/intestinal-ischemia-reperfusion-leads-to-early-systemic-micro-rheological-and-multiorgan-microcirculatory-alterations-in-the-rat
#18
Anita Mester, Zsuzsanna Magyar, Viktoria Sogor, Bence Tanczos, Yoav Stark, Konstantin Cherniavsky, Laszlo Bidiga, Katalin Peto, Norbert Nemeth
BACKGROUND: Intestinal ischemia-reperfusion (I/R) is a potentially life-threatening situation and its pathomechanism is not fully understood yet. OBJECTIVE: To investigate the early micro-rheological, microcirculatory and morphological consequences of intestinal I/R in a rat model. METHODS: CD rats were anesthetized and subjected to Control (n = 7) or I/R (n = 7) groups. Left femoral artery cannulation and median laparotomy were performed...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29026299/glycogen-gold-nanohybrid-escalates-the-potency-of-silymarin
#19
Raghuram Kandimalla, Suvakanta Dash, Ashim Chandra Bhowal, Sanjeeb Kalita, Narayan Chandra Talukdar, Sarathi Kundu, Jibon Kotoky
In this study, a glycogen-gold nanohybrid was fabricated to enhance the potency of a promising hepatoprotective agent silymarin (Sly) by improving its solubility and gut permeation. By utilizing a facile green chemistry approach, biogenic gold nanoparticles were synthesized from Annona reticulata leaf phytoconstituents in combination with Sly (SGNPs). Further, the SGNPs were aggregated in glycogen biopolymer to yield the therapeutic nanohybrids (GSGNPs). Transmission electron microscopy, UV-Vis spectroscopy, X-ray diffraction, and Fourier transform infrared spectroscopy analysis confirmed the successful formation and conjugation of both SGNPs and GSGNPs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28988373/lithium-treatment-aggregates-the-adverse-effects-on-erythrocytes-subjected-to-arsenic-exposure
#20
Priti Bhardwaj, Kinnri Jain, Devinder Kumar Dhawan
The present study was designed to investigate the effects of lithium treatment on red blood cells which were given arsenic exposure. Long-term lithium therapy is being extensively used for the treatment of bipolar disorders. Arsenic is a group I carcinogen and a major toxic pollutant in drinking water that affects millions of people worldwide. Male SD rats were segregated into four groups, viz. normal control, lithium treated, arsenic treated, and lithium + arsenic treated. Lithium was supplemented as lithium carbonate at a dose level of 1...
October 7, 2017: Biological Trace Element Research
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